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397 results on '"Peinado, Héctor"'

1. Cell-specific Extracellular Vesicles and Their miRNA Cargo Released Into the Organ Preservation Solution During Cold Ischemia Storage as Biomarkers for Liver Transplant Outcomes

Author

Vidal-Correoso, Daniel, Mateo, Sandra V., Muñoz-Morales, Ana M., Lucas-Ruiz, Fernando, Jover-Aguilar, Marta, Alconchel, Felipe, Martínez-Alarcón, Laura, Sánchez-Redondo, Sara, Santos, Vanesa, López-López, Víctor, Ríos-Zambudio, Antonio, Cascales, Pedro, Pons, José Antonio, Ramírez, Pablo, Pelegrín, Pablo, Peinado, Héctor, and Baroja-Mazo, Alberto

Published
2024
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3. NGFR regulates stromal cell activation in germinal centers

Author

Hernández-Barranco, Alberto, Santos, Vanesa, Mazariegos, Marina S., Caleiras, Eduardo, Nogués, Laura, Mourcin, Frédéric, Léonard, Simon, Oblet, Christelle, Genebrier, Steve, Rossille, Delphine, Benguría, Alberto, Sanz, Alba, Vázquez, Enrique, Dopazo, Ana, Efeyan, Alejo, Ortega-Molina, Ana, Cogne, Michel, Tarte, Karin, and Peinado, Héctor

Published
2024
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4. MiR-151a: a robust endogenous control for normalizing small extracellular vesicle cargo in human cancer

Author

Burdiel, Miranda, Jiménez, Julia, Rodríguez-Antolín, Carlos, García-Guede, Álvaro, Pernía, Olga, Sastre-Perona, Ana, Rosas-Alonso, Rocío, Colmenarejo, Julián, Rodríguez-Jiménez, Carmen, Diestro, María Dolores, Martínez-Marín, Virginia, Higueras, Oliver, Cruz, Patricia, Losantos-García, Itsaso, Peinado, Héctor, Vera, Olga, de Castro, Javier, and Ibáñez de Cáceres, Inmaculada

Published
2023
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5. Correlation Between Endoglin and Malignant Phenotype in Human Melanoma Cells: Analysis of hsa-mir-214 and hsa-mir-370 in Cells and Their Extracellular Vesicles

Author

Ruiz-Llorente, Lidia, Ruiz-Rodríguez, María Jesús, Savini, Claudia, González-Muñoz, Teresa, Riveiro-Falkenbach, Erica, Rodríguez-Peralto, José L., Peinado, Héctor, Bernabeu, Carmelo, Crusio, Wim E., Series Editor, Dong, Haidong, Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Steinlein, Ortrud, Series Editor, Xiao, Junjie, Series Editor, Simon, Felipe, editor, and Bernabeu, Carmelo, editor

Published
2023
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6. Tumour exosomal CEMIP protein promotes cancer cell colonization in brain metastasis

Author

Rodrigues, Gonçalo, Hoshino, Ayuko, Kenific, Candia M, Matei, Irina R, Steiner, Loïc, Freitas, Daniela, Kim, Han Sang, Oxley, Peter R, Scandariato, Ilana, Casanova-Salas, Irene, Dai, Jinxiang, Badwe, Chaitanya R, Gril, Brunilde, Tešić Mark, Milica, Dill, Brian D, Molina, Henrik, Zhang, Haiying, Benito-Martin, Alberto, Bojmar, Linda, Ararso, Yonathan, Offer, Katharine, LaPlant, Quincey, Buehring, Weston, Wang, Huajuan, Jiang, Xinran, Lu, Tyler M, Liu, Yuan, Sabari, Joshua K, Shin, Sandra J, Narula, Navneet, Ginter, Paula S, Rajasekhar, Vinagolu K, Healey, John H, Meylan, Etienne, Costa-Silva, Bruno, Wang, Shizhen Emily, Rafii, Shahin, Altorki, Nasser Khaled, Rudin, Charles M, Jones, David R, Steeg, Patricia S, Peinado, Héctor, Ghajar, Cyrus M, Bromberg, Jacqueline, de Sousa, Maria, Pisapia, David, and Lyden, David

Subjects
Biochemistry and Cell Biology, Biological Sciences, Cancer, Neurosciences, Rare Diseases, 2.1 Biological and endogenous factors, Aetiology, Animals, Brain, Brain Neoplasms, Cell Line, Tumor, Cell Movement, Cell Proliferation, Chemokine CCL1, Chemokine CXCL1, Cyclooxygenase 2, Endothelial Cells, Exosomes, Gene Expression Regulation, Neoplastic, Humans, Hyaluronoglucosaminidase, Mice, Mice, Inbred C57BL, Mice, Nude, Neoplasm Metastasis, Neovascularization, Pathologic, Signal Transduction, Survival Analysis, Tumor Burden, Tumor Microenvironment, Tumor Necrosis Factor-alpha, Xenograft Model Antitumor Assays, Medical and Health Sciences, Developmental Biology, Biochemistry and cell biology
Abstract

The development of effective therapies against brain metastasis is currently hindered by limitations in our understanding of the molecular mechanisms driving it. Here we define the contributions of tumour-secreted exosomes to brain metastatic colonization and demonstrate that pre-conditioning the brain microenvironment with exosomes from brain metastatic cells enhances cancer cell outgrowth. Proteomic analysis identified cell migration-inducing and hyaluronan-binding protein (CEMIP) as elevated in exosomes from brain metastatic but not lung or bone metastatic cells. CEMIP depletion in tumour cells impaired brain metastasis, disrupting invasion and tumour cell association with the brain vasculature, phenotypes rescued by pre-conditioning the brain microenvironment with CEMIP+ exosomes. Moreover, uptake of CEMIP+ exosomes by brain endothelial and microglial cells induced endothelial cell branching and inflammation in the perivascular niche by upregulating the pro-inflammatory cytokines encoded by Ptgs2, Tnf and Ccl/Cxcl, known to promote brain vascular remodelling and metastasis. CEMIP was elevated in tumour tissues and exosomes from patients with brain metastasis and predicted brain metastasis progression and patient survival. Collectively, our findings suggest that targeting exosomal CEMIP could constitute a future avenue for the prevention and treatment of brain metastasis.

Published
2019

8. Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism

Author

García-Silva, Susana, Benito-Martín, Alberto, Nogués, Laura, Hernández-Barranco, Alberto, Mazariegos, Marina S., Santos, Vanesa, Hergueta-Redondo, Marta, Ximénez-Embún, Pilar, Kataru, Raghu P., Lopez, Ana Amor, Merino, Cristina, Sánchez-Redondo, Sara, Graña-Castro, Osvaldo, Matei, Irina, Nicolás-Avila, José Ángel, Torres-Ruiz, Raúl, Rodríguez-Perales, Sandra, Martínez, Lola, Pérez-Martínez, Manuel, Mata, Gadea, Szumera-Ciećkiewicz, Anna, Kalinowska, Iwona, Saltari, Annalisa, Martínez-Gómez, Julia M., Hogan, Sabrina A., Saragovi, H. Uri, Ortega, Sagrario, Garcia-Martin, Carmen, Boskovic, Jasminka, Levesque, Mitchell P., Rutkowski, Piotr, Hidalgo, Andrés, Muñoz, Javier, Megías, Diego, Mehrara, Babak J., Lyden, David, and Peinado, Héctor

Published
2021
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10. Pre-metastatic niches: organ-specific homes for metastases.

Author

Peinado, Héctor, Zhang, Haiying, Matei, Irina R, Costa-Silva, Bruno, Hoshino, Ayuko, Rodrigues, Goncalo, Psaila, Bethan, Kaplan, Rosandra N, Bromberg, Jacqueline F, Kang, Yibin, Bissell, Mina J, Cox, Thomas R, Giaccia, Amato J, Erler, Janine T, Hiratsuka, Sachie, Ghajar, Cyrus M, and Lyden, David

Subjects
Animals, Humans, Neoplasms, Neoplasm Metastasis, Neoplastic Cells, Circulating, Tumor Microenvironment, Oncology & Carcinogenesis, Medical and Health Sciences
Abstract

It is well established that organs of future metastasis are not passive receivers of circulating tumour cells, but are instead selectively and actively modified by the primary tumour before metastatic spread has even occurred. Sowing the 'seeds' of metastasis requires the action of tumour-secreted factors and tumour-shed extracellular vesicles that enable the 'soil' at distant metastatic sites to encourage the outgrowth of incoming cancer cells. In this Review, we summarize the main processes and new mechanisms involved in the formation of the pre-metastatic niche.

Published
2017

11. Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers

Author

Hoshino, Ayuko, Kim, Han Sang, Bojmar, Linda, Gyan, Kofi Ennu, Cioffi, Michele, Hernandez, Jonathan, Zambirinis, Constantinos P., Rodrigues, Gonçalo, Molina, Henrik, Heissel, Søren, Mark, Milica Tesic, Steiner, Loïc, Benito-Martin, Alberto, Lucotti, Serena, Di Giannatale, Angela, Offer, Katharine, Nakajima, Miho, Williams, Caitlin, Nogués, Laura, Pelissier Vatter, Fanny A., Hashimoto, Ayako, Davies, Alexander E., Freitas, Daniela, Kenific, Candia M., Ararso, Yonathan, Buehring, Weston, Lauritzen, Pernille, Ogitani, Yusuke, Sugiura, Kei, Takahashi, Naoko, Alečković, Maša, Bailey, Kayleen A., Jolissant, Joshua S., Wang, Huajuan, Harris, Ashton, Schaeffer, L. Miles, García-Santos, Guillermo, Posner, Zoe, Balachandran, Vinod P., Khakoo, Yasmin, Raju, G. Praveen, Scherz, Avigdor, Sagi, Irit, Scherz-Shouval, Ruth, Yarden, Yosef, Oren, Moshe, Malladi, Mahathi, Petriccione, Mary, De Braganca, Kevin C., Donzelli, Maria, Fischer, Cheryl, Vitolano, Stephanie, Wright, Geraldine P., Ganshaw, Lee, Marrano, Mariel, Ahmed, Amina, DeStefano, Joe, Danzer, Enrico, Roehrl, Michael H.A., Lacayo, Norman J., Vincent, Theresa C., Weiser, Martin R., Brady, Mary S., Meyers, Paul A., Wexler, Leonard H., Ambati, Srikanth R., Chou, Alexander J., Slotkin, Emily K., Modak, Shakeel, Roberts, Stephen S., Basu, Ellen M., Diolaiti, Daniel, Krantz, Benjamin A., Cardoso, Fatima, Simpson, Amber L., Berger, Michael, Rudin, Charles M., Simeone, Diane M., Jain, Maneesh, Ghajar, Cyrus M., Batra, Surinder K., Stanger, Ben Z., Bui, Jack, Brown, Kristy A., Rajasekhar, Vinagolu K., Healey, John H., de Sousa, Maria, Kramer, Kim, Sheth, Sujit, Baisch, Jeanine, Pascual, Virginia, Heaton, Todd E., La Quaglia, Michael P., Pisapia, David J., Schwartz, Robert, Zhang, Haiying, Liu, Yuan, Shukla, Arti, Blavier, Laurence, DeClerck, Yves A., LaBarge, Mark, Bissell, Mina J., Caffrey, Thomas C., Grandgenett, Paul M., Hollingsworth, Michael A., Bromberg, Jacqueline, Costa-Silva, Bruno, Peinado, Hector, Kang, Yibin, Garcia, Benjamin A., O’Reilly, Eileen M., Kelsen, David, Trippett, Tanya M., Jones, David R., Matei, Irina R., Jarnagin, William R., and Lyden, David

Published
2020
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13. Proteomic profiles of peritoneal-derived small extracellular vesicles correlate with outcome in ovarian cancer patients

Author

Quiralte, Miguel, primary, Barquín, Arantzazu, additional, Yagüe Fernández, Mónica, additional, Navarro, Paloma, additional, Grazioso, Tatiana P., additional, Sevillano, Elena, additional, Rodriguez Moreno, Juan F., additional, Balarezo-Saldivar, Alejandra, additional, Peinado, Héctor, additional, Izquierdo, Elena, additional, Millán, Carlos, additional, López Carrasco, Irene, additional, Prieto, Mario, additional, Madurga de Lacalle, Rodrigo, additional, Fernández-Miranda, Ismael, additional, Ruiz-Llorente, Sergio, additional, and García-Donas, Jesús, additional

Published
2024
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14. Small Extracellular Vesicles Are Key Regulators of Non-cell Autonomous Intercellular Communication in Senescence via the Interferon Protein IFITM3

Author

Borghesan, Michela, Fafián-Labora, Juan, Eleftheriadou, Olga, Carpintero-Fernández, Paula, Paez-Ribes, Marta, Vizcay-Barrena, Gema, Swisa, Avital, Kolodkin-Gal, Dror, Ximénez-Embún, Pilar, Lowe, Robert, Martín-Martín, Belen, Peinado, Hector, Muñoz, Javier, Fleck, Roland A., Dor, Yuval, Ben-Porath, Ittai, Vossenkamper, Anna, Muñoz-Espin, Daniel, and O’Loghlen, Ana

Published
2019
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15. Studying the Fate of Tumor Extracellular Vesicles at High Spatiotemporal Resolution Using the Zebrafish Embryo

Author

Hyenne, Vincent, Ghoroghi, Shima, Collot, Mayeul, Bons, Joanna, Follain, Gautier, Harlepp, Sébastien, Mary, Benjamin, Bauer, Jack, Mercier, Luc, Busnelli, Ignacio, Lefebvre, Olivier, Fekonja, Nina, Garcia-Leon, Maria J., Machado, Pedro, Delalande, François, López, Ana Amor, Silva, Susana Garcia, Verweij, Frederik J., van Niel, Guillaume, Djouad, Farida, Peinado, Héctor, Carapito, Christine, Klymchenko, Andrey S., and Goetz, Jacky G.

Published
2019
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18. Circulating tumor extracellular vesicles to monitor metastatic prostate cancer genomics and transcriptomic evolution

Author

Casanova-Salas, Irene, Aguilar, Daniel, Cordoba-Terreros, Sarai, Agundez, Laura, Brandariz, Julian, Herranz, Nicolas, Mas, Alba, Gonzalez, Macarena, Morales-Barrera, Rafael, Sierra, Alexandre, Soriano-Navarro, Mario, Cresta, Pablo, Mir, Gisela, Simonetti, Sara, Rodrigues, Gonçalo, Arce-Gallego, Sara, Delgado-Serrano, Luisa, Agustí, Irene, Castellano-Sanz, Elena, Mast, Richard, de Albert, Matias, Celma, Ana, Santamaria, Anna, Gonzalez, Lucila, Castro, Natalia, Suanes, Maria del Mar, Hernández-Losa, Javier, Nonell, Lara, Peinado, Hector, Carles, Joan, and Mateo, Joaquin

Published
2024
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21. Supplementary Data 3 from Endoglin, a Novel Biomarker and Therapeutical Target to Prevent Malignant Peripheral Nerve Sheath Tumor Growth and Metastasis

Author

González-Muñoz, Teresa, primary, Di Giannatale, Angela, primary, García-Silva, Susana, primary, Santos, Vanesa, primary, Sánchez-Redondo, Sara, primary, Savini, Claudia, primary, Graña-Castro, Osvaldo, primary, Blanco-Aparicio, Carmen, primary, Fischer, Suzanne, primary, De Wever, Olivier, primary, Creus-Bachiller, Edgar, primary, Ortega-Bertran, Sara, primary, Pisapia, David J., primary, Rodríguez-Peralto, Jose L., primary, Fernández-Rodríguez, Juana, primary, Pérez-Portabella, Cleofé Romagosa, primary, Alaggio, Rita, primary, Benassi, Maria Serena, primary, Pazzaglia, Laura, primary, Scotlandi, Katia, primary, Ratner, Nancy, primary, Yohay, Kaleb, primary, Theuer, Charles P., primary, and Peinado, Héctor, primary

Published
2023
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22. Supplementary Data 2 from Endoglin, a Novel Biomarker and Therapeutical Target to Prevent Malignant Peripheral Nerve Sheath Tumor Growth and Metastasis

Author

González-Muñoz, Teresa, primary, Di Giannatale, Angela, primary, García-Silva, Susana, primary, Santos, Vanesa, primary, Sánchez-Redondo, Sara, primary, Savini, Claudia, primary, Graña-Castro, Osvaldo, primary, Blanco-Aparicio, Carmen, primary, Fischer, Suzanne, primary, De Wever, Olivier, primary, Creus-Bachiller, Edgar, primary, Ortega-Bertran, Sara, primary, Pisapia, David J., primary, Rodríguez-Peralto, Jose L., primary, Fernández-Rodríguez, Juana, primary, Pérez-Portabella, Cleofé Romagosa, primary, Alaggio, Rita, primary, Benassi, Maria Serena, primary, Pazzaglia, Laura, primary, Scotlandi, Katia, primary, Ratner, Nancy, primary, Yohay, Kaleb, primary, Theuer, Charles P., primary, and Peinado, Héctor, primary

Published
2023
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23. Suppl. Figure 6 from Endoglin, a Novel Biomarker and Therapeutical Target to Prevent Malignant Peripheral Nerve Sheath Tumor Growth and Metastasis

Author

González-Muñoz, Teresa, primary, Di Giannatale, Angela, primary, García-Silva, Susana, primary, Santos, Vanesa, primary, Sánchez-Redondo, Sara, primary, Savini, Claudia, primary, Graña-Castro, Osvaldo, primary, Blanco-Aparicio, Carmen, primary, Fischer, Suzanne, primary, De Wever, Olivier, primary, Creus-Bachiller, Edgar, primary, Ortega-Bertran, Sara, primary, Pisapia, David J., primary, Rodríguez-Peralto, Jose L., primary, Fernández-Rodríguez, Juana, primary, Pérez-Portabella, Cleofé Romagosa, primary, Alaggio, Rita, primary, Benassi, Maria Serena, primary, Pazzaglia, Laura, primary, Scotlandi, Katia, primary, Ratner, Nancy, primary, Yohay, Kaleb, primary, Theuer, Charles P., primary, and Peinado, Héctor, primary

Published
2023
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24. Suppl. Figure 5 from Endoglin, a Novel Biomarker and Therapeutical Target to Prevent Malignant Peripheral Nerve Sheath Tumor Growth and Metastasis

Author

González-Muñoz, Teresa, primary, Di Giannatale, Angela, primary, García-Silva, Susana, primary, Santos, Vanesa, primary, Sánchez-Redondo, Sara, primary, Savini, Claudia, primary, Graña-Castro, Osvaldo, primary, Blanco-Aparicio, Carmen, primary, Fischer, Suzanne, primary, De Wever, Olivier, primary, Creus-Bachiller, Edgar, primary, Ortega-Bertran, Sara, primary, Pisapia, David J., primary, Rodríguez-Peralto, Jose L., primary, Fernández-Rodríguez, Juana, primary, Pérez-Portabella, Cleofé Romagosa, primary, Alaggio, Rita, primary, Benassi, Maria Serena, primary, Pazzaglia, Laura, primary, Scotlandi, Katia, primary, Ratner, Nancy, primary, Yohay, Kaleb, primary, Theuer, Charles P., primary, and Peinado, Héctor, primary

Published
2023
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25. Suppl. Figure 1 from Endoglin, a Novel Biomarker and Therapeutical Target to Prevent Malignant Peripheral Nerve Sheath Tumor Growth and Metastasis

Author

González-Muñoz, Teresa, primary, Di Giannatale, Angela, primary, García-Silva, Susana, primary, Santos, Vanesa, primary, Sánchez-Redondo, Sara, primary, Savini, Claudia, primary, Graña-Castro, Osvaldo, primary, Blanco-Aparicio, Carmen, primary, Fischer, Suzanne, primary, De Wever, Olivier, primary, Creus-Bachiller, Edgar, primary, Ortega-Bertran, Sara, primary, Pisapia, David J., primary, Rodríguez-Peralto, Jose L., primary, Fernández-Rodríguez, Juana, primary, Pérez-Portabella, Cleofé Romagosa, primary, Alaggio, Rita, primary, Benassi, Maria Serena, primary, Pazzaglia, Laura, primary, Scotlandi, Katia, primary, Ratner, Nancy, primary, Yohay, Kaleb, primary, Theuer, Charles P., primary, and Peinado, Héctor, primary

Published
2023
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26. Supplementary Data 1 from Endoglin, a Novel Biomarker and Therapeutical Target to Prevent Malignant Peripheral Nerve Sheath Tumor Growth and Metastasis

Author

González-Muñoz, Teresa, primary, Di Giannatale, Angela, primary, García-Silva, Susana, primary, Santos, Vanesa, primary, Sánchez-Redondo, Sara, primary, Savini, Claudia, primary, Graña-Castro, Osvaldo, primary, Blanco-Aparicio, Carmen, primary, Fischer, Suzanne, primary, De Wever, Olivier, primary, Creus-Bachiller, Edgar, primary, Ortega-Bertran, Sara, primary, Pisapia, David J., primary, Rodríguez-Peralto, Jose L., primary, Fernández-Rodríguez, Juana, primary, Pérez-Portabella, Cleofé Romagosa, primary, Alaggio, Rita, primary, Benassi, Maria Serena, primary, Pazzaglia, Laura, primary, Scotlandi, Katia, primary, Ratner, Nancy, primary, Yohay, Kaleb, primary, Theuer, Charles P., primary, and Peinado, Héctor, primary

Published
2023
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27. Suppl. Figure 4 from Endoglin, a Novel Biomarker and Therapeutical Target to Prevent Malignant Peripheral Nerve Sheath Tumor Growth and Metastasis

Author

González-Muñoz, Teresa, primary, Di Giannatale, Angela, primary, García-Silva, Susana, primary, Santos, Vanesa, primary, Sánchez-Redondo, Sara, primary, Savini, Claudia, primary, Graña-Castro, Osvaldo, primary, Blanco-Aparicio, Carmen, primary, Fischer, Suzanne, primary, De Wever, Olivier, primary, Creus-Bachiller, Edgar, primary, Ortega-Bertran, Sara, primary, Pisapia, David J., primary, Rodríguez-Peralto, Jose L., primary, Fernández-Rodríguez, Juana, primary, Pérez-Portabella, Cleofé Romagosa, primary, Alaggio, Rita, primary, Benassi, Maria Serena, primary, Pazzaglia, Laura, primary, Scotlandi, Katia, primary, Ratner, Nancy, primary, Yohay, Kaleb, primary, Theuer, Charles P., primary, and Peinado, Héctor, primary

Published
2023
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28. Suppl. Figure 3 from Endoglin, a Novel Biomarker and Therapeutical Target to Prevent Malignant Peripheral Nerve Sheath Tumor Growth and Metastasis

Author

González-Muñoz, Teresa, primary, Di Giannatale, Angela, primary, García-Silva, Susana, primary, Santos, Vanesa, primary, Sánchez-Redondo, Sara, primary, Savini, Claudia, primary, Graña-Castro, Osvaldo, primary, Blanco-Aparicio, Carmen, primary, Fischer, Suzanne, primary, De Wever, Olivier, primary, Creus-Bachiller, Edgar, primary, Ortega-Bertran, Sara, primary, Pisapia, David J., primary, Rodríguez-Peralto, Jose L., primary, Fernández-Rodríguez, Juana, primary, Pérez-Portabella, Cleofé Romagosa, primary, Alaggio, Rita, primary, Benassi, Maria Serena, primary, Pazzaglia, Laura, primary, Scotlandi, Katia, primary, Ratner, Nancy, primary, Yohay, Kaleb, primary, Theuer, Charles P., primary, and Peinado, Héctor, primary

Published
2023
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29. Data from Endoglin, a Novel Biomarker and Therapeutical Target to Prevent Malignant Peripheral Nerve Sheath Tumor Growth and Metastasis

Author

González-Muñoz, Teresa, primary, Di Giannatale, Angela, primary, García-Silva, Susana, primary, Santos, Vanesa, primary, Sánchez-Redondo, Sara, primary, Savini, Claudia, primary, Graña-Castro, Osvaldo, primary, Blanco-Aparicio, Carmen, primary, Fischer, Suzanne, primary, De Wever, Olivier, primary, Creus-Bachiller, Edgar, primary, Ortega-Bertran, Sara, primary, Pisapia, David J., primary, Rodríguez-Peralto, Jose L., primary, Fernández-Rodríguez, Juana, primary, Pérez-Portabella, Cleofé Romagosa, primary, Alaggio, Rita, primary, Benassi, Maria Serena, primary, Pazzaglia, Laura, primary, Scotlandi, Katia, primary, Ratner, Nancy, primary, Yohay, Kaleb, primary, Theuer, Charles P., primary, and Peinado, Héctor, primary

Published
2023
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30. Suppl. Figure 2 from Endoglin, a Novel Biomarker and Therapeutical Target to Prevent Malignant Peripheral Nerve Sheath Tumor Growth and Metastasis

Author

González-Muñoz, Teresa, primary, Di Giannatale, Angela, primary, García-Silva, Susana, primary, Santos, Vanesa, primary, Sánchez-Redondo, Sara, primary, Savini, Claudia, primary, Graña-Castro, Osvaldo, primary, Blanco-Aparicio, Carmen, primary, Fischer, Suzanne, primary, De Wever, Olivier, primary, Creus-Bachiller, Edgar, primary, Ortega-Bertran, Sara, primary, Pisapia, David J., primary, Rodríguez-Peralto, Jose L., primary, Fernández-Rodríguez, Juana, primary, Pérez-Portabella, Cleofé Romagosa, primary, Alaggio, Rita, primary, Benassi, Maria Serena, primary, Pazzaglia, Laura, primary, Scotlandi, Katia, primary, Ratner, Nancy, primary, Yohay, Kaleb, primary, Theuer, Charles P., primary, and Peinado, Héctor, primary

Published
2023
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31. Platelet-Derived Extracellular Vesicles as Lipid Carriers in Severe Allergic Inflammation

Author

Couto-Rodriguez, Alba, primary, Villaseñor, Alma, additional, Pablo-Torres, Carmela, additional, Obeso, David, additional, Rey-Stolle, María Fernanda, additional, Peinado, Héctor, additional, Bueno, José Luis, additional, Reaño-Martos, Mar, additional, Iglesias Cadarso, Alfredo, additional, Gomez-Casado, Cristina, additional, Barbas, Coral, additional, Barber, Domingo, additional, Escribese, María M., additional, and Izquierdo, Elena, additional

Published
2023
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34. Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation

Author

Zhang, Haiying, Freitas, Daniela, Kim, Han Sang, Fabijanic, Kristina, Li, Zhong, Chen, Haiyan, Mark, Milica Tesic, Molina, Henrik, Martin, Alberto Benito, Bojmar, Linda, Fang, Justin, Rampersaud, Sham, Hoshino, Ayuko, Matei, Irina, Kenific, Candia M., Nakajima, Miho, Mutvei, Anders Peter, Sansone, Pasquale, Buehring, Weston, Wang, Huajuan, Jimenez, Juan Pablo, Cohen-Gould, Leona, Paknejad, Navid, Brendel, Matthew, Manova-Todorova, Katia, Magalhães, Ana, Ferreira, José Alexandre, Osório, Hugo, Silva, André M., Massey, Ashish, Cubillos-Ruiz, Juan R., Galletti, Giuseppe, Giannakakou, Paraskevi, Cuervo, Ana Maria, Blenis, John, Schwartz, Robert, Brady, Mary Sue, Peinado, Héctor, Bromberg, Jacqueline, Matsui, Hiroshi, Reis, Celso A., and Lyden, David

Published
2018
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35. Endoglin, a Novel Biomarker and Therapeutical Target to Prevent Malignant Peripheral Nerve Sheath Tumor Growth and Metastasis

Author

González-Muñoz, Teresa, primary, Di Giannatale, Angela, additional, García-Silva, Susana, additional, Santos, Vanesa, additional, Sánchez-Redondo, Sara, additional, Savini, Claudia, additional, Graña-Castro, Osvaldo, additional, Blanco-Aparicio, Carmen, additional, Fischer, Suzanne, additional, De Wever, Olivier, additional, Creus-Bachiller, Edgar, additional, Ortega-Bertran, Sara, additional, Pisapia, David J., additional, Rodríguez-Peralto, Jose L., additional, Fernández-Rodríguez, Juana, additional, Pérez-Portabella, Cleofé Romagosa, additional, Alaggio, Rita, additional, Benassi, Maria Serena, additional, Pazzaglia, Laura, additional, Scotlandi, Katia, additional, Ratner, Nancy, additional, Yohay, Kaleb, additional, Theuer, Charles P., additional, and Peinado, Héctor, additional

Published
2023
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38. El proyecto Gamnatóric. La creación y el uso de videojuegos narrativos como herramienta de aprendizaje para estudiantes de Historia Moderna e Ingeniería Multimedia

Author

Universidad de Alicante. Departamento de Historia Medieval, Historia Moderna y Ciencias y Técnicas Historiográficas, Universidad de Alicante. Departamento de Lenguajes y Sistemas Informáticos, Universidad de Alicante. Departamento de Humanidades Contemporáneas, Carrasco-Rodríguez, Antonio, Navarro Colorado, Borja, Zurita, Rafael, Torregrosa Peinado, Héctor, López Pinel, María Luisa, Pérez-Llorca, Juan, Universidad de Alicante. Departamento de Historia Medieval, Historia Moderna y Ciencias y Técnicas Historiográficas, Universidad de Alicante. Departamento de Lenguajes y Sistemas Informáticos, Universidad de Alicante. Departamento de Humanidades Contemporáneas, Carrasco-Rodríguez, Antonio, Navarro Colorado, Borja, Zurita, Rafael, Torregrosa Peinado, Héctor, López Pinel, María Luisa, and Pérez-Llorca, Juan

Abstract

El presente proyecto propone al alumnado universitario una estrategia docente basada en el Aprendizaje Basado en Juegos (ABJ), y evalúa su eficacia para incrementar la motivación y promover el desarrollo de habilidades y la adquisición de conocimientos. En la enseñanza superior de la Historia apenas existen experiencias de aprendizaje basadas en la creación de videojuegos. En la de la Ingeniería Multimedia, sí, pero los videojuegos desarrollados por el estudiantado suelen descuidar las narrativas, en favor de las mecánicas. Gamnatóric tiene como objetivos: tutelar el desarrollo de videojuegos narrativos por parte del alumnado de los dos citados grados; utilizar juegos narrativos ya creados en actividades prácticas; desarrollar un videojuego narrativo de base histórica para su utilización docente; y evaluar las actividades realizadas. El proyecto ha sido desarrollado en tres fases: diseño, implementación y evaluación. En la primera, planificamos las actividades prácticas de creación y uso de videojuegos, y especificamos las líneas maestras del videojuego creado por el equipo. En la segunda, pusimos en marcha las actividades de creación y uso de videojuegos, y desarrollamos nuestro juego utilizando herramientas como Twine, Moodle y Google Sheet. Y en la tercera, realizamos una encuesta con Google Forms y entrevistas personales. Los participantes en el proyecto han sido estudiantes de diversos cursos de los dos citados Grados. Durante el desarrollo de la iniciativa fueron creados 113 juegos narrativos, evaluados positivamente por los docentes. Además, el alumnado valoró también positivamente la experiencia de crear un videojuego didáctico de este tipo. 69 estudiantes aprendieron con juegos narrativos creados por el profesorado y consideraron positiva la experiencia. Y los tres alumnos participantes en la creación del juego, junto a los docentes del proyecto, también valoraron muy positivamente la experiencia de aprendizaje. Por tanto, los resultados de la iniciativa pu

Published
2023

39. Neuronal Prosurvival Role of Ceramide Synthase 2 by Olidogendrocyte-to-Neuron Extracellular Vesicle Transfer

Author

Ministerio de Ciencia e Innovación (España), Agencia Estatal de Investigación (España), European Commission, CSIC - Plataforma Temática Interdisciplinar del CSIC Neuroenvejecimiento (PTI NeuroAging+), Casadomé-Perales, Álvaro, Naya, Sara, Fernández-Martínez, Elisa, Mille, Bea G, Guerrero-Valero, Marta, Peinado, Héctor, Guix, Francesc X, Dotti, Carlos G, Palomer, Ernest, Ministerio de Ciencia e Innovación (España), Agencia Estatal de Investigación (España), European Commission, CSIC - Plataforma Temática Interdisciplinar del CSIC Neuroenvejecimiento (PTI NeuroAging+), Casadomé-Perales, Álvaro, Naya, Sara, Fernández-Martínez, Elisa, Mille, Bea G, Guerrero-Valero, Marta, Peinado, Héctor, Guix, Francesc X, Dotti, Carlos G, and Palomer, Ernest

Abstract

Ageing is associated with notorious alterations in neurons, i.e., in gene expression, mitochondrial function, membrane degradation or intercellular communication. However, neurons live for the entire lifespan of the individual. One of the reasons why neurons remain functional in elderly people is survival mechanisms prevail over death mechanisms. While many signals are either pro-survival or pro-death, others can play both roles. Extracellular vesicles (EVs) can signal both pro-toxicity and survival. We used young and old animals, primary neuronal and oligodendrocyte cultures and neuroblastoma and oligodendrocytic lines. We analysed our samples using a combination of proteomics and artificial neural networks, biochemistry and immunofluorescence approaches. We found an age-dependent increase in ceramide synthase 2 (CerS2) in cortical EVs, expressed by oligodendrocytes. In addition, we show that CerS2 is present in neurons via the uptake of oligodendrocyte-derived EVs. Finally, we show that age-associated inflammation and metabolic stress favour CerS2 expression and that oligodendrocyte-derived EVs loaded with CerS2 lead to the expression of the antiapoptotic factor Bcl2 in inflammatory conditions. Our study shows that intercellular communication is altered in the ageing brain, which favours neuronal survival through the transfer of oligodendrocyte-derived EVs containing CerS2.

Published
2023

40. Figure S8 from Specific Activation of the CD271 Intracellular Domain in Combination with Chemotherapy or Targeted Therapy Inhibits Melanoma Progression

Author

Saltari, Annalisa, primary, Dzung, Andreas, primary, Quadri, Marika, primary, Tiso, Natascia, primary, Facchinello, Nicola, primary, Hernández-Barranco, Alberto, primary, Garcia-Silva, Susana, primary, Nogués, Laura, primary, Stoffel, Corinne Isabelle, primary, Cheng, Phil F., primary, Turko, Patrick, primary, Eichhoff, Ossia M., primary, Truzzi, Francesca, primary, Marconi, Alessandra, primary, Pincelli, Carlo, primary, Peinado, Héctor, primary, Dummer, Reinhard, primary, and Levesque, Mitchell P., primary

Published
2023
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41. Data from Specific Activation of the CD271 Intracellular Domain in Combination with Chemotherapy or Targeted Therapy Inhibits Melanoma Progression

Author

Saltari, Annalisa, primary, Dzung, Andreas, primary, Quadri, Marika, primary, Tiso, Natascia, primary, Facchinello, Nicola, primary, Hernández-Barranco, Alberto, primary, Garcia-Silva, Susana, primary, Nogués, Laura, primary, Stoffel, Corinne Isabelle, primary, Cheng, Phil F., primary, Turko, Patrick, primary, Eichhoff, Ossia M., primary, Truzzi, Francesca, primary, Marconi, Alessandra, primary, Pincelli, Carlo, primary, Peinado, Héctor, primary, Dummer, Reinhard, primary, and Levesque, Mitchell P., primary

Published
2023
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43. Supplementary Figures 1-4, Tables 1-2 from Genetic Profiling of Epithelial Cells Expressing E-Cadherin Repressors Reveals a Distinct Role for Snail, Slug, and E47 Factors in Epithelial-Mesenchymal Transition

Author

Moreno-Bueno, Gema, primary, Cubillo, Eva, primary, Sarrió, David, primary, Peinado, Héctor, primary, Rodríguez-Pinilla, Socorro María, primary, Villa, Sonia, primary, Bolós, Victoria, primary, Jordá, Mireia, primary, Fabra, Angels, primary, Portillo, Francisco, primary, Palacios, José, primary, and Cano, Amparo, primary

Published
2023
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48. Data from Genetic Profiling of Epithelial Cells Expressing E-Cadherin Repressors Reveals a Distinct Role for Snail, Slug, and E47 Factors in Epithelial-Mesenchymal Transition

Author

Moreno-Bueno, Gema, primary, Cubillo, Eva, primary, Sarrió, David, primary, Peinado, Héctor, primary, Rodríguez-Pinilla, Socorro María, primary, Villa, Sonia, primary, Bolós, Victoria, primary, Jordá, Mireia, primary, Fabra, Angels, primary, Portillo, Francisco, primary, Palacios, José, primary, and Cano, Amparo, primary

Published
2023
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