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Definitely the statement that the different axes substantially influence not only bidirectional communication, but health and disease, is evident. In the near future there will be both axes as organs and almost all will be related to the activity of the Intestinal Microbiota. Generating a personal diet is a good recipe. Prescribing pre, pro or symbiotics is appropriate. Producing modulation of the Intestinal Microbiota, together with the two premises indicated, is a promising future for the correction of many conditions. Keywords:Intestinal microbiome; Intestinal microbiota; Axis microbiota; Intestinal microbiota Transplantation (IMT)

In the history of humanity, the first TMF was made in the 4th century BC. C. During the Dong-jin Chinese dynasty, the physician Ge Hong described the oral administration of a suspension prepared from human feces in patients with food poisoning or severe diarrhea with good results. In the sixteenth century, during the Ming Dynasty, Li Shi Zhen described in the book of traditional Chinese medicine Ben Cao Gang Mu (Compendium of Materia Medica), the prescription of faecal suspensions (fermented or fresh) and dried faeces for the treatment of diseases abdominals that occur with diarrhea, fever, pain, vomiting and constipation. For aesthetic reasons, doctors labeled these preparations as "yellow soup." The Italian doctor Fabricius Aquapendente, in the seventeenth century, referred to IMT as transfaunation and used it in veterinary medicine. The TMI was used by German soldiers to treat bacterial dysentery during World War II. In the year 1958, Eisman et al. They publish the first article in which four patients with pseudo-membranous colitis were treated with TMF (1). The IMT has generated a change in the perspective of the treatment of multiple diseases. Mark Smith says "We have more than 130 samples ready to use", who after graduating in Microbiology at the Massachusetts Institute of Technology has set up OpenBiome, where faeces, mixed with glycerol so they do not spoil, are stored cold (2). Our group was the first to carry out the TMI in Mexico, in patients not carrying Clostridium difficile, as reported in the Journal Surgery and Surgeons. Vol.86: No. 3. 2018. Zamudio TA, Bermúdez RH, Lezama GH, Guevara OM, Solares EI, Sosa LF. BREAKING PARADIGMS. INTESTINAL MICROBIOTE TRANSPLANT. PRELIMINARY REPORT. http://dx.doi.org/10.1016/j.circir.2016.11.017 Keywords:Fecal microbiota transplantation (FMT); Intestinal microbiota (IM); Intestinal microbiota transplantation (IMT). Microbiota microbioma