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2. Scientific considerations for global drug development

3. Contributors

10. Opportunities for Integration of Pharmacokinetics, Pharmacodynamics and Toxicokinetics in Rational Drug Development

19. Population pharmacokinetic analysis and simulation of the time-concentration profile of etanercept in pediatric patients with juvenile rheumatoid arthritis

21. Contributors

27. Contributors

30. Opportunities for Integration of Pharmacokinetics, Pharmacodynamics, and Toxicokinetics in Rational Drug Development

39. Farewell to our Wonderful Friend and Colleague, J. Richard (Dick) Crout (1929–2020).

47. Probability of Success: A Crucial Concept to Inform Decision Making in Pharmaceutical Research and Development.

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