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269 results on '"Pehlivan, Berrin"'

27. A Review on Brain Metastases Prognostic Scoring Systems

Author

Topkan, Erkan, primary, Kucuk, Ahmet, additional, Sezen, Duygu, additional, Senyurek, Sukran, additional, Aydemir, Eyub Yasar, additional, Durankus, Nulifer Kilic, additional, Bolukbasi, Yasemin, additional, Pehlivan, Berrin, additional, and Selek, Ugur, additional

Published
2021
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28. Low hemoglobin levels predict increased radiation‐induced trismus rates in nasopharyngeal cancer.

Author

Somay, Efsun, Yilmaz, Busra, Topkan, Erkan, Pehlivan, Berrin, and Selek, Uğur

Subjects
ANEMIA, CANCER relapse, RECEIVER operating characteristic curves, MULTIVARIATE analysis, CANCER chemotherapy, PRE-tests & post-tests, RADIATION carcinogenesis, CANCER patient psychology, TRISMUS, NASOPHARYNX tumors, SENSITIVITY & specificity (Statistics)
Abstract

Purpose: To investigate the predictive significance of hemoglobin (Hb) values in the incidence of radiation‐induced trismus (RIT) in locally advanced nasopharyngeal carcinoma (LA‐NPC) patients who received concurrent chemoradiotherapy (C‐CRT). Methods: Data of LA‐NPC patients were examined before and after C‐CRT and to confirm the presence of RIT, maximum mouth openings (MMO) were measured; RIT is defined as an MMO of ≤35 mm. All Hb values were derived from complete blood count tests obtained on the first day of C‐CRT. The receiver operating characteristic (ROC) curve analysis was used to scrutinize a possible connection between pre‐treatment Hb values and RIT status. Results: Two hundred and twenty three patients were included in the study and RIT was diagnosed in 46 (20.6%) patients. The Hb cutoff in ROC curve analysis that separated the patients into two groups was 12.05 g/dL [Area under the curve (AUC): 82.7%; sensitivity: 72.9%; and specificity: 71.3%]. RIT was significantly more prevalent in the Hb ≤ 12 g/dL group than in its counterpart (41.9% vs. 7.3%; p < 0.001). In multivariate analysis, Hb ≤ 12, anemia, pre‐C‐CRT MMO < 41.4 mm, and masticatory apparatus doseV58 Gy < 32% groups were found to be independently associated with significantly increased rates of RIT. Conclusion: Low pre‐C‐CRT Hb and anemia status are novel biological markers that independently predict higher RIT rates in LA‐NPC undergoing C‐CRT. [ABSTRACT FROM AUTHOR]

Published
2024
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31. Management of Brain Metastases with Preoperative Radiosurgery

Author

Topkan, Erkan, primary, Kucuk, Ahmet, additional, Senyurek, Sukran, additional, Sezen, Duygu, additional, Durankus, Nulifer Kilic, additional, Akdemir, Eyub Yasar, additional, Ikiz, Esma Didem, additional, Bolukbasi, Yasemin, additional, Pehlivan, Berrin, additional, and Selek, Ugur, additional

Published
2021
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40. Initial neutrophil‐to‐lymphocyte ratio predicts radiation‐induced trismus in parotid gland cancer.

Author

Somay, Efsun, Yilmaz, Busra, Topkan, Erkan, Kucuk, Ahmet, Pehlivan, Berrin, and Selek, Ugur

Subjects
BIOMARKERS, PREDICTIVE tests, TEMPOROMANDIBULAR joint, RETROSPECTIVE studies, ACQUISITION of data, TRISMUS, RISK assessment, NEUTROPHIL lymphocyte ratio, POSTOPERATIVE period, MEDICAL records, DESCRIPTIVE statistics, RECEIVER operating characteristic curves, SENSITIVITY & specificity (Statistics), PAROTID gland tumors, DISEASE risk factors
Abstract

Objective: To investigate the link between pretreatment neutrophil‐to‐lymphocyte ratio(NLR) and the incidence of radiation‐induced trismus(RIT) in parotid gland cancers(PGC) patients after postoperative radiotherapy(PORT). Method: Data of PGC patients who had oral examinations before and after PORT were reviewed retrospectively. We comprised patients who had maximum mouth opening (MMO) assessments before and after PORT and complete blood count test on the first day of PORT. MMO of ≤35 mm was considered as RIT. The receiver operating characteristic (ROC) curve analysis was used to search for an ideal NLR threshold value that might be linked to RIT rates. Results: Fifty‐one patients were included, with a RIT incidence of 15.7%. The NLR cutoff that showed a link with the prevalence of RIT in the ROC curve analysis was 2.7[Area under the curve (AUC):82.0%; sensitivity:87.5%; specificity:74.4%]. The patients were divided into groups based on this value:Group 1: NLR≤2.7 (N = 34) and;NLR >2.7 (N = 17). In comparative analysis, the incidence of RIT was found to be statistically higher in the NLR >2.7 than counterpart (35.2%vs.5.8%;rs:0.79; p <.001). Also, a mean temporomandibular joint dose ≥51.0Gy was linked to increased RIT rates (p <.001). Conclusion: This study showed that high pre‐PORT NLR levels were a robust and independent predictor of significantly elevated rates of RIT. [ABSTRACT FROM AUTHOR]

Published
2023
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41. Hemoglobin‐to‐platelet ratio in predicting the incidence of trismus after concurrent chemoradiotherapy.

Author

Somay, Efsun, Yilmaz, Busra, Topkan, Erkan, Kucuk, Ahmet, Haksoyler, Veysel, Pehlivan, Berrin, Selek, Ugur, and Araz, Kenan

Subjects
NASOPHARYNX cancer, HEMOGLOBINS, BLOOD platelets, MULTIVARIATE analysis, RETROSPECTIVE studies, TRISMUS, CHEMORADIOTHERAPY, RISK assessment, CANCER patients, RECEIVER operating characteristic curves
Abstract

Objective: The significance of pre‐hemoglobin‐to‐platelet ratio (HPR) in predicting the occurrence of radiation‐induced trismus (RIT) in locally advanced nasopharyngeal carcinoma patients (LA‐NPC) who received concurrent chemoradiotherapy (C‐CRT). Methods: The records of LA‐NPC patients with oral examination before and after C‐CRT were analyzed. Maximum mouth openings (MMO) were measured before and after C‐CRT to confirm RIT status, with an MMO of ≤35 mm defined as RIT. HPR values were calculated on the first day of C‐CRT. The relationship between the HPR values and RIT status was discovered using the receiver operating characteristic curve analysis. Results: A total of 43 patients RIT cases among 198 individuals were diagnosed. The optimal HPR cutoff that stratified the patients into two groups was 0.54. RIT incidence was found to be significantly higher in the HPR ≤0.54 group than its HPR >0.54 counterpart(p < 0.001). Univariately T3‐4 stage, mean masticator apparatus dose>57.2Gy, and pre‐C‐CRT MMO ≤40.7 mm were found as the other significant correlates of increased RIT rates(p < 0.05). All four variables seemed to be independently connected to greater RIT incidence in multivariate analysis (p < 0.05, for each). Conclusion: The risk of post‐C‐CRT RIT may be significantly increased when pre‐treatment HPR levels are low. [ABSTRACT FROM AUTHOR]

Published
2023
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42. Contributors

Author

Ahmed, Kamran, primary, Bagshaw, Hilary P., additional, Bang, Andrew, additional, Billfalk-Kelly, Astrid, additional, Boggs, Drexell, additional, Bolukbasi, Yasemin, additional, Brezovich, Ivan, additional, Buyyounouski, Mark K., additional, Caggiano, Allan, additional, Caudell, Jimmy, additional, Durankus, Nulifer Kilic, additional, Dziuk, Timothy W., additional, Gabel, Molly, additional, Gandhi, Saumil, additional, Gifford, Kent, additional, Goda, Jayant Sastri, additional, Gultekin, Melis, additional, Guzral, Dorothy, additional, Jaboin, Jerry, additional, Jacob, Rojymon, additional, Jalali, Rakesh, additional, Kim, Sungjune, additional, Leeman, Jonathan, additional, Leung, John, additional, Miller, Richard, additional, Murphy, Blair, additional, Oldham, Robert, additional, Pehlivan, Berrin, additional, Pippas, Andrew, additional, Popple, Richard, additional, Prionas, Nicolas D., additional, Reisman, David, additional, Rosenstein, Barry, additional, Schechter, Naomi, additional, Schultheiss, Timothy, additional, Selek, Ugur, additional, Sezen, Duygu, additional, Shen, Sui, additional, Smith, David, additional, Taunk, Neil, additional, Topkan, Erkan, additional, Trupp, Jefferson, additional, Tsang, Derek, additional, Williams, Matthew, additional, Yang, Jack, additional, Yavas, Guler, additional, Yazici, Gozde, additional, and Yildirim, Berna Akkus, additional

Published
2019
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