18 results on '"Pei-pei, Huang"'
Search Results
2. Association between lifestyle, gender and risk for developing end-stage renal failure in IgA nephropathy: a case-control study within 10 years
- Author
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Pei Pei Huang, Dan Hua Shu, Zhen Su, Sheng Nan Luo, Fei Fei Xu, and Fan Lin
- Subjects
alcohol drinking ,exercise ,smoking ,iga ,renal failure ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Purpose: To investigate the potential association between lifestyles, including cigarette smoking, alcohol consumption, and physical exercise at the time of biopsy and the risk for developing end-stage renal failure (ESRF) among IgA nephropathy (IgAN) patients within 10 years. Methods: A case–control study was carried out. Seventy-seven ESRF patients with the primary cause of IgAN were enrolled as cases. Seventy-seven IgAN patients who had not progressed to ESRF after being diagnosed for over 10 years served as controls. Smoking, alcohol consumption and physical exercise related data and baseline clinical features were collected from their medical records and confirmed by phone calls. Results: The case group had higher proportions of males, smokers, drinkers, and physical inactivity individuals than the controls had. Alcohol drinking history (/1 year, OR 1.32, p
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- 2019
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3. Improving the Efficiency of Medication Reconciliation in Two Taiwanese Hospitals by Using the Taiwan National Health Insurance PharmaCloud Medication System
- Author
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Pei-Pei Huang, Samantha Yun-Kai Poon, Shao-Hsuan Chang, Chien-Wen Kuo, Ming-Wen Chien, Chien-Chih Chen, and Shao-Chin Chiang
- Subjects
International Journal of General Medicine ,General Medicine - Abstract
Pei-Pei Huang,1,* Samantha Yun-Kai Poon,2,* Shao-Hsuan Chang,3 Chien-Wen Kuo,4 Ming-Wen Chien,1 Chien-Chih Chen,5 Shao-Chin Chiang2,6 1Division of Outpatient Pharmacy, Department of Pharmacy, Cheng Hsin General Hospital, Taipei, Taiwan; 2Department of Pharmacy, College of Pharmaceutical Sciences, National Yang Ming Chiao Tung University (Yang Ming Campus), Taipei, Taiwan; 3Department of Pharmaceutical Outcomes and Policy, College of Pharmacy, University of Florida, Gainesville, FL, USA; 4Department of Pharmacy, Cheng Hsin General Hospital, Taipei, Taiwan; 5Division of Colorectal Surgery, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan; 6Department of Pharmacy, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan*These authors contributed equally to this workCorrespondence: Shao-Chin Chiang, Department of Pharmacy, College of Pharmaceutical Sciences, National Yang Ming Chiao Tung University (Yang Ming Campus), Taipei, Taiwan, Tel +886-983641216, Email scchiang316@nycu.edu.tw; scchiang@kfsyscc.orgPurpose: Medication reconciliation (MedRec) is a process to ensure complete and accurate communication of patient medication information throughout care transitions to prevent medication errors. Hospitals in Taiwan have stride to implement a universal protocol for MedRec. To establish a feasible protocol indigenously, the World Health Organization (WHO) protocol was incorporated with the Taiwan National Health Insurance (NHI) PharmaCloud patient medication profile. The efficiency and error detection capability of this modified protocol was evaluated in two hospitals.Methods: A prospective, non-randomized, unblinded, multicenter cohort study was conducted. Subjects were recruited among patients admitted for colorectal or orthopedic surgery with at least 4 or more chronic drugs. To obtain the best possible medication history (BPMH), the control group was conducted according to the WHO protocol, and the experimental group used the modified WHO protocol with the medication data from the PharmaCloud system. The time spent on the two protocols was recorded. Admission and discharge orders were reconciled against the BPMH to identify any discrepancies. Discrepancies were evaluated by appropriateness, prescribing intentions, and types of inappropriateness. The levels of potential harm were classified for inappropriate discrepancies.Results: The mean time to obtain BPMH in the control group was 34.3± 10.8 minutes and in the experimental group 27.5± 11.5 minutes (P = 0.01). The experimental group had more subjects with discrepancies (87.9%) than the control (58.3%) (p < 0.001). The discrepancies in both admission and discharge orders for the experimental group (84.5 and 67.2%) were higher than those of the control (47.9 and 37.5%). Many inappropriate discrepancies were classified as the potential harm of level 2 (77.8%).Conclusion: Through the establishment of BPMH with the medication data from the Taiwan NHI PharmaCloud, MedRec could be achieved with greater efficiency and error detection capability in both the admission and discharge order validation processes.Keywords: medication reconciliation, prescription discrepancy, PharmaCloud, best possible medication history, BPMH
- Published
- 2023
4. Neuroanatomy and Functional Connectivity in Patients with Parkinson's Disease with or without Restless Legs Syndrome
- Author
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Qiu Ling Zang, Jin Hua Zheng, Jian Jun Ma, Qi Zhang, Pei Pei Huang, Nan Nan Shen, and Wang Miao
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Neurology ,Neurology (clinical) - Abstract
Restless legs syndrome (RLS) is a common non-motor symptom in Parkinson's disease (PD), but its pathogenesis remains unclear. This study aimed to explore the potential neural substrates of RLS in a large sample of patients with PD.A total of 42 patients with PD with RLS and 124 patients with PD without RLS were prospectively recruited at our hospital between February 2019 and October 2020 and underwent structural and resting-state functional magnetic resonance imaging. Differences between the two patient groups were assessed using voxel-based morphometry and functional connectivity analysis. PD duration, Part III of the Movement Disorder Society's Unified Parkinson's Disease Rating Scale (MDS-UPDRS-III) score, and levodopa equivalent daily dose were treated as covariates.Patients with PD with RLS had significantly larger gray matter volume in the bilateral posterior cingulate cortex than patients with PD without RLS (FDR-adjusted P 0.05). Compared to patients without RLS, those with RLS had significantly lower functional connectivity between the left central opercular cortex and the bilateral precentral gyri and postcentral gyri (FDR-adjusted P 0.001).Our study provides the first evidence that in patients with PD, RLS is associated with significantly larger gray matter volume in the posterior cingulate cortex and lower resting-state functional connectivity within the sensorimotor network. Our results may help clarify the pathophysiology of RLS in PD and identify possible therapeutic targets.
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- 2022
5. Two Novel Zn(II) Coordination Polymers Constructed by the Same Dicarboxylate and Different Bis-Imidazole As Co-ligand: Syntheses, Crystal Structures and Properties
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Yan-Hong Gao, Pei-Pei Huang, Hai-Tao Xu, Pei Huang, Bo Liu, Jiu-Fu Lu, and Hong-Guang Ge
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Inorganic Chemistry ,Organic Chemistry ,Spectroscopy ,Analytical Chemistry - Published
- 2022
6. Crystal Structure of 1-(3-Carboxyphenyl)-5-Methyl-4-Oxo-1,4-Dihydropyridazine-3-Carboxylic Acid and Its Two Metal Coordination Polymers
- Author
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Jia-Hao Gao, Pei-Pei Huang, Jia-Xin Wang, Bo Tang, Hai-Tao Xu, Quan Liu, Jiu-Fu Lu, Si-Yu Yue, and Hong-Guang Ge
- Published
- 2022
7. Association between lifestyle, gender and risk for developing end-stage renal failure in IgA nephropathy: a case-control study within 10 years
- Author
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Dan Hua Shu, Pei Pei Huang, Fan Lin, Fei Fei Xu, Zhen Su, and Sheng Nan Luo
- Subjects
Adult ,Male ,medicine.medical_specialty ,renal failure ,Alcohol Drinking ,Biopsy ,030232 urology & nephrology ,Physical exercise ,030204 cardiovascular system & hematology ,Critical Care and Intensive Care Medicine ,urologic and male genital diseases ,smoking ,Nephropathy ,03 medical and health sciences ,0302 clinical medicine ,Sex Factors ,Cigarette smoking ,Risk Factors ,Internal medicine ,medicine ,Humans ,Association (psychology) ,Life Style ,Retrospective Studies ,medicine.diagnostic_test ,exercise ,business.industry ,Case-control study ,Glomerulonephritis, IGA ,General Medicine ,Middle Aged ,medicine.disease ,Diseases of the genitourinary system. Urology ,Nephrology ,End stage renal failure ,Clinical Study ,Disease Progression ,Kidney Failure, Chronic ,Female ,RC870-923 ,business ,Alcohol consumption ,IgA ,Follow-Up Studies ,Glomerular Filtration Rate - Abstract
Purpose: To investigate the potential association between lifestyles, including cigarette smoking, alcohol consumption, and physical exercise at the time of biopsy and the risk for developing end-stage renal failure (ESRF) among IgA nephropathy (IgAN) patients within 10 years. Methods: A case–control study was carried out. Seventy-seven ESRF patients with the primary cause of IgAN were enrolled as cases. Seventy-seven IgAN patients who had not progressed to ESRF after being diagnosed for over 10 years served as controls. Smoking, alcohol consumption and physical exercise related data and baseline clinical features were collected from their medical records and confirmed by phone calls. Results: The case group had higher proportions of males, smokers, drinkers, and physical inactivity individuals than the controls had. Alcohol drinking history (/1 year, OR 1.32, p
- Published
- 2019
8. Determination and application of the solubility product of metal xanthate in mineral flotation and heavy metal removal in wastewater treatment
- Author
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Qi Shen, Pei-Pei Huang, Liuming Wu, Zhong-Xi Sun, and Yunhui Zhang
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chemistry.chemical_classification ,Mechanical Engineering ,Metal ions in aqueous solution ,Inorganic chemistry ,02 engineering and technology ,General Chemistry ,Solubility equilibrium ,021001 nanoscience & nanotechnology ,Geotechnical Engineering and Engineering Geology ,Chemical reaction ,020501 mining & metallurgy ,Metal ,chemistry.chemical_compound ,0205 materials engineering ,chemistry ,Control and Systems Engineering ,Ionic strength ,visual_art ,visual_art.visual_art_medium ,Xanthate ,Solubility ,0210 nano-technology ,Alkyl - Abstract
The reactions of ethyl and butyl xanthates with Pb2+, Cd2+ and Zn2+ were investigated to determine the solubility products of metal xanthates using UV/Visible spectroscopic method and software WinSGW and MEDUSA. The effects of solution pH, chemical reactions and ionic strength on the determination of solubility products of metal xanthates were investigated. For a given metal, the solubility product of metal xanthate was found to decrease with the increase of the carbon chain length of the alkyl group. The determined solubility products of metal xanthates were in the order of ZnX2 > CdX2 > PbX2 and M(EX)2 > M(BX)2. The accurate Ksp constant allowed more accurate calculation of the minimal concentration of xanthate ions for treating heavy metal-containing waste water to selectively separate metal ions, avoiding the potential presence of toxic xanthates in the treated water.
- Published
- 2018
9. Aquaporin 11 rs2276415 variant and progression of chronic kidney disease
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Si Liu, Fu-Xiang Zhu, Pei-Pei Huang, Xiao Wu, and Bin Han
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Male ,Oncology ,Nephrology ,China ,medicine.medical_specialty ,Genotype ,Population ,030232 urology & nephrology ,Comorbidity ,Type 2 diabetes ,030204 cardiovascular system & hematology ,Aquaporins ,Polymorphism, Single Nucleotide ,Disease-Free Survival ,Diabetic nephropathy ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Renal Dialysis ,Risk Factors ,Internal medicine ,Humans ,Medicine ,Diabetic Nephropathies ,Prospective Studies ,Renal Insufficiency, Chronic ,education ,Prospective cohort study ,Aged ,Transplantation ,Creatinine ,education.field_of_study ,business.industry ,Middle Aged ,medicine.disease ,Diabetes Mellitus, Type 2 ,chemistry ,Disease Progression ,Female ,business ,Kidney disease - Abstract
BACKGROUND The Aquaporin 11 (AQP11) rs2276415 variant has been implicated in kidney disease in Type 2 diabetes. Association of the AQP11 variant with chronic kidney disease (CKD) beyond diabetic nephropathy is unknown, with no studies reported in the Chinese population. We explored the risk of CKD progression associated with the AQP11 rs2276415 variant in a population-based study in China. METHODS We conducted a prospective cohort study of 620 participants with CKD (Stages 2-5 and who were not receiving dialysis) at the Nephrology Center of First Affiliated Hospital of Jiaxing University between July 2011 and December 2014 and followed up for 3 years. Incident CKD progression, defined as an increase in creatinine levels of at least 0.4 mg/dL (35 µmol/L) above baseline or maintenance dialysis initiation or transplantation, was examined by AQP11 genotypes. RESULTS During the follow-up period, CKD progression developed in 170 individuals. Cumulative events-free survival was significantly dependent on AQP11 genotypes with an apparent gene-dose effect (log-rank P
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- 2018
10. The formation of an ordered microporous aluminum-based material mediated by phthalic acid
- Author
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Wei Zhang, Li-Jun Wan, Lin-Lin Hu, Jianhua Cai, An-Min Cao, and Pei-Pei Huang
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Precipitation (chemistry) ,Chemistry ,Inorganic chemistry ,Metals and Alloys ,chemistry.chemical_element ,02 engineering and technology ,General Chemistry ,Microporous material ,010402 general chemistry ,021001 nanoscience & nanotechnology ,complex mixtures ,01 natural sciences ,Catalysis ,0104 chemical sciences ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,Phthalic acid ,chemistry.chemical_compound ,Aluminium ,Materials Chemistry ,Ceramics and Composites ,Water treatment ,0210 nano-technology ,Fluoride - Abstract
By using phthalic acid as a soft template, we showed that it was possible to prepare a microporous aluminum-based material when the precipitation of Al(3+) was properly controlled. We also identified that this microporous aluminum-based material could be promising for the removal of fluoride ions in water treatment.
- Published
- 2016
11. Evaluation of gastric lavage effi ciency and utility using a rapid quantitative method in a swine paraquat poisoning model.
- Author
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Yun-fei Jiang, Jian Kang, Pei-pei Huang, Jia-xi Yao, Zhong-he Wang, Lei Jiang, Jun Wang, Li Qiao, Bao-li Zhu, Hao Sun, and Jin-song Zhang
- Subjects
GASTRIC lavage ,QUANTITATIVE research ,GASTRIC juice ,SWINE ,SODIUM dithionite - Abstract
BACKGROUND: Gastric lavage (GL) is one of the most critical early therapies for acute paraquat (PQ) poisoning; however, details of the treatment protocol remain to be established. METHODS: A rapid quantitative method involving sodium dithionite testing was developed. It was validated for the determination of the PQ concentrations in gastric juice and eluate samples from a swine acute PQ poisoning model with early or delay GL, or without. The vital signs, laboratory testing, and PQ plasma concentrations were collected for therapeutic effect evaluation. RESULTS: The reaction conditions of the test were optimized for two types of samples. Early GL at one hour (H1) could improve the signs and symptoms after acute PQ poisoning at 24 hours (H24). In contrast, GL at 6 hours (H6) could only partially relieve the vital signs. The H1 GL group effectively reduced the peak of the plasma PQ concentration. In addition, the PQ concentrations in the plasma and the gastric juice were signifi cantly decreased in both the GL groups as compared to the untreated group at H24. Moreover, there was no signifi cant difference in the washing effi ciencies calculated from the total eluates between the two GL groups. However, the washing effi ciency of the fi rst 10 L eluate is superior to that of the additional 10 L eluate. CONCLUSION: GL only at early stage may it benefit PQ poisoning in an animal model. The currently used 20 L GL volume may need to be reduced in view of the low washing efficiency in the later 10 L eluate. The rapid quantitative method can be used for gastric juice sample and has a certain value for clinical GL practices. [ABSTRACT FROM AUTHOR]
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- 2020
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12. TOXIC EFFECTS OF MICROCYSTIS CELL EXTRACTS CONTAINING MICROCYSTIN-LR ON THE BLOOD OF MICE
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Xiao-Yu Li, Jun-Bo Liang, and Pei-Pei Huang
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chemistry.chemical_compound ,medicine.anatomical_structure ,Ecology ,biology ,Chemistry ,Microcystis ,Cell ,medicine ,Microcystin-LR ,Aquatic Science ,biology.organism_classification ,Water Science and Technology ,Microbiology - Published
- 2009
13. Embryonic and developmental toxicity of the ionic liquid 1-methyl-3-octylimidazolium bromide on goldfish
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San-Hu Wang, Jian-Ji Wang, Xiao-Yu Li, Pei-Pei Huang, Chun-Yu Wang, and Wei-Hong Zhang
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Embryo, Nonmammalian ,animal structures ,Health, Toxicology and Mutagenesis ,Developmental toxicity ,Embryonic Development ,Ionic Liquids ,Management, Monitoring, Policy and Law ,Biology ,Toxicology ,Cleavage (embryo) ,Lethal Dose 50 ,Andrology ,Goldfish ,Toxicity Tests ,Animals ,Analysis of Variance ,Molecular Structure ,Hatching ,Embryogenesis ,Imidazoles ,Embryo ,General Medicine ,Anatomy ,Acute toxicity ,Gastrulation ,embryonic structures ,Toxicity ,Water Pollutants, Chemical - Abstract
The embryonic developmental toxicity of the ionic liquid (IL) 1-methyl-3-octylimidazolium bromide ([C8mim]Br) on the goldfish Carassius auratus was evaluated in this study. First, the 72 h 50% lethal concentrations (72 h-LC50) for [C8mim]Br in goldfish embryos at the stages of cleavage, early gastrula, closure of blastopore, and heart beating were determined by preliminary acute toxicity tests. After that, fish embryos in different developmental stages (cleavage, early gastrula, closure of blastopore, and heart beating) were exposed to 10.4, 20.8, 41.6, and 104 mg/L of [C8mim]Br until their hatching stage. The results of the acute toxicity tests showed that 72 h-LC50 values at the early cleavage, early gastrula, closure of blastopore, and heart beating stages of development were 208.96, 187.1, 245.03, and 298.33 mg/L, respectively. In the subchronic tests, [C8mim]Br exposure prolonged the duration of embryo dechorionation and decreased the hatching rates of the treated embryos compared to control embryos. In addition, [C8mim]Br treatment also caused remarkable increases of embryonic malformation and mortality ratio in most treatment groups. Finally, we also found that the embryonic and developmental toxicity of [C8mim]Br on fish embryos was dose-response and developmental stage-specific. These results indicate that [C8mim]Br has toxic effects on the early embryonic development of goldfish, and the risk to aquatic ecosystem by ILs leaking into the water body must be evaluated in the future. © 2009 Wiley Periodicals, Inc. Environ Toxicol, 2010.
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- 2009
14. Influence of simvastatin on dopaminergic neurons of lipopolysaccharide-induced rat model of Parkinson's disease
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Bei-Sha Tang, Tian Zhang, Xiaowu Chen, Pei-Pei Huang, Xue-Bin Cao, Zhibin Chen, and Tan Wang
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medicine.medical_specialty ,Simvastatin ,Parkinson's disease ,Lipopolysaccharide ,Disease ,Neuroprotection ,chemistry.chemical_compound ,astrocyte ,Tumor necrosis factor–alpha ,Internal medicine ,polycyclic compounds ,Medicine ,Medicine(all) ,business.industry ,Dopaminergic ,nutritional and metabolic diseases ,General Medicine ,medicine.disease ,Endocrinology ,medicine.anatomical_structure ,chemistry ,nervous system ,lipids (amino acids, peptides, and proteins) ,Tumor necrosis factor alpha ,business ,medicine.drug ,Astrocyte - Abstract
ObjectiveTo investigate the neuroprotective effects of simvastatin on lipopolysaccharide (LPS)–induced rat model of Parkinson's disease (PD) and the mechanisms involved.MethodsHemiparkinsonian rat models were induced by stereotaxieal injection of LPS in the right substantia nigra compacta. After 2 weeks of simvastatin treatment, rotational behavior test was performed after the intraperitoneal injection of apomorphine. Expression of tyroxine hydroxylase (TH) and glial fibrillary acidic protein were analyzed through immunohistochemical staining of substantia nigra and striatum, and the level of TNF– α was evaluated using enzyme–linked immunosorbent assay.ResultsComparing with untreated group, behavioral symptoms of the rats were significantly less in the rats that received simvastatin treatment. The TH positive cell count in substantia nigra and striatum were significantly increased (P
- Published
- 2014
15. Effects of simvastatin on the expression of inducible nitric oxide synthase and brain-derived neurotrophic factor in a lipopolysaccharide-induced rat model of Parkinson disease
- Author
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Tan, Wang, primary, Xue-bin, Cao, additional, Tian, Zhang, additional, Xiao-wu, Chen, additional, Pei-pei, Huang, additional, Zhi-bin, Chen, additional, and Bei-sha, Tang, additional
- Published
- 2015
- Full Text
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16. Renal sympathetic denervation attenuates hypertension and vascular remodeling in renovascular hypertensive rats.
- Author
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Peng Li, Pei-Pei Huang, Yun Yang, Chi Liu, Yan Lu, Fang Wang, Wei Sun, and Xiang-Qing Kong
- Subjects
VASCULAR remodeling ,KIDNEY failure ,ANIMAL models in research - Abstract
Sympathetic activity is enhanced in patients with essential or secondary hypertension, as well as in various hypertensive animal models. Therapeutic targeting of sympathetic activation is considered an effective antihypertensive strategy. We hypothesized that renal sympathetic denervation (RSD) attenuates hypertension and improves vascular remodeling and renal disease in the 2-kidney, 1-clip (2K1C) rat model. Rats underwent 2K1C modeling or sham surgery; then rats underwent RSD or sham surgery 4 wk later, thus resulting in four groups (normotensive-sham, normotensive- RSD, 2K1C-sham, and 2K1C-RSD). Norepinephrine was measured by ELISA. Echocardiography was used to assess heart function. Fibrosis and apoptosis were assessed by Masson and TUNEL staining. Changes in mean arterial blood pressure in response to hexamethonium and plasma norepinephrine levels were used to evaluate basal sympathetic nerve activity. The 2K1C modeling success rate was 86.8%. RSD reversed the elevated systolic blood pressure induced by 2K1C, but had no effect on body weight. Compared with rats in the 2K1C-sham group, rats in the 2K1C-RSD group showed lower left ventricular mass/body weight ratio, interventricular septal thickness in diastole, left ventricular end-systolic diameter, and left ventricular posterior wall thickness in systole, whereas fractional shortening and ejection fraction were higher. Right kidney apoptosis and left kidney hypertrophy were not changed by RSD. Arterial fibrosis was lower in animals in the 2K1C-RSD group compared with those in the 2K1Csham group. RSD reduced plasma norepinephrine and basal sympathetic activity in rats in the 2K1C-RSD group compared with rats in the 2K1C-sham group. These results suggest a possible clinical efficacy of RSD for renovascular hypertension. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
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17. Effects of simvastatin on the expression of inducible nitric oxide synthase and brain-derived neurotrophic factor in a lipopolysaccharide-induced rat model of Parkinson disease.
- Author
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Tan, Wang, Xue-bin, Cao, Tian, Zhang, Xiao-wu, Chen, Pei-pei, Huang, Zhi-bin, Chen, and Bei-sha, Tang
- Subjects
NITRIC-oxide synthases ,SIMVASTATIN ,BRAIN-derived neurotrophic factor ,LIPOPOLYSACCHARIDES ,PARKINSON'S disease treatment ,LABORATORY rats ,THERAPEUTICS - Abstract
Objective: To investigate the effects of simvastatin on the expression of inducible nitric oxide synthase (iNOS) and brain-derived neurotrophic factor (BDNF) in the substantia nigra in a lipopolysaccharide (LPS)-induced rat model of Parkinson disease (PD), and to study the mechanisms underlying the neuroprotective effects of simvastatin in PD.Methods: The LPS-PD model was established by injection of LPS (5 mg/mL, 2.0 μL) into the right substantia nigra compacta (SNC). Rats in the sham-operated group received saline. The simvastatin treatment group was intraperitoneally administered simvastatin (5 mg/kg, 2.0 μL) at 1 h before, and daily for 14 days after surgery, while the sham-operated and LPS-model groups received saline. Iba-1-positive cells and tyrosine hydroxylase (TH), as well as iNOS and BDNF in the SNC were detected by immunohistochemistry and Western blotting, respectively. The effect of simvastatin in the PD model was also examined in behavioral tests.Results: The LPS-model group exhibited typical animal PD behaviors. Compared with the control group, the LPS-model group exhibited a decreased number of DA neurons (p< 0.01) in the SNC, as well as increases in the Iba-1-positive cell number and iNOS expression (p< 0.05), while BDNF expression was downregulated (p< 0.01). These effects were inhibited by simvastatin treatment (p< 0.05).Conclusion: Simvastatin mediates a protective effect on dopaminergic neurons in the SNC in the LPS-PD model, possibly by promoting neuronal repair and regeneration, and by inhibiting oxidative stress, thus improving substantia nigra function. [ABSTRACT FROM PUBLISHER]
- Published
- 2016
- Full Text
- View/download PDF
18. C60 fullerenol as an active and stable catalyst for the synthesis of cyclic carbonates from CO2 and epoxides.
- Author
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Yong-Bin Sun, Chang-Yan Cao, Shu-Liang Yang, Pei-Pei Huang, Chun-Ru Wang, and Wei-Guo Song
- Subjects
FULLERENES ,CATALYSTS ,CHEMICAL synthesis ,RING formation (Chemistry) ,CARBONATES ,CARBON dioxide ,EPOXY compounds - Abstract
C
60 fullerenol was found to be a highly active, selective and stable catalyst for cycloaddition between CO2 and epoxides to produce various cyclic carbonates with excellent yields (89-99%). A solid/ liquid interfacial hydrogen-bond assisted mechanism was proposed to account for its high efficiency. [ABSTRACT FROM AUTHOR]- Published
- 2014
- Full Text
- View/download PDF
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