Search

Your search keyword '"Pedersen, Mikkel W."' showing total 222 results
Start Over Author "Pedersen, Mikkel W."
222 results on '"Pedersen, Mikkel W."'

2. Population genomics of the Viking world

Author

Margaryan, Ashot, Lawson, Daniel J, Sikora, Martin, Racimo, Fernando, Rasmussen, Simon, Moltke, Ida, Cassidy, Lara M, Jørsboe, Emil, Ingason, Andrés, Pedersen, Mikkel W, Korneliussen, Thorfinn, Wilhelmson, Helene, Buś, Magdalena M, de Barros Damgaard, Peter, Martiniano, Rui, Renaud, Gabriel, Bhérer, Claude, Moreno-Mayar, J Víctor, Fotakis, Anna K, Allen, Marie, Allmäe, Raili, Molak, Martyna, Cappellini, Enrico, Scorrano, Gabriele, McColl, Hugh, Buzhilova, Alexandra, Fox, Allison, Albrechtsen, Anders, Schütz, Berit, Skar, Birgitte, Arcini, Caroline, Falys, Ceri, Jonson, Charlotte Hedenstierna, Błaszczyk, Dariusz, Pezhemsky, Denis, Turner-Walker, Gordon, Gestsdóttir, Hildur, Lundstrøm, Inge, Gustin, Ingrid, Mainland, Ingrid, Potekhina, Inna, Muntoni, Italo M, Cheng, Jade, Stenderup, Jesper, Ma, Jilong, Gibson, Julie, Peets, Jüri, Gustafsson, Jörgen, Iversen, Katrine H, Simpson, Linzi, Strand, Lisa, Loe, Louise, Sikora, Maeve, Florek, Marek, Vretemark, Maria, Redknap, Mark, Bajka, Monika, Pushkina, Tamara, Søvsø, Morten, Grigoreva, Natalia, Christensen, Tom, Kastholm, Ole, Uldum, Otto, Favia, Pasquale, Holck, Per, Sten, Sabine, Arge, Símun V, Ellingvåg, Sturla, Moiseyev, Vayacheslav, Bogdanowicz, Wiesław, Magnusson, Yvonne, Orlando, Ludovic, Pentz, Peter, Jessen, Mads Dengsø, Pedersen, Anne, Collard, Mark, Bradley, Daniel G, Jørkov, Marie Louise, Arneborg, Jette, Lynnerup, Niels, Price, Neil, Gilbert, M Thomas P, Allentoft, Morten E, Bill, Jan, Sindbæk, Søren M, Hedeager, Lotte, Kristiansen, Kristian, Nielsen, Rasmus, Werge, Thomas, and Willerslev, Eske

Subjects
Biological Sciences, Genetics, History, Heritage and Archaeology, Archaeology, Historical Studies, Human Genome, Underpinning research, 1.1 Normal biological development and functioning, Alleles, Datasets as Topic, England, Evolution, Molecular, Gene Flow, Genetics, Population, Genome, Human, Genomics, Greenland, History, Medieval, Human Migration, Humans, Immunity, Ireland, Lactase, Male, Scandinavian and Nordic Countries, Selection, Genetic, Spatio-Temporal Analysis, Young Adult, General Science & Technology
Abstract

The maritime expansion of Scandinavian populations during the Viking Age (about AD 750-1050) was a far-flung transformation in world history1,2. Here we sequenced the genomes of 442 humans from archaeological sites across Europe and Greenland (to a median depth of about 1×) to understand the global influence of this expansion. We find the Viking period involved gene flow into Scandinavia from the south and east. We observe genetic structure within Scandinavia, with diversity hotspots in the south and restricted gene flow within Scandinavia. We find evidence for a major influx of Danish ancestry into England; a Swedish influx into the Baltic; and Norwegian influx into Ireland, Iceland and Greenland. Additionally, we see substantial ancestry from elsewhere in Europe entering Scandinavia during the Viking Age. Our ancient DNA analysis also revealed that a Viking expedition included close family members. By comparing with modern populations, we find that pigmentation-associated loci have undergone strong population differentiation during the past millennium, and trace positively selected loci-including the lactase-persistence allele of LCT and alleles of ANKA that are associated with the immune response-in detail. We conclude that the Viking diaspora was characterized by substantial transregional engagement: distinct populations influenced the genomic makeup of different regions of Europe, and Scandinavia experienced increased contact with the rest of the continent.

Published
2020

4. Postglacial viability and colonization in North America’s ice-free corridor

Author

Pedersen, Mikkel W, Ruter, Anthony, Schweger, Charles, Friebe, Harvey, Staff, Richard A, Kjeldsen, Kristian K, Mendoza, Marie LZ, Beaudoin, Alwynne B, Zutter, Cynthia, Larsen, Nicolaj K, Potter, Ben A, Nielsen, Rasmus, Rainville, Rebecca A, Orlando, Ludovic, Meltzer, David J, Kjær, Kurt H, and Willerslev, Eske

Subjects
Earth Sciences, Physical Geography and Environmental Geoscience, Geology, Climate Action, Animal Migration, Animals, Bison, DNA, Deer, Forests, Fossils, Genomics, Geologic Sediments, History, Ancient, Human Migration, Humans, Ice Cover, Mammoths, Models, Theoretical, North America, Pollen, Radiometric Dating, Siberia, General Science & Technology
Abstract

During the Last Glacial Maximum, continental ice sheets isolated Beringia (northeast Siberia and northwest North America) from unglaciated North America. By around 15 to 14 thousand calibrated radiocarbon years before present (cal. kyr bp), glacial retreat opened an approximately 1,500-km-long corridor between the ice sheets. It remains unclear when plants and animals colonized this corridor and it became biologically viable for human migration. We obtained radiocarbon dates, pollen, macrofossils and metagenomic DNA from lake sediment cores in a bottleneck portion of the corridor. We find evidence of steppe vegetation, bison and mammoth by approximately 12.6 cal. kyr bp, followed by open forest, with evidence of moose and elk at about 11.5 cal. kyr bp, and boreal forest approximately 10 cal. kyr bp. Our findings reveal that the first Americans, whether Clovis or earlier groups in unglaciated North America before 12.6 cal. kyr bp, are unlikely to have travelled by this route into the Americas. However, later groups may have used this north-south passageway.

Published
2016

8. Abstract CT274: Individualized APC targeting VB10.NEO cancer vaccines induce broad neoepitope-specific CD8 T cell responses in patients with advanced or metastatic solid tumors: interim results from a phase 1/2a trial

Author

Krauss, Jürgen, primary, Krakhardt, Angela, additional, Eisenmann, Stephan, additional, Ochsenreither, Sebastian, additional, Berg, Kaja C.G, additional, Kushekhar, Kushi, additional, Fallang, Lars-Egil, additional, Pedersen, Mikkel W., additional, Torhaug, Siri, additional, Slot, Karsten B., additional, and Schjetne, Karoline, additional

Published
2023
Full Text
View/download PDF

11. Data from Safety and Activity of the First-in-Class Sym004 Anti-EGFR Antibody Mixture in Patients with Refractory Colorectal Cancer

Author

Dienstmann, Rodrigo, primary, Patnaik, Amita, primary, Garcia-Carbonero, Rocio, primary, Cervantes, Andrés, primary, Benavent, Marta, primary, Roselló, Susana, primary, Tops, Bastiaan B.J., primary, van der Post, Rachel S., primary, Argilés, Guillem, primary, Skartved, Niels J.Ø., primary, Hansen, Ulla H., primary, Hald, Rikke, primary, Pedersen, Mikkel W., primary, Kragh, Michael, primary, Horak, Ivan D., primary, Braun, Stephan, primary, Van Cutsem, Eric, primary, Tolcher, Anthony W., primary, and Tabernero, Josep, primary

Published
2023
Full Text
View/download PDF

12. Supplementary methods from Simultaneous Targeting of Two Distinct Epitopes on MET Effectively Inhibits MET- and HGF-Driven Tumor Growth by Multiple Mechanisms

Author

Grandal, Michael M., primary, Havrylov, Serhiy, primary, Poulsen, Thomas T., primary, Koefoed, Klaus, primary, Dahlman, Anna, primary, Galler, Gunther R., primary, Conrotto, Paolo, primary, Collins, Sara, primary, Eriksen, Karsten W., primary, Kaufman, Dafna, primary, Woude, George F.Vande, primary, Jacobsen, Helle J., primary, Horak, Ivan D., primary, Kragh, Michael, primary, Lantto, Johan, primary, Bouquin, Thomas, primary, Park, Morag, primary, and Pedersen, Mikkel W., primary

Published
2023
Full Text
View/download PDF

16. Supplementary Figures 1-7 from Simultaneous Targeting of Two Distinct Epitopes on MET Effectively Inhibits MET- and HGF-Driven Tumor Growth by Multiple Mechanisms

Author

Grandal, Michael M., primary, Havrylov, Serhiy, primary, Poulsen, Thomas T., primary, Koefoed, Klaus, primary, Dahlman, Anna, primary, Galler, Gunther R., primary, Conrotto, Paolo, primary, Collins, Sara, primary, Eriksen, Karsten W., primary, Kaufman, Dafna, primary, Woude, George F.Vande, primary, Jacobsen, Helle J., primary, Horak, Ivan D., primary, Kragh, Michael, primary, Lantto, Johan, primary, Bouquin, Thomas, primary, Park, Morag, primary, and Pedersen, Mikkel W., primary

Published
2023
Full Text
View/download PDF

18. Data from Simultaneous Targeting of Two Distinct Epitopes on MET Effectively Inhibits MET- and HGF-Driven Tumor Growth by Multiple Mechanisms

Author

Grandal, Michael M., primary, Havrylov, Serhiy, primary, Poulsen, Thomas T., primary, Koefoed, Klaus, primary, Dahlman, Anna, primary, Galler, Gunther R., primary, Conrotto, Paolo, primary, Collins, Sara, primary, Eriksen, Karsten W., primary, Kaufman, Dafna, primary, Woude, George F.Vande, primary, Jacobsen, Helle J., primary, Horak, Ivan D., primary, Kragh, Michael, primary, Lantto, Johan, primary, Bouquin, Thomas, primary, Park, Morag, primary, and Pedersen, Mikkel W., primary

Published
2023
Full Text
View/download PDF

20. Supplementary Figure S1 from Safety and Activity of the First-in-Class Sym004 Anti-EGFR Antibody Mixture in Patients with Refractory Colorectal Cancer

Author

Dienstmann, Rodrigo, primary, Patnaik, Amita, primary, Garcia-Carbonero, Rocio, primary, Cervantes, Andrés, primary, Benavent, Marta, primary, Roselló, Susana, primary, Tops, Bastiaan B.J., primary, van der Post, Rachel S., primary, Argilés, Guillem, primary, Skartved, Niels J.Ø., primary, Hansen, Ulla H., primary, Hald, Rikke, primary, Pedersen, Mikkel W., primary, Kragh, Michael, primary, Horak, Ivan D., primary, Braun, Stephan, primary, Van Cutsem, Eric, primary, Tolcher, Anthony W., primary, and Tabernero, Josep, primary

Published
2023
Full Text
View/download PDF

22. Supplementary Table S2 from Safety and Activity of the First-in-Class Sym004 Anti-EGFR Antibody Mixture in Patients with Refractory Colorectal Cancer

Author

Dienstmann, Rodrigo, primary, Patnaik, Amita, primary, Garcia-Carbonero, Rocio, primary, Cervantes, Andrés, primary, Benavent, Marta, primary, Roselló, Susana, primary, Tops, Bastiaan B.J., primary, van der Post, Rachel S., primary, Argilés, Guillem, primary, Skartved, Niels J.Ø., primary, Hansen, Ulla H., primary, Hald, Rikke, primary, Pedersen, Mikkel W., primary, Kragh, Michael, primary, Horak, Ivan D., primary, Braun, Stephan, primary, Van Cutsem, Eric, primary, Tolcher, Anthony W., primary, and Tabernero, Josep, primary

Published
2023
Full Text
View/download PDF

23. Supplementary Figure Legend from Safety and Activity of the First-in-Class Sym004 Anti-EGFR Antibody Mixture in Patients with Refractory Colorectal Cancer

Author

Dienstmann, Rodrigo, primary, Patnaik, Amita, primary, Garcia-Carbonero, Rocio, primary, Cervantes, Andrés, primary, Benavent, Marta, primary, Roselló, Susana, primary, Tops, Bastiaan B.J., primary, van der Post, Rachel S., primary, Argilés, Guillem, primary, Skartved, Niels J.Ø., primary, Hansen, Ulla H., primary, Hald, Rikke, primary, Pedersen, Mikkel W., primary, Kragh, Michael, primary, Horak, Ivan D., primary, Braun, Stephan, primary, Van Cutsem, Eric, primary, Tolcher, Anthony W., primary, and Tabernero, Josep, primary

Published
2023
Full Text
View/download PDF

24. Supplementary Figures S1-8 from Pan-HER, an Antibody Mixture Simultaneously Targeting EGFR, HER2, and HER3, Effectively Overcomes Tumor Heterogeneity and Plasticity

Author

Jacobsen, Helle J., primary, Poulsen, Thomas T., primary, Dahlman, Anna, primary, Kjær, Ida, primary, Koefoed, Klaus, primary, Sen, Jette W., primary, Weilguny, Dietmar, primary, Bjerregaard, Bolette, primary, Andersen, Christina R., primary, Horak, Ivan D., primary, Pedersen, Mikkel W., primary, Kragh, Michael, primary, and Lantto, Johan, primary

Published
2023
Full Text
View/download PDF

25. Supplementary Tables S1-2 from Pan-HER, an Antibody Mixture Simultaneously Targeting EGFR, HER2, and HER3, Effectively Overcomes Tumor Heterogeneity and Plasticity

Author

Jacobsen, Helle J., primary, Poulsen, Thomas T., primary, Dahlman, Anna, primary, Kjær, Ida, primary, Koefoed, Klaus, primary, Sen, Jette W., primary, Weilguny, Dietmar, primary, Bjerregaard, Bolette, primary, Andersen, Christina R., primary, Horak, Ivan D., primary, Pedersen, Mikkel W., primary, Kragh, Michael, primary, and Lantto, Johan, primary

Published
2023
Full Text
View/download PDF

26. Author Correction: Population genomics of the Viking world

Author

Margaryan, Ashot, Lawson, Daniel J., Sikora, Martin, Racimo, Fernando, Rasmussen, Simon, Moltke, Ida, Cassidy, Lara M., Jørsboe, Emil, Ingason, Andrés, Pedersen, Mikkel W., Korneliussen, Thorfinn, Wilhelmson, Helene, Buś, Magdalena M., de Barros Damgaard, Peter, Martiniano, Rui, Renaud, Gabriel, Bhérer, Claude, Moreno-Mayar, J. Víctor, Fotakis, Anna K., Allen, Marie, Allmäe, Raili, Molak, Martyna, Cappellini, Enrico, Scorrano, Gabriele, McColl, Hugh, Buzhilova, Alexandra, Fox, Allison, Albrechtsen, Anders, Schütz, Berit, Skar, Birgitte, Arcini, Caroline, Falys, Ceri, Jonson, Charlotte Hedenstierna, Błaszczyk, Dariusz, Pezhemsky, Denis, Turner-Walker, Gordon, Gestsdóttir, Hildur, Lundstrøm, Inge, Gustin, Ingrid, Mainland, Ingrid, Potekhina, Inna, Muntoni, Italo M., Cheng, Jade, Stenderup, Jesper, Ma, Jilong, Gibson, Julie, Peets, Jüri, Gustafsson, Jörgen, Iversen, Katrine H., Simpson, Linzi, Strand, Lisa, Loe, Louise, Sikora, Maeve, Florek, Marek, Vretemark, Maria, Redknap, Mark, Bajka, Monika, Pushkina, Tamara, Søvsø, Morten, Grigoreva, Natalia, Christensen, Tom, Kastholm, Ole, Uldum, Otto, Favia, Pasquale, Holck, Per, Sten, Sabine, Arge, Símun V., Ellingvåg, Sturla, Moiseyev, Vayacheslav, Bogdanowicz, Wiesław, Magnusson, Yvonne, Orlando, Ludovic, Pentz, Peter, Jessen, Mads Dengsø, Pedersen, Anne, Collard, Mark, Bradley, Daniel G., Jørkov, Marie Louise, Arneborg, Jette, Lynnerup, Niels, Price, Neil, Gilbert, M. Thomas P., Allentoft, Morten E., Bill, Jan, Sindbæk, Søren M., Hedeager, Lotte, Kristiansen, Kristian, Nielsen, Rasmus, Werge, Thomas, and Willerslev, Eske

Published
2021
Full Text
View/download PDF

27. An ERBB1-3 Neutralizing Antibody Mixture With High Activity Against Drug-Resistant HER2+ Breast Cancers With ERBB Ligand Overexpression

Author

Schwarz, Luis J., Hutchinson, Katherine E., Rexer, Brent N., Estrada, Mónica Valeria, Gonzalez Ericsson, Paula I., Sanders, Melinda E., Dugger, Teresa C., Formisano, Luigi, Guerrero-Zotano, Angel, Red-Brewer, Monica, Young, Christian D., Lantto, Johan, Pedersen, Mikkel W., Kragh, Michael, Horak, Ivan D., and Arteaga, Carlos L.

Published
2017
Full Text
View/download PDF

29. Ancient Human Genomes and Environmental DNA from the Cement Attaching 2,000-Year-Old Head Lice Nits

Author

Pedersen, Mikkel W., Antunes, Catia, De Cahsan, Binia, Moreno-Mayar, J. Víctor, Sikora, Martin, Vinner, Lasse, Mann, Darren, Klimov, Pavel B, Black, Stuart, Michieli, Catalina Teresa, Braig, Henk R., Perotti, M. Alejandra, Pedersen, Mikkel W., Antunes, Catia, De Cahsan, Binia, Moreno-Mayar, J. Víctor, Sikora, Martin, Vinner, Lasse, Mann, Darren, Klimov, Pavel B, Black, Stuart, Michieli, Catalina Teresa, Braig, Henk R., and Perotti, M. Alejandra

Abstract

Over the past few decades, there has been a growing demand for genome analysis of ancient human remains. Destructive sampling is increasingly difficult to obtain for ethical reasons, and standard methods of breaking the skull to access the petrous bone or sampling remaining teeth are often forbidden for curatorial reasons. However, most ancient humans carried head lice and their eggs abound in historical hair specimens. Here we show that host DNA is protected by the cement that glues head lice nits to the hair of ancient Argentinian mummies, 1,500-2,000 years old. The genetic affinities deciphered from genome-wide analyses of this DNA inform that this population migrated from north-west Amazonia to the Andes of central-west Argentina; a result confirmed using the mitochondria of the host lice. The cement preserves ancient environmental DNA of the skin, including the earliest recorded case of Merkel cell polyomavirus. We found that the percentage of human DNA obtained from nit cement equals human DNA obtained from the tooth, yield 2-fold compared with a petrous bone, and 4-fold to a bloodmeal of adult lice a millennium younger. In metric studies of sheaths, the length of the cement negatively correlates with the age of the specimens, whereas hair linear distance between nit and scalp informs about the environmental conditions at the time before death. Ectoparasitic lice sheaths can offer an alternative, nondestructive source of high-quality ancient DNA from a variety of host taxa where bones and teeth are not available and reveal complementary details of their history.

Published
2022

30. Chiquihuite Cave and America's Hidden Limestone Industries:A Reply to Chatters et al.

Author

Ardelean, Ciprian F., Pedersen, Mikkel W., Schwenninger, Jean-Luc, Arroyo-Cabrales, Joaquin, Gandy, Devlin A., Sikora, Martin, Macías-Quintero, Juan I., Huerta-Arellano, Vladimir, De La Rosa-Díaz, Jesús J., Ocampo-Díaz, Yam Zul E., Rubio-Cisneros, Igor I., Barba-Pingarón, Luis, Ortíz-Butrón, Agustín, Blancas-Vázquez, Jorge, Solís-Rosales, Corina, Rodríguez-Ceja, María, Rivera-González, Irán, Navarro-Gutiérrez, Zamara, López-Jiménez, Alejandro, Marroquín-Fernández, Marco B., Martínez-Riojas, Luis M., Willerslev, Eske, Ardelean, Ciprian F., Pedersen, Mikkel W., Schwenninger, Jean-Luc, Arroyo-Cabrales, Joaquin, Gandy, Devlin A., Sikora, Martin, Macías-Quintero, Juan I., Huerta-Arellano, Vladimir, De La Rosa-Díaz, Jesús J., Ocampo-Díaz, Yam Zul E., Rubio-Cisneros, Igor I., Barba-Pingarón, Luis, Ortíz-Butrón, Agustín, Blancas-Vázquez, Jorge, Solís-Rosales, Corina, Rodríguez-Ceja, María, Rivera-González, Irán, Navarro-Gutiérrez, Zamara, López-Jiménez, Alejandro, Marroquín-Fernández, Marco B., Martínez-Riojas, Luis M., and Willerslev, Eske

Published
2022

31. Ancient Human Genomes and Environmental DNA from the Cement Attaching 2,000-Year-Old Head Lice Nits

Author

Pedersen, Mikkel W, primary, Antunes, Catia, additional, De Cahsan, Binia, additional, Moreno-Mayar, J Víctor, additional, Sikora, Martin, additional, Vinner, Lasse, additional, Mann, Darren, additional, Klimov, Pavel B, additional, Black, Stuart, additional, Michieli, Catalina Teresa, additional, Braig, Henk R, additional, and Perotti, M Alejandra, additional

Published
2021
Full Text
View/download PDF

34. Chiquihuite Cave and America’s Hidden Limestone Industries: A Reply to Chatters et al.

Author

Ardelean, Ciprian F., primary, Pedersen, Mikkel W., additional, Schwenninger, Jean-Luc, additional, Arroyo-Cabrales, Joaquín, additional, Gandy, Devlin A., additional, Sikora, Martin, additional, Macías-Quintero, Juan I., additional, Huerta-Arellano, Vladimir, additional, De La Rosa-Díaz, Jesús J., additional, Ocampo-Díaz, Yam Zul E., additional, Rubio-Cisneros, Igor I., additional, Barba-Pingarón, Luis, additional, Ortíz-Butrón, Agustín, additional, Blancas-Vázquez, Jorge, additional, Solís-Rosales, Corina, additional, Rodríguez-Ceja, María, additional, Rivera-González, Irán, additional, Navarro-Gutiérrez, Zamara, additional, López-Jiménez, Alejandro, additional, Marroquín-Fernández, Marco B., additional, Martínez-Riojas, Luis M., additional, and Willerslev, Eske, additional

Published
2021
Full Text
View/download PDF

35. Abstract 1797: Preclinical characterization of Sym024, a novel anti-CD73 antibody

Author

Jakobsen, Janus S., primary, Riva, Matteo, additional, Melander, Maria C., additional, Hansen, Randi W., additional, Kofoed, Klaus, additional, Pedersen, Mikkel W., additional, Deckert, Jutta, additional, Hansen, Lene, additional, Skartved, Niels Jorgen, additional, Lantto, Johan, additional, Frohlich, Camilla, additional, and Grandal, Michael Monrad, additional

Published
2021
Full Text
View/download PDF

36. Lake Sedimentary DNA Research on Past Terrestrial and Aquatic Biodiversity: Overview and Recommendations

Author

Capo, Eric, Giguet-Covex, Charline, Rouillard, Alexandra, Nota, Kevin, Heintzman, Peter D., Vuillemin, Aurèle, Ariztegui, Daniel, Arnaud, Fabien, Belle, Simon, Bertilsson, Stefan, Bigler, Christian, Bindler, Richard, Brown, Antony G., Clarke, Charlotte L., Crump, Sarah E., Debroas, Didier, Englund, Göran, Ficetola, Gentile Francesco, Garner, Rebecca E., Gauthier, Joanna, Gregory-Eaves, Irene, Heinecke, Liv, Herzschuh, Ulrike, Ibrahim, Anan, Kisand, Veljo, Kjær, Kurt H., Lammers, Youri, Littlefair, Joanne, Messager, Erwan, Monchamp, Marie-Eve, Olajos, Fredrik, Orsi, William, Pedersen, Mikkel W., Rijal, Dilli P., Rydberg, Johan, Spanbauer, Trisha, Stoof-Leichsenring, Kathleen R., Taberlet, Pierre, Talas, Liisi, Thomas, Camille, Walsh, David A., Wang, Yucheng, Willerslev, Eske, van Woerkom, Anne, Zimmermann, Heike H., Coolen, Marco J. L., Epp, Laura S., Domaizon, Isabelle, G. Alsos, Inger, Parducci, Laura, Capo, Eric, Giguet-Covex, Charline, Rouillard, Alexandra, Nota, Kevin, Heintzman, Peter D., Vuillemin, Aurèle, Ariztegui, Daniel, Arnaud, Fabien, Belle, Simon, Bertilsson, Stefan, Bigler, Christian, Bindler, Richard, Brown, Antony G., Clarke, Charlotte L., Crump, Sarah E., Debroas, Didier, Englund, Göran, Ficetola, Gentile Francesco, Garner, Rebecca E., Gauthier, Joanna, Gregory-Eaves, Irene, Heinecke, Liv, Herzschuh, Ulrike, Ibrahim, Anan, Kisand, Veljo, Kjær, Kurt H., Lammers, Youri, Littlefair, Joanne, Messager, Erwan, Monchamp, Marie-Eve, Olajos, Fredrik, Orsi, William, Pedersen, Mikkel W., Rijal, Dilli P., Rydberg, Johan, Spanbauer, Trisha, Stoof-Leichsenring, Kathleen R., Taberlet, Pierre, Talas, Liisi, Thomas, Camille, Walsh, David A., Wang, Yucheng, Willerslev, Eske, van Woerkom, Anne, Zimmermann, Heike H., Coolen, Marco J. L., Epp, Laura S., Domaizon, Isabelle, G. Alsos, Inger, and Parducci, Laura

Abstract

The use of lake sedimentary DNA to track the long-term changes in both terrestrial and aquatic biota is a rapidly advancing field in paleoecological research. Although largely applied nowadays, knowledge gaps remain in this field and there is therefore still research to be conducted to ensure the reliability of the sedimentary DNA signal. Building on the most recent literature and seven original case studies, we synthesize the state-of-the-art analytical procedures for effective sampling, extraction, amplification, quantification and/or generation of DNA inventories from sedimentary ancient DNA (sedaDNA) via high-throughput sequencing technologies. We provide recommendations based on current knowledge and best practises

Published
2021

37. Lake Sedimentary DNA Research on Past Terrestrial and Aquatic Biodiversity:Overview and Recommendations

Author

Capo, Eric, Giguet-Covex, Charline, Rouillard, Alexandra, Nota, Kevin, Heintzman, Peter D., Vuillemin, Aurele, Ariztegui, Daniel, Arnaud, Fabien, Belle, Simon, Bertilsson, Stefan, Bigler, Christian, Bindler, Richard, Brown, Antony G., Clarke, Charlotte L., Crump, Sarah E., Debroas, Didier, Englund, Göran, Ficetola, Gentile Francesco, Garner, Rebecca E., Gauthier, Joanna, Gregory-Eaves, Irene, Heinecke, Liv, Herzschuh, Ulrike, Ibrahim, Anan, Kisand, Veljo, Kjær, Kurt H., Lammers, Youri, Littlefair, Joanne, Messager, Erwan, Monchamp, Marie-Eve, Olajos, Fredrik, Orsi, William, Pedersen, Mikkel W., Rijal, Dilli P., Rydberg, Johan, Spanbauer, Trisha, Stoof-Leichsenring, Kathleen R., Taberlet, Pierre, Talas, Liisi, Thomas, Camille, Walsh, David A., Wang, Yucheng, Willerslev, Eske, van Woerkom, Anne, Zimmermann, Heike H., Coolen, Marco J. L., Epp, Laura S., Domaizon, Isabelle, Alsos, Inger G., Parducci, Laura, Capo, Eric, Giguet-Covex, Charline, Rouillard, Alexandra, Nota, Kevin, Heintzman, Peter D., Vuillemin, Aurele, Ariztegui, Daniel, Arnaud, Fabien, Belle, Simon, Bertilsson, Stefan, Bigler, Christian, Bindler, Richard, Brown, Antony G., Clarke, Charlotte L., Crump, Sarah E., Debroas, Didier, Englund, Göran, Ficetola, Gentile Francesco, Garner, Rebecca E., Gauthier, Joanna, Gregory-Eaves, Irene, Heinecke, Liv, Herzschuh, Ulrike, Ibrahim, Anan, Kisand, Veljo, Kjær, Kurt H., Lammers, Youri, Littlefair, Joanne, Messager, Erwan, Monchamp, Marie-Eve, Olajos, Fredrik, Orsi, William, Pedersen, Mikkel W., Rijal, Dilli P., Rydberg, Johan, Spanbauer, Trisha, Stoof-Leichsenring, Kathleen R., Taberlet, Pierre, Talas, Liisi, Thomas, Camille, Walsh, David A., Wang, Yucheng, Willerslev, Eske, van Woerkom, Anne, Zimmermann, Heike H., Coolen, Marco J. L., Epp, Laura S., Domaizon, Isabelle, Alsos, Inger G., and Parducci, Laura

Abstract

The use of lake sedimentary DNA to track the long-term changes in both terrestrial and aquatic biota is a rapidly advancing field in paleoecological research. Although largely applied nowadays, knowledge gaps remain in this field and there is therefore still research to be conducted to ensure the reliability of the sedimentary DNA signal. Building on the most recent literature and seven original case studies, we synthesize the state-of-the-art analytical procedures for effective sampling, extraction, amplification, quantification and/or generation of DNA inventories from sedimentary ancient DNA (sedaDNA) via high-throughput sequencing technologies. We provide recommendations based on current knowledge and best practises.

Published
2021

38. Lake Sedimentary DNA Research on Past Terrestrial and Aquatic Biodiversity: Overview and Recommendations

Author

Capo, Eric, primary, Giguet-Covex, Charline, additional, Rouillard, Alexandra, additional, Nota, Kevin, additional, Heintzman, Peter D., additional, Vuillemin, Aurèle, additional, Ariztegui, Daniel, additional, Arnaud, Fabien, additional, Belle, Simon, additional, Bertilsson, Stefan, additional, Bigler, Christian, additional, Bindler, Richard, additional, Brown, Antony G., additional, Clarke, Charlotte L., additional, Crump, Sarah E., additional, Debroas, Didier, additional, Englund, Göran, additional, Ficetola, Gentile Francesco, additional, Garner, Rebecca E., additional, Gauthier, Joanna, additional, Gregory-Eaves, Irene, additional, Heinecke, Liv, additional, Herzschuh, Ulrike, additional, Ibrahim, Anan, additional, Kisand, Veljo, additional, Kjær, Kurt H., additional, Lammers, Youri, additional, Littlefair, Joanne, additional, Messager, Erwan, additional, Monchamp, Marie-Eve, additional, Olajos, Fredrik, additional, Orsi, William, additional, Pedersen, Mikkel W., additional, Rijal, Dilli P., additional, Rydberg, Johan, additional, Spanbauer, Trisha, additional, Stoof-Leichsenring, Kathleen R., additional, Taberlet, Pierre, additional, Talas, Liisi, additional, Thomas, Camille, additional, Walsh, David A., additional, Wang, Yucheng, additional, Willerslev, Eske, additional, van Woerkom, Anne, additional, Zimmermann, Heike H., additional, Coolen, Marco J. L., additional, Epp, Laura S., additional, Domaizon, Isabelle, additional, G. Alsos, Inger, additional, and Parducci, Laura, additional

Published
2021
Full Text
View/download PDF

41. Colorectal cancer residual disease at maximal response to EGFR blockade displays a druggable Paneth cell–like phenotype

Author

Lupo, Barbara, primary, Sassi, Francesco, additional, Pinnelli, Marika, additional, Galimi, Francesco, additional, Zanella, Eugenia R., additional, Vurchio, Valentina, additional, Migliardi, Giorgia, additional, Gagliardi, Paolo Armando, additional, Puliafito, Alberto, additional, Manganaro, Daria, additional, Luraghi, Paolo, additional, Kragh, Michael, additional, Pedersen, Mikkel W., additional, Horak, Ivan D., additional, Boccaccio, Carla, additional, Medico, Enzo, additional, Primo, Luca, additional, Nichol, Daniel, additional, Spiteri, Inmaculada, additional, Heide, Timon, additional, Vatsiou, Alexandra, additional, Graham, Trevor A., additional, Élez, Elena, additional, Argiles, Guillem, additional, Nuciforo, Paolo, additional, Sottoriva, Andrea, additional, Dienstmann, Rodrigo, additional, Pasini, Diego, additional, Grassi, Elena, additional, Isella, Claudio, additional, Bertotti, Andrea, additional, and Trusolino, Livio, additional

Published
2020
Full Text
View/download PDF

42. Ancient Human Genomes and Environmental DNA from the Cement Attaching 2,000-Year-Old Head Lice Nits.

Author

Pedersen, Mikkel W, Antunes, Catia, Cahsan, Binia De, Moreno-Mayar, J Víctor, Sikora, Martin, Vinner, Lasse, Mann, Darren, Klimov, Pavel B, Black, Stuart, Michieli, Catalina Teresa, Braig, Henk R, and Perotti, M Alejandra

Subjects
MERKEL cells, GENOMES, POLYOMAVIRUSES, FOSSIL DNA, HUMAN DNA
Abstract

Over the past few decades, there has been a growing demand for genome analysis of ancient human remains. Destructive sampling is increasingly difficult to obtain for ethical reasons, and standard methods of breaking the skull to access the petrous bone or sampling remaining teeth are often forbidden for curatorial reasons. However, most ancient humans carried head lice and their eggs abound in historical hair specimens. Here we show that host DNA is protected by the cement that glues head lice nits to the hair of ancient Argentinian mummies, 1,500–2,000 years old. The genetic affinities deciphered from genome-wide analyses of this DNA inform that this population migrated from north-west Amazonia to the Andes of central-west Argentina; a result confirmed using the mitochondria of the host lice. The cement preserves ancient environmental DNA of the skin, including the earliest recorded case of Merkel cell polyomavirus. We found that the percentage of human DNA obtained from nit cement equals human DNA obtained from the tooth, yield 2-fold compared with a petrous bone, and 4-fold to a bloodmeal of adult lice a millennium younger. In metric studies of sheaths, the length of the cement negatively correlates with the age of the specimens, whereas hair linear distance between nit and scalp informs about the environmental conditions at the time before death. Ectoparasitic lice sheaths can offer an alternative, nondestructive source of high-quality ancient DNA from a variety of host taxa where bones and teeth are not available and reveal complementary details of their history. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

44. Population genomics of the Viking world:[incl. correction]

Author

Margaryan, Ashot, Lawson, Daniel J, Sikora, Martin, Racimo, Fernando, Rasmussen, Simon, Moltke, Ida, Cassidy, Lara M, Jørsboe, Emil, Ingason, Andrés, Pedersen, Mikkel W, Korneliussen, Thorfinn, Wilhelmson, Helene, Buś, Magdalena M, de Barros Damgaard, Peter, Martiniano, Rui, Renaud, Gabriel, Bhérer, Claude, Moreno-Mayar, J Víctor, Fotakis, Anna K, Allen, Marie, Allmäe, Raili, Molak, Martyna, Cappellini, Enrico, Scorrano, Gabriele, McColl, Hugh, Buzhilova, Alexandra, Fox, Allison, Albrechtsen, Anders, Schütz, Berit, Skar, Birgitte, Arcini, Caroline, Lundstrøm, Inge, Cheng, Jade, Stenderup, Jesper, Iversen, Katrine H, Arge, Símun V, Ellingvåg, Sturla, Orlando, Ludovic, Pentz, Peter, Jessen, Mads Dengsø, Pedersen, Anne, Jørkov, Marie Louise, Lynnerup, Niels, Gilbert, M Thomas P, Allentoft, Morten E, Sindbæk, Søren M, Kristiansen, Kristian, Nielsen, Rasmus, Werge, Thomas, Willerslev, Eske, Margaryan, Ashot, Lawson, Daniel J, Sikora, Martin, Racimo, Fernando, Rasmussen, Simon, Moltke, Ida, Cassidy, Lara M, Jørsboe, Emil, Ingason, Andrés, Pedersen, Mikkel W, Korneliussen, Thorfinn, Wilhelmson, Helene, Buś, Magdalena M, de Barros Damgaard, Peter, Martiniano, Rui, Renaud, Gabriel, Bhérer, Claude, Moreno-Mayar, J Víctor, Fotakis, Anna K, Allen, Marie, Allmäe, Raili, Molak, Martyna, Cappellini, Enrico, Scorrano, Gabriele, McColl, Hugh, Buzhilova, Alexandra, Fox, Allison, Albrechtsen, Anders, Schütz, Berit, Skar, Birgitte, Arcini, Caroline, Lundstrøm, Inge, Cheng, Jade, Stenderup, Jesper, Iversen, Katrine H, Arge, Símun V, Ellingvåg, Sturla, Orlando, Ludovic, Pentz, Peter, Jessen, Mads Dengsø, Pedersen, Anne, Jørkov, Marie Louise, Lynnerup, Niels, Gilbert, M Thomas P, Allentoft, Morten E, Sindbæk, Søren M, Kristiansen, Kristian, Nielsen, Rasmus, Werge, Thomas, and Willerslev, Eske

Abstract

The maritime expansion of Scandinavian populations during the Viking Age (about AD 750-1050) was a far-flung transformation in world history1,2. Here we sequenced the genomes of 442 humans from archaeological sites across Europe and Greenland (to a median depth of about 1×) to understand the global influence of this expansion. We find the Viking period involved gene flow into Scandinavia from the south and east. We observe genetic structure within Scandinavia, with diversity hotspots in the south and restricted gene flow within Scandinavia. We find evidence for a major influx of Danish ancestry into England; a Swedish influx into the Baltic; and Norwegian influx into Ireland, Iceland and Greenland. Additionally, we see substantial ancestry from elsewhere in Europe entering Scandinavia during the Viking Age. Our ancient DNA analysis also revealed that a Viking expedition included close family members. By comparing with modern populations, we find that pigmentation-associated loci have undergone strong population differentiation during the past millennium, and trace positively selected loci-including the lactase-persistence allele of LCT and alleles of ANKA that are associated with the immune response-in detail. We conclude that the Viking diaspora was characterized by substantial transregional engagement: distinct populations influenced the genomic makeup of different regions of Europe, and Scandinavia experienced increased contact with the rest of the continent.

Published
2020

47. Sym021, a promising anti-PD1 clinical candidate antibody derived from a new chicken antibody discovery platform

Author

Gjetting, Torben, primary, Gad, Monika, additional, Fröhlich, Camilla, additional, Lindsted, Trine, additional, Melander, Maria C, additional, Bhatia, Vikram K, additional, Grandal, Michael M, additional, Dietrich, Nikolaj, additional, Uhlenbrock, Franziska, additional, Galler, Gunther R, additional, Strandh, Magnus, additional, Lantto, Johan, additional, Bouquin, Thomas, additional, Horak, Ivan D, additional, Kragh, Michael, additional, Pedersen, Mikkel W, additional, and Koefoed, Klaus, additional

Published
2019
Full Text
View/download PDF

48. Shotgun Environmental DNA, Pollen, and Macrofossil Analysis of Lateglacial Lake Sediments From Southern Sweden

Author

Parducci, Laura, Alsos, Inger Greve, Unneberg, Per, Pedersen, Mikkel W., Han, Lu, Lammers, Youri, Salonen, J. Sakari, Valiranta, Minna M., Slotte, Tanja, Wohlfarth, Barbara, Parducci, Laura, Alsos, Inger Greve, Unneberg, Per, Pedersen, Mikkel W., Han, Lu, Lammers, Youri, Salonen, J. Sakari, Valiranta, Minna M., Slotte, Tanja, and Wohlfarth, Barbara

Abstract

The lake sediments of Hasseldala Port in south-east Sweden provide an archive of local and regional environmental conditions similar to 14.5-9.5 ka BP (thousand years before present) and allow testing DNA sequencing techniques to reconstruct past vegetation changes. We combined shotgun sequencing with plant micro- and macrofossil analyses to investigate sediments dating to the Allerod (14.1-12.7 ka BP), Younger Dryas (12.7-11.7 ka BP), and Preboreal (<11.7 ka BP). Number of reads and taxa were not associated with sample age or organic content. This suggests that, beyond the initial rapid degradation, DNA is still present. The proportion of recovered plant DNA was low, but allowed identifying an important number of plant taxa, thus adding valid information on the composition of the local vegetation. Importantly, DNA provides a stronger signal of plant community changes than plant micro- and plant macrofossil analyses alone, since a larger number of new taxa were recorded in Younger Dryas samples. A comparison between the three proxies highlights differences and similarities and supports earlier findings that plants growing close to or within a lake are recorded by DNA. Plant macrofossil remains moreover show that tree birch was present close to the ancient lake since the Allerod; together with the DNA results, this indicates that boreal to subarctic climatic conditions also prevailed during the cold Younger Dryas interval. Increasing DNA reference libraries and enrichment strategies prior to sequencing are necessary to improve the potential and accuracy of plant identification using the shotgun metagenomic approach.

Published
2019
Full Text
View/download PDF

49. Chiquihuite Cave and America’s Hidden Limestone Industries: A Reply to Chatters et al.

Author

Ardelean, Ciprian F., Pedersen, Mikkel W., Schwenninger, Jean-Luc, Arroyo-Cabrales, Joaquín, Gandy, Devlin A., Sikora, Martin, Macías-Quintero, Juan I., Huerta-Arellano, Vladimir, De La Rosa-Díaz, Jesús J., Ocampo-Díaz, Yam Zul E., Rubio-Cisneros, Igor I., Barba-Pingarón, Luis, Ortíz-Butrón, Agustín, Blancas-Vázquez, Jorge, Solís-Rosales, Corina, Rodríguez-Ceja, María, Rivera-González, Irán, Navarro-Gutiérrez, Zamara, López-Jiménez, Alejandro, Marroquín-Fernández, Marco B., Martínez-Riojas, Luis M., and Willerslev, Eske

Abstract

ABSTRACTThis paper is a reply to Chatters et al. (2021. “Evaluating Claims of Early Human Occupation at Chiquihuite Cave, Mexico.” PaleoAmerica8, doi:10.1080/20555563.2021.1940441), in which they raise a large number of doubts about the legitimacy of our claims of earlier-than-expected human presence at Chiquihuite Cave, in northern Zacatecas, Mexico, mainly questioning the artificial nature of the lithic assemblage and the integrity of our geological contexts. We respond to their main topics of concern, contributing arguments in defense of the human origin of the artifacts. We also include 10 examples of stone tools, with full descriptions and photographs, focusing on modified flakes that bear indicators of use-wear and intentional modification.

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results