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1. Executive Summary of Recommendations and Expert Consensus for Plasma and Platelet Transfusion Practice in Critically Ill Children: From the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding (TAXI-CAB).

Author

Nellis, Marianne E, Karam, Oliver, Valentine, Stacey L, Bateman, Scot T, Remy, Kenneth E, Lacroix, Jacques, Cholette, Jill M, Bembea, Melania M, Russell, Robert T, Steiner, Marie E, Goobie, Susan M, Tucci, Marisa, Stricker, Paul A, Stanworth, Simon J, Delaney, Meghan, Lieberman, Lani, Muszynski, Jennifer A, Bauer, David F, Steffen, Katherine, Nishijima, Daniel, Ibla, Juan, Emani, Sitaram, Vogel, Adam M, Haas, Thorsten, Goel, Ruchika, Crighton, Gemma, Delgado, Diana, Demetres, Michelle, Parker, Robert I, and Pediatric Critical Care Transfusion and Anemia EXpertise Initiative—Control/Avoidance of Bleeding (TAXI-CAB), in collaboration with the Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network

Subjects
Pediatric Critical Care Transfusion and Anemia EXpertise Initiative—Control/Avoidance of Bleeding (TAXI-CAB), in collaboration with the Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network, Humans, Anemia, Critical Illness, Erythrocyte Transfusion, Platelet Transfusion, Critical Care, Evidence-Based Medicine, Child, Infant, Hematology, Pediatric, Clinical Research, Digestive Diseases, Blood, child, coagulopathy, critical illness, hemostasis, plasma, platelet transfusion, Nursing, Paediatrics and Reproductive Medicine, Pediatrics
Abstract

ObjectivesCritically ill children frequently receive plasma and platelet transfusions. We sought to determine evidence-based recommendations, and when evidence was insufficient, we developed expert-based consensus statements about decision-making for plasma and platelet transfusions in critically ill pediatric patients.DesignSystematic review and consensus conference series involving multidisciplinary international experts in hemostasis, and plasma/platelet transfusion in critically ill infants and children (Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding [TAXI-CAB]).SettingNot applicable.PatientsChildren admitted to a PICU at risk of bleeding and receipt of plasma and/or platelet transfusions.InterventionsNone.Measurements and main resultsA panel of 29 experts in methodology, transfusion, and implementation science from five countries and nine pediatric subspecialties completed a systematic review and participated in a virtual consensus conference series to develop recommendations. The search included MEDLINE, EMBASE, and Cochrane Library databases, from inception to December 2020, using a combination of subject heading terms and text words for concepts of plasma and platelet transfusion in critically ill children. Four graded recommendations and 49 consensus expert statements were developed using modified Research and Development/UCLA and Grading of Recommendations, Assessment, Development, and Evaluation methodology. We focused on eight subpopulations of critical illness (1, severe trauma, intracranial hemorrhage, or traumatic brain injury; 2, cardiopulmonary bypass surgery; 3, extracorporeal membrane oxygenation; 4, oncologic diagnosis or hematopoietic stem cell transplantation; 5, acute liver failure or liver transplantation; 6, noncardiac surgery; 7, invasive procedures outside the operating room; 8, sepsis and/or disseminated intravascular coagulation) as well as laboratory assays and selection/processing of plasma and platelet components. In total, we came to consensus on four recommendations, five good practice statements, and 44 consensus-based statements. These results were further developed into consensus-based clinical decision trees for plasma and platelet transfusion in critically ill pediatric patients.ConclusionsThe TAXI-CAB program provides expert-based consensus for pediatric intensivists for the administration of plasma and/or platelet transfusions in critically ill pediatric patients. There is a pressing need for primary research to provide more evidence to guide practitioners.

Published
2022

2. The age of blood in pediatric intensive care units (ABC PICU): study protocol for a randomized controlled trial

Author

Marisa Tucci, Jacques Lacroix, Dean Fergusson, Allan Doctor, Paul Hébert, Robert A. Berg, Jaime Caro, Cassandra D. Josephson, Stéphane Leteurtre, Kusum Menon, Kenneth Schechtman, Marie E. Steiner, Alexis F. Turgeon, Lucy Clayton, Tina Bockelmann, Philip C. Spinella, for the Canadian Critical Care Trials Group, the Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network

Subjects
Blood, Children, Critical care, Erythrocyte, Red blood cell (RBC), Intensive care, Medicine (General), R5-920
Abstract

Abstract Background The “Age of Blood in Children in Pediatric Intensive Care Unit” (ABC PICU) study is a randomized controlled trial (RCT) that aims to determine if red blood cell (RBC) unit storage age affects outcomes in critically ill children. While RBCs can be stored for up to 42 days in additive solutions, their efficacy and safety after long-term storage have been challenged. Preclinical and clinical observational evidence suggests loss of efficacy and lack of safety of older RBC units, especially in more vulnerable populations such as critically ill children. Because there is a belief that shorter storage will improve outcomes, some physicians and institutions systematically transfuse fresh RBCs to children. Conversely, the standard practice of blood banks is to deliver the oldest available RBC unit (first-in, first-out policy) in order to decrease wastage. Methods/design The ABC PICU study, is a double-blind superiority trial comparing the development of “New or Progressive Multiple Organ Dysfunction Syndrome” (NPMODS) in 1538 critically ill children randomized to either transfusion with RBCs stored for ≤ 7 days or to standard-issue RBCs (oldest in inventory). Patients are being recruited from 52 centers in the US, Canada, France, Italy, and Israel. Discussion The ABC PICU study should have significant implications for blood procurement services. A relative risk reduction of 33% is postulated in the short-storage arm. If a difference is found, this will indicate that fresher RBCs do improve outcomes in the pediatric intensive care unit population and would justify that use in critically ill children. If no difference is found, this will reassure clinicians and transfusion medicine specialists regarding the safety of the current system of allocating the oldest RBC unit in inventory and will discourage clinicians from preferentially requesting fresher blood for critically ill children. Trial registration ClinicalTrials.gov, ID: NCT01977547. Registered on 6 November 2013.

Published
2018
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3. Effect of red blood cell storage time in pediatric cardiac surgery patients: A subgroup analysis of a randomized controlled trial.

Author

Martin, Sophie, Tucci, Marisa, Spinella, Philip Charles, Ducruet, Thierry, Fergusson, Dean A, Freed, Darren H, Lacroix, Jacques, Poirier, Nancy, Sivarajan, Venkatesan VB, Steiner, Katharina Marie, Willems, Ariane, Garcia Guerra, Gonzalo, Age of Blood in Children in Pediatric Intensive Care Unit Trial Investigators, Canadian Critical Care Trials Group, Pediatric Acute Lung Injury and Sepsis Investigators Network, BloodNet Pediatric Critical Care Blood Research Network, Groupe Francophone de Réanimation et Urgences Pédiatriques, Martin, Sophie, Tucci, Marisa, Spinella, Philip Charles, Ducruet, Thierry, Fergusson, Dean A, Freed, Darren H, Lacroix, Jacques, Poirier, Nancy, Sivarajan, Venkatesan VB, Steiner, Katharina Marie, Willems, Ariane, Garcia Guerra, Gonzalo, Age of Blood in Children in Pediatric Intensive Care Unit Trial Investigators, Canadian Critical Care Trials Group, Pediatric Acute Lung Injury and Sepsis Investigators Network, BloodNet Pediatric Critical Care Blood Research Network, and Groupe Francophone de Réanimation et Urgences Pédiatriques

Abstract

This study aimed to determine whether or not transfusion of fresh red blood cells (RBCs) reduced the incidence of new or progressive multiple organ dysfunction syndrome compared with standard-issue RBCs in pediatric patients undergoing cardiac surgery., info:eu-repo/semantics/published

Published
2023

4. The age of blood in pediatric intensive care units (ABC PICU): study protocol for a randomized controlled trial

Author

Tucci, Marisa, Lacroix, Jacques, Fergusson, Dean, Doctor, Allan, Hébert, Paul, Berg, Robert A., Caro, Jaime, Josephson, Cassandra D., Leteurtre, Stéphane, Menon, Kusum, Schechtman, Kenneth, Steiner, Marie E., Turgeon, Alexis F., Clayton, Lucy, Bockelmann, Tina, Spinella, Philip C., for the Canadian Critical Care Trials Group, the Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network

Published
2018
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5. Plasma and Platelet Transfusion Strategies in Critically Ill Children Following Severe Trauma, Traumatic Brain Injury, and/or Intracranial Hemorrhage: From the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding.

Author

Russell, Robert, Russell, Robert, Bauer, David F, Goobie, Susan M, Haas, Thorsten, Nellis, Marianne E, Nishijima, Daniel K, Vogel, Adam M, Lacroix, Jacques, Transfusion and Anemia EXpertise Initiative–Control/Avoidance of Bleeding (TAXI-CAB), the Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network, Russell, Robert, Russell, Robert, Bauer, David F, Goobie, Susan M, Haas, Thorsten, Nellis, Marianne E, Nishijima, Daniel K, Vogel, Adam M, Lacroix, Jacques, and Transfusion and Anemia EXpertise Initiative–Control/Avoidance of Bleeding (TAXI-CAB), the Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network

Abstract

ObjectivesTo present consensus statements and supporting literature for plasma and platelet transfusions in critically ill children with severe trauma, traumatic brain injury, and/or intracranial hemorrhage from the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding.DesignSystematic review and consensus conference of international, multidisciplinary experts in platelet and plasma transfusion management of critically ill children.SettingNot applicable.PatientsCritically ill neonates and children with severe trauma, traumatic brain injury, and/or intracranial hemorrhage.InterventionsNone.Measurements and main resultsA panel of eight experts developed expert-based statements for plasma and platelet transfusions in critically ill neonates and children with severe trauma, traumatic brain injury, and/or intracranial hemorrhage. These statements were reviewed and ratified by the 29 Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding experts. A systematic review was conducted using MEDLINE, EMBASE, and Cochrane Library databases, from inception to December 2020. Consensus was obtained using the Research and Development/University of California, Los Angeles Appropriateness Method. Results were summarized using the Grading of Recommendations Assessment, Development, and Evaluation method. We developed one good practice statement and six expert consensus statements.ConclusionsThe lack of evidence precludes proposing recommendations on monitoring of the coagulation system and on plasma and platelets transfusion in critically ill pediatric patients with severe trauma, severe traumatic brain injury, or nontraumatic intracranial hemorrhage.

Published
2022

6. How 217 Pediatric Intensivists Manage Anemia at PICU Discharge: Online Responses to an International Survey.

Author

Demaret, Pierre, Karam, Oliver, Labreuche Bst, Julien, Chiusolo, Fabrizio, Mayordomo Colunga, Juan, Erickson, Simon, Nellis, Marianne E, Perez, Marie-Hélène, Ray, Samiran, Tucci, Marisa, Willems, Ariane, Duhamel, Alain, Lebrun, Frédéric, Loeckx, Isabelle, Mulder, André, Leteurtre, Stéphane, Groupe Francophone de Réanimation et d’Urgences Pédiatriques (GFRUP); the Pediatric Critical Care Blood Research Network (BloodNet); and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network, Demaret, Pierre, Karam, Oliver, Labreuche Bst, Julien, Chiusolo, Fabrizio, Mayordomo Colunga, Juan, Erickson, Simon, Nellis, Marianne E, Perez, Marie-Hélène, Ray, Samiran, Tucci, Marisa, Willems, Ariane, Duhamel, Alain, Lebrun, Frédéric, Loeckx, Isabelle, Mulder, André, Leteurtre, Stéphane, and Groupe Francophone de Réanimation et d’Urgences Pédiatriques (GFRUP); the Pediatric Critical Care Blood Research Network (BloodNet); and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network

Abstract

To describe the management of anemia at PICU discharge by pediatric intensivists., info:eu-repo/semantics/published

Published
2020

7. Effects of ABO Matching of Platelet Transfusions in Critically Ill Children.

Author

Nellis, Marianne E, Nellis, Marianne E, Goel, Ruchika, Karam, Oliver, Cushing, Melissa M, Davis, Peter J, Steiner, Marie E, Tucci, Marisa, Stanworth, Simon J, Spinella, Philip C, Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network, Pediatric Critical Care Blood Research Network (BloodNet), and the P3T Investigators, P3T Investigators, Nellis, Marianne E, Nellis, Marianne E, Goel, Ruchika, Karam, Oliver, Cushing, Melissa M, Davis, Peter J, Steiner, Marie E, Tucci, Marisa, Stanworth, Simon J, Spinella, Philip C, Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network, Pediatric Critical Care Blood Research Network (BloodNet), and the P3T Investigators, and P3T Investigators

Abstract

ObjectivesTo determine if transfusing ABO compatible platelets has a greater effect on incremental change in platelet count as compared to ABO incompatible platelets in critically ill children.DesignSecondary analysis of a prospective, observational study. Transfusions were classified as either ABO compatible, major incompatibility, or minor incompatibility. The primary outcome was the incremental change in platelet count. Transfusion reactions were analyzed as a secondary outcome.SettingEighty-two PICUs in 16 countries.PatientsChildren (3 d to 16 yr old) were enrolled if they received a platelet transfusion during one of the predefined screening weeks.InterventionsNone.Measurements and main resultsFive-hundred three children were enrolled and had complete ABO information for both donor and recipient, as well as laboratory data. Three-hundred forty-two (68%) received ABO-identical platelets, 133 (26%) received platelets with major incompatibility, and 28 (6%) received platelets with minor incompatibility. Age, weight, proportion with mechanical ventilation or underlying oncologic diagnosis did not differ between the groups. After adjustment for transfusion dose, there was no difference in the incremental change in platelet count between the groups; the median (interquartile range) change for ABO-identical transfusions was 28 × 10 cells/L (8-68 × 10 cells/L), for transfusions with major incompatibility 26 × 10 cells/L (7-74 × 10 cells/L), and for transfusions with minor incompatibility 54 × 10 cells/L (14-81 × 10 cells/L) (p = 0.37). No differences in count increment between the groups were noted for bleeding (p = 0.92) and nonbleeding patients (p = 0.29). There were also no differences observed between the groups for any transfusion reaction (p = 0.07).ConclusionsNo differences were seen in the incremental change in platelet count nor in transfusion reactions when comparing major ABO incompatible platelet transfusions with ABO compatible transfusions in a large stud

Published
2019

8. Bleeding Assessment Scale in Critically Ill Children (BASIC): Physician-Driven Diagnostic Criteria for Bleeding Severity.

Author

Nellis, Marianne E, Tucci, Marisa, Lacroix, Jacques, Spinella, Philip Charles, Haque, Kelly KD, Stock, Arabela, Steiner, Katharina Marie, Faustino, Vincent EVS, Zantek, Nicole ND, Davis, Peter J, Stanworth, Simon J, Cholette, Jill J.M., Parker, Robert I, Demaret, Pierre, Kneyber, Martin MCJ, Russell, Robert T, Stricker, Paul PA, Vogel, Adam M, Willems, Ariane, Josephson, Cassandra CD, Luban, Naomi L C, Loftis, Laura LL, Leteurtre, Stéphane, Stocker, Christian CF, Goobie, Susan M, Karam, Oliver, Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network; and the Pediatric Critical Care Blood Research Network (BloodNet), Nellis, Marianne E, Tucci, Marisa, Lacroix, Jacques, Spinella, Philip Charles, Haque, Kelly KD, Stock, Arabela, Steiner, Katharina Marie, Faustino, Vincent EVS, Zantek, Nicole ND, Davis, Peter J, Stanworth, Simon J, Cholette, Jill J.M., Parker, Robert I, Demaret, Pierre, Kneyber, Martin MCJ, Russell, Robert T, Stricker, Paul PA, Vogel, Adam M, Willems, Ariane, Josephson, Cassandra CD, Luban, Naomi L C, Loftis, Laura LL, Leteurtre, Stéphane, Stocker, Christian CF, Goobie, Susan M, Karam, Oliver, and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network; and the Pediatric Critical Care Blood Research Network (BloodNet)

Abstract

Although bleeding frequently occurs in critical illness, no published definition to date describes the severity of bleeding accurately in critically ill children. We sought to develop diagnostic criteria for bleeding severity in critically ill children., info:eu-repo/semantics/published

Published
2019

9. The age of blood in pediatric intensive care units (abc picu):study protocol for a randomized controlled trial

Author

Marisa Tucci, Jacques Lacroix, Dean Fergusson, Allan Doctor, Paul Hébert, Robert A. Berg, Jaime Caro, Cassandra D. Josephson, Stéphane Leteurtre, Kusum Menon, Kenneth Schechtman, Marie E. Steiner, Alexis F. Turgeon, Lucy Clayton, Tina Bockelmann, Philip C. Spinella, for the Canadian Critical Care Trials Group, the Pediatric Critical Care Blood Research Network (BloodNet), the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network, CHU Lille, Université de Lille, METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694, CHU Sainte Justine [Montréal], University of Ottawa [Ottawa], The Ottawa Hospital, Hospital of the University of Pennsylvania [HUP], Centers for Disease Control and Prevention [Atlanta] [CDC], Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS], University of Minnesota Medical School, Faculté de médecine de l'Université Laval [Québec] [ULaval], Université de Montréal (UdeM), Washington University in Saint Louis (WUSTL), Hospital of the University of Pennsylvania (HUP), Perelman School of Medicine, University of Pennsylvania [Philadelphia]-University of Pennsylvania [Philadelphia], Centers for Disease Control and Prevention [Atlanta] (CDC), Centers for Disease Control and Prevention, Evaluation des technologies de santé et des pratiques médicales - ULR 2694 (METRICS), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Université de Lille, University of Minnesota System, Faculté de médecine de l'Université Laval [Québec] (ULaval), University of Ottawa [Ottawa] (uOttawa), Washington University in St Louis, Santé publique : épidémiologie et qualité des soins-EA 2694 (CERIM), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), University of Pennsylvania-University of Pennsylvania, and Université Laval [Québec] (ULaval)

Subjects
Relative risk reduction, Male, Time Factors, [SDV]Life Sciences [q-bio], Medicine (miscellaneous), 030204 cardiovascular system & hematology, law.invention, 0302 clinical medicine, Superiority Trial, Randomized controlled trial, law, Risk Factors, Multicenter Studies as Topic, Pharmacology (medical), 030212 general & internal medicine, Hospital Mortality, Israel, Child, Children, Randomized Controlled Trials as Topic, Pediatric intensive care unit, lcsh:R5-920, education.field_of_study, Transfusion medicine, 3. Good health, Europe, Erythrocyte, Treatment Outcome, Blood, Child, Preschool, Female, lcsh:Medicine (General), Erythrocyte Transfusion, medicine.medical_specialty, Canada, Adolescent, Critical Illness, Multiple Organ Failure, Population, Intensive Care Units, Pediatric, Risk Assessment, 03 medical and health sciences, Double-Blind Method, Intensive care, Study protocol, medicine, Humans, Mortality, education, Critical care, Transfusion, Red blood cell (RBC), business.industry, Infant, Newborn, Infant, medicine.disease, United States, Blood Preservation, Emergency medicine, business, Multiple organ dysfunction syndrome
Abstract

Background The “Age of Blood in Children in Pediatric Intensive Care Unit” (ABC PICU) study is a randomized controlled trial (RCT) that aims to determine if red blood cell (RBC) unit storage age affects outcomes in critically ill children. While RBCs can be stored for up to 42 days in additive solutions, their efficacy and safety after long-term storage have been challenged. Preclinical and clinical observational evidence suggests loss of efficacy and lack of safety of older RBC units, especially in more vulnerable populations such as critically ill children. Because there is a belief that shorter storage will improve outcomes, some physicians and institutions systematically transfuse fresh RBCs to children. Conversely, the standard practice of blood banks is to deliver the oldest available RBC unit (first-in, first-out policy) in order to decrease wastage. Methods/design The ABC PICU study, is a double-blind superiority trial comparing the development of “New or Progressive Multiple Organ Dysfunction Syndrome” (NPMODS) in 1538 critically ill children randomized to either transfusion with RBCs stored for ≤ 7 days or to standard-issue RBCs (oldest in inventory). Patients are being recruited from 52 centers in the US, Canada, France, Italy, and Israel. Discussion The ABC PICU study should have significant implications for blood procurement services. A relative risk reduction of 33% is postulated in the short-storage arm. If a difference is found, this will indicate that fresher RBCs do improve outcomes in the pediatric intensive care unit population and would justify that use in critically ill children. If no difference is found, this will reassure clinicians and transfusion medicine specialists regarding the safety of the current system of allocating the oldest RBC unit in inventory and will discourage clinicians from preferentially requesting fresher blood for critically ill children. Trial registration ClinicalTrials.gov, ID: NCT01977547. Registered on 6 November 2013. Electronic supplementary material The online version of this article (10.1186/s13063-018-2809-y) contains supplementary material, which is available to authorized users.

Published
2018

10. Mechanisms of red blood cell transfusion-related immunomodulation

Author

Remy, Kenneth E, Hall, Mark W, Cholette, Jill, Juffermans, Nicole P, Nicol, Kathleen, Doctor, Allan, Blumberg, Neil, Spinella, Philip C, Norris, Philip J, Dahmer, Mary K, Muszynski, Jennifer A, and Pediatric Critical Care Blood Research Network (Blood Net)

Subjects
Inflammation, Clinical Sciences, Immunology, Hematology, Cardiorespiratory Medicine and Haematology, Blood, Cardiovascular System & Hematology, Clinical Research, Pediatric Critical Care Blood Research Network, Immune Tolerance, Animals, Humans, Immunologic Factors, 2.1 Biological and endogenous factors, Aetiology, Erythrocyte Transfusion
Abstract

Red blood cell (RBC) transfusion is common in critically ill, postsurgical, and posttrauma patients in whom both systemic inflammation and immune suppression are associated with adverse outcomes. RBC products contain a multitude of immunomodulatory mediators that interact with and alter immune cell function. These interactions can lead to both proinflammatory and immunosuppressive effects. Defining clinical outcomes related to immunomodulatory effects of RBCs in transfused patients remains a challenge, likely due to complex interactions between individual blood product characteristics and patient-specific risk factors. Unpacking these complexities requires an in-depth understanding of the mechanisms of immunomodulatory effects of RBC products. In this review, we outline and classify potential mediators of RBC transfusion-related immunomodulation and provide suggestions for future research directions.

Published
2018

11. Efficacy of Early Prophylaxis Against Catheter-Associated Thrombosis in Critically Ill Children: A Bayesian Phase 2b Randomized Clinical Trial.

Author

Faustino, E. Vincent S., Shabanova, Veronika, Raffini, Leslie J., Kandil, Sarah B., Li, Simon, Pinto, Matthew G., Cholette, Jill M., Hanson, Sheila J., Nellis, Marianne E., Silva, Cicero T., Chima, Ranjit, Sharathkumar, Anjali, Thomas, Kimberly A., McPartland, Tara, Tala, Joana A., Spinella, Philip C., and CRETE Trial Investigators and the Pediatric Critical Care Blood Research Network (BloodNet) of the Pediatric Acute Lung Injury and Sepsis Investigators Network (PALISI)

Published
2021
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12. Effect of platelet storage duration on clinical outcomes and incremental platelet change in critically ill children.

Author

Nellis, Marianne E., Spinella, Philip C., Tucci, Marisa, Stanworth, Simon J., Steiner, Marie E., Cushing, Melissa M., Davis, Peter J., Karam, Oliver, and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) network, Pediatric Critical Care Blood Research Network (BloodNet), and the P3T Investigators†

Subjects
CRITICALLY ill children, PEDIATRIC intensive care, INTENSIVE care units, BLOOD collection, BLOOD platelets, HEMORRHAGE prevention, RESEARCH, TIME, RESEARCH methodology, BLOOD transfusion reaction, PEDIATRICS, MEDICAL cooperation, EVALUATION research, CATASTROPHIC illness, COMPARATIVE studies, BLOOD platelet transfusion, RESEARCH funding, LONGITUDINAL method, HEMORRHAGE
Abstract

The safety of platelet (PLT) concentrates with longer storage duration has been questioned due to biochemical and functional changes that occur during blood collection and storage. Some studies have suggested that transfusion efficacy is decreased and immune system dysfunction is worsened with increased storage age. We sought to describe the effect of PLT storage age on laboratory and clinical outcomes in critically ill children receiving PLT transfusions.Study Design and Methods: We performed a secondary analysis of a prospective, observational point-prevalence study. Children (3 days to 16 years of age) from 82 pediatric intensive care units in 16 countries were enrolled if they received a PLT transfusion during one of the predefined screening weeks. Outcomes (including PLT count increments, organ dysfunction, and transfusion reactions) were evaluated by PLT storage age.Results: Data from 497 patients were analyzed. The age of the PLT transfusions ranged from 1 to 7 days but the majority were 4 (24%) or 5 (36%) days of age. Nearly two-thirds of PLT concentrates were transfused to prevent bleeding. The indication for transfusion did not differ between storage age groups (P = .610). After patient and product variables were adjusted for, there was no association between storage age and incremental change in total PLT count or organ dysfunction scoring. A significant association between fresher storage age and febrile transfusion reactions (P = .002) was observed.Conclusion: The results in a large, diverse cohort of critically ill children raise questions about the impact of storage age on transfusion and clinical outcomes which require further prospective evaluation. [ABSTRACT FROM AUTHOR]

Published
2020
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13. Outcomes Related to the Use of Frozen Plasma or Pooled Solvent/Detergent-Treated Plasma in Critically Ill Children

Author

Camazine, Maraya N, Karam, Oliver, Colvin, Ryan, Leteurtre, Stephane, Demaret, Pierre, Tucci, Marisa, Muszynski, Jennifer A, Stanworth, Simon, Spinella, Philip C, PlasmaTV investigators, Pediatric Critical Care Blood Research Network, University of Zurich, and Spinella, Philip C

Subjects
10036 Medical Clinic, 610 Medicine & health, 2735 Pediatrics, Perinatology and Child Health, 2706 Critical Care and Intensive Care Medicine
Published
2017

14. Transfusion-related immunomodulation: review of the literature and implications for pediatric critical illness

Author

Muszynski, Jennifer A, Spinella, Philip C, Cholette, Jill M, Acker, Jason P, Hall, Mark W, Juffermans, Nicole P, Kelly, Daniel P, Blumberg, Neil, Nicol, Kathleen, Liedel, Jennifer, Doctor, Allan, Remy, Kenneth E, Tucci, Marisa, Lacroix, Jacques, Norris, Philip J, and Pediatric Critical Care Blood Research Network (Blood Net)

Subjects
Inflammation, Adult, Male, Pediatric, Adolescent, Critical Illness, Clinical Sciences, Immunology, Infant, Blood Component Transfusion, Cardiorespiratory Medicine and Haematology, Immunomodulation, Intensive Care Units, Rare Diseases, Cardiovascular System & Hematology, Acute Disease, Pediatric Critical Care Blood Research Network, Humans, 2.1 Biological and endogenous factors, Female, Aetiology, Child, Preschool
Abstract

Transfusion-related immunomodulation (TRIM) in the intensive care unit (ICU) is difficult to define and likely represents a complicated set of physiologic responses to transfusion, including both proinflammatory and immunosuppressive effects. Similarly, the immunologic response to critical illness in both adults and children is highly complex and is characterized by both acute inflammation and acquired immune suppression. How transfusion may contribute to or perpetuate these phenotypes in the ICU is poorly understood, despite the fact that transfusion is common in critically ill patients. Both hyperinflammation and severe immune suppression are associated with poor outcomes from critical illness, underscoring the need to understand potential immunologic consequences of blood product transfusion. In this review we outline the dynamic immunologic response to critical illness, provide clinical evidence in support of immunomodulatory effects of blood product transfusion, review preclinical and translational studies to date of TRIM, and provide insight into future research directions.

Published
2017

15. Pediatric Plasma and Platelet Transfusions on Extracorporeal Membrane Oxygenation: A Subgroup Analysis of Two Large International Point-Prevalence Studies and the Role of Local Guidelines.

Author

Nellis, Marianne E., Saini, Arun, Spinella, Philip C., Davis, Peter J., Steiner, Marie E., Tucci, Marisa, Cushing, Melissa, Demaret, Pierre, Stanworth, Simon J., Leteurtre, Stephane, Karam, Oliver, and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network, Pediatric Critical Care Blood Research Network (BloodNet), and the PlasmaTV Investigators and the P3T Investigators

Published
2020
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16. Mechanisms of red blood cell transfusion-related immunomodulation.

Author

Remy, Kenneth E., Hall, Mark W., Cholette, Jill, Juffermans, Nicole P., Nicol, Kathleen, Doctor, Allan, Blumberg, Neil, Spinella, Philip C., Norris, Philip J., Dahmer, Mary K., Muszynski, Jennifer A., for the Pediatric Critical Care Blood Research Network (Blood Net), and Pediatric Critical Care Blood Research Network (Blood Net)

Subjects
RED blood cell transfusion, IMMUNOREGULATION, IMMUNOSUPPRESSION, INFLAMMATORY mediators, IMMUNOSUPPRESSIVE agents, ERYTHROCYTES, BLOOD transfusion reaction, IMMUNOLOGICAL adjuvants, INFLAMMATION
Abstract

Red blood cell (RBC) transfusion is common in critically ill, postsurgical, and posttrauma patients in whom both systemic inflammation and immune suppression are associated with adverse outcomes. RBC products contain a multitude of immunomodulatory mediators that interact with and alter immune cell function. These interactions can lead to both proinflammatory and immunosuppressive effects. Defining clinical outcomes related to immunomodulatory effects of RBCs in transfused patients remains a challenge, likely due to complex interactions between individual blood product characteristics and patient-specific risk factors. Unpacking these complexities requires an in-depth understanding of the mechanisms of immunomodulatory effects of RBC products. In this review, we outline and classify potential mediators of RBC transfusion-related immunomodulation and provide suggestions for future research directions. [ABSTRACT FROM AUTHOR]

Published
2018
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17. International Study of the Epidemiology of Platelet Transfusions in Critically Ill Children With an Underlying Oncologic Diagnosis.

Author

Nellis, Marianne E., Goel, Ruchika, Karam, Oliver, Cushing, Melissa M., Davis, Peter J., Steiner, Marie E., Tucci, Marisa, Stanworth, Simon J., Spinella, Philip C., and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network, Pediatric Critical Care Blood Research Network (BloodNet), and the Point Prevalence Study of Platelet Transfusions in Critically Ill Children (P3T) Investigators

Published
2019
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18. Effects of ABO Matching of Platelet Transfusions in Critically Ill Children.

Author

Nellis, Marianne E., Goel, Ruchika, Karam, Oliver, Cushing, Melissa M., Davis, Peter J., Steiner, Marie E., Tucci, Marisa, Stanworth, Simon J., Spinella, Philip C., Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network, Pediatric Critical Care Blood Research Network (BloodNet), and the P3T Investigators, and P3T Investigators

Published
2019
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19. Implementation of the Recommendations for RBC Transfusions for Critically Ill Children From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative.

Author

Steffen, Katherine M., Bateman, Scot T., Valentine, Stacey L., Small, Sara, Spinella, Philip C., Doctor, Allan, Pediatric Critical Care Transfusion and Anemia Expertise Initiative (TAXI), and Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network

Published
2018
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20. Recommendations on the Indications for RBC Transfusion for the Critically Ill Child Receiving Support From Extracorporeal Membrane Oxygenation, Ventricular Assist, and Renal Replacement Therapy Devices From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative.

Author

Bembea, Melania M., Cheifetz, Ira M., Fortenberry, James D., Bunchman, Timothy E., Valentine, Stacey L., Bateman, Scot T., Steiner, Marie E., Pediatric Critical Care Transfusion and Anemia Expertise Initiative (TAXI), and Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network

Published
2018
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21. Recommendations on Selection and Processing of RBC Components for Pediatric Patients From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative.

Author

Zantek, Nicole D., Parker, Robert I., van de Watering, Leo M., Josephson, Cassandra D., Bateman, Scot T., Valentine, Stacey L., Delaney, Meghan, Pediatric Critical Care Transfusion and Anemia Expertise Initiative (TAXI), and Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network

Published
2018
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22. Recommendations on RBC Transfusion Support in Children With Hematologic and Oncologic Diagnoses From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative.

Author

Steiner, Marie E., Zantek, Nicole D., Stanworth, Simon J., Parker, Robert I., Valentine, Stacey L., Lehmann, Leslie E., Josephson, Cassandra D., Bateman, Scot T., Luban, Naomi L. C., Pediatric Critical Care Transfusion and Anemia Expertise Initiative (TAXI), and Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network

Published
2018
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23. Recommendations on RBC Transfusion in Infants and Children With Acquired and Congenital Heart Disease From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative.

Author

Cholette, Jill M., Willems, Ariane, Valentine, Stacey L., Bateman, Scot T., Schwartz, Steven M., Pediatric Critical Care Transfusion and Anemia Expertise Initiative (TAXI), and Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network

Published
2018
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25. Recommendations on RBC Transfusion in Critically Ill Children With Nonlife-Threatening Bleeding or Hemorrhagic Shock From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative.

Author

Karam, Oliver, Russel, Robert T., Stricker, Paul, Vogel, Adam M., Bateman, Scot T., Valentine, Stacey L., Spinella, Philip C., Russell, Robert T, Pediatric Critical Care Transfusion and Anemia Expertise Initiative (TAXI), and Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network

Published
2018
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26. Recommendations on RBC Transfusions for Critically Ill Children With Nonhemorrhagic Shock From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative.

Author

Muszynski, Jennifer A., Guzzetta, Nina A., Hall, Mark W., Macrae, Duncan, Valentine, Stacey L., Bateman, Scot T., Spinella, Philip C., Pediatric Critical Care Transfusion and Anemia Expertise Initiative (TAXI), and Pediatric Critical Care Blood Research Network (Blood Net), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network

Published
2018
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27. Recommendations on RBC Transfusions in Critically Ill Children With Acute Respiratory Failure From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative.

Author

Demaret, Pierre, Emeriaud, Guillaume, Hassan, Nabil E., Kneyber, Martin C. J., Valentine, Stacey L., Bateman, Scot T., Tucci, Marisa, Pediatric Critical Care Transfusion and Anemia Expertise Initiative (TAXI), and Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network

Published
2018
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28. Recommendations on RBC Transfusion in General Critically Ill Children Based on Hemoglobin and/or Physiologic Thresholds From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative.

Author

Doctor, Allan, Cholette, Jill M., Remy, Kenneth E., Argent, Andrew, Carson, Jeffrey L., Valentine, Stacey L., Bateman, Scot T., Lacroix, Jacques, Pediatric Critical Care Transfusion and Anemia Expertise Initiative (TAXI), and Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network

Published
2018
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29. The Pediatric Critical Care Transfusion and Anemia Expertise Initiative Consensus Conference Methodology.

Author

Bembea, Melania M., Valentine, Stacey L., Bateman, Scot T., Wilson, Lisa M., Anton, Blair, Harger, Nancy, Robinson, Karen A., Pediatric Critical Care Transfusion and Anemia Expertise Initiative (TAXI), and Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network

Published
2018
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30. Platelet Transfusion Practices in Critically Ill Children.

Author

Nellis, Marianne E, Karam, Oliver, Mauer, Elizabeth, Cushing, Melissa M, Davis, Peter J, Steiner, Marie E, Tucci, Marisa, Stanworth, Simon J, Spinella, Philip C, and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) network, Pediatric Critical Care Blood Research Network (BloodNet), and the P3T Investigators

Published
2018
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32. Transfusion-related immunomodulation: review of the literature and implications for pediatric critical illness.

Author

Muszynski, Jennifer A., Spinella, Philip C., Cholette, Jill M., Acker, Jason P., Hall, Mark W., Juffermans, Nicole P., Kelly, Daniel P., Blumberg, Neil, Nicol, Kathleen, Liedel, Jennifer, Doctor, Allan, Remy, Kenneth E., Tucci, Marisa, Lacroix, Jacques, Norris, Philip J., and Pediatric Critical Care Blood Research Network (Blood Net)

Subjects
BLOOD transfusion, IMMUNOREGULATION, IMMUNOMODULATORS, PEDIATRIC intensive care, CRITICAL care medicine
Abstract

Transfusion-related immunomodulation (TRIM) in the intensive care unit (ICU) is difficult to define and likely represents a complicated set of physiologic responses to transfusion, including both proinflammatory and immunosuppressive effects. Similarly, the immunologic response to critical illness in both adults and children is highly complex and is characterized by both acute inflammation and acquired immune suppression. How transfusion may contribute to or perpetuate these phenotypes in the ICU is poorly understood, despite the fact that transfusion is common in critically ill patients. Both hyperinflammation and severe immune suppression are associated with poor outcomes from critical illness, underscoring the need to understand potential immunologic consequences of blood product transfusion. In this review we outline the dynamic immunologic response to critical illness, provide clinical evidence in support of immunomodulatory effects of blood product transfusion, review preclinical and translational studies to date of TRIM, and provide insight into future research directions. [ABSTRACT FROM AUTHOR]

Published
2017
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