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1. A Phase I Study of the Antimetabolite (E)-2'-Fluoromethylene-2' - Deoxycytidine (MDL 101,731) Administered as a Twice-Weekly Infusion.

Author

Burtness, B., Belker, M., Stoltz, M., Peccerillo, K.M., Lamb, L.A., Chmael, S.E., McKeon, A., Clark, M.B., Winship, J., Marsh, J.C., Pizzorno, G., and DeVita Jr, V.T.

Subjects
CANCER chemotherapy, ANTIMETABOLITES, DRUG therapy
Abstract

Highlights the results of a phase I trial of (E)-2-fluoromethylene-2-deoxycytidine infusion in humans with advanced cancer. Maximum tolerated dose and the dose-limiting toxicities of the drug when administered on a twice-weekly schedule; Ribonucleotide reductase; Epithelial malignancies.

Published
2000

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