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11 results on '"Pearson, Gill"'

4. Raman Spectroscopic Analysis of Fingernail Clippings Can Help Differentiate between Postmenopausal Women who Have and Have Not Suffered a Fracture

Author

Beattie, Rene, Towler, Mark, Cummins, Niamh, Bransbury, Clare, Ralston, Stuart, Eastell, Richard, Pearson, Gill, Stone, Michael D., Bansal, Aruna, and O'Driscoll, Olive

Subjects
Pathology, medicine.medical_specialty, DEXA, lcsh:Diseases of the musculoskeletal system, Fracture risk, Osteoporosis, Calibration set, QFracture, Early detection, 02 engineering and technology, bone, 01 natural sciences, symbols.namesake, Rheumatology, medicine, Immunology and Allergy, Bone, Original Research, Postmenopausal women, Nail clippings, business.industry, 010401 analytical chemistry, Area under the curve, 021001 nanoscience & nanotechnology, medicine.disease, osteoporosis, 0104 chemical sciences, Raman spectroscopy, Fracture (geology), symbols, Radiology, lcsh:RC925-935, 0210 nano-technology, business
Abstract

Raman spectroscopy was applied to nail clippings from 633 postmenopausal British and Irish women, from six clinical sites, of whom 42% had experienced a fragility fracture. The objective was to build a prediction algorithm for fracture using data from four sites (known as the calibration set) and test its performance using data from the other two sites (known as the validation set). Results from the validation set showed that a novel algorithm, combining spectroscopy data with clinical data, provided area under the curve (AUC) of 74% compared to an AUC of 60% from a reduced QFracture score (a clinically accepted risk calculator) and 61% from the dual-energy X-ray absorptiometry T-score, which is in current use for the diagnosis of osteoporosis. Raman spectroscopy should be investigated further as a noninvasive tool for the early detection of enhanced risk of fragility fracture.

Published
2016

5. Patients’ preferences for anti-osteoporosis drug treatment: a cross-European discrete choice experiment

Author

Hiligsmann, Mickaël, primary, Dellaert, Benedict G., additional, Dirksen, Carmen D., additional, Watson, Verity, additional, Bours, Sandrine, additional, Goemaere, Stefan, additional, Reginster, Jean-Yves, additional, Roux, Christian, additional, McGowan, Bernie, additional, Silke, Carmel, additional, Whelan, Bryan, additional, Diez-Perez, Adolfo, additional, Torres, Elisa, additional, Papadakis, Georgios, additional, Rizzoli, Rene, additional, Cooper, Cyrus, additional, Pearson, Gill, additional, and Boonen, Annelies, additional

Published
2017
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11. Raman spectroscopic analysis of fingernail clippings can help differentiate between postmenopausal women who have and have not suffered a fracture

Author

Crescent Diagnostics Limited, Beattie, James R., Cummins, Niamh M., Caraher, Clare, O'Driscoll, Olive M., Bansal, Aruna T., Eastell, Richard, Ralston, Stuart H., Stone, Michael D., Pearson, Gill, Towler, M.R., Crescent Diagnostics Limited, Beattie, James R., Cummins, Niamh M., Caraher, Clare, O'Driscoll, Olive M., Bansal, Aruna T., Eastell, Richard, Ralston, Stuart H., Stone, Michael D., Pearson, Gill, and Towler, M.R.

Abstract

peer-reviewed, Raman spectroscopy was applied to nail clippings from 633 postmenopausal British and Irish women, from six clinical sites, of whom 42% had experienced a fragility fracture. The objective was to build a prediction algorithm for fracture using data from four sites (known as the calibration set) and test its performance using data from the other two sites (known as the validation set). Results from the validation set showed that a novel algorithm, combining spectroscopy data with clinical data, provided area under the curve (AUC) of 74% compared to an AUC of 60% from a reduced QFracture score (a clinically accepted risk calculator) and 61% from the dual-energy X-ray absorptiometry T-score, which is in current use for the diagnosis of osteoporosis. Raman spectroscopy should be investigated further as a noninvasive tool for the early detection of enhanced risk of fragility fracture.

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