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Your search keyword '"Pedro H. da S. Barata"' showing total 2 results
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2 results on '"Pedro H. da S. Barata"'

1. Chemoenzymatic Synthesis and Anti-Inflammatory Activity of Fatty Acid Amides Prepared from Bertholletia excelsa (Brazil Nut) Triglycerides

Author

Albenise Santana Alves Barros, Edilene O. Silva, Adan Galué-Parra, Helison de Oliveira Carvalho, José Carlos Tavares Carvalho, Pedro H. da S. Barata, Irlon M. Ferreira, Ícaro Rodrigues Sarquis, and Alex Bruno Lobato Rodrigues

Subjects
chemistry.chemical_classification, biology, Chemistry, medicine.drug_class, Fatty acid, Pseudomonas fluorescens, General Chemistry, Anandamide, biology.organism_classification, food.food, Anti-inflammatory, chemistry.chemical_compound, food, Edema, medicine, biology.protein, Bertholletia, Food science, medicine.symptom, Lipase, Brazil nut
Abstract

This study reports the synthesis of fatty acid amides (FAA), analogous to anandamide, prepared from Brazil nut oil (BNO), using Amano lipase from Pseudomonas fluorescens as a catalyst of direct aminolysis, with a good yield (95-68%). The anti-inflammatory effects of BNO and FAA were evaluated by the carrageenan-induced paw edema method. Analysis of the formation of edema showed that these FAA, at all dose used, significantly reduced the development of edema.

Published
2020

2. Direct and Solvent-Free Aminolysis of Triglyceride from Oenocarpus bataua (Patawa) Oil Catalyzed by Al2O3

Author

José Carlos Tavares Carvalho, Didier Bereau, Raquel R. Amaral, Inana F. Araújo, Pedro H. da S. Barata, Irlon M. Ferreira, Pedro H. F. de Araújo, and Jhone M. Curti

Subjects
chemistry.chemical_classification, biology, Triglyceride, 010405 organic chemistry, Chemistry, Fatty acid, General Chemistry, 010402 general chemistry, biology.organism_classification, Antimicrobial, Heterogeneous catalysis, 01 natural sciences, Catalysis, 0104 chemical sciences, Solvent, chemistry.chemical_compound, Aminolysis, Oenocarpus bataua, Organic chemistry
Abstract

The amidation of fatty acid is an important reaction for synthesis of fatty alkolamines with a variety of pharmacological activities. The objective of this paper was to demonstrate the aminolysis direct and solvent of the triglycerides from the patawa oil by heterogeneous catalysis. The results of the amidation direct free solvents were favorable using 5% Al2O3 as catalyst, with a conversion of 94% at 24 h of reaction. After spectroscopic characterization, we decided explore the antimicrobial tests of the fatty amides (FAA) against the Staphylococcus aureus strain (ATCC 33591), showing a MIC activity of 1.9612 mg/mL and the fatty ethyl esters (FAEE) a 3.4125 mg/mL MIC. Therefore, the synthesis direct free solvents of FAA by Al2O3 from patawa oil was viable and innovative.

Published
2018

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