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1,003 results on '"Pedrazzoli, Paolo"'

1. Long-term responders to nivolumab in previously treated advanced renal cell carcinoma: a sub-analysis of meet-URO15 study

Author

Messina, Carlo, Catalano, Martina, Roviello, Giandomenico, Gandini, Annalice, Maruzzo, Marco, De Giorgi, Ugo, Pedrazzoli, Paolo, Sbrana, Andrea, Zucal, Paolo Andrea, Masini, Cristina, Naglieri, Emanuele, Procopio, Giuseppe, Milella, Michele, Catalano, Fabio, Fratino, Lucia, Pipitone, Stefania, Ricotta, Riccardo, Panni, Stefano, Mollica, Veronica, Soraru, Mariella, Prati, Veronica, Atzori, Francesco, Di Napoli, Marilena, Messina, Marco, Morelli, Franco, Prati, Giuseppe, Nole, Franco, Malgeri, Andrea, Tudini, Marianna, Vignani, Francesca, Cavo, Alessia, Signori, Alessio, Banna, Giuseppe Luigi, Rescigno, Pasquale, Buti, Sebastiano, Rebuzzi, Sara Elena, and Fornarini, Giuseppe

Published
2024
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3. Integrating Industry 5.0 Competencies: A Learning Factory Based Framework

Author

Agbomemewa, Lorenzo, Daniele, Fabio, Foletti, Michele, Confalonieri, Matteo, Pedrazzoli, Paolo, Rannenberg, Kai, Editor-in-Chief, Soares Barbosa, Luís, Editorial Board Member, Carette, Jacques, Editorial Board Member, Tatnall, Arthur, Editorial Board Member, Neuhold, Erich J., Editorial Board Member, Stiller, Burkhard, Editorial Board Member, Stettner, Lukasz, Editorial Board Member, Pries-Heje, Jan, Editorial Board Member, M. Davison, Robert, Editorial Board Member, Rettberg, Achim, Editorial Board Member, Furnell, Steven, Editorial Board Member, Mercier-Laurent, Eunika, Editorial Board Member, Winckler, Marco, Editorial Board Member, Malaka, Rainer, Editorial Board Member, Thürer, Matthias, editor, Riedel, Ralph, editor, von Cieminski, Gregor, editor, and Romero, David, editor

Published
2024
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4. Impact of Collaborative Robots on Human Trust, Anxiety, and Workload: Experiment Findings

Author

Montini, Elias, Ploner, Giovanni, Matteri, Davide, Cutrona, Vincenzo, Rocco, Paolo, Bettoni, Andrea, Pedrazzoli, Paolo, Rannenberg, Kai, Editor-in-Chief, Soares Barbosa, Luís, Editorial Board Member, Carette, Jacques, Editorial Board Member, Tatnall, Arthur, Editorial Board Member, Neuhold, Erich J., Editorial Board Member, Stiller, Burkhard, Editorial Board Member, Stettner, Lukasz, Editorial Board Member, Pries-Heje, Jan, Editorial Board Member, M. Davison, Robert, Editorial Board Member, Rettberg, Achim, Editorial Board Member, Furnell, Steven, Editorial Board Member, Mercier-Laurent, Eunika, Editorial Board Member, Winckler, Marco, Editorial Board Member, Malaka, Rainer, Editorial Board Member, Thürer, Matthias, editor, Riedel, Ralph, editor, von Cieminski, Gregor, editor, and Romero, David, editor

Published
2024
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5. Solid Tumours

Author

Ladenstein, Ruth, Pedrazzoli, Paolo, Rosti, Giovanni, Sureda, Anna, editor, Corbacioglu, Selim, editor, Greco, Raffaella, editor, Kröger, Nicolaus, editor, and Carreras, Enric, editor

Published
2024
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7. The European Society for Blood and Marrow Transplantation (EBMT) roadmap and perspectives to improve nutritional care in patients undergoing hematopoietic stem cell transplantation on behalf of the Cellular Therapy and Immunobiology Working Party (CTIWP) and the Nurses Group (NG) of the EBMT

Author

Casirati, Amanda, Salcedo, Isabel, Cereda, Emanuele, Chabannon, Christian, Ruggeri, Annalisa, Kuball, Jurgen, Clout, Ruth, Mooyaart, Jarl E., Kenyon, Michelle, Caccialanza, Riccardo, Pedrazzoli, Paolo, and Kisch, Annika M.

Published
2023
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8. Bioimpedance-derived body composition parameters predict mortality and dose-limiting toxicity: the multicenter ONCO-BIVA study

Author

Caccialanza, Riccardo, Cereda, Emanuele, Casirati, Amanda, Crotti, Silvia, Masi, Sara, Klersy, Catherine, Ferrari, Alessandra, Pedrazzoli, Paolo, Gavazzi, Cecilia, Vandoni, Giulia, Farina, Gabriella, La Verde, Nicla, Zagonel, Vittorina, Nardi, Maria Teresa, Baldan, Ilaria, Di Costanzo, Francesco, Mascheroni, Annalisa, Trestini, Ilaria, Valoriani, Filippo, Lucchin, Lucio, Aprile, Giuseppe, De Francesco, Antonella, Agnello, Elena, Giovanardi, Filippo, Cereda, E., Casirati, A., Klersy, C., Nardi, M., Vandoni, G., Agnello, E., Crotti, S., Masi, S., Ferrari, A., Pedrazzoli, P., and Caccialanza, R.

Published
2024
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11. Introducing Active Learning and Serious Game in Engineering Education: 'Experience from Lean Manufacturing Course'

Author

Gianpiero, Mattei, Pedrazzoli, Paolo, Landolfi, Giuseppe, Daniele, Fabio, Montini, Elias, Rannenberg, Kai, Editor-in-Chief, Soares Barbosa, Luís, Editorial Board Member, Goedicke, Michael, Editorial Board Member, Tatnall, Arthur, Editorial Board Member, Neuhold, Erich J., Editorial Board Member, Stiller, Burkhard, Editorial Board Member, Stettner, Lukasz, Editorial Board Member, Pries-Heje, Jan, Editorial Board Member, Kreps, David, Editorial Board Member, Rettberg, Achim, Editorial Board Member, Furnell, Steven, Editorial Board Member, Mercier-Laurent, Eunika, Editorial Board Member, Winckler, Marco, Editorial Board Member, Malaka, Rainer, Editorial Board Member, Alfnes, Erlend, editor, Romsdal, Anita, editor, Strandhagen, Jan Ola, editor, von Cieminski, Gregor, editor, and Romero, David, editor

Published
2023
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12. Previous immune checkpoint inhibitor therapy is associated with decreased COVID-19-related hospitalizations and complications in patients with cancer: Results of a propensity-matched analysis of the OnCovid registry

Author

Mostaghim, Anahita, Minkove, Samuel, Aguilar-Company, Juan, Ruiz-Camps, Isabel, Eremiev-Eremiev, Simeon, Dettorre, Gino M., Fox, Laura, Tondini, Carlo, Brunet, Joan, Carmona-García, MCarmen, Lambertini, Matteo, Bower, Mark, Newsom-Davis, Thomas, Sharkey, Rachel, Pria, Alessia Dalla, Rossi, Maura, Plaja, Andrea, Salazar, Ramon, Sureda, Anna, Prat, Aleix, Michalarea, Vasiliki, Van Hemelrijck, Mieke, Sita-Lumsden, Ailsa, Bertuzzi, Alexia, Rimassa, Lorenza, Rossi, Sabrina, Rizzo, Gianpiero, Pedrazzoli, Paolo, Lee, Alvin JX, Murphy, Cian, Belessiotis, Katherine, Diamantis, Nikolaos, Mukherjee, Uma, Pommeret, Fanny, Stoclin, Annabelle, Martinez-Vila, Clara, Bruna, Riccardo, Gaidano, Gianluca, D'Avanzo, Francesca, Gennari, Alessandra, Athale, Janhavi, Eichacker, Peter, Pinato, David J., Torabi-Parizi, Parizad, and Cortellini, Alessio

Published
2024
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14. Tissue fluidification promotes a cGAS–STING cytosolic DNA response in invasive breast cancer

Author

Frittoli, Emanuela, Palamidessi, Andrea, Iannelli, Fabio, Zanardi, Federica, Villa, Stefano, Barzaghi, Leonardo, Abdo, Hind, Cancila, Valeria, Beznoussenko, Galina V., Della Chiara, Giulia, Pagani, Massimiliano, Malinverno, Chiara, Bhattacharya, Dipanjan, Pisati, Federica, Yu, Weimiao, Galimberti, Viviana, Bonizzi, Giuseppina, Martini, Emanuele, Mironov, Alexander A., Gioia, Ubaldo, Ascione, Flora, Li, Qingsen, Havas, Kristina, Magni, Serena, Lavagnino, Zeno, Pennacchio, Fabrizio Andrea, Maiuri, Paolo, Caponi, Silvia, Mattarelli, Maurizio, Martino, Sabata, d’Adda di Fagagna, Fabrizio, Rossi, Chiara, Lucioni, Marco, Tancredi, Richard, Pedrazzoli, Paolo, Vecchione, Andrea, Petrini, Cristiano, Ferrari, Francesco, Lanzuolo, Chiara, Bertalot, Giovanni, Nader, Guilherme, Foiani, Marco, Piel, Matthieu, Cerbino, Roberto, Giavazzi, Fabio, Tripodo, Claudio, and Scita, Giorgio

Published
2023
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16. SARS-CoV-2 omicron (B.1.1.529)-related COVID-19 sequelae in vaccinated and unvaccinated patients with cancer: results from the OnCovid registry

Author

Evans, Joanne S, Swallow, Judith, Hanbury, Georgina, Chung, Chris, Patel, Meera, Dettorre, Gino, Belessiotis, Katherine, Saorise, Dolly, Jones, Eleanor, Apthorp, Eleanor, Moss, Charlotte, Russell, Beth, Townsend, Sarah, Jackson, Amanda, Loizidou, Angela, Piccart, Martine, Pommeret, Fanny, Colomba-Blameble, Emeline, Prat, Aleix, Cruz, Claudia A, Reyes, Roxana, Segui, Elia, Marco-Hernández, Javier, Viladot, Margarita, Harbeck, Nadia, Wuerstlein, Rachel, Henze, Franziska, Mahner, Sven, Felip, Eudald, Scotti, Lorenza, Marrari, Andrea, Grosso, Federica, Fusco, Vittorio, Delfanti, Sara, Rossi, Maura, Zambelli, Alberto, Tondini, Carlo, Chiudinelli, Lorenzo, Franchi, Michela, Libertini, Michela, Provenzano, Salvatore, Generali, Daniele, Grisanti, Salvatore, Baggi, Alice, Tovazzi, Valeria, Ficorella, Corrado, Porzio, Giampiero, Saponara, Maristella, Filetti, Marco, Tucci, Marco, Berardi, Rossana, Cantini, Luca, Paoloni, Francesco, Guida, Annalisa, Bracarda, Sergio, Iglesias, Maria, Sanchez de Torre, Ana, Tagliamento, Marco, Cortellini, Alessio, Tabernero, Josep, Mukherjee, Uma, Salazar, Ramon, Sureda, Anna, Maluquer, Clara, Ferrante, Daniela, Bower, Mark, Sharkey, Rachel, Mirallas, Oriol, Plaja, Andrea, Cucurull, Marc, Mesia, Ricard, Dalla Pria, Alessia, Newsom-Davis, Thomas, Van Hemelrijck, Mieke, Sita-Lumsden, Ailsa, Vincenzi, Bruno, Di Fazio, Giuseppina Rita, Tonini, Giuseppe, Pantano, Francesco, Bertuzzi, Alexia, Rossi, Sabrina, Brunet, Joan, Lambertini, Matteo, Pedrazzoli, Paolo, Biello, Federica, D'Avanzo, Francesca, Lee, Alvin J X, Shawe-Taylor, Marianne, Rogers, Lucy, Murphy, Cian, Cooper, Lee, Andaleeb, Ramis, Khalique, Saira, Bawany, Samira, Ahmed, Sarah, Carmona-García, M Carmen, Fort-Culillas, Roser, Liñan, Raquel, Zoratto, Federica, Rizzo, Gianpiero, Perachino, Marta, Doonga, Kris, Gaidano, Gianluca, Bruna, Riccardo, Patriarca, Andrea, Martinez-Vila, Clara, Pérez Criado, Ignacio, Giusti, Raffaele, Mazzoni, Francesca, Antonuzzo, Lorenzo, Santoro, Armando, Parisi, Alessandro, Queirolo, Paola, Aujayeb, Avinash, Rimassa, Lorenza, Diamantis, Nikolaos, Bertulli, Rossella, Fulgenzi, Claudia A M, D'Alessio, Antonio, Ruiz-Camps, Isabel, Saoudi-Gonzalez, Nadia, Garcia Illescas, David, Medina, Irene, Fox, Laura, Gennari, Alessandra, Aguilar-Company, Juan, and Pinato, David J

Published
2023
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19. Randomized trial of sucrosomial iron supplementation in patients with chemotherapy-related anemia treated with ESA

Author

Zuccarini, Andrea, Cicognini, Daniela, Tancredi, Richard, Ferrari, Alessandra, Rizzo, Gianpiero, Lasagna, Angioletta, Caccialanza, Riccardo, Cavanna, Luigi, Orlandi, Elena, Biasini, Claudia, Molinaro, Peppina, Garigliano, Danula, Costantino, Angela, Moroni, Mauro, Perrone, Lorenzo, Alessio, Niccolò Leandro, Rovati, Bianca, Ferretti, Virginia Valeria, Klersy, Catherine, and Pedrazzoli, Paolo

Published
2022
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20. Developments in Solid Tumours

Author

Pedrazzoli, Paolo, Haanen, John B. A. G., Kröger, Nicolaus, editor, Gribben, John, editor, Chabannon, Christian, editor, Yakoub-Agha, Ibrahim, editor, and Einsele, Hermann, editor

Published
2022
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21. Multicentric, observational, longitudinal study for the evaluation of nutritional management implications in newly diagnosed Italian cancer patients: the Italian Registry of Malnutrition in Oncology (IRMO)

Author

Paolo Pedrazzoli, Francesco De Lorenzo, Elisabetta Iannelli, Cristina Bosetti, Valentina Da Prat, Riccardo Caccialanza, Emanuele Cereda, Fortes Cristina, Alessandra Ferrari, Francesco Serra, Amanda Casirati, Sara Masi, Silvia Crotti, Lorenzo Perrone, Claudia Santucci, Caccialanza Riccardo, Cannizzaro Renato, Casalone Valentina, Cici Rosalisa, De Lorenzo Francesco, De Pergola Giovanni, Di Lauro Teresa, Gori Stefania, Ibrahim Toni, Longhi Alessandra, Mele Maria Cristina, Mele Roberto, Montemurro Filippo, Nardi Maria Teresa, Pedrazzoli Paolo, Pezzuolo Debora, Pinto Carmine, Pignata Sandro, Pozzo Carmelo, Sanchez Mete Lupe, Serra Patrizia, Sukkar Samir Guseppe, Tonello Marco, and Zagonel Vittorina

Subjects
Medicine
Abstract

Background Malnutrition is a frequent problem in oncology and is associated with reduced response to cancer treatments, increased drug-related toxicity, higher rates of clinical complications, reduced quality of life (QoL) and worse prognosis. Guidelines on clinical nutrition in oncology emphasise the usefulness of early assessment of nutritional status for a prompt identification of malnutrition and the implementation of effective interventions, but no real-world clinical data are available on the adequate management of nutritional support in patients with cancer in Italy.Methods and analysis This is an observational, longitudinal, multicentre registry of patients with a new diagnosis of cancer or metastatic disease, candidates for active treatment. They will be identified in at least 15 Italian oncological centres, members of the Alliance Against Cancer Working Group ‘Survivorship Care and Nutritional Support’. At least 1500 patients with cancer are expected to be enrolled each year. Detailed clinical and nutritional data will be collected by oncologists and clinical nutritionists during the visits foreseen in the clinical practice, through an ad hoc developed digital platform (e-Nutracare). The effects of malnutrition and nutritional support—at diagnosis and during follow-up—on overall survival and progression-free survival, as well as on patients’ symptoms and QoL, will be investigated.Ethics and dissemination The study protocol was approved by the Ethics Committee of the Fondazione IRCCS Policlinico San Matteo, Pavia, Italy and from the Ethics Committees of all other participating centres. An informed consent will be obtained from each patient enrolled in the study. Study findings will be disseminated through peer-reviewed journals, conferences and patients with cancer or professional associations. The registry will allow a better monitoring of the nutritional status of patients with cancer, promoting adequate and sustainable nutritional support, with the ultimate goal of improving the care and prognosis of these patients.

Published
2023
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22. Indications for haematopoietic cell transplantation for haematological diseases, solid tumours and immune disorders: current practice in Europe, 2022

Author

Snowden, John A., Sánchez-Ortega, Isabel, Corbacioglu, Selim, Basak, Grzegorz W., Chabannon, Christian, de la Camara, Rafael, Dolstra, Harry, Duarte, Rafael F., Glass, Bertram, Greco, Raffaella, Lankester, Arjan C., Mohty, Mohamad, Neven, Bénédicte, de Latour, Régis Peffault, Pedrazzoli, Paolo, Peric, Zinaida, Yakoub-Agha, Ibrahim, Sureda, Anna, and Kröger, Nicolaus

Published
2022
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24. Industrial Internet of Things and the Innovation Processes in Smart Manufacturing

Author

Gusmeroli, Sergio, primary, Lazaro, Oscar, additional, Pazin, Željko, additional, Decubber, Chris, additional, Pedrazzoli, Paolo, additional, Abeele, Didier Vanden, additional, Tucci-Piergiovanni, Sara, additional, Cassina, Jacopo, additional, Cerri, Daniele, additional, Terzi, Sergio, additional, Sola, June, additional, Arconada, Ignacio, additional, Fischer, Klaus, additional, Felic, Artur, additional, Sesana, Michele, additional, Sanguini, Roberto, additional, Huertas, Lina, additional, Rotondi, Domenico, additional, and Cecil, Joe, additional

Published
2022
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27. Nutritional support in surgical oncology: A survey by SICO in collaboration with the Intersociety Italian Working Group for Nutritional Support in Cancer Patients

Author

Aprile, Giuseppe, Bossi, Paolo, Farina, Gabriella, Pedrazzoli, Paolo, Stragliotto, Silvia, Caccialanza, Riccardo, Corradi, Ettore, Cotogni, Paolo, Mascheroni, Annalisa, Riso, Sergio, De Lorenzo, Francesco, Iannelli, Elisabetta, Traclò, Francesca, Grieco, Michele, Delrio, Paolo, De Luca, Raffaele, Sandini, Marta, Gnagnarella, Patrizia, Monge, Taira, Lorenzon, Laura, Agnes, Amedea Luciana, Santoro, Gloria, Roviello, Franco, and Carlini, Massimo

Published
2022
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28. Outcomes of the SARS-CoV-2 omicron (B.1.1.529) variant outbreak among vaccinated and unvaccinated patients with cancer in Europe: results from the retrospective, multicentre, OnCovid registry study

Author

Evans, Joanne S, Swallow, Judith, Chung, Chris, Patel, Meera, Dettorre, Gino, Ottaviani, Diego, Chowdhury, Amani, Merry, Eve, Chopra, Neha, Lee, Alvin JX, Sng, Christopher CT, Yu, Tamara, Shawe-Taylor, Marianne, Bain, Hamish DC, Wong, Yien Ning Sophia, Galazi, Myria, Benafif, Sarah, Dileo, Palma, Earnshaw, Irina, Patel, Grisma, Wu, Anjui, Soosaipillai, Gehan, Cooper, Lee, Andaleeb, Ramis, Dolly, Saoirse, Apthorp, Eleanor, Srikandarajah, Krishnie, Jones, Eleanor, Van Hemelrijck, Mieke, Moss, Charlotte, Russell, Beth, Chester, John, Loizidou, Angela, Piccart, Martine, Cruz, Claudia A, Reyes, Roxana, Segui, Elia, Marco-Hernández, Javier, Viladot, Margarita, Eremiev, Simeon, Fort-Culillas, Roser, Garcia, Isabel, Liñan, Raquel, Roqué Lloveras, Ariadna, Harbeck, Nadia, Wuerstlein, Rachel, Henze, Franziska, Mahner, Sven, Felip, Eudald, Pous, Anna, D'Avanzo, Francesca, Scotti, Lorenza, Krengli, Marco, Marrari, Andrea, Delfanti, Sara, Maconi, Antonio, Betti, Marta, Tonini, Giuseppe, Di Fazio, Giuseppina Rita, Tondini, Carlo, Chiudinelli, Lorenzo, Franchi, Michela, Libertini, Michela, Bertulli, Rossella, Baggi, Alice, Tovazzi, Valeria, Ficorella, Corrado, Porzio, Giampiero, Saponara, Maristella, Filetti, Marco, Zoratto, Federica, Paoloni, Francesco, Berardi, Rossana, Guida, Annalisa, Bracarda, Sergio, Iglesias, Maria, Sanchez de Torre, Ana, Tagliamento, Marco, Colomba, Emeline, Pommeret, Fanny, Pinato, David J, Aguilar-Company, Juan, Ferrante, Daniela, Hanbury, Georgina, Bower, Mark, Salazar, Ramon, Mirallas, Oriol, Sureda, Anna, Plaja, Andrea, Cucurull, Marc, Mesia, Ricard, Townsend, Sarah, Jackson, Amanda, Dalla Pria, Alessia, Newsom-Davis, Thomas, Handford, Jasmine, Sita-Lumsden, Ailsa, Vincenzi, Bruno, Bertuzzi, Alexia, Brunet, Joan, Lambertini, Matteo, Maluquer, Clara, Pedrazzoli, Paolo, Biello, Federica, Sinclair, Alasdair, Bawany, Samira, Khalique, Saira, Rossi, Sabrina, Rogers, Lucy, Murphy, Cian, Belessiotis, Katherine, Carmona-García, M Carmen, Sharkey, Rachel, García-Illescas, David, Rizzo, Gianpiero, Perachino, Marta, Saoudi-Gonzalez, Nadia, Doonga, Kris, Fox, Laura, Roldán, Elisa, Gaidano, Gianluca, Ruiz-Camps, Isabel, Bruna, Riccardo, Patriarca, Andrea, Martinez-Vila, Clara, Cantini, Luca, Zambelli, Alberto, Giusti, Raffaele, Mazzoni, Francesca, Caliman, Enrico, Santoro, Armando, Grosso, Federica, Parisi, Alessandro, Queirolo, Paola, Aujayeb, Avinash, Rimassa, Lorenza, Prat, Aleix, Tucci, Marco, Grisanti, Salvatore, Mukherjee, Uma, Diamantis, Nikolaos, Fusco, Vittorio, Generali, Daniele, Provenzano, Salvatore, Gennari, Alessandra, Tabernero, Josep, and Cortellini, Alessio

Published
2022
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29. Multicentre, randomised, open-label, parallel-group, clinical phase II study to evaluate immunonutrition in improving efficacy of immunotherapy in patients with metastatic non-small cell lung cancer, undergoing systematic nutritional counseling

Author

Caccialanza, Riccardo, Cereda, Emanuele, Agustoni, Francesco, Klersy, Catherine, Casirati, Amanda, Montagna, Elisabetta, Carnio, Simona, Novello, Silvia, Milella, Michele, Pilotto, Sara, Trestini, Ilaria, Buffoni, Lucio, Ferrari, Alessandra, and Pedrazzoli, Paolo

Published
2022
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30. Phase I Clinical Trial on Pleural Mesothelioma Using Neoadjuvant Local Administration of Paclitaxel-Loaded Mesenchymal Stromal Cells (PACLIMES Trial): Study Rationale and Design.

Author

Stella, Giulia Maria, Lisini, Daniela, Pedrazzoli, Paolo, Galli, Giulia, Bortolotto, Chandra, Melloni, Giulio, D'Ambrosio, Gioacchino, Klersy, Catherine, Grosso, Amelia, Paino, Francesca, Tomaselli, Stefano, Saracino, Laura, Alessandri, Giulio, Pessina, Augusto, Grignani, Elena, Rosti, Vittorio, Corsico, Angelo Guido, Comoli, Patrizia, and Agustoni, Francesco

Subjects
MESENCHYMAL stem cells, CLINICAL trials, PLEURAL tumors, TREATMENT effectiveness, COMBINED modality therapy, MESOTHELIOMA, PACLITAXEL
Abstract

Simple Summary: The phase I monocentric PACLIMES trial evaluates the effects of local administration of an innovative tool composed of mesenchymal stromal cells loaded with paclitaxel directly injected in the pleural space in mesothelioma patients in a neoadjuvant setting. The trial explores the safety and toxicity of the drug product, but also an exploratory objective aimed at evaluating its antiproliferative capacity. The results of this study will validate a promising therapeutic option for an unmet clinical need such as pleural mesothelioma and open the way to an efficient management of malignant pleural effusion in case of advanced cancers from different sites of primary origin. Background and rationale. Pleural mesothelioma (PM) is a rare and aggressive neoplasm that originates from the pleural mesothelium and whose onset is mainly linked to exposure to asbestos, which cannot be attacked with truly effective therapies with consequent poor prognosis. The rationale of this study is based on the use of mesenchymal stromal cells (MSCs) as a vehicle for chemotherapy drugs to be injected directly into the pathological site, such as the pleural cavity. Study design. The study involves the use of a conventional chemotherapeutic drug, Paclitaxel (PTX), which is widely used in the treatment of different types of solid tumors, including PM, although some limitations are related to pharmacokinetic aspects. The use of PTX-loaded MSCs to treat PM should provide several potential advantages over the systemically administered drug as reduced toxicity and increased concentration of active drug in the tumor-surrounding context. The PACLIMES trial explores the safety and toxicity of the local administration of Paclimes in chemonaive patients, candidates for pleurectomy. The secondary objective is to find the effective Paclimes dose for subsequent phase II studies and to observe and record the antitumor activity. Future direction. The experimental pre-clinical background and rationale are discussed as well. [ABSTRACT FROM AUTHOR]

Published
2024
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31. Extending factory digital Twins through human characterisation in Asset Administration Shell.

Author

Cutrona, Vincenzo, Bonomi, Niko, Montini, Elias, Ruppert, Tamas, Delinavelli, Giacomo, and Pedrazzoli, Paolo

Abstract

This paper extends the traditional factory digital twins by incorporating human characterisation in Asset Administration Shell (AAS). The extension lays the basis for human-centred control and management, as demonstrated by employing a prototype of the extended AAS in two proposed use cases. Referred to Industry 5.0, an accurate digital representation of humans as a basis of the data-based decision support to improve operators' well-being and resilience. The AAS is extended to include dedicated digital models accommodating a set of properties to describe the human operators and its interactions with the surrounding shop-floor resources. Two reference use cases have been designed in the context of a complete lab-scale manufacturing system: equipment and devices have been modelled according to the AAS standard, exposing information via MQTT, and have been integrated with the proposed AAS definition of human operators. Operators have been equipped with wearable sensors and a dashboard providing them with feedback from the manufacturing environment and notifications about changes. As part of the extension process, some ethical and regulation concerns are discussed, highlighting that the extended AAS is mature enough to support the inclusion of human operators, but regulations struggle to keep up with technological advances. [ABSTRACT FROM AUTHOR]

Published
2024
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32. Unlocking the Potential: Epstein-Barr Virus (EBV) in Gastric Cancer and Future Treatment Prospects, a Literature Review.

Author

Corallo, Salvatore, Lasagna, Angioletta, Filippi, Beatrice, Alaimo, Domiziana, Tortorella, Anna, Serra, Francesco, Vanoli, Alessandro, and Pedrazzoli, Paolo

Subjects
HELICOBACTER pylori infections, IMMUNE checkpoint inhibitors, LITERATURE reviews, GASTRIC mucosa, STOMACH cancer
Abstract

Gastric cancer (GC) is a complex disease with various etiologies. While Helicobacter pylori infection is still one of the leading risk factors for GC, increasing evidence suggests a link between GC and other infective agents such as Epstein Bar Virus (EBV). EBV-associated gastric cancer (EBVaGC) is now recognized as a distinct subgroup of GC, and the complex interactions between the virus and gastric mucosa may influence its development. A recent integrative analysis of the genome and proteome of GC tissues by The Cancer Genome Atlas project has identified EBVaGC as a specific subtype characterized by PIK3CA and ARID1A mutations, extensive DNA hyper-methylation, and activation of immune signaling pathways. These molecular characteristics are markers of the unique molecular profile of this subset of GC and are potential targets for therapy. This review aims to provide an overview of the current knowledge on EBVaGC. It will focus on the epidemiology, clinic-pathological features, and genetic characteristics of EBVaGC. Additionally, it will discuss recent data indicating the potential use of EBV infection as a predictive biomarker of response to chemotherapy and immune checkpoint inhibitors. The review also delves into potential therapeutic approaches for EBVaGC, including targeted therapies and adoptive immunotherapy, highlighting the promising potential of EBV as a therapeutic target. [ABSTRACT FROM AUTHOR]

Published
2024
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36. Prevalence and impact of COVID-19 sequelae on treatment and survival of patients with cancer who recovered from SARS-CoV-2 infection: evidence from the OnCovid retrospective, multicentre registry study

Author

Swallow, Judith, Chung, Chris, Dettorre, Gino, Chopra, Neha, Lee, Alvin JX, Sng, Christopher CT, Wong, Yien Ning Sophia, Galazi, Myria, Benafif, Sarah, Dileo, Palma, Patel, Grisma, Wu, Anjui, Sinclair, Alasdair, Soosaipillai, Gehan, Jones, Eleanor, Diamantis, Nikolaos, Mukherjee, Uma, Jackson, Amanda, Piccart, Martine, Pommeret, Fanny, Colomba, Johann, Colomba-Blameble, Emeline, Prat, Aleix, Cruz, Claudia A, Reyes, Roxana, Segui, Elia, Marco-Hernández, Javier, Tabernero, Josep, Aguilar-Company, Juan, Ruiz-Camps, Isabel, Fox, Laura, Garcia Illescas, David, Mirallas, Oriol, Roldán, Elisa, Carbó, Anna, Garcia, Isabel, Wuerstlein, Rachel, Mesia, Ricard, Maluquer, Clara, D'Avanzo, Francesca, Tonini, Giuseppe, Provenzano, Salvatore, Tovazzi, Valeria, Ficorella, Corrado, Queirolo, Paola, Giusti, Raffaele, Mazzoni, Francesca, Zoratto, Federica, Tucci, Marco, Berardi, Rossana, Guida, Annalisa, Bracarda, Sergio, Iglesias, Maria, Pinato, David J, Bower, Mark, Scotti, Lorenza, Patel, Meera, Colomba, Emeline, Dolly, Saoirse, Loizidou, Angela, Chester, John, Zambelli, Alberto, Dalla Pria, Alessia, Ottaviani, Diego, Chowdhury, Amani, Merry, Eve, Salazar, Ramon, Bertuzzi, Alexia, Brunet, Joan, Lambertini, Matteo, Tagliamento, Marco, Pous, Anna, Sita-Lumsden, Ailsa, Srikandarajah, Krishnie, Seguí, Elia, Generali, Daniele, Grisanti, Salvatore, Pedrazzoli, Paolo, Rizzo, Gianpiero, Libertini, Michela, Moss, Charlotte, Evans, Joanne S, Russell, Beth, Harbeck, Nadia, Vincenzi, Bruno, Biello, Federica, Bertulli, Rossella, Liñan, Raquel, Rossi, Sabrina, Carmona-García, Maria Carmen, Tondini, Carlo, Baggi, Alice, Fotia, Vittoria, Parisi, Alessandro, Porzio, Giampero, Saponara, Maristella, Cruz, Claudia Andrea, García-Illescas, David, Felip, Eudald, Roqué Lloveras, Ariadna, Sharkey, Rachel, Earnshaw, Irina, Ferrante, Daniela, Gaidano, Gianluca, Patriarca, Andrea, Bruna, Riccardo, Sureda, Anna, Martinez-Vila, Clara, Sanchez de Torre, Ana, Cantini, Luca, Filetti, Marco, Rimassa, Lorenza, Chiudinelli, Lorenzo, Franchi, Michela, Krengli, Marco, Santoro, Armando, Van Hemelrijck, Mieke, Newsom-Davis, Thomas, Gennari, Alessandra, and Cortellini, Alessio

Published
2021
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41. Gemcitabine with or without ramucirumab as second-line treatment for malignant pleural mesothelioma (RAMES): a randomised, double-blind, placebo-controlled, phase 2 trial

Author

Pinto, Carmine, Zucali, Paolo Andrea, Pagano, Maria, Grosso, Federica, Pasello, Giulia, Garassino, Marina Chiara, Tiseo, Marcello, Soto Parra, Hector, Grossi, Francesco, Cappuzzo, Federico, de Marinis, Filippo, Pedrazzoli, Paolo, Bonomi, Maria, Gianoncelli, Letizia, Perrino, Matteo, Santoro, Armando, Zanelli, Francesca, Bonelli, Candida, Maconi, Antonio, Frega, Stefano, Gervasi, Erika, Boni, Luca, and Ceresoli, Giovanni Luca

Published
2021
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43. Influence of different lipid emulsions on specific immune cell functions in head and neck cancer patients receiving supplemental parenteral nutrition: An exploratory analysis

Author

Candiloro, Francesca, Borioli, Valeria, Borsellino, Giovanna, Picozza, Mario, Pellini, Raul, Cereda, Emanuele, Gargano, Francesca, Caraccia, Marilisa, R.D., Nardi, Maria Teresa, Bellu, Luisa, Tondulli, Luca, Imarisio, Ilaria, Pozzi, Emma, Pedrazzoli, Paolo, Caccialanza, Riccardo, and Battistini, Luca

Published
2021
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44. Author Correction: Tissue fluidification promotes a cGAS–STING cytosolic DNA response in invasive breast cancer

Author

Frittoli, Emanuela, Palamidessi, Andrea, Iannelli, Fabio, Zanardi, Federica, Villa, Stefano, Barzaghi, Leonardo, Abdo, Hind, Cancila, Valeria, Beznoussenko, Galina V., Della Chiara, Giulia, Pagani, Massimiliano, Malinverno, Chiara, Bhattacharya, Dipanjan, Pisati, Federica, Yu, Weimiao, Galimberti, Viviana, Bonizzi, Giuseppina, Martini, Emanuele, Mironov, Alexander A., Gioia, Ubaldo, Ascione, Flora, Li, Qingsen, Havas, Kristina, Magni, Serena, Lavagnino, Zeno, Pennacchio, Fabrizio Andrea, Maiuri, Paolo, Caponi, Silvia, Mattarelli, Maurizio, Martino, Sabata, d’Adda di Fagagna, Fabrizio, Rossi, Chiara, Lucioni, Marco, Tancredi, Richard, Pedrazzoli, Paolo, Vecchione, Andrea, Petrini, Cristiano, Ferrari, Francesco, Lanzuolo, Chiara, Bertalot, Giovanni, Nader, Guilherme, Foiani, Marco, Piel, Matthieu, Cerbino, Roberto, Giavazzi, Fabio, Tripodo, Claudio, and Scita, Giorgio

Published
2023
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46. Long-term survival in a fraction of patients with metastatic breast cancer who received consolidation therapy with high-dose chemotherapy and autologous stem cell transplant between 2000 and 2015: an EBMT registry-based study

Author

Martino, Massimo, Pitino, Annalisa, Gori, Mercedes, Viens, Patrice, Siena, Salvatore, Tripepi, Giovanni, Canale, Filippo Antonio, Ballestrero, Alberto, Zamagni, Claudio, Musso, Maurizio, Zambelli, Alberto, Dreger, Peter, Badoglio, Manuela, Secondino, Simona, Console, Giuseppe, Chabannon, Christian, and Pedrazzoli, Paolo

Published
2022
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49. Anticancer restrictive diets and the risk of psychological distress: Review and perspectives.

Author

Da Prat, Valentina, Pravettoni, Gabriella, Casirati, Amanda, Marzorati, Chiara, Pedrazzoli, Paolo, and Caccialanza, Riccardo

Subjects
PSYCHOLOGICAL distress, PSYCHOLOGICAL factors, DIET, CLINICAL trials, WEIGHT loss, COMPULSIVE eating
Abstract

Introduction: The most studied anticancer restrictive diets include fasting, fasting‐mimicking diets (FMDs) and ketogenic diets (KDs). Besides the current lack of established clinical benefit and the significant risk of malnutrition and micronutrient deficiencies, dietary restrictions in cancer patients might have relevant psychological effects. Materials and Methods: We reviewed the randomized and non‐randomized controlled clinical trials (CCTs) reporting data on the psychological impact of fasting, FMDs and KDs in cancer patients. We excluded trials on restrictive diets performed for weight reduction in obese or overweight patients, studies on dietary restrictions lasting less than 24 h, and studies on fasting related to cultural or religious beliefs. Results: Three CCTs on fasting or FMDs and eight CCTs on KDs in cancer patients were included. In terms of diet‐related distress, emotional, social, and family well‐being, none of these studies showed a detrimental impact of fasting, FMDs and KDs. However, clinical trials specifically assessing the psychological aspects in the long term are lacking. Conclusions and Perspectives: In the absence of a conclusive evidence on the clinical benefits of restrictive diets, which carry significant risks especially if unsupervised, further studies are needed to clarify their psychological impact in cancer patients. Multidisciplinary approaches including psychological evaluations should be used to ameliorate patient selection for clinical trials, identify early distress symptoms, and increase patient compliance to dietary recommendations. [ABSTRACT FROM AUTHOR]

Published
2024
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