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5,460 results on '"Pearson, A. M."'

1. Unified equations of state for cold nonaccreting neutron stars with Brussels-Montreal functionals. V. Improved parametrization of the nucleon density distributions

Author

Shchechilin, N. N., Chamel, N., Pearson, J. M., Chugunov, A. I., and Potekhin, A. Y.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Nuclear Theory
Abstract

We previously studied the inner crust and the pasta mantle of a neutron star within the 4th-order extended Thomas-Fermi (ETF) approach with consistent proton shell corrections added perturbatively via the Strutinsky integral (SI) theorem together with the contribution due to pairing. To speed up the computations and avoid numerical problems, we adopted parametrized nucleon density distributions. However, the errors incurred by the choice of the parametrization are expected to become more significant as the mean baryon number density is increased, especially in the pasta mantle where the differences in the energy per nucleon of the different phases are very small, typically a few keV. To improve the description of these exotic structures, we discuss the important features that a nuclear profile should fulfill and introduce two new parametrizations. Performing calculations using the BSk24 functional, we find that these parametrizations lead to lower ETF energy solutions for all pasta phases than the parametrization we adopted before and more accurately reproduce the exact equilibrium nucleon density distributions obtained from unconstrained variational calculations. Within the ETFSI method, all parametrizations predict the same composition in the region with quasi-spherical clusters. However, the two new parametrizations lead to a different mantle structure at mean baryon densities above about 0.07 fm^-3, at which point lasagna is energetically favored. Interestingly, spherical clusters reappear in the pasta region. The inverted pasta phases such as bucatini and Swiss cheese are still found in the densest region above the core in all cases., Comment: 12 pages, 9 figures, published in Phys. Rev. C

Published
2024
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5. Unified equations of state for cold non-accreting neutron stars with Brussels-Montreal functionals. IV. Role of the symmetry energy in pasta phases

Author

Shchechilin, N. N., Chamel, N., and Pearson, J. M.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Nuclear Theory
Abstract

Our previous investigation of neutron-star crusts, based on the functional BSk24, led to a substantial reduction of the pasta mantle when Strutinsky integral and pairing corrections were added on top of the fourth-order extended Thomas-Fermi method (ETF). Here, our earlier calculations are widened to a larger set of functionals within the same family, and we find that the microscopic corrections weaken significantly the influence of the symmetry energy. In particular, the correlation observed at the pure ETF level between the density for the onset of pasta formation and the symmetry energy vanishes, not only for the $L$ coefficient but also for the symmetry-energy values at the relevant densities. Moreover, the inclusion of microscopic corrections results in a much lower abundance of pasta for all functionals., Comment: 11 pages, 4 figures

Published
2023
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10. The Association between Retiree Migration and Retirement Satisfaction

Author

Pearson, Blain M. and Kalenkoski, Charlene M.

Abstract

The purpose of this study is to examine migration during retirement and its association with retirement satisfaction. Utilizing longitudinal data collected from the Health and Retirement Study, this study estimates a fixed-effects logit model to examine how changing U.S. Census divisions during retirement is related to retirement satisfaction. The findings suggest that a change in residential location during retirement is associated with an increase in retirement satisfaction. In planning for retirement, individuals should examine what will provide them with the highest level of satisfaction during their retirement and whether their current location can facilitate an enjoyable retirement. Financial planners and counselors should also consider, as a part of their systemic retirement planning process, increasing the attention that is given to the residential location in which their clients will reside during retirement.

Published
2022

12. Accreting neutron stars from the nuclear energy-density functional theory. II. Equation of state and global properties

Author

Fantina, A. F., Zdunik, J. L., Chamel, N., Pearson, J. M., Suleiman, L., and Goriely, S.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Nuclear Theory
Abstract

The accretion of matter onto the surface of a neutron star in a low-mass X-ray binary triggers X-ray bursts, whose ashes are buried and further processed thus altering the composition and the properties of the stellar crust. In this second paper of a series, the impact of accretion on the equation of state and on the global properties of neutron stars is studied in the framework of the nuclear energy-density functional theory. Considering ashes made of $^{56}$Fe, we calculated the equations of state using the same Brussels-Montreal nuclear energy-density functionals BSk19, BSk20, and BSk21, as those already employed for determining the crustal heating in our previous study for the same ashes. All regions of accreting neutron stars were treated in a unified and thermodynamically consistent way. With these equations of state, we determined the mass, radius, moment of inertia, and tidal deformability of accreted neutron stars and compared with catalyzed neutron stars for which unified equations of state based on the same functionals are available. The equation of state of accreted neutron stars is found to be significantly stiffer than that of catalyzed matter, with an adiabatic index $\Gamma \approx 4/3$ throughout the crust. For this reason, accreting neutron stars have larger radii. However, their crustal moment of inertia and their tidal deformability are hardly changed provided density discontinuities at the interface between adjacent crustal layers are properly taken into account. The enhancement of the stiffness of the equation of state of accreting neutron stars is mainly a consequence of nuclear shell effects, thus confirming the importance of a quantum treatment as stressed in our first study. With our previous calculations of crustal heating using the same functionals, we have thus obtained consistent microscopic inputs for simulations of accreting neutron stars., Comment: 10 pages, 7 figures. The tables of the equations of state are available at the CDS

Published
2022
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13. Enabling conservation theories of change

Author

Buelow, Christina A., Connolly, Rod M., Dunic, Jillian C., Griffiths, Laura, Holgate, Briana, Lee, Shing Yip, Mackey, Brendan G., Maxwell, Paul S., Pearson, Ryan M., Rajkaran, Anusha, Sievers, Michael, Sousa, Ana I., Tulloch, Vivitskaia J. D., Turschwell, Mischa P., Villarreal-Rosas, Jaramar, and Brown, Christopher J.

Published
2024
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14. Maternal Postnatal Depressive Symptoms and Offspring Emotional and Behavioral Development at Age 7 Years in a U.K. Birth Cohort: The Role of Paternal Involvement

Author

Culpin, Iryna, Hammerton, Gemma, Stein, Alan, Bornstein, Marc H., Tiemeier, Henning, Cadman, Tim, Fredriksen, Eivor, Evans, Jonathan, Miller, Tina, Dermott, Esther, Heron, Jon, Sallis, Hannah M., and Pearson, Rebecca M.

Abstract

There is considerable variability in developmental outcomes of children whose mothers experience depression. Few longitudinal studies have examined contributions of paternal involvement in the association between maternal postnatal depression (PND) and offspring development. We examined pathways from maternal PND at 8 weeks (Edinburgh Postnatal Depression Scale; total score) to offspring emotional and behavioral development at 7 years (Strengths and Difficulties Questionnaire; total score) through behavioral, affective, and cognitive dimensions of paternal involvement in a U.K.-based birth cohort (Avon Longitudinal Study of Parents and Children; n = 3,434). Analyses were adjusted for baseline confounders and paternal PND (Edinburgh Postnatal Depression Scale; total score) as an intermediate confounder. Maternal PND was strongly associated with offspring development, but this association was not mediated by the combination of all indirect pathways through various dimensions of paternal involvement. Only father--child conflict emerged as a risk factor for adverse offspring development and as a mediator in the association between maternal PND and offspring development (albeit the effect size was small). If found causal, interventions that reduce father-child conflict may reduce the risk of adverse development in offspring of mothers with PND.

Published
2023
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15. Static Electricity: Institutional and Ideational Barriers to China’s Market Reforms

Author

Davidson, Michael R and Pearson, Margaret M

Subjects
Affordable and Clean Energy, Climate Action, Market reform, China, State capitalism, Institutions, Electric power, Studies in Human Society, Political Science & Public Administration
Abstract

AbstractChina’s “economic juggernaut” is often noted to have arisen from successful market reforms carried out in the context of high state capacity. In contrast, we demonstrate that crucial reforms to replace central planning with markets have stalled as a result of major barriers of two types: institutional and ideational. Focusing on the electricity sector, we find that market reforms pushed by China’s central government are hindered by deep inefficiencies that arise from the legacy plan and “plan-derived” institutions of subnational governments and grid companies, against which the central state has been largely ineffective. We also uncover fascinating ideational differences of the nature and purpose of “markets” that show how they often are envisioned more as a way to extend the planner’s “toolbox,” or to offer “salvation” for ailing incumbent firms, rather than to induce efficiency. Our empirical focus on three prominent types of “market-oriented” experiments in the electric power sector demonstrate clear limits to state capacity, limits that emanate from state actors rather than merely industry, despite high-priority central government goals of increasing efficiency, integrating renewable energy, and reducing emissions from the electricity sector.

Published
2022

27. Online neural connectivity estimation with ensemble stimulation

Author

Draelos, Anne, Naumann, Eva A., and Pearson, John M.

Subjects
Computer Science - Machine Learning, Quantitative Biology - Neurons and Cognition, Statistics - Machine Learning
Abstract

One of the primary goals of systems neuroscience is to relate the structure of neural circuits to their function, yet patterns of connectivity are difficult to establish when recording from large populations in behaving organisms. Many previous approaches have attempted to estimate functional connectivity between neurons using statistical modeling of observational data, but these approaches rely heavily on parametric assumptions and are purely correlational. Recently, however, holographic photostimulation techniques have made it possible to precisely target selected ensembles of neurons, offering the possibility of establishing direct causal links. Here, we propose a method based on noisy group testing that drastically increases the efficiency of this process in sparse networks. By stimulating small ensembles of neurons, we show that it is possible to recover binarized network connectivity with a number of tests that grows only logarithmically with population size under minimal statistical assumptions. Moreover, we prove that our approach, which reduces to an efficiently solvable convex optimization problem, can be related to Variational Bayesian inference on the binary connection weights, and we derive rigorous bounds on the posterior marginals. This allows us to extend our method to the streaming setting, where continuously updated posteriors allow for optional stopping, and we demonstrate the feasibility of inferring connectivity for networks of up to tens of thousands of neurons online. Finally, we show how our work can be theoretically linked to compressed sensing approaches, and compare results for connectivity inference in different settings., Comment: Revised and expanded version of the work that appeared in NeurIPS 2020

Published
2020

28. Unified equations of state for cold non-accreting neutron stars with Brussels-Montreal functionals. II. Pasta phases in semi-classical approximation

Author

Pearson, J. M., Chamel, N., and Potekhin, A. Y.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Nuclear Theory
Abstract

We generalize our earlier work on neutron stars (arXiv:1903.04981), which assumed spherical Wigner-Seitz cells in the inner crust, to admit the possibility of pasta phases, i.e., non-spherical cell shapes. Full fourth-order extended Thomas-Fermi calculations using the density functional BSk24 are performed for cylindrical and plate-like cells. Unlike in our spherical-cell calculations, we do not include shell and pairing corrections, but there are grounds for expecting these corrections for pasta to be significantly smaller. It is therefore meaningful to compare the ETF pasta results with the full spherical-cell results, i.e., with shell and pairing corrections included. However, in view of the many previous studies in which shell and pairing corrections were omitted entirely, it is of interest to compare our pasta results with the ETF part of the corresponding spherical calculations. Making this latter comparison we find that as the density increases the cell shapes pass through the usual sequence sphere $\to$ cylinder $\to$ plate before the transition to the homogeneous core. The filling fractions found at the phase transitions are in close agreement with expectations based on the liquid-drop model. On the other hand, when we compare with the full spherical-cell results, we find the sequence to be sphere $\to$ cylinder $\to$ sphere $\to$ cylinder $\to$ plate. In neither case do any "inverted", i.e., bubble-like, configurations appear. We provide accurate fitting formulas to all our essential numerical results for each of the three phases, designed especially for the density range where the nonspherical shapes are expected, which enable one to capture not only the general behavior of the fitted functions, but also the differences between them in different phases., Comment: 16 pages, 14 tables, 8 figures, accepted by Phys. Rev. C

Published
2020
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29. Crystallization of the inner crust of a neutron star and the influence of shell effects

Author

Carreau, T., Gulminelli, F., Chamel, N., Fantina, A. F., and Pearson, J. M.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Nuclear Theory
Abstract

Context. In the cooling process of a non-accreting neutron star, the composition and properties of the crust are thought to be fixed at the finite temperature where nuclear reactions fall out of equilibrium. A lower estimation for this temperature is given by the crystallization temperature, which can be as high as $\approx 7\times 10^9$ K in the inner crust, potentially leading to sizeable differences with respect to the simplifying cold-catalyzed matter hypothesis. Aims. We extend the recent work by Fantina et al. (2019) on the outer crust, to the study of the crystallization of the inner crust and the associated composition in the one-component plasma approximation. Methods. The finite temperature variational equations for non-uniform matter in both the liquid and the solid phases are solved using a compressible liquid-drop approach with parameters optimized on four different microscopic models which cover the present uncertainties in nuclear modeling. Results. We consider separately the effect of the different nuclear ingredients with their associated uncertainties, namely the nuclear equation of state, the surface properties in the presence of a uniform gas of dripped neutrons, and the proton shell effects arising from the ion single-particle structure. Our results suggest that the highest source of model dependence comes from the smooth part of the nuclear functional. Conclusions. We show that shell effects play an important role at the lowest densities close to the outer crust, but the most important physical ingredient to be settled for a quantitative prediction of the inner crust properties is the surface tension at extreme isospin values., Comment: 9 pages, 9 figures

Published
2019
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30. Co-occurrence of biodiversity, carbon storage, coastal protection, and fish and invertebrate production to inform global mangrove conservation planning

Author

Sievers, Michael, Brown, Christopher J., McGowan, Jennifer, Turschwell, Mischa P., Buelow, Christina A., Holgate, Briana, Pearson, Ryan M., Adame, Maria F., Andradi-Brown, Dominic A., Arnell, Andy, Mackey, Brendan G., Ermgassen, Philine S.E. zu, Gosling, Joe, McOwen, Chris J., Worthington, Thomas A., and Connolly, Rod M.

Published
2023
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34. Extracorporeal Life Support Organization Registry International Report 2022: 100,000 Survivors

Author

Tonna, Joseph E., Boonstra, Philip S., MacLaren, Graeme, Paden, Matthew, Brodie, Daniel, Anders, Marc, Hoskote, Aparna, Ramanathan, Kollengode, Hyslop, Rob, Fanning, Jeffrey J., Rycus, Peter, Stead, Christine, Barrett, Nicholas A., Mueller, Thomas, Gómez, Rene D., Malhotra Kapoor, Poonam, Fraser, John F., Bartlett, Robert H., Alexander, Peta M.A., Barbaro, Ryan P., Abbasi, Adeel, Said Abdalmohsen, Ahmad, Abdelbary, Akram M., Abecasis, Francisco, Abel, Peter, Abu-Omar, Yasir, Adams, Douglas R, Manuel Africano, Juan, Aganga, Devon, Agati, Salvatore, Agerstrand, Cara, Aguillon, Mario V., Akers, Crystal S., Akhtarekhavari, Julia, Alazzam, Mohammad Izzat Salah, Albert, Martin, Alberti, Angela, Al-Fares, Abdulrahman A., Alfoudri, Huda, Allaert, Silvie, Allbert, Keesha N., Allen, Christopher T., Lescano Alva, Miguel Ángel, Alwardt, Cory M., Amigoni, Angela, Anandamurthy, Balaram, Anastasiadis, Kyriakos, Anders, Nicholas R., Anderson, Scott A., Anderson, Patricia L., Andrijević, Ana, Annoni, Alice, Anselmi, Michael, Anstey, James R., Antonini, Marta V., Antonitsis, Polychronis, Stein Araujo, Tays, Arcalas, Rhodney, Areinamo, Igor, Martin Arias, Anibal, Armijo-Garcia, Veronica, Aronsky, Vladimir, Arora, Lovkesh, Arora, Madhur, Leigh Aspenleiter, Marit, Atik, Fernando A., AugustGeorg Auzinger, Erin Colleen, Azzam, Ismail, Bacchetta, Matthew, Bak, Erica I., Balcells, Joan, Sánchez Ballesteros, Jesús, Banjac, Igor S., Barbaria, Jacqueline M., Barrigoto, Cleide L., Bass, Stephanie D., Batranović, Uroš, Bauer, Matthew H., Fernando Bautista, Diego, Beck, Robert M., Giraldo Bejarano, Estefania, Belohlavek, Jan, Bembea, Melania M., Benes, Jan, Benharash, Peyman, Benish, Lynne A., Bennett, Suzanne, Bento, Luís F.N., Bermudez, Christian A., Bertini, Pietro, Best, Derek, Bharat, Ankit, Bhutta, Omar J., Bizzell, Samantha J., Blakeman, Stephanie A., Blanco-Schweizer, Pablo, Blanton, Jessica K., Blood, Peggy S., Bohlmann, Allison S., Kyle Bohman, John, Bombino, Michela, Kathleen Bonadonna, Desiree, Bond, Ashley, Borgmann, Kristina M., Bourgoin, Pierre, Boville, Brian M., Boza, Raquel, Brady, Heather L., Brady, Alison, Braunlich, Jessica M., Bridges, Brian C., Brinkley, Karen K., Brookshire, Robert S., Brozzi Nicole Brueggemann, Nicolas A., Buckley, Dwight P., Jr., Buckley, Klayton, Budhani, Irfan B., Bukamal, Nazar, Burgos, Lucrecia M, Burša, Filip, Busby, Landon K., Buscher, Hergen, Butler, Menoly, Butt, Warwick W., Byrnes, Jonathan W., Calaritis, Christos, Caldwell, Lisa R., Calligaro, Gregory L., Campbell, Patrick T., Camporota, Luigi, Fernando Caneo, Luiz, Jovo Carapic, Vladimir, Carrasco-Carrasco, Cristina, Ivan Carrizo, Nestor, Carrow, Heidi, Carton, Edmund G., Casabella, Christian, Gomez Casal, Vanesa, Casey, Francis L., III, Castillo, Andres, Castleberry, Anthony W., Alexandros Cavayas, Yiorgos, Cerqua, Karey, Ming Chan, Kai Man ChanWai, Brian Chapman, Jason, Brahma Chari, Hari, Cheifetz, Omair ChaudharyIra M., Chen, Robin H.S, Chen, Weiting, Cheung, Eva W., Cheung, Anson, Chico, Juan I., Chiletti, Roberto, Jin Cho, Hwa, Cholette, Jill M., Christensen, Steffen, Chui, Betty S., Circelli, Alessandro, Clement, Katherine C., Cleuziou, Julie, Clouse, Brian, Cole, Gwendolen, Coles, Garrett M., Collins, Monika F., Collins, Monika F., Connelly, James, Conrad, Steven A., Cook, Marlene, Copeland, Hannah, Copus, Scott C., Cox, Charles S., Jr, Craig, Lynne K., Crain, Natasha, Cremonese, Ricardo V., Criswell, Emily A., Cross, Lisa M., Crowley, Moira A., Crowley, Jerome C., Cruz, Leonora, Cypel, Marcelo, Czarnik, Tomasz, Czuczwa, Miroslaw E., Sica da Rocha, Taís, Daddow, Samuel, Dali, Dante C., Dalton, Heidi J., Daly, Kathleen J.R., Damuth, Emily, Daniel, Dennis A., Daniel IV, John M., Daniel, Josiane M., Danis, Max D., Danko, Melissa E., Rodrigues Dantas, Joao Alberto, Daoust, Isabelle, Dauwe, Dieter F., Davidson, Mark, Davis, Joel C., Davis, Mitchell, D’Cunha, Jonathan, de Arruda Bravim, Bruno, de BoodeKim T. De La Cruz, Willem P., Gray DeAngelis, Kathryn, Debeuckelaere, Gerdy, Deitemyer, Matthew A., DellaVolpe, Jeffrey, Deneau, Jamie L., DeNino, Walter F., Denmark, Christopher G., Denney, Derek, DeValeria, Patrick A., Dewulf, Petra, Di Nardo, Matteo, DiBardino, Daniel J., DiMartino, Joseph, Dimopoulos, Stavros, Domico, Michele B., Dominy, Meaghan E., Donker, Dirk W., Dresbach, Till, Droogh, Joep M., Dunlap, Tiffany W., Dupon, Allsion, Durham, Lucian A., III, Durward, Andrew, Dvorak, Anna, Dyett, John F., Dziedzina, Carol L., Eaken, Carmen L., Eaton, Jonathan S., Eberle, Christopher J., Edwards, Linda, Efseviou, Christakis, Eigner, Juliann M., Ahmed Elhamrawi, Hazem, Elhazmi, Alyaa M., Elizondo, Tammy, Ellersick, Beverly L., Emling, Jonathan A., Ernst, Andreas, Pablo Escalante, Juan, Espinoza, Otoniel, Evey, Lee W., Fan, Eddy, Fang, Gary, Faulkner, Gail M., Fauman, Karen R, Ferguson, Niall, Ferreira, Benigno, Fiane, Arnt E., Andrade Fierro, Dario, Martha Filippi, María, Findeisen, Michael C., Finlay, Katie, Finlayson, Gordon, Fischer, Gwenyth A., Fischer, Courtney D., Fischer, William J., III, Fisher, Caleb M., Fitriasari, Reni, Fitzgerald, Jillian, Fix, Melissa K., Fleming, Sarah B., Flynn, Brigid C., Forst, Beth A., Fortuna, Philip P., Foti, Giuseppe, Fox, Matthew P., Franco, Thais O., David Freeland, C., Fried, Justin A., Friedman, Matthew L., Furlanetto, Beatriz, Fux, Thomas, Gaião, Sérgio, Gale, Michael J., Garcia, Joann Kathleen G., Garcia-Montilla, Romel, Gardner, Eric R., Garg, Meena, Garrison, Lawrence L., Gavrilovic, Srdjan M., Gawda, Ryszard, Geer, Laura W., Gelandt, Elton A., Gelvin, Michael G., Genovese, Bradley M., George, Jeffrey A., George, Timothy J, George, Sangley, Ghimire, Anup, Giani, Marco, Gill, Baljit S., Glikes, Erin, Golecki, Michael, Gongora, Enrique, Govener, Sara, Graf, Amanda, Grasselli, Giacomo, Gray, Brian W., Greenlee, Joseph A., III, Gregoric, Igor D., Gregory, Melinda, Grins, Edgars, Volker Groesdonk, Heinrich, Group, Kimberly F., Guarracino, Fabio, Joy Guidi-Solloway, Alexandra, Gunn, Tyler M., Guru, Pramod K, Haddle, John C., Haft, Jonathan W., Haisz, Emma, Hall, Julie L., Hall, Cameron, Hamaguchi, Jun, Hammond, Terese C., Han, Peggy K., Hardison, Daphne C., Harischandra, Dickwelle T., Hart, Shaun M., Harting, Matthew T., Hartley, Louise, Harvey, Chris J., Hasan, Zubair, Fawzy Hassan, Ibrahim, Hastings, Jennifer R., Hatcher, Renee’, Hatton, Kevin W., Haught, Christopher K., Awori Hayanga, Jeremiah, Peter Haydon, Timothy, Healy, Aaron H., Heard, Micheal L., Heather, Beth M., Hendrix, Rik H.J., Hennig, Felix, Hermens, Greet HermansJeannine A.J., Hernandez, Deborah A., Hernandez-Montfort, Jaime, Herrera, Guillermo, Hickman, Keri, Hittel, Ashley, Hobbs, Crystal, Hoffman, Jordan R.H., Hollinger, Laura E., Homishak, Michael, Horigoshi, Nelson K., Hoshino, Kota, Huang, Shu-Chien, Huenges, Katharina, Hussey, Alexander D., Hyslop, Robert W., Ihle, Rayan E., Ingemansson, Ola, Ivulich, Daniel, Jackson, Amanda L., Garcia Jacques, Rogelio, Jain, Harsh, Jakobs, Sharon M., Jan, Robert, Janowiak, Lisa M., Jara, Claire B., Jarden, Angela M., Jarzembowski, Jamie L., Jaudon, Andrew, Kishore Jayanthi, Venkata Krishna, Jennings, Joseph A., Jeong, Inseok, Meza Jiménez, Rafael, Jimenez-Rodriguez, Gian M., Joachim, Sabrina, Joelsons, Daniel, Johnson, Caroline A., Johnson, Andrea L., Jones, Jeffry H., Joseph, Mark, Joseph, Sunimol, Joshi, Raja, Joyce, Christopher J., Seung Jung, Jae, Carone Junior, José, Kallas, Harry J., KamerkarPilje Kang, Asavari, Kar, Biswajit, Karapanagiotidis, Georgios T., Kattan, Javier, Kaufman, David A., Kawauchi, Akira, Keene, Sarah D., Keller, Norma M., Keller, Roberta, Kelley, Emily W., Kelley, Kellie, Kelly-Geyer, Janet F., Kenderessy, Peter, Kenny, Laura E., Keshavjee, Shaf, Kessel, D., Kessler, Heather, Keuler, Suzanne, Khicha, Sanjay, Wan Kim, Do, Kim, Richard Y., Maxwell Kime, Aaron, Kincade, Robert C., Kipfmueller, Florian, Kirk, Douglas A., Klein, Liviu, Knapp, Randall S., Knapp, Randall S., Kneyber, Martin C.J., Knowles, Andrea L., Koch, Jillian M., Koepke, Stephanie, Kogelmann, Klaus M., Elzo Kraemer, Carlos, Krauklis, Amanda, Krumroy, Samantha L., Kumar, Madhan, Kumar, Arun, Kumpf, Matthias E, Kyle, Kimberly, Laffin, Anna, Kees Lagrand, Wim, Lahiji, Parshawn A., Keung Lai, Peter Chi, Ka Lai, Cally Ho, Danielle Laird, Amanda, Landsberg, Michelle LaMarreDavid M., Lanmueller, Pia, Oude Lansink-Hartgring, Annemieke, Beth Larson, Sharon, Laufenberg, De’Ann M., Lavana, Jayshree, Layne, Tracie L., John Lazar, Michael, Ledoux, Matthew R., Lee, Raymond C., Leek, Thomas M., Lequier, Laurance, Lesbekov, Timur, Leslie, Robert, Anne Leung, Kit Hung, Lillie, Jon, Phang Lim, Yeong, Lim, Sang-Hyun, Lin, Ling, Lindsey, Thomas, Ho Ling, Steven Kin, Lingle, Kaitlyn J., Lipes, Jed, Liu, Songqiao, Llevadias, Judit, Lomas, Erin A., Longenecker, Robert D., Lorusso, Roberto, Ann Low, Tracy, Steven Lubinsky, Anthony, Lucas, Matthias LubnowMark T., Lucchini, Alberto, Luze, Lisa E., Lynch, William R., Manoj, M.C., Maas, Jacinta J., MacNamara, Vanessa, Madden, Jesse L., Maimone, Justin, Malhotra, Rajiv, Malone, Matthew P., Mangukia, Chirantan, Manzur-Sandoval, Daniel, Maráczi, Veronika, Marinaro, Jonathan L., Marinucci, Christina R., Marshall, Tammy, Martin, Mark, Marwali, Eva M., Maslach-Hubbard, Anna, Matijašević, Jovan, Mattke, Adrian, Mattucci, Joseph, Maul, Timothy M., Maybauer, Marc O., Mayette, Michael, Mayville, Joni R., McAllister, Catherine, McBride, Martha W., Scott McCaul, David, McClelland, Samantha L.S., Gregory McCloskey, Colin, McGregor, Randy, McKamie, Wesley A., McKee, Andrew D., McMahon, Chelsea M., McMullin, Kaye, McNicol, Jane, McNulty, John P., McRae, Thomas, Meade, Maureen E., Meersseman, Philippe, Mekeirele, Michael, Ito Mendes, Elisa, Menon, Anuradha P., Meyer, Jason P., Meyers, Jourdan E., Meyns, Bart, Mignone, John L., Miller, Brittany D., Miller, Malcolm G.A., Miller, Deborah, Mintak, Renee, Minter, Sarah M., Reis Miranda, Dinis, Mirza, Farrukh, Mishkin, Joseph D., Modelewski, Paul, Mohan, Rajeev C., Hui Mok, Yee, Money, Dustin, Monteagudo, Julie, Moores, Russell R., Jr., Moran, Patrick, Morelock, Shawn, Moreno, Marsha R., Blanco Morillo, Juan, Morrison, Tracy, Morton, John M., Morton, Brenda, Moscatelli, Andrea, Mosier, Jarrod M., Muellenbach, Ralf M., Mueller, Andreas, Mueller, Dale, Musca, Steven C., Nagpal, Dave, Najaf, Tasnim, Narasimhan, Mangala, Nater, Melissa, Natividad, Zynthia, Nedeljkov, Djordje, Nelson, Bryan D., Newman, Sally F., Newton, Debra E., Neyman, Jonathan L., George Ng, Wing Yiu, Nicholson, Meghan C., Nicolaas, Christine, Nix, Charlie, Nkwantabisa, Raymond, Nolan, Shirley, Norese, Mariano, Norton, Bridget M., Norton, Bridget M., O’Brien, Serena G., O’Callaghan, Maura, Oishi, Peter, O’Leary, Tony D., Olia, Salim E., O’Meara, Carlisle, Oppel, Emily E., Arias Ortiz, Julian, Oza, Pranay L., Ozment, Caroline P., Pacific, Marjorie, Pálizas, Fernando, Palmer, David, Paoletti, Luca, Pardo, Diego H., Paredes, Pablo, Patel, Thomas PasgaardMrunal G., Patel, Sandeep M., Patel, Vijay S., Patel, Brijesh V., PatelDrisya Paul, Sameer, Pawale, Amit A., Pearson, Nicole M., Renee Pearson, Crystal, Peek, Giles J., Pellecchia, Crescens M., Pellegrino, Vincent, Peperstraete, Harlinde, Perkins, Rebecca L., Perkins, Brandon, Peterec, Steven, Peterman, Claire, Phillips, Cooper W., Piekutowski, Richard R., Pilan, María L., Luisa Pilan, Maria, Mark Pincus, Jason, Pino, Melissa, Plambeck, Robert W., Plisco, Michael S., Plumley, Donald A., Plunkett, Mark D., Poffo, Robinson, Poh, Pei-Fen, Polito, Angelo, Pollema, Travis L, Pozzi, Matteo, Pozzi, Matteo, Pranikoff, Thomas, Prekker, Matthew E., Prossen, Erik F., Puligandla, Pramod S., Puslecki, Mateusz, Raheel Qureshi, Muhammad, Emilia Rabanal, Lily, Abdulhamid Rabie, Ahmed, Rackley, Craig R., Radovancevic, Rajko, Raes, Matthias, Allen Raff, Lauren Desiree, Rahban, Youssef, Raimer, Patricia L., Rajbanshi, Bijoy G., Ramanan, Raj, Rambaud, Jerome, Ramírez-Arce, Jorge A., Simões Ramos, Ana Carolina, Rao, Suresh G., Rector, Raymond, Redfors, Bengt, Regmi, Ashim, Alejandro Rey, Jose, Miguel Ribeiro, Joao, Richards, Chelsea E, Joan Richardson, C., Riddle, Christy C., Riera, Jordi, Ripardo, Marina, Rivas, Fernando M., Roan, Ronald M., Robertson, Elizabeth, Robinson, Megan, Röder, Daniel, Rodrigus, Inez E.R., Paul Roeleveld, Peter, Romano, Jennifer C., Rona, Roberto, Ann Rosenberg, Carol, Rosenow, Felix, Rowe, Robert J., Rower, Katy E., Rudolph, Kristina L., Fernando Rueda, Luis, Ruf, Bettina, Russell, Hyde M., Russell, Nichole, Ryan, Kathleen, Saberi, Asif A., Said, Ahmed S., Sailor, Caitlin, Sakal, Angela, Lujan Salas, Gisela, Salazar, Leonardo, Saleem, Kashif, Samoukovic, Gordan, Sanchez, Pablo G., Marie Santiago, Lian, Sargin, Murat, Miguel Sassine, Assad, Satou, Nancy L., Saunders, Paul C., Schachinger, Scott, Schaible, Thomas, Schellongowski, Peter, Schlager, Gerald W., Schmid, Christof, Schmitt, Joachim, Schnell, LeeAndra, Schnur, Janos, Schroeder, Lukas, Schubach, Scott, Schuetz, Michael T., Schwartz, Gary S., Schwarz, Patricia, Scriven, Nicole M., Seabrook, Ruth B., Seefeldt, Cassandra, Seelhammer, Troy G., Segura-Matute, Susana, Sen, Ayan, Adrian Seoane, Leonardo, Shaffer, Jamie, Shafi, Bilal M., Shambley, Shannon, Shankar, Shyam, Shapland, Amanda, Sharng, Yih, Shavelle, David, Sheldrake, Jayne, Mohan Shetty, Rajesh, Shiber, Joseph R., Shimzu, Naoki, Lou Short, Billie, Sichting, Kay A., Sidehamer, Keith E., Siebenaler, Teka, Silvestry, Scott C., Sinclair, Jennifer T, Sinclair, Andrew, Singh, Aalok R., Singh, Gurmeet, Skinner, Sean C., Smart, Alexandra, Smith, Reanna M., Smith, Adam, Smith, Karen, Sommer-Candelario, Sherri, Song, Seunghwan, Sorensen, Gro, Sousa, Eduardo, Sower, Christopher T., Spadea, Nicholas V, Spangle, April, Speicher, David G., Spieth, Peter M., Srivastava, Ankur, Srivastava, Neeraj, Stahl, Mark, Stallkamp, Eric D., Jr, Stanley, Vanessa J., Starr, Joanne P., Staudinger, Thomas, Stevens, Berkeley E., Stevens, Kimberly, Stocker, Christian, Strickland, Richard, Suarez, Erik E., Kumar Subramanian, Rakesh, Sudakevych, Serhii, Summerall, Charlene, Sundararajan, Santosh, Susupaus, Attapoom, Suzuki, Hiroyuki, Sweberg, Todd, Sydzyik, Troy, Anh Ta, Tuan, Tagliari, Luciana, Tanaka, Hiroyuki, Tanski, Christopher T., Tasset, Mark, Taylor, Donna M., Teman, Nicholas R., Ramesh Thangaraj, Paul, Thiagarajan, Ravi R., Thiruchelvam, Timothy, Thomas, James A., Thomas, Owain D., Thompson, Shaun L., Thomson, David A., Thukaram, Roopa, Todd, Mark L., Toeg, Hadi, Torres, Silvio F., Trautner, Simon, Trombino, Terry, Tuazon, Divina M., Tuel, Julie, Tukacs, Monika, Turner, April N., Tyree, Melissa M., Uchiyama, Prashant Vaijyanath, Makoto, van den Brule, Judith M.D., van Dyck, Marlice A., van Gijlswijk, Mascha, Van Meurs, Krisa P., VanDyck, Tyler J., Vardi, Amir, Vega, Alejandra, Ventetuolo, Corey E., Vera, Magdalena, Vercaemst, Leen, Vets, Philippe, Viamonte, Heather, Vidlund, Mårten, Vitali, Sally H., Vlaa, Alexander P.J., Vuylsteke, Alain, Loon Wan, Kah, Watkins, Reuben, Watson, Pia, Weast, Travis A., Weaver, Karen E., Welkovics, Norbert, Wellner, Heidi L., Wells, Jason C., Welter, Karen, Westpheling, Amber G., Whalen, Lesta D.S., Whebell, Stephen, Wiersema, Ubbo, Wiisanen, Matthew E., Eugene Wilcox, Bradley, Wille, Keith, Jan Will, Ellyne, Wilson, Brock J., Win, April M., Winearls, James R., Wise, Linda J., Witter, Tobias, Ruby Wong, Hoi Mei, Worku, Berhane, Wright, Tina M, Wu, James K., Yalon, Larissa A., Yantosh, Garrett, Yaranov, Dmitry M., Yee, Pat, Yi, Cassia, Yost, Christian C., Young, John, Younger, Katrina, Zaborowski, Steven, Zachmann, Brenda, Zainab, Asma, Zanai, Rosanna, Zhao, Ju, Zhou, Chengbin, and Zinger, Marcia

Published
2024
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37. Shotgun transcriptome, spatial omics, and isothermal profiling of SARS-CoV-2 infection reveals unique host responses, viral diversification, and drug interactions

Author

Butler, Daniel, Mozsary, Christopher, Meydan, Cem, Foox, Jonathan, Rosiene, Joel, Shaiber, Alon, Danko, David, Afshinnekoo, Ebrahim, MacKay, Matthew, Sedlazeck, Fritz J, Ivanov, Nikolay A, Sierra, Maria, Pohle, Diana, Zietz, Michael, Gisladottir, Undina, Ramlall, Vijendra, Sholle, Evan T, Schenck, Edward J, Westover, Craig D, Hassan, Ciaran, Ryon, Krista, Young, Benjamin, Bhattacharya, Chandrima, Ng, Dianna L, Granados, Andrea C, Santos, Yale A, Servellita, Venice, Federman, Scot, Ruggiero, Phyllis, Fungtammasan, Arkarachai, Chin, Chen-Shan, Pearson, Nathaniel M, Langhorst, Bradley W, Tanner, Nathan A, Kim, Youngmi, Reeves, Jason W, Hether, Tyler D, Warren, Sarah E, Bailey, Michael, Gawrys, Justyna, Meleshko, Dmitry, Xu, Dong, Couto-Rodriguez, Mara, Nagy-Szakal, Dorottya, Barrows, Joseph, Wells, Heather, O’Hara, Niamh B, Rosenfeld, Jeffrey A, Chen, Ying, Steel, Peter AD, Shemesh, Amos J, Xiang, Jenny, Thierry-Mieg, Jean, Thierry-Mieg, Danielle, Iftner, Angelika, Bezdan, Daniela, Sanchez, Elizabeth, Campion, Thomas R, Sipley, John, Cong, Lin, Craney, Arryn, Velu, Priya, Melnick, Ari M, Shapira, Sagi, Hajirasouliha, Iman, Borczuk, Alain, Iftner, Thomas, Salvatore, Mirella, Loda, Massimo, Westblade, Lars F, Cushing, Melissa, Wu, Shixiu, Levy, Shawn, Chiu, Charles, Schwartz, Robert E, Tatonetti, Nicholas, Rennert, Hanna, Imielinski, Marcin, and Mason, Christopher E

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Clinical Sciences, Infectious Diseases, Vaccine Related, Biodefense, Rare Diseases, Emerging Infectious Diseases, Clinical Research, Prevention, Lung, Pneumonia & Influenza, Aetiology, Development of treatments and therapeutic interventions, 2.1 Biological and endogenous factors, 5.1 Pharmaceuticals, Infection, Good Health and Well Being, Adult, Aged, Angiotensin Receptor Antagonists, Angiotensin-Converting Enzyme Inhibitors, Antiviral Agents, COVID-19, COVID-19 Nucleic Acid Testing, Drug Interactions, Female, Gene Expression Profiling, Genome, Viral, HLA Antigens, Host Microbial Interactions, Humans, Male, Middle Aged, Molecular Diagnostic Techniques, New York City, Nucleic Acid Amplification Techniques, Pandemics, RNA-Seq, SARS-CoV-2, COVID-19 Drug Treatment
Abstract

In less than nine months, the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) killed over a million people, including >25,000 in New York City (NYC) alone. The COVID-19 pandemic caused by SARS-CoV-2 highlights clinical needs to detect infection, track strain evolution, and identify biomarkers of disease course. To address these challenges, we designed a fast (30-minute) colorimetric test (LAMP) for SARS-CoV-2 infection from naso/oropharyngeal swabs and a large-scale shotgun metatranscriptomics platform (total-RNA-seq) for host, viral, and microbial profiling. We applied these methods to clinical specimens gathered from 669 patients in New York City during the first two months of the outbreak, yielding a broad molecular portrait of the emerging COVID-19 disease. We find significant enrichment of a NYC-distinctive clade of the virus (20C), as well as host responses in interferon, ACE, hematological, and olfaction pathways. In addition, we use 50,821 patient records to find that renin-angiotensin-aldosterone system inhibitors have a protective effect for severe COVID-19 outcomes, unlike similar drugs. Finally, spatial transcriptomic data from COVID-19 patient autopsy tissues reveal distinct ACE2 expression loci, with macrophage and neutrophil infiltration in the lungs. These findings can inform public health and may help develop and drive SARS-CoV-2 diagnostic, prevention, and treatment strategies.

Published
2021

38. Development of a mapping function ("crosswalk") for the conversion of scores between the Oswestry Disability Index (ODI) and the Core Outcome Measures Index (COMI)

Author

Mannion, A. F., Elfering, A., Fekete, T. F., Pizones, J., Pellise, F., Pearson, A. M., Lurie, J. D., Porchet, F., Aghayev, E., Vila-Casademunt, A., Mariaux, F., Richner-Wunderlin, S., Kleinstück, F. S., Loibl, M., Pérez-Grueso, F. S., Obeid, I., Alanay, A., Vengust, R., Jeszenszky, D., and Haschtmann, D.

Published
2022
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42. Role of Landau-Rabi quantization of electron motion on the crust of magnetars within the nuclear energy density functional theory

Author

Mutafchieva, Y. D., Chamel, N., Stoyanov, Zh. K., Pearson, J. M., and Mihailov, L. M.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Nuclear Theory
Abstract

Magnetic fields of order $10^{15}$ G have been measured at the surface of some neutron stars, and much stronger magnetic fields are expected to be present in the solid region beneath the surface. The effects of the magnetic field on the equation of state and on the composition of the crust due to Landau-Rabi quantization of electron motion are studied. Both the outer and inner crustal regions are described in a unified and consistent way within the nuclear-energy density functional theory., Comment: 23 pages, 11 figures

Published
2019
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43. Unified equations of state for cold non-accreting neutron stars with Brussels-Montreal functionals. I. Role of symmetry energy

Author

Pearson, J. M., Chamel, N., Potekhin, A. Y., Fantina, A. F., Ducoin, C., Dutta, A. K., and Goriely, S.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Nuclear Theory
Abstract

The theory of the nuclear energy-density functional is used to provide a unified and thermodynamically consistent treatment of all regions of cold non-accreting neutron stars. In order to assess the impact of our lack of complete knowledge of the density dependence of the symmetry energy on the constitution and the global structure of neutron stars, we employ four different functionals. All of them were precision fitted to essentially all the nuclear-mass data with the Hartree-Fock-Bogoliubov method and two different neutron-matter equations of state based on realistic nuclear forces. For each functional, we calculate the composition, the pressure-density relation, and the chemical potentials throughout the star. We show that uncertainties in the symmetry energy can significantly affect the theoretical results for the composition and global structure of neutron stars. To facilitate astrophysical applications, we construct analytic fits to our numerical results., Comment: 36 pages, 31 figures, 29 tables; corrected according to an erratum (2019, accepted)

Published
2019
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44. Depression and Incident HIV in Adolescent Girls and Young Women in HIV Prevention Trials Network 068: Targets for Prevention and Mediating Factors

Author

Goin, Dana E, Pearson, Rebecca M, Craske, Michelle G, Stein, Alan, Pettifor, Audrey, Lippman, Sheri A, Kahn, Kathleen, Neilands, Torsten B, Hamilton, Erica L, Selin, Amanda, MacPhail, Catherine, Wagner, Ryan G, Gomez-Olive, F Xavier, Twine, Rhian, Hughes, James P, Agyei, Yaw, Laeyendecker, Oliver, Tollman, Stephen, and Ahern, Jennifer

Subjects
Mental Health, HIV/AIDS, Behavioral and Social Science, Depression, Prevention, Clinical Research, Brain Disorders, Pediatric, Clinical Trials and Supportive Activities, Infectious Diseases, Prevention of disease and conditions, and promotion of well-being, 3.1 Primary prevention interventions to modify behaviours or promote wellbeing, Infection, Good Health and Well Being, Adolescent, Female, HIV Infections, Humans, Incidence, Motivation, Risk Factors, Sexually Transmitted Diseases, Viral, South Africa, Students, Unsafe Sex, Young Adult, adolescent health, depression, Mathematical Sciences, Medical and Health Sciences, Epidemiology
Abstract

The human immunodeficiency virus (HIV) epidemic among adolescent girls and young women (AGYW) in sub-Saharan Africa is a critical public health problem. We assessed whether depressive symptoms in AGYW were longitudinally associated with incident HIV, and identified potential social and behavioral mediators. Data came from a randomized trial of a cash transfer conditional on school attendance among AGYW (ages 13-21 years) in rural Mpumalanga Province, South Africa, during 2011-2017. We estimated the relationship between depressive symptoms and cumulative HIV incidence using a linear probability model, and we assessed mediation using inverse odds ratio weighting. Inference was calculated using the nonparametric bootstrap. AGYW with depressive symptoms had higher cumulative incidence of HIV compared with those without (risk difference = 3.5, 95% confidence interval (CI): 0.1, 7.0). The strongest individual mediators of this association were parental monitoring and involvement (indirect effect = 1.6, 95% CI: 0.0, 3.3) and reporting a partner would hit her if she asked him to wear a condom (indirect effect = 1.5, 95% CI: -0.3, 3.3). All mediators jointly explained two-thirds (indirect effect = 2.4, 95% CI: 0.2, 4.5) of the association between depressive symptoms and HIV incidence. Interventions addressing mental health might reduce risk of acquiring HIV among AGYW.

Published
2020

45. Structure-specific amyloid precipitation in biofluids

Author

Rodrigues, M., Bhattacharjee, P., Brinkmalm, A., Do, D. T., Pearson, C. M., De, S., Ponjavic, A., Varela, J. A., Kulenkampff, K., Baudrexel, I., Emin, D., Ruggeri, F. S., Lee, J. E., Carr, A. R., Knowles, T. P. J., Zetterberg, H., Snaddon, T. N., Gandhi, S., Lee, S. F., and Klenerman, D.

Published
2022
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50. Crustal heating in accreting neutron stars from the nuclear energy-density functional theory. I. Proton shell effects and neutron-matter constraint

Author

Fantina, A. F., Zdunik, J. L., Chamel, N., Pearson, J. M., Haensel, P., and Goriely, S.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Nuclear Theory
Abstract

Observations of soft X-ray transients in quiescence suggest the existence of heat sources in the crust of accreting neutron stars. Heat is thought to be released by electroweak and nuclear processes triggered by the burying of ashes of X-ray bursts. The heating is studied using a fully quantum approach taking consistently into account nuclear shell effects. We have followed the evolution of ashes made of $^{56}$Fe employing the nuclear energy-density functional theory. Both the outer and inner crusts are described using the same functional, thus ensuring a unified and thermodynamically consistent treatment. To assess the role of the neutron-matter constraint, we have employed the set of accurately calibrated Brussels-Montreal functionals BSk19, BSk20, and BSk21 and for comparison the SLy4 functional. Due to nuclear shell effects, the fully accreted crust is found to be much less stratified than in previous studies. In particular, large regions of the inner crust contain clusters with the magic number $Z=14$. The heat deposited in the outer crust is tightly constrained by experimental atomic mass data. The shallow heating we obtain does not exceed $0.2$~MeV and is therefore not enough to explain the cooling of some soft X-ray transients. The total heat released in the crust is very sensitive to details of the nuclear structure and is predicted to lie in the range from $1.5$~MeV to $1.7$~MeV. The evolution of an accreted matter element and therefore the location of heat sources are governed to a large extent by the existence of nuclear shell closures. Ignoring these effects in the inner crust, the total heat falls to $\sim 0.6$~MeV. The neutron-matter constraint is also found to play a key role. The large amount of heat obtained by Steiner et al. (2012) could thus be traced back to unrealistic neutron-matter equations of state., Comment: 20 pages, 13 figures, submitted to A&A

Published
2018
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