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3. High Positive End-expiratory Pressure (PEEP) with Recruitment Maneuvers versus Low PEEP during General Anesthesia for Surgery: A Bayesian Individual Patient Data Meta-analysis of Three Randomized Clinical Trials

Author

Mazzinari, Guido, Zampieri, Fernando G., Ball, Lorenzo, Campos, Niklas S., Bluth, Thomas, Hemmes, Sabrine N. T., Ferrando, Carlos, Librero, Julian, Soro, Marina, Pelosi, Paolo, Gama de Abreu, Marcelo, Schultz, Marcus J., Serpa Neto, Ary, Campos, Niklas S., Bluth, Thomas, Hemmes, Sabrine N.T., Ferrando, Carlos, Pelosi, Paolo, de Abreu, Marcelo Gama, Schultz, Marcus J., Neto, Ary Serpa, Campos, Niklas S., Bluth, Thomas, Hemmes, Sabrine N.T., Librero, Julian, Pozo, Natividad, Ferrando, Carlos, Ball, Lorenzo, Mazzinari, Guido, Pelosi, Paolo, de Abreu, Marcelo Gama, Schultz, Marcus J., Neto, Ary Serpa, Hemmes, Sabrine N.T., Gama de Abreu, Marcelo, Severgnini, Paolo, Hollmann, Markus W., Binnekade, Jan M., Wrigge, Hermann, Canet, Jaume, Hiesmayr, Michael, Schmid, Werner, Tschernko, Edda, Jaber, Samir, Hedenstierna, Göran, Putensen, Christian, Pelosi, Paolo, Schultz, Marcus J., Marti, Agnes, Bacuzzi, Alessandro, Brodhun, Alexander, Molin, Alexandre, Merten, Alfred, Parera, Ana, Brunelli, Andrea, Cortegiani, Andrea, Güldner, Andreas, Reske, Andreas W., Gratarola, Angelo, Giarratano, Antonino, Bastin, Bea, Heyse, Bjorn, Mazul-Sunko, Branka, Amantea, Bruno, Barberis, Bruno, Putensen, Christian, Uhlig, Christopher, Minguez Marín, Conrado, Celentano, Cristian, La Bella, Daniela, D’Antini, David, Velghe, David, Sulemanji, Demet, De Robertis, Edoardo, Hartmann, Eric, Montalto, Francesca, Tropea, Francesco, Mills, Gary H., Cinnella, Gilda, Rocca, Giorgio Della, Caggianelli, Girolamo, Pellerano, Giulia, Mollica, Giuseppina, Bugedo, Guillermo, Wrigge, Hermann, Mulier, Jan-Paul, Vandenbrande, Jeroen, Geib, Johann, Yaqub, Jonathan, Florez, Jorge, Mayoral, Juan F., Sprung, Juraj, Van Limmen, Jurgen, Bos, Lieuwe D.J., de Baerdemaeker, Luc, Jamaer, Luc, Spagnolo, Luigi, Strys, Lydia, Granell Gil, Manuel, de Abreu, Marcelo Gama, Vidal Melo, Marcos F., Schultz, Marcus J., Unzueta, Maria Carmen, Moral, Maria Victoria, Ferner, Marion, Hollmann, Markus W., Weiss, Martin, Vanoni, Massimo, Schaefer, Maximilian S., Prieto, Mercè, Grio, Michele, Severgnini, Paolo, Spieth, Peter Markus, Simon, Philipp, Bodger, Phoebe, Sierra, Pilar, Laufenberg-Feldmann, Rita, Rusca, Roberta, Proietti, Rodolfo, Hemmes, Sabrine N.T., Raineri, Santi Maurizio, Caroleo, Santo, Sabaté, Sergi, De Hert, Stefan, Pezzato, Stefano, Treschan, Tanja A., Goranovic, Tatjana, Koch, Thea, Bluth, Thomas, Kiss, Thomas, Perilli, Valter, Cegarra, Virginia, Schmid, Werner, Ferrando, Carlos, Belda, Javier, Soro, Marina, Canet, Jaume, Unzueta, Carmen, Suarez-Sipmann, Fernando, Librero, Julián, Llombart, Alicia, Rovira, Lucas, Granell, Manuel, Aldecoa, César, Diaz-Cambronero, Oscar, Balust, Jaume, Garutti, Ignacio, Gonzalez, Rafael, Gallego, Lucia, del Valle, Santiago Garcia, Redondo, Javier, Pestaña, David, Rodríguez, Aurelio, García, Javier, de la Matta, Manuel, Ibáñez, Maite, Barrios, Francisco, Hernández, Samuel, Torres, Vicente, Peiró, Salvador, Pozo, Natividad, Villena, Abigail, Carramiñana, Albert, Gallego-Casilda, Alberto, Duca, Alejandro, Alcón, Amalia, Miñana, Amanda, Asensio, Ana, Colás, Ana, Isabel Galve, Ana, Izquierdo, Ana, Jurado, Ana, María Pérez, Ana, Mugarra, Ana, Parera, Ana, Brunelli, Andrea, Gutierrez, Andrea, De Miguel, Ángeles, Lozano, Angels, Katime, Antonio, Romero, Antonio, Garrigues, Beatriz, Ayas, Begoña, Arocas, Blanca, Delgado, Carlos, Fernández, Carmen, Romero, Carolina, Gallego, Clara, Garcés, Cristina, Lisbona, Cristina, Parrilla, Cristina, López-Herrera, Daniel, González, Domingo, Llamazares, Eduardo, Del Rio, Elena, Lozano, Elena, Pastor, Ernesto, Chamorro, Estefanía, Gracia, Estefanía, Sánchez, Ester, Romero, Esther, Díez, Fernando, Serralta, Ferran, Daviu, Francisco, Sandín, Francisco, Aguilar, Gerardo, Tusman, Gerardo, Azparren, Gonzalo, Martínez-Pallí, Graciela, Mazzinari, Guido, Benítez, Inmaculada, Hernandéz, Inmaculada, India, Inmaculada, León, Irene, Fuentes, Isabel, Ruiz, Isabel, Puig, Jaume, Ignacio Román, Javie, Acosta, Jesús, Rico, Jesús, Olmedo, Jonathan, Carbonell, Jose A., Alonso, Jose M., María Pérez, Jose, Miguel Marcos, Jose, Navarro, Jose, Valdivia, Jose, Carrizo, Juan, Piqueras, Laura, Soriano, Laura, Vaquero, Laura, Miguel, Lisset, Muñoz, Lorena, Valencia, Lucia, Olmedilla, Luis, Etulain, Ma Justina, Tisner, Manuel, Barrio, María, Dolores Alonso, María, García, María, Hernández, María J., José Alberola, María, Parra, María, Pilar Argente, María, Vila, María, De Fez, Mario, Agilaga, Marta, Gine, Marta, Ayuso, Mercedes, García, Mercedes, Bejarano, Natalia, Peña, Natalia, Ojeda, Nazario, Martínez, Nilda, García, Nuria, Padrón, Oto, García, Pablo, Valls, Paola, Cruz, Patricia, Piñeiro, Patricia, Charco, Pedro, Anaya, Rafael, López, Ramiro, Rodríguez, Rayco, Martínez, Rocío, Pujol, Roger, Dosdá, Rosa, Lardies, Rosa, Díaz, Ruben, Villazala, Rubén, Zapatero, Sara, Cabrera, Sergio, Sánchez, Sergio, Martin, Silvia, Diaz, Suzana, Franco, Tania, Moreno, Tania, Socorro, Tania, Gilabert, Vicente, Balandrón, Victor, Moral, Victoria, Cegarra, Virgina, Varón, Viviana, Bluth, Thomas, Serpa Neto, Ary, Bobek, Ilona, Canet, Jaume, Cinnella, Gilda, de Baerdemaeker, Luc, Gregoretti, Cesare, Hedenstierna, Göran, Hemmes, Sabrine N.T., Hiesmayr, Michael, Hollmann, Markus W., Jaber, Samir, Laffey, John, Licker, Marc-Joseph, Markstaller, Klaus, Matot, Idit, Mills, Gary H., Mulier, Jan Paul, Putensen, Christian, Rossaint, Rolf, Schmitt, Jochen, Senturk, Mert, Severgnini, Paolo, Sprung, Juraj, Vidal Melo, Marcos F., Wrigge, Hermann, Schultz, Marcus J., Pelosi, Paolo, de Abreu, Marcelo Gama, Abelha, Fernando, Abitağaoğlu, Sühayla, Achilles, Marc, Adebesin, Afeez, Adriaensens, Ine, Ahene, Charles, Akbar, Fatima, Al Harbi, Mohammed, Al Khoury al Kallab, Rita, Albanel, Xavier, Aldenkortt, Florence, Alfouzan, Rawan Abdullah Saleh, Alruqaie, Reef, Altermatt, Fernando, Araujo, Bruno Luís de Castro, Arbesú, Genaro, Artsi, Hanna, Aurilio, Caterina, Ayanoglu, Omer Hilmi, Bacuzzi, Alessandro, Baig, Harris, Baird, Yolanda, Balonov, Konstantin, Balust, Jaume, Banks, Samantha, Bao, Xiaodong, Baumgartner, Mélanie, Belda Tortosa, Isabel, Bergamaschi, Alice, Bergmann, Lars, Bigatello, Luca, Biosca Pérez, Elena, Birr, Katja, Bluth, Thomas, Bojaxhi, Elird, Bonenti, Chiara, Bonney, Iwona, Bos, Elke M.E., Bowman, Sara, Braz, Leandro Gobbo, Brugnoni, Elisa, Brull, Sorin J., Brunetti, Iole, Bruni, Andrea, Buenvenida, Shonie L., Busch, Cornelius Johannes, Camerini, Giovanni, Canet, Jaume, Capatti, Beatrice, Carmona, Javiera, Carungcong, Jaime, Carvalho, Marta, Cattan, Anat, Cavaleiro, Carla, Chiumello, Davide, Ciardo, Stefano, Coburn, Mark, Colella, Umberto, Contreras, Victor, Corman Dincer, Pelin, Cotter, Elizabeth, Crovetto, Marcia, Darrah, William, Davies, Simon, de Baerdemaeker, Luc, De Hert, Stefan, Del Cojo Peces, Enrique, Delphin, Ellise, Diaper, John, do Nascimento, Paulo, Jr., Donatiello, Valerio, Dong, Jing, Dourado, Maria do Socorro, Dullenkopf, Alexander, Ebner, Felix, Elgendy, Hamed, Ellenberger, Christoph, Erdoğan Ari, Dilek, Ermert, Thomas, Farah, Fadi, Fernandez-Bustamante, Ana, Ferreira, Cristina, Fiore, Marco, Fonte, Ana, Fortià Palahí, Christina, Galimberti, Andrea, Gama de Abreu, Marcelo, Garofano, Najia, Giaccari, Luca Gregorio, Gilsanz, Fernando, Girrbach, Felix, Gobbi, Luca, Godfried, Marc Bernard, Goettel, Nicolai, Goldstein, Peter A., Goren, Or, Gorlin, Andrew, Granell Gil, Manuel, Gratarola, Angelo, Graterol, Juan, Guyon, Pierre, Haire, Kevin, Harou, Philippe, Helf, Antonia, Hemmes, Sabrine N.T., Hempel, Gunther, Hernández Cádiz, María José, Heyse, Björn, Hollmann, Markus W., Huercio, Ivan, Ilievska, Jasmina, Jakus, Lien, Jeganath, Vijay, Jelting, Yvonne, Jung, Minoa, Kabon, Barbara, Kacha, Aalok, Karaman Ilić, Maja, Karuppiah, Arunthevaraja, Kavas, Ayse Duygu, Keli Barcelos, Gleicy, Kellogg, Todd A., Kemper, Johann, Kerbrat, Romain, Khodr, Suraya, Kienbaum, Peter, Kir, Bunyamin, Kiss, Thomas, Kivrak, Selin, Klarić, Vlasta, Koch, Thea, Köksal, Ceren, Kowark, Ana, Kranke, Peter, Kuvaki, Bahar, Kuzmanovska, Biljana, Laffey, John, Lange, Mirko, Lemos, Marília Freitas de, Licker, Marc-Joseph, López-Baamonde, Manuel, López-Hernández, Antonio, Lopez-Martinez, Mercedes, Luise, Stéphane, MacGregor, Mark, Machado, Humberto S., Magalhães, Danielle, Maillard, Julien, Malerbi, Patrizia, Manimekalai, Natesan, Margarson, Michael, Markstaller, Klaus, Martin, Archer K, Martin, David P., Martin, Yvette N., Martínez-Ocon, Julia, Martin-Loeches, Ignacio, Maseda, Emilio, Matot, Idit, McAuliffe, Niamh, McKenzie, Travis J., Medina, Paulina, Meersch, Melanie, Menzen, Angelika, Mertens, Els, Meurer, Bernd, Meyer-Treschan, Tanja, Miao, Changhong, Micalizzi, Camilla, Milić, Morena, Módolo, Norma Sueli Pinheiro, Moine, Pierre, Mölders, Patrick, Montero-Feijoo, Ana, Moret, Enrique, Muller, Markus K, Murphy, Zoe, Nalwaya, Pramod, Filip, Naumovski, Navalesi, Paolo, Navarro e Lima, Lais Helena, Nesek Adam, Višnja, Neumann, Claudia, Newell, Christopher, Nisnevitch, Zoulfira, Nizamuddin, Junaid, Novazzi, Cecilia, Nunes, Catarina S, O’Connor, Michael, Oprea, Günther, Orhan Sungur, Mukadder, Özbilgin, Şule, Pace, Maria Caterina, Pacheco, Marcos, Packianathaswamy, Balaji, Palma Gonzalez, Estefania, Papaspyros, Fotios, Paredes, Sebastián, Passavanti, Maria Beatrice, Pedemonte, Juan Cristobal, Pelosi, Paolo, Peremin, Sanja, Philipsenburg, Christoph, Pinho, Daniela, Pinho, Silvia, Posthuma, Linda M., Pota, Vincenzo, Preckel, Benedikt, Priani, Paolo, Putensen, Christian, Rached, Mohamed Aymen, Radoeshki, Aleksandar, Ragazzi, Riccardo, Rajamanickam, Tamilselvan, Rajamohan, Arthi, Ramakrishna, Harish, Rangarajan, Desikan, Reiterer, Christian, Renew, J. Ross, Reynaud, Thomas, Rhys, Rhidian, Rivas, Eva, Robitzky, Luisa, Rossaint, Rolf, Rubulotta, Francesca, Sabbatini, Giovanni, Samuels, Jon D, Sanahuja, Josep Martí, Sansone, Pasquale, Santos, Alice, Sayedalahl, Mohamed, Schaefer, Maximilian S., Scharffenberg, Martin, Schiffer, Eduardo, Schliewe, Nadja, Schorer, Raoul, Schultz, Marcus J., Schumann, Roman, Selmo, Gabriele, Sendra, Mar, Senturk, Mert, Severgnini, Paolo, Shaw, Kate, Shosholcheva, Mirjana, Sibai, Abdulrazak, Simon, Philipp, Simonassi, Francesca, Sinno, Claudia, Sivrikoz, Nukhet, Skandalou, Vasiliki, Smith, Neil, Soares, Maria, Socorro Artiles, Tania, Sousa Castro, Diogo, Sousa, Miguel, Spadaro, Savino, Sprung, Juraj, Stamatakis, Emmanouil, Steiner, Luzius A., Stevenazzi, Andrea, Suarez-de-la-Rica, Alejandro, Suppan, Mélanie, Teichmann, Robert, Tena Guerrero, José Maria, Thiel, Bram, Tolós, Raquel, Tucci, Michelle, Turnbull, Zachary A., Turudić, Žana, Unterberg, Matthias, Van Limmen, Jurgen, Van Nieuwenhove, Yves, Van Waesberghe, Julia, Vidal Melo, Marcos Francisco, Vitković, Bibiana, Vivona, Luigi, Vizcaychipi, Marcela, Volta, Carlo Alberto, Weber, Anne, Weingarten, Toby N., Wittenstein, Jakob, Wrigge, Hermann, Wyffels, Piet, Yagüe, Julio, Yates, David, Yavru, Ayşen, Zac, Lilach, and Zhong, Jing

Published
2025
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4. Home Blood Pressure Self-monitoring plus Self-titration of Antihypertensive Medication for Poorly Controlled Hypertension in Primary Care: the ADAMPA Randomized Clinical Trial

Author

Martínez-Ibáñez, Patricia, Marco-Moreno, Irene, Peiró, Salvador, Martínez-Ibáñez, Lucia, Barreira-Franch, Ignacio, Bellot-Pujalte, Laura, Avelino-Hidalgo, Eugenia, Escrig-Veses, Marina, Bóveda-García, María, Calleja-del-Ser, Mercedes, Ferrero-Gregori, Andreu, Iftimi, Adina A., Hurtado, Isabel, García-Sempere, Aníbal, Rodríguez-Bernal, Clara L, Giménez-Loreiro, Margarita, Sanfélix-Gimeno, Gabriel, and Sanfélix-Genovés, José

Published
2023
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6. The effectiveness of mRNA vaccines to prevent SARS-CoV-2 infection and hospitalisation for COVID-19 according to the time elapsed since their administration in health professionals in the Valencian Autonomous Community (Spain)

Author

Chico-Sánchez, Pablo, Gras-Valentí, Paula, Algado-Sellés, Natividad, Jiménez-Sepúlveda, Natali, Vanaclocha, Hermelinda, Peiró, Salvador, Burgos, Javier S., Berenguer, Ana, Navarro, David, and Sánchez-Payá, José

Published
2022
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7. Intraoperative positive end-expiratory pressure and postoperative pulmonary complications: a patient-level meta-analysis of three randomised clinical trials

Author

Hemmes, Sabrine NT., Gama de Abreu, Marcelo, Severgnini, Paolo, Hollmann, Markus W., Binnekade, Jan M., Wrigge, Hermann, Canet, Jaume, Hiesmayr, Michael, Schmid, Werner, Tschernko, Edda, Jaber, Samir, Hedenstierna, Göran, Putensen, Christian, Pelosi, Paolo, Schultz, Marcus J., Marti, Agnes, Bacuzzi, Alessandro, Brodhun, Alexander, Molin, Alexandre, Merten, Alfred, Parera, Ana, Brunelli, Andrea, Cortegiani, Andrea, Güldner, Andreas, Reske, Andreas W., Gratarola, Angelo, Giarratano, Antonino, Bastin, Bea, Heyse, Bjorn, Mazul-Sunko, Branka, Amantea, Bruno, Barberis, Bruno, Uhlig, Christopher, Marín, Conrado Minguez, Celentano, Cristian, La Bella, Daniela, D’Antini, David, Velghe, David, Sulemanji, Demet, De Robertis, Edoardo, Hartmann, Eric, Montalto, Francesca, Tropea, Francesco, Mills, Gary H., Cinnella, Gilda, Della Rocca, Giorgio, Caggianelli, Girolamo, Pellerano, Giulia, Mollica, Giuseppina, Bugedo, Guillermo, Mulier, Jan-Paul, Vandenbrande, Jeroen, Geib, Johann, Yaqub, Jonathan, Florez, Jorge, Mayoral, Juan F., Sprung, Juraj, Van Limmen, Jurgen, Bos, Lieuwe DJ., de Baerdemaeker, Luc, Jamaer, Luc, Spagnolo, Luigi, Strys, Lydia, Gil, Manuel Granell, Vidal Melo, Marcos F., Unzueta, Maria Carmen, Moral, Maria Victoria, Ferner, Marion, Weiss, Martin, Vanoni, Massimo, Schaefer, Maximilian S., Prieto, Mercè, Grio, Michele, Spieth, Peter Markus, Simon, Philipp, Bodger, Phoebe, Sierra, Pilar, Laufenberg-Feldmann, Rita, Rusca, Roberta, Proietti, Rodolfo, Raineri, Santi Maurizio, Caroleo, Santo, Sabaté, Sergi, De Hert, Stefan, Pezzato, Stefano, Treschan, Tanja A., Goranovic, Tatjana, Koch, Thea, Bluth, Thomas, Kiss, Thomas, Perilli, Valter, Cegarra, Virginia, Ferrando, Carlos, Belda, Javier, Soro, Marina, Unzueta, Carmen, Suarez-Sipmann, Fernando, Librero, Julián, Llombart, Alicia, Rovira, Lucas, Granell, Manuel, Aldecoa, César, Diaz-Cambronero, Oscar, Balust, Jaume, Garutti, Ignacio, Gonzalez, Rafael, Gallego, Lucia, Garcia del Valle, Santiago, Redondo, Javier, Pestaña, David, Rodríguez, Aurelio, García, Javier, Matta, Manuel de la, Ibáñez, Maite, Barrios, Francisco, Hernández, Samuel, Torres, Vicente, Peiró, Salvador, Pozo, Natividad, Villena, Abigail, Carramiñana, Albert, Gallego-Casilda, Alberto, Duca, Alejandro, Alcón, Amalia, Miñana, Amanda, Asensio, Ana, Colás, Ana, Galve, Ana Isabel, Izquierdo, Ana, Jurado, Ana, Pérez, Ana María, Mugarra, Ana, Gutierrez, Andrea, De Miguel, Ángeles, Lozano, Angels, Katime, Antonio, Romero, Antonio, Garrigues, Beatriz, Ayas, Begoña, Arocas, Blanca, Delgado, Carlos, Fernández, Carmen, Romero, Carolina, Gallego, Clara, Garcés, Cristina, Lisbona, Cristina, Parrilla, Cristina, López-Herrera, Daniel, González, Domingo, Llamazares, Eduardo, Del Rio, Elena, Lozano, Elena, Pastor, Ernesto, Chamorro, Estefanía, Gracia, Estefanía, Sánchez, Ester, Romero, Esther, Díez, Fernando, Serralta, Ferran, Daviu, Francisco, Sandín, Francisco, Aguilar, Gerardo, Tusman, Gerardo, Azparren, Gonzalo, Martínez-Pallí, Graciela, Mazzinari, Guido, Benítez, Inmaculada, Hernandéz, Inmaculada, India, Inmaculada, León, Irene, Fuentes, Isabel, Ruiz, Isabel, Puig, Jaume, Román, Javie Ignacio, Acosta, Jesús, Rico-Feijoo, Jesús, Olmedo, Jonathan, Carbonell, Jose A., Alonso, Jose M., Pérez, Jose María, Marcos, Jose Miguel, Navarro, Jose, Valdivia, Jose, Carrizo, Juan, Piqueras, Laura, Soriano, Laura, Vaquero, Laura, Miguel, Lisset, Muñoz, Lorena, Valencia, Lucia, Olmedilla, Luis, Etulain, Mᵃ Justina, Tisner, Manuel, Barrio, María, Alonso, María Dolores, García, María, Hernández, María J., Alberola, María José, Parra, María, Argente, María Pilar, Vila, María, De Fez, Mario, Agilaga, Marta, Gine, Marta, Ayuso, Mercedes, García, Mercedes, Bejarano, Natalia, Peña, Natalia, Ojeda, Nazario, Martínez, Nilda, García, Nuria, Padrón, Oto, García, Pablo, Valls, Paola, Cruz, Patricia, Piñeiro, Patricia, Charco, Pedro, Anaya, Rafael, López, Ramiro, Rodríguez, Rayco, Martínez, Rocío, Pujol, Roger, Dosdá, Rosa, Lardies, Rosa, Díaz, Ruben, Villazala, Rubén, Zapatero, Sara, Cabrera, Sergio, Sánchez, Sergio, Martin, Silvia, Diaz, Suzana, Franco, Tania, Moreno, Tania, Socorro, Tania, Gilabert, Vicente, Balandrón, Victor, Moral, Victoria, Cegarra, Virgina, Varón, Viviana, Abelha, Fernando, Abitağaoğlu, Sühayla, Achilles, Marc, Adebesin, Afeez, Adriaensens, Ine, Ahene, Charles, Akbar, Fatima, Al Harbi, Mohammed, Al Khoury al Kallab, Rita, Albanel, Xavier, Aldenkortt, Florence, Saleh Alfouzan, Rawan Abdullah, Alruqaie, Reef, Altermatt, Fernando, Luís de Castro Araujo, Bruno, Arbesú, Genaro, Artsi, Hanna, Aurilio, Caterina, Ayanoglu, Omer Hilmi, Baig, Harris, Baird, Yolanda, Balonov, Konstantin, Banks, Samantha, Bao, Xiaodong, Baumgartner, Mélanie, Tortosa, Isabel Belda, Bergamaschi, Alice, Bergmann, Lars, Bigatello, Luca, Pérez, Elena Biosca, Birr, Katja, Bojaxhi, Elird, Bonenti, Chiara, Bonney, Iwona, Bos, Elke M.E., Bowman, Sara, Braz, Leandro Gobbo, Brugnoni, Elisa, Brull, Sorin J., Brunetti, Iole, Bruni, Andrea, Buenvenida, Shonie L., Busch, Cornelius Johannes, Camerini, Giovanni, Capatti, Beatrice, Carmona, Javiera, Carungcong, Jaime, Carvalho, Marta, Cattan, Anat, Cavaleiro, Carla, Chiumello, Davide, Ciardo, Stefano, Coburn, Mark, Colella, Umberto, Contreras, Victor, Dincer, Pelin Corman, Cotter, Elizabeth, Crovetto, Marcia, Darrah, William, Davies, Simon, Del Cojo Peces, Enrique, Delphin, Ellise, Diaper, John, Junior, Paulo do Nascimento, Donatiello, Valerio, Dong, Jing, Dourado, Maria do Socorro, Dullenkopf, Alexander, Ebner, Felix, Elgendy, Hamed, Ellenberger, Christoph, Arı, Dilek Erdoğan, Ermert, Thomas, Farah, Fadi, Fernandez-Bustamante, Ana, Ferreira, Cristina, Fiore, Marco, Fonte, Ana, Palahí, Christina Fortià, Galimberti, Andrea, Garofano, Najia, Giaccari, Luca Gregorio, Gilsanz, Fernando, Girrbach, Felix, Gobbi, Luca, Godfried, Marc Bernard, Goettel, Nicolai, Goldstein, Peter A., Goren, Or, Gorlin, Andrew, Graterol, Juan, Guyon, Pierre, Haire, Kevin, Harou, Philippe, Helf, Antonia, Hemmes, Sabrine N.T., Hempel, Gunther, Hernández Cádiz, María José, Heyse, Björn, Huercio, Ivan, Ilievska, Jasmina, Jakus, Lien, Jeganath, Vijay, Jelting, Yvonne, Jung, Minoa, Kabon, Barbara, Kacha, Aalok, Ilić, Maja Karaman, Karuppiah, Arunthevaraja, Kavas, Ayse Duygu, Barcelos, Gleicy Keli, Kellogg, Todd A., Kemper, Johann, Kerbrat, Romain, Khodr, Suraya, Kienbaum, Peter, Kir, Bunyamin, Kivrak, Selin, Klarić, Vlasta, Köksal, Ceren, Kowark, Ana, Kranke, Peter, Kuvaki, Bahar, Kuzmanovska, Biljana, Laffey, John, Lange, Mirko, Freitas de Lemos, Marília, Licker, Marc-Joseph, López-Baamonde, Manuel, López-Hernández, Antonio, Lopez-Martinez, Mercedes, Luise, Stéphane, MacGregor, Mark, Magalhães, Danielle, Maillard, Julien, Malerbi, Patrizia, Manimekalai, Natesan, Margarson, Michael, Markstaller, Klaus, Martin, Archer K., Martin, David P., Martin, Yvette N., Martínez-Ocon, Julia, Martin-Loeches, Ignacio, Maseda, Emilio, Matot, Idit, McAuliffe, Niamh, McKenzie, Travis J., Medina, Paulina, Meersch, Melanie, Menzen, Angelika, Mertens, Els, Meurer, Bernd, Meyer-Treschan, Tanja, Miao, Changhong, Micalizzi, Camilla, Milić, Morena, Pinheiro Módolo, Norma Sueli, Moine, Pierre, Mölders, Patrick, Montero-Feijoo, Ana, Moret, Enrique, Muller, Markus K., Murphy, Zoe, Nalwaya, Pramod, Naumovski, Filip, Navalesi, Paolo, Navarro e Lima, Lais Helena, Adam, Višnja Nesek, Neumann, Claudia, Newell, Christopher, Nisnevitch, Zoulfira, Nizamuddin, Junaid, Novazzi, Cecilia, O'Connor, Michael, Oprea, Günther, Sungur, Mukadder Orhan, Özbilgin, Şule, Pace, Maria Caterina, Pacheco, Marcos, Packianathaswamy, Balaji, Gonzalez, Estefania Palma, Papaspyros, Fotios, Paredes, Sebastián, Passavanti, Maria Beatrice, Pedemonte, Juan Cristobal, Peremin, Sanja, Philipsenburg, Christoph, Pinho, Daniela, Pinho, Silvia, Posthuma, Linda M., Pota, Vincenzo, Preckel, Benedikt, Priani, Paolo, Rached, Mohamed Aymen, Radoeshki, Aleksandar, Ragazzi, Riccardo, Rajamanickam, Tamilselvan, Rajamohan, Arthi, Ramakrishna, Harish, Rangarajan, Desikan, Reiterer, Christian, Renew, J. Ross, Reynaud, Thomas, Rhys, Rhidian, Rivas, Eva, Robitzky, Luisa, Rossaint, Rolf, Rubulotta, Francesca, Machado, Humberto S., Nunes, Catarina S., Sabbatini, Giovanni, Samuels, Jon D., Sanahuja, Josep Martí, Sansone, Pasquale, Santos, Alice, Sayedalahl, Mohamed, Scharffenberg, Martin, Schiffer, Eduardo, Schliewe, Nadja, Schorer, Raoul, Schumann, Roman, Selmo, Gabriele, Sendra, Mar, Senturk, Mert, Shaw, Kate, Shosholcheva, Mirjana, Sibai, Abdulrazak, Simonassi, Francesca, Sinno, Claudia, Sivrikoz, Nukhet, Skandalou, Vasiliki, Smith, Neil, Soares, Maria, Artiles, Tania Socorro, Castro, Diogo Sousa, Sousa, Miguel, Spadaro, Savino, Stamatakis, Emmanouil, Steiner, Luzius A., Stevenazzi, Andrea, Suarez-de-la-Rica, Alejandro, Suppan, Mélanie, Teichmann, Robert, Tena Guerrero, José Maria, Thiel, Bram, Tolós, Raquel, Altun, Gulbin Tore, Tucci, Michelle, Turnbull, Zachary A., Turudić, Žana, Unterberg, Matthias, Van Nieuwenhove, Yves, Van Waesberghe, Julia, Vidal Melo, Marcos Francisco, Vitković, Bibiana, Vivona, Luigi, Vizcaychipi, Marcela, Volta, Carlo Alberto, Weber, Anne, Weingarten, Toby N., Wittenstein, Jakob, Wyffels, Piet, Yagüe, Julio, Yates, David, Yavru, Ayşen, Zac, Lilach, Zhong, Jing, Campos, Niklas S., Librero, Julian, Ball, Lorenzo, and Serpa Neto, A.

Published
2022
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8. Immunological response against SARS-CoV-2 following full-dose administration of Comirnaty® COVID-19 vaccine in nursing home residents

Author

Burgos, J.S., Meneu de Guillerna, R., Vanaclocha Luna, H., Burks, D.J., Cervantes, A., Comas, I., Díez-Domingo, J., Peiro, S., González-Candelas, F., Ferrer Albiach, C., Hernández-Aguado, I., Oliver Ramírez, N., Sánchez-Payá, J., Vento Torres, M., Zapater Latorre, E., Navarro, D., Albert, Eliseo, Burgos, Javier S., Peiró, Salvador, Salas, Dolores, Vanaclocha, Hermelinda, Giménez, Estela, Limón, Ramón, Alcaraz, María Jesús, Sánchez-Payá, José, Díez-Domingo, Javier, and Navarro, David

Published
2022
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11. Effects of oxygen on post-surgical infections during an individualised perioperative open-lung ventilatory strategy: a randomised controlled trial

Author

Acosta, Jesús, Alberola, María J., Alcón, Amalia, Almajano, Rosa, Álvarez, Carlos, Anaya, Rafael, Aragón, Cristian, Argilaga, Marta, Arocas, Blanca, Ayas, Begoña, Balandrón, Victor, Bárcena, Elizabeth, Bejarano, Natalia, Belmonte, Luis, Berges, Vanesa, Guillén Bermejo, Maria, Cabadas, Rafael, Cabrera, Sergio, Callejas, Raquel, Carbonell, Jose, Carrizo, Juan, Castillo, Jesús, Charco, Pedro, Colás, Ana, Colomina, Lorena, Cotter, Laura, Cruz, Patricia, Cuervo, Javier, Del Castillo, Gema, Del Río, Elena, Delgado, Juan, Dexeus, Carlos, Díaz, Rubén, Dinu, Mandalina, Duca, Alejandro, Duque, Paula, Echarri, Gemma, Fabra, Patricia, Fernández, Carmen, Florea, Raluca, Forcada, Pilar, Fuentes, Isabel, Garcés, Cristina, Del Valle, Santiago G., García, Beatriz, García, Esther, García, María, García, Mercedes, Garrigues, Beatriz, Garutti, Ignacio, Gil, Fernando, González, Domingo, Gracia, Alejandro, Gracia, Estefanía, Granell, Manuel, Guerra, Yessica, Gutierrez, Andrea, Hernando, Julia, Herrero, Miriam, Ibáñez, Maite, Imaz, Inés, Izquierdo, Blanca, Jurado, Ana, Lafuente, Noelia, Lascorz, Laura, León, Irene, López, Antonio, López-Herrera, Daniel, Lozano, Angels, Marcos, José M., Martínez, Graciela, Martínez, Sara, Mata, Esperanza, Matoses, Salomé, Mendez, Rosa, Merino, María, Millaruelo, Andrés, Molina, Carlos R., Monleon, Berta, Montenegro, Omar M., Mugarra, Ana, Muñoz, Jose L., Oliver-Forniés, Pablo, Ortega, Manuel, Palencia, María A., Parera, Ana, Pastor, Ernesto, del Mar Pérez, Maria, Pérez, Sara, Pestaña, David, Piñol, Santiago, Puig, Jaume, Pujol, Roger, Quesada, Natividad, Ramón, Ana, Rego, Consuelo, Reviriego, Laura, Rodríguez, Rayco, Romero, Blanca, Romero, Esther, Roselló, Marta, Rovira, Lucas, Ruiz, Lola, Sancho, Laura, Sandín, Francisco, Serralta, Ferran, Tres, Eva, Valls, Paola, Vaquero, Laura, Varela, Marina, Vega, Victor, Viguera, Laura, Villazala, Rubén, Villena, Abigail, Visiedo, Sara, Ferrando, Carlos, Aldecoa, César, Unzueta, Carmen, Belda, F. Javier, Librero, Julián, Tusman, Gerardo, Suárez-Sipmann, Fernando, Peiró, Salvador, Pozo, Natividad, Brunelli, Andrea, Gallego, Clara, Rodríguez, Aurelio, García, Jose Ignacio, Díaz-Cambronero, Oscar, Balust, Jaume, Redondo, Francisco J., de la Matta, Manuel, Gallego-Ligorit, Lucía, Hernández, Javier, Martínez, Pascual, Pérez, Ana, Leal, Sonsoles, Alday, Enrique, Monedero, Pablo, González, Rafael, Mazzirani, Guido, Aguilar, Gerardo, López-Baamonde, Manuel, Felipe, Mar, Torrente, Jara, Valencia, Lucia, Varón, Viviana, Sánchez, Sergio, Rodríguez, Benigno, Martín, Ana, India, Inmaculada, Azparren, Gonzalo, Molina, Rodrigo, Villar, Jesús, and Soro, Marina

Published
2020
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12. Effectiveness of mRNA booster doses in preventing infections and hospitalizations due to SARS-CoV-2 and its dominant variant over time in Valencian healthcare workers, Spain

Author

Universidad de Alicante. Departamento de Enfermería Comunitaria, Medicina Preventiva y Salud Pública e Historia de la Ciencia, Jiménez-Sepúlveda, Natali Juliet, Gras-Valentí, Paula, Chico-Sánchez, Pablo, Castro-García, José Miguel, Ronda-Pérez, Elena, Vanaclocha Luna, Hermelinda, Peiró, Salvador, Burgos, Javier S., Berenguer, Ana, Navarro, David, Sánchez-Payá, José, Universidad de Alicante. Departamento de Enfermería Comunitaria, Medicina Preventiva y Salud Pública e Historia de la Ciencia, Jiménez-Sepúlveda, Natali Juliet, Gras-Valentí, Paula, Chico-Sánchez, Pablo, Castro-García, José Miguel, Ronda-Pérez, Elena, Vanaclocha Luna, Hermelinda, Peiró, Salvador, Burgos, Javier S., Berenguer, Ana, Navarro, David, and Sánchez-Payá, José

Abstract

Objective: This study aimed to evaluate the effectiveness of SARS-CoV-2 mRNA vaccines in preventing infection and hospitalization among healthcare workers (HCWs) in the Valencian Community (Spain), considering vaccination timing, dose number, and predominant variant. Methods: A test-negative case-control design estimated vaccine effectiveness against symptomatic disease and hospitalization due to SARS-CoV-2. HCWs who underwent PCR or antigen testing for SARS-CoV-2 from January 2021 to March 2022 were included. Cases had a positive diagnostic test, while controls had negative tests. Adjusted vaccine effectiveness (aVE) was calculated using the formula: aVE = (1 − Odds ratio) × 100. Results: During the Delta variant’s predominance, aVE against infection within 12–120 days post-second dose was 64.8 % (BNT162b2) and 59.4 % (mRNA-1273), declining to 21.2 % and 42.2 %, respectively, after 120 days. For the Omicron variant, aVE within 12–120 days post-second dose was 61.1 % (BNT162b2) and 85.1 % (mRNA-1273), decreasing to 36.7 % and 24.9 %, respectively, after 120 days. After a booster dose of mRNA-1273, aVE was 64.0 % (BNT162b2 recipients) and 65.9 % (initial mRNA-1273 recipients). Regardless of variant, aVE for hospitalization prevention after 2 doses was 87.0 % (BNT162b2) and 89.0 % (mRNA-1273). Conclusion: The administration of two doses of Moderna-mRNA-1273 against SARS-CoV-2 in HCWs proved to be highly effective in preventing infections and hospitalizations in the first 120 days after the second dose during the predominance of the Omicron variant. The decline in VE after 120 days since the administration of the second dose was significantly restored by the booster dose administration. This increase in VE was greater for the Pfizer vaccine. COVID-19 hospitalization prevention remained stable with both mRNA vaccines throughout the study period.

Published
2024

15. Individualised perioperative open-lung approach versus standard protective ventilation in abdominal surgery (iPROVE): a randomised controlled trial

Author

Acosta, Jesús, Aguilar, Gerardo, Alberola, María José, Alcón, Amalia, Alonso, Jose M., Alonso, María Dolores, Anaya, Rafael, Argente, María Pilar, Agilaga, Marta, Arocas, Blanca, Asensio, Ana, Ayas, Begoña, Ayuso, Mercedes, Balandrón, Victor, Barrio, María, Bejarano, Natalia, Benítez, Inmaculada, Cabrera, Sergio, Carbonell, Jose A., Carramiñana, Albert, Carrizo, Juan, Cegarra, Virginia, Chamorro, Estefanía, Charco, Pedro, Cruz, Patricia, Daviu, Francisco, De Fez, Mario, De Miguel, Ángeles, Del Río, Elena, Delgado, Carlos, Díaz, Ruben, Díaz, Susana, Díez, Fernando, Dosdá, Rosa, Duca, Alejandro, Etulain, M<ce:sup loc='post">a</ce:sup> Justina, Fernández, Carmen, Franco, Tania, Fuentes, Isabel, Gallego, Clara, Gallego-Casilda, Alberto, Galve, Ana Isabel, Garcés, Cristina, García, Mercedes, García, Pablo, Garrigues, Beatriz, Gilabert, Vicente, González, Domingo, Gutiérrez, Andrea, Hernández, Inmaculada, Izquierdo, Ana, Jurado, Ana, Katime, Antonio, Llamazares, Eduardo, Lardies, Rosa, Lisbona, Cristina, López-Herrera, Daniel, López, Ramiro, Lozano, Angels, Lozano, Elena, Marcos, Jose Miguel, Martin, Silvia, Martínez, Nilda, Martínez, Rocío, Martínez-Pallí, Graciella, Mazzinari, Guido, Miñana, Amanda, Moral, Victoria, Moreno, Tania, Mugarra, Ana, Muñoz, Lorena, Navarro, Jose, Olmedilla, Luis, Olmedo, Jonathan, Ojeda, Nazario, Parera, Ana, Parra, María, Parrilla, Cristina, Pastor, Ernesto, Peña, Natalia, Pérez, Ana María, Pérez, Jose María, Piqueras, Laura, Rico-Feijoo, Jesús, Rodríguez, Rayco, Román, Javier Ignacio, Romero, Antonio, Romero, Carolina, Romero, Esther, Ruiz, Isabel, Sánchez, Ester, Sandín, Francisco, Serralta, Ferran, Socorro, Tania, Soriano, Laura, Tisner, Manuel, Valencia, Lucia, Valls, Paola, Vaquero, Laura, Varón, Viviana, Vila, María, Villazala, Rubén, Villena, Abigail, Zapatero, Sara, Ferrando, Carlos, Soro, Marina, Unzueta, Carmen, Suarez-Sipmann, Fernando, Canet, Jaume, Librero, Julián, Pozo, Natividad, Peiró, Salvador, Llombart, Alicia, León, Irene, India, Inmaculada, Aldecoa, Cesar, Díaz-Cambronero, Oscar, Pestaña, David, Redondo, Francisco J, Garutti, Ignacio, Balust, Jaume, García, Jose I, Ibáñez, Maite, Granell, Manuel, Rodríguez, Aurelio, Gallego, Lucía, de la Matta, Manuel, Gonzalez, Rafael, Brunelli, Andrea, García, Javier, Rovira, Lucas, Barrios, Francisco, Torres, Vicente, Hernández, Samuel, Gracia, Estefanía, Giné, Marta, García, María, García, Nuria, Miguel, Lisset, Sánchez, Sergio, Piñeiro, Patricia, Pujol, Roger, García-del-Valle, Santiago, Valdivia, José, Hernández, María J, Padrón, Oto, Colás, Ana, Puig, Jaume, Azparren, Gonzalo, Tusman, Gerardo, Villar, Jesús, and Belda, Javier

Published
2018
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17. Antibiotic Use in Children – A Cross-National Analysis of 6 Countries

Author

Youngster, Ilan, Avorn, Jerry, Belleudi, Valeria, Cantarutti, Anna, Díez-Domingo, Javier, Kirchmayer, Ursula, Park, Byung-Joo, Peiró, Salvador, Sanfélix-Gimeno, Gabriel, Schröder, Helmut, Schüssel, Katrin, Shin, Ju-Young, Shin, Sun Mi, Simonsen, Gunnar Skov, Blix, Hege Salvesen, Tong, Angela, Trifirò, Gianluca, Ziv-Baran, Tomer, and Kim, Seoyoung C.

Published
2017
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21. Impact of the 2018 revised Pregnancy Prevention Programme by the European Medicines Agency on the use of oral retinoids in females of childbearing age in Denmark, Italy, Netherlands, and Spain: an interrupted time series analysis

Author

Durán, Carlos E., primary, Riera-Arnau, Judit, additional, Abtahi, Shahab, additional, Pajouheshnia, Romin, additional, Hoxhaj, Vjola, additional, Gamba, Magdalena, additional, Alsina, Ema, additional, Martin-Perez, Mar, additional, Garcia-Poza, Patricia, additional, Llorente-Garcia, Ana, additional, Gonzalez-Bermejo, Diana, additional, Ibánez, Luisa, additional, Sabaté, Mònica, additional, Vidal, Xavier, additional, Ballarín, Elena, additional, Sanfélix-Gimeno, Gabriel, additional, Rodríguez-Bernal, Clara, additional, Peiró, Salvador, additional, García-Sempere, Aníbal, additional, Sanchez-Saez, Francisco, additional, Ientile, Valentina, additional, Ingrasciotta, Ylenia, additional, Guarneri, Claudio, additional, Tanaglia, Matilde, additional, Tari, Michele, additional, Herings, Ron, additional, Houben, Eline, additional, Swart-Polinder, Karin, additional, Holthuis, Emily, additional, Huerta, Consuelo, additional, Gini, Rosa, additional, Roberto, Giuseppe, additional, Bartolini, Claudia, additional, Paoletti, Olga, additional, Limoncella, Giorgio, additional, Girardi, Anna, additional, Hyeraci, Giulia, additional, Andersen, Morten, additional, Kristiansen, Sarah Brøgger, additional, Hallgreen, Christine Erikstrup, additional, Klungel, Olaf, additional, and Sturkenboom, Miriam, additional

Published
2023
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22. SARS-CoV-2 adaptive immunity in nursing home residents up to eight months after two doses of the Comirnaty® COVID-19 vaccine

Author

Peiró, Salvador[0000-0002-3902-569X], Vanaclocha, Herme [0000-0002-5655-5924], Comas, Iñaki [0000-0001-5504-9408], Gonzáles-Candelas, Fernando [0000-0002-0879-5798], Giménez, Estela, Albert, Eliseo, Burgos, Javier S., Peiró, Salvador, Salas, Dolores, Vanaclocha, Hermelinda, Limón, Ramón, Alcaraz, María Jesús, Sánchez-Payá, José, Díez-Domingo, Javier, Comas, Iñaki, González-Candelas, Fernando, Peiró, Salvador[0000-0002-3902-569X], Vanaclocha, Herme [0000-0002-5655-5924], Comas, Iñaki [0000-0001-5504-9408], Gonzáles-Candelas, Fernando [0000-0002-0879-5798], Giménez, Estela, Albert, Eliseo, Burgos, Javier S., Peiró, Salvador, Salas, Dolores, Vanaclocha, Hermelinda, Limón, Ramón, Alcaraz, María Jesús, Sánchez-Payá, José, Díez-Domingo, Javier, Comas, Iñaki, and González-Candelas, Fernando

Abstract

There is scant information as to how SARS-CoV-2 antibody and T-cell immune responses elicited by mRNA COVID-19 vaccines evolve in the general population, and in particular in elderly nursing home residents, who are at increased risk of developing severe clinical forms of COVID-19. We read with interest the work by Tré-Hardy and colleagues who reported a significant antibody decrease at around 6 months after full vaccination in healthcare workers, that was more marked in SARS-CoV-2 naïve vaccinees [1]. The authors suggested that in a supply-limited environment, booster dose schemes may be spared for SARS-CoV-2-experienced individuals. The data presented herein extend this observation to elderly nursing home residents. The current prospective cohort study included 680 (478 female; median age, 87 years; range 65–100) of a cohort of 881 nursing home residents initially recruited from a representative sample of Valencian Community nursing homes (n = 13) for assessment of SARS-CoV-2 immune responses at a median of 3 months (3 M) following full-dose Comirnaty® COVID-19 vaccination [2] who were re-examined at a median of 219 days (range, 139–246) after vaccination (7 M). Out of the 680 participants, 238 had been infected by SARS-CoV-2 prior to receiving the first vaccine dose, as recorded in the electronic Valencia Health System Integrated Databases. Two residents contracted the infection (Delta variant, as documented by whole-genome sequencing) between sampling times (3 M and 7 M). The remaining 440 participants were presumably naïve for SARS-CoV-2 at the time of sampling (7 M).

Published
2022

23. Impact of the 2018 revised Pregnancy Prevention Programme by the European Medicines Agency on the use of oral retinoids in females of childbearing age in Denmark, Italy, Netherlands, and Spain: an interrupted time series analysis

Author

Durán, Carlos E, Riera-Arnau, Judit, Abtahi, Shahab, Pajouheshnia, Romin, Hoxhaj, Vjola, Gamba, Magdalena, Alsina, Ema, Martin-Perez, Mar, Garcia-Poza, Patricia, Llorente-Garcia, Ana, Gonzalez-Bermejo, Diana, Ibánez, Luisa, Sabaté, Mònica, Vidal, Xavier, Ballarín, Elena, Sanfélix-Gimeno, Gabriel, Rodríguez-Bernal, Clara, Peiró, Salvador, García-Sempere, Aníbal, Sanchez-Saez, Francisco, Ientile, Valentina, Ingrasciotta, Ylenia, Guarneri, Claudio, Tanaglia, Matilde, Tari, Michele, Herings, Ron, Houben, Eline, Swart-Polinder, Karin, Holthuis, Emily, Huerta, Consuelo, Gini, Rosa, Roberto, Giuseppe, Bartolini, Claudia, Paoletti, Olga, Limoncella, Giorgio, Girardi, Anna, Hyeraci, Giulia, Andersen, Morten, Kristiansen, Sarah Brøgger, Hallgreen, Christine Erikstrup, Klungel, Olaf, Sturkenboom, Miriam, Durán, Carlos E, Riera-Arnau, Judit, Abtahi, Shahab, Pajouheshnia, Romin, Hoxhaj, Vjola, Gamba, Magdalena, Alsina, Ema, Martin-Perez, Mar, Garcia-Poza, Patricia, Llorente-Garcia, Ana, Gonzalez-Bermejo, Diana, Ibánez, Luisa, Sabaté, Mònica, Vidal, Xavier, Ballarín, Elena, Sanfélix-Gimeno, Gabriel, Rodríguez-Bernal, Clara, Peiró, Salvador, García-Sempere, Aníbal, Sanchez-Saez, Francisco, Ientile, Valentina, Ingrasciotta, Ylenia, Guarneri, Claudio, Tanaglia, Matilde, Tari, Michele, Herings, Ron, Houben, Eline, Swart-Polinder, Karin, Holthuis, Emily, Huerta, Consuelo, Gini, Rosa, Roberto, Giuseppe, Bartolini, Claudia, Paoletti, Olga, Limoncella, Giorgio, Girardi, Anna, Hyeraci, Giulia, Andersen, Morten, Kristiansen, Sarah Brøgger, Hallgreen, Christine Erikstrup, Klungel, Olaf, and Sturkenboom, Miriam

Abstract

Background: In March 2018, the European pregnancy prevention programme for oral retinoids was updated as part of risk minimisation measures (RMM), emphasising their contraindication in pregnant women. Objective: To measure the impact of the 2018 revision of the RMMs in Europe by assessing the utilisation patterns of isotretinoin, alitretinoin and acitretin, contraceptive measures, pregnancy testing, discontinuation, and pregnancy occurrence concomitantly with a retinoid prescription. Methods: An interrupted time series (ITS) analysis to compare level and trend changes after the risk minimisation measures implementation was conducted on a cohort of females of childbearing age (12-55 years of age) from January 2010 to December 2020, derived from six electronic health data sources in four countries: Denmark, Netherlands, Spain, and Italy. Monthly utilisation figures (incidence rates [IR], prevalence rates [PR] and proportions) of oral retinoids were calculated, as well as discontinuation rates, contraception coverage, pregnancy testing, and rates of exposed pregnancies to oral retinoids, before and after the 2018 RMMs. Results: From 10,714,182 females of child-bearing age, 88,992 used an oral retinoid at any point during the study period (mean age 18.9-22.2 years old). We found non-significant level and trend changes in incidence or prevalence of retinoid use in females of child-bearing age after the 2018 RMMs. The reason of discontinuation was unknown in >95% of cases. Contraception use showed a significant increase trend in Spain; for other databases this information was limited. Pregnancy testing was hardly recorded thus was not possible to model ITS analyses. After the 2018 RMM, rates of pregnancy occurrence during retinoid use, and start of a retinoid during a pregnancy varied from 0.0 to 0.4, and from 0.2 to 0.8, respectively. Conclusion: This study shows a limited impact of the 2018 RMMs on oral retinoids utilisation patterns among females of child-bearing

Published
2023

24. Conflictos armados y crímenes de lesa humanidad. ¿Por qué persisten?

Author

Universidad de Alicante. Departamento de Enfermería Comunitaria, Medicina Preventiva y Salud Pública e Historia de la Ciencia, Universidad de Alicante. Departamento de Psicología de la Salud, Alguacil, Juan, Negrín, Miguel Ángel, Bermúdez-Tamayo, Clara, Cantarero, David, Carrasco Portiño, Mercedes, Casino, Gonzalo, García Calvente, María del Mar, Hernán, Mariano, Posenato García, Leila, Ruiz-Cantero, María Teresa, Segura, Andreu, Gullón, Pedro, Juárez, Lucero, Errea, María, March, Joan Carles, Marcos-Marcos, Jorge, Mar, Javier, Peiró Pérez, Rosana, Peiró, Salvador, Álvarez-Dardet, Carlos, Universidad de Alicante. Departamento de Enfermería Comunitaria, Medicina Preventiva y Salud Pública e Historia de la Ciencia, Universidad de Alicante. Departamento de Psicología de la Salud, Alguacil, Juan, Negrín, Miguel Ángel, Bermúdez-Tamayo, Clara, Cantarero, David, Carrasco Portiño, Mercedes, Casino, Gonzalo, García Calvente, María del Mar, Hernán, Mariano, Posenato García, Leila, Ruiz-Cantero, María Teresa, Segura, Andreu, Gullón, Pedro, Juárez, Lucero, Errea, María, March, Joan Carles, Marcos-Marcos, Jorge, Mar, Javier, Peiró Pérez, Rosana, Peiró, Salvador, and Álvarez-Dardet, Carlos

Published
2023

25. Impact of the 2018 revised Pregnancy Prevention Programme by the European Medicines Agency on the use of oral retinoids in females of childbearing age in Denmark, Italy, Netherlands, and Spain: an interrupted time series analysis

Author

Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology, PECP - Centre for Pharmacoepidemiology, Durán, Carlos E, Riera-Arnau, Judit, Abtahi, Shahab, Pajouheshnia, Romin, Hoxhaj, Vjola, Gamba, Magdalena, Alsina, Ema, Martin-Perez, Mar, Garcia-Poza, Patricia, Llorente-Garcia, Ana, Gonzalez-Bermejo, Diana, Ibánez, Luisa, Sabaté, Mònica, Vidal, Xavier, Ballarín, Elena, Sanfélix-Gimeno, Gabriel, Rodríguez-Bernal, Clara, Peiró, Salvador, García-Sempere, Aníbal, Sanchez-Saez, Francisco, Ientile, Valentina, Ingrasciotta, Ylenia, Guarneri, Claudio, Tanaglia, Matilde, Tari, Michele, Herings, Ron, Houben, Eline, Swart-Polinder, Karin, Holthuis, Emily, Huerta, Consuelo, Gini, Rosa, Roberto, Giuseppe, Bartolini, Claudia, Paoletti, Olga, Limoncella, Giorgio, Girardi, Anna, Hyeraci, Giulia, Andersen, Morten, Kristiansen, Sarah Brøgger, Hallgreen, Christine Erikstrup, Klungel, Olaf, Sturkenboom, Miriam, Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology, PECP - Centre for Pharmacoepidemiology, Durán, Carlos E, Riera-Arnau, Judit, Abtahi, Shahab, Pajouheshnia, Romin, Hoxhaj, Vjola, Gamba, Magdalena, Alsina, Ema, Martin-Perez, Mar, Garcia-Poza, Patricia, Llorente-Garcia, Ana, Gonzalez-Bermejo, Diana, Ibánez, Luisa, Sabaté, Mònica, Vidal, Xavier, Ballarín, Elena, Sanfélix-Gimeno, Gabriel, Rodríguez-Bernal, Clara, Peiró, Salvador, García-Sempere, Aníbal, Sanchez-Saez, Francisco, Ientile, Valentina, Ingrasciotta, Ylenia, Guarneri, Claudio, Tanaglia, Matilde, Tari, Michele, Herings, Ron, Houben, Eline, Swart-Polinder, Karin, Holthuis, Emily, Huerta, Consuelo, Gini, Rosa, Roberto, Giuseppe, Bartolini, Claudia, Paoletti, Olga, Limoncella, Giorgio, Girardi, Anna, Hyeraci, Giulia, Andersen, Morten, Kristiansen, Sarah Brøgger, Hallgreen, Christine Erikstrup, Klungel, Olaf, and Sturkenboom, Miriam

Published
2023

26. Impact of the 2018 revised Pregnancy Prevention Programme by the European Medicines Agency on the use of oral retinoids in females of childbearing age in Denmark, Italy, Netherlands, and Spain:an interrupted time series analysis

Author

Durán, Carlos E., Riera-Arnau, Judit, Abtahi, Shahab, Pajouheshnia, Romin, Hoxhaj, Vjola, Gamba, Magdalena, Alsina, Ema, Martin-Perez, Mar, Garcia-Poza, Patricia, Llorente-Garcia, Ana, Gonzalez-Bermejo, Diana, Ibánez, Luisa, Sabaté, Mònica, Vidal, Xavier, Ballarín, Elena, Sanfélix-Gimeno, Gabriel, Rodríguez-Bernal, Clara, Peiró, Salvador, García-Sempere, Aníbal, Sanchez-Saez, Francisco, Ientile, Valentina, Ingrasciotta, Ylenia, Guarneri, Claudio, Tanaglia, Matilde, Tari, Michele, Herings, Ron, Houben, Eline, Swart-Polinder, Karin, Holthuis, Emily, Huerta, Consuelo, Gini, Rosa, Roberto, Giuseppe, Bartolini, Claudia, Paoletti, Olga, Limoncella, Giorgio, Girardi, Anna, Hyeraci, Giulia, Andersen, Morten, Kristiansen, Sarah Brøgger, Hallgreen, Christine Erikstrup, Klungel, Olaf, Sturkenboom, Miriam, Durán, Carlos E., Riera-Arnau, Judit, Abtahi, Shahab, Pajouheshnia, Romin, Hoxhaj, Vjola, Gamba, Magdalena, Alsina, Ema, Martin-Perez, Mar, Garcia-Poza, Patricia, Llorente-Garcia, Ana, Gonzalez-Bermejo, Diana, Ibánez, Luisa, Sabaté, Mònica, Vidal, Xavier, Ballarín, Elena, Sanfélix-Gimeno, Gabriel, Rodríguez-Bernal, Clara, Peiró, Salvador, García-Sempere, Aníbal, Sanchez-Saez, Francisco, Ientile, Valentina, Ingrasciotta, Ylenia, Guarneri, Claudio, Tanaglia, Matilde, Tari, Michele, Herings, Ron, Houben, Eline, Swart-Polinder, Karin, Holthuis, Emily, Huerta, Consuelo, Gini, Rosa, Roberto, Giuseppe, Bartolini, Claudia, Paoletti, Olga, Limoncella, Giorgio, Girardi, Anna, Hyeraci, Giulia, Andersen, Morten, Kristiansen, Sarah Brøgger, Hallgreen, Christine Erikstrup, Klungel, Olaf, and Sturkenboom, Miriam

Abstract

Background: In March 2018, the European pregnancy prevention programme for oral retinoids was updated as part of risk minimisation measures (RMM), emphasising their contraindication in pregnant women. Objective: To measure the impact of the 2018 revision of the RMMs in Europe by assessing the utilisation patterns of isotretinoin, alitretinoin and acitretin, contraceptive measures, pregnancy testing, discontinuation, and pregnancy occurrence concomitantly with a retinoid prescription. Methods: An interrupted time series (ITS) analysis to compare level and trend changes after the risk minimisation measures implementation was conducted on a cohort of females of childbearing age (12–55 years of age) from January 2010 to December 2020, derived from six electronic health data sources in four countries: Denmark, Netherlands, Spain, and Italy. Monthly utilisation figures (incidence rates [IR], prevalence rates [PR] and proportions) of oral retinoids were calculated, as well as discontinuation rates, contraception coverage, pregnancy testing, and rates of exposed pregnancies to oral retinoids, before and after the 2018 RMMs. Results: From 10,714,182 females of child-bearing age, 88,992 used an oral retinoid at any point during the study period (mean age 18.9–22.2 years old). We found non-significant level and trend changes in incidence or prevalence of retinoid use in females of child-bearing age after the 2018 RMMs. The reason of discontinuation was unknown in >95% of cases. Contraception use showed a significant increase trend in Spain; for other databases this information was limited. Pregnancy testing was hardly recorded thus was not possible to model ITS analyses. After the 2018 RMM, rates of pregnancy occurrence during retinoid use, and start of a retinoid during a pregnancy varied from 0.0 to 0.4, and from 0.2 to 0.8, respectively. Conclusion: This study shows a limited impact of the 2018 RMMs on oral retinoids utilisation patterns among females of child-bearing

Published
2023

27. Neutralizing antibodies against Omicron BA.4/5 after COVID-19 vaccination in SARS-CoV-2 experienced versus naïve individuals in the general population

Author

European Commission, Consejo Superior de Investigaciones Científicas (España), Camacho, Jorge, Zulaica, Joao, Giménez, Estela, Rusu, Luciana, Velandia-Álvarez, Sebastian, Albert, Eliseo, Peiró, Salvador, Vanaclocha, Hermelinda, Limón, Ramón, Geller, Ron, Navarro, David, Valencian Vaccine Research Program (ProVaVac) study group, European Commission, Consejo Superior de Investigaciones Científicas (España), Camacho, Jorge, Zulaica, Joao, Giménez, Estela, Rusu, Luciana, Velandia-Álvarez, Sebastian, Albert, Eliseo, Peiró, Salvador, Vanaclocha, Hermelinda, Limón, Ramón, Geller, Ron, Navarro, David, and Valencian Vaccine Research Program (ProVaVac) study group

Published
2023

28. A machine learning model for predicting serum neutralizing activity against Omicron SARS-CoV-2 BA.2 and BA.4/5 sublineages in the general population

Author

Instituto de Salud Carlos III, European Commission, Generalitat Valenciana, Consejo Superior de Investigaciones Científicas (España), Camacho, Jorge, Albert, Eliseo, Álvarez-Rodríguez, Beatriz, Rusu, Luciana, Zulaica, Joao, Rodríguez Moreno, Alicia, Peiró, Salvador, Geller, Ron, Navarro, David, Giménez, Estela, Instituto de Salud Carlos III, European Commission, Generalitat Valenciana, Consejo Superior de Investigaciones Científicas (España), Camacho, Jorge, Albert, Eliseo, Álvarez-Rodríguez, Beatriz, Rusu, Luciana, Zulaica, Joao, Rodríguez Moreno, Alicia, Peiró, Salvador, Geller, Ron, Navarro, David, and Giménez, Estela

Abstract

Supervised machine learning (ML) methods have been used to predict antibody responses elicited by COVID-19 vaccines in a variety of clinical settings. Here, we explored the reliability of a ML approach to predict the presence of detectable neutralizing antibody responses (NtAb) against Omicron BA.2 and BA.4/5 sublineages in the general population. Anti-SARS-CoV-2 receptor-binding domain (RBD) total antibodies were measured by the Elecsys® Anti-SARS-CoV-2 S assay (Roche Diagnostics) in all participants. NtAbs against Omicron BA.2 and BA4/5 were measured using a SARS-CoV-2 S pseudotyped neutralization assay in 100 randomly selected sera. A ML model was built using the variables of age, vaccination (number of doses) and SARS-CoV-2 infection status. The model was trained in a cohort (TC) comprising 931 participants and validated in an external cohort (VC) including 787 individuals. Receiver operating characteristics analysis indicated that an anti-SARS-CoV-2 RBD total antibody threshold of 2300 BAU/mL best discriminated between participants either exhibiting or not detectable Omicron BA.2 and Omicron BA.4/5-Spike targeted NtAb responses (87% and 84% precision, respectively). The ML model correctly classified 88% (793/901) of participants in the TC: 717/749 (95.7%) of those displaying ≥2300 BAU/mL and 76/152 (50%) of those exhibiting antibody levels <2300 BAU/mL. The model performed better in vaccinated participants, either with or without prior SARS-CoV-2 infection. The overall accuracy of the ML model in the VC was comparable. Our ML model, based upon a few easily collected parameters for predicting neutralizing activity against Omicron BA.2 and BA.4/5 (sub)variants circumvents the need to perform not only neutralization assays, but also anti-S serological tests, thus potentially saving costs in the setting of large seroprevalence studies.

Published
2023

29. Impact of the 2018 revised Pregnancy Prevention Programme by the European Medicines Agency on the use of oral retinoids in females of childbearing age in Denmark, Italy, Netherlands, and Spain: an interrupted time series analysis

Author

RWE/Causal inference, Epi Infectieziekten Team 2, Data Science & Biostatistiek, Child Health, Durán, Carlos E, Riera-Arnau, Judit, Abtahi, Shahab, Pajouheshnia, Romin, Hoxhaj, Vjola, Gamba, Magdalena, Alsina, Ema, Martin-Perez, Mar, Garcia-Poza, Patricia, Llorente-Garcia, Ana, Gonzalez-Bermejo, Diana, Ibánez, Luisa, Sabaté, Mònica, Vidal, Xavier, Ballarín, Elena, Sanfélix-Gimeno, Gabriel, Rodríguez-Bernal, Clara, Peiró, Salvador, García-Sempere, Aníbal, Sanchez-Saez, Francisco, Ientile, Valentina, Ingrasciotta, Ylenia, Guarneri, Claudio, Tanaglia, Matilde, Tari, Michele, Herings, Ron, Houben, Eline, Swart-Polinder, Karin, Holthuis, Emily, Huerta, Consuelo, Gini, Rosa, Roberto, Giuseppe, Bartolini, Claudia, Paoletti, Olga, Limoncella, Giorgio, Girardi, Anna, Hyeraci, Giulia, Andersen, Morten, Kristiansen, Sarah Brøgger, Hallgreen, Christine Erikstrup, Klungel, Olaf, Sturkenboom, Miriam, RWE/Causal inference, Epi Infectieziekten Team 2, Data Science & Biostatistiek, Child Health, Durán, Carlos E, Riera-Arnau, Judit, Abtahi, Shahab, Pajouheshnia, Romin, Hoxhaj, Vjola, Gamba, Magdalena, Alsina, Ema, Martin-Perez, Mar, Garcia-Poza, Patricia, Llorente-Garcia, Ana, Gonzalez-Bermejo, Diana, Ibánez, Luisa, Sabaté, Mònica, Vidal, Xavier, Ballarín, Elena, Sanfélix-Gimeno, Gabriel, Rodríguez-Bernal, Clara, Peiró, Salvador, García-Sempere, Aníbal, Sanchez-Saez, Francisco, Ientile, Valentina, Ingrasciotta, Ylenia, Guarneri, Claudio, Tanaglia, Matilde, Tari, Michele, Herings, Ron, Houben, Eline, Swart-Polinder, Karin, Holthuis, Emily, Huerta, Consuelo, Gini, Rosa, Roberto, Giuseppe, Bartolini, Claudia, Paoletti, Olga, Limoncella, Giorgio, Girardi, Anna, Hyeraci, Giulia, Andersen, Morten, Kristiansen, Sarah Brøgger, Hallgreen, Christine Erikstrup, Klungel, Olaf, and Sturkenboom, Miriam

Published
2023

31. A machine learning model for predicting serum neutralizing activity against Omicron SARS‐CoV‐2 BA.2 and BA.4/5 sublineages in the general population

Author

Camacho, Jorge, primary, Albert, Eliseo, additional, Álvarez‐Rodríguez, Beatriz, additional, Rusu, Luciana, additional, Zulaica, Joao, additional, Moreno, Alicia Rodríguez, additional, Peiró, Salvador, additional, Geller, Ron, additional, Navarro, David, additional, and Giménez, Estela, additional

Published
2023
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32. Neutralizing antibodies against Omicron BA.4/5 after COVID-19 vaccination in SARS-CoV-2 experienced versus naïve individuals in the general population

Author

Camacho, Jorge, primary, Zulaica, Joao, additional, Giménez, Estela, additional, Rusu, Luciana, additional, Velandia-Álvarez, Sebastian, additional, Albert, Eliseo, additional, Peiró, Salvador, additional, Vanaclocha, Hermelinda, additional, Limón, Ramón, additional, Geller, Ron, additional, and Navarro, David, additional

Published
2023
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39. Conflictos armados y crímenes de lesa humanidad. ¿Por qué persisten?

Author

Alguacil, Juan, primary, Negrín-Hernández, Miguel, additional, Bermúdez-Tamayo, Clara, additional, Cantarero, David, additional, Carrasco-Portiño, Mercedes, additional, Casino, Gonzalo, additional, García-Calvente, Mar, additional, Hernán, Mariano, additional, Posenato-García, Leila, additional, Ruíz-Cantero, María Teresa, additional, Segura, Andreu, additional, Gullón, Pedro, additional, Juárez, Lucero, additional, Errea, María, additional, March, Joan Carles, additional, Marcos-Marcos, Jorge, additional, Mar, Javier, additional, Peiró, Rosanna, additional, Peiró, Salvador, additional, and Álvarez-Dardet, Carlos, additional

Published
2023
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44. Rationale and design of a pragmatic clinical trial to assess the impact of self-monitoring blood pressure at home and self-titration of antihypertensive medication in poorly controlled hypertension: the ADAMPA study protocol

Author

Sanfélix-Genovés, José, Rodríguez-Bernal, Clara L., Marco-Moreno, Irene, Martinez-Ibañez, Patricia, Martinez-Ibañez, Lucía, Bóveda-García, María, Barreira-Franch, Ignacio, Calleja-Del Ser, Mercedes, Borrás-Moreno, Greta, Avelino-Hidalgo, Eugenia, Escrig-Veses, Marina, Lauriano, Margherita, Giménez-Loreiro, Margarita, Bellot-Pujalte, Laura, García-Sempere, Aníbal, Peiró, Salvador, Sanfélix-Gimeno, Gabriel, and ADAMPA group

Published
2018
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48. Side effects during the week after first dose vaccination with four Covid-19 vaccines. Results of the ProVaVac Survey Study with 13,837 people in Spain

Author

Sánchez-Saez, Francisco, primary, Peiró, Salvador, additional, Cuenca, Llanos, additional, Vanaclocha, Hermelinda, additional, Limón, Ramón, additional, Salas, Dolores, additional, Burgos, Javier S., additional, Sánchez-Payá, José, additional, Meneu, Ricard, additional, Díez, Javier, additional, García-Sempere, Aníbal, additional, Navarro, Isabel Hurtado, additional, Rodríguez-Bernal, Clara, additional, Sanfélix-Gimeno, Gabriel, additional, and Navarro, David, additional

Published
2022
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