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8 results on '"Pedro Lima-Neto"'

1. Application of Nanostructured Carbon-Based Electrochemical (Bio)Sensors for Screening of Emerging Pharmaceutical Pollutants in Waters and Aquatic Species: A Review

Author

Álvaro Torrinha, Thiago M. B. F. Oliveira, Francisco W.P. Ribeiro, Adriana N. Correia, Pedro Lima-Neto, and Simone Morais

Subjects
sensors and biosensors, carbon nanomaterials, environment, aquatic fauna, waters, Chemistry, QD1-999
Abstract

Pharmaceuticals, as a contaminant of emergent concern, are being released uncontrollably into the environment potentially causing hazardous effects to aquatic ecosystems and consequently to human health. In the absence of well-established monitoring programs, one can only imagine the full extent of this problem and so there is an urgent need for the development of extremely sensitive, portable, and low-cost devices to perform analysis. Carbon-based nanomaterials are the most used nanostructures in (bio)sensors construction attributed to their facile and well-characterized production methods, commercial availability, reduced cost, high chemical stability, and low toxicity. However, most importantly, their relatively good conductivity enabling appropriate electron transfer rates—as well as their high surface area yielding attachment and extraordinary loading capacity for biomolecules—have been relevant and desirable features, justifying the key role that they have been playing, and will continue to play, in electrochemical (bio)sensor development. The present review outlines the contribution of carbon nanomaterials (carbon nanotubes, graphene, fullerene, carbon nanofibers, carbon black, carbon nanopowder, biochar nanoparticles, and graphite oxide), used alone or combined with other (nano)materials, to the field of environmental (bio)sensing, and more specifically, to pharmaceutical pollutants analysis in waters and aquatic species. The main trends of this field of research are also addressed.

Published
2020
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2. BIOSSENSOR ELETROQUÍMICO BASEADO NA ENZIMA TIROSINASE PARA A DETERMINAÇÃO DE FENOL EM EFLUENTES

Author

Dejane P. C. de Oliveira, Francisco W. P. Ribeiro, Helena Becker, Pedro Lima-Neto, and Adriana N. Correia

Subjects
biosensor, tyrosinase, phenol, wastewater, square-wave voltammetry, Chemistry, QD1-999
Abstract

AbstractThis work describes the development of a biosensor based on the tyrosinase enzyme (Tyr) for the determination of phenol (PHEN) in laboratory effluent samples derived from ammoniacal nitrogen analysis of the water samples from the Muquém dam in the city of Cariús, CE, using square-wave voltammetry (SWV). The electrode modification consisted of the immobilization of gold nanoparticles, multi-walled carbon nanotubes, cobalt phthalocyanine, and Tyr on a glassy carbon electrode. The electrolyte, pH, enzyme quantity, and voltammetric parameters were optimized to detect PHEN. The analytical curves presented a linear range from 4.97 × 10-6 mol L-1 to 6.10 × 10-5 mol L-1, and the detection limit (DL) and quantitation limit (QL) values were 4.81 × 10-6 mol L-1 and 4.97 × 10-6mol L-1, respectively. The repetition of measurements with the same biosensor and repetition for three other prepared biosensors exhibited a relative standard deviation (RSD) of 5.50 and 1.75%, respectively. The percentage recovery of PHEN in effluent samples varied from 86.40 to 105.04%. The stability of the biosensor was evaluated (at 21 days) with satisfactory results, showing 97.86% of the initial response. Moreover, the DL and recovery percentages agreed with the established values from CONAMA and ABNT, respectively. Thus, the electrode configuration developed seems a promising tool in the detection and quantification of PHEN in complex samples.

Published
2015
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4. Green lubricants production from Nile tilapia waste and prediction of physical properties through molecular dynamics simulations

Author

Denise Ramos Moreira, Elano Nery Ferreira, João Francisco Câmara Neto, Lucas Lima Bezerra, Norberto de Kássio Vieira Monteiro, Camila Peixoto Valle, Tathilene Bezerra Mota Gomes Arruda, Pedro Lima Neto, Jailson Silva Rodrigues, Francisco Eduardo Arruda Rodrigues, César Liberato Petzhold, Martin E. Maier, and Nágila Maria Pontes Silva Ricardo

Subjects
General Chemical Engineering, Organic Chemistry
Published
2022

6. Structure and graph-based virtual screening in pharmacodynamics, pharmacokinetics and antioxidant activity of the Castanol B against AKR1C2 prostate cancer target

Author

Matheus Nunes Rocha, Lucas Lima Bezerra, Leonardo Paes Silva, Francisco Wagner Queiroz Almeida-Neto, Márcia Machado Marinho, Hélcio Silva Santos, Pedro Lima Neto, and Emmanuel Silva Marinho

Abstract

The Chinese chestnut cultivation represents the advance of world trade, and the consumption provides several benefits for human health. Studies reported that a Chinese chestnut has several biological activities, such as anti-inflammatory, antioxidant, and antiproliferative. The polyphenol recently isolated from Chinese chestnut known as Castanol B was analyzed through of in silico approach using the ADMET simulations, quantum calculations, molecular docking, and molecular dynamics simulations. The ADMET results showed that the Castanol B conjugate base is more water-soluble, then conducting a theoretical pharmacokinetic model based on a great intestinal permeability and great metabolic stability, showing an antiproliferative activity with low toxic response to the host. The quantum calculations indicated that Castanol B acts by the HAT mechanism; besides, the anion carboxylate microspecies showed better thermodynamic favoring gas and water phases. The molecular docking results showed the highest potential interaction between the Aldo-keto reductase family 1 member C2 (AKR1C2) receptor with the compound analyzed, highlighted for the Castanol B and Castanol B conjugate base. Finally, the molecular dynamics results indicated that the Castanol B conjugate base showed high stability and the highest potential of interactions during the simulations. Therefore, this compound presented might potentially be used to treat prostate cancer.

Published
2022

7. TECHNICAL PROOF IN THE ADMINISTRATIVE INQUIRY ON ACCIDENTS AND FACTS OF NAVIGATION

Author

Antonio Eduardo Ramires Santoro, Pedro Lima Neto, and Rodrigo Grazinoli Garrido

Subjects
lcsh:K1-7720, evidência, lcsh:Law in general. Comparative and uniform law. Jurisprudence, perícia, direito marítimo
Abstract

It was sought through doctrinal, jurisprudential and empirical research, to determine the legal nature of the technical examination conducted during the Accident Survey and Facts of Navigation. In addition, it was identified who performs such examinations and if there would be influence of the professional formation for the effective use of these exams in the decisions of the Maritime Court. It is concluded that the technical exams are really a medium of expert evidence and not merely an informative element, and it should be necessary the performance of specialized professionals. However, this demand was not observed in the analyzed processes. Such deficiency may be reflected in a lack of technical-scientific evidence, preventing an effective resolution of the dispute, as was observed in some of the judgments analyzed.

Published
2018

8. A PROVA TÉCNICA NO INQUÉRITO ADMINISTRATIVO SOBRE ACIDENTES E FATOS DA NAVEGAÇÃO

Author

Pedro Lima Neto, Antonio Eduardo Ramires Santoro, and Rodrigo Grazinoli Garrido

Subjects
Accident (fallacy), Empirical research, Materials Science (miscellaneous), Applied psychology, Business and International Management, Element (criminal law), General Agricultural and Biological Sciences, Psychology, General Business, Management and Accounting, Industrial and Manufacturing Engineering
Abstract

It was sought through doctrinal, jurisprudential and empirical research, to determine the legal nature of the technical examination conducted during the Accident Survey and Facts of Navigation. In addition, it was identified who performs such examinations and if there would be influence of the professional formation for the effective use of these exams in the decisions of the Maritime Court. It is concluded that the technical exams are really a medium of expert evidence and not merely an informative element, and it should be necessary the performance of specialized professionals. However, this demand was not observed in the analyzed processes. Such deficiency may be reflected in a lack of technical-scientific evidence, preventing an effective resolution of the dispute, as was observed in some of the judgments analyzed.

Published
2018

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