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231 results on '"Pedroso, Sofia"'

8. Surgical complications and technical failure of simultaneous pancreas‐kidney transplantation: A 22‐year experience from a single center

Author

Dias, Bruno Fraga, primary, Marques, Roberto Calças, additional, Cardoso, Catarina, additional, Faria, Vitória, additional, Domingues, Patrícia, additional, Ribeiro, Catarina, additional, Silvano, José, additional, Silva, Donzília, additional, Pedroso, Sofia, additional, Almeida, Manuela, additional, Malheiro, Jorge, additional, and Martins, La Salete, additional

Published
2024
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12. Longitudinal Trajectories of Estimated Glomerular Filtration Rate in a European Population of Living Kidney Donors.

Author

Almeida, Manuela, Reis Pereira, Pedro, Silvano, José, Ribeiro, Catarina, Pedroso, Sofia, Tafulo, Sandra, Martins, La Salete, Silva Ramos, Miguel, and Malheiro, Jorge

Subjects
GLOMERULAR filtration rate, KIDNEY physiology, KIDNEY transplantation, EPIDERMAL growth factor receptors, KIDNEY failure
Abstract

A living donor (LD) kidney transplant is the best treatment for kidney failure, but LDs safety is paramount. We sought to evaluate our LDs cohort's longitudinal changes in estimated glomerular filtration rate (eGFR). We retrospectively studied 320 LDs submitted to nephrectomy between 1998 and 2020. The primary outcome was the eGFR change until 15 years (y) post-donation. Subgroup analysis considered distinct donor characteristics and kidney function reduction rate (%KFRR) post-donation [-(eGFR6 months(M)-eGFRpre-donation)/eGFRpre-donation*100]. Donors had amean age of 47.3 ± 10.5 years, 71% female. Overall, LDs presented an average eGFR change 6 M onward of +0.35 mL/min/1.73 m²/year. The period with the highest increase was 6 M-2 Y, with a mean eGFR change of +0.85L/min/1.73 m²/year. Recovery plateaued at 10 years. Normal weight donors presented significantly better recovery of eGFR +0.59 mL/min/1.73 m²/year, compared to obese donors -0.18L/min/ 1.73 m²/year (p = 0.020). Noteworthy, these results only hold for the first 5 years. The subgroup with a lower KFRR (<26.2%) had a significantly higher decrease in eGFR overall of -0.21 mL/min/1.73 m²/year compared to the groups with higher KFRR (p < 0.001). These differences only hold for 6 M-2 Y. Moreover, an eGFR<50 mL/min/1.73 m² was a rare event, with ≤5%prevalence in the 2-15 Y span, correlating with eGFR pre-donation. Our data show that eGFR recovery is significant and may last until 10 years post-donation. However, some subgroups presented more ominous kidney function trajectories. [ABSTRACT FROM AUTHOR]

Published
2024
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17. International Kidney Paired Donation – The Experience of a Single Center

Author

Francisco, José, primary, Carvalho, Renata, additional, Freitas, Joana, additional, Coimbra, Miguel Trigo, additional, Vilela, Sara, additional, Almeida, Manuela, additional, Tafulo, Sandra, additional, Pereira, Rosário Caetano, additional, Bolotinha, Catarina, additional, Ivo, Margarida, additional, Sampaio, Susana, additional, Ribeiro, Catarina, additional, Silvano, José Luís, additional, Malheiro, Jorge, additional, Pedroso, Sofia, additional, Dias, Leonídio, additional, and Martins, La Salete, additional

Published
2023
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18. Doação Renal Cruzada Internacional – A Experiência de um Único Centro

Author

Francisco, José, primary, Carvalho, Renata, additional, Freitas, Joana, additional, Coimbra, Miguel Trigo, additional, Vilela, Sara, additional, Almeida, Manuela, additional, Tafulo, Sandra, additional, Pereira, Rosário Caetano, additional, Bolotinha, Catarina, additional, Ivo, Margarida, additional, Sampaio, Susana, additional, Ribeiro, Catarina, additional, Silvano, José Luís, additional, Malheiro, Jorge, additional, Pedroso, Sofia, additional, Dias, Leonídio, additional, and Martins, La Salete, additional

Published
2023
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21. Excess Mortality in Kidney and Kidney-Pancreas Transplant Recipients in the COVID-19 Pandemic in Portugal—A Cohort Study

Author

Coimbra, Miguel T., primary, Francisco, José A. T. S., additional, Freitas, Joana C., additional, Carvalho, Renata V., additional, Vilela, Sara R. B., additional, Ribeiro, Catarina I. C. D., additional, Silvano, José L. C. S. L., additional, Pedroso, Sofia, additional, Almeida, Manuela, additional, Martins, La Salete, additional, and Malheiro, Jorge, additional

Published
2023
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27. Antibody-Mediated Rejection in Kidney Transplantation: A Retrospective Study on the Impact of Donor-Specific Antibodies and on the Timing of Diagnosis

Author

Reis Pereira, Pedro, primary, Ribeiro, Bárbara, additional, Oliveira, João, additional, Santos, Sofia, additional, Pedroso, Sofia, additional, Tafulo, Sandra, additional, Almeida, Manuela, additional, Dias, Leonídio, additional, Martins, La Salete, additional, and Malheiro, Jorge, additional

Published
2022
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30. Older-to-Older Living Kidney Transplantation: A New Paradigm

Author

Figueiredo,Cátia Raquel, Sousa,Círia, Ventura,Sofia, Cruz,Gonçalo, Almeida,Manuela, Silvano,José, Malheiro,Jorge, Pedroso,Sofia, and Martins,La Salete

Subjects
Transplantation, Chronic Kidney, Aged Kidney Failure, Living Donors
Abstract

Older to older living kidney transplantation is an acceptable alternative to avoid dialysis, improve quality of life and maintain favorable long-term outcomes of patients with end-stage kidney disease. However, the management of these patients is complex and the acceptance of older donors and recipients to kidney transplantation remains controversial. The older recipients usually have several comorbidities that may complicate the postoperative course and increase the risk of end-stage kidney disease. We present a clinical case of living kidney transplantation between an older donor and recipient, both over 70 years old, who evolved to a stage 3 chronic kidney disease, without proteinuria, hypertension, or other complications, three years after transplantation. Our case reinforces favorable outcomes in older living transplantation, both for recipient and donor, as has been demonstrated in several published studies.

Published
2022

35. International Kidney Paired Donation - The Experience of a Single Center.

Author

Teixeira Francisco, José, Carvalho, Renata, Freitas, Joana, Trigo Coimbra, Miguel, Vilela, Sara, Almeida, Manuela, Tafulo, Sandra, Caetano Pereira, Rosário, Bolotinha, Catarina, Ivo, Margarida, Sampaio, Susana, Ribeiro, Catarina, Luís Silvano, José, Malheiro, Jorge, Pedroso, Sofia, Dias, Leonídio, and Salete Martins, La

Subjects
KIDNEY transplantation, KIDNEY exchange, BLOOD group incompatibility, CHRONIC kidney failure, PORTUGUESE people, KIDNEY diseases, RENAL tubular transport disorders, KIDNEY physiology, KIDNEYS
Abstract

Copyright of Brazilian Journal of Transplantation is the property of Brazilian Journal of Transplantation and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023
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38. ABO-incompatible living donor kidney transplantation in Portugal

Author

Catarina Ribeiro, Silva, Natália, Malheiro, Jorge, Almeida, Manuela, Pedroso, Sofia, La Salete Martins, Maria, Dias, Leonídio, Henriques, António Castro, and Cabrita, António

Subjects
Living Donor, Portugal, ABO incompatible, Kidney Transplantation
Abstract

Introduction: ABO incompatibility was considered a barrier to kidney transplant. However, the shortage of available organs for transplantation and the excellent long-term results further establish ABO-incompatible (ABOi) as a safe and effective therapeutic strategy. The aim of the present study was to evaluate the outcomes of ABOi transplantation in terms of graft survival and function, rejection episodes and infections complications. Methods: The authors present a single-center retrospective observational study in a unit with approximately 370 living donor kidney transplants registered. This study includes the analysis of 12 patients who underwent ABOi living donor kidney transplantation between November 2014 and July 2019. Desensitization protocol consisted of intravenous Rituximab 375mg/m2 single dose administration 2 weeks pretransplant. Tacrolimus and Mycophenolate Mofetil were started before transplantation one week and 48 hours respectively. Plasmapheresis was performed to remove anti-A or B antibodies until their titers were

Published
2020

43. Lower donated kidney volume is associated with increased risk of lower graft function and acute rejection at 1 year after living donor kidney—a retrospective study

Author

Silva, Filipa, primary, Malheiro, Jorge, additional, Pestana, Nicole, additional, Ribeiro, Catarina, additional, Nunes‐Carneiro, Diogo, additional, Mandanelo, Mariana, additional, Tavares, Joana, additional, Pedroso, Sofia, additional, Almeida, Manuela, additional, Silva‐Ramos, Miguel, additional, Dias, Leonídeo, additional, Martins, La Salete, additional, and Castro Henriques, António, additional

Published
2020
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45. 4-Nitrobenzyl 3,4-bis(acetyloxy)-2-(4-methoxyphenyl)pyrrolidine-1-carboxylate: crystal structure, Hirshfeld surface analysis and computational chemistry

Author

Dallasta Pedroso, Sofia, primary, Caracelli, Ignez, additional, Zukerman-Schpector, Julio, additional, Soto-Monsalve, Monica, additional, De Almeida Santos, Regina H., additional, Correia, Carlos Roque D., additional, Llanes Garcia, Ariel L., additional, Kwong, Huey Chong, additional, and Tiekink, Edward R. T., additional

Published
2020
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46. P1715CORRELATION OF DONATED KIDNEY MASS AND GRAFT FUNCTION IN RECIPIENTS OF LIVING DONOR KIDNEY TRANSPLANTATION

Author

Silva, Filipa, primary, Pestana, Nicole, primary, Ribeiro, Catarina Isabel, primary, Carneiro, Diogo, primary, Madanelo, Mariana, primary, Tavares, Joana, primary, Pedroso, Sofia, primary, Almeida, Manuela, primary, Malheiro, Jorge, primary, Dias, Leonídio, primary, Silva Ramos, Miguel, primary, Martins, La Salete, primary, and Henriques, António Castro, primary

Published
2020
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48. 1-Ethyl 2-methyl 3,4-bis(acetyloxy)pyrrolidine-1,2-dicarboxylate: crystal structure, Hirshfeld surface analysis and computational chemistry

Author

Dallasta Pedroso, Sofia, primary, Caracelli, Ignez, additional, Zukerman-Schpector, Julio, additional, Soto-Monsalve, Monica, additional, De Almeida Santos, Regina H., additional, Correia, Carlos Roque D., additional, Llanes Garcia, Ariel L., additional, Kwong, Huey Chong, additional, and Tiekink, Edward R. T., additional

Published
2020
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49. Severe passenger lymphocyte syndrome associated to Rh antibodies after donor living renal transplantation

Author

Antunes,Marika Bini, Malheiro,Jorge, Dias,Leonidio, Martins,La Salete, Pedroso,Sofia, Almeida,Manuela, Henriques,Antonio Castro, and Amil,Margarida

Subjects
Passenger lymphocyte, Rh antibody, transplantation
Abstract

The passenger lymphocyte syndrome may cause hemolytic anemia after bone marrow and solid organ transplantation when there is minor erythrocyte antigen incompatibility in the donor/recipient pair. Anemia is usually self-limiting, frequently related to ABO antibodies and rarely to Rh mismatches. We report a rare case of passenger B lymphocyte syndrome mediated by Rh antibodies occurring after a donor living renal transplantation and discuss its clinical severity at presentation, the therapeutic decisions and their outcome.

Published
2019

50. Refractory ascites and graft dysfunction in early renal transplantation

Author

Eusébio, Catarina Pereira, Correia, Sofia, Silva, Filipa, Almeida, Manuela, Pedroso, Sofia, Martins, La Salete, Diais, Leonídio, Queirós, José, Pessegueiro, Helena, Vizcaíno, Ramon, and Henriques, António Castro

Subjects
Transplante de Rim, Pharmaceutical Preparations, Ascite, Ascites, Fibrose, Kidney Transplantation, Fibrosis, Preparações Farmacêuticas
Abstract

The occurrence of ascites after Renal Transplant (RT) is infrequent, and may be a consequence of surgical or medical complications. Case report: 61 year-old, male, history of arterial hypertension, tongue carcinoma and alcoholic habits 12-20g/day. He had chronic kidney disease secondary to autosomal dominant polycystic kidney disease, without hepatic polycystic disease. He underwent cadaver donor RT in September 2017. He had delayed graft function by surgically corrected renal artery stenosis. He was admitted in January 2018 for ascites de novo, with no response to diuretics. HE had visible abdominal collateral circulation. Graft dysfunction, adequate tacrolinemia, Innocent urinary sediment, mild anemia, without thrombocytopenia. Serum albumin 4.0g / dL. Normal hepatic biochemistry. Peritoneal fluid with transudate characteristics and serum albumin gradient > 1.1. Ultrasound showed hepatomegaly, permeable vascular axes, without splenomegaly. Mycophenolate mofetil was suspended, with reduced remaining immunosuppression. He maintained refractory ascites: excluded infectious, metabolic, autoimmune and neoplastic etiologies. No nephrotic proteinuria and no heart failure. MRI: micronodules compatible with bile cysts. Upper Digestive Tract Endoscopy did not show gastroesophageal varicose veins. Normal abdominal lymphoscintigraphy. He underwent exploratory laparoscopy with liver biopsy: incomplete septal cirrhosis of probable vascular etiology some dilated bile ducts. He maintained progressive RT dysfunction and restarted hemodialysis. The proposed direct measurement of portal pressure was delayed by ascites resolution. There was further recovery of the graft function. Discussion: Incomplete septal cirrhosis is an uncommon cause of non-cirrhotic portal hypertension. Its definition is not well known, morphological and pathophysiological. We have not found published cases of post-RT ascites secondary to this pathology, described as possibly associated with drugs, immune alterations, infections, hypercoagulability and genetic predisposition. Resumo A ocorrência de ascite no pós-Transplante Renal (TR) é infrequente, podendo ser consequência de complicações cirúrgicas ou médicas. Caso clínico: 61 anos, masculino, antecedentes de hipertensão arterial, carcinoma da língua e hábitos alcoólicos 12-20g/dia. Doença renal crônica secundária à doença renal poliquística autossômica dominante, sem poliquistose hepática. Submetido a TR de doador cadáver em setembro de 2017. Atraso na função de enxerto por estenose da artéria renal, corrigida cirurgicamente. Internado em janeiro de 2018 por ascite de novo, sem resposta a diuréticos. Circulação colateral abdominal visível. Disfunção do enxerto, tacrolinemia adequada. Sedimento urinário inocente. Anemia ligeira, sem trombocitopenia. Albumina sérica 4,0g/dL. Bioquímica hepática normal. Líquido peritoneal com características de transudado e gradiente sero-ascítico de albumina > 1,1. Ecografia com hepatomegalia, eixos vasculares permeáveis, sem esplenomegalia. Suspendeu micofenolato mofetil, reduziu restante imunossupressão. Manteve ascite refratária: excluídas etiologias infecciosas, metabólicas, autoimunes e neoplásicas. Sem proteinúria nefrótica e sem insuficiência cardíaca. RM: micronódulos compatíveis com quistos biliares. EDA sem varizes gastroesofágicas. Linfocintigrafia abdominal normal. Submetido a laparoscopia exploradora com biópsia hepática: cirrose septal incompleta de provável etiologia vascular, alguns ductos biliares dilatados. Manteve disfunção progressiva do TR, reiniciou hemodiálise. Proposta medição direta da pressão portal, protelada por resolução da ascite. Recuperação posterior da função de enxerto. Discussão: A cirrose septal incompleta é uma causa incomum de hipertensão portal não cirrótica. A sua definição é morfológica e a fisiopatologia, pouco conhecida. Não encontramos publicados casos de ascite pós-TR secundária a esta patologia, descrita como possivelmente associada a fármacos, alterações imunitárias, infecções, hipercoagulabilidade e predisposição genética.

Published
2019

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