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1. Chagas disease in Europe

Author

Gonzalez-Sanz, Marta, Crespillo-Andujar, Clara, Chamorro-Tojeiro, Sandra, Monge-Maillo, Begona, Perez-Molina, Jose A, and Norman, Francesca F

Published
2023

4. Author Correction: Discovery of circulating miRNAs as biomarkers of chronic Chagas heart disease via a small RNA-Seq approach

Author

Villar, Silvina R., Herreros-Cabello, Alfonso, Callejas-Hernández, Francisco, Maza, María C., del Moral-Salmoral, Javier, Gómez-Montes, Mario, Rodríguez-Angulo, Héctor O., Carrillo, Irene, Górgolas, Miguel, Bosch-Nicolau, Pau, Molina, Israel, Pérez-Molina, José A., Monge-Maillo, Begoña, Bottasso, Oscar A., Beloscar, Juan, Pérez, Ana R., Fresno, Manuel, and Gironès, Núria

Published
2024
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6. Discovery of circulating miRNAs as biomarkers of chronic Chagas heart disease via a small RNA-Seq approach

Author

Villar, Silvina R., Herreros-Cabello, Alfonso, Callejas-Hernández, Francisco, Maza, María C., del Moral-Salmoral, Javier, Gómez-Montes, Mario, Rodríguez-Angulo, Héctor O., Carrillo, Irene, Górgolas, Miguel, Bosch-Nicolau, Pau, Molina, Israel, Pérez-Molina, José A., Monge-Maillo, Begoña, Bottasso, Oscar A., Beloscar, Juan, Pérez, Ana R., Fresno, Manuel, and Gironès, Núria

Published
2024
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8. Consensus definitions in imported human schistosomiasis: a GeoSentinel and TropNet Delphi study

Author

Tamarozzi, Francesca, Mazzi, Cristina, Antinori, Spinello, Arsuaga, Marta, Becker, Sören L, Bottieau, Emmanuel, Camprubi-Ferrer, Daniel, Caumes, Eric, Duvignaud, Alexandre, Grobusch, Martin P, Jaureguiberry, Stephane, Jordan, Sabine, Mueller, Andreas, Neumayr, Andreas, Perez-Molina, Jose A, Salas-Coronas, Joaquin, Salvador, Fernando, Tomasoni, Lina R, van Hellemond, Jaap J, Vaughan, Stephen D, Wammes, Linda J, Zammarchi, Lorenzo, Buonfrate, Dora, Huits, Ralph, van Lieshout, Lisette, and Gobbi, Federico

Published
2024
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9. Efficacy of three benznidazole dosing strategies for adults living with chronic Chagas disease (MULTIBENZ): an international, randomised, double-blind, phase 2b trial

Author

Bosch-Nicolau, Pau, Fernández, Marisa L, Sulleiro, Elena, Villar, Juan Carlos, Perez-Molina, José A, Correa-Oliveira, Rodrigo, Sosa-Estani, Sergio, Sánchez-Montalvá, Adrián, del Carmen Bangher, Maria, Moreira, Otacilio C, Salvador, Fernando, Mota Ferreira, Ariela, Eloi-Santos, Silvana Maria, Serre-Delcor, Núria, Ramírez, Juan Carlos, Silgado, Aroa, Oliveira, Inés, Martín, Oihane, Aznar, Maria Luisa, Ribeiro, Antonio Luiz P, Almeida, Paulo Emilio Clementino, Chamorro-Tojeiro, Sandra, Espinosa-Pereiro, Juan, de Paula, Alfredo Mauricio Batista, Váquiro-Herrera, Eliana, Tur, Carmen, and Molina, Israel

Published
2024
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12. Expanding HIV clinical monitoring: the role of CD4, CD8, and CD4/CD8 ratio in predicting non-AIDS events

Author

Jarrín, Inma, Dalmau, David, Navarro, M. Luisa, González, M. Isabel, Garcia, Federico, Poveda, Eva, Iribarren, Jose Antonio, Gutiérrez, Félix, Rubio, Rafael, Vidal, Francesc, Berenguer, Juan, González, Juan, Muñoz-Fernández, M. Ángeles, Jarrín, Inmaculada, Moreno, Cristina, Rava, Marta, Izquierdo, Rebeca, Mauleón, Elba, Portilla, Joaquín, Portilla, Irene, Merino, Esperanza, García, Gema, Agea, Iván, Sánchez-Payá, José, Rodríguez, Juan Carlos, Giner, Livia, Reus, Sergio, Boix, Vicente, Torrus, Diego, Pérez, Verónica, Portilla, Julia, Gómez, Juan Luís, Hernández, Jehovana, Lirola, Ana López, García, Dácil, Díaz-Flores, Felicitas, Alonso, M. Mar, Pelazas, Ricardo, Alemán, M. Remedios, Asensi, Víctor, Rivas Carmenado, María Eugenia, Suarez-Zarracina, Tomás, Pulido, Federico, Bisbal, Otilia, Hernando, M. Asunción, Rial, David, de Lagarde, María, Arce, Octavio, Pinto, Adriana, Bermejo, Laura, Santacreu, Mireia, Navarro, Roser, Gonzalez, Candela, Aramburu, M. José, Camino, Xabier, Ángel von Wichmann, Miguel, Goenaga, Miguel Ángel, Bustinduy, M. Jesús, Azkune, Harkaitz, Ibarguren, Maialen, Kortajarena, Xabier, Álvarez-Rodriguez, Ignacio, Gil, Leire, Martínez, Lourdes, Robledano, Catalina, Masiá, Mar, Padilla, Sergio, Adsuar, Araceli, Pascual, Rafael, Fernández, Marta, Galiana, Antonio, García, José Alberto, Barber, Xavier, Agullo, Vanessa, Abellán, Javier Garcia, Pascual, Reyes, Telenti, Guillermo, Guillén, Lucia, Botella, Ángela, Muga, Roberto, Sanvisens, Arantza, Fuster, Daniel, Gutierrez, Isabel, López, Juan Carlos, Ramírez, Margarita, Padilla, Belén, Gijón, Paloma, Aldamiz-Echevarría, Teresa, Tejerina, Francisco, Diez, Cristina, Pérez, Leire, Fanciulli, Chiara, Corral, Saray, Martí, Anna, Peraire, Joaquín, Viladés, Consuelo, Vargas, Montserrat, Olona, Montserrat, Rull, Anna, Alba, Verónica, Yeregui, Elena, Masip, Jenifer, García-Pardo, Graciano, Bertomeu, Frederic Gómez, Espineira, Sonia, Montero, Marta, Cuéllar, Sandra, Blanes, Marino, Tasias, María, Calabuig, Eva, Salavert, Miguel, Fernández, Juan, Segarra, Inmaculada, González-García, Juan, Delgado, Ana, Arnalich, Francisco, Arribas, José Ramón, Bernardino, Jose Ignacio, Castro, Juan Miguel, Escosa, Luis, Herranz, Pedro, Hontañón, Victor, García-Bujalance, Silvia, García, Milagros, González-Baeza, Alicia, Martín-Carbonero, M. Luz, Mayoral, Mario, Mellado, M. Jose, Esteban, Rafael, Montejano, Rocío, Montes, M. Luisa, Moreno, Victoria, Pérez-Valero, Ignacio, Rodés, Berta, Rúa, Guadalupe, Sainz, Talía, Sendagorta, Elena, Valencia, Eulalia, Busca, Carmen, Cano, Joanna, Cardiñanos, Julen, de Miguel, Rosa, Blanco, Jose Ramón, Pérez-Martínez, Laura, Oteo, José Antonio, Ibarra, Valvanera, Metola, Luis, Sanz, Mercedes, Arazo, Piedad, Sampériz, Gloria, Martinez, Marina, Jaén, Angels, Sanmartí, Montse, Cairó, Mireia, Martinez-Lacasa, Javier, Velli, Pablo, Font, Roser, Xercavins, Mariona, Alonso, Noemí, Aiello, Francesco, Rivero, María, Piérola, Beatriz, Goikoetxea, Maider, Gracia, María, Ibero, Carlos, Moreno, Estela, Repáraz, Jesús, Navarro, Gemma, Garcia, Manel Cervantes, Isbert, Sonia Calzado, Vilasaro, Marta Navarro, Garcia, Belen Lopez, Santos, Ignacio de los, Santos, Alejandro de los, Sanz, Jesús, García-Fraile, Lucio, Martín, Enrique, Sánchez-Cerrillo, Ildefonso, Calvet, Marta, Barrios, Ana, Bautista, Azucena, Sáez, Carmen, Ciudad, Marianela, Gutiérrez, Ángela, Moreno, Santiago, Campo, Santos del, Casado, José Luis, Dronda, Fernando, Moreno, Ana, Pérez, M. Jesús, Serrano, Sergio, Vivancos, M<ce:sup loc='post">a</ce:sup> Jesús, Martínez-Sanz, Javier, Vallejo, Alejandro, Sanchez, Matilde, Pérez-Molina, Jose Antonio, Hermida, José Manuel, Bernal, Enrique, Alcaraz, Antonia, Bravo, Joaquín, Muñoz, Ángeles, Tomás, Cristina, Martínez, Mónica, Villalba, M. Carmen, García, Federico, Martínez, Clara, Hernández, José, Medina, Leopoldo Muñoz, Álvarez, Marta, Chueca, Natalia, Vinuesa, David, de Salazar, Adolfo, Fuentes, Ana, Guirao, Emilio, Viñuela, Laura, Ruiz-Sancho, Andrés, Anguita, Francisco, Del Romero, Jorge, Raposo, Montserrat, Rodríguez, Carmen, Puerta, Teresa, Carrió, Juan Carlos, Vera, Mar, Ballesteros, Juan, Ayerdi, Oskar, Baza, Begoña, Orviz, Eva, Antela, Antonio, Losada, Elena, Riera, Melchor, Peñaranda, María, Ribas, M. Angels, Campins, Antoni A., Garcia-Gazalla, Mercedes, Fanjul, Francisco J., Murillas, Javier, Homar, Francisco, Vilchez, Helem H., Martin, Luisa, Payeras, Antoni, Santos, Jesús, López, María, Gómez, Crisitina, Viciana, Isabel, Palacios, Rosario, López-Cortés, Luis Fernando, Espinosa, Nuria, Roca, Cristina, Llaves, Silvia, Tiraboschi, Juan Manuel, Imaz, Arkaitz, Silva, Ana Karina, Saumoy, María, Scévola, Sofía Catalina, Curran, Adrián, Falcó, Vicenç, Navarro, Jordi, Burgos, Joaquin, Suanzes, Paula, García, Jorge, Descalzo, Vicente, Álvarez, Patricia, Planas, Bibiana, Sanchiz, Marta, Rodríguez, Lucía, Olalla, Julián, Sánchez, M José, Pérez, Javier, Arco, Alfonso del, Torre, Javier de la, Prada, José Luis, Martínez, Onofre Juan, Martinez, Lorena, Vera, Francisco Jesús, García, Josefina, Alcaraz, Begoña, Sánchez Guirao, Antonio Jesús, Mena, Alvaro, Castro, Angeles, Pernas, Berta, Vázquez, Pilar, López, Soledad, Ibarra, Sofía, García, Guillermo, Mirena, Josu, Ferrero, Oscar Luis, López, Josefina, Cámara, M. Mar, Peña, Mireia de la, Lopez, Miriam, Lopez, Iñigo, Lombide, Itxaso, Polo, Victor, de Miguel, Joana, Galera, Carlos, Fernández, Marian, Albendin, Helena, Castillo, Antonia, Iborra, Asunción, Moreno, Antonio, Merlos, M. Angustias, Vidal, Asunción, Amador, Concha, Pasquau, Francisco, Gil, Concepcion, Algado, Jose Tomás, Suarez-García, Inés, Malmierca, Eduardo, González-Ruano, Patricia, Ruiz, M. Pilar, Pascual, José Francisco, Sáez, Elena, Balsalobre, Luz, López, M. Villa, Omar, Mohamed, Herrero, Carmen, Gómez, M. Amparo, Alberto de Zarraga, Miguel, Pérez, Desiré, Estrada, Vicente, Sanz, Nieves, Cabello, Noemí, García, Jorge Vergas, Núñez, Maria Jose, Sagastagoitia, Iñigo, Górgolas, Miguel, Cabello, Alfonso, Álvarez, Beatriz, Prieto, Laura, Carrillo, Irene, Sanz, José, Arranz, Alberto, Hernández, Cristina, Novella, María, Galindo, M. José, Ferrer, Ana, Román, Antonio Rivero, Ruíz, Inma, Juárez, Antonio Rivero, López, Pedro, Machuca, Isabel, Frias, Mario, Camacho, Ángela, Pérez, Ignacio, Corona, Diana, Cervero, Miguel, Torres, Rafael, Pineda, Juan Antonio, Rincón, Pilar, Macías, Juan, Real, Luis Miguel, Corma, Anais, Gonzalez-Serna, Alejandro, Pérez, Alexandre, Morano, Luis, Miralles, Celia, Ocampo, Antonio, Pousada, Guillermo, Patiño, Lucía, Dueñas, Carlos, Gutiérrez, Sara, Tapia, Elena, Novoa, Cristina, Egües, Xjoylin, Telleria, Pablo, Díaz-Álvarez, Jorge, Rosas Cancio-Suarez, Marta, Ron, Raquel, Iribarren, José Antonio, Ruiz Sancho, Andrés, Cabello, Noemi, and Serrano-Villar, Sergio

Published
2023
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13. Fecal Microbiota Transplantation Alters the Proteomic Landscape of Inflammation in HIV: Identifying Bacterial Drivers

Author

Díaz-García, Claudio, primary, Moreno, Elena, additional, Talavera, Alba, additional, Martín-Fernández, Lucía, additional, Martín-Pedraza, Laura, additional, Pérez-Molina, José A., additional, González-Bodí, Sara, additional, Huerta-Cepas, Jaime, additional, Dronda, Fernando, additional, Gosalbes, María José, additional, Luna, Laura, additional, Vivancos, María Jesús, additional, Moreno, Santiago, additional, and Serrano-Villar, Sergio, additional

Published
2024
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17. Chagas disease is related to structural changes of the gut microbiota in adults with chronic infection (TRIPOBIOME Study)

Author

Pérez-Molina, José Antonio, Crespillo-Andújar, Clara, Trigo, Elena, Chamorro, Sandra, Arsuaga, Marta, Olavarrieta, Leticia, Navia Lombán, Beatriz, Martín, Ohiane, Monje-Maillo, Begoña, Norman, Francesca F, Lanza, Val F, Serrano-Villar, Sergio, Pérez-Molina, José Antonio, Crespillo-Andújar, Clara, Trigo, Elena, Chamorro, Sandra, Arsuaga, Marta, Olavarrieta, Leticia, Navia Lombán, Beatriz, Martín, Ohiane, Monje-Maillo, Begoña, Norman, Francesca F, Lanza, Val F, and Serrano-Villar, Sergio

Abstract

Background The implications of the gut microbial communities in the immune response against parasites and gut motility could explain the differences in clinical manifestations and treatment responses found in patients with chronic Chagas disease. Methodology/Principal findings In this pilot prospective cross-sectional study, we included 80 participants: 29 with indeterminate CD (ICD), 16 with cardiac CD (CCD), 15 with digestive CD (DCD), and 20 controls without CD. Stool was collected at the baseline visit and faecal microbial community structure DNA was analyzed by whole genome sequencing. We also performed a comprehensive dietary analysis. Ninety per cent (72/80) of subjects were of Bolivian origin with a median age of 47 years (IQR 39–54) and 48.3% (29/60) had received benznidazole treatment. There were no substantial differences in dietary habits between patients with CD and controls. We identified that the presence or absence of CD explained 5% of the observed microbiota variability. Subjects with CD exhibited consistent enrichment of Parabacteroides spp, while for Enterococcus hirae, Lactobacillus buchneri and Megamonas spp, the effect was less clear once excluded the outliers values. Sex, type of visceral involvement and previous treatment with benznidazole did not appear to have a confounding effect on gut microbiota structure. We also found that patients with DCD showed consistent Prevotella spp enrichment. Conclusions We found a detectable effect of Chagas disease on overall microbiota structure with several potential disease biomarkers, which warrants further research in this field. The analysis of bacterial diversity could prove to be a viable target to improve the prognosis of this prevalent and neglected disease., Unión Europea-NextGeneration EU to JAPM, CIBER -Consorcio Centro de Investigación Biomédica en Red, Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación, Depto. de Nutrición y Ciencia de los Alimentos, Fac. de Farmacia, TRUE, pub

Published
2024

18. Interactions among the mycobiome, bacteriome, inflammation, and diet in people living with HIV

Author

Gosalbes, María José, Jiménez-Hernández, Nuria, Moreno, Elena, Artacho, Alejandro, Pons, Xavier, Ruíz-Pérez, Sonia, Navia Lombán, Beatriz, Estrada, Vicente, Manzano, Mónica, Talavera-Rodríguez, Alba, Madrid, Nadia, Vallejo, Alejandro, Luna, Laura, Pérez-Molina, José Antonio, Moreno, Santiago, Serrano-Villar, Sergio, Gosalbes, María José, Jiménez-Hernández, Nuria, Moreno, Elena, Artacho, Alejandro, Pons, Xavier, Ruíz-Pérez, Sonia, Navia Lombán, Beatriz, Estrada, Vicente, Manzano, Mónica, Talavera-Rodríguez, Alba, Madrid, Nadia, Vallejo, Alejandro, Luna, Laura, Pérez-Molina, José Antonio, Moreno, Santiago, and Serrano-Villar, Sergio

Abstract

While the intestinal microbiome seems a major driver of persistent immune defects in people with HIV (PWH), little is known about its fungal component, the mycobiome. We assessed the inter-kingdom mycobiome–bacteriome interactions, the impact of diet, and the association with the innate and adaptive immunity in PWH on antiretroviral therapy. We included 24 PWH individuals and 12 healthy controls. We sequenced the Internal Transcribed Spacer 2 amplicons, determined amplicon sequence variants, measured biomarkers of the innate and adaptive immunity in blood and relations with diet. Compared to healthy controls, PWH subjects exhibited a distinct and richer mycobiome and an enrichment for Debaryomyces hansenii, Candida albicans, and Candida parapsilosis. In PWH, Candida and Pichia species were strongly correlated with several bacterial genera, including Faecalibacterium genus. Regarding the links between the mycobiome and systemic immunology, we found a positive correlation between Candida species and the levels of proinflammatory cytokines (sTNF-R2 and IL-17), interleukin 22 (a cytokine implicated in the regulation of mucosal immunity), and CD8+ T cell counts. This suggests an important role of the yeasts in systemic innate and adaptive immune responses. Finally, we identified inter-kingdom interactions implicated in fiber degradation, short-chain fatty acid production, and lipid metabolism, and an effect of vegetable and fiber intake on the mycobiome. Therefore, despite the great differences in abundance and diversity between the bacterial and fungal communities of the gut, we defined the changes associated with HIV, determined several different inter-kingdom associations, and found links between the mycobiome, nutrient metabolism, and systemic immunity, European Development Regional Found "A way to achieve Europe" (ERDF), Instituto de Salud Carlos III, Depto. de Nutrición y Ciencia de los Alimentos, Fac. de Farmacia, TRUE, pub

Published
2024

19. Screening blood donors for malaria, can we increase the number of eligible donors? An observational retrospective study.

Author

Dolores Corbacho‑Loarte, María, Martín, Oihane, Chamorro‑Tojeiro, Sandra, Crespillo‑Andújar, Clara, Norman, Francesca F., Pérez‑Molina, José A., González Sanz, Marta, Rosas Cancio‑Suárez, Marta, Ruiz‑Calvo, Gabriel, Richart López, Alberto, Miguel Rubio, José, López‑Vélez, Rogelio, and Monge‑Maillo, Begoña

Abstract

Background In non-endemic countries, malaria can be transmitted through blood donations from imported cases. To ensure standards of quality and safety of human blood, the European Union and Spanish national law, requires a deferral period, or a screening by immunological or genomic test among those donors with potential risk of malaria. Scientifc societies, European Committee on Blood Transfusion, and Spanish Society of Haematology and Haemotherapy, refer only to the result of the immunological test. Methods An observational retrospective study was performed in potential donors with a positive immunological test for malaria done in the Regional Transfusion Center in Madrid and referred to the National Reference Unit for Tropical Diseases in Madrid between 2015–2020. At consultation a Polymerase Chain Reaction (PCR) for malaria was performed. Results During the study period, 121 possible donors attended for consultation at NRU-Trop. Median age: 38.5 (IQR:33–48); median time to consultation was 32 months (IQR:12.5–110). Eighty-two (67.8%) donors were migrants and thirty-nine were travellers (32.2%). ELISA values were available for 109 subjects (90.1%), 56 individual left malaria endemic area>3 years before. All donors tested negative for Plasmodium spp PCR test (n=121, 100%). Conclusions None of the subjects with a positive immunologic test deferred as blood donors had a positive genomic test. The presence of Plasmodium spp in collected blood was not detected by molecular techniques. To avoid the loss of potential blood donors, especially those with low incidence red blood cell antigens, as more precise microbiology techniques become available, updating the existing legislation becomes necessary to increase the availability of donated blood. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Description of COVID-19 in HIV-infected individuals: a single-centre, prospective cohort

Author

Moreno, Santiago, Pérez-Elías, Maria Jesús, Fortún, Jesús, Navas, Enrique, Quereda, Carmen, Dronda, Fernando, Del Campo, Santos, López-Vélez, Rogelio, Cobo Reinoso, Javier, Casado, José Luis, Moreno, Ana, Norman, Franceca, Martín-Dávila, Pilar, Hermida, José Manuel, Pérez Molina, José Antonio, Monge, Begoña, Pintado, Vicente, Serrano-Villar, Sergio, Sánchez-Conde, Matilde, Chamorro, Sandra, Escudero, Rosa, Gioia, Francesca, Comeche, Belén, Crespillo, Clara, Herrera, Sabina, Ron, Raquel, Martínez-Sanz, Javier, Pons-Guillén, Mario, Vivancos, María Jesús, Vizcarra, Pilar, Pérez-Elías, María J, Vivancos, María J, and Casado, José L

Published
2020
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22. Corrigendum: CD4/CD8 ratio and CD8+ T-cell count as prognostic markers for non-AIDS mortality in people living with HIV. A systematic review and meta-analysis

Author

Ron, Raquel, primary, Martínez-Sanz, Javier, additional, Herrera, Sabina, additional, Ramos-Ruperto, Luis, additional, Díez-Vidal, Alejandro, additional, Sainz, Talía, additional, Álvarez-Díaz, Noelia, additional, Correa-Pérez, Andrea, additional, Muriel, Alfonso, additional, López-Alcalde, Jesús, additional, Pérez-Molina, José A., additional, Moreno, Santiago, additional, and Serrano-Villar, Sergio, additional

Published
2024
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23. CD4/CD8 ratio and CD8+ T-cell count as prognostic markers for non-AIDS mortality in people living with HIV. A systematic review and meta-analysis

Author

Ron, Raquel, primary, Martínez-Sanz, Javier, additional, Herrera, Sabina, additional, Ramos-Ruperto, Luis, additional, Díez, Alejandro, additional, Sainz, Talía, additional, Álvarez-Díaz, Noelia, additional, Correa-Pérez, Andrea, additional, Muriel, Alfonso, additional, López-Alcalde, Jesús, additional, Pérez-Molina, José A., additional, Moreno, Santiago, additional, and Serrano-Villar, Sergio, additional

Published
2024
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25. Fecal microbiota transplantation in HIV: A pilot placebo-controlled study

Author

Serrano-Villar, Sergio, Talavera-Rodríguez, Alba, Gosalbes, María José, Madrid, Nadia, Pérez-Molina, José A., Elliott, Ryan J., Navia, Beatriz, Lanza, Val F., Vallejo, Alejandro, Osman, Majdi, Dronda, Fernando, Budree, Shrish, Zamora, Javier, Gutiérrez, Carolina, Manzano, Mónica, Vivancos, María Jesús, Ron, Raquel, Martínez-Sanz, Javier, Herrera, Sabina, Ansa, Uxua, Moya, Andrés, and Moreno, Santiago

Published
2021
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26. Analysis of the costs and cost-effectiveness of the guidelines recommended by the 2018 GESIDA/Spanish National AIDS Plan for initial antiretroviral therapy in HIV-infected adults

Author

Pérez-Molina, José Antonio, Martínez, Esteban, Blasco, Antonio Javier, Arribas, José Ramón, Domingo, Pere, Iribarren, José Antonio, Knobel, Hernando, Lázaro, Pablo, López-Aldeguer, José, Lozano, Fernando, Mariño, Ana, Miró, José M., Moreno, Santiago, Negredo, Eugenia, Pulido, Federico, Rubio, Rafael, Santos, Jesús, de la Torre, Javier, Tuset, Montserrat, von Wichmann, Miguel A., and Gatell, Josep M.

Published
2019
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27. Executive summary of the GeSIDA/National AIDS Plan consensus document on antiretroviral therapy in adults infected by the human immunodeficiency virus (updated January 2018)

Author

Pérez-Molina, José A., Polo, Rosa, López-Aldeguer, José, Lozano, Fernando, Aguirrebengoa, Koldo, Arribas, José Ramón, Boix, Vicente, Berenguer, Juan, Blanco, José Ramón, Domingo, Pere, Estrada, Vicente, Galindo, María José, García, Federico, Gatell, José María, González-García, Juan, Gutiérrez, Félix, Iribarren, José Antonio, Knobel, Hernando, Llibre, Josep María, López-Bernaldo de Quirós, Juan Carlos, López-Cortés, Luis Fernando, Losa, Juan Emilio, Mariño, Ana, Miró, José M., Montes, María L., Moreno, Santiago, Negredo, Eugenia, Pérez-Elías, María J., Podzamczer, Daniel, Portilla, Joaquín, Poveda, Eva, Pulido, Federico, Ribera, Esteban, Rivero, Antonio, Rubio, Rafael, Santos, Jesús, Sanz-Moreno, José, Sanz-Sanz, Jesús, Serrano, Sergio, de la Torre, Javier, Tuset, Montserrat, von Wichman, Miguel A., and Martínez, Esteban

Published
2019
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28. COVID-19 and geographical area of origin

Author

Vizcarra, Pilar, Norman, Francesca, Crespillo, Clara, Pérez-Molina, José, Comeche, Belén, Chamorro, Sandra, Monge, Begoña, Moreno, Santiago, López-Vélez, Rogelio, Pérez-Elías, Maria Jesús, Fortún, Jesús, Navas, Enrique, Quereda, Carmen, Dronda, Fernando, Del Campo, Santos, Reinoso, Javier Cobo, Casado, José Luis, Moreno, Ana, Martín-Dávila, Pilar, Hermida, José Manuel, Pintado, Vicente, Serrano-Villar, Sergio, Sánchez-Conde, Matilde, Escudero, Rosa, Gioia, Francesca, Herrera, Sabina, Ron, Raquel, Martínez-Sanz, Javier, Pons-Guillén, Mario, Vivancos, María Jesús, Norman, Francesca F., Crespillo-Andújar, Clara, Pérez-Molina, José Antonio, Monge-Maillo, Begoña, and Moreno-Guillén, Santiago

Published
2021
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29. Costs and cost-efficacy analysis of the 2017 GESIDA/Spanish National AIDS Plan recommended guidelines for initial antiretroviral therapy in HIV-infected adults

Author

Rivero, Antonio, Pérez-Molina, José Antonio, Blasco, Antonio Javier, Arribas, José Ramón, Asensi, Víctor, Crespo, Manuel, Domingo, Pere, Iribarren, José Antonio, Lázaro, Pablo, López-Aldeguer, José, Lozano, Fernando, Martínez, Esteban, Moreno, Santiago, Palacios, Rosario, Pineda, Juan Antonio, Pulido, Federico, Rubio, Rafael, Santos, Jesús, de la Torre, Javier, Tuset, Montserrat, and Gatell, Josep M.

Published
2018
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33. Chagas disease is related to structural changes of the gut microbiota in adults with chronic infection (TRIPOBIOME Study)

Author

Pérez-Molina, José A., primary, Crespillo-Andújar, Clara, additional, Trigo, Elena, additional, Chamorro, Sandra, additional, Arsuaga, Marta, additional, Olavarrieta, Leticia, additional, Navia, Beatriz, additional, Martín, Oihane, additional, Monge-Maillo, Begoña, additional, Norman, Francesca F., additional, Lanza, Val F., additional, and Serrano-Villar, Sergio, additional

Published
2023
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34. Costs and cost-efficacy analysis of the 2016 GESIDA/Spanish AIDS National Plan recommended guidelines for initial antiretroviral therapy in HIV-infected adults

Author

Rivero, Antonio, Pérez-Molina, José Antonio, Blasco, Antonio Javier, Arribas, José Ramón, Crespo, Manuel, Domingo, Pere, Estrada, Vicente, Iribarren, José Antonio, Knobel, Hernando, Lázaro, Pablo, López-Aldeguer, José, Lozano, Fernando, Moreno, Santiago, Palacios, Rosario, Pineda, Juan Antonio, Pulido, Federico, Rubio, Rafael, de la Torre, Javier, Tuset, Montserrat, and Gatell, Josep M.

Published
2017
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36. Rickettsioses imported by travellers and migrants to Spain attended in the +Redivi network, 2009–2020

Author

Llenas-García, Jara, primary, Cañaveral, Ramiro, additional, Arsuaga, Marta, additional, Monge-Maillo, Begoña, additional, Oliveira-Souto, Inés, additional, Torrús-Tendero, Diego, additional, Rodríguez Guardado, Azucena, additional, Calabuig, Eva, additional, Sánchez-Montalvá, Adrián, additional, Domínguez-Castellano, Ángel, additional, de la Calle-Prieto, Fernando, additional, and Pérez-Molina, José A, additional

Published
2023
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37. Microbiome-derived cobalamin and succinyl-CoA as biomarkers for improved screening of anal cancer

Author

Agencia Estatal de Investigación (España), Instituto de Salud Carlos III, Lombardy Foundation for Biomedical Research, Italy, Federal Ministry of Education and Research (Germany), Research Council of Norway, Norwegian Cancer Society, European Commission, Ministerio de Ciencia e Innovación (España), Serrano-Villar, Sergio, Tincati, Camilla, Raju, Sajan C., Sáenz, Johan S., Moreno, Elena, Bargiela, Rafael, Cabello-Ubeda, Alfonso, Sendagorta, Elena, Kurz, Alina, Pérez Molina, José A., Benito, Amparo de, Hov, Johannes R., Fernández-López, Laura, Muriel, Alfonso, Campo, Rosa del, Moreno, Santiago, Trøseid, Marius, Seifert, Jana, Ferrer, Manuel, Agencia Estatal de Investigación (España), Instituto de Salud Carlos III, Lombardy Foundation for Biomedical Research, Italy, Federal Ministry of Education and Research (Germany), Research Council of Norway, Norwegian Cancer Society, European Commission, Ministerio de Ciencia e Innovación (España), Serrano-Villar, Sergio, Tincati, Camilla, Raju, Sajan C., Sáenz, Johan S., Moreno, Elena, Bargiela, Rafael, Cabello-Ubeda, Alfonso, Sendagorta, Elena, Kurz, Alina, Pérez Molina, José A., Benito, Amparo de, Hov, Johannes R., Fernández-López, Laura, Muriel, Alfonso, Campo, Rosa del, Moreno, Santiago, Trøseid, Marius, Seifert, Jana, and Ferrer, Manuel

Abstract

Human papillomavirus can cause preinvasive, high-grade squamous intraepithelial lesions (HSILs) as precursors to cancer in the anogenital area, and the microbiome is suggested to be a contributing factor. Men who have sex with men (MSM) living with human immunodeficiency virus (HIV) have a high risk of anal cancer, but current screening strategies for HSIL detection lack specificity. Here, we investigated the anal microbiome to improve HSIL screening. We enrolled participants living with HIV, divided into a discovery (n = 167) and validation cohort (n = 46), and who were predominantly (93.9%) cisgender MSM undergoing HSIL screening with high-resolution anoscopy and anal biopsies. We identified no microbiome composition signatures associated with HSILs, but elevated levels of microbiome-encoded proteins producing succinyl coenzyme A and cobalamin were significantly associated with HSILs in both cohorts. Measurement of these candidate biomarkers alone in anal cytobrushes outperformed anal cytology as a diagnostic indicator for HSILs, increasing the sensitivity from 91.2% to 96.6%, the specificity from 34.1% to 81.8%, and reclassifying 82% of false-positive results as true negatives. We propose that these two microbiome-derived biomarkers may improve the current strategy of anal cancer screening. © 2023, The Author(s), under exclusive licence to Springer Nature America, Inc.

Published
2023

38. How the microbiome can help detect precancerous lesions and prevent anal cancer

Author

Serrano-Villar, Sergio, Tincati, Camilla, Raju, Sajan C., Sáenz, Johan S., Moreno, Elena, Bargiela, Rafael, Cabello-Ubeda, Alfonso, Sendagorta, Elena, Kurz, Alina, Pérez Molina, José A., Benito, Amparo de, Hov, Johannes R., Fernández-López, Laura, Muriel, Alfonso, Campo, Rosa del, Moreno, Santiago, Trøseid, Marius, Seifert, Jana, Ferrer, Manuel, Serrano-Villar, Sergio, Tincati, Camilla, Raju, Sajan C., Sáenz, Johan S., Moreno, Elena, Bargiela, Rafael, Cabello-Ubeda, Alfonso, Sendagorta, Elena, Kurz, Alina, Pérez Molina, José A., Benito, Amparo de, Hov, Johannes R., Fernández-López, Laura, Muriel, Alfonso, Campo, Rosa del, Moreno, Santiago, Trøseid, Marius, Seifert, Jana, and Ferrer, Manuel

Abstract

[EN] This study reveals that the production of cobalamin and succinyl-CoA is increased in the anal microbiome of patients with precancerous anal lesions. Testing for these two metabolites significantly improves diagnostic accuracy over standard cytology screening, which suggests potential for enhanced screening strategies for anal cancer.

Published
2023

39. Executive summary: Prevention and treatment of opportunistic infections and other coinfections in HIV-infected patients: May 2015

Author

Iribarren, José Antonio, Rubio, Rafael, Aguirrebengoa, Koldo, Arribas, Jose Ramón, Baraia-Etxaburu, Josu, Gutiérrez, Félix, Lopez Bernaldo de Quirós, Juan Carlos, Losa, Juan Emilio, Miró, José M<ce:sup loc='post">a</ce:sup>, Moreno, Santiago, Pérez Molina, José, Podzamczer, Daniel, Pulido, Federico, Riera, Melchor, Rivero, Antonio, Sanz Moreno, José, Amador, Concha, Antela, Antonio, Arazo, Piedad, Arrizabalaga, Julio, Bachiller, Pablo, Barros, Carlos, Berenguer, Juan, Caylá, Joan, Domingo, Pere, Estrada, Vicente, Knobel, Hernando, Locutura, Jaime, López Aldeguer, José, Llibre, Josep M<ce:sup loc='post">a</ce:sup>, Lozano, Fernando, Mallolas, Josep, Malmierca, Eduardo, Miralles, Celia, Miralles, Pilar, Muñoz, Agustín, Ocampo, Agustín, Olalla, Julián, Pérez, Inés, Pérez Elías, M<ce:sup loc='post">a</ce:sup> Jesús, Pérez Arellano, José Luis, Portilla, Joaquín, Ribera, Esteban, Rodríguez, Francisco, Santín, Miguel, Sanz Sanz, Jesús, Téllez, M<ce:sup loc='post">a</ce:sup> Jesús, Torralba, Miguel, Valencia, Eulalia, and Von Wichmann, Miguel Angel

Published
2016
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42. Diagnóstico y tratamiento de la malaria importada en España: recomendaciones del Grupo de Trabajo de Malaria de la Sociedad Española de Medicina Tropical y Salud Internacional (SEMTSI)

Author

Muñoz, Jose, Rojo-Marcos, Gerardo, Ramírez-Olivencia, Germán, Salas-Coronas, Joaquín, Treviño, Begoña, Perez Arellano, José Luis, Torrús, Diego, Muñoz Vilches, Maria Jose, Ramos, Jose Manuel, Alegría, Iñaki, López-Vélez, Rogelio, Aldasoro, Edelweiss, Perez-Molina, Jose Antonio, Rubio, Jose Miguel, and Bassat, Quique

Published
2015
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43. Screening of imported malaria infection in asymptomatic migrants from Sub-Saharan Africa: A retrospective analysis of a 2010–2019 cohort

Author

Corbacho-Loarte, María Dolores, primary, Crespillo-Andújar, Clara, additional, Chamorro-Tojeiro, Sandra, additional, Norman, Francesca, additional, Pérez-Molina, José Antonio, additional, Martín, Oihane, additional, Rubio, José Miguel, additional, Gullón-Peña, Beatriz, additional, López-Vélez, Rogelio, additional, and Monge-Maillo, Begoña, additional

Published
2022
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44. Estudio sobre la aproximación al VIH: gestión sanitaria y el proceso asistencial en España

Author

De la Torre-Lima, Javier, primary, Oteo, José Antonio, additional, Pinilla, Javier, additional, Mansilla, Rosa, additional, Zamora, Carmen, additional, Ayala Vargas, Victoria, additional, Morillo-Verdugo, Ramón, additional, Moreno, Santiago, additional, Fuster-Ruiz de Apodaca, María José, additional, Pérez-Molina, José A., additional, and Colom, Joan, additional

Published
2022
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47. Interactions among the mycobiome, bacteriome, inflammation, and diet in people living with HIV

Author

Gosalbes, María José, primary, Jimenéz-Hernandéz, Nuria, additional, Moreno, Elena, additional, Artacho, Alejandro, additional, Pons, Xavier, additional, Ruíz-Pérez, Sonia, additional, Navia, Beatriz, additional, Estrada, Vicente, additional, Manzano, Mónica, additional, Talavera-Rodriguez, Alba, additional, Madrid, Nadia, additional, Vallejo, Alejandro, additional, Luna, Laura, additional, Pérez-Molina, José A., additional, Moreno, Santiago, additional, and Serrano-Villar, Sergio, additional

Published
2022
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49. Relationship of Diet to Gut Microbiota and Inflammatory Biomarkers in People with HIV

Author

Manzano, Mónica, Talavera Rodríguez, Alba, Moreno, Elena, Madrid, Nadia, Gosalbes, María José, Ron, Raquel, Dronda, Fernando, Pérez Molina, José A., Lanza, Val F., Díaz, Jorge, Moreno, Santiago, Navia, Beatriz, Serrano Villar, Sergio, Manzano, Mónica, Talavera Rodríguez, Alba, Moreno, Elena, Madrid, Nadia, Gosalbes, María José, Ron, Raquel, Dronda, Fernando, Pérez Molina, José A., Lanza, Val F., Díaz, Jorge, Moreno, Santiago, Navia, Beatriz, and Serrano Villar, Sergio

Abstract

While changes in microbiome composition have been associated with HIV, the effect of diet and its potential impact on inflammation remains unclear. Methods: Twenty-seven people living with HIV (PWH) on antiretroviral therapy (ART) were studied. A comprehensive dietary analysis was performed and two types of dietary patterns were determined. We explored the associations of each dietary pattern with gut microbiota and plasma inflammatory biomarkers. Results: We appreciated two dietary patterns, Mediterranean-like (MEL) and one Western-like (WEL). Compared to participants with the WEL pattern, participants with MEL pattern showed higher abundance of Lachnospira (p-value = 0.02) and lower levels of the inflammatory biomarkers D-dimer (p-value = 0.050) and soluble TNF-alpha receptor 2 (sTNFR2) (p-value = 0.049). Men who have sex with men (MSM) with MEL pattern had lower abundance of Erysipelotrichaceae (p-value < 0.001) and lower levels of D-dimer (p-value = 0.026) than MSM with WEL pattern. Conclusion: MEL pattern favours Lachnospira abundance, and protects against Erysipelotrichaceae abundance and higher levels of the inflammatory biomarkers D-dimer and sTNFR2, precursors of inflammatory processes in HIV-infected patients. Our study contributes to understanding the determinants of a healthier diet and its connections with gut microbiota and inflammation., Instituto de Salud Carlos III (ISCIII)/ FEDER, Depto. de Nutrición y Ciencia de los Alimentos, Fac. de Farmacia, TRUE, pub

Published
2022

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