Search

Your search keyword '"Pei-Gang Yang"' showing total 5 results
Start Over Author "Pei-Gang Yang"
5 results on '"Pei-Gang Yang"'

1. Clinical implications of micro lymph node metastasis for patients with gastric cancer

Author

Yuan Tian, Yue Pang, Pei-Gang Yang, Hong-Hai Guo, Yang Liu, Ze Zhang, Ping-An Ding, Tao Zheng, Yong Li, Li-Qiao Fan, Zhi-Dong Zhang, Dong Wang, Xue-Feng Zhao, Bi-Bo Tan, Yu Liu, and Qun Zhao

Subjects
Gastric carcinoma, Gastrectomy, Micro lymph node metastasis, Lymphadenectomy, Prognosis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Lymph node size is considered as a criterion for possible lymph node metastasis in imageology. Micro lymph nodes are easily overlooked by surgeons and pathologists. This study investigated the influencing factors and prognosis of micro lymph node metastasis in gastric cancer. Methods 191 eligible gastric cancer patients who underwent D2 lymphadenectomy from June 2016 to June 2017 in the Third Surgery Department at the Fourth Hospital of Hebei Medical University were retrospectively analyzed. Specimens were resected en bloc and the postoperative retrieval of micro lymph nodes was carried out by the operating surgeon for each lymph node station. Micro lymph nodes were submitted for pathological examination separately. According to the results of pathological results, patients were divided into the “micro-LNM (micro lymph node metastasis)” group (N = 85) and the “non micro-LNM” group (N = 106). Results The total number of lymph nodes retrieved was 10,954, of which 2998 (27.37%) were micro lymph nodes. A total of 85 (44.50%) gastric cancer patients had been proven to have micro lymph node metastasis. The mean number of micro lymph nodes retrieved was 15.7. The rate of micro lymph node metastasis was 8.1% (242/2998). Undifferentiated carcinoma (90.6% vs. 56.6%, P = 0.034) and more advanced Pathological N category (P

Published
2023
Full Text
View/download PDF

2. HIF-1α Induces Multidrug Resistance in Gastric Cancer Cells by Inducing MiR-27a.

Author

Qun Zhao, Yong Li, Bi-Bo Tan, Li-Qiao Fan, Pei-Gang Yang, and Yuan Tian

Subjects
Medicine, Science
Abstract

This study aimed to determine the correlation between HIF-1α and miR-27a expression and to evaluate the effect of inhibition of HIF-1α expression on miR-27a expression and drug resistance in gastric cancer (GC). In the present study, real time-PCR and Western blot were performed to detect the expression of HIF-1α in GC tissues and cell lines. Then, OCUM-2MD3/L-OHP cells were transfected with HIF-1α-siRNA, a miR-27a mimic or pcDNA-HIF-1α, and cell survival was determined via the MTT assay. The expression of HIF-1α, miR-27a, and MDR-related genes was measured via real time-PCR and Western blot. ChIP and dual luciferase activity assays were performed to assess the transcriptional regulation of HIF-1α and miR-27a. The results revealed that transfection with HIF-1α-siRNA markedly decreased the levels of miR-27a, resulting in dramatically enhanced inhibition of the proliferation rate of OCUM-2MD3/L-OHP cells. Compared to non-transfected cells, the survival rate was significantly reduced in the cells transfected with HIF-1α-siRNA after treatment with L-OHP. The cell survival rate was significantly increased in OCUM-2MD3/L-OHP cells transfected with the miR-27a mimic, whereas HIF-1α overexpression did not result in any clear change in cell survival. The results of the dual luciferase activity assay demonstrated that HIF-1α enhances the transcriptional activity of the miR27a promoter in cells transfected with a reporter plasmid containing the upstream promoter region of miR27a together with pcDNA-HIF-1α. ChIP analysis suggested that HIF-1α directly binds to the promoter region of miR27a. Inhibition of HIF-1α or miR27a expression decreased MDR1/P-gp, LRP, and Bcl-2 expression in OCUM-2MD3/L-OHP cells. Thus, we found that HIF-1α is closely associated with MDR in GC and that HIF-1α may suppress MDR1/P-gp, LRP and Bcl-2 expression by inhibiting miR-27a expression.

Published
2015
Full Text
View/download PDF

3. Efficient Surface Integral Equation Using Travelling-Standing-Wave Vector Basis Function for Complex EM Scattering Problems

Author

Zai Ping Nie, Pei Gang Yang, Shi Quan He, and Tao Qing

Subjects
Moment (mathematics), Standing wave, Surface (mathematics), Series (mathematics), Scattering, Mathematical analysis, Basis function, General Medicine, Function (mathematics), Perfect conductor, Mathematics
Abstract

A new set of travelling-standing-wave (TSW) basis functions are proposed for curved triangular patch in this paper. This kind of bases is not only able to describe the standing component of induced surface current but also able to simulate the phase variation of induced current accurately. The authors used these basis functions to discrete surface integral equation (SIE) with a series of coarse meshes (even larger than 2λ) to calculate the electromagnetic (EM) scattering from the perfect electric conductor (PEC) targets with method of moment (MoM). Numerical experiments indicate that the MoM-TSW scheme even has more advantages than the MLFMA-CRWG scheme in the aspects of computational efficiency and memory storage.

Published
2013
Full Text
View/download PDF

4. [Effects of XELOX regimen as neoadjuvant chemotherapy on radical resection rate and prognosis in patients with advanced gastric cancer]

Author

Qun, Zhao, Yong, Li, Bi-bo, Tan, Yuan, Tian, Zhi-kai, Jiao, Xue-feng, Zhao, Zhi-dong, Zhang, Dong, Wang, and Pei-gang, Yang

Subjects
Adult, Male, Oxaloacetates, Survivin, Apoptosis, Deoxycytidine, Disease-Free Survival, Inhibitor of Apoptosis Proteins, Proto-Oncogene Proteins p21(ras), Gastrectomy, Stomach Neoplasms, Proliferating Cell Nuclear Antigen, Antineoplastic Combined Chemotherapy Protocols, Humans, Capecitabine, Aged, Neoplasm Staging, Cell Cycle, Remission Induction, Middle Aged, Neoadjuvant Therapy, Survival Rate, Chemotherapy, Adjuvant, Female, Fluorouracil, Tumor Suppressor Protein p53, Follow-Up Studies
Abstract

The purpose of this study was to investigate the efficacy and mechanism of oxaliplatin in combination with capecitabine (XELOX) regimen as neoadjuvant chemotherapy in the treatment of patients with advanced gastric cancer.Eighty-five patients with advanced gastric cancer (stage IIB and IIIC) were randomly divided into two groups: neoadjuvant chemotherapy group (40 cases) and surgery alone group (45 cases). In the neoadjuvant chemotherapy group, patients received oral administration of Xeloda 1000 mg/m(2) twice a day on days 1-14 and intravenous infusion of oxaliplatin 130 mg/m(2) on day 1 (XELOX regimen). The regimen was repeated every 21 days. In the surgery alone group, patients directly received radical resection of gastric cancer. The R0 resection rate, overall survival and disease free survival (DFS) were observed in all cases. The cycles and apoptosis rate of the gastric cancer cells were detected by flow cytometry. The expression of proliferating cell nuclear antigen (PCNA), p21, p53 and survivin was detected by Western blot.In the neoadjuvant chemotherapy group, the total effective rate was 32.5% (13/40), and the tumor control rate was 90% (36/40), with few side effects. Compared with the surgery alone group, R0 resection rate was significantly higher in the neoadjuvant chemotherapy group (P0.05). The survival analysis indicated that both the overall survival and DFS were longer in the neoadjuvant chemotherapy group in comparison with those in the surgery alone group, but no significant differences were found (P0.05). In the neoadjuvant chemotherapy group, both the apoptosis rate and the ratio of cells in stage G0 and G1 were significantly higher than those in the surgery alone group (P0.05). The expression of PCNA and survivin was lower in the neoadjuvant chemotherapy group, while the expression of p21 and p53 was higher.XELOX regimen as neoadjuvant chemotherapy in the treatment of patients with advanced gastric cancer can effectively improve the R0 resection rate and prolong the survival time of the patients. Its mechanism is probably that the neoadjuvant chemotherapy can markedly enhance apoptosis in gastric cancer cells and inhibit their proliferation.

Published
2014

5. [Establishment of a new rabbit model of ischemic cerebral infarction by autologous clot embolism]

Author

Yan, Lin, Pei-Gang, Yang, Qi, Yu, Chun-Fang, Zhang, Hong, Zhu, Peng-Hui, Yang, and En-Qi, Liu

Subjects
Male, Disease Models, Animal, Random Allocation, Animals, Infarction, Middle Cerebral Artery, Cerebral Infarction, Rabbits
Abstract

To establish a convenient method for preparing rabbit models of ischemic cerebral infarction using autologous clot embolism.Ischemic cerebral infarction was induced in rabbits by embolizing the middle cerebral artery using autologous clot emboli. Clinical and histological observations were carried out to evaluate the validity of the animal model.Hemiplegia of different severities was observed in the rabbits after the operation. TTC and HE staining of the brain sections confirmed ischemic cerebral infarction 6 h after obstructing the middle cerebral artery with the autologous clot emboli.Embolizing the middle cerebral artery using the autologous emboli is convenient to induce focal ischemic cerebral infarction in rabbits. This model has practical value in the study on the mechanism of ischemic cerebrovascular disease and in developing new strategies for prevention and treatment of the relevant diseases in human.

Published
2009

Catalog

Books, media, physical & digital resources
See catalog results