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2. Validation of extracorporeal membrane oxygenation mortality prediction and severity of illness scores in an international COVID-19 cohort
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Shah, N, Xue, B, Xu, Z, Yang, H, Marwali, E, Dalton, H, Payne, P, Lu, C, Said, A, Abdukahil, S, Abdulkadir, N, Absil, L, Acker, A, Adriao, D, Hssain, A, Akwani, C, Qasim, E, Alalqam, R, Al-Dabbous, T, Alex, B, Al-Fares, A, Alfoudri, H, Aliudin, J, Alves, J, Alves, R, Cabrita, J, Amaral, M, Amira, N, Andini, R, Anthonidass, S, Antonelli, M, Arabi, Y, Arcadipane, A, Arenz, L, Arnold-Day, C, Arora, L, Arora, R, Ashraf, M, Asyraf, A, Atique, A, Bach, B, Baillie, J, Bak, E, Bakar, N, Balakrishnan, M, Barbalho, R, Barclay, W, Barnett, S, Barnikel, M, Barrasa, H, Barrigoto, C, Baruch, J, Hassin Basri, M, Battaglini, D, Bautista Rincon, D, Bee, K, Begum, H, Beljantsev, A, Benjiman, L, Bento, L, Bernal Sobrino, J, Bertolino, L, Bhatt, A, Bianco, C, Bidin, F, Humaid, F, Bin Kamarudin, M, Blanco-Schweizer, P, Bloos, F, Boccia, F, Bogaert, D, Borges, D, Bouhmani, D, Bouziotis, J, Boylan, M, Bozza, F, Brazzi, L, Brewster, D, Brickell, K, Broadley, T, Brozzi, N, Buchtele, N, Burrell, A, Cabral, S, Garces, R, Calligy, K, Campbell, P, Cardoso, S, Cardoso, F, Carelli, S, Carrier, F, Carson, G, Cascao, M, Casimiro, J, Castanheira, N, Castro, I, Catarino, A, Cavalin, R, Cavalli, G, Cavayas, A, Chand, M, Chen, A, Chen, Y, Cheng, M, Chica, J, Chidambaram, S, Tho, L, Cho, S, Chow, T, Chua, H, Chua, J, Cidade, J, Citarella, B, Ciullo, A, Clarke, J, Clohisey, S, Codan, C, Coles, J, Colombo, S, Connor, M, Cooke, G, Corley, A, Cornelis, S, Corpuz, A, Crump, J, Cruz, C, Cruz Bermudez, J, Rojo, J, Csete, M, Cullen, A, Cummings, M, Curley, G, Custodio, P, Filipe, A, Dabaliz, A, Dagens, A, Dahly, D, Dalton, J, Damas, J, Dankwa, E, Dantas, J, de Loughry, G, de Rosa, R, de Silva, T, Deacon, J, Dean, D, Debenedictis, B, Dell'Amore, A, Denis, E, Depuydt, P, Desai, M, Dhangar, P, Diaz, R, Dieperink, W, Docherty, A, Doherty, H, Donnelly, C, Donohue, C, Downer, T, Drake, T, Duculan, T, Dunning, J, Duplaix, M, Durante-Mangoni, E, Durham, L, Ean, S, Echeverria-Villalobos, M, Elotmani, L, Elshazly, T, Eng, C, Escher, M, Santo, C, Estevao, J, Everding, A, Fairfield, C, Faria, P, Fateena, H, Fayed, M, Fernandes, J, Fernandes, M, Fernandes, S, Ferrao, J, Ferraz, M, Ferreira, B, Figueiredo-Mello, C, Fiorda, J, Fletcher, T, Florio, L, Fonseca, T, Forsyth, S, Foti, G, Fowler, R, Fraser, J, Fraser, C, Ribeiro, A, French, C, Fukuda, M, G, A, Gagliardi, M, Gaiao, S, Gamble, C, Gani, Y, Garcia, R, Barrio, N, Gavin, A, Germano, N, Giani, M, Gilroy, E, Girvan, M, Gnall, E, Goffard, J, Goh, J, Golob, J, Gonzalez, A, Graf, J, Grasselli, G, Green, C, Greenhalf, W, Grieco, D, Griffee, M, Griffiths, F, Lordemann, A, Gruner, H, Gu, Y, Guerreiro, D, Castro, M, Hakak, S, Hall, M, Halpin, S, Hamer, A, Hammond, T, Hammond, N, Han, L, Hao, K, Hardwick, H, Ekow Harrison, S, Harrison, E, Harrison, J, Heerman, J, Hendry, R, Hennessy, M, Higgins, D, Higgins, R, Hinton, S, Ho, Y, Ho, A, Hoh, W, Holt, R, Horby, P, Hsu, J, Hurd, A, Ijaz, S, Inacio, H, Ing, Y, Isgett, S, Isidoro, T, Ismail, N, Ivulich, D, Jackson, C, Jelani, A, Joe, O, Joshi, S, Jung, A, Kaisbain, N, Kaleesvran, T, Ayadi Kamaluddin, M, Che Kamaruddin, Z, Kamarudin, N, Kang, K, Karpayah, P, Kartsonaki, C, Kay, C, Keating, S, Kelly, A, Kelly, S, Kennon, K, Khalid, I, Khan, I, Kho, M, Khoo, R, Khoo, D, Khoo, S, Kiat, K, Kida, Y, Kim, J, Kitamura, N, Klenerman, P, Knight, S, Kobbe, R, Krishnan, V, Kumar, D, Kumar, G, Kurtzman, E, Lalueza, A, Lanza, M, Law, A, Lee, T, Lee, H, Lee, B, Lee, Y, Lee, J, Leeming, G, Lene, H, Leone, M, Bassi, G, Lim, K, Lim, W, Lina, L, Liu, K, Loforte, A, Loon, L, Lopes, D, Low, L, Loy, J, Bermejo, C, Lunn, M, Lyons, R, Maasikas, O, Machado, S, de la Calle, G, Maier, L, Malfertheiner, M, Malik, N, Sant'ana Malaque, C, Marino, D, Marques, A, Marsh, B, Marsh, L, Marshall, J, Martin, E, Martinez, F, Martin-Loeches, I, Martins, J, Martins, A, Rego, C, Martucci, G, Marzukie, M, Maynar, J, Mcarthur, C, Mccanny, P, Mccloskey, C, Mcdermott, S, Mcdonald, S, Mcelroy, A, Mcelwee, S, Mcevoy, N, Mckay, C, Mckeown, J, Mclean, K, Mele, F, Menkiti, O, Mentzer, A, Mergler, B, Merson, L, Mesquita, A, Meynert, A, Mihnovit, V, Miller, J, Misnan, N, Mohamed, T, Eliza Mohamed, N, Moin, A, Mone, M, Monteiro, A, Montes, C, Montrucchio, G, Moore, S, Motos, A, Muh, N, Muhamad, D, Murphy, A, Murthy, S, Muyandy, G, Nagpal, D, Nagrebetsky, A, Neto, R, Neumann, E, Ng, W, Choileain, O, Nichol, A, Nitayavardhana, P, Nonas, S, Mohd Noordin, N, Izzati Norharizam, N, Norman, L, Noursadeghi, M, Occhipinti, G, O'Donnell, M, Ogura, T, Oliveira, J, Olliaro, P, Ong, J, Oosthuyzen, W, Openshaw, P, Ortoleva, J, Osatnik, J, Othman, S, Palmarini, M, Panarello, G, Panda, P, Pang, L, Panigada, M, Parke, R, Patauner, F, Pathmanathan, M, Patterson, L, Paulos, J, Paxton, W, Peake, S, Peariasamy, K, Jimenez, M, Pelosi, P, Pereira, R, Periel, L, Pesenti, A, Pimentel, C, Pires, C, Pius, R, Png, H, Poli, S, Pollakis, G, Post, A, Postma, D, Povoa, P, Povoas, D, Preiser, J, Pritchard, M, Proenca, L, Semedi, B, Quesada, L, Quinones-Cardona, V, Gonzalez, V, Quraishi, M, Rafael, A, Rahman, R, Rahman, A, Rajahram, G, Ramalho, J, Ramli, A, Ramos, G, Rangappa, R, Ratsep, I, Rau, C, Ravi, T, Reis, R, Rello, J, Ren, H, Richardson, D, Ahmad Ridzuan, S, Rios, A, Robba, C, Roberto, A, Roberts, S, Robertson, D, Rodeia, S, Roessler, B, Roger, C, Rojek, A, Roncon-Albuquerque, R, Rose, M, Rosenberger, D, Rossetti, M, Russell, C, Ryckaert, S, Saba, I, Sadat, M, Sakiyalak, P, Salazar, L, Sales, G, Sanchez, E, Sancho-Shimizu, V, Sandhu, G, Santos, M, Satyapriya, S, Saviciute, E, Saw, Y, Schaffer, J, Schermer, T, Schwameis, M, Scott, J, Scott-Brown, J, Selvarajoo, M, Semple, M, Senian, R, Sequeira, F, Sequeira, T, Neto, A, Balazote, P, Shahidan, S, Shamsah, M, Sharma, P, Shaw, C, Shaw, V, Shetty, R, Shi, H, Shimizu, H, Shimizu, K, Shrapnel, S, Shum, H, Siang, N, Sigfrid, L, Sillaots, P, Silva, C, Heng, B, Singh, P, Singh, M, Sivam, K, Smith, S, Smood, B, Smyth, C, Snacken, M, Soh, T, Solomon, J, Solomon, T, Somers, E, Song, M, Sousa, M, Uva, M, Sperry, A, Sriskandan, S, Staudinger, T, Stecher, S, Stienstra, Y, Stolz, E, Stuart, A, Stuart, D, Suen, J, Summers, C, Suppiah, D, Syahrin, S, Sztajnbok, J, Szuldrzynski, K, Tabrizi, S, Taccone, F, Taib, S, Taleb, S, Talsma, J, Tan, K, Tan, Y, Tedder, R, Tee, T, Teixeira, J, Tejada, S, Teoh, S, Terpstra, P, Tessier-Grenier, H, Thabit, A, Tham, Z, Thangavelu, S, Thirumanickam, J, Thompson, S, Thomson, D, Thomson, E, Thorpe, M, Thurai, S, Thwaites, R, Toh, J, Tonnii, S, Torre, M, Torres, A, Towers, M, Trapani, T, Turtle, L, Udy, A, Ullrich, R, Uribe, A, Usman, A, Uyeki, T, Val-Flores, L, Van de Velde, S, Van Der Vekens, N, Van der Voort, P, Vanoverschelde, H, Vasudayan, S, Veeran, S, Ventura, S, Vidal, J, Vieira, C, Villanueva, J, Vitiello, C, Wahab, N, Wahab, S, Wahid, N, Wang, C, Webb, S, Wei, J, Wen, T, Wham, M, White, N, Wille, K, Williams, B, Williams, V, Williams, P, Wong, C, Wong, X, Wong, Y, Wong, T, Xian, G, Xian, L, Xuan, K, Mohd Yakop, S, Yamazaki, M, Yarad, E, Hing, N, Yeoh, C, Yerkovich, S, Yokoyama, T, Zaaqoq, A, Zahid, M, Binti Zaidan, N, Zambon, M, Zanella, A, Zaynah, N, Shah N., Xue B., Xu Z., Yang H., Marwali E., Dalton H., Payne P. P. R., Lu C., Said A. S., Abdukahil S. A., Abdulkadir N. N., Absil L., Acker A., Adriao D., Hssain A. A., Akwani C., Qasim E. A., Alalqam R., Al-Dabbous T., Alex B., Al-Fares A., Alfoudri H., Aliudin J., Alves J., Alves R., Alves J. M., Cabrita J. A., Amaral M., Amira N., Andini R., Anthonidass S., Antonelli M., Arabi Y., Arcadipane A., Arenz L., Arnold-Day C., Arora L., Arora R., Ashraf M., Asyraf A., Atique A., Bach B., Baillie J. K., Bak E., Bakar N. A., Balakrishnan M., Barbalho R., Barclay W. S., Barnett S. U., Barnikel M., Barrasa H., Barrigoto C., Baruch J., Hassin Basri M. F., Battaglini D., Bautista Rincon D. F., Bee K. H., Begum H., Beljantsev A., Benjiman L. E., Bento L., Bernal Sobrino J. L., Bertolino L., Bhatt A., Bianco C., Bidin F. N., Humaid F. B., Bin Kamarudin M. N., Blanco-Schweizer P., Bloos F., Boccia F., Bogaert D., Borges D., Bouhmani D., Bouziotis J., Boylan M., Bozza F. A., Brazzi L., Brewster D., Brickell K., Broadley T., Brozzi N., Buchtele N., Burrell A., Cabral S., Cabrita J., Garces R. C., Calligy K., Campbell P., Cardoso S., Cardoso F., Carelli S., Carrier F. M., Carson G., Cascao M., Casimiro J., Castanheira N., Castro I., Catarino A., Cavalin R., Cavalli G. G., Cavayas A., Chand M., Chen A., Chen Y. -S., Cheng M. P., Chica J., Chidambaram S. K., Tho L. C., Cho S. -M., Chow T. S., Chua H. J., Chua J., Cidade J. P., Citarella B. W., Ciullo A., Clarke J., Clohisey S., Codan C., Coles J., Colombo S. M., Connor M., Cooke G. S., Corley A., Cornelis S., Corpuz A. J., Crump J., Cruz C., Cruz Bermudez J. L., Rojo J. C., Csete M., Cullen A., Cummings M., Curley G., Custodio P., Filipe A. S., Dabaliz A. -A., Dagens A., Dahly D., Dalton J., Damas J., Dankwa E. A., Dantas J., de Loughry G., de Rosa R., de Silva T., Deacon J., Dean D., Debenedictis B., Dell'Amore A., Denis E., Depuydt P., Desai M., Dhangar P., Diaz R., Dieperink W., Docherty A. B., Doherty H., Donnelly C. A., Donohue C., Downer T., Drake T., Duculan T., Dunning J., Duplaix M., Durante-Mangoni E., Durham L., Ean S. C., Echeverria-Villalobos M., Elotmani L., Elshazly T., Eng C. C., Escher M., Santo C. E., Estevao J., Everding A. G., Fairfield C. J., Faria P., Fateena H., Fayed M., Fernandes J., Fernandes M. A., Fernandes S., Ferrao J., Ferraz M., Ferreira B., Figueiredo-Mello C., Fiorda J., Fletcher T., Florio L. L., Fonseca T., Forsyth S., Foti G., Fowler R. A., Fraser J. F., Fraser C., Ribeiro A. F., French C., Fukuda M., G A., Gagliardi M., Gaiao S., Gamble C., Gani Y., Garcia R., Barrio N. G., Gavin A., Germano N., Giani M., Gilroy E., Girvan M., Gnall E., Goffard J. -C., Goh J. Y., Golob J., Gonzalez A., Graf J., Grasselli G., Green C. A., Greenhalf W., Grieco D. L., Griffee M., Griffiths F., Lordemann A. G., Gruner H., Gu Y., Guerreiro D., Castro M. G., Hakak S., Hall M., Halpin S., Hamer A., Hammond T., Hammond N., Han L. Y., Hao K. W., Hardwick H., Ekow Harrison S. B., Harrison E. M., Harrison J., Heerman J., Hendry R., Hennessy M., Higgins D., Higgins R., Hinton S., Ho Y. B., Ho A., Hoh W. H., Holt R., Horby P., Hsu J. M. -Y., Hurd A., Ijaz S., Inacio H., Ing Y. S., Isgett S., Isidoro T., Ismail N., Ivulich D., Jackson C., Jelani A. M., Joe O. Y., Joshi S., Jung A., Kaisbain N., Kaleesvran T., Ayadi Kamaluddin M. A., Che Kamaruddin Z. A., Kamarudin N., Kang K. Y., Karpayah P., Kartsonaki C., Kay C., Keating S., Kelly A., Kelly S., Kennon K., Khalid I., Khan I., Kho M. E., Khoo R., Khoo D., Khoo S., Kiat K. H., Kida Y., Kim J. B., Kitamura N., Klenerman P., Knight S. R., Kobbe R., Krishnan V., Kumar D., Kumar G., Kurtzman E., Lalueza A., Lanza M., Law A., Lee T. C., Lee H. G., Lee B. H., Lee Y. L., Lee J., Leeming G., Lene H. S., Leone M., Bassi G. L., Lim K. C., Lim W. S., Lina L., Liu K., Loforte A., Loon L. C., Lopes D., Low L. L., Loy J. S., Bermejo C. L., Lunn M., Lyons R., Maasikas O., Machado S., de la Calle G. M., Maier L. S., Malfertheiner M., Malik N., Sant'ana Malaque C. M., Marino D., Marques A., Marsh B., Marsh L., Marshall J., Martin E., Martinez F. E., Martin-Loeches I., Martins J., Martins A., Rego C. M., Martucci G., Marzukie M., Maynar J., McArthur C., McCanny P., McCloskey C., McDermott S., McDonald S. E., McElroy A., McElwee S., McEvoy N., McKay C., McKeown J., McLean K. A., Mele F., Menkiti O., Mentzer A. J., Mergler B., Merson L., Mesquita A., Meynert A. M., Mihnovit V., Miller J., Misnan N. A., Mohamed T. J., Eliza Mohamed N. N., Moin A., Mone M., Monteiro A., Montes C., Montrucchio G., Moore S. C., Moore S., Motos A., Muh N. Y., Muhamad D., Murphy A., Murthy S., Muyandy G., Nagpal D., Nagrebetsky A., Neto R., Neumann E., Ng W. Y., Choileain O. N., Nichol A. D., Nitayavardhana P., Nonas S., Mohd Noordin N. A., Izzati Norharizam N. F., Norman L., Noursadeghi M., Occhipinti G., O'Donnell M., Ogura T., Oliveira J., Olliaro P. L., Ong J. Y., Oosthuyzen W., Openshaw P., Ortoleva J., Osatnik J., Othman S. Z., Palmarini M., Panarello G., Panda P. K., Pang L. H., Panigada M., Parke R., Patauner F., Pathmanathan M. D., Patterson L., Paulos J., Paxton W. A., Peake S. L., Peariasamy K., Jimenez M. P., Pelosi P., Pereira R., Periel L., Pesenti A., Pimentel C., Pires C., Pius R., Png H. S., Poli S., Pollakis G., Post A. -M., Postma D. F., Povoa P., Povoas D., Preiser J. -C., Pritchard M. G., Proenca L., Semedi B. P., Quesada L., Quinones-Cardona V., Gonzalez V. Q., Quraishi M., Rafael A., Rahman R. A., Rahman A. K. H. A., Rajahram G. S., Ramalho J., Ramli A. A., Ramos G. V., Rangappa R., Ratsep I., Rau C., Ravi T., Reis R., Rello J., Ren H., Richardson D., Ahmad Ridzuan S. N. A., Rios A. L., Robba C., Roberto A., Roberts S., Robertson D. L., Rodeia S., Roessler B., Roger C., Rojek A., Roncon-Albuquerque R., Rose M., Rosenberger D., Rossetti M., Russell C. D., Ryckaert S., Saba I., Sadat M., Sakiyalak P., Salazar L., Sales G., Sanchez E., Sancho-Shimizu V., Sandhu G., Santos M., Satyapriya S., Saviciute E., Saw Y. T., Schaffer J., Schermer T., Schwameis M., Scott J. T., Scott-Brown J., Selvarajoo M., Semple M. G., Senian R. B., Sequeira F., Sequeira T., Neto A. S., Balazote P. S., Shahidan S. A., Shamsah M., Sharma P., Shaw C. A., Shaw V., Shetty R. M., Shi H., Shimizu H., Shimizu K., Shrapnel S., Shum H. P., Siang N. Y., Sigfrid L., Sillaots P., Silva C., Heng B. S. L., Singh P., Singh M., Sivam K., Smith S., Smood B., Smyth C., Snacken M., Soh T. V., Solomon J., Solomon T., Somers E., Song M. J., Sousa M., Uva M. S., Sperry A., Sriskandan S., Staudinger T., Stecher S. -S., Stienstra Y., Stolz E., Stuart A., Stuart D., Suen J. Y., Summers C., Suppiah D., Syahrin S., Sztajnbok J., Szuldrzynski K., Tabrizi S., Taccone F. S., Taib S. M., Taleb S., Talsma J., Tan K. K., Tan Y. C., Tedder R. S., Tee T. Y., Teixeira J., Tejada S., Teoh S. K., Terpstra P., Tessier-Grenier H., Thabit A. A. M., Tham Z. D., Thangavelu S., Thirumanickam J., Thompson S., Thomson D., Thomson E. C., Thorpe M., Thurai S. R. T., Thwaites R. S., Toh J. Z. Y., Tonnii S. L., Torre M., Torres A., Towers M., Trapani T., Turtle L. C. W., Udy A., Ullrich R., Uribe A., Usman A., Uyeki T. M., Val-Flores L., Van de Velde S., Van Der Vekens N., Van der Voort P., Vanoverschelde H., Vasudayan S. R., Veeran S., Ventura S., Vidal J. E., Vieira C., Villanueva J. A., Vitiello C., Wahab N. H., Wahab S. A., Wahid N. A., Wang C. -H., Webb S., Wei J., Wen T. P., Wham M., White N., Wille K., Williams B., Williams V., Williams P. J., Wong C., Wong X. C., Wong Y. S., Wong T. F., Xian G. E., Xian L. S., Xuan K. P., Mohd Yakop S. R. B., Yamazaki M., Yarad E., Hing N. Y. L., Yeoh C. H., Yerkovich S., Yokoyama T., Zaaqoq A., Zahid M., Binti Zaidan N. Z., Zambon M., Zanella A., Zaynah N., Shah, N, Xue, B, Xu, Z, Yang, H, Marwali, E, Dalton, H, Payne, P, Lu, C, Said, A, Abdukahil, S, Abdulkadir, N, Absil, L, Acker, A, Adriao, D, Hssain, A, Akwani, C, Qasim, E, Alalqam, R, Al-Dabbous, T, Alex, B, Al-Fares, A, Alfoudri, H, Aliudin, J, Alves, J, Alves, R, Cabrita, J, Amaral, M, Amira, N, Andini, R, Anthonidass, S, Antonelli, M, Arabi, Y, Arcadipane, A, Arenz, L, Arnold-Day, C, Arora, L, Arora, R, Ashraf, M, Asyraf, A, Atique, A, Bach, B, Baillie, J, Bak, E, Bakar, N, Balakrishnan, M, Barbalho, R, Barclay, W, Barnett, S, Barnikel, M, Barrasa, H, Barrigoto, C, Baruch, J, Hassin Basri, M, Battaglini, D, Bautista Rincon, D, Bee, K, Begum, H, Beljantsev, A, Benjiman, L, Bento, L, Bernal Sobrino, J, Bertolino, L, Bhatt, A, Bianco, C, Bidin, F, Humaid, F, Bin Kamarudin, M, Blanco-Schweizer, P, Bloos, F, Boccia, F, Bogaert, D, Borges, D, Bouhmani, D, Bouziotis, J, Boylan, M, Bozza, F, Brazzi, L, Brewster, D, Brickell, K, Broadley, T, Brozzi, N, Buchtele, N, Burrell, A, Cabral, S, Garces, R, Calligy, K, Campbell, P, Cardoso, S, Cardoso, F, Carelli, S, Carrier, F, Carson, G, Cascao, M, Casimiro, J, Castanheira, N, Castro, I, Catarino, A, Cavalin, R, Cavalli, G, Cavayas, A, Chand, M, Chen, A, Chen, Y, Cheng, M, Chica, J, Chidambaram, S, Tho, L, Cho, S, Chow, T, Chua, H, Chua, J, Cidade, J, Citarella, B, Ciullo, A, Clarke, J, Clohisey, S, Codan, C, Coles, J, Colombo, S, Connor, M, Cooke, G, Corley, A, Cornelis, S, Corpuz, A, Crump, J, Cruz, C, Cruz Bermudez, J, Rojo, J, Csete, M, Cullen, A, Cummings, M, Curley, G, Custodio, P, Filipe, A, Dabaliz, A, Dagens, A, Dahly, D, Dalton, J, Damas, J, Dankwa, E, Dantas, J, de Loughry, G, de Rosa, R, de Silva, T, Deacon, J, Dean, D, Debenedictis, B, Dell'Amore, A, Denis, E, Depuydt, P, Desai, M, Dhangar, P, Diaz, R, Dieperink, W, Docherty, A, Doherty, H, Donnelly, C, Donohue, C, Downer, T, Drake, T, Duculan, T, Dunning, J, Duplaix, M, Durante-Mangoni, E, Durham, L, Ean, S, Echeverria-Villalobos, M, Elotmani, L, Elshazly, T, Eng, C, Escher, M, Santo, C, Estevao, J, Everding, A, Fairfield, C, Faria, P, Fateena, H, Fayed, M, Fernandes, J, Fernandes, M, Fernandes, S, Ferrao, J, Ferraz, M, Ferreira, B, Figueiredo-Mello, C, Fiorda, J, Fletcher, T, Florio, L, Fonseca, T, Forsyth, S, Foti, G, Fowler, R, Fraser, J, Fraser, C, Ribeiro, A, French, C, Fukuda, M, G, A, Gagliardi, M, Gaiao, S, Gamble, C, Gani, Y, Garcia, R, Barrio, N, Gavin, A, Germano, N, Giani, M, Gilroy, E, Girvan, M, Gnall, E, Goffard, J, Goh, J, Golob, J, Gonzalez, A, Graf, J, Grasselli, G, Green, C, Greenhalf, W, Grieco, D, Griffee, M, Griffiths, F, Lordemann, A, Gruner, H, Gu, Y, Guerreiro, D, Castro, M, Hakak, S, Hall, M, Halpin, S, Hamer, A, Hammond, T, Hammond, N, Han, L, Hao, K, Hardwick, H, Ekow Harrison, S, Harrison, E, Harrison, J, Heerman, J, Hendry, R, Hennessy, M, Higgins, D, Higgins, R, Hinton, S, Ho, Y, Ho, A, Hoh, W, Holt, R, Horby, P, Hsu, J, Hurd, A, Ijaz, S, Inacio, H, Ing, Y, 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B., Yamazaki M., Yarad E., Hing N. Y. L., Yeoh C. H., Yerkovich S., Yokoyama T., Zaaqoq A., Zahid M., Binti Zaidan N. Z., Zambon M., Zanella A., and Zaynah N.
- Abstract
Background: Veno-venous extracorporeal membrane oxygenation (V-V ECMO) is a lifesaving support modality for severe respiratory failure, but its resource-intensive nature led to significant controversy surrounding its use during the COVID-19 pandemic. We report the performance of several ECMO mortality prediction and severity of illness scores at discriminating survival in a large COVID-19 V-V ECMO cohort. Methods: We validated ECMOnet, PRESET (PREdiction of Survival on ECMO Therapy-Score), Roch, SOFA (Sequential Organ Failure Assessment), APACHE II (acute physiology and chronic health evaluation), 4C (Coronavirus Clinical Characterisation Consortium), and CURB-65 (Confusion, Urea nitrogen, Respiratory Rate, Blood Pressure, age >65 years) scores on the ISARIC (International Severe Acute Respiratory and emerging Infection Consortium) database. We report discrimination via Area Under the Receiver Operative Curve (AUROC) and Area under the Precision Recall Curve (AURPC) and calibration via Brier score. Results: We included 1147 patients and scores were calculated on patients with sufficient variables. ECMO mortality scores had AUROC (0.58–0.62), AUPRC (0.62–0.74), and Brier score (0.286–0.303). Roch score had the highest accuracy (AUROC 0.62), precision (AUPRC 0.74) yet worst calibration (Brier score of 0.3) despite being calculated on the fewest patients (144). Severity of illness scores had AUROC (0.52–0.57), AURPC (0.59–0.64), and Brier Score (0.265–0.471). APACHE II had the highest accuracy (AUROC 0.58), precision (AUPRC 0.64), and best calibration (Brier score 0.26). Conclusion: Within a large international multicenter COVID-19 cohort, the evaluated ECMO mortality prediction and severity of illness scores demonstrated inconsistent discrimination and calibration highlighting the need for better clinically applicable decision support tools.
- Published
- 2023
3. Thrombotic and hemorrhagic complications of COVID-19 in adults hospitalized in high-income countries compared with those in adults hospitalized in low- and middle-income countries in an international registry
- Author
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R., Saba I., Sadat M., Sahraei V., Saint-Gilles M., Sakiyalak P., Salazar L., Sales G., Sallaberry S., Gandonniere C. S., Salvator H., Sanchez O., Sanchez E., Sanchez-Miralles A., Sancho-Shimizu V., Sandhu G., Sandhu Z., Sandrine P. -F., Sandulescu O., Santos M., Sarfo-Mensah S., Sarmento Banheiro B., Sarmiento I. C. E., Sarton B., Satyapriya S., Satyawati R., Saviciute E., Savvidou P., Saw Y. T., Schaffer J., Schermer T., Scherpereel A., Schneider M., Schroll S., Schwameis M., Scicluna B., Scott J. T., Scott-Brown J., Sedillot N., Seitz T., Selvarajoo M., Semaille C., Semple M. G., Senian R. B., Senneville E., Sepulveda C., Sequeira F., Sequeira T., Neto A. S., Balazote P. S., Shadowitz E., Shahidan S. A., Shamsah M., Sharjeel S., Sharma P., Shaw C. A., Shaw V., Sheenan J. R., Shi H., Shime N., Shimizu K., Shrapnel S., Shum H. P., Mohammed N. S., Siang N. Y., Sibiude J., Siddiqui A., Sigfrid L., Sillaots P., Silva C., Silva R., Silva M. J., Lim Heng B. S., Sin W. C., Singh P., Singh B. C., Sitompul P. A., Sivam K., Skogen V., Smith S., Smood B., Smyth C., Smyth M., Snacken M., So D., Soh T. V., Solomon J., Solomon T., Somers E., Sommet A., Song R., Song M. J., Song T., Chia J. S., Sonntagbauer M., Soom A. M., Sotto A., Soum E., Sousa M., Sousa A. C., Uva M. S., Souza-Dantas V., Sperry A., Spinuzza E., Sriskandan S., Stabler S., Staudinger T., Stecher S. -S., Steinsvik T., Stienstra Y., Stiksrud B., Stolz E., Stone A., Streinu-Cercel A., Stuart A., Stuart D., Su R., Suen J. Y., Suen G., Sukumar P., Sultana A., Summers C., Supic D., Suppiah D., Surovcova M., Syahrin S., Syrigos K., Sztajnbok J., Szuldrzynski K., Tabrizi S., Taccone F. S., Tagherset L., Taib S. M., Taleb S., Talsma J., Tampubolon M. L., Tan K. K., Tan Y. C., Tanaka H., Tanaka T., Taniguchi H., Tardivon C., Tattevin P., Taufik M. A., Tawfik H., Tedder R. S., Tee T. Y., Teixeira J., Tejada S., Tellier M. -C., Teoh S. 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M., Vajdovics C., Val-Flores L., Valran A., Van de Velde S., van den Berge M., Van der Feltz M., van der Palen J., van der Valk P., Van Der Vekens N., Van der Voort P., Van Der Werf S., van Gulik L., Van Hattem J., van Netten C., van Someren Greve F., van Veen I., Van Willigen H., Vanel N., Vanoverschelde H., Varghese P., Varrone M., Vasudayan S. R., Vauchy C., Veeran S., Veislinger A., Vencken S., Ventura S., Verbon A., Vidal J. E., Vieira C., Villanueva J. A., Villar J., Villeneuve P. -M., Villoldo A., Visseaux B., Visser H., Vitiello C., Vonkeman H., Vuotto F., Wahab N. H., Wahab S. A., Wahid N. A., Wainstein M., Walsh L., Wang C. -H., Webb S., Wei J., Weil K., Wen T. P., Wesselius S., Wham M., Whelan B., White N., Wicky P. H., Wiedemann A., Wijaya S. O., Wille K., Willems S., Williams B., Williams V., Williams P. J., Wils E. -J., Wittman J., Wong C., Wong X. C., Wong Y. S., Wong T. F., Xian G. E., Xian L. S., Kuan P. X., Xynogalas I., Binti Mohd Yakop S. R., Yamazaki M., Yarad E., Yazdanpanah Y., Liang Hing N. Y., Yelnik C., Yeoh C. H., Yerkovich S., Yokoyama T., Yonis H., Yousif O., Zaaqoq A., Zabbe M., Zacharowski K., Zahid M., Zahran M., Binti Zaidan N. Z., Zambon M., Zambrano M., Zanella A., Zaynah N., Zayyad H., Zoufaly A., and Zucman D.
- Abstract
Background: COVID-19 has been associated with a broad range of thromboembolic, ischemic, and hemorrhagic complications (coagulopathy complications). Most studies have focused on patients with severe disease from high-income countries (HICs). Objectives: The main aims were to compare the frequency of coagulopathy complications in developing countries (low- and middle-income countries [LMICs]) with those in HICs, delineate the frequency across a range of treatment levels, and determine associations with in-hospital mortality. Methods: Adult patients enrolled in an observational, multinational registry, the International Severe Acute Respiratory and Emerging Infections COVID-19 study, between January 1, 2020, and September 15, 2021, met inclusion criteria, including admission to a hospital for laboratory-confirmed, acute COVID-19 and data on complications and survival. The advanced-treatment cohort received care, such as admission to the intensive care unit, mechanical ventilation, or inotropes or vasopressors; the basic-treatment cohort did not receive any of these interventions. Results: The study population included 495,682 patients from 52 countries, with 63% from LMICs and 85% in the basic treatment cohort. The frequency of coagulopathy complications was higher in HICs (0.76%-3.4%) than in LMICs (0.09%-1.22%). Complications were more frequent in the advanced-treatment cohort than in the basic-treatment cohort. Coagulopathy complications were associated with increased in-hospital mortality (odds ratio, 1.58; 95% CI, 1.52-1.64). The increased mortality associated with these complications was higher in LMICs (58.5%) than in HICs (35.4%). After controlling for coagulopathy complications, treatment intensity, and multiple other factors, the mortality was higher among patients in LMICs than among patients in HICs (odds ratio, 1.45; 95% CI, 1.39-1.51). Conclusion: In a large, international registry of patients hospitalized for COVID-19, coagulopathy complications were mo
- Published
- 2023
4. Association of Country Income Level With the Characteristics and Outcomes of Critically Ill Patients Hospitalized With Acute Kidney Injury and COVID-19
- Author
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H., Yerkovich S., Yokoyama T., Yonis H., Yousif O., Zaaqoq A., Zabbe M., Zahid M., Zahran M., Binti Zaidan N. Z., Zambon M., Zambrano M., Zanella A., Zaynah N., Zayyad H., Zoufaly A., and Zucman D.
- Abstract
Introduction: Acute kidney injury (AKI) has been identified as one of the most common and significant problems in hospitalized patients with COVID-19. However, studies examining the relationship between COVID-19 and AKI in low- and low-middle income countries (LLMIC) are lacking. Given that AKI is known to carry a higher mortality rate in these countries, it is important to understand differences in this population. Methods: This prospective, observational study examines the AKI incidence and characteristics of 32,210 patients with COVID-19 from 49 countries across all income levels who were admitted to an intensive care unit during their hospital stay. Results: Among patients with COVID-19 admitted to the intensive care unit, AKI incidence was highest in patients in LLMIC, followed by patients in upper-middle income countries (UMIC) and high-income countries (HIC) (53%, 38%, and 30%, respectively), whereas dialysis rates were lowest among patients with AKI from LLMIC and highest among those from HIC (27% vs. 45%). Patients with AKI in LLMIC had the largest proportion of community-acquired AKI (CA-AKI) and highest rate of in-hospital death (79% vs. 54% in HIC and 66% in UMIC). The association between AKI, being from LLMIC and in-hospital death persisted even after adjusting for disease severity. Conclusions: AKI is a particularly devastating complication of COVID-19 among patients from poorer nations where the gaps in accessibility and quality of healthcare delivery have a major impact on patient outcomes.
- Published
- 2023
5. Seasonal and diel patterns in activity and habitat use by brook trout (Salvelinus fontinalis) in a small Newfoundland lake
- Author
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Cote, D., Tibble, B., Curry, R. A., Peake, S., Adams, B. K., Clarke, K. D., and Perry, R.
- Published
- 2020
- Full Text
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6. Gastrointestinal Dysfunction During Enteral Nutrition Delivery In ICU Patients: Risk Factors, Natural History And Clinical Implications. A Post-Hoc Analysis Of The Target Trial.
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Arunachala Murthy, T., primary, Chapple, L.-A.S., additional, Lange, K., additional, Marathe, C.S., additional, Horowitz, M., additional, Peake, S., additional, and Chapman, M.J., additional
- Published
- 2023
- Full Text
- View/download PDF
7. Long-term (180-day) outcomes in critically ill patients with COVID-19 in the REMAP-CAP randomized clinical trial
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Reynolds, B, Hussain, M, Dunsavage, J, Saiyed, S, Hernandez, E, Goldman, J, Brown, C, Comp, S, Raczek, J, Morris, J, Vargas Jr., J, Weiss, D, Hensley, J, Kochert, E, Wnuk, C, Nemeth, C, Mowery, B, Hutchinson, C, Winters, L, McAdams, D, Walker, G, Minnier, T, Wisniewski, M, Mayak, K, McCreary, E, Bariola, R, Viehman, A, Daley, J, Lopus, A, Schmidhofer, M, Ambrosino, R, Keen, S, Toffalo, S, Stambaugh, M, Trimmer, K, Perri, R, Casali, S, Medva, R, Massar, B, Beyerl, A, Burkey, J, Keeler, S, Lowery, M, Oncea, L, Daugherty, J, Sevilla, C, Woelke, A, Dice, J, Weber, L, Roth, J, Ferringer, C, Beer, D, Fesz, J, Carpio, L, Colin, G, Zinzoni, V, Maquigneau, N, Henri-Lagarrigue, M, Pouplet, C, Reill, L, Distler, M, Maselli, A, Martynoga, R, Trask, K, Butler, A, Attwood, B, Parsons, P, Campbell, B, Smith, A, Page, V, Zhao, X, Oza, D, Abrahamson, G, Sheath, B, Young, P, Young, C, Lesona, E, Navarra, L, Cruz, R, Delaney, K, Aguilar-Dano, A, Gojanovic, M, Rhodes, J, Anderson, T, Morris, S, Nayyar, V, Bowen, D, Kong, J, Joy, J, Fuchs, R, Lambert, B, Tai, C, Thomas, A, Keen, A, Tierney, C, Omer, N, Bacon, G, Tridente, A, Shuker, K, Anders, J, Greer, S, Scott, P, Millington, A, Buchanan, P, Binnie, A, Powell, E, McMillan, A, Luk, T, Aref, N, Denmade, C, Sadera, G, Jacob, R, Hughes, D, Sterba, M, Geng, W, Digby, S, Southern, D, Reddy, H, Hulse, S, Campbell, A, Garton, M, Watkins, C, Smuts, S, Quinn, A, Simpson, B, McMillan, C, Finch, C, Hill, C, Cooper, J, Budd, J, Small, C, O’Leary, R, Collins, E, Holland, A, Alexander, P, Felton, T, Ferguson, S, Sellers, K, Ward, L, Yates, D, Birkinshaw, I, Kell, K, Scott, Z, Pearson, H, Hashmi, M, Hassan, N, Panjwani, A, Umrani, Z, Shaikh, M, Ain, Q, Kanwal, D, Van Bree, S, Bouw-Ruiter, M, Osinga, M, Van Zanten, A, McEldrew, R, Rashan, S, Singh, V, Azergui, N, Bari, S, Beltran, M, Brugman, C, Groeneveld, E, Jafarzadeh, M, Keijzer-Timmers, N, Kester, E, Koelink, M, Kwakkenbos-Craanen, M, Okundaye, C, Parker, L, Peters, S, Post, S, Rietveld, I, Scheepstra-Beukers, I, Schreuder, G, Smit, A, Brillinger, N, Markgraf, R, Eichinger, F, Doran, P, Anjum, A, Best-Lane, J, Barton, F, Miller, L, Richards-Belle, A, Saull, M, Sprinckmoller, S, Wiley, D, Darnell, R, Au, C, Lindstrum, K, Cheng, A, Forbes, A, Heritier, S, Trapani, T, Cuthbertson, B, Manoharan, V, Dondrop, A, Tolppa, T, Ehrmann, S, Hullegie, S, Povoa, P, Beasley, R, Daneman, N, McGloughlin, S, Paterson, D, Venkatesh, B, De Jong, M, Uyeki, T, Baillie, K, Netea, M, Orr, K, Patanwala, A, Tong, S, Cooper, N, Galea, J, Leavis, H, Ogungbenro, K, Patawala, A, Rademaker, E, Youngstein, T, Carrier, M, Fergusson, D, Hunt, B, Kumar, A, Laffan, M, Lother, S, Middeldorp, S, Stanworth, S, De Man, A, Masse, M-H, Abraham, J, Arnold, D, Begin, P, Charlewood, R, Chasse, M, Coyne, M, Daly, J, Gosbell, I, Harvala-Simmonds, H, MacLennan, S, McDyer, J, Menon, D, Pridee, N, Roberts, D, Thomas, H, Tinmouth, A, Triulzi, D, Walsh, T, Wood, E, Calfee, C, O’Kane, C, Shyamsundar, M, Sinha, P, Thompson, T, Young, I, Burrell, A, Ferguson, N, Hodgson, C, Orford, N, Phua, J, Baron, R, Epelman, S, Frankfurter, C, Gommans, F, Kim, E, Leaf, D, Vaduganathan, M, Van Kimmenade, R, Sanil, A, Van Beurden, M, Effelaar, E, Schotsman, J, Boyd, C, Harland, C, Shearer, A, Wren, J, Attanayaka, U, Darshana, S, Ishani, P, Udayanga, I, Higgins, AM, Berry, LR, Lorenzi, E, Murthy, S, McQuilten, Z, Mouncey, PR, Al-Beidh, F, Annane, D, Arabi, YM, Beane, A, Van Bentum-Puijk, W, Bhimani, Z, Bonten, MJM, Bradbury, CA, Brunkhorst, FM, Buzgau, A, Buxton, M, Charles, WN, Cove, M, Detry, MA, Estcourt, LJ, Fagbodun, EO, Fitzgerald, M, Girard, TD, Goligher, EC, Goossens, H, Haniffa, R, Hills, T, Horvat, CM, Huang, DT, Ichihara, N, Lamontagne, F, Marshall, JC, McAuley, DF, McGlothlin, A, McGuinness, SP, McVerry, BJ, Neal, MD, Nichol, AD, Parke, RL, Parker, JC, Parry-Billings, K, Peters, SEC, Reyes, LF, Rowan, KM, Saito, H, Santos, MS, Saunders, CT, Serpa-Neto, A, Seymour, CW, Shankar-Hari, M, Stronach, LM, Turgeon, AF, Turner, AM, Van de Veerdonk, FL, Zarychanski, R, Green, C, Lewis, RJ, Angus, DC, McArthur, CJ, Berry, S, Derde, LPG, Gordon, AC, Webb, SA, Lawler, PR, Comm REMAP-CAP Investigators, Apollo - University of Cambridge Repository, Intensive Care Medicine, Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil (UVSQ Santé), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Hôpital Raymond Poincaré [Garches], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Pittsburgh Foundation, PF, Amgen, Health Research Board, HRB: CTN 2014-012, Horizon 2020 Framework Programme, H2020: 101003589, Translational Breast Cancer Research Consortium, TBCRC, Canadian Institutes of Health Research, IRSC: 158584, Heart and Stroke Foundation of Canada, HSF, National Institute for Health and Care Research, NIHR, European Commission, EC, National Health and Medical Research Council, NHMRC: 1101719, APP194811, CS-2016-16-011, GNT2008447, RP-2015-06-18, Office of Health and Medical Research, OHMR, Health Research Council of New Zealand, HRC: 16/631, Eisai, Ministère des Affaires Sociales et de la Santé: PHRC-20-0147, Université Pierre et Marie Curie, UPMC, NIHR Imperial Biomedical Research Centre, BRC, Minderoo Foundation, Funding/Support : The Platform for European Preparedness Against (Re-) emerging Epidemics (PREPARE) consortium by the European Union, FP7-HEALTH-2013-INNOVATION-1 (#602525), the Rapid European COVID-19 Emergency Research response (RECOVER) consortium by the European Union’s Horizon 2020 research and innovation programme (#101003589), the Australian National Health and Medical Research Council (#APP1101719), the Australian Medical Research Future Fund (#APP2002132), the Health Research Council of New Zealand (#16/631), the Canadian Institutes of Health Research Strategy for Patient-Oriented Research Innovative Clinical Trials Program Grant (#158584) and the Canadian Institute of Health Research COVID-19 Rapid Research Funding (#447335), the UK National Institute for Health Research (NIHR) and the NIHR Imperial Biomedical Research Centre, the Health Research Board of Ireland (CTN 2014-012), the UPMC Learning While Doing Program, the Translational Breast Cancer Research Consortium, the French Ministry of Health (PHRC-20-0147), the Wellcome Trust Innovations Project (215522), the Minderoo Foundation, the EU Programme Emergency Support Instrument, the NHS Blood and Transplant Research and Development Programme, the Translational Breast Cancer Research Consortium, the NSW Office of Health and Medical Research, Amgen, Eisai, and the Pittsburgh Foundation. Dr Higgins is funded by an NHMRC Emerging Leadership Fellowship (GNT2008447). Dr McQuilten is funded by an NHMRC Emerging Leadership Fellowship (APP194811). Dr Gordon is funded by an NIHR Research Professorship (RP-2015-06-18) and Dr Shankar-Hari by an NIHR Clinician Scientist Fellowship (CS-2016-16-011). Dr Turgeon is the Chairholder of the Canada Research Chair in Critical Care Neurology and Trauma. Dr Lawler is supported by a career award from the Heart and Stroke Foundation of Canada., and European Project: 602525,EC:FP7:HEALTH,FP7-HEALTH-2013-INNOVATION-1,PREPARE(2014)
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Adult ,Male ,corticosteroid ,[SDV]Life Sciences [q-bio] ,Critical Illness ,lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4] ,antiplatelet ,Lopinavir ,Adaptive platform trial randomized controlled trial intensive care, pneumonia COVID-19 antiplatelet immunoglobulin antiviral corticosteroid immune modulation anticoagulation ,All institutes and research themes of the Radboud University Medical Center ,Adrenal Cortex Hormones ,Humans ,anticoagulation ,intensive care, pneumonia ,COVID-19 Serotherapy ,Original Investigation ,Medicine(all) ,immune modulation ,Ritonavir ,SARS-CoV-2 ,COVID-19 ,Anticoagulants ,Bayes Theorem ,General Medicine ,Middle Aged ,antiviral ,Receptors, Interleukin-6 ,Adaptive platform trial ,randomized controlled trial ,Female ,Human medicine ,immunoglobulin ,Follow-Up Studies ,Hydroxychloroquine - Abstract
ImportanceThe longer-term effects of therapies for the treatment of critically ill patients with COVID-19 are unknown.ObjectiveTo determine the effect of multiple interventions for critically ill adults with COVID-19 on longer-term outcomes.Design, Setting, and ParticipantsPrespecified secondary analysis of an ongoing adaptive platform trial (REMAP-CAP) testing interventions within multiple therapeutic domains in which 4869 critically ill adult patients with COVID-19 were enrolled between March 9, 2020, and June 22, 2021, from 197 sites in 14 countries. The final 180-day follow-up was completed on March 2, 2022.InterventionsPatients were randomized to receive 1 or more interventions within 6 treatment domains: immune modulators (n = 2274), convalescent plasma (n = 2011), antiplatelet therapy (n = 1557), anticoagulation (n = 1033), antivirals (n = 726), and corticosteroids (n = 401).Main Outcomes and MeasuresThe main outcome was survival through day 180, analyzed using a bayesian piecewise exponential model. A hazard ratio (HR) less than 1 represented improved survival (superiority), while an HR greater than 1 represented worsened survival (harm); futility was represented by a relative improvement less than 20% in outcome, shown by an HR greater than 0.83.ResultsAmong 4869 randomized patients (mean age, 59.3 years; 1537 [32.1%] women), 4107 (84.3%) had known vital status and 2590 (63.1%) were alive at day 180. IL-6 receptor antagonists had a greater than 99.9% probability of improving 6-month survival (adjusted HR, 0.74 [95% credible interval {CrI}, 0.61-0.90]) and antiplatelet agents had a 95% probability of improving 6-month survival (adjusted HR, 0.85 [95% CrI, 0.71-1.03]) compared with the control, while the probability of trial-defined statistical futility (HR >0.83) was high for therapeutic anticoagulation (99.9%; HR, 1.13 [95% CrI, 0.93-1.42]), convalescent plasma (99.2%; HR, 0.99 [95% CrI, 0.86-1.14]), and lopinavir-ritonavir (96.6%; HR, 1.06 [95% CrI, 0.82-1.38]) and the probabilities of harm from hydroxychloroquine (96.9%; HR, 1.51 [95% CrI, 0.98-2.29]) and the combination of lopinavir-ritonavir and hydroxychloroquine (96.8%; HR, 1.61 [95% CrI, 0.97-2.67]) were high. The corticosteroid domain was stopped early prior to reaching a predefined statistical trigger; there was a 57.1% to 61.6% probability of improving 6-month survival across varying hydrocortisone dosing strategies.Conclusions and RelevanceAmong critically ill patients with COVID-19 randomized to receive 1 or more therapeutic interventions, treatment with an IL-6 receptor antagonist had a greater than 99.9% probability of improved 180-day mortality compared with patients randomized to the control, and treatment with an antiplatelet had a 95.0% probability of improved 180-day mortality compared with patients randomized to the control. Overall, when considered with previously reported short-term results, the findings indicate that initial in-hospital treatment effects were consistent for most therapies through 6 months.
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- 2023
8. Energy Goals in the Critically III Adult
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Peake, S. L., Ridley, E., Chapman, M., and Vincent, Jean-Louis, editor
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- 2011
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9. Do adults with Primary Ciliary Dyskinesia (PCD) have a positive experience of home spirometry?
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Peake, S, primary, Jones, A, additional, Jose, R, additional, Shattock, E, additional, and Loebinger, M R, additional
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- 2022
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10. Designing Capacity-Building in E-Learning Expertise: Challenges and Strategies
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Aczel, J. C., Peake, S. R., and Hardy, P.
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This research study looks at how organizations in developing countries perceive the challenge of building capacity in e-learning expertise. Data was collected on six such organizations, and a range of perceived rationales and constraints were identified. The paper hypothesizes a four-part framework to define the e-learning capacity gaps that these circumstances appear to represent: the "instructional design capacity gap", the "production capacity gap", the "tutorial capacity gap" and the "community building gap". The framework is used to re-examine the data to explore the ways in which the organizations' e-learning activities might constitute strategic responses to the hypothesized capacity gaps.
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- 2008
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11. Protocol describing a systematic review and mixed methods consensus process to define the deteriorated ward patient.
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Malycha, J, Andersen, C, Redfern, OC, Peake, S, Subbe, C, Dykes, L, Phillips, A, Ludbrook, G, Young, D, Watkinson, PJ, Flabouris, A, Jones, D, Malycha, J, Andersen, C, Redfern, OC, Peake, S, Subbe, C, Dykes, L, Phillips, A, Ludbrook, G, Young, D, Watkinson, PJ, Flabouris, A, and Jones, D
- Abstract
INTRODUCTION: Most patients admitted to hospital recover with treatments that can be administered on the general ward. A small but important group deteriorate however and require augmented organ support in areas with increased nursing to patient ratios. In observational studies evaluating this cohort, proxy outcomes such as unplanned intensive care unit admission, cardiac arrest and death are used. These outcome measures introduce subjectivity and variability, which in turn hinders the development and accuracy of the increasing numbers of electronic medical record (EMR) linked digital tools designed to predict clinical deterioration. Here, we describe a protocol for developing a new outcome measure using mixed methods to address these limitations. METHODS AND ANALYSIS: We will undertake firstly, a systematic literature review to identify existing generic, syndrome-specific and organ-specific definitions for clinically deteriorated, hospitalised adult patients. Secondly, an international modified Delphi study to generate a short list of candidate definitions. Thirdly, a nominal group technique (NGT) (using a trained facilitator) will take a diverse group of stakeholders through a structured process to generate a consensus definition. The NGT process will be informed by the data generated from the first two stages. The definition(s) for the deteriorated ward patient will be readily extractable from the EMR. ETHICS AND DISSEMINATION: This study has ethics approval (reference 16399) from the Central Adelaide Local Health Network Human Research Ethics Committee. Results generated from this study will be disseminated through publication and presentation at national and international scientific meetings.
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- 2022
12. A systematic review and meta-analysis of early goal-directed therapy for septic shock: the ARISE, ProCESS and ProMISe Investigators
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Angus, D. C., Barnato, A. E., Bell, D., Bellomo, R., Chong, C.-R., Coats, T. J., Davies, A., Delaney, A., Harrison, D. A., Holdgate, A., Howe, B., Huang, D. T., Iwashyna, T., Kellum, J. A., Peake, S. L., Pike, F., Reade, M. C., Rowan, K. M., Singer, M., Webb, S. A. R., Weissfeld, L. A., Yealy, D. M., and Young, J. D.
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- 2015
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13. Potential Impact of the 2016 Consensus Definitions of Sepsis and Septic Shock on Future Sepsis Research
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Peake, Sandra L., Delaney, Anthony, Bailey, Michael, Bellomo, Rinaldo, Bennett, V., Board, J., McCracken, P., McGloughlin, S., Nanjayya, V., Teo, A., Hill, E., Jones, P., O’Brien, E., Sawtell, F., Schimanski, K., Wilson, D., Bellomo, R., Bolch, S., Eastwood, G., Kerr, F., Peak, L., Young, H., Edington, J., Fletcher, J., Smith, J., Ghelani, D., Nand, K., Sara, T., Cross, A., Flemming, D., Grummisch, M., Purdue, A., Fulton, E., Grove, K., Harney, A., Milburn, K., Millar, R., Mitchell, I., Rodgers, H., Scanlon, S., Coles, T., Connor, H., Dennett, J., Van Berkel, A., Barrington-Onslow, S., Henderson, S., Mehrtens, J., Dryburgh, J., Tankel, A., Braitberg, G., O’Bree, B., Shepherd, K., Vij, S., Allsop, S., Haji, D., Haji, K., Vuat, J., Bone, A., Elderkin, T., Orford, N., Ragg, M., Kelly, S., Stewart, D., Woodward, N., Harjola, V.-P., Okkonen, M., Pettilä, V., Sutinen, S., Wilkman, E., Fratzia, J., Halkhoree, J., Treloar, S., Ryan, K., Sandford, T., Walsham, J., Jenkins, C., Williamson, D., Burrows, J., Hawkins, D., Tang, C., Dimakis, A., Holdgate, A., Micallef, S., Parr, M., White, H., Morrison, L., Sosnowski, K., Ramadoss, R., Soar, N., Wood, J., Franks, M., Williams, A., Hogan, C., Song, R., Tilsley, A., Rainsford, D., Wells, R., Dowling, J., Galt, P., Lamac, T., Lightfoot, D., Walker, C., Braid, K., DeVillecourt, T., Tan, H. S., Seppelt, I., Chang, L. F., Cheung, W. S., Fok, S. K., Lam, P. K., Lam, S. M., So, H. M., Yan, W. W., Altea, A., Lancashire, B., Gomersall, C. D., Graham, C. A., Leung, P., Arora, S., Bass, F., Shehabi, Y., Isoardi, J., Isoardi, K., Powrie, D., Lawrence, S., Ankor, A., Chester, L., Davies, M., O’Connor, S., Poole, A., Soulsby, T., Sundararajan, K., Williams, J., Greenslade, J. H., MacIsaac, C., Gorman, K., Jordan, A., Moore, L., Ankers, S., Bird, S., Delaney, A., Fogg, T., Hickson, E., Jewell, T., Kyneur, K., O’Connor, A., Townsend, J., Yarad, E., Brown, S., Chamberlain, J., Cooper, J., Jenkinson, E., McDonald, E., Webb, S., Buhr, H., Coakley, J., Cowell, J., Hutch, D., Gattas, D., Keir, M., Rajbhandari, D., Rees, C., Baker, S., Roberts, B., Farone, E., Holmes, J., Santamaria, J., Winter, C., Finckh, A., Knowles, S., McCabe, J., Nair, P., Reynolds, C., Ahmed, B., Barton, D., Meaney, E., Nichol, A., Harris, R., Shields, L., Thomas, K., Karlsson, S., Kuitunen, A., Kukkurainen, A., Tenhunen, J., Varila, S., Ryan, N., Trethewy, C., Crosdale, J., Smith, J. C., Vellaichamy, M., Furyk, J., Gordon, G., Jones, L., Senthuran, S., Bates, S., Butler, J., French, C., Tippett, A., Kelly, J., Kwans, J., Murphy, M., O’Flynn, D., Kurenda, C., Otto, T., Peake, S., Raniga, V., Williams, P., Ho, H. F., Leung, A., and Wu, H.
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- 2017
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14. P119 Breathing pattern dysfunction in primary ciliary dyskinesia: myth or reality?
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Housley, GM, primary, Peake, S, additional, and Loebinger, M, additional
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- 2021
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15. PTH-041 Large (<4 cm) and giant (≥4 cm) colorectal polyps: comparison of piecemeal resection outcomes
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Tsiamoulos, ZP, Elliott, T, Rameshshanker, R, Suzuki, N, Peake, S, Bourikas, L, and Saunders, BP
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- 2015
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16. PTU-285 Early in-patient management of alcohol-related liver disease: results of a liver care bundle to improve quality of care
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Huang-Doran, I, Mason, C, Mcphail, M, Peake, S, Monahan, K, and Collins, C
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- 2015
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17. OC-047 A multi disciplinary team (mdt) approach for complex benign colo rectal polyps: a tertiary referral centre experience
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Tsiamoulos, Z, Rameshshanker, R, Wawszczak, A, Elliott, T, Beintaris, I, Bourikas, L, Garg, M, Rajendran, A, Spranger, H, Peake, S, Patel, K, Thomas-Gibson, S, Latchford, A, Humphries, A, Warusavitarne, J, Wilson, A, Faiz, O, Kennedy, R, Haycock, A, and Saunders, BP
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- 2015
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18. Clinical care of pregnant and postpartum women with COVID-19: Living recommendations from the National COVID-19 Clinical Evidence Taskforce.
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Burgess P., Morphet J., Nou S., Russo P., Sarson M., Young A., Norris S., Morris-Donovan B., Gurry S., Hudson E., Hurley S., Primmer D., Timms S., Whicker S., Mukherjee S., Booth K., Cameron P., Cooper M., Cheng A., Fowler P., Frydenberg M., McGloughlin S., McPhee E., Mitchell B., O'Donnell C., Parr M., Phillips J., Varndell W., Whyte I., Randall R., Brightwell R., Condon L., Deshpande A., Ehm A., Ferrie M., Muller J., Pullin L., Robinson E., Witt A., Larkins S., Morgan M., Taylor G., Agostino J., Douglas K., Ewald B., Fornasier D., Knight S., Nelson C., Peachey L., Peiris D., Driel M., Walters L., Weaver I., Burr L., Hendel S., Shekar K., Avard B., Cairns K., Glanville A., Gilroy N., Myles P., O'Sullivan R., Robinson O., Sharland C., McCarthy S., Wark P., McGoughlin S., Hodgson C., Ankravs M., Hansen K., Huckson S., Iredell J., Janerka C., Jaspers R., Litton E., Macdonald S., Peake S., Bowen A., McMullan B., Tingay D., Vasilunas N., Anderson L., Best J., Burns P., Erickson S., Fancourt N., Goff Z., Kapuya V., Keyte C., Malyon L., Wurzel D., Agar M., Lindley R., Smallwood N., Callary M., Chapman M., Good P., Jenkin P., Morgan D., Naganathan V., Srikanth V., Tuffin P., Whiting E., William L., Yates P., Barber B., Davies J., Davis J., Gwee A., Leder K., Matthews G., McMahon J., Peel T., Raftery C., Rees M., Roberts J., Seppelt I., Wibrow B., Baker R., Curnow J., Cutts B., Enjeti A., Forbes A., Ho P., Holyoak A., Liley H., McFadyen J., McQuilten Z., Merriman E., Savoia H., Tan C.W., Tran H., Ward C., Williams K., Ballard N., Bendall S., Bhanderi N., Byers L., Craig S., Ellis D., Ewald D., Fairley C., Hoggard B., Cong M.L., Morley P., Nair P., Pearce A., Turner T., Callesen H., Campbell S., Ring J., Wilson A., Henry D., Pearson S., Boyle D., Chidwick K., Chapman W., French C., Pearce C., Snelling T., Bero L., Grundy Q., Lexchin J., Mintzes B., Vogel J.P., Tendal B., Giles M., Whitehead C., Burton W., Chakraborty S., Cheyne S., Downton T., Fraile Navarro D., Gleeson G., Gordon A., Hunt J., Kitschke J., McDonald S., McDonnell N., Middleton P., Millard T., Murano M., Oats J., Tate R., White H., Elliott J., Roach V., Homer C.S.E., McGowan S., Ballenden N., Barrett T.-L., Beavis V., Saunders J.B., Buchanan T., Buchanan-Grey M., Casey D., Cowie M., Doyle J., Gnjidic D., Green S., Greenland R., Griffin K., Groombridge S., Hardy L., Hodak A., Holley A., Jovanovska V., Michaels K., Burgess P., Morphet J., Nou S., Russo P., Sarson M., Young A., Norris S., Morris-Donovan B., Gurry S., Hudson E., Hurley S., Primmer D., Timms S., Whicker S., Mukherjee S., Booth K., Cameron P., Cooper M., Cheng A., Fowler P., Frydenberg M., McGloughlin S., McPhee E., Mitchell B., O'Donnell C., Parr M., Phillips J., Varndell W., Whyte I., Randall R., Brightwell R., Condon L., Deshpande A., Ehm A., Ferrie M., Muller J., Pullin L., Robinson E., Witt A., Larkins S., Morgan M., Taylor G., Agostino J., Douglas K., Ewald B., Fornasier D., Knight S., Nelson C., Peachey L., Peiris D., Driel M., Walters L., Weaver I., Burr L., Hendel S., Shekar K., Avard B., Cairns K., Glanville A., Gilroy N., Myles P., O'Sullivan R., Robinson O., Sharland C., McCarthy S., Wark P., McGoughlin S., Hodgson C., Ankravs M., Hansen K., Huckson S., Iredell J., Janerka C., Jaspers R., Litton E., Macdonald S., Peake S., Bowen A., McMullan B., Tingay D., Vasilunas N., Anderson L., Best J., Burns P., Erickson S., Fancourt N., Goff Z., Kapuya V., Keyte C., Malyon L., Wurzel D., Agar M., Lindley R., Smallwood N., Callary M., Chapman M., Good P., Jenkin P., Morgan D., Naganathan V., Srikanth V., Tuffin P., Whiting E., William L., Yates P., Barber B., Davies J., Davis J., Gwee A., Leder K., Matthews G., McMahon J., Peel T., Raftery C., Rees M., Roberts J., Seppelt I., Wibrow B., Baker R., Curnow J., Cutts B., Enjeti A., Forbes A., Ho P., Holyoak A., Liley H., McFadyen J., McQuilten Z., Merriman E., Savoia H., Tan C.W., Tran H., Ward C., Williams K., Ballard N., Bendall S., Bhanderi N., Byers L., Craig S., Ellis D., Ewald D., Fairley C., Hoggard B., Cong M.L., Morley P., Nair P., Pearce A., Turner T., Callesen H., Campbell S., Ring J., Wilson A., Henry D., Pearson S., Boyle D., Chidwick K., Chapman W., French C., Pearce C., Snelling T., Bero L., Grundy Q., Lexchin J., Mintzes B., Vogel J.P., Tendal B., Giles M., Whitehead C., Burton W., Chakraborty S., Cheyne S., Downton T., Fraile Navarro D., Gleeson G., Gordon A., Hunt J., Kitschke J., McDonald S., McDonnell N., Middleton P., Millard T., Murano M., Oats J., Tate R., White H., Elliott J., Roach V., Homer C.S.E., McGowan S., Ballenden N., Barrett T.-L., Beavis V., Saunders J.B., Buchanan T., Buchanan-Grey M., Casey D., Cowie M., Doyle J., Gnjidic D., Green S., Greenland R., Griffin K., Groombridge S., Hardy L., Hodak A., Holley A., Jovanovska V., and Michaels K.
- Abstract
To date, 18 living recommendations for the clinical care of pregnant and postpartum women with COVID-19 have been issued by the National COVID-19 Clinical Evidence Taskforce. This includes recommendations on mode of birth, delayed umbilical cord clamping, skin-to-skin contact, breastfeeding, rooming-in, antenatal corticosteroids, angiotensin-converting enzyme inhibitors, disease-modifying treatments (including dexamethasone, remdesivir and hydroxychloroquine), venous thromboembolism prophylaxis and advanced respiratory support interventions (prone positioning and extracorporeal membrane oxygenation). Through continuous evidence surveillance, these living recommendations are updated in near real-time to ensure clinicians in Australia have reliable, evidence-based guidelines for clinical decision-making. Please visit https://covid19evidence.net.au/ for the latest recommendation updates.Copyright © 2020 The Authors. Australian and New Zealand Journal of Obstetrics and Gynaecology published by John Wiley & Sons Australia, Ltd on behalf of Royal Australian and New Zealand College of Obstetricians and Gynaecologists
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- 2021
19. The Australasian Resuscitation In Sepsis Evaluation: FLUid or vasopressors In Emergency Department Sepsis, a multicentre observational study (ARISE FLUIDS observational study): Rationale, methods and analysis plan.
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Keijzers G., Macdonald S.P.J., Udy A.A., Arendts G., Bailey M., Bellomo R., Blecher G.E., Burcham J., Delaney A., Coggins A.R., Fatovich D.M., Fraser J.F., Harley A., Jones P., Kinnear F., May K., Peake S., Taylor D.M., Williams J., Williams P., Keijzers G., Macdonald S.P.J., Udy A.A., Arendts G., Bailey M., Bellomo R., Blecher G.E., Burcham J., Delaney A., Coggins A.R., Fatovich D.M., Fraser J.F., Harley A., Jones P., Kinnear F., May K., Peake S., Taylor D.M., Williams J., and Williams P.
- Abstract
Objective: There is uncertainty about the optimal i.v. fluid volume and timing of vasopressor commencement in the resuscitation of patients with sepsis and hypotension. We aim to study current resuscitation practices in EDs in Australia and New Zealand (the Australasian Resuscitation In Sepsis Evaluation: FLUid or vasopressors In Emergency Department Sepsis [ARISE FLUIDS] observational study). Method(s): ARISE FLUIDS is a prospective, multicentre observational study in 71 hospitals in Australia and New Zealand. It will include adult patients presenting to the ED during a 30 day period with suspected sepsis and hypotension (systolic blood pressure <100 mmHg) despite at least 1000 mL fluid resuscitation. We will obtain data on baseline demographics, clinical and laboratory variables, all i.v. fluid given in the first 24 h, vasopressor use, time to antimicrobial administration, admission to intensive care, organ failure and in-hospital mortality. We will specifically describe (i) the volume of fluid administered at the following time points: when meeting eligibility criteria, in the first 6 h, at 24 h and prior to vasopressor commencement and (ii) the frequency and timing of vasopressor use in the first 6 h and at 24 h. Screening logs will provide reliable estimates of the proportion of ED patients meeting eligibility criteria for a subsequent randomised controlled trial. Discussion(s): This multicentre, observational study will provide insight into current haemodynamic resuscitation practices in patients with sepsis and hypotension as well as estimates of practice variation and patient outcomes. The results will inform the design and feasibility of a multicentre phase III trial of early haemodynamic resuscitation in patients presenting to ED with sepsis and hypotension.Copyright © 2019 Australasian College for Emergency Medicine
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- 2021
20. Does diverticular disease protect against sigmoid colon cancer?
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Tsiamoulos, Z. P., Peake, S. T. C., Nickerson, C., Rutter, M. D., and Saunders, B. P.
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- 2014
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21. P402 Is co-trimoxazole prophylaxis necessary for Inflammatory Bowel Disease patients receiving triple immunosuppression?
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Phillips, G, primary, Moore-Gillan, C, additional, Mohamed, Z, additional, Mikin, P, additional, Peake, S, additional, and Hicks, L, additional
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- 2021
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22. P445 Does The Sequence Matter ? Comparative effectiveness of a second line biologic in patients with Ulcerative Colitis: vedolizumab followed by an anti-TNF versus anti-TNF followed by vedolizumab
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Miller, C, primary, Kwok, H, additional, Parisi, I, additional, Harrow, P, additional, McCartney, S, additional, Vega, R, additional, Rahman, F, additional, Seward, E, additional, Mehta, S, additional, Lim, S, additional, Sharma, E, additional, Samaan, M, additional, Bancil, A, additional, Kok, K, additional, Shalabi, A, additional, Johnston, E, additional, Katarey, D, additional, Taherzadeh, N, additional, Murray, C, additional, Sharip, M, additional, Carter, M, additional, Radhakrishnan, S, additional, Peake, S, additional, Khakoo, I, additional, Wahed, M, additional, Povlsen, S, additional, Patel, M, additional, Dubois, P, additional, Finkel, J, additional, Onnie, C, additional, and Bloom, S, additional
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- 2021
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23. P480 Assessing primary response to biologic therapy in Inflammatory Bowel Disease - ‘the when and the how?’
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Moore, A C, primary and Peake, S, additional
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- 2021
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24. P663 Long-term follow up in IBD: 10-year observational study of a UK IBD cohort
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Radhakrishnan, S T, primary, Vasireddy, A, additional, Gallagher, K I, additional, Hicks, L C, additional, Powles, S T, additional, Chong, L, additional, Peake, S T, additional, Orchard, T R, additional, and Williams, H R T, additional
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- 2021
- Full Text
- View/download PDF
25. The Australasian Resuscitation In Sepsis Evaluation: Fluids or vasopressors in emergency department sepsis (ARISE FLUIDS), a multi-centre observational study describing current practice in Australia and New Zealand.
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Tan E., Burcham J., Coggins A.R., Delaney A., Fatovich D.M., Fraser J.F., Harley A., Jones P., Kinnear F.B., May K., Peake S., Williams P., Nguyen K., Foong L.H., Hullick C., McNulty R., Na A., Trethewy C., Lutze L., Zhang M., Cowan T., Middleton P., Avis S., Vidler S., Salter M., Janes S., Harwood T., Oliver M., Jazayeri F., Jones S., Davoren M., Coggins A., Pradhananga B., Newby L., Beck S., Sandleback B., Rabas S., Harger S., Song R., Gutenstein M., Munro A., Connely M., Goodson J., Mclean A., Brabyn C., Mukerji S., Simmonds H., Young P., Sugeng Y., Bird C., McConnell A., Henderson P., Johnson D., Perez S., Mahani A., Orda U., Thom O., Roberts K., Kinnear F., Hazelwood S., Pham H., Eley R., Livesay G., Devlin M., Murdoch I., Wood E., Williams J., Brown N., King A., Sadewasser J., Jones L., Gangathimmaiah V., Manudhane A., Haustead D., Ascencio-Lane J.-C., Taylor D.M., Buntine P., Walker K., Pouryahya P., Crompton D., Sultana R., Campbell T., Dwyer R., Blecher G., Knott J., Mitra B., Luckhoff C., Young R., Rudling N., Mukherjee A., Dyke K.-L., Parker C., Cooper A., Nagree Y., Koay K., Kruger C., Ghedina N., Smedley B., Macdonald S., Hamersley H., Keijzers G., Macdonald S.P.J., Udy A.A., Arendts G., Bailey M., Bellomo R., Blecher G.E., Tan E., Burcham J., Coggins A.R., Delaney A., Fatovich D.M., Fraser J.F., Harley A., Jones P., Kinnear F.B., May K., Peake S., Williams P., Nguyen K., Foong L.H., Hullick C., McNulty R., Na A., Trethewy C., Lutze L., Zhang M., Cowan T., Middleton P., Avis S., Vidler S., Salter M., Janes S., Harwood T., Oliver M., Jazayeri F., Jones S., Davoren M., Coggins A., Pradhananga B., Newby L., Beck S., Sandleback B., Rabas S., Harger S., Song R., Gutenstein M., Munro A., Connely M., Goodson J., Mclean A., Brabyn C., Mukerji S., Simmonds H., Young P., Sugeng Y., Bird C., McConnell A., Henderson P., Johnson D., Perez S., Mahani A., Orda U., Thom O., Roberts K., Kinnear F., Hazelwood S., Pham H., Eley R., Livesay G., Devlin M., Murdoch I., Wood E., Williams J., Brown N., King A., Sadewasser J., Jones L., Gangathimmaiah V., Manudhane A., Haustead D., Ascencio-Lane J.-C., Taylor D.M., Buntine P., Walker K., Pouryahya P., Crompton D., Sultana R., Campbell T., Dwyer R., Blecher G., Knott J., Mitra B., Luckhoff C., Young R., Rudling N., Mukherjee A., Dyke K.-L., Parker C., Cooper A., Nagree Y., Koay K., Kruger C., Ghedina N., Smedley B., Macdonald S., Hamersley H., Keijzers G., Macdonald S.P.J., Udy A.A., Arendts G., Bailey M., Bellomo R., and Blecher G.E.
- Abstract
Objectives: To describe haemodynamic resuscitation practices in ED patients with suspected sepsis and hypotension. Method(s): This was a prospective, multicentre, observational study conducted in 70 hospitals in Australia and New Zealand between September 2018 and January 2019. Consecutive adults presenting to the ED during a 30-day period at each site, with suspected sepsis and hypotension (systolic blood pressure <100 mmHg) despite at least 1000 mL fluid resuscitation, were eligible. Data included baseline demographics, clinical and laboratory variables and intravenous fluid volume administered, vasopressor administration at baseline and 6- and 24-h post-enrolment, time to antimicrobial administration, intensive care admission, organ support and in-hospital mortality. Result(s): A total of 4477 patients were screened and 591 were included with a mean (standard deviation) age of 62 (19) years, Acute Physiology and Chronic Health Evaluation II score 15.2 (6.6) and a median (interquartile range) systolic blood pressure of 94 mmHg (87-100). Median time to first intravenous antimicrobials was 77 min (42-148). A vasopressor infusion was commenced within 24 h in 177 (30.2%) patients, with noradrenaline the most frequently used (n = 138, 78%). A median of 2000 mL (1500-3000) of intravenous fluids was administered prior to commencing vasopressors. The total volume of fluid administered from pre-enrolment to 24 h was 4200 mL (3000-5661), with a range from 1000 to 12 200 mL. Two hundred and eighteen patients (37.1%) were admitted to an intensive care unit. Overall in-hospital mortality was 6.2% (95% confidence interval 4.4-8.5%). Conclusion(s): Current resuscitation practice in patients with sepsis and hypotension varies widely and occupies the spectrum between a restricted volume/earlier vasopressor and liberal fluid/later vasopressor strategy.Copyright © 2020 The Authors. Emergency Medicine Australasia published by John Wiley & Sons Australia, Ltd on behalf of Australasian
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- 2020
26. The Australasian Resuscitation In Sepsis Evaluation: Fluids or vasopressors in emergency department sepsis (ARISE FLUIDS), a multi-centre observational study describing current practice in Australia and New Zealand
- Author
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Keijzers, G, Macdonald, SPJ, Udy, AA, Arendts, G, Bailey, M, Bellomo, R, Blecher, GE, Burcham, J, Coggins, AR, Delaney, A, Fatovich, DM, Fraser, JF, Harley, A, Jones, P, Kinnear, FB, May, K, Peake, S, Taylor, DM, Williams, P, Khanh, N, Foong, LH, Hullick, C, McNulty, R, Na, A, Trethewy, C, Lutze, L, Zhang, M, Cowan, T, Middleton, P, Avis, S, Vidler, S, Salter, M, Janes, S, Harwood, T, Oliver, M, Jazayeri, F, Jones, S, Davoren, M, Coggins, A, Pradhananga, B, Newby, L, Beck, S, Sandleback, B, Rabas, S, Harger, S, Tan, E, Song, R, Gutenstein, M, Munro, A, Connely, M, Goodson, J, Mclean, A, Brabyn, C, Mukerji, S, Simmonds, H, Young, P, Sugeng, Y, Bird, C, McConnell, A, Henderson, P, Johnson, D, Perez, S, Mahani, A, Orda, U, Thom, O, Roberts, K, Kinnear, F, Hazelwood, S, Hanh, P, Eley, R, Livesay, G, Devlin, M, Murdoch, I, Wood, E, Williams, J, Brown, N, King, A, Sadewasser, J, Jones, L, Gangathimmaiah, V, Manudhane, A, Haustead, D, Ascencio-Lane, J-C, Buntine, P, Walker, K, Pouryahya, P, Crompton, D, Sultana, R, Campbell, T, Dwyer, R, Blecher, G, Knott, J, Mitra, B, Luckhoff, C, Young, R, Rudling, N, Mukherjee, A, Dyke, K-L, Parker, C, Cooper, A, Nagree, Y, Koay, K, Kruger, C, Ghedina, N, Smedley, B, Macdonald, S, Hamersley, H, Keijzers, G, Macdonald, SPJ, Udy, AA, Arendts, G, Bailey, M, Bellomo, R, Blecher, GE, Burcham, J, Coggins, AR, Delaney, A, Fatovich, DM, Fraser, JF, Harley, A, Jones, P, Kinnear, FB, May, K, Peake, S, Taylor, DM, Williams, P, Khanh, N, Foong, LH, Hullick, C, McNulty, R, Na, A, Trethewy, C, Lutze, L, Zhang, M, Cowan, T, Middleton, P, Avis, S, Vidler, S, Salter, M, Janes, S, Harwood, T, Oliver, M, Jazayeri, F, Jones, S, Davoren, M, Coggins, A, Pradhananga, B, Newby, L, Beck, S, Sandleback, B, Rabas, S, Harger, S, Tan, E, Song, R, Gutenstein, M, Munro, A, Connely, M, Goodson, J, Mclean, A, Brabyn, C, Mukerji, S, Simmonds, H, Young, P, Sugeng, Y, Bird, C, McConnell, A, Henderson, P, Johnson, D, Perez, S, Mahani, A, Orda, U, Thom, O, Roberts, K, Kinnear, F, Hazelwood, S, Hanh, P, Eley, R, Livesay, G, Devlin, M, Murdoch, I, Wood, E, Williams, J, Brown, N, King, A, Sadewasser, J, Jones, L, Gangathimmaiah, V, Manudhane, A, Haustead, D, Ascencio-Lane, J-C, Buntine, P, Walker, K, Pouryahya, P, Crompton, D, Sultana, R, Campbell, T, Dwyer, R, Blecher, G, Knott, J, Mitra, B, Luckhoff, C, Young, R, Rudling, N, Mukherjee, A, Dyke, K-L, Parker, C, Cooper, A, Nagree, Y, Koay, K, Kruger, C, Ghedina, N, Smedley, B, Macdonald, S, and Hamersley, H
- Abstract
OBJECTIVES: To describe haemodynamic resuscitation practices in ED patients with suspected sepsis and hypotension. METHODS: This was a prospective, multicentre, observational study conducted in 70 hospitals in Australia and New Zealand between September 2018 and January 2019. Consecutive adults presenting to the ED during a 30-day period at each site, with suspected sepsis and hypotension (systolic blood pressure <100 mmHg) despite at least 1000 mL fluid resuscitation, were eligible. Data included baseline demographics, clinical and laboratory variables and intravenous fluid volume administered, vasopressor administration at baseline and 6- and 24-h post-enrolment, time to antimicrobial administration, intensive care admission, organ support and in-hospital mortality. RESULTS: A total of 4477 patients were screened and 591 were included with a mean (standard deviation) age of 62 (19) years, Acute Physiology and Chronic Health Evaluation II score 15.2 (6.6) and a median (interquartile range) systolic blood pressure of 94 mmHg (87-100). Median time to first intravenous antimicrobials was 77 min (42-148). A vasopressor infusion was commenced within 24 h in 177 (30.2%) patients, with noradrenaline the most frequently used (n = 138, 78%). A median of 2000 mL (1500-3000) of intravenous fluids was administered prior to commencing vasopressors. The total volume of fluid administered from pre-enrolment to 24 h was 4200 mL (3000-5661), with a range from 1000 to 12 200 mL. Two hundred and eighteen patients (37.1%) were admitted to an intensive care unit. Overall in-hospital mortality was 6.2% (95% confidence interval 4.4-8.5%). CONCLUSION: Current resuscitation practice in patients with sepsis and hypotension varies widely and occupies the spectrum between a restricted volume/earlier vasopressor and liberal fluid/later vasopressor strategy.
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- 2020
27. Gender differences in mortality and quality of life after septic shock: A post-hoc analysis of the ARISE study
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Luethi, N, Bailey, M, Higgins, A, Howe, B, Peake, S, Delaney, A, Bellomo, R, Bennett, V, Board, J, McCracken, P, McGloughlin, S, Nanjayya, V, Teo, A, Hill, E, O'Brien, PJE, Sawtell, F, Schimanski, K, Wilson, D, Bolch, S, Eastwood, G, Kerr, F, Peak, L, Young, H, Edington, J, Fletcher, J, Smith, J, Ghelani, D, Nand, K, Sara, T, Cross, A, Flemming, D, Grummisch, M, Purdue, A, Fulton, E, Grove, K, Harney, A, Milburn, K, Millar, R, Mitchell, I, Rodgers, H, Scanlon, S, Coles, T, Connor, H, Dennett, J, Van Berkel, A, Barrington-Onslow, S, Henderson, S, Mehrtens, J, Dryburgh, J, Tankel, A, Braitberg, G, O'Bree, B, Shepherd, K, Vij, S, Allsop, S, Haji, D, Haji, K, Vuat, J, Bone, A, Elderkin, T, Orford, N, Ragg, M, Kelly, S, Stewart, D, Woodward, N, Harjola, V-P, Pettila, MO, Sutinen, S, Wilkman, E, Fratzia, J, Halkhoree, J, Treloar, S, Ryan, K, Sandford, T, Walsham, J, Jenkins, C, Williamson, D, Burrows, J, Hawkins, D, Tang, C, Dimakis, A, Holdgate, A, Micallef, S, Parr, M, White, H, Morrison, L, Sosnowski, K, Ramadoss, R, Soar, N, Wood, J, Franks, M, Williams, A, Hogan, C, Song, R, Tilsley, A, Rainsford, D, Wells, R, Dowling, J, Galt, P, Lamac, T, Lightfoot, D, Walker, C, Braid, K, DeVillecourt, T, Tan, HS, Seppelt, I, Chang, LF, Cheung, WS, Fok, SK, Lam, PK, Lam, SM, So, HM, Yan, W, Altea, A, Lancashire, B, Gomersall, CD, Graham, CA, Leung, P, Arora, S, Bass, F, Shehabi, Y, Isoardi, J, Isoardi, K, Powrie, D, Lawrence, S, Ankor, A, Chester, L, Davies, M, O'Connor, S, Poole, A, Soulsby, T, Sundararajan, K, Williams, J, Greenslade, JH, MacIsaac, C, Gorman, K, Jordan, A, Moore, L, Ankers, S, Bird, S, Fogg, T, Hickson, E, Jewell, T, Kyneur, K, O'Connor, A, Townsend, J, Yarad, E, Brown, S, Chamberlain, J, Cooper, J, Jenkinson, E, McDonald, E, Webb, S, Buhr, H, Coakley, J, Cowell, J, Hutch, D, Gattas, D, Keir, M, Rajbhandari, D, Rees, C, Baker, S, Roberts, B, Farone, E, Holmes, J, Santamaria, J, Winter, C, Finckh, A, Knowles, S, McCabe, J, Nair, P, Reynolds, C, Ahmed, B, Barton, D, Meaney, E, Nichol, A, Harris, R, Shields, L, Thomas, K, Karlsson, S, Kuitunen, A, Kukkurainen, A, Tenhunen, J, Varila, S, Ryan, N, Trethewy, C, Crosdale, J, Smith, JC, Vellaichamy, M, Furyk, J, Gordon, G, Jones, L, Senthuran, S, Bates, S, Butler, J, French, C, Tippett, A, Kelly, J, Kwans, J, Murphy, M, O'Flynn, D, Kurenda, C, Otto, T, Raniga, V, Williams, P, Ho, HF, Leung, A, Wu, H, Luethi, N, Bailey, M, Higgins, A, Howe, B, Peake, S, Delaney, A, Bellomo, R, Bennett, V, Board, J, McCracken, P, McGloughlin, S, Nanjayya, V, Teo, A, Hill, E, O'Brien, PJE, Sawtell, F, Schimanski, K, Wilson, D, Bolch, S, Eastwood, G, Kerr, F, Peak, L, Young, H, Edington, J, Fletcher, J, Smith, J, Ghelani, D, Nand, K, Sara, T, Cross, A, Flemming, D, Grummisch, M, Purdue, A, Fulton, E, Grove, K, Harney, A, Milburn, K, Millar, R, Mitchell, I, Rodgers, H, Scanlon, S, Coles, T, Connor, H, Dennett, J, Van Berkel, A, Barrington-Onslow, S, Henderson, S, Mehrtens, J, Dryburgh, J, Tankel, A, Braitberg, G, O'Bree, B, Shepherd, K, Vij, S, Allsop, S, Haji, D, Haji, K, Vuat, J, Bone, A, Elderkin, T, Orford, N, Ragg, M, Kelly, S, Stewart, D, Woodward, N, Harjola, V-P, Pettila, MO, Sutinen, S, Wilkman, E, Fratzia, J, Halkhoree, J, Treloar, S, Ryan, K, Sandford, T, Walsham, J, Jenkins, C, Williamson, D, Burrows, J, Hawkins, D, Tang, C, Dimakis, A, Holdgate, A, Micallef, S, Parr, M, White, H, Morrison, L, Sosnowski, K, Ramadoss, R, Soar, N, Wood, J, Franks, M, Williams, A, Hogan, C, Song, R, Tilsley, A, Rainsford, D, Wells, R, Dowling, J, Galt, P, Lamac, T, Lightfoot, D, Walker, C, Braid, K, DeVillecourt, T, Tan, HS, Seppelt, I, Chang, LF, Cheung, WS, Fok, SK, Lam, PK, Lam, SM, So, HM, Yan, W, Altea, A, Lancashire, B, Gomersall, CD, Graham, CA, Leung, P, Arora, S, Bass, F, Shehabi, Y, Isoardi, J, Isoardi, K, Powrie, D, Lawrence, S, Ankor, A, Chester, L, Davies, M, O'Connor, S, Poole, A, Soulsby, T, Sundararajan, K, Williams, J, Greenslade, JH, MacIsaac, C, Gorman, K, Jordan, A, Moore, L, Ankers, S, Bird, S, Fogg, T, Hickson, E, Jewell, T, Kyneur, K, O'Connor, A, Townsend, J, Yarad, E, Brown, S, Chamberlain, J, Cooper, J, Jenkinson, E, McDonald, E, Webb, S, Buhr, H, Coakley, J, Cowell, J, Hutch, D, Gattas, D, Keir, M, Rajbhandari, D, Rees, C, Baker, S, Roberts, B, Farone, E, Holmes, J, Santamaria, J, Winter, C, Finckh, A, Knowles, S, McCabe, J, Nair, P, Reynolds, C, Ahmed, B, Barton, D, Meaney, E, Nichol, A, Harris, R, Shields, L, Thomas, K, Karlsson, S, Kuitunen, A, Kukkurainen, A, Tenhunen, J, Varila, S, Ryan, N, Trethewy, C, Crosdale, J, Smith, JC, Vellaichamy, M, Furyk, J, Gordon, G, Jones, L, Senthuran, S, Bates, S, Butler, J, French, C, Tippett, A, Kelly, J, Kwans, J, Murphy, M, O'Flynn, D, Kurenda, C, Otto, T, Raniga, V, Williams, P, Ho, HF, Leung, A, and Wu, H
- Abstract
PURPOSE: To assess the impact of gender and pre-menopausal state on short- and long-term outcomes in patients with septic shock. MATERIAL AND METHODS: Cohort study of the Australasian Resuscitation in Sepsis Evaluation (ARISE) trial, an international randomized controlled trial comparing early goal-directed therapy (EGDT) to usual care in patients with early septic shock, conducted between October 2008 and April 2014. The primary exposure in this analysis was legal gender and the secondary exposure was pre-menopausal state defined by chronological age (≤ 50 years). RESULTS: 641 (40.3%) of all 1591 ARISE trial participants in the intention-to-treat population were females and overall, 337 (21.2%) (146 females) patients were 50 years of age or younger. After risk-adjustment, we could not identify any survival benefit for female patients at day 90 in the younger (≤50 years) (adjusted Odds Ratio (aOR): 0.91 (0.46-1.89), p = .85) nor in the older (>50 years) age-group (aOR: 1.10 (0.81-1.49), p = .56). Similarly, there was no gender-difference in ICU, hospital, 1-year mortality nor quality of life measures. CONCLUSIONS: This post-hoc analysis of a large multi-center trial in early septic shock has shown no short- or long-term survival effect for women overall as well as in the pre-menopausal age-group.
- Published
- 2020
28. Acute Didecyl Dimethyl Ammonium Chloride Toxicity to Larval Lake Sturgeon, Acipenser fulvescens Rafinesque, Walleye Sander vitreus Mitchill, and Northern Pike, Esox lucius Linnaeus
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Gray, M. A., Peake, S. J., Farrell, A. P., and Bruch, R.
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- 2005
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29. Lost therapeutic potential of monocyte-derived dendritic cells through lost tissue homing: stable restoration of gut specificity with retinoic acid
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Bernardo, D., Mann, E. R., Al-Hassi, H. O., English, N. R., Man, R., Lee, G. H., Ronde, E., Landy, J., Peake, S. T. C., Hart, A. L., and Knight, S. C.
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- 2013
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30. Commentary: predicting response to ciclosporin in acute severe ulcerative colitis
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Peake, S. T. and Hart, A. L.
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- 2012
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31. Skin- and gut-homing molecules on human circulating γδ T cells and their dysregulation in inflammatory bowel disease
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Mann, E. R., McCarthy, N. E., Peake, S. T. C., Milestone, A. N., Al-Hassi, H. O., Bernardo, D., Tee, C. T., Landy, J., Pitcher, M. C., Cochrane, S. A., Hart, A. L., Stagg, A. J., and Knight, S. C.
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- 2012
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32. Tissue specific, homeostatic properties of human gut dendritic cells: small bowel versus colon: W53.005
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Mann, E., Peake, S. T. C., Bernardo, D., Landy, J., Al-Hassi, H. O., and Knight, S. C.
- Published
- 2012
33. OC-160 Telemedicine systems in IBD management—are patients ready?
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Landy, J, Peake, S T, Akbar, A, and Hart, A L
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- 2012
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34. Seasonal and diel patterns in activity and habitat use by brook trout (Salvelinus fontinalis) in a small Newfoundland lake
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Cote, D., primary, Tibble, B., additional, Curry, R. A., additional, Peake, S., additional, Adams, B. K., additional, Clarke, K. D., additional, and Perry, R., additional
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- 2019
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35. CD32 expressing doublets in HIV-infected gut-associated lymphoid tissue are associated with a T follicular helper cell phenotype
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Thornhill, J, Pace, M, Martin, G, Hoare, J, Peake, S, Herrera, C, Phetsouphanh, C, Meyerowitz, J, Hopkins, E, Brown, H, Dunn, P, Olejniczak, N, Willberg, C, Klenerman, P, Goldin, R, Fox, J, Fidler, S, Frater, J, Investigators, Cherub, MRC DCS, British HIV Association (BHIVA), Merck Sharp & Dohme Ltd., Medical Research Council (MRC), and Medical Research Council
- Subjects
Adult ,Male ,0301 basic medicine ,CD32 ,BLOOD ,Gut-associated lymphoid tissue ,Immunology ,Gene Expression ,HIV Infections ,Biology ,CXCR5 ,Immunophenotyping ,Peyer's Patches ,03 medical and health sciences ,0302 clinical medicine ,Antiretroviral Therapy, Highly Active ,medicine ,Humans ,Immunology and Allergy ,11 Medical and Health Sciences ,Aged ,CHERUB investigators ,B-Lymphocytes ,Science & Technology ,PERSISTENCE ,Receptors, IgG ,DNA ,T-Lymphocytes, Helper-Inducer ,Middle Aged ,Viral Load ,06 Biological Sciences ,Phenotype ,CD4 Lymphocyte Count ,030104 developmental biology ,Lymphatic system ,medicine.anatomical_structure ,Tonsil ,HIV-1 ,biology.protein ,Female ,Life Sciences & Biomedicine ,Viral load ,Biomarkers ,030215 immunology - Abstract
Gut-associated lymphoid tissue (GALT) is a key location for the HIV reservoir. The observation that B-cell–T-cell doublets are enriched for CD32a (a low-affinity IgG receptor) in peripheral blood raises interesting questions, especially as these cells have been associated with HIV DNA in some studies. We sought to determine if similar doublets were present in GALT, the significance of these doublets, and their implications for the HIV reservoir. Given the importance of GALT as a reservoir for HIV, we looked for expression of CD32 on gut CD4 T cells and for evidence of doublets, and any relationship with HIV DNA in HIV + individuals initiated on antiretroviral therapy (ART) during primary HIV infection (PHI). Tonsil tissue was also available for one individual. As previously shown for blood, CD32high CD4 cells were mainly doublets of CD4 T cells and B cells, with T-cell expression of ICOS in tonsil and gut tissue. CD4 T cells associated with CD32 (compared with ‘CD32−' CD4 cells) had higher expression of follicular markers CXCR5, PD-1, ICOS, and Bcl-6 consistent with a T follicular helper (TFH) phenotype. There was a significant correlation between rectal HIV DNA levels and CD32 expression on TFH cells. Together, these data suggest that CD32high doublets are primarily composed of TFH cells, a subset known to be preferentially infected by HIV.
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- 2019
36. The impact of vorinostat and therapeutic vaccine on gut HIV DNA: the RIVER gut study
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Thornhill, J, Herrera, C, Hoare, J, Peake, S, Brown, H, Nwokolo, N, Fox, J, Hanke, T, Frater, J, and Fidler, S
- Published
- 2019
37. Free Papers
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Emmanuel, G., Carranza, S., Vettichira, S., Paradis, M., Lie, T., Kessler, P., Schini-Kerth, V. B., Koh, Y., Hybertson, B. M., Jepson, E. K., Kim, M. J., Lee, I., Lim, C. M., Lee, S. D., Kim, W. S., Kim, D. S., Kim, W. D., Repine, J. E., Takeda, T., Yukioka, T., Matsuda, H., Shimazaki, S., Kammermeier, D., Birkmann, J., Blinzler, L., Gallmeier, W. M., Heuser, D., Jourdain, M., Mangalaboyi, J., Carrette, O., Toumoys, A., Fourrier, F., Mizon, J., Chopin, C., Peake, S. L., Carter, J. K., Russ, R. G., Pierides, J., Leppard, J. P., Porter, K., Galley, H. F., Webster, N. R., Wigmore, S. J., Walsh, T. S., Hopton, P., Lee, A., Ross, J. A., Majcherczyk, P. A., Pugin, J., Glauser, M. P., Heumann, D., Zanetti, G., de Werra, I., Sablotzki, A., Welters, I., Menges, T., Görlach, G., Lehmann, N., Hempelmann, G., Giannitsis, E., Tettenborn, I., Stierle, U., Dalhoff, K., Sheikhzadeh, A., Diederich, K. W., Gant, V., Maciver, C., Treacher, D. F., Lamy, M., Thijs, L. G., Eisele, B., Keinecke, H. -O., Schuster, H. P., Matthias, F. R., Oettinger, W., Hartenauer, U., Fourrier, F., Delvos, U., Stott, S. A., Noble, D. W., Schobersberger, W., Hoffmann, G., Fandrey, J., Bellingan, G. J., Caldwell, H., Dransfield, I., Howie, S. M., Haslett, C., Liaudet, L., Feihl, F., Markert, M., Perret, C., Williams, M. A., Rhoades, C., White, S. A., Miller, J., Withington, S., Newland, A. C., Kelsey, S. M., Froon, A., Bonten, M., Gaillard, C., Greve, J., de Leeuw, P., Drent, M., Stobberingh, E., Buurman, W., Fourcade, O., Simon, M. -F., Leballe, F., Ashraf, R., Sarda, L., Cathala, B., Chap, H., Reper, P., Danckaert, R., Jeunen, R., Bruyns, T., De Hemptinne, J., and Vanderkelen, A.
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- 1996
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38. Evolution not revolution: the future of the randomised controlled trial in intensive care research
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Peake, S, Delaney, A, French, CJ, Peake, S, Delaney, A, and French, CJ
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- 2019
39. Initiation of vasopressor infusions via peripheral versus central access in patients with early septic shock: A retrospective cohort study
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Delaney, A, Finnis, M, Bellomo, R, Udy, A, Jones, D, Keijzers, G, Macdonald, S, Peake, S, Delaney, A, Finnis, M, Bellomo, R, Udy, A, Jones, D, Keijzers, G, Macdonald, S, and Peake, S
- Abstract
OBJECTIVE: To assess whether the initiation of vasopressor infusions via peripheral venous catheters (PVC) compared to central venous catheters (CVC) in ED patients with early septic shock was associated with differences in processes of care and outcomes. METHODS: We conducted a post-hoc analysis of the ARISE trial. We compared participants who had a vasopressor infusion first commenced via a PVC versus a CVC. The primary outcome was 90 day mortality. RESULTS: We studied 937 participants. Of these, 389 (42%) had early vasopressor infusion commenced via a PVC and 548 (58%) via a CVC. Trial participants who received a vasopressor infusion via a PVC were more severely ill, with higher median (interquartile range [IQR]) Acute Physiology And Chronic Health Evaluation (APACHE II) scores (17 [13-23] versus 16 [12-21], P = 0.003), and higher median (IQR) lactate (mmol/L) (3.6 [1.9-5.8] versus 2.5 [1.5-4.5], P < 0.001). After adjusting for baseline covariates, the estimated odds ratio for mortality for PVC-treated patients was 1.26 (95% confidence interval 0.95-1.67, P = 0.11). Trial participants who had vasopressors commenced via PVC had a shorter median (IQR) time to commencement of antimicrobials (55 [32-96] versus 71.5 [39-119] min, P < 0.001) and a shorter median (IQR) time to commencement of vasopressors (2.4 [1.3-3.9] versus 4.9 [3.5-6.6] h, P < 0.001). CONCLUSION: The practice of commencing a vasopressor infusion via a PVC was common in the ARISE trial and more frequent in trial participants with higher severity of illness. Commencement of a vasopressor infusion via a PVC was associated with some improvements in processes of care and, after adjustment, was not associated with an increased risk of death.
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- 2019
40. The Australasian Resuscitation In Sepsis Evaluation: FLUid or vasopressors In Emergency Department Sepsis, a multicentre observational study (ARISE FLUIDS observational study): Rationale, methods and analysis plan
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Keijzers, G, Macdonald, SPJ, Udy, AA, Arendts, G, Bailey, M, Bellomo, R, Blecher, GE, Burcham, J, Delaney, A, Coggins, AR, Fatovich, DM, Fraser, JF, Harley, A, Jones, P, Kinnear, F, May, K, Peake, S, Taylor, DM, Williams, J, Williams, P, Keijzers, G, Macdonald, SPJ, Udy, AA, Arendts, G, Bailey, M, Bellomo, R, Blecher, GE, Burcham, J, Delaney, A, Coggins, AR, Fatovich, DM, Fraser, JF, Harley, A, Jones, P, Kinnear, F, May, K, Peake, S, Taylor, DM, Williams, J, and Williams, P
- Abstract
OBJECTIVE: There is uncertainty about the optimal i.v. fluid volume and timing of vasopressor commencement in the resuscitation of patients with sepsis and hypotension. We aim to study current resuscitation practices in EDs in Australia and New Zealand (the Australasian Resuscitation In Sepsis Evaluation: FLUid or vasopressors In Emergency Department Sepsis [ARISE FLUIDS] observational study). METHODS: ARISE FLUIDS is a prospective, multicentre observational study in 71 hospitals in Australia and New Zealand. It will include adult patients presenting to the ED during a 30 day period with suspected sepsis and hypotension (systolic blood pressure <100 mmHg) despite at least 1000 mL fluid resuscitation. We will obtain data on baseline demographics, clinical and laboratory variables, all i.v. fluid given in the first 24 h, vasopressor use, time to antimicrobial administration, admission to intensive care, organ failure and in-hospital mortality. We will specifically describe (i) the volume of fluid administered at the following time points: when meeting eligibility criteria, in the first 6 h, at 24 h and prior to vasopressor commencement and (ii) the frequency and timing of vasopressor use in the first 6 h and at 24 h. Screening logs will provide reliable estimates of the proportion of ED patients meeting eligibility criteria for a subsequent randomised controlled trial. DISCUSSION: This multicentre, observational study will provide insight into current haemodynamic resuscitation practices in patients with sepsis and hypotension as well as estimates of practice variation and patient outcomes. The results will inform the design and feasibility of a multicentre phase III trial of early haemodynamic resuscitation in patients presenting to ED with sepsis and hypotension.
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- 2019
41. Can pre-hospital administration reduce time to initial antibiotic therapy in septic patients?
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Cudini, D, Smith, K, Bernard, S, Stephenson, M, Andrew, E, Cameron, P, Lum, M, Udy, A, Peake, S, Delaney, A, Bellomo, R, Cameron, PA, Cooper, DJ, Cross, A, Gomersall, C, Graham, C, Higgins, AM, Holdgate, A, Howe, BD, Jacobs, I, Johanson, S, Jones, P, Kruger, P, McArthur, C, Myburgh, J, Nichol, A, Pettila, V, Rajbhandari, D, Webb, SAR, Williams, A, Williams, J, Williams, P, Cudini, D, Smith, K, Bernard, S, Stephenson, M, Andrew, E, Cameron, P, Lum, M, Udy, A, Peake, S, Delaney, A, Bellomo, R, Cameron, PA, Cooper, DJ, Cross, A, Gomersall, C, Graham, C, Higgins, AM, Holdgate, A, Howe, BD, Jacobs, I, Johanson, S, Jones, P, Kruger, P, McArthur, C, Myburgh, J, Nichol, A, Pettila, V, Rajbhandari, D, Webb, SAR, Williams, A, Williams, J, and Williams, P
- Abstract
OBJECTIVE: To quantify the potential time saved with pre-hospital antibiotic therapy in sepsis. METHODS: Study data for adult patients transported by Ambulance Victoria (AV), and enrolled into the Australasian Resuscitation In Sepsis Evaluation (ARISE), were linked with pre-hospital electronic records. RESULTS: An AV record was identified for 240 of 341 ARISE patients. The pre-hospital case notes referred to potential infection in 165 patients. The median time to first antibiotic administration from loading the patient into the ambulance was 107 (74-160) min. CONCLUSIONS: ARISE patients in Victoria were frequently identified pre-hospital. An opportunity exists to study the feasibility of pre-hospital antibiotic therapy.
- Published
- 2019
42. N-ACETYLCYSTEINE PREVENTS CONTRAST NEPHROTOXICITY IN AT RISK CRITICALLY ILL PATIENTS: A PILOT STUDY
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Campbell, V, Chapman, M, Faull, R, and Peake, S
- Published
- 2004
43. Swimming performance of walleye (Stizostedion vitreum)
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Peake, S, McKinley, R S, and Scruton, D A
- Published
- 2000
44. Time to antimicrobial therapy in septic shock patients treated with an early goal‐directed resuscitation protocol: A post‐hoc analysis of the ARISE trial.
- Author
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Bulle, Esther B, Peake, Sandra L, Finnis, Mark, Bellomo, Rinaldo, Delaney, Anthony, Peake, S., Delaney, A., Bellomo, R., Cameron, P. A., Higgins, A. M., Holdgate, A., Howe, B.D., Webb, S.A.R., Williams, P., Cooper, D. J., Cross, A., Gomersall, C., Graham, C., Higgins, A.M., and Jacobs, I.
- Subjects
STATISTICS ,HOSPITAL emergency services ,CONFIDENCE intervals ,DESCRIPTIVE statistics ,RESUSCITATION ,DATA analysis ,ODDS ratio ,SEPTIC shock ,ANTIBIOTICS - Abstract
Objective: Intravenous antimicrobial therapy within 1 h of the diagnosis of septic shock is recommended in international sepsis guidelines. We aimed to evaluate the association between antimicrobial timing and mortality in patients presenting to the ED with septic shock. Methods: Post‐hoc analysis of 1587 adult participants enrolled in the Australasian Resuscitation in Sepsis Evaluation (ARISE) multicentre trial of early goal‐directed therapy for whom the time of initial antimicrobial therapy was recorded. We compared participants who had initiation of antimicrobials within the first hour (early) or later (delayed) of ED presentation. A propensity score model using inverse probability of treatment weighting was constructed to account for confounding baseline covariates. The primary outcome was 90‐day mortality. Results: The median (interquartile range) time to initiating antimicrobials was 69 (39–112) min with 712 (44.9%) participants receiving the first dose within the first hour of ED presentation. Compared with delayed therapy, early administration was associated with increased baseline illness severity score and greater intensity of resuscitation pre‐randomisation (fluid volumes, vasopressors, invasive ventilation). All‐cause 90‐day mortality was also higher; 22.6% versus 15.5%; unadjusted odds ratio (OR) 1.58 (95% confidence interval [CI] 1.16–2.15), P = 0.004. After inverse probability of treatment weighting, the mortality difference was non‐significant; OR 1.30 (95% CI 0.95–1.76), P = 0.1. Live discharge rates from ICU (OR 0.81, 95% CI 0.72–0.91; P = 0.80) and hospital (OR 0.93, 95% CI 0.82–1.06; P = 0.29) were also not different between groups. Conclusion: In this post‐hoc analysis of the ARISE trial, early antimicrobial therapy was associated with increased illness severity, but 90‐day adjusted mortality was not reduced. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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45. P640 Evaluation of dietetic services and the impact of diet on disease activity for patients with inflammatory bowel disease at Imperial College Healthcare NHS Trust
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Sandhar, H, primary, Direkze, N, additional, and Peake, S, additional
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- 2019
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46. A re-evaluation of swimming performance in juvenile salmonids relative to downstream migration
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Peake, S and McKinley, R S
- Published
- 1998
47. Relating swimming performance of lake sturgeon, Acipenser fulvescens, to fishway design
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Beamish, F WH, Peake, S, McKinley, R S, Scruton, D A, and Katopodis, C
- Published
- 1997
48. An uncommon cause of acute right ventricular failure and high mixed venous oxygen saturation
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Peake, S. L., Pavia, J. A., Bihari, D. J., and Chambers, J. B.
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- 1992
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49. Haemoglobin concentration and volume of intravenous fluids in septic shock in the ARISE trial.
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Peake S., Bellomo R., Bailey M., Delaney A., McRae S., Maiden M.J., Finnis M.E., Peake S., Bellomo R., Bailey M., Delaney A., McRae S., Maiden M.J., and Finnis M.E.
- Abstract
Background: Intravenous fluids may contribute to lower haemoglobin levels in patients with septic shock. We sought to determine the relationship between the changes in haemoglobin concentration and the volume of intravenous fluids administered during resuscitation from septic shock. Method(s): We performed a retrospective cohort study of patients enrolled in the Australasian Resuscitation in Sepsis Evaluation (ARISE) trial who were not transfused red blood cells (N = 1275). We determined the relationship between haemoglobin concentration, its change over time and volume of intravenous fluids administered over 6, 24 and 72 h using univariate and multivariate analysis. Result(s): Median (IQR) haemoglobin concentration at baseline was 133 (118-146) g/L and decreased to 115 (102-127) g/L within the first 6 h of resuscitation (P < 0.001), 110 (99-122) g/L after 24 h, and 109 (97-121) g/L after 72 h. At the corresponding time points, the cumulative volume of intravenous fluid administered was 1.3 (0.7-2.2) L, 2.9 (1.8-4.3) L and 4.6 (2.7-7.1) L. Haemoglobin concentration and its change from baseline had an independent but weak association with intravenous fluid volume at each time point (R 2 < 20%, P < 0.001). After adjusting for covariates, each litre of intravenous fluid administered was associated with a change in haemoglobin concentration of - 1.0 g/L (95% CI -1.5 to -0.6, P < 0.001) at 24 h and - 1.3 g/L (-1.6 to - 0.9, P < 0.001) at 72 h. Conclusion(s): Haemoglobin concentration decreases during resuscitation from septic shock, and has a significant but weak association with the volume of intravenous fluids administered.Copyright © 2018 The Author(s).
- Published
- 2018
50. Haemoglobin concentration and volume of intravenous fluids in septic shock in the ARISE trial
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Maiden, MJ, Finnis, ME, Peake, S, McRae, S, Delaney, A, Bailey, M, Bellomo, R, Maiden, MJ, Finnis, ME, Peake, S, McRae, S, Delaney, A, Bailey, M, and Bellomo, R
- Abstract
BACKGROUND: Intravenous fluids may contribute to lower haemoglobin levels in patients with septic shock. We sought to determine the relationship between the changes in haemoglobin concentration and the volume of intravenous fluids administered during resuscitation from septic shock. METHODS: We performed a retrospective cohort study of patients enrolled in the Australasian Resuscitation in Sepsis Evaluation (ARISE) trial who were not transfused red blood cells (N = 1275). We determined the relationship between haemoglobin concentration, its change over time and volume of intravenous fluids administered over 6, 24 and 72 h using univariate and multivariate analysis. RESULTS: Median (IQR) haemoglobin concentration at baseline was 133 (118-146) g/L and decreased to 115 (102-127) g/L within the first 6 h of resuscitation (P < 0.001), 110 (99-122) g/L after 24 h, and 109 (97-121) g/L after 72 h. At the corresponding time points, the cumulative volume of intravenous fluid administered was 1.3 (0.7-2.2) L, 2.9 (1.8-4.3) L and 4.6 (2.7-7.1) L. Haemoglobin concentration and its change from baseline had an independent but weak association with intravenous fluid volume at each time point (R2 < 20%, P < 0.001). After adjusting for covariates, each litre of intravenous fluid administered was associated with a change in haemoglobin concentration of - 1.0 g/L (95% CI -1.5 to -0.6, P < 0.001) at 24 h and - 1.3 g/L (- 1.6 to - 0.9, P < 0.001) at 72 h. CONCLUSIONS: Haemoglobin concentration decreases during resuscitation from septic shock, and has a significant but weak association with the volume of intravenous fluids administered.
- Published
- 2018
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