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23 results on '"Pechauer, Shannon"'

1. A prospective, blinded study of a PF4-dependent assay for HIT diagnosis

Author

Samuelson Bannow, Bethany, Warad, Deepti M., Jones, Curtis G., Pechauer, Shannon M., Curtis, Brian R., Bougie, Daniel W., Sharma, Ruchika, Grill, Diane E., Redman, Mary W., Khalighi, Parisa R., Leger, Rachel R., Pruthi, Rajiv K., Chen, Dong, Sabath, Daniel E., Aster, Richard H., Garcia, David A., and Padmanabhan, Anand

Published
2021
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5. ELISA-Negative Platelet-Activating Anti-PF4 Antibodies Can Cause HIT and Monoclonal Gammopathy of Thrombotic Significance (MGTS)

Author

Kanack, Adam, Leung, Nelson, Splinter, Noah, Mauch, Emily, Reyes Gil, Morayma, Tefera, Leben, Jasra, Sakshi, Goodwin, Andrew, Audil, Hadiyah, Ashrani, Aneel, Robinson, Nathaniel L., Casanegra, Ana I., Jones, Curtis, Pechauer, Shannon, Yttre, Erin, Kohlhagen, Mindy, Leger, Rachel, Murray, David L, Chen, Dong, Pruthi, Rajiv K., and Pabmanabhan, Anand

Published
2023
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9. Enzymatic Synthesis of Chondroitin Sulfate E to Attenuate Bacteria Lipopolysaccharide-Induced Organ Damage

Author

Li, Jine, primary, Sparkenbaugh, Erica M., additional, Su, Guowei, additional, Zhang, Fuming, additional, Xu, Yongmei, additional, Xia, Ke, additional, He, Pen, additional, Baytas, Sultan, additional, Pechauer, Shannon, additional, Padmanabhan, Anand, additional, Linhardt, Robert J., additional, Pawlinski, Rafal, additional, and Liu, Jian, additional

Published
2020
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12. The Platelet Factor-4 (PF4)-Dependent p-Selectin Expression Assay (PEA) Is Highly Accurate for the Detection of Pathogenic HIT Antibodies: Results of a 440-Sample Prospective Blinded Study

Author

Warad, Deepti M., primary, Samuelson Bannow, Bethany T, additional, Jones, Curtis, additional, Pechauer, Shannon, additional, Curtis, Brian R., additional, Bougie, Daniel W., additional, Khalighi, Parisa R, additional, Grill, Diane E., additional, Leger, Rachel, additional, Sharma, Ruchika, additional, Chen, Dong, additional, Aster, Richard H., additional, Garcia, David A., additional, and Padmanabhan, Anand, additional

Published
2018
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13. A Novel PF4-Dependent P-Selectin Expression Assay (PEA) Facilitates Early Detection of Pathogenic HIT Antibodies: Implications for Diagnosis and Treatment of HIT

Author

Padmanabhan, Anand, primary, Jones, Curtis G, additional, Pechauer, Shannon M, additional, Curtis, Brian R, additional, Bougie, Daniel W., additional, Sullivan, Mia J, additional, Irani, Mehraboon S., additional, Dhakal, Binod, additional, Baumann Kreuziger, Lisa M., additional, Pierce, Brenda M., additional, and Aster, Richard H., additional

Published
2016
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14. Intravenous Immunoglobulin (IVIg) Is a Highly Effective Treatment for HIT: Critical Role of the IgG Fc Domain in Inhibiting HIT Antibody-Mediated Platelet Activation

Author

Padmanabhan, Anand, primary, Jones, Curtis G, additional, Pechauer, Shannon M, additional, Bryant, Barbara J., additional, Alperin, Jack B., additional, Irani, Mehraboon S., additional, Dhakal, Binod, additional, Curtis, Brian R, additional, Bougie, Daniel W., additional, Sullivan, Mia J, additional, Wen, Renren, additional, Wang, Demin, additional, and Aster, Richard H., additional

Published
2016
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15. LOW FREQUENCY HUMAN PLATELET ANTIGENS (HPA) AS TRIGGERS FOR NEONATAL ALLOIMMUNE THROMBOCYTOPENIA (NAIT)

Author

Peterson, Julie A., Gitter, Maria, Bougie, Daniel W., Pechauer, Shannon, Hopp, Kathleen A., Pietz, Brad, Szabo, Aniko, Curtis, Brian R., McFarland, Janice, and Aster, Richard H.

Subjects
Male, Thrombocytopenia, Neonatal Alloimmune, Humans, Antigens, Human Platelet, Female, Polymorphism, Single Nucleotide, Article, Alleles, High-Throughput Screening Assays
Abstract

Twenty-four low-frequency human platelet antigens (LFHPAs) have been implicated as immunogens in neonatal alloimmune thrombocytopenia (NAIT). We performed studies to define more fully how often these antigens trigger maternal immunization leading to NAIT.In a Phase 1 study, fathers of selected NAIT cases not resolved by serologic testing but thought to have a high likelihood of NAIT on clinical and serologic grounds were typed for LFHPAs by DNA sequencing. In a Phase 2 study, high-throughput methods were used to type fathers of 1067 consecutive unresolved NAIT cases for LFHPAs. Mothers of 1338 unresolved cases were also typed to assess the prevalence of LFHPAs in a population racially/ethnically similar to the fathers.In Phase 1, LFHPAs were identified in 16 of 244 fathers (6.55%). In Phase 2, LFPAs were found in only 28 of 1067 fathers (2.62%). LFHPAs were identified in 27 of 1338 maternal samples (2.01%). HPA-9bw was by far the most common LFHPA identified in the populations studied and was the only LFHPA that was significantly more common in fathers than in mothers of affected infants (p = 0.02).Maternal immunization against recognized LFHPAs accounts for only a small fraction of the cases of apparent NAIT not resolved by standard serologic testing. Typing of the fathers of such cases for LFHPAs is likely to be rewarding only when a maternal antibody specific for a paternal platelet glycoprotein is demonstrated and/or there is compelling clinical evidence for NAIT.

Published
2013

16. TO THE EDITOR: Normal plasma IgG inhibits HIT antibody--mediated platelet activation: implications for therapeutic plasma exchange.

Author

Jones, Curtis G., Pechauer, Shannon M., Curtis, Brian R., Bougie, Daniel W., Aster, Richard H., and Padmanabhan, Anand

Subjects
*IMMUNOGLOBULIN G, *HEPARIN, *THROMBOCYTOPENIA, *BLOOD platelets, *PLASMA exchange (Therapeutics)
Abstract

The article discusses implications for therapeutic plasma immunoglobulin G (IgG) exchange, inhibiting heparin-induced thrombocytopenia antibody. It mentions PF4-dependent P-selectin expression assay (PEA) using platelets pretreated with low-dose PF4. It also mentions effects of serial plasma exchange by reducing the HIT antibody to final concentrations.

Published
2018
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17. New platelet glycoprotein polymorphisms causing maternal immunization and neonatal alloimmune thrombocytopenia

Author

Peterson, Julie A., Pechauer, Shannon M., Gitter, Maria L., Kanack, Adam, Curtis, Brian R., Reese, Jeff, Kamath, Vasudeva M., McFarland, Janice G, and Aster, Richard H.

Subjects
Male, Thrombocytopenia, Neonatal Alloimmune, Polymorphism, Genetic, Pregnancy, Mutation, Infant, Newborn, Humans, Antigens, Human Platelet, Female, Platelet Membrane Glycoproteins, Article
Abstract

Maternal immunization against low-frequency, platelet (PLT)-specific antigens is being recognized with increasing frequency as a cause of neonatal alloimmune thrombocytopenia (NAIT).Serologic and molecular studies were performed on PLTs and DNA from two families in which an infant was born with severe thrombocytopenia not attributable to maternal immunization against known PLT-specific alloantigens.Antibodies reactive only with paternal PLTs were identified in each mother using flow cytometry and solid-phase assays. Unique mutations encoding amino acid substitutions K164T in glycoprotein (GP)IIb (Case 1) and R622W in GPIIIa (Case 2) were identified in paternal DNA and in DNA from the affected infants. Each maternal antibody recognized recombinant GPIIb/IIIa mutated to contain the polymorphisms identified in the corresponding father. None of 100 unselected normal subjects possessed these paternal mutations.Severe NAIT observed in the affected infants was caused by maternal immunization against previously unrecognized, low-frequency antigens created by amino acid substitutions in GPIIb/IIIa (α(IIb) /β(3) integrin). A search should be conducted for novel paternal antigens in cases of apparent NAIT not explained on the basis of maternal-fetal incompatibility for known human PLT antigens.

Published
2011

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