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842 results on '"Pecorelli S"'

1. Scaling up health knowledge at European level requires sharing integrated data: an approach for collection of database specification

Author: Menditto E, Bolufer de Gea A, Cahir C, Marengoni A, Riegler S, Fico G, Costa E, Monaco A, Pecorelli S, Pani L, and Prados-Torres A
Subjects: healthcare-databases, adherence, electronic health records, outcome research, Medicine (General), R5-920, Therapeutics. Pharmacology, RM1-950
Abstract: Enrica Menditto,1 Angela Bolufer De Gea,2 Caitriona Cahir,3,4 Alessandra Marengoni,5 Salvatore Riegler,1 Giuseppe Fico,6 Elisio Costa,7 Alessandro Monaco,8 Sergio Pecorelli,5 Luca Pani,8 Alexandra Prados-Torres9 1School of Pharmacy, CIRFF/Center of Pharmacoeconomics, University of Naples Federico II, Naples, Italy; 2Directorate-General for Health and Food Safety, European Commission, Brussels, Belgium; 3Division of Population Health Sciences, Royal College of Surgeons in Ireland, 4Department of Pharmacology and Therapeutics, St James’s Hospital, Dublin, Ireland; 5Department of Clinical and Experimental Science, University of Brescia, Brescia; 6Life Supporting Technologies, Photonics Technology and Bioengineering Department, School of Telecomunications Engineering, Polytechnic University of Madrid, Madrid, Spain; 7Faculty of Pharmacy, University of Porto, Porto, Portugal; 8Italian Medicines Agency – AIFA, Rome, Italy; 9EpiChron Research Group on Chronic Diseases, Aragón Health Sciences Institute (IACS), IIS Aragón REDISSEC ISCIII, Miguel Servet University Hospital, University of Zaragoza, Zaragoza, Spain Abstract: Computerized health care databases have been widely described as an excellent opportunity for research. The availability of “big data” has brought about a wave of innovation in projects when conducting health services research. Most of the available secondary data sources are restricted to the geographical scope of a given country and present heterogeneous structure and content. Under the umbrella of the European Innovation Partnership on Active and Healthy Ageing, collaborative work conducted by the partners of the group on “adherence to prescription and medical plans” identified the use of observational and large-population databases to monitor medication-taking behavior in the elderly. This article describes the methodology used to gather the information from available databases among the Adherence Action Group partners with the aim of improving data sharing on a European level. A total of six databases belonging to three different European countries (Spain, Republic of Ireland, and Italy) were included in the analysis. Preliminary results suggest that there are some similarities. However, these results should be applied in different contexts and European countries, supporting the idea that large European studies should be designed in order to get the most of already available databases. Keywords: health care databases, adherence, electronic health records, outcome research
Published: 2016

2. Interventional tools to improve medication adherence: review of literature

Author: Costa E, Giardini A, Savin M, Menditto E, Lehane EA, Laosa O, Pecorelli S, Monaco A, and Marengoni A
Subjects: Medicine (General), R5-920
Abstract: Elísio Costa,1 Anna Giardini,2 Magda Savin,3 Enrica Menditto,4 Elaine Lehane,5 Olga Laosa,6 Sergio Pecorelli,7,8 Alessandro Monaco,7 Alessandra Marengoni9On behalf of the A1 Action group “Prescription and Adherence to Medical Plans”, European Innovation Partnership on Active and Healthy Ageing1UCIBIO, REQUIMTE, Faculty of Pharmacy, University of Porto, Porto, Portugal; 2Psychology Unit, Salvatore Maugeri Foundation, IRCCS, Scientific Institute of Montescano (PV), Pavia, Italy; 3European Association of Pharmaceutical Full-line Wholesalers, Brussels, Belgium; 4CIRFF/Center of Pharmacoeconomics, School of Pharmacy, University of Naples FedericoII, Nápoles, Italy; 5Catherine McAuley School of Nursing and Midwifery, Brookfield Health Sciences Complex, University College Cork, Cork, Ireland; 6Centro de Investigación Clínica del Anciano Fundación para la Investigación Biomédica, Hospital Universitario de Getafe, Madrid, Spain; 7Italian Medicines Agency – AIFA, Rome, Italy; 8University of Brescia, Brescia, Italy; 9Department of Clinical and Experimental Science, University of Brescia, Brescia, Italy Abstract: Medication adherence and persistence is recognized as a worldwide public health problem, particularly important in the management of chronic diseases. Nonadherence to medical plans affects every level of the population, but particularly older adults due to the high number of coexisting diseases they are affected by and the consequent polypharmacy. Chronic disease management requires a continuous psychological adaptation and behavioral reorganization. In literature, many interventions to improve medication adherence have been described for different clinical conditions, however, most interventions seem to fail in their aims. Moreover, most interventions associated with adherence improvements are not associated with improvements in other outcomes. Indeed, in the last decades, the degree of nonadherence remained unchanged. In this work, we review the most frequent interventions employed to increase the degree of medication adherence, the measured outcomes, and the improvements achieved, as well as the main limitations of the available studies on adherence, with a particular focus on older persons.Keywords: cognitive impairment, nonadherence, tools, compliance, chronic diseases, elderly
Published: 2015

3. Erratum to: Building bridges for innovation in ageing: Synergies between action groups of the EIP on AHA

Author: Bousquet, Jean, Bewick, M., Cano, A., Eklund, P., Fico, G., Goswami, N., Guldemond, N. A., Henderson, D., Hinkema, M. J., Liotta, G., Mair, A., Molloy, W., Monaco, A., Monsonis-Paya, I., Nizinska, A., Papadopoulos, H., Pavlickova, A., Pecorelli, S., Prados-Torres, A., Roller-Wirnsberger, R. E., Somekh, D., Vera-Muñoz, C., Visser, F., Farrell, J., Malva, J., Andersen Ranberg, K., Camuzat, T., Carriazo, A. M., Crooks, G., Gutter, Z., Iaccarino, G., de Keenoy, E. Manuel, Moda, G., Rodriguez-Mañas, L., Vontetsianos, T., Abreu, C., Alonso, J., Alonso-Bouzon, C., Ankri, J., Arredondo, M. T., Avolio, F., Bedbrook, A., Białoszewski, A. Z., Blain, H., Bourret, R., Cabrera-Umpierrez, M. F., Catala, A., O’Caoimh, R., Cesari, M., Chavannes, N. H., Correia-Da-Sousa, J., Dedeu, T., Ferrando, M., Ferri, M., Fokkens, W. J., Garcia-Lizana, F., Guérin, O., Hellings, P. W., Haahtela, T., Illario, M., Inzerilli, M. C., Lodrup Carlsen, K. C., Kardas, P., Keil, T., Maggio, M., Mendez-Zorrilla, A., Menditto, E., Mercier, J., Michel, J. P., Murray, R., Nogues, M., O’Byrne-Maguire, I., Pappa, D., Parent, A. S., Pastorino, M., Robalo-Cordeiro, C., Samolinski, B., Siciliano, P., Teixeira, A. M., Tsartara, S. I., Valiulis, A., Vandenplas, O., Vasankari, T., Vellas, B., Vollenbroek-Hutten, M., Wickman, M., Yorgancioglu, A., Zuberbier, T., Barbagallo, M., Canonica, G. W., Klimek, L., Maggi, S., Aberer, W., Akdis, C., Adcock, I. M., Agache, I., Albera, C., Alonso-Trujillo, F., Angel Guarcia, M., Annesi-Maesano, I., Apostolo, J., Arshad, S. H., Attalin, V., Avignon, A., Bachert, C., Baroni, I., Bel, E., Benson, M., Bescos, C., Blasi, F., Barbara, C., Bergmann, K. C., Bernard, P. L., Bonini, S., Bousquet, P. J., Branchini, B., Brightling, C. E., Bruguière, V., Bunu, C., Bush, A., Caimmi, D. P., Calderon, M. A., Canovas, G., Cardona, V., Carlsen, K. H., Cesario, A., Chkhartishvili, E., Chiron, R., Chivato, T., Chung, K. F., D’Angelantonio, M., de Carlo, G., Cholley, D., Chorin, F., Combe, B., Compas, B., Costa, D. J., Costa, E., Coste, O., Coupet, A. -L., Crepaldi, G., Custovic, A., Dahl, R., Dahlen, S. E., Demoly, P., Devillier, P., Didier, A., Dinh-Xuan, A. T., Djukanovic, R., Dokic, D., du Toit, G., Dubakiene, R., Dupeyron, A., Emuzyte, R., Fiocchi, A., Wagner, A., Fletcher, M., Fonseca, J., Fougère, B., Gamkrelidze, A., Garces, G., Garcia-Aymeric, J., Garcia-Zapirain, B., Gemicioğlu, B., Gouder, C., Hellquist-Dahl, B., Hermosilla-Gimeno, I., Héve, D., Holland, C., Humbert, M., Hyland, M., Johnston, S. L., Just, J., Jutel, M., Kaidashev, I. P., Kaitov, M., Kalayci, O., Kalyoncu, A. F., Keijser, W., Kerstjens, H., Knezović, J., Kowalski, M., Koppelman, G. H., Kotska, T., Kovac, M., Kull, I., Kuna, P., Kvedariene, V., Lepore, V., Macnee, W., Maggio, M., Magnan, A., Majer, I., Manning, P., Marcucci, M., Marti, T., Masoli, M., Melen, E., Miculinic, N., Mihaltan, F., Milenkovic, B., Millot-Keurinck, J., Mlinarić, H., Momas, I., Montefort, S., Morais-Almeida, M., Moreno-Casbas, T., Mösges, R., Mullol, J., Nadif, R., Nalin, M., Navarro-Pardo, E., Nekam, K., Ninot, G., Paccard, D., Pais, S., Palummeri, E., Panzner, P., Papadopoulos, N. K., Papanikolaou, C., Passalacqua, G., Pastor, E., Perrot, M., Plavec, D., Popov, T. A., Postma, D. S., Price, D., Raffort, N., Reuzeau, J. C., Robine, J. M., Rodenas, F., Robusto, F., Roche, N., Romano, A., Romano, V., Rosado-Pinto, J., Roubille, F., Ruiz, F., Ryan, D., Salcedo, T., Schmid-Grendelmeier, P., Schulz, H., Schunemann, H. J., Serrano, E., Sheikh, A., Shields, M., Siafakas, N., Scichilone, N., Siciliano, P., Skrindo, I., Smit, H. A., Sourdet, S., Sousa-Costa, E., Spranger, O., Sooronbaev, T., Sruk, V., Sterk, P. J., Todo-Bom, A., Touchon, J., Tramontano, D., Triggiani, M., Tsartara, S. I., Valero, A. L., Valovirta, E., van Ganse, E., van Hage, M., van den Berge, M., Vandenplas, O., Ventura, M. T., Vergara, I., Vezzani, G., Vidal, D., Viegi, G., Wagemann, M., Whalley, B., Wickman, M., Wilson, N., Yiallouros, P. K., Žagar, M., Zaidi, A., Zidarn, M., Hoogerwerf, E. J., Usero, J., Zuffada, R., Senn, A., and de Oliveira-Alves, B.
Published: 2023
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4. Early prenatal detection of LUTO is associated with increased risk of kidney transplantation - a multi-institutional trans-atlantic experience

Author: Richter, J., primary, Harper, L., additional, Pecorelli, S., additional, Good, H., additional, Dos Santos, J., additional, Shinar, S., additional, Van Mieghem, T., additional, Lorenzo, A.J., additional, and Rickard, M., additional
Published: 2024
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5. Appearance of the bladder on initial voiding cystogram in boys with PUV and its relation to pre and postnatal findings.

Author: Pecorelli, S., Ferdynus, C., Delmas, J., and Harper, L.
Published: 2024
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6. The Reverse ‘Glove-finger’ Technique for laparoscopic retrieval of appendix

Author: Siano, E., Tonegatti, L. G., Stern, M. V., Pecorelli, S., Montanaro, B., Boroni, G., and Alberti, D.
Published: 2020
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7. A KRAS variant is a biomarker of poor outcome, platinum chemotherapy resistance and a potential target for therapy in ovarian cancer

Author: Ratner, ES, Keane, FK, Lindner, R, Tassi, RA, Paranjape, T, Glasgow, M, Nallur, S, Deng, Y, Lu, L, Steele, L, Sand, S, Muller, R-U, Bignotti, E, Bellone, S, Boeke, M, Yao, X, Pecorelli, S, Ravaggi, A, Katsaros, D, Zelterman, D, Cristea, MC, Yu, H, Rutherford, TJ, Weitzel, JN, Neuhausen, SL, Schwartz, PE, Slack, FJ, Santin, AD, and Weidhaas, JB
Subjects: Ovarian Cancer, Genetics, Rare Diseases, Clinical Research, Cancer, 2.1 Biological and endogenous factors, Aetiology, 3' Untranslated Regions, Aged, Antineoplastic Combined Chemotherapy Protocols, BRCA1 Protein, BRCA2 Protein, Biomarkers, Tumor, Carboplatin, Cell Line, Tumor, Cell Survival, Drug Resistance, Neoplasm, Female, Genotype, Humans, Kaplan-Meier Estimate, Middle Aged, Multivariate Analysis, Mutation, Neoplasms, Glandular and Epithelial, Ovarian Neoplasms, Paclitaxel, Polymorphism, Single Nucleotide, Prognosis, Proto-Oncogene Proteins, Proto-Oncogene Proteins p21(ras), RNA Interference, Treatment Outcome, ras Proteins, platinum resistance, KRAS variant, ovarian cancer, outcome, Clinical Sciences, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract: Germline variants in the 3' untranslated region (3'UTR) of cancer genes disrupting microRNA (miRNA) regulation have recently been associated with cancer risk. A variant in the 3'UTR of the KRAS oncogene, referred to as the KRAS variant, is associated with both cancer risk and altered tumor biology. Here, we test the hypothesis that the KRAS variant can act as a biomarker of outcome in epithelial ovarian cancer (EOC), and investigate the cause of altered outcome in KRAS variant-positive EOC patients. As this variant seems to be associated with tumor biology, we additionally test the hypothesis that this variant can be directly targeted to impact cell survival. EOC patients with complete clinical data were genotyped for the KRAS variant and analyzed for outcome (n=536), response to neoadjuvant chemotherapy (n=125) and platinum resistance (n=306). Outcome was separately analyzed for women with known BRCA mutations (n=79). Gene expression was analyzed on a subset of tumors with available tissue. Cell lines were used to confirm altered sensitivity to chemotherapy associated with the KRAS variant. Finally, the KRAS variant was directly targeted through small-interfering RNA/miRNA oligonucleotides in cell lines and survival was measured. Postmenopausal EOC patients with the KRAS variant were significantly more likely to die of ovarian cancer by multivariate analysis (hazard ratio=1.67, 95% confidence interval: 1.09-2.57, P=0.019, n=279). Perhaps explaining this finding, EOC patients with the KRAS variant were significantly more likely to be platinum resistant (odds ratio=3.18, confidence interval: 1.31-7.72, P=0.0106, n=291). In addition, direct targeting of the KRAS variant led to a significant reduction in EOC cell growth and survival in vitro. These findings confirm the importance of the KRAS variant in EOC, and indicate that the KRAS variant is a biomarker of poor outcome in EOC likely due to platinum resistance. In addition, this study supports the hypothesis that these tumors have continued dependence on such 3'UTR lesions, and that direct targeting may be a viable future treatment approach.
Published: 2012

8. Human papillomavirus 9-valent vaccine for cancer prevention : a systematic review of the available evidence

Author: SIGNORELLI, C., ODONE, A., CIORBA, V., CELLA, P., AUDISIO, R. A., LOMBARDI, A., MARIANI, L., MENNINI, F. S., PECORELLI, S., REZZA, G., ZUCCOTTI, G.V., and PERACINO, A.
Published: 2017

9. Effects of irradiation on the expression of surface antigens in human ovarian cancer.

Author: Santin, AD, Hiserodt, JC, Fruehauf, J, DiSaia, PJ, Pecorelli, S, and Granger, GA
Subjects: Tumor Cells, Cultured, Humans, Carcinoma, Ovarian Neoplasms, Antigens, Neoplasm, Antigens, Surface, Dose-Response Relationship, Radiation, Kinetics, Gamma Rays, Female, Tumor Cells, Cultured, Antigens, Neoplasm, Surface, Dose-Response Relationship, Radiation, Cancer, Ovarian Cancer, Rare Diseases, 2.1 Biological and endogenous factors, Oncology & Carcinogenesis, Oncology and Carcinogenesis, Paediatrics and Reproductive Medicine
Abstract: Tumor cells from four established human ovarian carcinoma cell lines were analyzed for their expression of surface antigens including MHC Class I, Class II, ICAM-1, and the tumor-associated antigens CA 125 and Her2-neu before and after exposure to high doses of gamma irradiation. All four ovarian cell IInes expressed variable levels of MHC Class I and Her2-neu. ICAM-1 antigens were expressed in only two cell lines and Class II and CA 125 surface antigens were absent in all the cell lines evaluated. Exposure to high doses of gamma irradiation (i.e., 5000 to 10,000 cGy) significantly and consistently increased the expression of all surface antigens present on the cells prior to irradiation. Importantly, the irradiation-induced upregulation was persistent and lasted until all the cells died. Irradiation was unable to induce neoexpression of antigens previously not expressed by the cells (i.e., MHC Class II or ICAM-1). These findings may partially explain the increased immunogenicity of tumor cells following irradiation and may suggest enhanced immune recognition in tumor tissue in patients receiving radiation therapy.
Published: 1996

10. Effects of cytokines combined with high-dose gamma irradiation on the expression of major histocompatibility complex molecules and intercellular adhesion molecule-1 in human ovarian cancers.

Author: Santin, AD, Rose, GS, Hiserodt, JC, Fruehauf, J, Eck, LM, Garcia, RI, Schranz, V, Disaia, PJ, Pecorelli, S, and Granger, GA
Subjects: Humans, Adenocarcinoma, Ovarian Neoplasms, Tumor Necrosis Factor-alpha, Intercellular Adhesion Molecule-1, Histocompatibility Antigens Class I, Gamma Rays, Female, Interferon-gamma, Ovarian Cancer, Cancer, Human Genome, Genetics, Immunization, Rare Diseases, Vaccine Related, Inflammatory and Immune System, Oncology & Carcinogenesis, Oncology and Carcinogenesis
Abstract: Tumor cells from 7 freshly isolated human ovarian tumors and 2 continuous human ovarian cancer cell lines were analyzed for their surface expression of MHC class-1, class 11 and ICAM-1 surface antigens before and after exposure to gamma-irradiation and/or the cytokines TNF-alpha plus IFN-gamma. All 7 fresh tumors expressed high levels of MHC class 1 and 1CAM-1 antigens, and levels were markedly up-regulated after exposure to TNF-alpha plus IFN-gamma Similarly, class-11 antigens were either induced (3 out of 7 tumors) or significantly up-regulated by TNF-alpha plus IFN-gamma. Exposure to high doses of gamma-irradiation also increased the expression of MHC class-1 and ICAM-1 antigens, albeit to a modest degree. MHC class 1 and ICAM-1 antigens expression was much lower on continuous human ovarian cell lines than on the fresh tumors. Exposure of these cells to TNF-alpha plus IFN-gamma markedly up-regulated antigen expression to levels comparable to those expressed on the freshly isolated tumors. With the established ovarian cell lines, removal of cytokines caused a rapid down-regulation of antigen expression to basal levels within 6 days, while in the fresh tumors a low level of up-regulation was still present at this time. In contrast, exposure to cytokines followed by high-dose gamma-irradiation resulted in a highly significant and long-lasting expression of each surface antigen which was either up-regulated or induced by the cytokines. These data indicated that the combination of these modalities may be beneficial in generating optimal antigen expression for use of tumor cells in vaccine studies.
Published: 1996

11. Development and characterization of an interleukin-2-transduced human ovarian carcinoma tumor vaccine not expressing major histocompatibility complex molecules.

Author: Santin, AD, Ioli, GR, Hiserodt, JC, Manetta, A, Pecorelli, S, DiSaia, PJ, and Granger, GA
Subjects: Tumor Cells, Cultured, Animals, Mice, Inbred BALB C, Humans, Mice, Mice, Nude, Adenocarcinoma, Papillary, Ovarian Neoplasms, Receptor, erbB-2, Interleukin-2, Vaccines, Histocompatibility Antigens Class I, Transfection, Neoplasm Transplantation, Cytotoxicity, Immunologic, Female, Receptor, ErbB-2, interleukin-2, ovarian cancer, tumor vaccine, Tumor Cells, Cultured, Inbred BALB C, Nude, Adenocarcinoma, Papillary, Receptor, erbB-2, Cytotoxicity, Immunologic, ErbB-2, Obstetrics & Reproductive Medicine, Paediatrics and Reproductive Medicine
Abstract: ObjectiveWe initiated studies to develop cytokine-secreting human ovarian carcinoma cells for the purpose of using these cells as vaccines for the treatment of advanced epithelial ovarian cancer.Study designA human ovarian carcinoma cell line (UCI-107) was genetically engineered to secrete the cytokine interleukin-2 by retroviral-mediated gene transduction.ResultsOne clone, termed UCI-107A IL-2 AS, constitutively secreted high levels of interleukin-2 (i.e., 2000 to 2300 pg/ml/10(5) cells per 48 hours) for > 55 passages and 8 months of study. Unlike parental- and vector-transduced cells, UCI-107A IL-2 AS cells were aneuploid and failed to express major histocompatibility complex class I and HER2/neu surface antigens. UCI-107A IL-2 AS cells were highly resistant to killing by gamma irradiation and continued to produce high levels of interleukin-2 even after irradiation with 10,000 cGy. Balb/C nude mice injected intraperitoneally with UCI 107-A IL-2 AS cells survived significantly longer than control animals, with 25% of the animals totally rejecting their tumors. UCI-107A IL-2 AS was totally resistant to killing by fresh allogeneic peripheral blood lymphocytes in four hour chromium 51 release assays but induced high levels of killing in 72-hour long-term cytotoxic assays.ConclusionThe potential use of these interleukin-2-secreting ovarian carcinoma cells as vaccines for women with advance ovarian cancer will be discussed.
Published: 1996

12. Development and in vitro characterization of a GM-CSF secreting human ovarian carcinoma tumor vaccine.

Author: Santin, AD, Ioli, GR, Hiserodt, JC, Rose, GS, Graf, MR, Lander, JK, Disaia, PJ, Pecorelli, S, and Granger, GA
Subjects: CYTOKINE, GM-CSF, IMMUNOTHERAPY, OVARIAN CANCER, TUMOR VACCINE, Oncology & Carcinogenesis, Oncology and Carcinogenesis
Abstract: A human ovarian carcinoma cell line (UCI-107) was genetically engineered to secrete the cytokine granulocyte-macrophage colony stimulating factor (GM-CSF), by retroviral medicated gene transduction. This line was transduced with the LXSN retroviral vector containing the human GM-CSF gene and the neomycin resistance selection marker. Numerous GM-CSF secreting clones were randomly isolated and one clone, termed UCI-107M GM-CSF-MPS, extensively characterized. This clone was shown to constitutively secrete high levels of GM-CSF (ie 420-585 pg ml-1 105 cells-1 48 h-1 for over 35 passages and 6 months of study. Like the parental cell line UCI-107, UCI-107M GM-CSF-MPS cells expressed MHC class I and Her2/Neu surface antigens but did not express detectable MHC class II, ICAM-1 or CA-125. No change in the expression of these surface proteins was noted between the parental cells and this GM-CSF secreting clone. The morphology of UCI-107M GM-CSF-MPS did not differ from that of the parental or LXSN vector control cells; however, parental cells had a slightly faster growth rate than the transductants. UCI-107M GM-CSF-MPS was sensitive to gamma irradiation, since as little as 2500 rads killed the cells within 10 days of irradiation. However, even after higher doses of irradiation (ie 10000 rads), GM-CSF secretion continued in vitro until about day 8. Interestingly, irradiation induced up-regulation of the surface antigens previously expressed, and they remained up-regulated for as long as the cells remained viable. The potential use of these GM-CSF secreting ovarian carcinoma cells as vaccines for women with advanced ovarian cancer will be discussed.
Published: 1995

13. Building bridges for innovation in ageing: Synergies between action groups of the EIP on AHA

Author: Bousquet, Jean, Bewick, M., Cano, A., Eklund, P., Fico, G., Goswami, N., Guldemond, N. A., Henderson, D., Hinkema, M. J., Liotta, G., Mair, A., Molloy, W., Monaco, A., Monsonis-Paya, I., Nizinska, A., Papadopoulos, H., Pavlickova, A., Pecorelli, S., Prados-Torres, A., Roller-Wirnsberger, R. E., Somekh, D., Vera-Muñoz, C., Visser, F., Farrell, J., Malva, J., Andersen Ranberg, K., Camuzat, T., Carriazo, A. M., Crooks, G., Gutter, Z., Iaccarino, G., de Keenoy, E. Manuel, Moda, G., Rodriguez-Mañas, L., Vontetsianos, T., Abreu, C., Alonso, J., Alonso-Bouzon, C., Ankri, J., Arredondo, M. T., Avolio, F., Bedbrook, A., Białoszewski, A. Z., Blain, H., Bourret, R., Cabrera-Umpierrez, M. F., Catala, A., O’Caoimh, R., Cesari, M., Chavannes, N. H., Correia-Da-Sousa, J., Dedeu, T., Ferrando, M., Ferri, M., Fokkens, W. J., Garcia-Lizana, F., Guérin, O., Hellings, P. W., Haahtela, T., Illario, M., Inzerilli, M. C., Lodrup Carlsen, K. C., Kardas, P., Keil, T., Maggio, M., Mendez-Zorrilla, A., Menditto, E., Mercier, J., Michel, J. P., Murray, R., Nogues, M., O’Byrne-Maguire, I., Pappa, D., Parent, A. S., Pastorino, M., Robalo-Cordeiro, C., Samolinski, B., Siciliano, P., Teixeira, A. M., Tsartara, S. I., Valiulis, A., Vandenplas, O., Vasankari, T., Vellas, B., Vollenbroek-Hutten, M., Wickman, M., Yorgancioglu, A., Zuberbier, T., Barbagallo, M., Canonica, G. W., Klimek, L., Maggi, S., Aberer, W., Akdis, C., Adcock, I. M., Agache, I., Albera, C., Alonso-Trujillo, F., Angel Guarcia, M., Annesi-Maesano, I., Apostolo, J., Arshad, S. H., Attalin, V., Avignon, A., Bachert, C., Baroni, I., Bel, E., Benson, M., Bescos, C., Blasi, F., Barbara, C., Bergmann, K. C., Bernard, P. L., Bonini, S., Bousquet, P. J., Branchini, B., Brightling, C. E., Bruguière, V., Bunu, C., Bush, A., Caimmi, D. P., Calderon, M. A., Canovas, G., Cardona, V., Carlsen, K. H., Cesario, A., Chkhartishvili, E., Chiron, R., Chivato, T., Chung, K. F., D’Angelantonio, M., de Carlo, G., Cholley, D., Chorin, F., Combe, B., Compas, B., Costa, D. J., Costa, E., Coste, O., Coupet, A. -L., Crepaldi, G., Custovic, A., Dahl, R., Dahlen, S. E., Demoly, P., Devillier, P., Didier, A., Dinh-Xuan, A. T., Djukanovic, R., Dokic, D., du Toit, G., Dubakiene, R., Dupeyron, A., Emuzyte, R., Fiocchi, A., Wagner, A., Fletcher, M., Fonseca, J., Fougère, B., Gamkrelidze, A., Garces, G., Garcia-Aymeric, J., Garcia-Zapirain, B., Gemicioğlu, B., Gouder, C., Hellquist-Dahl, B., Hermosilla-Gimeno, I., Héve, D., Holland, C., Humbert, M., Hyland, M., Johnston, S. L., Just, J., Jutel, M., Kaidashev, I. P., Kaitov, M., Kalayci, O., Kalyoncu, A. F., Keijser, W., Kerstjens, H., Knezović, J., Kowalski, M., Koppelman, G. H., Kotska, T., Kovac, M., Kull, I., Kuna, P., Kvedariene, V., Lepore, V., Macnee, W., Maggio, M., Magnan, A., Majer, I., Manning, P., Marcucci, M., Marti, T., Masoli, M., Melen, E., Miculinic, N., Mihaltan, F., Milenkovic, B., Millot-Keurinck, J., Mlinarić, H., Momas, I., Montefort, S., Morais-Almeida, M., Moreno-Casbas, T., Mösges, R., Mullol, J., Nadif, R., Nalin, M., Navarro-Pardo, E., Nekam, K., Ninot, G., Paccard, D., Pais, S., Palummeri, E., Panzner, P., Papadopoulos, N. K., Papanikolaou, C., Passalacqua, G., Pastor, E., Perrot, M., Plavec, D., Popov, T. A., Postma, D. S., Price, D., Raffort, N., Reuzeau, J. C., Robine, J. M., Rodenas, F., Robusto, F., Roche, N., Romano, A., Romano, V., Rosado-Pinto, J., Roubille, F., Ruiz, F., Ryan, D., Salcedo, T., Schmid-Grendelmeier, P., Schulz, H., Schunemann, H. J., Serrano, E., Sheikh, A., Shields, M., Siafakas, N., Scichilone, N., Siciliano, P., Skrindo, I., Smit, H. A., Sourdet, S., Sousa-Costa, E., Spranger, O., Sooronbaev, T., Sruk, V., Sterk, P. J., Todo-Bom, A., Touchon, J., Tramontano, D., Triggiani, M., Tsartara, S. I., Valero, A. L., Valovirta, E., van Ganse, E., van Hage, M., van den Berge, M., Vandenplas, O., Ventura, M. T., Vergara, I., Vezzani, G., Vidal, D., Viegi, G., Wagemann, M., Whalley, B., Wickman, M., Wilson, N., Yiallouros, P. K., Žagar, M., Zaidi, A., Zidarn, M., Hoogerwerf, E. J., Usero, J., Zuffada, R., Senn, A., and de Oliveira-Alves, B.
Published: 2017
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14. Approccio anatomo-clinico alla patologia degli annessi

Author: Pecorelli, S., Odicino, F., Tisi, G., Olivetti, Lucio, and Grazioli, Luigi
Published: 2008
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15. Phase II of oral gimatecan in patients with recurrent epithelial ovarian, fallopian tube or peritoneal cancer, previously treated with platinum and taxanes

Author: Pecorelli, S., Ray-Coquard, I., Tredan, O., Colombo, N., Parma, G., Tisi, G., Katsaròs, D., Lhommé, C., Lissoni, A.A., Vermorken, J.B., du Bois, A., Poveda, A., Frigerio, L., Barbieri, P., Carminati, P., Brienza, S., and Guastalla, J.P.
Published: 2010
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16. Vincristin, Bleomycin, Mitomycin-C und Cisplatin als neoadjuvante Therapie bei der Strahlentherapie von Hochrisikopatientinnen mit Plattenepithelkarzinom der Cervix uteri

Author: van der Burg, M. E. L., Subandono, A. J., De Oliveira, C. F., Mangioni, C., Zola, P., Pecorelli, S., van Oosterom, A. T., Vermorken, J. B., Teufel, Günther, editor, Pfleiderer, Albrecht, editor, and Ladner, Hans-Adolf, editor
Published: 1990
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17. EORTC-GCCG Phase-II-Studien beim metastasierten Karzinom der Cervix uteri

Author: van der Burg, M. E. L., Mangioni, C., Pecorelli, S., Namer, M., George, M., Kobierska, A., Dalesio, O., Rotmensz, N., Vermorken, J. B., Teufel, Günther, editor, Pfleiderer, Albrecht, editor, and Ladner, Hans-Adolf, editor
Published: 1990
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18. Correlation between serological immune response analyzed by a new ELISA for HPV-16/18 E7 oncoprotein and clinical characteristics of cervical cancer patients

Author: Ravaggi, A., Romani, C., Pasinetti, B., Tassi, R. A., Bignotti, E., Bandiera, E., Odicino, F. E., Ragnoli, M., Donzelli, C., Falchetti, M., Calza, S., Santin, A. D., and Pecorelli, S.
Published: 2006
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19. 2004 consensus statements on the management of ovarian cancer: final document of the 3rd International Gynecologic Cancer Intergroup Ovarian Cancer Consensus Conference (GCIG OCCC 2004)

Author: du Bois, A., Quinn, M., Thigpen, T., Vermorken, J., Avall-Lundqvist, E., Bookman, M., Bowtell, D., Brady, M., Casado, A., Cervantes, A., Eisenhauer, E., Friedlaender, M., Fujiwara, K., Grenman, S., Guastalla, J. P., Harper, P., Hogberg, T., Kaye, S., Kitchener, H., Kristensen, G., Mannel, R., Meier, W., Miller, B., Neijt, J. P., Oza, A., Ozols, R., Parmar, M., Pecorelli, S., Pfisterer, J., Poveda, A., Provencher, D., Pujade-Lauraine, E., Randall, M., Rochon, J., Rustin, G., Sagae, S., Stehman, F., Stuart, G., Trimble, E., Vasey, P., Vergote, I., Verheijen, R., and Wagner, U.
Published: 2005

20. Integration of new or experimental treatment options and new approaches to clinical trials

Author: Quinn, M., Pfisterer, J., Avall-Lundqvist, E., Bookman, M., Bowtell, D., Casado, A., Cervantes, A., Grenman, S., Harper, P., Oza, A., Pecorelli, S., Pujade-Lauraine, E., Trimble, E., Vasey, P., and Wagner, U.
Published: 2005

21. Gestational Trophoblastic Neoplasia

Author: NGAN, HYS, ODICINO, F, MAISONNEUVE, P, CREASMAN, WT, BELLER, U, QUINN, MA, HEINTZ, APM, PECORELLI, S, and BENEDET, JL
Published: 2006
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22. Carcinoma of the Fallopian Tube

Author: HEINTZ, APM, ODICINO, F, MAISONNEUVE, P, QUINN, MA, BENEDET, JL, CREASMAN, WT, NGAN, HYS, PECORELLI, S, and BELLER, U
Published: 2006
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23. Carcinoma of the Ovary

Author: HEINTZ, APM, ODICINO, F, MAISONNEUVE, P, QUINN, MA, BENEDET, JL, CREASMAN, WT, NGAN, HYS, PECORELLI, S, and BELLER, U
Published: 2006
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24. Carcinoma of the Corpus Uteri

Author: CREASMAN, WT, ODICINO, F, MAISONNEUVE, P, QUINN, MA, BELLER, U, BENEDET, JL, HEINTZ, APM, NGAN, HYS, and PECORELLI, S
Published: 2006
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25. Carcinoma of the Vagina

Author: BELLER, U, BENEDET, JL, CREASMAN, WT, NGAN, HYS, QUINN, MA, MAISONNEUVE, P, PECORELLI, S, ODICINO, F, and HEINTZ, APM
Published: 2006
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26. Carcinoma of the Cervix Uteri

Author: QUINN, MA, BENEDET, JL, ODICINO, F, MAISONNEUVE, P, BELLER, U, CREASMAN, WT, HEINTZ, APM, NGAN, HYS, and PECORELLI, S
Published: 2006
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27. PCV153 HOW COSTLY IS POOR ADHERENCE TO PHARMACOLOGICAL TREATMENTS FOR CARDIOVASCULAR DISEASE? A SYSTEMATIC LITERATURE REVIEW

Author: Monaco, A., primary, Gracia, A., additional, Paz, S., additional, Costa, E., additional, Grobbee, D., additional, Giardini, A., additional, Montrasio, L., additional, Russo, P., additional, Bonassi, S., additional, and Pecorelli, S., additional
Published: 2019
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28. Systemic therapy for gynecological neoplasms: Ovary, cervix, and endometrium

Author: Pecorelli, S., primary, Pasinetti, B., additional, Angioli, R., additional, Favalli, G., additional, and Odicino, F., additional
Published: 2005
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29. HPV Vaccination Concepts in the Reality of Today

Author: Paderno, A, Garolla, A, Pecorelli, S, Lombardi, A, Pinto, C, Icardi, G, Bonetti, F, Mennini, F, Conversano, M, Isidori, A, Mariani, L, Rezza, G, and Peracino, A
Subjects: Settore SECS-P/03 - Scienza delle Finanze
Published: 2019

30. Systemic therapy for gynecological neoplasms: ovary, cervix and endometrium

Author: Pecorelli, S, primary, Angioli, R, additional, Favalli, G, additional, and Odicino, F, additional
Published: 2003
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31. International Collaborative Ovarian Neoplasm Trial 1 and Adjuvant ChemoTherapy In Ovarian Neoplasm Trial: Two Parallel Randomized Phase III Trials of Adjuvant Chemotherapy in Patients With Early-Stage Ovarian Carcinoma

Author: Trimbos, J. B., Parmar, M., Guthrie, D., Swart, A. M., Vergote, I., Bolis, G., Colombo, N., Vermorken, J. B., Torri, V., Mangioni, C., Lissoni, A., and Pecorelli, S.
Published: 2003

32. "AFTER SIX" maintenance protocol for advanced malignant epithelial tumors of the ovary after first-line treatment

Author: Conte, Pierfranco, Pecorelli, S, Favalli, G, and Nanni, M
Published: 2001

33. Cisplatin, doxorubicin and ifosfamide in carcinosarcoma of the female genital tract. A phase II study of the European Organization for Research and Treatment of Cancer Gynaecological Cancer Group (EORTC 55923)

Author: van Rijswijk, R.E.N., Vermorken, J.B., Reed, N., Favalli, G., Mendiola, C., Zanaboni, F., Mangili, G., Vergote, I., Guastalla, J.P., ten Bokkel Huinink, W.W., Lacave, A.J., Bonnefoi, H., Tumulo, S., Rietbroek, R., Teodorovic, I., Coens, C., and Pecorelli, S.
Published: 2003
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34. Cancer in women

Author: Pecorelli, S., Favalli, G., Zigliani, L., and Odicino, F.
Published: 2003
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35. Successful application of indirect in-situ polymerase chain reaction to tissues fixed in Bouin's solution

Author: Vigni, R Li, Bianchi, U A, Carosi, G, Lomini, M, Falchetti, M, Callea, F, and Pecorelli, S
Published: 1999

36. Neoadjuvant chemotherapy versus debulking surgery in advanced tubo-ovarian cancers: pooled analysis of individual patient data from the EORTC 55971 and CHORUS trials

Author: Vergote, Ignace, primary, Coens, Corneel, additional, Nankivell, Matthew, additional, Kristensen, Gunnar B, additional, Parmar, Mahesh K B, additional, Ehlen, Tom, additional, Jayson, Gordon C, additional, Johnson, Nick, additional, Swart, Ann Marie, additional, Verheijen, René, additional, McCluggage, W Glenn, additional, Perren, Tim, additional, Panici, Pierluigi Benedetti, additional, Kenter, Gemma, additional, Casado, Antonio, additional, Mendiola, Cesar, additional, Stuart, Gavin, additional, Reed, Nick S, additional, Kehoe, Sean, additional, Tropé G., Claes, additional, Dobbs, Stephen, additional, Essapen, Sharadah, additional, Hoskins, P., additional, Green, John, additional, Gilby, E., additional, Van Baal, M., additional, Twigg, Jeremy, additional, Van Der Burg, Maria E.L., additional, Godfrey, Keith, additional, Lacave, Angel J., additional, Angioli, R., additional, Nath, Rahul, additional, Chin, Kirk, additional, Redman, Charles, additional, Lotocki, R., additional, Olaitan, Adeola, additional, Mosgaard, B., additional, Rustin, G., additional, Ind, Thomas, additional, Persic, Mojca, additional, Hogg, Martin, additional, Van Der Velden, J., additional, Ledermann, J., additional, Peter Sykes, Peter Sykes, additional, Madhavan, Krishnawam, additional, Kannisto, P., additional, Hird, Vicky, additional, Evans, A., additional, Sandvei R., R., additional, Gauthier, P., additional, Cruickshank, D.J., additional, Ottevanger, P.B., additional, Pearson, Sheila, additional, Kitchener, Henry, additional, Hall, Marcia, additional, Bessette, P., additional, Pecorelli, S., additional, Gerdin, E., additional, Lopes, Tito, additional, Fish, Andrew, additional, Barlow., Clare, additional, Van Eygen, K., additional, Floquet, A., additional, Tholander, B., additional, Gul, N., additional, Gornall, Robert, additional, Luesley, David, additional, Kirwan, Philip, additional, Symonds, Paul, additional, Henry, Richard, additional, Poole, David, additional, McNeish, Ian, additional, Hocking, Mark, additional, Sammaraie, Al, additional, Speiser, P., additional, Leblanc, E., additional, Green, J.A., additional, De Oliveira, C.F., additional, Grimshaw, R., additional, Zola, P., additional, Parkin, David, additional, Lamb, Martin, additional, Hong, Anne, additional, Gillespie, Alan, additional, Hamid, Abdel, additional, Ahmed, Ahmed, additional, Plante, M., additional, De Valk, B., additional, Nordin, A., additional, Clamp, Andrew, additional, Perez, David, additional, Graham Dark, Graham Dark, additional, Ferguson, Michelle, additional, MacGregor, Carol, additional, Skailes, Geraldine, additional, Jones, Rachel, additional, Cawdell, G., additional, Leeson, Simon, additional, Elit, L., additional, Dittrich, C., additional, Gotlieb, W., additional, Cullimore, John, additional, Crosse, Barbara, additional, Ridley, Paul, additional, Head, Anthony, additional, Nieto, Joaquin, additional, Awwad, Saif, additional, Brinkmann, Dirk, additional, Eustace, Damian, additional, Hindley, Andrew, additional, Katsaros, D., additional, Popadiuk, C., additional, Kristeller, Tome, additional, Redman, C., additional, Chan, S., additional, Marth, C., additional, Yiannakis, Dennis, additional, Lankaster, Kate, additional, Beynon, Gareth, additional, Suhail, Anwar, additional, Indrajit, Fernando, additional, Quigley, Mary, additional, Adeyemi, Olu, additional, Lofts, Fiona, additional, McNally, Orla, additional, Tristam, Amanda, additional, Lee, Martin, additional, Counsell, R., additional, Gleeson, N., additional, Papadopoulos, A., additional, Maggino, T., additional, Honkoop, A., additional, Ghatage, P., additional, Vermorken, J.B., additional, De Greve, J., additional, Boman, K., additional, Petru, E, additional, and Amant, F., additional
Published: 2018
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37. Phase II study of mitomycin-C and cisplatin in disseminated, squamous cell carcinoma of the uterine cervix. A European Organization for Research and Treatment of Cancer (EORTC) Gynecological Cancer Group study

Author: Wagenaar, H.C., Pecorelli, S., Mangioni, C., van der Burg, M.E.L., Rotmensz, N., Anastasopoulou, A., Zola, P., Veenhof, C.H.N., Lacave, A.J., Neijt, J.P., van Oosterom, A.T., Einhorn, N., and Vermorken, J.B.
Published: 2001
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38. Bleomycin, Methotrexate, and CCNU in Locally Advanced or Recurrent, Inoperable, Squamous-Cell Carcinoma of the Vulva: An EORTC Gynaecological Cancer Cooperative Group Study

Author: Wagenaar, H.C., Colombo, N., Vergote, I., Hoctin-Boes, G., Zanetta, G., Pecorelli, S., Lacave, A.J., van Hoesel, Q., Cervantes, A., Bolis, G., Namer, M., Lhommé, C., Guastalla, J.P., Nooij, M.A., Poveda, A., Scotto di Palumbo, V., and Vermorken, J.B.
Published: 2001
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39. Building bridges for innovation in ageing: Synergies between action groups of the EIP on AHA

Author: Bousquet, J. Bewick, M. Cano, A. Eklund, P. Fico, G. Goswami, N. Guldemond, N.A. Henderson, D. Hinkema, M.J. Liotta, G. Mair, A. Molloy, W. Monaco, A. Monsonis-Paya, I. Nizinska, A. Papadopoulos, H. Pavlickova, A. Pecorelli, S. Prados-Torres, A. Roller-Wirnsberger, R.E. Somekh, D. Vera-Muñoz, C. Visser, F. Farrell, J. Malva, J. Andersen Ranberg, K. Camuzat, T. Carriazo, A.M. Crooks, G. Gutter, Z. Iaccarino, G. de Keenoy, E.M. Moda, G. Rodriguez-Mañas, L. Vontetsianos, T. Abreu, C. Alonso, J. Alonso-Bouzon, C. Ankri, J. Arredondo, M.T. Avolio, F. Bedbrook, A. Białoszewski, A.Z. Blain, H. Bourret, R. Cabrera-Umpierrez, M.F. Catala, A. O’Caoimh, R. Cesari, M. Chavannes, N.H. Correia-Da-Sousa, J. Dedeu, T. Ferrando, M. Ferri, M. Fokkens, W.J. Garcia-Lizana, F. Guérin, O. Hellings, P.W. Haahtela, T. Illario, M. Inzerilli, M.C. Lodrup Carlsen, K.C. Kardas, P. Keil, T. Maggio, M. Mendez-Zorrilla, A. Menditto, E. Mercier, J. Michel, J.P. Murray, R. Nogues, M. O’Byrne-Maguire, I. Pappa, D. Parent, A.S. Pastorino, M. Robalo-Cordeiro, C. Samolinski, B. Siciliano, P. Teixeira, A.M. Tsartara, S.I. Valiulis, A. Vandenplas, O. Vasankari, T. Vellas, B. Vollenbroek-Hutten, M. Wickman, M. Yorgancioglu, A. Zuberbier, T. Barbagallo, M. Canonica, G.W. Klimek, L. Maggi, S. Aberer, W. Akdis, C. Adcock, I.M. Agache, I. Albera, C. Alonso-Trujillo, F. Angel Guarcia, M. Annesi-Maesano, I. Apostolo, J. Arshad, S.H. Attalin, V. Avignon, A. Bachert, C. Baroni, I. Bel, E. Benson, M. Bescos, C. Blasi, F. Barbara, C. Bergmann, K.C. Bernard, P.L. Bonini, S. Bousquet, P.J. Branchini, B. Brightling, C.E. Bruguière, V. Bunu, C. Bush, A. Caimmi, D.P. Calderon, M.A. Canovas, G. Cardona, V. Carlsen, K.H. Cesario, A. Chkhartishvili, E. Chiron, R. Chivato, T. Chung, K.F. D’Angelantonio, M. de Carlo, G. Cholley, D. Chorin, F. Combe, B. Compas, B. Costa, D.J. Costa, E. Coste, O. Coupet, A.-L. Crepaldi, G. Custovic, A. Dahl, R. Dahlen, S.E. Demoly, P. Devillier, P. Didier, A. Dinh-Xuan, A.T. Djukanovic, R. Dokic, D. du Toit, G. Dubakiene, R. Dupeyron, A. Emuzyte, R. Fiocchi, A. Wagner, A. Fletcher, M. Fonseca, J. Fougère, B. Gamkrelidze, A. Garces, G. Garcia-Aymeric, J. Garcia-Zapirain, B. Gemicioğlu, B. Gouder, C. Hellquist-Dahl, B. Hermosilla-Gimeno, I. Héve, D. Holland, C. Humbert, M. Hyland, M. Johnston, S.L. Just, J. Jutel, M. Kaidashev, I.P. Kaitov, M. Kalayci, O. Kalyoncu, A.F. Keijser, W. Kerstjens, H. Knezović, J. Kowalski, M. Koppelman, G.H. Kotska, T. Kovac, M. Kull, I. Kuna, P. Kvedariene, V. Lepore, V. Macnee, W. Magnan, A. Majer, I. Manning, P. Marcucci, M. Marti, T. Masoli, M. Melen, E. Miculinic, N. Mihaltan, F. Milenkovic, B. Millot-Keurinck, J. Mlinarić, H. Momas, I. Montefort, S. Morais-Almeida, M. Moreno-Casbas, T. Mösges, R. Mullol, J. Nadif, R. Nalin, M. Navarro-Pardo, E. Nekam, K. Ninot, G. Paccard, D. Pais, S. Palummeri, E. Panzner, P. Papadopoulos, N.K. Papanikolaou, C. Passalacqua, G. Pastor, E. Perrot, M. Plavec, D. Popov, T.A. Postma, D.S. Price, D. Raffort, N. Reuzeau, J.C. Robine, J.M. Rodenas, F. Robusto, F. Roche, N. Romano, A. Romano, V. Rosado-Pinto, J. Roubille, F. Ruiz, F. Ryan, D. Salcedo, T. Schmid-Grendelmeier, P. Schulz, H. Schunemann, H.J. Serrano, E. Sheikh, A. Shields, M. Siafakas, N. Scichilone, N. Siciliano, P. Skrindo, I. Smit, H.A. Sourdet, S. Sousa-Costa, E. Spranger, O. Sooronbaev, T. Sruk, V. Sterk, P.J. Todo-Bom, A. Touchon, J. Tramontano, D. Triggiani, M. Valero, A.L. Valovirta, E. van Ganse, E. van Hage, M. van den Berge, M. Ventura, M.T. Vergara, I. Vezzani, G. Vidal, D. Viegi, G. Wagemann, M. Whalley, B. Wilson, N. Yiallouros, P.K. Žagar, M. Zaidi, A. Zidarn, M. Hoogerwerf, E.J. Usero, J. Zuffada, R. Senn, A. de Oliveira-Alves, B.
Abstract: The Strategic Implementation Plan of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) proposed six Action Groups. After almost three years of activity, many achievements have been obtained through commitments or collaborative work of the Action Groups. However, they have often worked in silos and, consequently, synergies between Action Groups have been proposed to strengthen the triple win of the EIP on AHA. The paper presents the methodology and current status of the Task Force on EIP on AHA synergies. Synergies are in line with the Action Groups’ new Renovated Action Plan (2016-2018) to ensure that their future objectives are coherent and fully connected. The outcomes and impact of synergies are using the Monitoring and Assessment Framework for the EIP on AHA (MAFEIP). Eight proposals for synergies have been approved by the Task Force: Five cross-cutting synergies which can be used for all current and future synergies as they consider overarching domains (appropriate polypharmacy, citizen empowerment, teaching and coaching on AHA, deployment of synergies to EU regions, Responsible Research and Innovation), and three cross-cutting synergies focussing on current Action Group activities (falls, frailty, integrated care and chronic respiratory diseases). © 2017, Serdi and Springer-Verlag France.
Published: 2017

40. Molecular basis of pharmacological therapy in Cushing’s disease

Author: Ferone, Diego, Pivonello, Claudia, Vitale, Giovanni, Zatelli, Maria Chiara, Colao, Annamaria, Pivonello, Rosario, Albiger, ABC Group: N., Ambrogio, A., Arnaldi, G., Arvat, E., Baldelli, R., Berardelli, R., Boscaro, M., Cannavo', Salvatore, Cavagnini, F., Corsello, S. M., Cozzolino, A., De Bartolomeis, A., De Leo, M., Di Minno, G., Di Somma, C., Esposito, K., Fabbrocini, G., Foresta, C., Galderisi, M., Giordano, C., Giugliano, D., Giustina, A., Grimaldi, F., Isidori, A. M., Jannini, E., F. Lombardo, L. Manetti, Mannelli, M., Mantero, F., Marone, G., Mazziotti, G., Moretti, S., Nazzari, E., Paragliola, R. M., Pasquali, R., Pecorelli, S., Pecori Giraldi, F., Reimondo, G., Scaroni, C., Scillitani, A., Simeoli, C., Stigliano, A., Toscano, V., Trementino, L., Ferone, D, Pivonello, Claudia, Vitale, G, Zatelli, Mc, Colao, Annamaria, and Pivonello, Rosario
Subjects: business.industry, Endocrinology, Diabetes and Metabolism, Humans, Hypothalamus, Pituitary ACTH Hypersecretion, Pituitary Gland, Receptors, Glucocorticoid, Disease, Cushing's disease, medicine.disease, Bioinformatics, Clinical trial, Endocrinology, Pituitary adenoma, Diabetes mellitus, Immunology, medicine, Endocrine system, business, Receptor, Glucocorticoid, medicine.drug
Abstract: Cushing's disease (CD) is a severe endocrine condition caused by an adrenocorticotropin (ACTH)-pro- ducing pituitary adenoma that chronically stimulates adrenocortical cortisol production and with potentially serious complications if not or inadequately treated. Active CD may produce a fourfold increase in mortality and is associated with significant morbidities. Moreover, excess mortality risk may persist even after CD treatment. Although predictors of risk in treated CD are not fully understood, the importance of early recognition and ade- quate treatment is well established. Surgery with resection of a pituitary adenoma is still the first line therapy, being successful in about 60-70 % of patients; however, recur- rence within 2-4 years may often occur. When surgery fails, medical treatment can reduce cortisol production and ameliorate clinical manifestations while more definitive therapy becomes effective. Compounds that target hypo- thalamic-pituitary axis, glucocorticoid synthesis or adre- nocortical function are currently used to control the deleterious effects of chronic glucocorticoid excess. In this review we describe and analyze the molecular basis of the drugs targeting the disease at central level, suppressing ACTH secretion, as well as at peripheral level, acting as adrenal inhibitors, or glucocorticoid receptor antagonists. Understanding of the underlying molecular mechanisms in CD and of glucocorticoid biology should promote the development of new targeted and more successful therapies in the future. Indeed, most of the drugs discussed have been tested in limited clinical trials, but there is potential ther- apeutic benefit in compounds with better specificity for the class of receptors expressed by ACTH-secreting tumors. However, long-term follow-up with management of per- sistent comorbidities is needed even after successful treatment of CD.
Published: 2013

41. Caring about women and cancer (CAWAC): a European survey of the perspectives and experiences of women with female cancers

Author: Veronesi, U., von Kleist, S., Redmond, K., Costa, A., Delvaux, N., Freilich, G., Glaus, A., Hudson, T., McVie, J.G., Macnamara, C., Meunier, F., Pecorelli, S., and Serin, D.
Published: 1999
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42. Building Bridges for Innovation in Ageing : Synergies between Action Groups of the EIP on AHA

Author: Bousquet, J, Bewick, M, Cano, A, Eklund, Patrik, Fico, G, Goswami, N, Guldemond, N A, Henderson, D, Hinkema, M J, Liotta, G, Mair, A, Molloy, W, Monaco, A, Monsonis-Paya, I, Nizinska, A, Papadopoulos, H, Pavlickova, A, Pecorelli, S, Prados-Torres, A, Roller-Wirnsberger, R E, Somekh, D, Vera-Muñoz, C, Visser, F, Farrell, J, Malva, J, Andersen Ranberg, K, Camuzat, T, Carriazo, A M, Crooks, G, Gutter, Z, Iaccarino, G, Manuel de Keenoy, E, Moda, G, Rodriguez-Mañas, L, Vontetsianos, T, Abreu, C, Alonso, J, Alonso-Bouzon, C, Ankri, J, Arredondo, M T, Avolio, F, Bedbrook, A, Białoszewski, A Z, Blain, H, Bourret, R, Cabrera-Umpierrez, M F, Catala, A, O'Caoimh, R, Cesari, M, Chavannes, N H, Correia-da-Sousa, J, Dedeu, T, Ferrando, M, Ferri, M, Fokkens, W J, Garcia-Lizana, F, Guérin, O, Hellings, P W, Haahtela, T, Illario, M, Inzerilli, M C, Lodrup Carlsen, K C, Kardas, P, Keil, T, Maggio, M, Mendez-Zorrilla, A, Menditto, E, Mercier, J, Michel, J P, Murray, R, Nogues, M, O'Byrne-Maguire, I, Pappa, D, Parent, A S, Pastorino, M, Robalo-Cordeiro, C, Samolinski, B, Siciliano, P, Teixeira, A M, Tsartara, S I, Valiulis, A, Vandenplas, O, Vasankari, T, Vellas, B, Vollenbroek-Hutten, M, Wickman, M, Yorgancioglu, A, Zuberbier, T, Barbagallo, M, Canonica, G W, Klimek, L, Maggi, S, Aberer, W, Akdis, C, Adcock, I M, Agache, I, Albera, C, Alonso-Trujillo, F, Angel Guarcia, M, Annesi-Maesano, I, Apostolo, J, Arshad, S H, Attalin, V, Avignon, A, Bachert, C, Baroni, I, Bel, E, Benson, M, Bescos, C, Blasi, F, Barbara, C, Bergmann, K C, Bernard, P L, Bonini, S, Bousquet, P J, Branchini, B, Brightling, C E, Bruguière, V, Bunu, C, Bush, A, Caimmi, D P, Calderon, M A, Canovas, G, Cardona, V, Carlsen, K H, Cesario, A, Chkhartishvili, E, Chiron, R, Chivato, T, Chung, K F, d'Angelantonio, M, De Carlo, G, Cholley, D, Chorin, F, Combe, B, Compas, B, Costa, D J, Costa, E, Coste, O, Coupet, A-L, Crepaldi, G, Custovic, A, Dahl, R, Dahlen, S E, Demoly, P, Devillier, P, Didier, A, Dinh-Xuan, A T, Djukanovic, R, Dokic, D, Du Toit, G, Dubakiene, R, Dupeyron, A, Emuzyte, R, Fiocchi, A, Wagner, A, Fletcher, M, Fonseca, J, Fougère, B, Gamkrelidze, A, Garces, G, Garcia-Aymeric, J, Garcia-Zapirain, B, Gemicioğlu, B, Gouder, C, Hellquist-Dahl, B, Hermosilla-Gimeno, I, Héve, D, Holland, C, Humbert, M, Hyland, M, Johnston, S L, Just, J, Jutel, M, Kaidashev, I P, Khaitov, M, Kalayci, O, Kalyoncu, A F, Keijser, W, Kerstjens, H, Knezović, J, Kowalski, M, Koppelman, G H, Kotska, T, Kovac, M, Kull, I, Kuna, P, Kvedariene, V, Lepore, V, MacNee, W, Magnan, A, Majer, I, Manning, P, Marcucci, M, Marti, T, Masoli, M, Melen, E, Miculinic, N, Mihaltan, F, Milenkovic, B, Millot-Keurinck, J, Mlinarić, H, Momas, I, Montefort, S, Morais-Almeida, M, Moreno-Casbas, T, Mösges, R, Mullol, J, Nadif, R, Nalin, M, Navarro-Pardo, E, Nekam, K, Ninot, G, Paccard, D, Pais, S, Palummeri, E, Panzner, P, Papadopoulos, N K, Papanikolaou, C, Passalacqua, G, Pastor, E, Perrot, M, Plavec, D, Popov, T A, Postma, D S, Price, D, Raffort, N, Reuzeau, J C, Robine, J M, Rodenas, F, Robusto, F, Roche, N, Romano, A, Romano, V, Rosado-Pinto, J, Roubille, F, Ruiz, F, Ryan, D, Salcedo, T, Schmid-Grendelmeier, P, Schulz, H, Schunemann, H J, Serrano, E, Sheikh, A, Shields, M, Siafakas, N, Scichilone, N, Skrindo, I, Smit, H A, Sourdet, S, Sousa-Costa, E, Spranger, O, Sooronbaev, T, Sruk, V, Sterk, P J, Todo-Bom, A, Touchon, J, Tramontano, D, Triggiani, M, Valero, A L, Valovirta, E, van Ganse, E, van Hage, M, van den Berge, M, Ventura, M T, Vergara, I, Vezzani, G, Vidal, D, Viegi, G, Wagemann, M, Whalley, B, Wilson, N, Yiallouros, P K, Žagar, M, Zaidi, A, Zidarn, M, Hoogerwerf, E J, Usero, J, Zuffada, R, Senn, A, de Oliveira-Alves, B, Bousquet, J, Bewick, M, Cano, A, Eklund, Patrik, Fico, G, Goswami, N, Guldemond, N A, Henderson, D, Hinkema, M J, Liotta, G, Mair, A, Molloy, W, Monaco, A, Monsonis-Paya, I, Nizinska, A, Papadopoulos, H, Pavlickova, A, Pecorelli, S, Prados-Torres, A, Roller-Wirnsberger, R E, Somekh, D, Vera-Muñoz, C, Visser, F, Farrell, J, Malva, J, Andersen Ranberg, K, Camuzat, T, Carriazo, A M, Crooks, G, Gutter, Z, Iaccarino, G, Manuel de Keenoy, E, Moda, G, Rodriguez-Mañas, L, Vontetsianos, T, Abreu, C, Alonso, J, Alonso-Bouzon, C, Ankri, J, Arredondo, M T, Avolio, F, Bedbrook, A, Białoszewski, A Z, Blain, H, Bourret, R, Cabrera-Umpierrez, M F, Catala, A, O'Caoimh, R, Cesari, M, Chavannes, N H, Correia-da-Sousa, J, Dedeu, T, Ferrando, M, Ferri, M, Fokkens, W J, Garcia-Lizana, F, Guérin, O, Hellings, P W, Haahtela, T, Illario, M, Inzerilli, M C, Lodrup Carlsen, K C, Kardas, P, Keil, T, Maggio, M, Mendez-Zorrilla, A, Menditto, E, Mercier, J, Michel, J P, Murray, R, Nogues, M, O'Byrne-Maguire, I, Pappa, D, Parent, A S, Pastorino, M, Robalo-Cordeiro, C, Samolinski, B, Siciliano, P, Teixeira, A M, Tsartara, S I, Valiulis, A, Vandenplas, O, Vasankari, T, Vellas, B, Vollenbroek-Hutten, M, Wickman, M, Yorgancioglu, A, Zuberbier, T, Barbagallo, M, Canonica, G W, Klimek, L, Maggi, S, Aberer, W, Akdis, C, Adcock, I M, Agache, I, Albera, C, Alonso-Trujillo, F, Angel Guarcia, M, Annesi-Maesano, I, Apostolo, J, Arshad, S H, Attalin, V, Avignon, A, Bachert, C, Baroni, I, Bel, E, Benson, M, Bescos, C, Blasi, F, Barbara, C, Bergmann, K C, Bernard, P L, Bonini, S, Bousquet, P J, Branchini, B, Brightling, C E, Bruguière, V, Bunu, C, Bush, A, Caimmi, D P, Calderon, M A, Canovas, G, Cardona, V, Carlsen, K H, Cesario, A, Chkhartishvili, E, Chiron, R, Chivato, T, Chung, K F, d'Angelantonio, M, De Carlo, G, Cholley, D, Chorin, F, Combe, B, Compas, B, Costa, D J, Costa, E, Coste, O, Coupet, A-L, Crepaldi, G, Custovic, A, Dahl, R, Dahlen, S E, Demoly, P, Devillier, P, Didier, A, Dinh-Xuan, A T, Djukanovic, R, Dokic, D, Du Toit, G, Dubakiene, R, Dupeyron, A, Emuzyte, R, Fiocchi, A, Wagner, A, Fletcher, M, Fonseca, J, Fougère, B, Gamkrelidze, A, Garces, G, Garcia-Aymeric, J, Garcia-Zapirain, B, Gemicioğlu, B, Gouder, C, Hellquist-Dahl, B, Hermosilla-Gimeno, I, Héve, D, Holland, C, Humbert, M, Hyland, M, Johnston, S L, Just, J, Jutel, M, Kaidashev, I P, Khaitov, M, Kalayci, O, Kalyoncu, A F, Keijser, W, Kerstjens, H, Knezović, J, Kowalski, M, Koppelman, G H, Kotska, T, Kovac, M, Kull, I, Kuna, P, Kvedariene, V, Lepore, V, MacNee, W, Magnan, A, Majer, I, Manning, P, Marcucci, M, Marti, T, Masoli, M, Melen, E, Miculinic, N, Mihaltan, F, Milenkovic, B, Millot-Keurinck, J, Mlinarić, H, Momas, I, Montefort, S, Morais-Almeida, M, Moreno-Casbas, T, Mösges, R, Mullol, J, Nadif, R, Nalin, M, Navarro-Pardo, E, Nekam, K, Ninot, G, Paccard, D, Pais, S, Palummeri, E, Panzner, P, Papadopoulos, N K, Papanikolaou, C, Passalacqua, G, Pastor, E, Perrot, M, Plavec, D, Popov, T A, Postma, D S, Price, D, Raffort, N, Reuzeau, J C, Robine, J M, Rodenas, F, Robusto, F, Roche, N, Romano, A, Romano, V, Rosado-Pinto, J, Roubille, F, Ruiz, F, Ryan, D, Salcedo, T, Schmid-Grendelmeier, P, Schulz, H, Schunemann, H J, Serrano, E, Sheikh, A, Shields, M, Siafakas, N, Scichilone, N, Skrindo, I, Smit, H A, Sourdet, S, Sousa-Costa, E, Spranger, O, Sooronbaev, T, Sruk, V, Sterk, P J, Todo-Bom, A, Touchon, J, Tramontano, D, Triggiani, M, Valero, A L, Valovirta, E, van Ganse, E, van Hage, M, van den Berge, M, Ventura, M T, Vergara, I, Vezzani, G, Vidal, D, Viegi, G, Wagemann, M, Whalley, B, Wilson, N, Yiallouros, P K, Žagar, M, Zaidi, A, Zidarn, M, Hoogerwerf, E J, Usero, J, Zuffada, R, Senn, A, and de Oliveira-Alves, B
Abstract: The Strategic Implementation Plan of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) proposed six Action Groups. After almost three years of activity, many achievements have been obtained through commitments or collaborative work of the Action Groups. However, they have often worked in silos and, consequently, synergies between Action Groups have been proposed to strengthen the triple win of the EIP on AHA. The paper presents the methodology and current status of the Task Force on EIP on AHA synergies. Synergies are in line with the Action Groups' new Renovated Action Plan (2016-2018) to ensure that their future objectives are coherent and fully connected. The outcomes and impact of synergies are using the Monitoring and Assessment Framework for the EIP on AHA (MAFEIP). Eight proposals for synergies have been approved by the Task Force: Five cross-cutting synergies which can be used for all current and future synergies as they consider overarching domains (appropriate polypharmacy, citizen empowerment, teaching and coaching on AHA, deployment of synergies to EU regions, Responsible Research and Innovation), and three cross-cutting synergies focussing on current Action Group activities (falls, frailty, integrated care and chronic respiratory diseases).
Published: 2017
Full Text: View/download PDF

43. Building bridges for innovation in ageing:synergies between action groups of the EIP on AHA

Author: Bousquet, Jean, Bewick, M., Cano, A., Eklund, P., Fico, G., Goswami, N., Guldemond, N. A., Henderson, D., Hinkema, M.J., Liotta, G., Mair, A., Molloy, W., Monaco, A., Monsonis-Paya, I., Nizinska, A., Papadopoulos, H., Pavlickova, A., Pecorelli, S., Prados-Torres, A., Roller-Wirnsberger, R.E., Somekh, D., Vera-Muñoz, C., Visser, F., Farrell, J., Malva, J., Andersen Ranberg, K., Camuzat, T., Carriazo, A.M., Crooks, G., Gutter, Z., Iaccarino, G., de Keenoy, E. Manuel, Moda, G., Rodriguez-Mañas, L., Vontetsianos, T., Abreu, C., Alonso, J., Alonso-Bouzon, C., Ankri, J., Arredondo, M.T., Avolio, F., Bedbrook, A., Białoszewski, A.Z., Blain, H., Bourret, R., Cabrera-Umpierrez, M.F., Catala, A., O’Caoimh, R., Cesari, M., Chavannes, N.H., Correia-da-Sousa, J., Dedeu, T., Ferrando, M., Ferri, M., Fokkens, W.J., Garcia-Lizana, F., Guérin, O., Hellings, P.W., Haahtela, T., Illario, M., Inzerilli, M.C., Lodrup Carlsen, K.C., Kardas, P., Keil, T., Maggio, M., Mendez-Zorrilla, A., Menditto, E., Mercier, J., Michel, J.P., Murray, R., Nogues, M., O’Byrne-Maguire, I., Pappa, D., Parent, A.S., Pastorino, M., Robalo-Cordeiro, C., Samolinski, B., Siciliano, P., Teixeira, A.M., Tsartara, S.I., Valiulis, A., Vandenplas, O., Vasankari, T., Vellas, B., Vollenbroek-Hutten, M., Wickman, M., Yorgancioglu, A., Zuberbier, T., Barbagallo, M., Canonica, G.W., Klimek, L., Maggi, S., Aberer, W., Akdis, C., Adcock, I.M., Agache, I., Albera, C., Alonso-Trujillo, F., Angel Guarcia, M., Annesi-Maesano, I., Apostolo, J., Arshad, S.H., Attalin, V., Avignon, A., Bachert, C., Baroni, I., Bel, E., Benson, M., Bescos, C., Blasi, F., Barbara, C., Bergmann, K.C., Bernard, P. L., Bonini, S., Bousquet, P.J., Branchini, B., Brightling, C.E., Bruguière, V., Bunu, C., Bush, A., Caimmi, D.P., Calderon, M. A., Canovas, G., Cardona, V., Carlsen, K.H., Cesario, A., Chkhartishvili, E., Chiron, R., Chivato, T., Chung, K.F., D’Angelantonio, M., de Carlo, G., Cholley, D., Chorin, F., Combe, B., Compas, B., Costa, D.J., Costa, E., Coste, O., Coupet, A.L., Crepaldi, G., Custovic, A., Dahl, R., Dahlen, S.E., Demoly, P., Devillier, P., Didier, A., Dinh-Xuan, A.T., Djukanovic, R., Dokic, D., du Toit, G., Dubakiene, R., Dupeyron, A., Emuzyte, R., Fiocchi, A., Wagner, A., Fletcher, M., Fonseca, J., Fougère, B., Gamkrelidze, A., Garces, G., Garcia-Aymeric, J., Garcia-Zapirain, B., Gemicioğlu, B., Gouder, C., Hellquist-Dahl, B., Hermosilla-Gimeno, I., Héve, D., Holland, C., Humbert, M., Hyland, M., Johnston, S.L., Just, J., Jutel, M., Kaidashev, I.P., Khaitov, M., Kalayci, O., Kalyoncu, A.F., Keijser, W., Kerstjens, H., Knezović, J., Kowalski, M., Koppelman, G.H., Kotska, T., Kovac, M., Kull, I., Kuna, P., Kvedariene, V., Lepore, V., Macnee, W., Magnan, A., Majer, I., Manning, P., Marcucci, M., Marti, T., Masoli, M., Melen, E., Miculinic, N., Mihaltan, F., Milenkovic, B., Millot-Keurinck, J., Mlinarić, H., Momas, I., Montefort, S., Morais-Almeida, M., Moreno-Casbas, T., Mösges, R., Mullol, J., Nadif, R., Nalin, M., Navarro-Pardo, E., Nekam, K., Ninot, G., Paccard, D., Pais, S., Palummeri, E., Panzner, P., Papadopoulos, N.K., Papanikolaou, C., Passalacqua, G., Pastor, E., Perrot, M., Plavec, D., Popov, T.A., Postma, D. S., Price, D., Raffort, N., Reuzeau, J.C., Robine, J.M., Rodenas, F., Robusto, F., Roche, N., Romano, A., Romano, V., Rosado-Pinto, J., Roubille, F., Ruiz, F., Ryan, D., Salcedo, T., Schmid-Grendelmeier, P., Schulz, H., Schunemann, H.J., Serrano, E., Sheikh, A., Shields, M., Siafakas, N., Scichilone, N., Skrindo, I., Smit, H. A., Sourdet, S., Sousa-Costa, E., Spranger, O., Sooronbaev, T., Sruk, V., Sterk, P. J., Todo-Bom, A., Touchon, J., Tramontano, D., Triggiani, M., Tsartara, S. I., Valero, A. L., Valovirta, E., van Ganse, E., van Hage, M., van Den Berge, M., Ventura, M. T., Vergara, I., Vezzani, G., Vidal, D., Viegi, G., Wagemann, M., Whalley, B., Wilson, N., Yiallouros, P. K., Žagar, M., Zaidi, A., Zidarn, M., Hoogerwerf, E. J., Usero, J., Zuffada, R., Senn, A., de Oliveira-Alves, B., Bousquet, Jean, Bewick, M., Cano, A., Eklund, P., Fico, G., Goswami, N., Guldemond, N. A., Henderson, D., Hinkema, M.J., Liotta, G., Mair, A., Molloy, W., Monaco, A., Monsonis-Paya, I., Nizinska, A., Papadopoulos, H., Pavlickova, A., Pecorelli, S., Prados-Torres, A., Roller-Wirnsberger, R.E., Somekh, D., Vera-Muñoz, C., Visser, F., Farrell, J., Malva, J., Andersen Ranberg, K., Camuzat, T., Carriazo, A.M., Crooks, G., Gutter, Z., Iaccarino, G., de Keenoy, E. Manuel, Moda, G., Rodriguez-Mañas, L., Vontetsianos, T., Abreu, C., Alonso, J., Alonso-Bouzon, C., Ankri, J., Arredondo, M.T., Avolio, F., Bedbrook, A., Białoszewski, A.Z., Blain, H., Bourret, R., Cabrera-Umpierrez, M.F., Catala, A., O’Caoimh, R., Cesari, M., Chavannes, N.H., Correia-da-Sousa, J., Dedeu, T., Ferrando, M., Ferri, M., Fokkens, W.J., Garcia-Lizana, F., Guérin, O., Hellings, P.W., Haahtela, T., Illario, M., Inzerilli, M.C., Lodrup Carlsen, K.C., Kardas, P., Keil, T., Maggio, M., Mendez-Zorrilla, A., Menditto, E., Mercier, J., Michel, J.P., Murray, R., Nogues, M., O’Byrne-Maguire, I., Pappa, D., Parent, A.S., Pastorino, M., Robalo-Cordeiro, C., Samolinski, B., Siciliano, P., Teixeira, A.M., Tsartara, S.I., Valiulis, A., Vandenplas, O., Vasankari, T., Vellas, B., Vollenbroek-Hutten, M., Wickman, M., Yorgancioglu, A., Zuberbier, T., Barbagallo, M., Canonica, G.W., Klimek, L., Maggi, S., Aberer, W., Akdis, C., Adcock, I.M., Agache, I., Albera, C., Alonso-Trujillo, F., Angel Guarcia, M., Annesi-Maesano, I., Apostolo, J., Arshad, S.H., Attalin, V., Avignon, A., Bachert, C., Baroni, I., Bel, E., Benson, M., Bescos, C., Blasi, F., Barbara, C., Bergmann, K.C., Bernard, P. L., Bonini, S., Bousquet, P.J., Branchini, B., Brightling, C.E., Bruguière, V., Bunu, C., Bush, A., Caimmi, D.P., Calderon, M. A., Canovas, G., Cardona, V., Carlsen, K.H., Cesario, A., Chkhartishvili, E., Chiron, R., Chivato, T., Chung, K.F., D’Angelantonio, M., de Carlo, G., Cholley, D., Chorin, F., Combe, B., Compas, B., Costa, D.J., Costa, E., Coste, O., Coupet, A.L., Crepaldi, G., Custovic, A., Dahl, R., Dahlen, S.E., Demoly, P., Devillier, P., Didier, A., Dinh-Xuan, A.T., Djukanovic, R., Dokic, D., du Toit, G., Dubakiene, R., Dupeyron, A., Emuzyte, R., Fiocchi, A., Wagner, A., Fletcher, M., Fonseca, J., Fougère, B., Gamkrelidze, A., Garces, G., Garcia-Aymeric, J., Garcia-Zapirain, B., Gemicioğlu, B., Gouder, C., Hellquist-Dahl, B., Hermosilla-Gimeno, I., Héve, D., Holland, C., Humbert, M., Hyland, M., Johnston, S.L., Just, J., Jutel, M., Kaidashev, I.P., Khaitov, M., Kalayci, O., Kalyoncu, A.F., Keijser, W., Kerstjens, H., Knezović, J., Kowalski, M., Koppelman, G.H., Kotska, T., Kovac, M., Kull, I., Kuna, P., Kvedariene, V., Lepore, V., Macnee, W., Magnan, A., Majer, I., Manning, P., Marcucci, M., Marti, T., Masoli, M., Melen, E., Miculinic, N., Mihaltan, F., Milenkovic, B., Millot-Keurinck, J., Mlinarić, H., Momas, I., Montefort, S., Morais-Almeida, M., Moreno-Casbas, T., Mösges, R., Mullol, J., Nadif, R., Nalin, M., Navarro-Pardo, E., Nekam, K., Ninot, G., Paccard, D., Pais, S., Palummeri, E., Panzner, P., Papadopoulos, N.K., Papanikolaou, C., Passalacqua, G., Pastor, E., Perrot, M., Plavec, D., Popov, T.A., Postma, D. S., Price, D., Raffort, N., Reuzeau, J.C., Robine, J.M., Rodenas, F., Robusto, F., Roche, N., Romano, A., Romano, V., Rosado-Pinto, J., Roubille, F., Ruiz, F., Ryan, D., Salcedo, T., Schmid-Grendelmeier, P., Schulz, H., Schunemann, H.J., Serrano, E., Sheikh, A., Shields, M., Siafakas, N., Scichilone, N., Skrindo, I., Smit, H. A., Sourdet, S., Sousa-Costa, E., Spranger, O., Sooronbaev, T., Sruk, V., Sterk, P. J., Todo-Bom, A., Touchon, J., Tramontano, D., Triggiani, M., Tsartara, S. I., Valero, A. L., Valovirta, E., van Ganse, E., van Hage, M., van Den Berge, M., Ventura, M. T., Vergara, I., Vezzani, G., Vidal, D., Viegi, G., Wagemann, M., Whalley, B., Wilson, N., Yiallouros, P. K., Žagar, M., Zaidi, A., Zidarn, M., Hoogerwerf, E. J., Usero, J., Zuffada, R., Senn, A., and de Oliveira-Alves, B.
Abstract: The Strategic Implementation Plan of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) proposed six Action Groups. After almost three years of activity, many achievements have been obtained through commitments or collaborative work of the Action Groups. However, they have often worked in silos and, consequently, synergies between Action Groups have been proposed to strengthen the triple win of the EIP on AHA. The paper presents the methodology and current status of the Task Force on EIP on AHA synergies. Synergies are in line with the Action Groups’ new Renovated Action Plan (2016-2018) to ensure that their future objectives are coherent and fully connected. The outcomes and impact of synergies are using the Monitoring and Assessment Framework for the EIP on AHA (MAFEIP). Eight proposals for synergies have been approved by the Task Force: Five cross-cutting synergies which can be used for all current and future synergies as they consider overarching domains (appropriate polypharmacy, citizen empowerment, teaching and coaching on AHA, deployment of synergies to EU regions, Responsible Research and Innovation), and three cross-cutting synergies focussing on current Action Group activities (falls, frailty, integrated care and chronic respiratory diseases).
Published: 2017

44. Building Bridges for Innovation in Ageing: Synergies between Action Groups of the EIP on AHA.

Author: UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (MGD) Service de pneumologie, Bousquet, J, Bewick, M, Cano, A, Eklund, P, Fico, G, Goswami, N, Guldemond, N A, Henderson, D, Hinkema, M J, Liotta, G, Mair, A, Molloy, W, Monaco, A, Monsonis-Paya, I, Nizinska, A, Papadopoulos, H, Pavlickova, A, Pecorelli, S, Prados-Torres, A, Roller-Wirnsberger, R E, Somekh, D, Vera-Muñoz, C, Visser, F, Farrell, J, Malva, J, Andersen Ranberg, K, Camuzat, T, Carriazo, A M, Crooks, G, Gutter, Z, Iaccarino, G, Manuel de Keenoy, E, Moda, G, Rodriguez-Mañas, L, Vontetsianos, T, Abreu, C, Alonso, J, Alonso-Bouzon, C, Ankri, J, Arredondo, M T, Avolio, F, Bedbrook, A, Białoszewski, A Z, Blain, H, Bourret, R, Cabrera-Umpierrez, M F, Catala, A, O'Caoimh, R, Cesari, M, Chavannes, N H, Correia-da-Sousa, J, Dedeu, T, Ferrando, M, Ferri, M, Fokkens, W J, Garcia-Lizana, F, Guérin, O, Hellings, P W, Haahtela, T, Illario, M, Inzerilli, M C, Lodrup Carlsen, K C, Kardas, P, Keil, T, Maggio, M, Mendez-Zorrilla, A, Menditto, E, Mercier, J, Michel, J P, Murray, R, Nogues, M, O'Byrne-Maguire, I, Pappa, D, Parent, A S, Pastorino, M, Robalo-Cordeiro, C, Samolinski, B, Siciliano, P, Teixeira, A M, Tsartara, S I, Valiulis, A, Vandenplas, Olivier, Vasankari, T, Vellas, B, Vollenbroek-Hutten, M, Wickman, M, Yorgancioglu, A, Zuberbier, T, Barbagallo, M, Canonica, G W, Klimek, L, Maggi, S, Aberer, W, Akdis, C, Adcock, I M, Agache, I, Albera, C, Alonso-Trujillo, F, Angel Guarcia, M, Annesi-Maesano, I, Apostolo, J, Arshad, S H, Attalin, V, Avignon, A, Bachert, C, Baroni, I, Bel, E, Benson, M, Bescos, C, Blasi, F, Barbara, C, Bergmann, K C, Bernard, P L, Bonini, S, Bousquet, P J, Branchini, B, Brightling, C E, Bruguière, V, Bunu, C, Bush, A, Caimmi, D P, Calderon, M A, Canovas, G, Cardona, V, Carlsen, K H, Cesario, A, Chkhartishvili, E, Chiron, R, Chivato, T, Chung, K F, d'Angelantonio, M, De Carlo, G, Cholley, D, Chorin, F, Combe, B, Compas, B, Costa, D J, Costa, E, Coste, O, Coupet, A-L, Crepaldi, G, Custovic, A, Dahl, R, Dahlen, S E, Demoly, P, Devillier, P, Didier, A, Dinh-Xuan, A T, Djukanovic, R, Dokic, D, Du Toit, G, Dubakiene, R, Dupeyron, A, Emuzyte, R, Fiocchi, A, Wagner, A, Fletcher, M, Fonseca, J, Fougère, B, Gamkrelidze, A, Garces, G, Garcia-Aymeric, J, Garcia-Zapirain, B, Gemicioğlu, B, Gouder, C, Hellquist-Dahl, B, Hermosilla-Gimeno, I, Héve, D, Holland, C, Humbert, M, Hyland, M, Johnston, S L, Just, J, Jutel, M, Kaidashev, I P, Khaitov, M, Kalayci, O, Kalyoncu, A F, Keijser, W, Kerstjens, H, Knezović, J, Kowalski, M, Koppelman, G H, Kotska, T, Kovac, M, Kull, I, Kuna, P, Kvedariene, V, Lepore, V, MacNee, W, Magnan, A, Majer, I, Manning, P, Marcucci, M, Marti, T, Masoli, M, Melen, E, Miculinic, N, Mihaltan, F, Milenkovic, B, Millot-Keurinck, J, Mlinarić, H, Momas, I, Montefort, S, Morais-Almeida, M, Moreno-Casbas, T, Mösges, R, Mullol, J, Nadif, R, Nalin, M, Navarro-Pardo, E, Nekam, K, Ninot, G, Paccard, D, Pais, S, Palummeri, E, Panzner, P, Papadopoulos, N K, Papanikolaou, C, Passalacqua, G, Pastor, E, Perrot, M, Plavec, D, Popov, T A, Postma, D S, Price, D, Raffort, N, Reuzeau, J C, Robine, J M, Rodenas, F, Robusto, F, Roche, N, Romano, A, Romano, V, Rosado-Pinto, J, Roubille, F, Ruiz, F, Ryan, D, Salcedo, T, Schmid-Grendelmeier, P, Schulz, H, Schunemann, H J, Serrano, E, Sheikh, A, Shields, M, Siafakas, N, Scichilone, N, Skrindo, I, Smit, H A, Sourdet, S, Sousa-Costa, E, Spranger, O, Sooronbaev, T, Sruk, V, Sterk, P J, Todo-Bom, A, Touchon, J, Tramontano, D, Triggiani, M, Valero, A L, Valovirta, E, van Ganse, E, van Hage, M, van den Berge, M, Vandenplas, O, Ventura, M T, Vergara, I, Vezzani, G, Vidal, D, Viegi, G, Wagemann, M, Whalley, B, Wilson, N, Yiallouros, P K, Žagar, M, Zaidi, A, Zidarn, M, Hoogerwerf, E J, Usero, J, Zuffada, R, Senn, A, de Oliveira-Alves, B, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (MGD) Service de pneumologie, Bousquet, J, Bewick, M, Cano, A, Eklund, P, Fico, G, Goswami, N, Guldemond, N A, Henderson, D, Hinkema, M J, Liotta, G, Mair, A, Molloy, W, Monaco, A, Monsonis-Paya, I, Nizinska, A, Papadopoulos, H, Pavlickova, A, Pecorelli, S, Prados-Torres, A, Roller-Wirnsberger, R E, Somekh, D, Vera-Muñoz, C, Visser, F, Farrell, J, Malva, J, Andersen Ranberg, K, Camuzat, T, Carriazo, A M, Crooks, G, Gutter, Z, Iaccarino, G, Manuel de Keenoy, E, Moda, G, Rodriguez-Mañas, L, Vontetsianos, T, Abreu, C, Alonso, J, Alonso-Bouzon, C, Ankri, J, Arredondo, M T, Avolio, F, Bedbrook, A, Białoszewski, A Z, Blain, H, Bourret, R, Cabrera-Umpierrez, M F, Catala, A, O'Caoimh, R, Cesari, M, Chavannes, N H, Correia-da-Sousa, J, Dedeu, T, Ferrando, M, Ferri, M, Fokkens, W J, Garcia-Lizana, F, Guérin, O, Hellings, P W, Haahtela, T, Illario, M, Inzerilli, M C, Lodrup Carlsen, K C, Kardas, P, Keil, T, Maggio, M, Mendez-Zorrilla, A, Menditto, E, Mercier, J, Michel, J P, Murray, R, Nogues, M, O'Byrne-Maguire, I, Pappa, D, Parent, A S, Pastorino, M, Robalo-Cordeiro, C, Samolinski, B, Siciliano, P, Teixeira, A M, Tsartara, S I, Valiulis, A, Vandenplas, Olivier, Vasankari, T, Vellas, B, Vollenbroek-Hutten, M, Wickman, M, Yorgancioglu, A, Zuberbier, T, Barbagallo, M, Canonica, G W, Klimek, L, Maggi, S, Aberer, W, Akdis, C, Adcock, I M, Agache, I, Albera, C, Alonso-Trujillo, F, Angel Guarcia, M, Annesi-Maesano, I, Apostolo, J, Arshad, S H, Attalin, V, Avignon, A, Bachert, C, Baroni, I, Bel, E, Benson, M, Bescos, C, Blasi, F, Barbara, C, Bergmann, K C, Bernard, P L, Bonini, S, Bousquet, P J, Branchini, B, Brightling, C E, Bruguière, V, Bunu, C, Bush, A, Caimmi, D P, Calderon, M A, Canovas, G, Cardona, V, Carlsen, K H, Cesario, A, Chkhartishvili, E, Chiron, R, Chivato, T, Chung, K F, d'Angelantonio, M, De Carlo, G, Cholley, D, Chorin, F, Combe, B, Compas, B, Costa, D J, Costa, E, Coste, O, Coupet, A-L, Crepaldi, G, Custovic, A, Dahl, R, Dahlen, S E, Demoly, P, Devillier, P, Didier, A, Dinh-Xuan, A T, Djukanovic, R, Dokic, D, Du Toit, G, Dubakiene, R, Dupeyron, A, Emuzyte, R, Fiocchi, A, Wagner, A, Fletcher, M, Fonseca, J, Fougère, B, Gamkrelidze, A, Garces, G, Garcia-Aymeric, J, Garcia-Zapirain, B, Gemicioğlu, B, Gouder, C, Hellquist-Dahl, B, Hermosilla-Gimeno, I, Héve, D, Holland, C, Humbert, M, Hyland, M, Johnston, S L, Just, J, Jutel, M, Kaidashev, I P, Khaitov, M, Kalayci, O, Kalyoncu, A F, Keijser, W, Kerstjens, H, Knezović, J, Kowalski, M, Koppelman, G H, Kotska, T, Kovac, M, Kull, I, Kuna, P, Kvedariene, V, Lepore, V, MacNee, W, Magnan, A, Majer, I, Manning, P, Marcucci, M, Marti, T, Masoli, M, Melen, E, Miculinic, N, Mihaltan, F, Milenkovic, B, Millot-Keurinck, J, Mlinarić, H, Momas, I, Montefort, S, Morais-Almeida, M, Moreno-Casbas, T, Mösges, R, Mullol, J, Nadif, R, Nalin, M, Navarro-Pardo, E, Nekam, K, Ninot, G, Paccard, D, Pais, S, Palummeri, E, Panzner, P, Papadopoulos, N K, Papanikolaou, C, Passalacqua, G, Pastor, E, Perrot, M, Plavec, D, Popov, T A, Postma, D S, Price, D, Raffort, N, Reuzeau, J C, Robine, J M, Rodenas, F, Robusto, F, Roche, N, Romano, A, Romano, V, Rosado-Pinto, J, Roubille, F, Ruiz, F, Ryan, D, Salcedo, T, Schmid-Grendelmeier, P, Schulz, H, Schunemann, H J, Serrano, E, Sheikh, A, Shields, M, Siafakas, N, Scichilone, N, Skrindo, I, Smit, H A, Sourdet, S, Sousa-Costa, E, Spranger, O, Sooronbaev, T, Sruk, V, Sterk, P J, Todo-Bom, A, Touchon, J, Tramontano, D, Triggiani, M, Valero, A L, Valovirta, E, van Ganse, E, van Hage, M, van den Berge, M, Vandenplas, O, Ventura, M T, Vergara, I, Vezzani, G, Vidal, D, Viegi, G, Wagemann, M, Whalley, B, Wilson, N, Yiallouros, P K, Žagar, M, Zaidi, A, Zidarn, M, Hoogerwerf, E J, Usero, J, Zuffada, R, Senn, A, and de Oliveira-Alves, B
Abstract: The Strategic Implementation Plan of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) proposed six Action Groups. After almost three years of activity, many achievements have been obtained through commitments or collaborative work of the Action Groups. However, they have often worked in silos and, consequently, synergies between Action Groups have been proposed to strengthen the triple win of the EIP on AHA. The paper presents the methodology and current status of the Task Force on EIP on AHA synergies. Synergies are in line with the Action Groups' new Renovated Action Plan (2016-2018) to ensure that their future objectives are coherent and fully connected. The outcomes and impact of synergies are using the Monitoring and Assessment Framework for the EIP on AHA (MAFEIP). Eight proposals for synergies have been approved by the Task Force: Five cross-cutting synergies which can be used for all current and future synergies as they consider overarching domains (appropriate polypharmacy, citizen empowerment, teaching and coaching on AHA, deployment of synergies to EU regions, Responsible Research and Innovation), and three cross-cutting synergies focussing on current Action Group activities (falls, frailty, integrated care and chronic respiratory diseases).
Published: 2017

45. BUILDING BRIDGES FOR INNOVATION IN AGEING: SYNERGIES BETWEEN ACTION GROUPS OF THE EIP ON AHA

Author: Bousquet, J., Bewick, M., Cano, A., Eklund, P., Fico, G., Goswami, N., Guldemond, N. A., Henderson, D., Hinkema, M. J., Liotta, G., Mair, A., Molloy, W., Monaco, A., Monsonis-Paya, I., Nizinska, A., Papadopoulos, H., Pavlickova, A., Pecorelli, S., Prados-Torres, A., Roller-Wirnsberger, R. E., Somekh, D., Vera-Munoz, C., Visser, F., Farrell, J., Malva, J., Ranberg, K. Andersen, Camuzat, T., Carriazo, A. M., Crooks, G., Gutter, Z., Iaccarino, G., Manuel De Keenoy, E., Moda, G., Rodriguez-Manas, L., Vontetsianos, T., Abreu, C., Alonso, J., Alonso-Bouzon, C., Ankri, J., Arredondo, M. T., Avolio, F., Bedbrook, A., Bialoszewski, A. Z., Blain, H., Bourret, R., Cabrera-Umpierrez, M. F., Catala, A., O'Caoimh, R., Cesari, M., Chavannes, N. H., Correia-Da-Sousa, J., Dedeu, T., Ferrando, M., Ferri, M., Fokkens, W. J., Garcia-Lizana, F., Guerin, O., Hellings, P. W., Haahtela, T., Illario, M., Inzerilli, M. C., Carlsen, K. C. Lodrup, Kardas, P., Keil, T., Maggio, M., Mendez-Zorrilla, A., Menditto, E., Mercier, J., Michel, J. P., Murray, R., Nogues, M., O'Byrne-Maguire, I., Pappa, D., Parent, A. S., Pastorino, M., Robalo-Cordeiro, C., Samolinski, B., Siciliano, P., Teixeira, A. M., Tsartara, S. I., Valiulis, A., Vandenplas, O., Vasankari, T., Vellas, B., Vollenbroek-Hutten, M., Wickman, M., Yorgancioglu, A., Zuberbier, T., Barbagallo, M., Canonica, G. W., Klimek, L., Maggi, S., Aberer, W., Akdis, C., Adcock, I. M., Agache, I., Albera, C., Alonso-Trujillo, F., Angel Guarcia, M., Annesi-Maesano, I., Apostolo, J., Arshad, S. H., Attalin, V., Avignon, A., Bachert, C., Baroni, I., Bel, E., Benson, M., Bescos, C., Blasi, F., Barbara, C., Bergmann, K. C., Bernard, P. L., Bonini, S., Bousquet, P. J., Branchini, B., Brightling, C. E., Bruguiere, V., Bunu, C., Bush, A., Caimmi, D. P., Calderon, M. A., Canovas, G., Cardona, V., Carlsen, K. H., Cesario, A., Chkhartishvili, E., Chiron, R., Chivato, T., Chung, K. F., D'Angelantonio, M., De Carlo, G., Cholley, D., Chorin, F., Combe, B., Compas, B., Costa, D. J., Costa, E., Coste, O., Coupet, A. -L., Crepaldi, G., Custovic, A., Dahl, R., Dahlen, S. E., Demoly, P., Devillier, P., Didier, A., Dinh-Xuan, A. T., Djukanovic, R., Dokic, D., Du Toit, G., Dubakiene, R., Dupeyron, A., Emuzyte, R., Fiocchi, A., Wagner, A., Fletcher, M., Fonseca, J., Fougere, B., Gamkrelidze, A., Garces, G., Garcia-Aymeric, J., Garcia-Zapirain, B., Gemicioglu, B., Gouder, C., Hellquist-Dahl, B., Hermosilla-Gimeno, I., Heve, D., Holland, C., Humbert, M., Hyland, M., Johnston, S. L., Just, J., Jutel, M., Kaidashev, I. P., Khaitov, M., Kalayci, O., Kalyoncu, A. F., Keijser, W., Kerstjens, H., Knezovic, J., Kowalski, M., Koppelman, G. H., Kotska, T., Kovac, M., Kull, I., Kuna, P., Kvedariene, V., Lepore, V., Macnee, W., Magnan, A., Majer, I., Manning, P., Marcucci, M., Marti, T., Masoli, M., Melen, E., Miculinic, N., Mihaltan, F., Milenkovic, B., Millot-Keurinck, J., Mlinaric, H., Momas, I., Montefort, S., Morais-Almeida, M., Moreno-Casbas, T., Moesges, R., Mullol, J., Nadif, R., Nalin, M., Navarro-Pardo, E., Nekam, K., Ninot, G., Paccard, D., Pais, S., Palummeri, E., Panzner, P., Papadopoulos, N. K., Papanikolaou, C., Passalacqua, G., Pastor, E., Perrot, M., Plavec, D., Popov, T. A., Postma, D. S., Price, D., Raffort, N., Reuzeau, J. C., Robine, J. M., Rodenas, F., Robusto, F., Roche, N., Romano, A., Romano, V., Rosado-Pinto, J., Roubille, F., Ruiz, F., Ryan, D., Salcedo, T., Schmid-Grendelmeier, P., Schulz, H., Schunemann, H. J., Serrano, E., Sheikh, A., Shields, M., Siafakas, N., Scichilone, N., Skrindo, I., Smit, H. A., Sourdet, S., Sousa-Costa, E., Spranger, O., Sooronbaev, T., Sruk, V., Sterk, P. J., Todo-Bom, A., Touchon, J., Tramontano, D., Triggiani, M., Valero, A. L., Valovirta, E., Van Ganse, E., Van Hage, M., Van den Berge, M., Ventura, M. T., Vergara, I., Vezzani, G., Vidal, D., Viegi, G., Wagemann, M., Whalley, B., Wilson, N., Yiallouros, P. K., Zagar, M., Zaidi, A., Zidarn, M., Hoogerwerf, E. J., Usero, J., Zuffada, R., Senn, A., De Oliveira-Alves, B., Bousquet, J., Bewick, M., Cano, A., Eklund, P., Fico, G., Goswami, N., Guldemond, N. A., Henderson, D., Hinkema, M. J., Liotta, G., Mair, A., Molloy, W., Monaco, A., Monsonis-Paya, I., Nizinska, A., Papadopoulos, H., Pavlickova, A., Pecorelli, S., Prados-Torres, A., Roller-Wirnsberger, R. E., Somekh, D., Vera-Munoz, C., Visser, F., Farrell, J., Malva, J., Ranberg, K. Andersen, Camuzat, T., Carriazo, A. M., Crooks, G., Gutter, Z., Iaccarino, G., Manuel De Keenoy, E., Moda, G., Rodriguez-Manas, L., Vontetsianos, T., Abreu, C., Alonso, J., Alonso-Bouzon, C., Ankri, J., Arredondo, M. T., Avolio, F., Bedbrook, A., Bialoszewski, A. Z., Blain, H., Bourret, R., Cabrera-Umpierrez, M. F., Catala, A., O'Caoimh, R., Cesari, M., Chavannes, N. H., Correia-Da-Sousa, J., Dedeu, T., Ferrando, M., Ferri, M., Fokkens, W. J., Garcia-Lizana, F., Guerin, O., Hellings, P. W., Haahtela, T., Illario, M., Inzerilli, M. C., Carlsen, K. C. Lodrup, Kardas, P., Keil, T., Maggio, M., Mendez-Zorrilla, A., Menditto, E., Mercier, J., Michel, J. P., Murray, R., Nogues, M., O'Byrne-Maguire, I., Pappa, D., Parent, A. S., Pastorino, M., Robalo-Cordeiro, C., Samolinski, B., Siciliano, P., Teixeira, A. M., Tsartara, S. I., Valiulis, A., Vandenplas, O., Vasankari, T., Vellas, B., Vollenbroek-Hutten, M., Wickman, M., Yorgancioglu, A., Zuberbier, T., Barbagallo, M., Canonica, G. W., Klimek, L., Maggi, S., Aberer, W., Akdis, C., Adcock, I. M., Agache, I., Albera, C., Alonso-Trujillo, F., Angel Guarcia, M., Annesi-Maesano, I., Apostolo, J., Arshad, S. H., Attalin, V., Avignon, A., Bachert, C., Baroni, I., Bel, E., Benson, M., Bescos, C., Blasi, F., Barbara, C., Bergmann, K. C., Bernard, P. L., Bonini, S., Bousquet, P. J., Branchini, B., Brightling, C. E., Bruguiere, V., Bunu, C., Bush, A., Caimmi, D. P., Calderon, M. A., Canovas, G., Cardona, V., Carlsen, K. H., Cesario, A., Chkhartishvili, E., Chiron, R., Chivato, T., Chung, K. F., D'Angelantonio, M., De Carlo, G., Cholley, D., Chorin, F., Combe, B., Compas, B., Costa, D. J., Costa, E., Coste, O., Coupet, A. -L., Crepaldi, G., Custovic, A., Dahl, R., Dahlen, S. E., Demoly, P., Devillier, P., Didier, A., Dinh-Xuan, A. T., Djukanovic, R., Dokic, D., Du Toit, G., Dubakiene, R., Dupeyron, A., Emuzyte, R., Fiocchi, A., Wagner, A., Fletcher, M., Fonseca, J., Fougere, B., Gamkrelidze, A., Garces, G., Garcia-Aymeric, J., Garcia-Zapirain, B., Gemicioglu, B., Gouder, C., Hellquist-Dahl, B., Hermosilla-Gimeno, I., Heve, D., Holland, C., Humbert, M., Hyland, M., Johnston, S. L., Just, J., Jutel, M., Kaidashev, I. P., Khaitov, M., Kalayci, O., Kalyoncu, A. F., Keijser, W., Kerstjens, H., Knezovic, J., Kowalski, M., Koppelman, G. H., Kotska, T., Kovac, M., Kull, I., Kuna, P., Kvedariene, V., Lepore, V., Macnee, W., Magnan, A., Majer, I., Manning, P., Marcucci, M., Marti, T., Masoli, M., Melen, E., Miculinic, N., Mihaltan, F., Milenkovic, B., Millot-Keurinck, J., Mlinaric, H., Momas, I., Montefort, S., Morais-Almeida, M., Moreno-Casbas, T., Moesges, R., Mullol, J., Nadif, R., Nalin, M., Navarro-Pardo, E., Nekam, K., Ninot, G., Paccard, D., Pais, S., Palummeri, E., Panzner, P., Papadopoulos, N. K., Papanikolaou, C., Passalacqua, G., Pastor, E., Perrot, M., Plavec, D., Popov, T. A., Postma, D. S., Price, D., Raffort, N., Reuzeau, J. C., Robine, J. M., Rodenas, F., Robusto, F., Roche, N., Romano, A., Romano, V., Rosado-Pinto, J., Roubille, F., Ruiz, F., Ryan, D., Salcedo, T., Schmid-Grendelmeier, P., Schulz, H., Schunemann, H. J., Serrano, E., Sheikh, A., Shields, M., Siafakas, N., Scichilone, N., Skrindo, I., Smit, H. A., Sourdet, S., Sousa-Costa, E., Spranger, O., Sooronbaev, T., Sruk, V., Sterk, P. J., Todo-Bom, A., Touchon, J., Tramontano, D., Triggiani, M., Valero, A. L., Valovirta, E., Van Ganse, E., Van Hage, M., Van den Berge, M., Ventura, M. T., Vergara, I., Vezzani, G., Vidal, D., Viegi, G., Wagemann, M., Whalley, B., Wilson, N., Yiallouros, P. K., Zagar, M., Zaidi, A., Zidarn, M., Hoogerwerf, E. J., Usero, J., Zuffada, R., Senn, A., and De Oliveira-Alves, B.
Abstract: The Strategic Implementation Plan of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) proposed six Action Groups. After almost three years of activity, many achievements have been obtained through commitments or collaborative work of the Action Groups. However, they have often worked in silos and, consequently, synergies between Action Groups have been proposed to strengthen the triple win of the EIP on AHA. The paper presents the methodology and current status of the Task Force on EIP on AHA synergies. Synergies are in line with the Action Groups' new Renovated Action Plan (2016-2018) to ensure that their future objectives are coherent and fully connected. The outcomes and impact of synergies are using the Monitoring and Assessment Framework for the EIP on AHA (MAFEIP). Eight proposals for synergies have been approved by the Task Force: Five cross-cutting synergies which can be used for all current and future synergies as they consider overarching domains (appropriate polypharmacy, citizen empowerment, teaching and coaching on AHA, deployment of synergies to EU regions, Responsible Research and Innovation), and three cross-cutting synergies focussing on current Action Group activities (falls, frailty, integrated care and chronic respiratory diseases).
Published: 2017

46. Building Bridges for Innovation in Ageing:Synergies between Action Groups of the EIP on AHA

Author: Bousquet, J, Bewick, M, Cano, A, Eklund, P, Fico, G, Goswami, N, Guldemond, N A, Henderson, D, Hinkema, M J, Liotta, G, Mair, A, Molloy, W, Monaco, A, Monsonis-Paya, I, Nizinska, A, Papadopoulos, H, Pavlickova, A, Pecorelli, S, Prados-Torres, A, Roller-Wirnsberger, R E, Somekh, D, Vera-Muñoz, C, Visser, F, Farrell, J, Malva, J, Andersen Ranberg, K, Camuzat, T, Carriazo, A M, Crooks, G, Gutter, Z, Iaccarino, G, Manuel de Keenoy, E, Moda, G, Rodriguez-Mañas, L, Vontetsianos, T, Abreu, C, Alonso, J, Alonso-Bouzon, C, Ankri, J, Arredondo, M T, Avolio, F, Bedbrook, A, Białoszewski, A Z, Blain, H, Bourret, R, Cabrera-Umpierrez, M F, Catala, A, O'Caoimh, R, Cesari, M, Chavannes, N H, Correia-da-Sousa, J, Dedeu, T, Ferrando, M, Fokkens, W J, Garcia-Lizana, F, Guérin, O, Hellings, P W, Haahtela, T, Illario, M, Inzerilli, M C, Lodrup Carlsen, K C, Kardas, P, Keil, T, Maggio, M, Mendez-Zorrilla, A, Menditto, E, Mercier, J, Michel, J P, Nogues, M, O'Byrne-Maguire, I, Pappa, D, Parent, A S, Pastorino, M, Robalo-Cordeiro, C, Samolinski, B, Siciliano, P, Teixeira, A M, Tsartara, S I, Valiulis, A, Vandenplas, O, Vasankari, T, Vellas, B, Vollenbroek-Hutten, M, Wickman, M, Yorgancioglu, A, Zuberbier, T, Barbagallo, M, Canonica, G W, Klimek, L, Maggi, S, Aberer, W, Akdis, C, Adcock, I M, Agache, I, Albera, C, Alonso-Trujillo, F, Angel Guarcia, M, Annesi-Maesano, I, Apostolo, J, Arshad, S H, Attalin, V, Avignon, A, Bachert, C, Baroni, I, Bel, E, Benson, M, Bescos, C, Blasi, F, Barbara, C, Bergmann, K C, Bernard, P L, Bonini, S, Bousquet, P J, Branchini, B, Brightling, C E, Bruguière, V, Bunu, C, Bush, A, Caimmi, D P, Canovas, G, Cardona, V, Carlsen, K H, Cesario, A, Chkhartishvili, E, Chiron, R, Chivato, T, Chung, K F, d'Angelantonio, M, De Carlo, G, Cholley, D, Chorin, F, Combe, B, Compas, B, Costa, D J, Costa, E, Coste, O, Coupet, A-L, Crepaldi, G, Custovic, A, Dahl, R, Dahlen, S E, Demoly, P, Devillier, P, Didier, A, Dinh-Xuan, A T, Djukanovic, R, Dokic, D, Du Toit, G, Dubakiene, R, Dupeyron, A, Emuzyte, R, Fiocchi, A, Wagner, A, Fletcher, M, Fonseca, J, Fougère, B, Gamkrelidze, A, Garces, G, Garcia-Aymeric, J, Garcia-Zapirain, B, Gemicioğlu, B, Gouder, C, Hellquist-Dahl, B, Hermosilla-Gimeno, I, Héve, D, Humbert, M, Hyland, M, Johnston, S L, Just, J, Jutel, M, Kaidashev, I P, Khaitov, M, Kalayci, O, Kalyoncu, A F, Keijser, W, Kerstjens, H, Knezović, J, Kowalski, M, Koppelman, G H, Kotska, T, Kovac, M, Kull, I, Kuna, P, Kvedariene, V, Lepore, V, MacNee, W, Magnan, A, Majer, I, Manning, P, Marcucci, M, Marti, T, Masoli, M, Melen, E, Miculinic, N, Mihaltan, F, Milenkovic, B, Millot-Keurinck, J, Mlinarić, H, Momas, I, Montefort, S, Morais-Almeida, M, Moreno-Casbas, T, Mösges, R, Mullol, J, Nadif, R, Nalin, M, Navarro-Pardo, E, Nekam, K, Ninot, G, Paccard, D, Pais, S, Palummeri, E, Panzner, P, Papadopoulos, N K, Papanikolaou, C, Passalacqua, G, Pastor, E, Perrot, M, Plavec, D, Popov, T A, Postma, D S, Raffort, N, Reuzeau, J C, Robine, J M, Rodenas, F, Robusto, F, Roche, N, Romano, A, Romano, V, Rosado-Pinto, J, Roubille, F, Ruiz, F, Ryan, D, Salcedo, T, Schmid-Grendelmeier, P, Schulz, H, Schunemann, H J, Serrano, E, Sheikh, A, Siafakas, N, Scichilone, N, Skrindo, I, Smit, H A, Sourdet, S, Sousa-Costa, E, Spranger, O, Sooronbaev, T, Sruk, V, Sterk, P J, Todo-Bom, A, Touchon, J, Tramontano, D, Triggiani, M, Valero, A L, Valovirta, E, van Ganse, E, van Hage, M, van den Berge, M, Ventura, M T, Vergara, I, Vezzani, G, Vidal, D, Viegi, G, Wagemann, M, Whalley, B, Yiallouros, P K, Žagar, M, Zaidi, A, Zidarn, M, Hoogerwerf, E J, Usero, J, Zuffada, R, Senn, A, de Oliveira-Alves, B, Holland, Carol Ann, Bousquet, J, Bewick, M, Cano, A, Eklund, P, Fico, G, Goswami, N, Guldemond, N A, Henderson, D, Hinkema, M J, Liotta, G, Mair, A, Molloy, W, Monaco, A, Monsonis-Paya, I, Nizinska, A, Papadopoulos, H, Pavlickova, A, Pecorelli, S, Prados-Torres, A, Roller-Wirnsberger, R E, Somekh, D, Vera-Muñoz, C, Visser, F, Farrell, J, Malva, J, Andersen Ranberg, K, Camuzat, T, Carriazo, A M, Crooks, G, Gutter, Z, Iaccarino, G, Manuel de Keenoy, E, Moda, G, Rodriguez-Mañas, L, Vontetsianos, T, Abreu, C, Alonso, J, Alonso-Bouzon, C, Ankri, J, Arredondo, M T, Avolio, F, Bedbrook, A, Białoszewski, A Z, Blain, H, Bourret, R, Cabrera-Umpierrez, M F, Catala, A, O'Caoimh, R, Cesari, M, Chavannes, N H, Correia-da-Sousa, J, Dedeu, T, Ferrando, M, Fokkens, W J, Garcia-Lizana, F, Guérin, O, Hellings, P W, Haahtela, T, Illario, M, Inzerilli, M C, Lodrup Carlsen, K C, Kardas, P, Keil, T, Maggio, M, Mendez-Zorrilla, A, Menditto, E, Mercier, J, Michel, J P, Nogues, M, O'Byrne-Maguire, I, Pappa, D, Parent, A S, Pastorino, M, Robalo-Cordeiro, C, Samolinski, B, Siciliano, P, Teixeira, A M, Tsartara, S I, Valiulis, A, Vandenplas, O, Vasankari, T, Vellas, B, Vollenbroek-Hutten, M, Wickman, M, Yorgancioglu, A, Zuberbier, T, Barbagallo, M, Canonica, G W, Klimek, L, Maggi, S, Aberer, W, Akdis, C, Adcock, I M, Agache, I, Albera, C, Alonso-Trujillo, F, Angel Guarcia, M, Annesi-Maesano, I, Apostolo, J, Arshad, S H, Attalin, V, Avignon, A, Bachert, C, Baroni, I, Bel, E, Benson, M, Bescos, C, Blasi, F, Barbara, C, Bergmann, K C, Bernard, P L, Bonini, S, Bousquet, P J, Branchini, B, Brightling, C E, Bruguière, V, Bunu, C, Bush, A, Caimmi, D P, Canovas, G, Cardona, V, Carlsen, K H, Cesario, A, Chkhartishvili, E, Chiron, R, Chivato, T, Chung, K F, d'Angelantonio, M, De Carlo, G, Cholley, D, Chorin, F, Combe, B, Compas, B, Costa, D J, Costa, E, Coste, O, Coupet, A-L, Crepaldi, G, Custovic, A, Dahl, R, Dahlen, S E, Demoly, P, Devillier, P, Didier, A, Dinh-Xuan, A T, Djukanovic, R, Dokic, D, Du Toit, G, Dubakiene, R, Dupeyron, A, Emuzyte, R, Fiocchi, A, Wagner, A, Fletcher, M, Fonseca, J, Fougère, B, Gamkrelidze, A, Garces, G, Garcia-Aymeric, J, Garcia-Zapirain, B, Gemicioğlu, B, Gouder, C, Hellquist-Dahl, B, Hermosilla-Gimeno, I, Héve, D, Humbert, M, Hyland, M, Johnston, S L, Just, J, Jutel, M, Kaidashev, I P, Khaitov, M, Kalayci, O, Kalyoncu, A F, Keijser, W, Kerstjens, H, Knezović, J, Kowalski, M, Koppelman, G H, Kotska, T, Kovac, M, Kull, I, Kuna, P, Kvedariene, V, Lepore, V, MacNee, W, Magnan, A, Majer, I, Manning, P, Marcucci, M, Marti, T, Masoli, M, Melen, E, Miculinic, N, Mihaltan, F, Milenkovic, B, Millot-Keurinck, J, Mlinarić, H, Momas, I, Montefort, S, Morais-Almeida, M, Moreno-Casbas, T, Mösges, R, Mullol, J, Nadif, R, Nalin, M, Navarro-Pardo, E, Nekam, K, Ninot, G, Paccard, D, Pais, S, Palummeri, E, Panzner, P, Papadopoulos, N K, Papanikolaou, C, Passalacqua, G, Pastor, E, Perrot, M, Plavec, D, Popov, T A, Postma, D S, Raffort, N, Reuzeau, J C, Robine, J M, Rodenas, F, Robusto, F, Roche, N, Romano, A, Romano, V, Rosado-Pinto, J, Roubille, F, Ruiz, F, Ryan, D, Salcedo, T, Schmid-Grendelmeier, P, Schulz, H, Schunemann, H J, Serrano, E, Sheikh, A, Siafakas, N, Scichilone, N, Skrindo, I, Smit, H A, Sourdet, S, Sousa-Costa, E, Spranger, O, Sooronbaev, T, Sruk, V, Sterk, P J, Todo-Bom, A, Touchon, J, Tramontano, D, Triggiani, M, Valero, A L, Valovirta, E, van Ganse, E, van Hage, M, van den Berge, M, Ventura, M T, Vergara, I, Vezzani, G, Vidal, D, Viegi, G, Wagemann, M, Whalley, B, Yiallouros, P K, Žagar, M, Zaidi, A, Zidarn, M, Hoogerwerf, E J, Usero, J, Zuffada, R, Senn, A, de Oliveira-Alves, B, and Holland, Carol Ann
Abstract: The Strategic Implementation Plan of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) proposed six Action Groups. After almost three years of activity, many achievements have been obtained through commitments or collaborative work of the Action Groups. However, they have often worked in silos and, consequently, synergies between Action Groups have been proposed to strengthen the triple win of the EIP on AHA. The paper presents the methodology and current status of the Task Force on EIP on AHA synergies. Synergies are in line with the Action Groups' new Renovated Action Plan (2016-2018) to ensure that their future objectives are coherent and fully connected. The outcomes and impact of synergies are using the Monitoring and Assessment Framework for the EIP on AHA (MAFEIP). Eight proposals for synergies have been approved by the Task Force: Five cross-cutting synergies which can be used for all current and future synergies as they consider overarching domains (appropriate polypharmacy, citizen empowerment, teaching and coaching on AHA, deployment of synergies to EU regions, Responsible Research and Innovation), and three cross-cutting synergies focussing on current Action Group activities (falls, frailty, integrated care and chronic respiratory diseases).
Published: 2017

47. Building Bridges for Innovation in Ageing: Synergies between Action Groups of the EIP on AHA

Author: CMM USEQ Facility, Circulatory Health, Child Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Public Health Epidemiologie, Bousquet, J, Bewick, M, Cano, A, Eklund, P, Fico, G, Goswami, N, Guldemond, N A, Henderson, D, Hinkema, M J, Liotta, G, Mair, A, Molloy, W, Monaco, A, Monsonis-Paya, I, Nizinska, A, Papadopoulos, H, Pavlickova, A, Pecorelli, S, Prados-Torres, A, Roller-Wirnsberger, R E, Somekh, D, Vera-Muñoz, C, Visser, F, Farrell, J, Malva, J, Andersen Ranberg, K, Camuzat, T, Carriazo, A M, Crooks, G, Gutter, Z, Iaccarino, G, Manuel de Keenoy, E, Moda, G, Rodriguez-Mañas, L, Vontetsianos, T, Abreu, C, Alonso, J, Alonso-Bouzon, C, Ankri, J, Arredondo, M T, Avolio, F, Bedbrook, A, Białoszewski, A Z, Blain, H, Bourret, R, Cabrera-Umpierrez, M F, Catala, A, O'Caoimh, R, Cesari, M, Chavannes, N H, Correia-da-Sousa, J, Dedeu, T, Ferrando, M, Ferri, M, Fokkens, W J, Garcia-Lizana, F, Guérin, O, Hellings, P W, Haahtela, T, Illario, M, Inzerilli, M C, Lodrup Carlsen, K C, Kardas, P, Keil, T, Maggio, M, Mendez-Zorrilla, A, Menditto, E, Mercier, J, Michel, J P, Murray, R, Nogues, M, O'Byrne-Maguire, I, Pappa, D, Parent, A S, Pastorino, M, Robalo-Cordeiro, C, Samolinski, B, Siciliano, P, Teixeira, A M, Tsartara, S I, Valiulis, A, Vandenplas, O, Vasankari, T, Vellas, B, Vollenbroek-Hutten, M, Wickman, M, Yorgancioglu, A, Zuberbier, T, Barbagallo, M, Canonica, G W, Klimek, L, Maggi, S, Aberer, W, Akdis, C, Adcock, I M, Agache, I, Albera, C, Alonso-Trujillo, F, Angel Guarcia, M, Annesi-Maesano, I, Apostolo, J, Arshad, S H, Attalin, V, Avignon, A, Bachert, C, Baroni, I, Bel, E, Benson, M, Bescos, C, Blasi, F, Barbara, C, Bergmann, K C, Bernard, P L, Bonini, S, Bousquet, P J, Branchini, B, Brightling, C E, Bruguière, V, Bunu, C, Bush, A, Caimmi, D P, Calderon, M A, Canovas, G, Cardona, V, Carlsen, K H, Cesario, A, Chkhartishvili, E, Chiron, R, Chivato, T, Chung, K F, d'Angelantonio, M, De Carlo, G, Cholley, D, Chorin, F, Combe, B, Compas, B, Costa, D J, Costa, E, Coste, O, Coupet, A-L, Crepaldi, G, Custovic, A, Dahl, R, Dahlen, S E, Demoly, P, Devillier, P, Didier, A, Dinh-Xuan, A T, Djukanovic, R, Dokic, D, Du Toit, G, Dubakiene, R, Dupeyron, A, Emuzyte, R, Fiocchi, A, Wagner, A, Fletcher, M, Fonseca, J, Fougère, B, Gamkrelidze, A, Garces, G, Garcia-Aymeric, J, Garcia-Zapirain, B, Gemicioğlu, B, Gouder, C, Hellquist-Dahl, B, Hermosilla-Gimeno, I, Héve, D, Holland, C, Humbert, M, Hyland, M, Johnston, S L, Just, J, Jutel, M, Kaidashev, I P, Khaitov, M, Kalayci, O, Kalyoncu, A F, Keijser, W, Kerstjens, H, Knezović, J, Kowalski, M, Koppelman, G H, Kotska, T, Kovac, M, Kull, I, Kuna, P, Kvedariene, V, Lepore, V, MacNee, W, Magnan, A, Majer, I, Manning, P, Marcucci, M, Marti, T, Masoli, M, Melen, E, Miculinic, N, Mihaltan, F, Milenkovic, B, Millot-Keurinck, J, Mlinarić, H, Momas, I, Montefort, S, Morais-Almeida, M, Moreno-Casbas, T, Mösges, R, Mullol, J, Nadif, R, Nalin, M, Navarro-Pardo, E, Nekam, K, Ninot, G, Paccard, D, Pais, S, Palummeri, E, Panzner, P, Papadopoulos, N K, Papanikolaou, C, Passalacqua, G, Pastor, E, Perrot, M, Plavec, D, Popov, T A, Postma, D S, Price, D, Raffort, N, Reuzeau, J C, Robine, J M, Rodenas, F, Robusto, F, Roche, N, Romano, A, Romano, V, Rosado-Pinto, J, Roubille, F, Ruiz, F, Ryan, D, Salcedo, T, Schmid-Grendelmeier, P, Schulz, H, Schunemann, H J, Serrano, E, Sheikh, A, Shields, M, Siafakas, N, Scichilone, N, Skrindo, I, Smit, H A, Sourdet, S, Sousa-Costa, E, Spranger, O, Sooronbaev, T, Sruk, V, Sterk, P J, Todo-Bom, A, Touchon, J, Tramontano, D, Triggiani, M, Valero, A L, Valovirta, E, van Ganse, E, van Hage, M, van den Berge, M, Ventura, M T, Vergara, I, Vezzani, G, Vidal, D, Viegi, G, Wagemann, M, Whalley, B, Wilson, N, Yiallouros, P K, Žagar, M, Zaidi, A, Zidarn, M, Hoogerwerf, E J, Usero, J, Zuffada, R, Senn, A, de Oliveira-Alves, B, CMM USEQ Facility, Circulatory Health, Child Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Public Health Epidemiologie, Bousquet, J, Bewick, M, Cano, A, Eklund, P, Fico, G, Goswami, N, Guldemond, N A, Henderson, D, Hinkema, M J, Liotta, G, Mair, A, Molloy, W, Monaco, A, Monsonis-Paya, I, Nizinska, A, Papadopoulos, H, Pavlickova, A, Pecorelli, S, Prados-Torres, A, Roller-Wirnsberger, R E, Somekh, D, Vera-Muñoz, C, Visser, F, Farrell, J, Malva, J, Andersen Ranberg, K, Camuzat, T, Carriazo, A M, Crooks, G, Gutter, Z, Iaccarino, G, Manuel de Keenoy, E, Moda, G, Rodriguez-Mañas, L, Vontetsianos, T, Abreu, C, Alonso, J, Alonso-Bouzon, C, Ankri, J, Arredondo, M T, Avolio, F, Bedbrook, A, Białoszewski, A Z, Blain, H, Bourret, R, Cabrera-Umpierrez, M F, Catala, A, O'Caoimh, R, Cesari, M, Chavannes, N H, Correia-da-Sousa, J, Dedeu, T, Ferrando, M, Ferri, M, Fokkens, W J, Garcia-Lizana, F, Guérin, O, Hellings, P W, Haahtela, T, Illario, M, Inzerilli, M C, Lodrup Carlsen, K C, Kardas, P, Keil, T, Maggio, M, Mendez-Zorrilla, A, Menditto, E, Mercier, J, Michel, J P, Murray, R, Nogues, M, O'Byrne-Maguire, I, Pappa, D, Parent, A S, Pastorino, M, Robalo-Cordeiro, C, Samolinski, B, Siciliano, P, Teixeira, A M, Tsartara, S I, Valiulis, A, Vandenplas, O, Vasankari, T, Vellas, B, Vollenbroek-Hutten, M, Wickman, M, Yorgancioglu, A, Zuberbier, T, Barbagallo, M, Canonica, G W, Klimek, L, Maggi, S, Aberer, W, Akdis, C, Adcock, I M, Agache, I, Albera, C, Alonso-Trujillo, F, Angel Guarcia, M, Annesi-Maesano, I, Apostolo, J, Arshad, S H, Attalin, V, Avignon, A, Bachert, C, Baroni, I, Bel, E, Benson, M, Bescos, C, Blasi, F, Barbara, C, Bergmann, K C, Bernard, P L, Bonini, S, Bousquet, P J, Branchini, B, Brightling, C E, Bruguière, V, Bunu, C, Bush, A, Caimmi, D P, Calderon, M A, Canovas, G, Cardona, V, Carlsen, K H, Cesario, A, Chkhartishvili, E, Chiron, R, Chivato, T, Chung, K F, d'Angelantonio, M, De Carlo, G, Cholley, D, Chorin, F, Combe, B, Compas, B, Costa, D J, Costa, E, Coste, O, Coupet, A-L, Crepaldi, G, Custovic, A, Dahl, R, Dahlen, S E, Demoly, P, Devillier, P, Didier, A, Dinh-Xuan, A T, Djukanovic, R, Dokic, D, Du Toit, G, Dubakiene, R, Dupeyron, A, Emuzyte, R, Fiocchi, A, Wagner, A, Fletcher, M, Fonseca, J, Fougère, B, Gamkrelidze, A, Garces, G, Garcia-Aymeric, J, Garcia-Zapirain, B, Gemicioğlu, B, Gouder, C, Hellquist-Dahl, B, Hermosilla-Gimeno, I, Héve, D, Holland, C, Humbert, M, Hyland, M, Johnston, S L, Just, J, Jutel, M, Kaidashev, I P, Khaitov, M, Kalayci, O, Kalyoncu, A F, Keijser, W, Kerstjens, H, Knezović, J, Kowalski, M, Koppelman, G H, Kotska, T, Kovac, M, Kull, I, Kuna, P, Kvedariene, V, Lepore, V, MacNee, W, Magnan, A, Majer, I, Manning, P, Marcucci, M, Marti, T, Masoli, M, Melen, E, Miculinic, N, Mihaltan, F, Milenkovic, B, Millot-Keurinck, J, Mlinarić, H, Momas, I, Montefort, S, Morais-Almeida, M, Moreno-Casbas, T, Mösges, R, Mullol, J, Nadif, R, Nalin, M, Navarro-Pardo, E, Nekam, K, Ninot, G, Paccard, D, Pais, S, Palummeri, E, Panzner, P, Papadopoulos, N K, Papanikolaou, C, Passalacqua, G, Pastor, E, Perrot, M, Plavec, D, Popov, T A, Postma, D S, Price, D, Raffort, N, Reuzeau, J C, Robine, J M, Rodenas, F, Robusto, F, Roche, N, Romano, A, Romano, V, Rosado-Pinto, J, Roubille, F, Ruiz, F, Ryan, D, Salcedo, T, Schmid-Grendelmeier, P, Schulz, H, Schunemann, H J, Serrano, E, Sheikh, A, Shields, M, Siafakas, N, Scichilone, N, Skrindo, I, Smit, H A, Sourdet, S, Sousa-Costa, E, Spranger, O, Sooronbaev, T, Sruk, V, Sterk, P J, Todo-Bom, A, Touchon, J, Tramontano, D, Triggiani, M, Valero, A L, Valovirta, E, van Ganse, E, van Hage, M, van den Berge, M, Ventura, M T, Vergara, I, Vezzani, G, Vidal, D, Viegi, G, Wagemann, M, Whalley, B, Wilson, N, Yiallouros, P K, Žagar, M, Zaidi, A, Zidarn, M, Hoogerwerf, E J, Usero, J, Zuffada, R, Senn, A, and de Oliveira-Alves, B
Published: 2017

48. FOXM1 expression is significantly associated with chemotherapy resistance and adverse prognosis in non-serous epithelial ovarian cancer patients

Author: Tassi, Ra, Todeschini, P, Siegel, Er, Calza, S, Cappella, P, Ardighieri, L, Cadei, M, Bugatti, M, Romani, C, Bandiera, E, Zanotti, L, Tassone, L, Guarino, D, Santonocito, C, Capoluongo, Ed, Beltrame, L, Erba, E, Marchini, S, D'Incalci, M, Donzelli, C, Santin, Ad, Pecorelli, S, Sartori, E, Bignotti, E, Odicino, F, Ravaggi, A., Santonocito, C (ORCID:0000-0003-3624-1386), Capoluongo, ED (ORCID:0000-0001-9872-0572), Tassi, Ra, Todeschini, P, Siegel, Er, Calza, S, Cappella, P, Ardighieri, L, Cadei, M, Bugatti, M, Romani, C, Bandiera, E, Zanotti, L, Tassone, L, Guarino, D, Santonocito, C, Capoluongo, Ed, Beltrame, L, Erba, E, Marchini, S, D'Incalci, M, Donzelli, C, Santin, Ad, Pecorelli, S, Sartori, E, Bignotti, E, Odicino, F, Ravaggi, A., Santonocito, C (ORCID:0000-0003-3624-1386), and Capoluongo, ED (ORCID:0000-0001-9872-0572)
Abstract: Background: Epithelial ovarian cancer (EOC) is a spectrum of different diseases, which makes their treatment a challenge. Forkhead box M1 (FOXM1) is an oncogene aberrantly expressed in many solid cancers including serous EOC, but its role in non-serous EOCs remains undefined. We examined FOXM1 expression and its correlation to prognosis across the three major EOC subtypes, and its role in tumorigenesis and chemo-resistance in vitro. Methods: Gene signatures were generated by microarray for 14 clear-cell and 26 endometrioid EOCs, and 15 normal endometrium snap-frozen biopsies. Validation of FOXM1 expression was performed by RT-qPCR and immunohistochemistry in the same samples and additionally in 50 high-grade serous EOCs and in their most adequate normal controls (10 luminal fallopian tube and 20 ovarian surface epithelial brushings). Correlations of FOXM1 expression to clinic-pathological parameters and patients' prognosis were evaluated by Kaplan-Meier and Cox proportional-hazards analyses. OVCAR-3 and two novel deeply characterized EOC cell lines (EOC-CC1 and OSPC2, with clear-cell and serous subtype, respectively) were employed for in vitro studies. Effects of FOXM1 inhibition by transient siRNA transfection were evaluated on cell-proliferation, cell-cycle, colony formation, invasion, and response to conventional first-and second-line anticancer agents, and to the PARP-inhibitor olaparib. Gene signatures of FOXM1-silenced cell lines were generated by microarray and confirmed by RT-qPCR. Results: A significant FOXM1 mRNA up-regulation was found in EOCs compared to normal controls. FOXM1 protein overexpression significantly correlated to serous histology (p = 0.001) and advanced FIGO stage (p = 0.004). Multivariate analyses confirmed FOXM1 protein overexpression as an independent indicator of worse disease specific survival in non-serous EOCs, and of shorter time to progression in platinum-resistant cases. FOXM1 downregulation in EOC cell lines inhibited cell growt
Published: 2017

49. Treatment of skeletal impairment in patients with endogenous hypercortisolism: when and how?

Author: Scillitani A, Mazziotti G, Di Somma C, Moretti S, Stigliano A, Pivonello R, Giustina A, Colao A, Albiger N, Ambrogio A, Arnaldi G, Arvat E, Baldelli R, Berardelli R, Boscaro M, Cannavò S, Cavagnini F, Corsello SM, Cozzolino A, De Bartolomeis A, De Leo M, Di Minno G, Esposito K, Fabbrocini G, Ferone D, Foresta C, Galderisi M, Giordano C, Grimaldi F, Isidori AM, Jannini E, Lombardo F, Manetti L, Mannelli M, Mantero F, Marone G, Nazzari E, Paragliola RM, Pasquali R, Pecorelli S, Pecori Giraldi F, Pivonello C, Reimondo G, Scaroni C, Simeoli C, Toscano V, Trementino L, Vitale G, Zatelli M.C.)., ESPOSITO, Katherine, GIUGLIANO, Dario, Scillitani, A, Mazziotti, G, Di Somma, C, Moretti, S, Stigliano, A, Pivonello, R, Giustina, A, Esposito, Katherine, Colao, A, Albiger, N, Ambrogio, A, Arnaldi, G, Arvat, E, Baldelli, R, Berardelli, R, Boscaro, M, Cannavò, S, Cavagnini, F, Corsello, Sm, Cozzolino, A, De Bartolomeis, A, De Leo, M, Di Minno, G, Esposito, K, Fabbrocini, G, Ferone, D, Foresta, C, Galderisi, M, Giordano, C, Giugliano, Dario, Grimaldi, F, Isidori, Am, Jannini, E, Lombardo, F, Manetti, L, Mannelli, M, Mantero, F, Marone, G, Nazzari, E, Paragliola, Rm, Pasquali, R, Pecorelli, S, Pecori Giraldi, F, Pivonello, C, Reimondo, G, Scaroni, C, Simeoli, C, Toscano, V, Trementino, L, Vitale, G, and Zatelli, M. C. ).
Published: 2014

50. Erratum to: Building bridges for innovation in ageing: Synergies between action groups of the EIP on AHA

Author: Bousquet, J. Bewick, M. Cano, A. Eklund, P. Fico, G. Goswami, N. Guldemond, N.A. Henderson, D. Hinkema, M.J. Liotta, G. Mair, A. Molloy, W. Monaco, A. Monsonis-Paya, I. Nizinska, A. Papadopoulos, H. Pavlickova, A. Pecorelli, S. Prados-Torres, A. Roller-Wirnsberger, R.E. Somekh, D. Vera-Muñoz, C. Visser, F. Farrell, J. Malva, J. Andersen Ranberg, K. Camuzat, T. Carriazo, A.M. Crooks, G. Gutter, Z. Iaccarino, G. de Keenoy, E.M. Moda, G. Rodriguez-Mañas, L. Vontetsianos, T. Abreu, C. Alonso, J. Alonso-Bouzon, C. Ankri, J. Arredondo, M.T. Avolio, F. Bedbrook, A. Białoszewski, A.Z. Blain, H. Bourret, R. Cabrera-Umpierrez, M.F. Catala, A. O’Caoimh, R. Cesari, M. Chavannes, N.H. Correia-Da-Sousa, J. Dedeu, T. Ferrando, M. Ferri, M. Fokkens, W.J. Garcia-Lizana, F. Guérin, O. Hellings, P.W. Haahtela, T. Illario, M. Inzerilli, M.C. Lodrup Carlsen, K.C. Kardas, P. Keil, T. Maggio, M. Mendez-Zorrilla, A. Menditto, E. Mercier, J. Michel, J.P. Murray, R. Nogues, M. O’Byrne-Maguire, I. Pappa, D. Parent, A.S. Pastorino, M. Robalo-Cordeiro, C. Samolinski, B. Siciliano, P. Teixeira, A.M. Tsartara, S.I. Valiulis, A. Vandenplas, O. Vasankari, T. Vellas, B. Vollenbroek-Hutten, M. Wickman, M. Yorgancioglu, A. Zuberbier, T. Barbagallo, M. Canonica, G.W. Klimek, L. Maggi, S. Aberer, W. Akdis, C. Adcock, I.M. Agache, I. Albera, C. Alonso-Trujillo, F. Angel Guarcia, M. Annesi-Maesano, I. Apostolo, J. Arshad, S.H. Attalin, V. Avignon, A. Bachert, C. Baroni, I. Bel, E. Benson, M. Bescos, C. Blasi, F. Barbara, C. Bergmann, K.C. Bernard, P.L. Bonini, S. Bousquet, P.J. Branchini, B. Brightling, C.E. Bruguière, V. Bunu, C. Bush, A. Caimmi, D.P. Calderon, M.A. Canovas, G. Cardona, V. Carlsen, K.H. Cesario, A. Chkhartishvili, E. Chiron, R. Chivato, T. Chung, K.F. D’Angelantonio, M. de Carlo, G. Cholley, D. Chorin, F. Combe, B. Compas, B. Costa, D.J. Costa, E. Coste, O. Coupet, A.-L. Crepaldi, G. Custovic, A. Dahl, R. Dahlen, S.E. Demoly, P. Devillier, P. Didier, A. Dinh-Xuan, A.T. Djukanovic, R. Dokic, D. du Toit, G. Dubakiene, R. Dupeyron, A. Emuzyte, R. Fiocchi, A. Wagner, A. Fletcher, M. Fonseca, J. Fougère, B. Gamkrelidze, A. Garces, G. Garcia-Aymeric, J. Garcia-Zapirain, B. Gemicioğlu, B. Gouder, C. Hellquist-Dahl, B. Hermosilla-Gimeno, I. Héve, D. Holland, C. Humbert, M. Hyland, M. Johnston, S.L. Just, J. Jutel, M. Kaidashev, I.P. Khaitov, M. Kalayci, O. Kalyoncu, A.F. Keijser, W. Kerstjens, H. Knezović, J. Kowalski, M. Koppelman, G.H. Kotska, T. Kovac, M. Kull, I. Kuna, P. Kvedariene, V. Lepore, V. Macnee, W. Maggio, M. Magnan, A. Majer, I. Manning, P. Marcucci, M. Marti, T. Masoli, M. Melen, E. Miculinic, N. Mihaltan, F. Milenkovic, B. Millot-Keurinck, J. Mlinarić, H. Momas, I. Montefort, S. Morais-Almeida, M. Moreno-Casbas, T. Mösges, R. Mullol, J. Nadif, R. Nalin, M. Navarro-Pardo, E. Nekam, K. Ninot, G. Paccard, D. Pais, S. Palummeri, E. Panzner, P. Papadopoulos, N.K. Papanikolaou, C. Passalacqua, G. Pastor, E. Perrot, M. Plavec, D. Popov, T.A. Postma, D.S. Price, D. Raffort, N. Reuzeau, J.C. Robine, J.M. Rodenas, F. Robusto, F. Roche, N. Romano, A. Romano, V. Rosado-Pinto, J. Roubille, F. Ruiz, F. Ryan, D. Salcedo, T. Schmid-Grendelmeier, P. Schulz, H. Schunemann, H.J. Serrano, E. Sheikh, A. Shields, M. Siafakas, N. Scichilone, N. Siciliano, P. Skrindo, I. Smit, H.A. Sourdet, S. Sousa-Costa, E. Spranger, O. Sooronbaev, T. Sruk, V. Sterk, P.J. Todo-Bom, A. Touchon, J. Tramontano, D. Triggiani, M. Tsartara, S.I. Valero, A.L. Valovirta, E. van Ganse, E. van Hage, M. van Den Berge, M. Vandenplas, O. Ventura, M.T. Vergara, I. Vezzani, G. Vidal, D. Viegi, G. Wagemann, M. Whalley, B. Wickman, M. Wilson, N. Yiallouros, P.K. Žagar, M. Zaidi, A. Zidarn, M. Hoogerwerf, E.J. Usero, J. Zuffada, R. Senn, A. de Oliveira-Alves, B.
Abstract: The authors would like to change and use the correct name of M. Khaitov which is M. Kaitov on this manuscript. The authors have incorrectly used her other name during the finalization of this research. With this, the authors hereby publish the correct author names as presented above. © 2016 Serdi and Springer-Verlag France
Published: 2016

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