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16. I. Adrenal Cortex and Steroid 21-Hydroxylase Autoantibodies in Adult Patients with Organ-Specific Autoimmune Diseases: Markers of Low Progression to Clinical Addison’s Disease

Author

Betterle, Corrado, Volpato, M., REES SMITH, B., Furmaniak, J., Chen, S., Greggio, N. A., Sanzari, M., Tedesco, F., Pedini, B., Boscaro, Marco, and Presotto, F.

Subjects
Adult, Male, Endocrinology, Diabetes and Metabolism, Biochemistry (medical), Clinical Biochemistry, Middle Aged, Biochemistry, eye diseases, Autoimmune Diseases, stomatognathic diseases, Endocrinology, Addison Disease, Organ Specificity, Adrenal Cortex, Disease Progression, Humans, Female, Prospective Studies, Steroid 21-Hydroxylase, Biomarkers, Autoantibodies, Follow-Up Studies
Abstract

Adrenal cortex antibodies (ACA) were measured by immunofluorescence in 8840 adult patients with organ-specific autoimmune diseases without overt hypoadrenalism. Sixty-seven (0.8%) patients were ACA-positive, with the highest prevalence in those with premature ovarian failure (8.9%). Forty-eight ACA-positive and 20 ACA-negative individuals were enrolled into a prospective study. Antibodies to steroid 21-hydroxylase (21-OH), steroid 17α-hydroxylase (17α-OH) and cytochrome P450 side chain cleavage enzyme (P450scc) were measured by immunoprecipitation assay. Human leucocyte antigens D-related (HLA-DR) genotyping was also carried out and adrenal function assessed by ACTH test. On enrollment, 75% of ACA-positive patients had a normal adrenal function, while 25% revealed a subclinical hypoadrenalism. 21-OH antibodies were positive in 91% of ACA-positive sera. Eleven patients were positive for steroid-cell antibodies by immunofluorescence, and 9 revealed a positivity for antibodies to 17α-OH and/or P450scc. During the prospective study, overt Addison’s disease developed in 21% and subclinical hypoadrenalism in 29% of ACA-positive patients, while 50% maintained normal adrenal function. Progression to Addison’s disease was more frequent in patients with subclinical hypoadrenalism, high titers of ACA and higher levels of 21-OH antibodies, complement-fixing ACA and HLA-DR3 status. All 20 persistently ACA-negative patients were also negative for antibodies to 21-OH, 17α-OH, and P450scc, and all maintained normal adrenal function during follow-up. In conclusion, the detection of ACA/21-OH antibodies in adults is a marker of low progression toward clinical Addison’s disease. .

Published
1997
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20. Is hepatitis C virus a risk factor for thyroid autoimmunity?

Author

Floreani, Annarosa, Betterle, Corrado, Carderi, Isabella, Presotto, F, Pedini, B, Moscon, A, Andrea, O, Chiaramonte, M, and ARSITA ONE RESEARCH GROUP

Subjects
Adult, Male, endocrine system, endocrine system diseases, Hepatitis C virus, Population, Hepacivirus, medicine.disease_cause, Thyroid function tests, Statistics, Nonparametric, Sex Factors, Risk Factors, Seroepidemiologic Studies, Virology, medicine, Genetic predisposition, Humans, education, Autoantibodies, education.field_of_study, Hepatology, medicine.diagnostic_test, business.industry, Thyroid disease, Thyroid, Autoantibody, Age Factors, virus diseases, Hepatitis C Antibodies, Hepatitis C, Chronic, Middle Aged, medicine.disease, Thyroid Diseases, digestive system diseases, Anti-thyroid autoantibodies, Infectious Diseases, medicine.anatomical_structure, Italy, Immunology, Female, business
Abstract

Summary. The role of hepatitis C virus (HCV) in inducing thyroid autoimmunity is still under discussion and to assess the prevalence of thyroid autoantibodies and thyroid disease in the general population and to analyse the role of HCV in inducing thyroid autoimmunity. We studied 697 subjects residing in Arsita (a small town in central Italy). Thyroid autoantibodies and nonorgan-specific autoantibodies (NOSAs) were tested in each subject, who were also screened for anti-HCV antibodies; all subjects found positive to HCV–RNA were considered as being HCV-infected. Thyroid function tests were performed in all subjects positive for thyroid autoantibody. Seventy-one subjects were found HCV-positive; four of these (5.6%) were positive for at least one thyroid autoantibody, as opposed to 7 (4.9%) of the 142 sex- and age-matched controls of the same population (P = n.s.). Thyroid dysfunction was found in 2/4 HCV-positive, and in 1/7 HCV-negative subjects with thyroid autoantibodies (P = n.s.). NOSAs were significantly more common in HCV-positive than in HCV-negative subjects (P

Published
2006

21. Estimating the of autoimmune Addison's disease

Author

Coco, G., DAL PRA, Chiara, Prieur, ANNE MARIE, Albergoni, M. P., Canova, Cristina, Pedini, B., Chen, S., Furmaniak, J., REES SMITH, B., Mantero, Franco, and Betterle, Corrado

Published
2004

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