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109 results on '"Pedersen, Ole F."'

4. Diagnosis of COPD

Author

Falaschetti, Emanuela, Swanney, Maureen P, Crapo, Robert O, Hankinson, John L, Jensen, Robert L, Pedersen, Ole F, Quanjer, Philip H, Ruppel, Gregg L, and Schouten, Jan P

Published
2007

12. A new staging strategy for chronic obstructive pulmonary disease

Author

Miller, Martin R, Pedersen, Ole F, and Dirksen, Asger

Subjects
Male, Models, Statistical, respiratory function tests, Denmark, spirometry, respiratory system, Middle Aged, Severity of Illness Index, respiratory tract diseases, chronic obstructive pulmonary disease, Pulmonary Disease, Chronic Obstructive, Forced Expiratory Volume, Humans, Female, circulatory and respiratory physiology, Original Research, Aged
Abstract

Background: The best method for expressing lung function impairment is undecided. We tested in a population of patients with chronic obstructive pulmonary disease (COPD) whether forced expiratory volume in 1 second (FEV1) or FEV1 divided by height squared (FEV1/ht2) was better than FEV1 percent predicted (FEV1PP) for predicting survival. Method: FEV1, FEV1PP, and FEV1/ht2 recorded post bronchodilator were compared as predictors of survival in 1095 COPD patients followed for 15 years. A staging system for severity of COPD was defined from FEV1/ht2 and compared with the Global Initiative for Obstructive Lung Disease (GOLD) staging system. Result: FEV1/ht2 was a better univariate predictor of survival in COPD than FEV1 and both were better than FEV1PP. The best multivariate model for predicting survival included FEV1/ht2, age and sex. Comparing the GOLD stages with the FEV1/ht2 groups found that survival was more coherent within each FEV1/ht group than it was within each GOLD stage. FEV1/ht2 had 60% more people in its most severe group than the severest GOLD stage with these extra subjects having equivalently poor survival and had 155% more in the least severe group with equivalent survival. GOLD staging misclassified 51% of subjects with regard to survival. Conclusion: We conclude that GOLD criteria using FEV1PP do not optimally stage COPD with regard to survival. An alternative strategy using FEV1/ht2 improves the staging of this disease. Studies which stratify COPD patients to determine the effect of interventions such as drug trials, rehabilitation, or management guidelines should consider alternatives to the GOLD classification.

Published
2007

44. Turbinate Hypertrophy: Evaluation of the Nasal Cavity by Acoustic Rhinometry

Author

Hilberg, Ole, Grymer, Luisa F., Pedersen, Ole F., and Elbrønd, Ole

Abstract

• We used acoustic rhinometry to assess the geometry of the nasal cavity. The cross-sectional area of the nasal cavity as a function of distance from the nostrils was obtained. Seventeen patients with hypertrophy of the inferior turbinate and septal deviations were examined preoperatively and postoperatively; 34 normal subjects served as controls. The cross-sectional area at the anterior part of the nose suggested that skeletal hypertrophy of the inferior turbinate might be expected in the side opposite the main septal deviation. Unilateral inferior turbinoplasty seems advisable.(Arch Otolaryngol Head Neck Surg. 1990;116:283-289)

Published
1990
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45. Is FEV1 determined in a plethysmograph a better indication of obstructive lung disease than FEV1 determined by a spirometer?

Author

Pedersen, Ole F.

Subjects
EXPIRATORY flow, RESPIRATORY measurements, OBSTRUCTIVE lung diseases, PULMONARY emphysema, CHRONIC bronchitis
Abstract

The article discusses research done on forced expiratory volume (FEV) and chronic obstructive pulmonary disease. It references the study "Severity Grading of Chronic Obstructive Pulmonary Disease: The Confounding Effect of Phenotype and Thoracic Gas Compression" by R. Pellegrino and colleagues published in the 2014 issue. It was found that FEV is more decreased in subjects with dominant emphysema than in those with chronic bronchitis.

Published
2015
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47. Best lung function equations for the very elderly selected by survival analysis.

Author

Miller MR, Thinggaard M, Christensen K, Pedersen OF, and Sigsgaard T

Subjects
Aged, Aged, 80 and over, Cohort Studies, Denmark, Female, Forced Expiratory Volume, Humans, Lung physiopathology, Male, Nutrition Surveys, Proportional Hazards Models, Respiratory Function Tests, Spirometry, Treatment Outcome, Kaplan-Meier Estimate, Lung physiology
Abstract

We evaluated which equations best predicted the lung function of a cohort of nonagenarians based on which best accounted for subsequent survival. In 1998, we measured lung function, grip strength and dementia score (Mini Mental State Examination (MMSE)) in a population-based sample of 2262 Danes born in 1905. Mortality was registered to 2011 when only five (0.2%) subjects were alive. In half the cohort, we recorded forced expiratory volume in 1 s (FEV1). Complete data were available in 592 subjects with results expressed as standardised residuals (SR) using various prediction equations. Cox proportional hazard regression found lower FEV1SR was a predictor of mortality having controlled for MMSE, grip strength and sex. The US National Health and Nutrition Examination Survey (NHANES) III (1999) equations gave a better spread of median survival by FEV1SR quartile: 3.94, 3.65, 3.51 and 2.61 years with a hazard ratio for death of 1, 1.16, 1.32 and 1.60 respectively, compared with equations derived with the inclusion of elderly subjects. We conclude that extrapolating from NHANES III equations to predict lung function in nonagenarians gave better survival predictions from spirometry than when employing equations derived using very elderly subjects with possible selection bias. These findings can help inform how future lung function equations for the elderly are derived.

Published
2014
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