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395 results on '"Pedley, Timothy A."'

1. Stability of arrays of bottom-heavy spherical squirmers

Author

Brumley, Douglas R. and Pedley, Timothy J.

Subjects
Physics - Fluid Dynamics, Condensed Matter - Soft Condensed Matter, Physics - Biological Physics
Abstract

The incessant swimming motion of microbes in dense suspensions can give rise to striking collective motions and coherent structures. However, theoretical investigations of these structures typically utilize either computationally demanding numerical simulations, or simplified continuum models. Here we analytically investigate the collective dynamics of a dense array of steady, spherical squirmers. We first calculate the forces and torques acting on two closely-separated squirmers, through solving the Stokes equations to second-order in the ratio of mean spacing to squirmer radius. This lubrication analysis is then used to assess the stability of a dense, vertical, planar array of identical three-dimensional squirmers. The system of uniformly-spaced, vertically-oriented squirmers is stable if the gravitational torque experienced due to bottom-heaviness is sufficiently strong, and an intercellular repulsive force is included. The predictions of instability and possible long time behavior is qualitatively similar for monolayers confined between two parallel rigid planes as for unconfined monolayers. The predictions compare favorably with published numerical simulations, and reveal the existence of additional dynamic structures not previously observed; puller-type squirmers show a greater range of structures than pushers. The use of pairwise lubrication interactions provides an efficient means of assessing stability of dense suspensions usually tackled using full numerical simulations., Comment: 22 pages, 13 figures

Published
2019
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2. Metachronal waves in the flagellar beating of $Volvox$ and their hydrodynamic origin

Author

Brumley, Douglas R., Polin, Marco, Pedley, Timothy J., and Goldstein, Raymond E.

Subjects
Condensed Matter - Soft Condensed Matter, Quantitative Biology - Cell Behavior
Abstract

Groups of eukaryotic cilia and flagella are capable of coordinating their beating over large scales, routinely exhibiting collective dynamics in the form of metachronal waves. The origin of this behaviour -- possibly influenced by both mechanical interactions and direct biological regulation -- is poorly understood, in large part due to lack of quantitative experimental studies. Here we characterise in detail flagellar coordination on the surface of the multicellular alga $Volvox~carteri$, an emerging model organism for flagellar dynamics. Our studies reveal for the first time that the average metachronal coordination observed is punctuated by periodic phase defects during which synchrony is partial and limited to specific groups of cells. A minimal model of hydrodynamically coupled oscillators can reproduce semi-quantitatively the characteristics of the average metachronal dynamics, and the emergence of defects. We systematically study the model's behaviour by assessing the effect of changing intrinsic rotor characteristics, including oscillator stiffness and the nature of their internal driving force, as well as their geometric properties and spatial arrangement. Our results suggest that metachronal coordination follows from deformations in the oscillators' limit cycles induced by hydrodynamic stresses, and that defects result from sufficiently steep local biases in the oscillators' intrinsic frequencies. Additionally, we find that random variations in the intrinsic rotor frequencies increase the robustness of the average properties of the emergent metachronal waves., Comment: 16 pages, 15 figures (Including Supplementary Information); Journal of the Royal Society Interface, in press (2015)

Published
2015

3. Dancing Volvox: Hydrodynamic Bound States of Swimming Algae

Author

Drescher, Knut, Leptos, Kyriacos C., Tuval, Idan, Ishikawa, Takuji, Pedley, Timothy J., and Goldstein, Raymond E.

Subjects
Condensed Matter - Soft Condensed Matter
Abstract

The spherical alga Volvox swims by means of flagella on thousands of surface somatic cells. This geometry and its large size make it a model organism for studying the fluid dynamics of multicellularity. Remarkably, when two nearby Volvox swim close to a solid surface, they attract one another and can form stable bound states in which they "waltz" or "minuet" around each other. A surface-mediated hydrodynamic attraction combined with lubrication forces between spinning, bottom-heavy Volvox explains the formation, stability and dynamics of the bound states. These phenomena are suggested to underlie observed clustering of Volvox at surfaces., Comment: 4 pages, 5 figures

Published
2009
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4. Bacterial tracking of motile algae assisted by algal cell's vorticity field

Author

Locsei, Janos Tobias and Pedley, Timothy J

Subjects
Quantitative Biology - Cell Behavior, Quantitative Biology - Quantitative Methods
Abstract

Previously published experimental work by other authors has shown that certain motile marine bacteria are able to track free swimming algae by executing a zigzag path and steering toward the algae at each turn. Here, we propose that the apparent steering behaviour could be a hydrodynamic effect, whereby an algal cell's vorticity and strain-rate fields rotate a pursuing bacterial cell in the appropriate direction. Using simplified models for the bacterial and algal cells, we numerically compute the trajectory of a bacterial cell and demonstrate the plausibility of this hypothesis., Comment: 21 pages, 15 figures

Published
2008

6. Sharp turns and gyrotaxis modulate surface accumulation of microorganisms

Author

Zeng, Li, Jiang, Weiquan, Pedley, Timothy J, Zeng, Li [0000-0002-6547-2602], Jiang, Weiquan [0000-0002-2528-7736], Pedley, Timothy J [0000-0001-8407-8945], and Apollo - University of Cambridge Repository

Subjects
surface accumulation, Multidisciplinary, rotational diffusion, Flagella, gyrotaxis, swimming microorganisms, Hydrodynamics, Models, Biological, Stramenopiles, Swimming
Abstract

The accumulation of swimming microorganisms at surfaces is an essential feature of various physical, chemical, and biological processes in confined spaces. To date, this accumulation is mainly assumed to depend on the change of swimming speed and angular velocity caused by cell-wall contact and hydrodynamic interaction. Here, we measured the swimming trajectories of Heterosigma akashiwo (a biflagellate marine alga) near vertical and horizontal rigid boundaries. We observed that the probability of sharp turns is greatly increased near a vertical wall, resulting in significant changes in the distributions of average swimming speed, angular velocity, and rotational diffusivity near the wall (a quantity that has not previously been investigated) as functions of both distance from the wall and swimming orientation. These cannot be satisfactorily explained by standard hydrodynamic models. Detailed examination of an individual cell trajectory shows that wall contact by the leading flagellum triggers complex changes in the behavior of both flagella that cannot be incorporated in a mechanistic model. Our individual-based model for predicting cell concentration using the measured distributions of swimming speed, angular velocity, and rotational diffusivity agrees well with the experiment. The experiments and model are repeated for a cell suspension in a vertical plane, bounded above by a horizontal wall. The cell accumulation beneath the wall, expected from gyrotaxis, is considerably amplified by cell-wall interaction. These findings may shed light on the prediction and control of cell distribution mediated by gyrotaxis and cell-wall contact.

Published
2022

7. Introduction

Author

Carpenter, Peter W., Pedley, Timothy J., Moreau, R., editor, Carpenter, Peter W., editor, and Pedley, Timothy J., editor

Published
2003
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8. Arterial and Venous Fluid Dynamics

Author

Pedley, Timothy J., Velarde, Manuel Garcia, editor, Sayir, Mahir, editor, Schneider, Wilhelm, editor, Schrefler, Bernhard, editor, Bianchi, Giovanni, editor, Tasso, Carlo, editor, Pedrizzetti, Gianni, editor, and Perktold, Karl, editor

Published
2003
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10. Sharp turns and gyrotaxis modulate surface accumulation of microorganisms.

Author

Li Zeng, Weiquan Jiang, and Pedley, Timothy J.

Subjects
ANGULAR velocity, CELL suspensions, MARINE algae, ROTATIONAL diffusion, MICROORGANISMS
Abstract

The accumulation of swimming microorganisms at surfaces is an essential feature of various physical, chemical, and biological processes in confined spaces. To date, this accumulation is mainly assumed to depend on the change of swimming speed and angular velocity caused by cell-wall contact and hydrodynamic interaction. Here, we measured the swimming trajectories ofHeterosigma akashiwo (a biflagellate marine alga) near vertical and horizontal rigid boundaries.We observed that the probability of sharp turns is greatly increased near a vertical wall, resulting in significant changes in the distributions of average swimming speed, angular velocity, and rotational diffusivity near the wall (a quantity that has not previously been investigated) as functions of both distance from the wall and swimming orientation. These cannot be satisfactorily explained by standard hydrodynamic models. Detailed examination of an individual cell trajectory shows that wall contact by the leading flagellum triggers complex changes in the behavior of both flagella that cannot be incorporated in a mechanistic model. Our individual-based model for predicting cell concentration using the measured distributions of swimming speed, angular velocity, and rotational diffusivity agrees well with the experiment. The experiments and model are repeated for a cell suspension in a vertical plane, bounded above by a horizontal wall. The cell accumulation beneath the wall, expected from gyrotaxis, is considerably amplified by cell-wall interaction. These findings may shed light on the prediction and control of cell distribution mediated by gyrotaxis and cell-wall contact. [ABSTRACT FROM AUTHOR]

Published
2022
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13. Initial management of epilepsy

Author

French, Jacqueline A. and Pedley, Timothy A.

Subjects
Anticonvulsants -- Dosage and administration, Anticonvulsants -- Complications and side effects, Epilepsy -- Case studies, Epilepsy -- Diagnosis, Epilepsy -- Care and treatment
Abstract

The symptoms, causes, diagnosis and treatment methodologies for epilepsy are discussed through the case study of a 29 year old woman. Certain guidelines that have been set for the pharmacological selection of therapy of epileptic patients are also highlighted.

Published
2008

16. Contributors

Author

Abou-Khalil, Bassel W., primary, Adamczyk, Peter, additional, Ajtai, Bela, additional, Allen, Jeffrey C., additional, Amato, Anthony A., additional, Aminoff, Michael J., additional, Apostolova, Liana G., additional, Avidan, Alon Y., additional, Baehring, Joachim M., additional, Balcer, Laura J., additional, Baloh, Robert W., additional, Barkhoudarian, Garni, additional, Bartleson, J.D., additional, Batchelor, Tracy T., additional, Beckham, J. David, additional, Beglinger, Leigh, additional, Berger, Joseph R., additional, Bergsneider, Marvin, additional, Bethoux, Francois, additional, Biller, José, additional, Black, David F., additional, Boes, Christopher J., additional, Boulis, Nicholas, additional, Bramlett, Helen M., additional, Brooke, Michael H., additional, Bruni, Joseph, additional, Burnette, W. Bryan, additional, Buttner, Edgar A., additional, Capobianco, David J., additional, Carson, Alan, additional, Cavaliere, Robert, additional, Chad, David A., additional, Chelimsky, Gisela, additional, Chelimsky, Thomas, additional, Cheshire, William P., additional, Chitnis, Tanuja, additional, Chokroverty, Sudhansu, additional, Cooper, Paul E., additional, Cummings, Jeffrey L., additional, Cutrer, F. Michael, additional, Dalmau, Josep, additional, Daroff, Robert B., additional, DasGupta, Ranan, additional, DeKosky, Steven T., additional, Dietrich, W. Dalton, additional, Dobkin, Bruce H., additional, Doty, Richard L., additional, Duckwiler, Gary, additional, Dusick, Joshua R., additional, Emerson, Ronald G., additional, Fenichel, Gerald M., additional, Fessler, Richard G., additional, Flores-Sarnat, Laura, additional, Fogel, Brent L., additional, Fowler, Clare J., additional, Fugate, Jennifer E., additional, Gallager, Martin J., additional, Gardner, Sharon L., additional, Garza, Ivan, additional, Gehl, Carissa, additional, Geldmacher, David S., additional, Geschwind, Daniel H., additional, Geschwind, Michael D., additional, Golomb, Meredith R., additional, Gonzalez, Nestor, additional, Hallett, Mark, additional, Hamati, Aline I., additional, Havton, Leif A., additional, Heffner, Reid R., additional, Hill, Alan, additional, Hochberg, Fred H., additional, Houtchens, Maria K., additional, Islam, Monica P., additional, Jankovic, Joseph, additional, Jansen, Michael, additional, Josephson, S. Andrew, additional, Karajannis, Matthias A., additional, Kase, Carlos S., additional, Katirji, Bashar, additional, Kerber, Kevin A., additional, Kerchner, Geoffrey A., additional, Khoury, Samia J., additional, Kirshner, Howard S., additional, Koontz, Daniel, additional, Koshy, Anita, additional, Kremen, Sarah A., additional, Kula, Roger W., additional, Kumar, Abhay, additional, Kurtzke, John F., additional, Lang, Anthony E., additional, Lavin, Patrick J.M., additional, Liebeskind, David S., additional, Lindzen, Eric, additional, Lockwood, Alan H., additional, Louis, David N., additional, Love, Betsy B., additional, Lublin, Fred D., additional, Macdonald, Robert L., additional, Mack, William, additional, Martin, Neil, additional, Masdeu, Joseph C., additional, Mazziotta, John C., additional, Mendez, Mario F., additional, Meriggioli, Matthew N., additional, Meyer, Philipp T., additional, Michaud, Dominique S., additional, Miller, Aaron E., additional, Misulis, Karl E., additional, Mitsumoto, Hiroshi, additional, Murray, Brian, additional, Murray, Evan D., additional, Nass, Ruth, additional, Nutt, John G., additional, Nuwer, Marc R., additional, Okun, Michael S., additional, O’Rourke, Justin J.F., additional, Pandey, Ajay K., additional, Panicker, Jalesh N., additional, Pastores, Gregory M., additional, Paulsen, Jane S., additional, Pedley, Timothy A., additional, Perry, Arie, additional, Pestronk, Alan, additional, Pfeiffer, Ronald F., additional, Prasad, Sashank, additional, Preston, David C., additional, Price, Bruce H., additional, Ptáček, Louis J., additional, Rabinstein, Alejandro A., additional, Reimschisel, Tyler, additional, Remler, Bernd F., additional, Rijntjes, Michel, additional, Roach, E. Steve, additional, Robertson, David, additional, Rogers, Lisa R., additional, Ronthal, Michael, additional, Roos, Karen, additional, Rosenbaum, Richard B., additional, Rosenberg, Gary A., additional, Rosenfeld, Myrna R., additional, Ross, Gail, additional, Rucker, Janet C., additional, Sanders, Donald B., additional, Sarnat, Harvey B., additional, Savani, Aman, additional, Schapira, Anthony H.V., additional, Schiff, David, additional, Schmidley, James W., additional, Schneck, Michael J., additional, Shaner, D. Malcolm, additional, Shapiro, Barbara E., additional, Shih, Patrick, additional, Simon, Roger P., additional, So, Yuen T., additional, Sohn, Young H., additional, Solbrig, Marylou V., additional, Stippler, Martina, additional, Stoessl, A. Jon, additional, Stone, Jon, additional, Subramony, S.H., additional, Swanson, Jerry W., additional, Tateshima, Satoshi, additional, Thompson, Philip D., additional, Thurtell, Matthew J., additional, Tomsak, Robert L., additional, Tsai, Po-Heng, additional, Tsao, Bryan, additional, Turner, Chris, additional, Tyler, Kenneth L., additional, Vargas, Bert B., additional, Verma, Ashok, additional, Vinuela, Fernando, additional, Wall, Michael, additional, Wallin, Mitchell T., additional, Wang, Leo H., additional, Weiller, Cornelius, additional, Wen, Patrick, additional, Wijdicks, Eelco F.M., additional, Xia, Guangbin, additional, Zenteno, Marco, additional, Zhou, Jiachen, additional, and Zhou, YiLi, additional

Published
2012
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18. Contributing Authors

Author

Anderson, Gail D., primary, Antozzi, Carlo, additional, Baram, Tallie Z., additional, Battino, Dina, additional, Bertram, Edward H., additional, Boon, Paul, additional, Chiron, Catherine, additional, Depondt, Chantal, additional, Dubé, Céline M., additional, Ebersole, John S., additional, Goodkin, Howard P., additional, Granata, Tiziana, additional, Guerrini, Renzo, additional, Kanner, Andres M., additional, Klitgaard, Henrik, additional, Koutroumanidis, Michael, additional, Krieger, David, additional, Lemieux, Louis, additional, Litt, Brian, additional, Mari, Francesco, additional, Marson, Anthony G., additional, Matagne, Alain, additional, Mendiratta, Anil, additional, Moran, Nicholas, additional, Nashef, Lina, additional, Noachtar, Soheyl, additional, Panayiotopoulos, Chrysostomos P., additional, Pedley, Timothy A., additional, Rémi, Jan, additional, Rho, Jong M., additional, Rugg-Gunn, Fergus J., additional, Shorvon, Simon, additional, Thornton, Rachel, additional, Tomson, Torbjörn, additional, and Vonck, Kristl, additional

Published
2009
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19. PREFACE

Author

Shorvon, Simon, primary and Pedley, Timothy A., additional

Published
2009
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23. Contributors

Author

Allen, Jeffrey C., primary, Alshehri, Abdulrahim M., additional, Amato, Anthony A., additional, Aminoff, Michael J., additional, Ashwal, Stephen, additional, Asir, Alparslan, additional, Babikian, Viken L., additional, Baehring, Joachim M., additional, Balcer, Laura J., additional, Baloh, Robert W., additional, Bartleson, J.D., additional, Batchelor, Tracy T., additional, Berger, Joseph R., additional, Bethoux, Francois, additional, Bhatia, Rita G., additional, Biller, José, additional, Bird, Thomas D., additional, Black, David F., additional, Blackham, Kristine, additional, Blackman, Samuel C., additional, Boes, Christopher J., additional, Bosch, E. Peter, additional, Boulis, Nicholas, additional, Bowen, Brian C., additional, Bradley, Walter G., additional, Bramlett, Helen M., additional, Brooke, Michael H., additional, Bruni, Joseph, additional, Byrne, Thomas N., additional, Capobianco, David J., additional, Chad, David A., additional, Chitnis, Tanuja, additional, Chokroverty, Sudhansu, additional, Ciaverella, David P., additional, Cooper, Paul E., additional, Cutrer, F. Michael, additional, Dalmau, Josep, additional, Daroff, Robert B., additional, DasGupta, Ranan, additional, DeKosky, Steven T., additional, Deshaies, Eric M., additional, Dietrich, W. Dalton, additional, Dobkin, Bruce H., additional, Dodick, David W., additional, Duff, Kevin, additional, Emerson, Ronald G., additional, Fenichel, Gerald M., additional, Fernandes Filho, J. Americo, additional, Fessler, Richard G., additional, Finelli, Pasquale F., additional, Flores-Sarnat, Laura, additional, Fowler, Clare J., additional, Gala, Vishal C., additional, Garza, Ivan, additional, Geldmacher, David S., additional, Gengo, Fran M., additional, Giglio, Pierre, additional, Gilbert, Mark, additional, Goldsmith, Ian L., additional, Golomb, Meredith R., additional, Rothi, Leslie J. Gonzalez, additional, Hallet, Mark, additional, Hamati, Aline I., additional, Hamilton, Ronald L., additional, Harati, Yadollah, additional, Heffner, Reid R., additional, Heilman, Kenneth M., additional, Heros, Deborah O., additional, Heros, Roberto C., additional, Hill, Alan, additional, Hirano, Michio, additional, Hochberg, Fred H., additional, Howard, James F., additional, Hsu, Daniel, additional, Islam, Monica P., additional, Jankovic, Joseph, additional, Kalita, Jayantee, additional, Kase, Carlos S., additional, Katirji, Bashar, additional, Kaufer, Daniel I., additional, Kerber, Kevin A., additional, Kerchner, Geoffrey A., additional, Khoury, Samia J., additional, Kim, Dae-Hyun, additional, Kirshner, Howard S., additional, Kurtzke, John F., additional, Lang, Anthony E., additional, Lavin, Patrick J.M., additional, Lenz, Robert A., additional, Lesser, Ronald P., additional, Linfante, Italo, additional, Lockwood, Alan H., additional, Lopez, Oscar L., additional, Alberola, Roberto López, additional, Louis, David N., additional, Love, Betsy B., additional, Lublin, Fred D., additional, Mair, Robert G., additional, Marion, Donald W., additional, McMurtray, Aaron, additional, Mehndiratta, Man Mohan, additional, Mendez, Mario F., additional, Michaud, Dominique S., additional, Michelson, David J., additional, Miller, Aaron E., additional, Misra, Usha Kant, additional, Misulis, Karl E., additional, Mitsumoto, Hiroshi, additional, Mizrahi, Eli M., additional, Moraes, Carlos T., additional, Morrison, David, additional, Murray, Brian, additional, Murray, Evan D., additional, Nass, Ruth, additional, Nehl, Carissa, additional, Panagariya, Ashok, additional, Pastores, Gregory M., additional, Paulsen, Jane S., additional, Pedley, Timothy A., additional, Perry, Arie, additional, Pestronk, Alan, additional, Pfeiffer, Ronald F., additional, Prasad, Sashank, additional, Preston, David C., additional, Price, Bruce H., additional, Ptáček, Louis J., additional, Rabinstein, Alejandro A., additional, Ratcheson, Robert A., additional, Remler, Bernd F., additional, Roach, E. Steve, additional, Robertson, David, additional, Robinson, Jenice A., additional, Ronthal, Michael, additional, Rosenbaum, Richard B., additional, Rosenberg, Gary A., additional, Rosenfeld, Myrna R., additional, Ross, Gail, additional, Rucker, Janet C., additional, Sadowski, Martin, additional, Saigal, Gaurav, additional, Sanders, Donald B., additional, Sandhu, Johnny S., additional, Sarnat, Harvey B., additional, Savani, Aman A., additional, Schiff, David, additional, Schmidley, James W., additional, Schneck, Michael J., additional, Schumacher, James M., additional, Selman, Warren R., additional, Shaner, D. Malcolm, additional, Shannon, Kathleen M., additional, Shapiro, Barbara E., additional, Simon, Roger P., additional, Sklar, Evelyn M.L., additional, So, Yuen T., additional, Sohn, Young H., additional, Solbrig, Marylou V., additional, Stoessl, A. Jon, additional, Subramony, S.H., additional, Swanson, Jerry W., additional, Tapscott, Stephen J., additional, Tarr, Robert W., additional, Tegeler, Charles H., additional, Thompson, Philip D., additional, Tomsak, Robert L., additional, Trescher, William H., additional, Tsao, Bryan, additional, Tyler, Kenneth L., additional, Valenstein, Edward, additional, Verma, Ashok, additional, Voloschin, Alfredo D., additional, Voyadzis, Jean-Marc, additional, Wakhloo, Ajay K., additional, Wall, Michael, additional, Wallin, Mitchell T., additional, Watson, Robert T., additional, Waxman, Stephen G., additional, Wen, Patrick, additional, Wijdicks, Eelco F.M., additional, Wisniewski, Thomas, additional, Wolk, David A., additional, and Zhou, YiLi, additional

Published
2008
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25. Contributors

Author

Aguzzi, Adriano, primary, Albers, James W., additional, Alger, Jeffry R., additional, Allen, Richard P., additional, Aranow, Cynthia, additional, Backonja, Misha-Miroslav, additional, Balmer, Curtis W., additional, Batchelor, Tracy, additional, Benarroch, Eduardo E., additional, Berciano, José, additional, Bertram, Edward H., additional, Bhatia, Radhika, additional, Biller, Jose, additional, Birbeck, Gretchen L., additional, Bleck, Thomas P., additional, Bosworth, Brian P., additional, Bowsher, David, additional, Brooks, Benjamin, additional, Bukelis, Irena, additional, Caronna, John J., additional, Carter, John C., additional, Cavaletti, Guido, additional, Chand, Pratap, additional, Chong, Ji Y., additional, Cleland, James C., additional, Colosimo, Carlo, additional, Condon, Timothy P., additional, Sander Connolly, E., additional, Cortopassi, Gino, additional, Crystal, Ronald G., additional, Cutting, Laurie E., additional, Dafer, Rima M., additional, Dalakas, Marinos C., additional, Dalmau, Josep, additional, de Saint Martin, Anne, additional, Detre, John A., additional, Dhawan, Vijay, additional, Diamond, Betty, additional, Patrick Andrews Drummond, Sean, additional, Eidelberg, David, additional, Eisenach, John H., additional, Elshihabi, Said, additional, Fan, QiWen, additional, Fealey, Robert D., additional, Ferrari, Michel D., additional, Ferriero, Donna M., additional, Fink, Gereon R., additional, Fischbeck, Kenneth H., additional, Furie, Karen, additional, Gálvez-Jiménez, Néstor, additional, Geser, Felix, additional, Glatzel, Markus, additional, Goadsby, Peter J., additional, Goldin, Alan L., additional, Greenland, Karen J., additional, Griggs, Robert C., additional, Gutmann, David H., additional, Hagel, Christian, additional, Hagerman, Paul J., additional, Harris, Kendra, additional, Hartung, Hans-Peter, additional, Hemmer, Bernhard, additional, Heppner, Frank L., additional, Herbert, Martha R., additional, Herrmann, David N., additional, Hirano, Michio, additional, Hirsch, Edouard, additional, Hoff, Julian T., additional, Hoon, Alexander H., additional, Hyman, Bradley T., additional, Jain, Samay, additional, Jänig, Wilfrid, additional, Jaradeh, Safwan S., additional, Jellinger, Kurt A., additional, Joyner, Michael J., additional, Kaufmann, Walter E., additional, Keep, Richard F., additional, Kellogg, Aaron, additional, Kieseier, Bernd C., additional, Kinsman, Stephen L., additional, Köller, Hubertus, additional, Kowal, Czeslawa, additional, Lamszus, Katrin, additional, Landzberg, Brian R., additional, Lev, Michael H., additional, Lieberman, David N., additional, Lim, Leland E., additional, Lipkin, Paul H., additional, Litvan, Irene, additional, London, Zachary, additional, Low, Phillip A., additional, Mackay, Meggan, additional, Mahowald, Mark W., additional, Manzo, Luigi, additional, Maragakis, Nicholas J., additional, Masdeu, Joseph C., additional, Mazzoni, Pietro, additional, McLean, Pamela J., additional, Mercadante, Sebastiano, additional, Meyer, Ana-Claire, additional, Mignot, Emmanuel, additional, Miller, Steven P., additional, Mostofsky, Stewart, additional, Mrugala, Maciej, additional, Newcomer, Anne, additional, Nobbio, Lucilla, additional, Noorbakhsh, Farshid, additional, Novak, Peter, additional, O'Donoghue, John L., additional, Orr, Harry T., additional, Fleming Outiero, Tiago, additional, Palestrant, David, additional, Pedley, Timothy A., additional, Perez-Velasquez, Jose-Luis, additional, Perlis, Michael L., additional, Persson, Anders I., additional, Phillips, Joanna J., additional, Piersall, Linda, additional, Pigeon, Wilfred R., additional, Pomerantz, Stuart R., additional, Pop-Busui, Rodica, additional, Power, Christopher, additional, Powers, James M., additional, Rando, Thomas A., additional, Ratan, Rajiv R., additional, Rimrodt, Sheryl L., additional, Rothstein, Jeffrey D., additional, Russell, James W., additional, Rutka, James T., additional, Saling, Michael M., additional, Scharfman, Helen E., additional, Schenck, Carlos H., additional, Schenone, Angelo, additional, Schrage, William G., additional, Schroeter, Michael, additional, Schütz, Peter W., additional, Simmons, Zachary, additional, Singer, Harvey S., additional, Singh, Ajay K., additional, Singleton, J.R., additional, Smith, A.G., additional, Carter Snead, O., additional, Sorenson, Eric J., additional, Srikanth, Velandai, additional, Stöckler, Sylvia, additional, Sumner, Charlotte J., additional, Swash, Michael, additional, Teener, James W., additional, Thornton, Charles A., additional, Thrift, Amanda G., additional, Töpfnerz, Nicole, additional, Tsuji, Shoji, additional, Turetz, Meredith L., additional, Twydell, Paul, additional, Vercueil, Laurent, additional, Vernino, Steven, additional, Vincent, Angela, additional, Volpe, Bruce T., additional, Wagner, Kenneth R., additional, Walkley, Steven U., additional, Weil, Robert J., additional, Weiss, William A., additional, Weksler, Babette B., additional, Wenning, Gregor K., additional, Westner, Ingo M., additional, Westphal, Manfred, additional, Wilkinson, Philip A., additional, Wong, Alice, additional, Xi, Guohua, additional, Zajac, Jeffrey D., additional, and Zeitzer, Jamie M., additional

Published
2007
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26. Editors

Author

Gilman, Sid, primary, Brust, John C.M., additional, Caronna, John J., additional, Casey, Kenneth L., additional, Feldman, Eva L., additional, Gomez, Christopher, additional, Johnson, Richard T., additional, Johnston, Michael V., additional, Laterra, John J., additional, Low, Phillip A., additional, Mazziotta, John C., additional, Mignot, Emmanuel, additional, Morgenstern, Lewis B., additional, Moser, Hugo W., additional, Pedley, Timothy A., additional, Reder, Anthony T., additional, Russell, James W., additional, Thornton, Charles A., additional, and Wenning, Gregor K., additional

Published
2007
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32. At Jeopardy: The NIH as We Know It

Author

Rosenberg, Roger N., Pedley, Timothy A., Baringer, J. Richard, Fahn, Stanley, Lisak, Robert P., Mayeux, Richard P., Olson, Sandra F., Ringel, Steven P., Rowland, Lewis P., and Selzer, Michael E.

Published
2003

34. Reporting clinical trials: full access to all the data

Author

Rosenberg, Roger N., Aminoff, Michael, Boller, Francois, Soerensen, Per Soelberg, Griggs, Robert C., Hachinski, Vladimir, Hallett, Mark, Johnson, Richard T., Kennard, Christopher, Lang, Anthony E., Lees, Andrew J., Lisak, Robert, Newsom-Davis, John, Pedley, Timothy A., Selzer, Michael E., and Zochodne, Douglas

Published
2002

36. Reporting Clinical Trials: Full Access to All of the Data

Author

Rosenberg, Roger N., Aminoff, Michael, Boller, François, Soerensen, Per Soelberg, Griggs, Robert C., Hachinski, Vladimir, Hallett, Mark, Johnson, Richard T., Kennard, Christopher, Lang, Anthony E., Lees, Andrew J., Lisak, Robert, Newsom-Davis, John, Pedley, Timothy A., Selzer, Michael E., and Zochodne, Douglas

Published
2002

37. The heart works against gravity

Author

Seymour, Roger S., Hargens, Alan R., and Pedley, Timothy J.

Subjects
Cardiology -- Research, Blood viscosity -- Analysis, Blood flow -- Analysis, Blood pressure -- Observations, Biological sciences
Abstract

Vertebrate animals have circulatory systems which are closed, and the movement of blood to and from the heart remains constant at a particular level. The siphon theory is seen in vascular loops above the heart, and it reveals the functioning of the heart against the vascular resistance of the system, rather than against gravity. The likely collapsible feature of descending vasculature reveals a lack of assistance to blood flow in superior vascular loops. Vascular collapse causes a stoppage in the blood flow.

Published
1993

42. The evaluation and treatment of seizures

Author

Scheuer, Mark L. and Pedley, Timothy A.

Subjects
Epilepsy -- Care and treatment, Anticonvulsants -- Evaluation, Epileptics -- Health aspects, Electroencephalography, Febrile convulsions -- Care and treatment
Published
1990

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