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1. Plasma metabolite profile of legume consumption and future risk of type 2 diabetes and cardiovascular disease

Author

Margara-Escudero, Hernando J., Paz-Graniel, Indira, García-Gavilán, Jesús, Ruiz-Canela, Miguel, Sun, Qi, Clish, Clary B., Toledo, Estefania, Corella, Dolores, Estruch, Ramón, Ros, Emilio, Castañer, Olga, Arós, Fernando, Fiol, Miquel, Guasch-Ferré, Marta, Lapetra, José, Razquin, Cristina, Dennis, Courtney, Deik, Amy, Li, Jun, Gómez-Gracia, Enrique, Babio, Nancy, Martínez-González, Miguel A., Hu, Frank B., and Salas-Salvadó, Jordi

Published
2024
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2. Adulthood dietary and lifestyle patterns and risk of breast cancer: Global Cancer Update Programme (CUP Global) systematic literature review

Author

Konieczna, Jadwiga, Chaplin, Alice, Paz-Graniel, Indira, Croker, Helen, Becerra-Tomás, Nerea, Markozannes, Georgios, Tsilidis, Konstantinos K, Dossus, Laure, Gonzalez-Gil, Esther M, Park, Yikyung, Krebs, John, Weijenberg, Matty P, Baskin, Monica L, Copson, Ellen, Lewis, Sarah J, Seidell, Jacob C, Chowdhury, Rajiv, Hill, Lynette, Chan, Doris SM, and Romaguera, Dora

Published
2025
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3. Long-term association between water intake and kidney function in a population at high cardiovascular risk

Author

Paz-Graniel, Indira, Valle-Hita, Cristina, Babio, Nancy, Serra-Majem, Lluís, Vioque, Jesus, Zomeño, María Dolores, Corella, Dolores, Pintó, Xavier, Cano-Ibáñez, Naomi, Tur, Josep A., Cuadrado-Soto, Esther, Martínez, J.A., Díaz-López, Andrés, Torres-Collado, Laura, Goday, Albert, Fernández-Carrión, Rebeca, Nissenshon, Mariela, Riera-Mestre, Antoni, Garrido-Garrido, Eva, Bouzas, Cristina, Abete, Itziar, Daimiel, Lidia, Cornejo-Pareja, Isabel, Vázquez-Ruiz, Zenaida, Khoury, Nadine, Pérez-Vega, Karla Alejandra, and Salas-Salvadó, Jordi

Published
2024
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4. Effect of a nutritional intervention based on an energy-reduced Mediterranean diet on environmental impact

Author

Álvarez-Álvarez, Laura, Rubín-García, María, Vitelli-Storelli, Facundo, García, Silvia, Bouzas, Cristina, Martínez-González, Miguel Ángel, Corella, Dolores, Salas-Salvadó, Jordi, Malcampo, Mireia, Martínez, J. Alfredo, Alonso-Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramon, Tinahones, Francisco J., Lapetra, José, Serra-Majem, Lluís, Bueno-Cavanillas, Aurora, García Fernández, Camino, Pintó, Xavier, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros, Emilio, García-Arellano, Ana, Martínez, María Ángeles, Sorlí, José V., Zomeño, María Dolores, García-Rios, Antonio, González-Palacios, Sandra, Monserrat-Mesquida, Margalida, Abete, Itziar, Colom Fernández, Antoni, Casas, Rosa, Cano Ibáñez, Naomi, Ugarriza, Lucía, Bernal-López, M. Rosa, Bes-Rastrollo, Maira, Paz-Graniel, Indira, Asensio, Eva M., Fitó, Montse, Arenas Larriva, Antonio P., Oncina-Cánovas, Alejandro, Vázquez, Zenaida, Fernández de la Puente, María, Pérez-Vega, Alejandra, Tur, Josep A., and Martín-Sánchez, Vicente

Published
2024
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5. Association of adiposity and its changes over time with COVID-19 risk in older adults with overweight/obesity and metabolic syndrome: a longitudinal evaluation in the PREDIMED-Plus cohort

Author

Shyam, Sangeetha, García-Gavilán, Jesús Francisco, Paz-Graniel, Indira, Gaforio, José J., Martínez-González, Miguel Ángel, Corella, Dolores, Martínez, J. Alfredo, Alonso-Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramon, Tinahones, Francisco J., Lapetra, José, Serra-Majem, J. Luís, Bueno-Cavanillas, Aurora, Tur, Josep A., Sánchez, Vicente Martín, Pintó, Xavier, Matía-Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros, Emilio, Fernandez-Aranda, Fernando, Nishi, Stephanie K., Garcia-Regata, Oscar, Toledo, Estefania, Asensio, Eva M., Castañer, Olga, Garcia-Rios, Antonio, Torres-Collado, Laura, Gómez-Gracia, Enrique, Zulet, M. Angeles, Ruiz, Nuria Goñi, Casas, Rosa, Cano-Ibáñez, Naomi, Tojal-Sierra, Lucas, Gómez-Perez, A. M., Sorlí, Jose V., Cinza-Sanjurjo, Sergio, Martín-Peláez, Sandra, Peña-Orihuela, Patricia J., Oncina-Canovas, Alejandro, Perez-Araluce, Rafael, Zomeño, María Dolores, Chaplin, Alice, Delgado-Rodríguez, Miguel, Babio, Nancy, Fitó, Montserrat, and Salas-Salvadó, Jordi

Published
2023
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6. Plasma metabolite profiles associated with the World Cancer Research Fund/American Institute for Cancer Research lifestyle score and future risk of cardiovascular disease and type 2 diabetes

Author

Rios, Santiago, García-Gavilán, Jesús F., Babio, Nancy, Paz-Graniel, Indira, Ruiz-Canela, Miguel, Liang, Liming, Clish, Clary B, Toledo, Estefania, Corella, Dolores, Estruch, Ramón, Ros, Emilio, Fitó, Montserrat, Arós, Fernando, Fiol, Miquel, Guasch-Ferré, Marta, Santos-Lozano, José M, Li, Jun, Razquin, Cristina, Martínez-González, Miguel Ángel, Hu, Frank B, and Salas-Salvadó, Jordi

Published
2023
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7. Water intake, hydration status and 2-year changes in cognitive performance: a prospective cohort study

Author

Nishi, Stephanie K., Babio, Nancy, Paz-Graniel, Indira, Serra-Majem, Lluís, Vioque, Jesús, Fitó, Montserrat, Corella, Dolores, Pintó, Xavier, Bueno-Cavanillas, Aurora, Tur, Josep A., Diez-Ricote, Laura, Martinez, J. Alfredo, Gómez-Martínez, Carlos, González-Botella, Andrés, Castañer, Olga, Alvarez-Sala, Andrea, Montesdeoca-Mendoza, Cristina, Fanlo-Maresma, Marta, Cano-Ibáñez, Naomi, Bouzas, Cristina, Daimiel, Lidia, Zulet, María Ángeles, Sievenpiper, John L., Rodriguez, Kelly L., Vázquez-Ruiz, Zenaida, and Salas-Salvadó, Jordi

Published
2023
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10. Dietary intake of polychlorinated dibenzo-p-dioxins and furans, adiposity and obesity status.

Author

Khoury, Nadine, Martínez, María Ángeles, Paz-Graniel, Indira, Martínez-González, Miguel Ángel, Corella, Dolores, Castañer, Olga, Martínez, J. Alfredo, Alonso-Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramon, Tinahones, Francisco J., Lapetra, José, Serra-Majem, J. Lluís, Bueno-Cavanillas, Aurora, Tur, Josep A., Sanjurjo, Sergio Cinza, Pintó, Xavier, Gaforio, José Juan, Matía-Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros, Emilio, Sayon-Orea, Carmen, Sorlí, Jose V., Pérez-Vega, Karla-Alejandra, Garcia-Rios, Antonio, Bellvert, Nuria Gómez, Gómez-Gracia, Enrique, Zulet, M.A., Chaplin, Alice, Casas, Rosa, Salcedo-Bellido, Inmaculada, Tojal-Sierra, Lucas, Bernal-Lopez, Maria-Rosa, Vázquez-Ruiz, Zenaida, Asensio, Eva M., Goday, Albert, Peña-Orihuela, Patricia J., Signes-Pastor, Antonio J., Garcia-Arellano, Ana, Fitó, Montse, Babio, Nancy, and Salas-Salvadó, Jordi

Published
2023
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11. Increase from low to moderate, but not high, caffeinated coffee consumption is associated with favorable changes in body fat

Author

Henn, Matthias, Babio, Nancy, Romaguera, Dora, Vázquez-Ruiz, Zenaida, Konieczna, Jadwiga, Vioque, Jesús, Torres-Collado, Laura, Razquin, Cristina, Buil-Cosiales, Pilar, Fitó, Montserrat, Schröder, Helmut, Hu, Frank B., Abete, Itziar, Zulet, M. Ángeles, Fernández-Villa, Tania, Martín, Vicente, Estruch, Ramón, Vidal, Josep, Paz-Graniel, Indira, Martínez, J. Alfredo, Salas-Salvadó, Jordi, Martínez-González, Miguel A., and Ruiz-Canela, Miguel

Published
2023
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12. Associations Between Eating Speed, Diet Quality, Adiposity, and Cardiometabolic Risk Factors

Author

Schröder, Helmut, Moreira, Ana, Fitó, Montse, Pérez-Vega, Karla A., Baltodano, Mayela Solis, Muñoz-Aguayo, Daniel, Blanchart, Gemma, Gaixas, Sònia, Zomeño, María Dolores, Lorenzo, Isaury, Gil-Campos, Mercedes, Jurado-Castro, José Manuel, Flores-Rojas, Katherine, Pastor-Villaescusa, Belén, Llorente-Cantarero, Francisco Jesús, De La Torre-Aguilar, Maria José, Aguayo, Inmaculada Velasco, Navas-Carretero, Santiago, Alfredo-Martínez, J., Cuevillas, Begoña, Goñi, María, Hernández, María, Diez, Salomé Pérez, Cristobo, Carmen, Babio, Nancy, Salas-Salvadó, Jordi, Escribano, Joaquín, Luque, Verónica, Ferré, Natalia, Martín, Francisco, Rey, Cristina, Mimbreros, Gisela, Pedraza, Ana, Salvadó, Olga, Velasco, Marta Ruiz, Bilbao Sustacha, José Ángel, Pinilla, Yolanda Herranz, Feliu, Albert, Closas, Ricardo, Rios, Lidia, Compte, María Pascual, Gheorghita, Irina, Gómez-Martínez, Carlos, Heras-Delgado, Sara de las, Alcázar, Mireia, Simón, Olga, Torre, Sònia de la, Tudela, Càrol, Garcidueñas-Fimbres, Tany E., Leis, Rosaura, López-Rubio, Alicia, Vázquez-Cobela, Rocío, Picáns-Leis, Rosaura, Portoles, Olga, Franch, Pilar Codoñer, Corella, Dolores, Carbonell, Vanessa Martín, Sorlí, José V., Moreno, Luís A., De Miguel-Etayo, Pilar, Santaliestra-Pasias, Alba M<ce:sup loc='post">a</ce:sup>, Miguel-Berges, María Luisa, Argente-Arizon, Pilar, Gimenez-Legarre, Natalia, Flores-Barrantes, Paloma, Pérez-Gimeno, Gloria, Seral-Cortés, Miguel, Martinez, Andrea Jimeno, Maneschy, Ivie, Paz-Graniel, Indira, Jurado-Castro, Jose Manuel, Escribano, Joaquin, Moreno, Luis A., Rey-Reñones, Cristina, Martínez, J. Alfredo, Miguel-Berges, Maria Luisa, and Llorente-Cantarero, Francisco Jesus

Published
2023
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14. Inflammatory potential of diet and bone mineral density in a senior Mediterranean population: a cross-sectional analysis of PREDIMED-Plus study

Author

García-Gavilán, Jesús F., Paz-Graniel, Indira, Babio, Nancy, Romaguera, Dora, Martínez, Jose Alfredo, Martin, Vicente, Martínez, María Ángeles, Konieczna, Jadwiga, Ruiz-Canela, Miguel, de Paz Fernandez, José Antonio, Goday, Albert, Martínez-González, Miguel Ángel, Bulló, Mònica, and Salas-Salvadó, Jordi

Published
2022
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15. Association between ankle-brachial index and cognitive function in participants in the PREDIMED-Plus study: cross-sectional assessment

Author

López, Meritxell, Ríos, Angel, Romaguera, Dora, Martínez-González, Miguel Ángel, Fernández-Aranda, Fernando, Salas-Salvadó, Jordi, Corella, Dolores, Fitó, Montserrat, Vioque, Jesús, Alonso-Gómez, Ángel M., Crespo-Oliva, Edelys, Martínez, J. Alfredo, Serra-Majem, Luís, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Pintó, Xavier, Tur, Josep A., García-Ríos, Antonio, Bueno-Cavanillas, Aurora, Gaforio, José J., Matía-Martín, Pilar, Daimiel, Lidia, Sánchez-Rodríguez, Rubén, Vidal, Josep, Sanz-Martínez, Enrique, Ros, Emilio, Toledo, Estefanía, Barrubés, Laura, Barragán, Rocío, de la Torre, Rafael, Fiol, Miquel, González-Palacios, Sandra, Sorto-Sánchez, Carolina, Martín-Ruiz, María Victoria, Zulet, María Ángeles, Díaz-Collado, Fátima, Casas, Rosa, Fernández-García, José Carlos, Santos-Lozano, José Manuel, Mallorqui-Bagué, Nuria, Argelich, Emma, Lecea, Óscar, Paz-Graniel, Indira, Sorlí, José V., Cuenca, Aida, Munuera, Susana, Hernándis-Marsán, María Vicenta, Vaquero-Luna, Jessica, Ruiz-Canela, Miguel, Camacho-Barcia, Lucía, Jiménez-Murcia, Susana, Castañer, Olga, and Yáñez, Aina M.

Published
2021
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16. Asociación entre índice tobillo-brazo y rendimiento cognitivo en participantes del estudio PREDIMED-Plus: estudio transversal

Author

López, Meritxell, Ríos, Angel, Romaguera, Dora, Martínez-González, Miguel Ángel, Fernández-Aranda, Fernando, Salas-Salvadó, Jordi, Corella, Dolores, Fitó, Montserrat, Vioque, Jesús, Alonso-Gómez, Ángel M., Crespo-Oliva, Edelys, Martínez, J. Alfredo, Serra-Majem, Luís, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Pintó, Xavier, Tur, Josep A., García-Ríos, Antonio, Bueno-Cavanillas, Aurora, Gaforio, José J., Matía-Martín, Pilar, Daimiel, Lidia, Sánchez-Rodríguez, Rubén, Vidal, Josep, Sanz-Martínez, Enrique, Ros, Emilio, Toledo, Estefanía, Barrubés, Laura, Barragán, Rocío, de la Torre, Rafael, Fiol, Miquel, González-Palacios, Sandra, Sorto-Sánchez, Carolina, Martín-Ruiz, María Victoria, Zulet, María Ángeles, Díaz-Collado, Fátima, Casas, Rosa, Fernández-García, José Carlos, Santos-Lozano, José Manuel, Mallorqui-Bagué, Nuria, Argelich, Emma, Lecea, Óscar, Paz-Graniel, Indira, Sorlí, José V., Cuenca, Aida, Munuera, Susana, Hernándis-Marsán, María Vicenta, Vaquero-Luna, Jessica, Ruiz-Canela, Miguel, Camacho-Barcia, Lucía, Jiménez-Murcia, Susana, Castañer, Olga, and Yáñez, Aina M.

Published
2021
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17. Fruit consumption and cardiometabolic risk in the PREDIMED-plus study: A cross-sectional analysis

Author

Becerra-Tomás, Nerea, Paz-Graniel, Indira, Tresserra-Rimbau, Anna, Martínez-González, Miguel Á., Barrubés, Laura, Corella, Dolores, Muñoz-Martínez, Júlia, Romaguera, Dora, Vioque, Jesús, Alonso-Gómez, Ángel M., Wärnberg, Julia, Martínez, José A., Serra-Majem, Luís, Estruch, Ramon, Bernal-López, Maria R., Lapetra, José, Pintó, Xavier, Tur, Josep A., Garcia-Rios, Antonio, Riquelme Gallego, Blanca, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Daimiel, Lidia, Velilla-Zancada, Sonsoles, Vidal, Josep, Vázquez, Clotilde, Ros, Emilio, Buil-Cosiales, Pilar, Babio, Nancy, Fernández-Carrión, Rebeca, Pérez-Vega, Karla A., Morey, Marga, Torres-Collado, Laura, Tojal-Sierra, Lucas, Pérez-López, Jessica, Abete, Itziar, Cabrera, Judith P., Casas, Rosa, Fernández-García, José C., Santos-Lozano, José M., Esteve-Luque, Virginia, Bouzas, Cristina, Fernandez-Lazaro, Cesar I., Sorlí, José V., Freixer, Gala, Martín, Marian, Muñoz, Montserrat G., Salaverria-Lete, Itziar, Toledo, Estefania, Castañer, Olga, and Salas-Salvadó, Jordi

Published
2021
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18. Baseline drinking water consumption and changes in body weight and waist circumference at 2-years of follow-up in a senior Mediterranean population

Author

Paz-Graniel, Indira, Becerra-Tomás, Nerea, Babio, Nancy, Serra-Majem, Lluís, Vioque, Jesús, Zomeño, María Dolors, Corella, Dolores, Pintó, Xavier, Bueno-Cavanillas, Aurora, Tur, Josep A., Daimiel, Lidia, Zulet, M. Angeles, Palau-Galindo, Antoni, Torres-Collado, Laura, Schröder, Helmut, Gimenez-Alba, Ignacio Manuel, Nissenshon, Mariela, Galera, Ana, Riquelme-Gallego, Blanca, Bouzas, Cristina, Micó, Víctor, Martínez, J. Alfredo, Canudas, Silvia, Castañer, Olga, Vázquez-Ruiz, Z., and Salas-Salvadó, Jordi

Published
2021
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20. Mediterranean Diet Modulation of Neuroinflammation-Related Genes in Elderly Adults at High Cardiovascular Risk.

Author

Hernando-Redondo, Javier, Malcampo, Mireia, Pérez-Vega, Karla Alejandra, Paz-Graniel, Indira, Martínez-González, Miguel Ángel, Corella, Dolores, Estruch, Ramón, Salas-Salvadó, Jordi, Pintó, Xavier, Arós, Fernando, Bautista-Castaño, Inmaculada, Romaguera, Dora, Lapetra, José, Ros, Emilio, Cueto-Galán, Raquel, Fitó, Montserrat, and Castañer, Olga

Abstract

Individuals with dementia and neurodegenerative diseases (NDDs) often suffer from cardiovascular diseases (CVDs). Neuroinflammation driven by conditions involved in CVDs is linked to disruptions in the central nervous system triggering immune reactions, perpetuating an "inflammatory-like" environment. The Mediterranean diet (MedDiet), known for its anti-inflammatory and antioxidant properties, has been proposed as a key factor to attenuate these risks. Blood nuclear cell samples were collected from 134 participants of the PREDIMED trial, which randomized participants to three diets: one supplemented with extra-virgin olive oil (MedDiet-EVOO), another with nuts (MedDiet-Nuts), and a low-fat control diet. These samples were analyzed at baseline and 12-month follow-up to assess the impact of these dietary interventions on gene expression markers. We first selected target genes by analyzing intersections between NDD and CVD associations. Significant gene expression changes from baseline to 12 months were observed in the participants allocated to the MedDiet-EVOO, particularly in CDKN2A, IFNG, NLRP3, PIK3CB, and TGFB2. Additionally, TGFB2 expression changed over time in the MedDiet-Nuts group. Comparative analyses showed significant differences in TGFB2 between MedDiet-EVOO and control, and in NAMPT between MedDiet-Nuts and control. Longitudinal models adjusted for different covariates also revealed significant effects for TGFB2 and NAMPT. In conclusion, our results suggest that one year of traditional MedDiet, especially MedDiet-EVOO, modulates gene expression associated with CVD risk and NDDs in older adults at high CV risk. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Plasma metabolite profile of legume consumption and future risk of type 2 diabetes and cardiovascular disease

Author

Margara-Escudero, Hernando J, Paz-Graniel, Indira, García-Gavilán, Jesús, Ruiz-Canela, Miguel, Sun, Qi, Clish, Clary B, Toledo, Estefania, Corella, Dolores, Estruch, Ramón, Ros, Emilio, Castañer, Olga, Arós, Fernando, Fiol, Miquel, Guasch-Ferré, Marta, Lapetra, José, Razquin, Cristina, Dennis, Courtney, Deik, Amy, Li, Jun, Gómez-Gracia, Enrique, Babio, Nancy, Martínez-González, Miguel A, Hu, Frank B, Salas-Salvadó, Jordi, Margara-Escudero, Hernando J, Paz-Graniel, Indira, García-Gavilán, Jesús, Ruiz-Canela, Miguel, Sun, Qi, Clish, Clary B, Toledo, Estefania, Corella, Dolores, Estruch, Ramón, Ros, Emilio, Castañer, Olga, Arós, Fernando, Fiol, Miquel, Guasch-Ferré, Marta, Lapetra, José, Razquin, Cristina, Dennis, Courtney, Deik, Amy, Li, Jun, Gómez-Gracia, Enrique, Babio, Nancy, Martínez-González, Miguel A, Hu, Frank B, and Salas-Salvadó, Jordi

Abstract

BACKGROUND: Legume consumption has been linked to a reduced risk of type 2 diabetes (T2D) and cardiovascular disease (CVD), while the potential association between plasma metabolites associated with legume consumption and the risk of cardiometabolic diseases has never been explored. Therefore, we aimed to identify a metabolite signature of legume consumption, and subsequently investigate its potential association with the incidence of T2D and CVD.METHODS: The current cross-sectional and longitudinal analysis was conducted in 1833 PREDIMED study participants (mean age 67 years, 57.6% women) with available baseline metabolomic data. A subset of these participants with 1-year follow-up metabolomics data (n = 1522) was used for internal validation. Plasma metabolites were assessed through liquid chromatography-tandem mass spectrometry. Cross-sectional associations between 382 different known metabolites and legume consumption were performed using elastic net regression. Associations between the identified metabolite profile and incident T2D and CVD were estimated using multivariable Cox regression models.RESULTS: Specific metabolic signatures of legume consumption were identified, these included amino acids, cortisol, and various classes of lipid metabolites including diacylglycerols, triacylglycerols, plasmalogens, sphingomyelins and other metabolites. Among these identified metabolites, 22 were negatively and 18 were positively associated with legume consumption. After adjustment for recognized risk factors and legume consumption, the identified legume metabolite profile was inversely associated with T2D incidence (hazard ratio (HR) per 1 SD: 0.75, 95% CI 0.61-0.94; p = 0.017), but not with CVD incidence risk (1.01, 95% CI 0.86-1.19; p = 0.817) over the follow-up period.CONCLUSIONS: This study identified a set of 40 metabolites associated with legume consumption and with a reduced risk of T2D development in a Mediterranean population at high ri

Published
2024

22. Fluid and total water intake in a senior mediterranean population at high cardiovascular risk: demographic and lifestyle determinants in the PREDIMED-Plus study

Author

Paz-Graniel, Indira, Babio, Nancy, Serra-Majem, Luís, Vioque, Jesús, Zomeño, Maria Dolores, Corella, Dolores, Díaz-López, Andrés, Pintó, Xavier, Bueno-Cavanillas, Aurora, Tur, Josep A., Daimiel, Lidia, Martínez, J. Alfredo, Becerra-Tomás, Nerea, Navarrete-Muñoz, Eva Mª, Schröder, Helmut, Fernández-Carrión, Rebeca, Ortiz-Andrellucchi, Adriana, Corbella, Emili, Riquelme-Gallego, Blanca, Gallardo-Alfaro, Laura, Micó, Víctor, Zulet, Marian, Barrubés, Laura, Fitó, Montserrat, Ruiz-Canela, Miguel, and Salas-Salvadó, Jordi

Published
2020
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23. Adherence to a priori dietary indexes and baseline prevalence of cardiovascular risk factors in the PREDIMED-Plus randomised trial

Author

Alvarez-Alvarez, Ismael, Toledo, Estefanía, Lecea, Oscar, Salas-Salvadó, Jordi, Corella, Dolores, Buil-Cosiales, Pilar, Zomeño, María Dolores, Vioque, Jesús, Martinez, J. Alfredo, Konieczna, Jadwiga, Barón-López, Francisco J., López-Miranda, José, Estruch, Ramon, Bueno-Cavanillas, Aurora, Alonso-Gómez, Ángel M., Tur, Josep A., Tinahones, Francisco J., Serra-Majem, Lluís, Martín, Vicente, Ortega-Calvo, Manuel, Vázquez, Clotilde, Pintó, Xavier, Vidal, Josep, Daimiel, Lidia, Delgado-Rodríguez, Miguel, Matía, Pilar, González, José I., Díaz-López, Andrés, Paz-Graniel, Indira, Muñoz, Miguel A., Fito, Montse, Pertusa-Martinez, Salvador, Abete, Itziar, García-Ríos, Antonio, Ros, Emilio, Ruiz-Canela, Miguel, and Martínez-González, Miguel Á.

Published
2020
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24. Consumption of caffeinated beverages and kidney function decline in an elderly Mediterranean population with metabolic syndrome

Author

Díaz-López, Andrés, Paz-Graniel, Indira, Ruiz, Verónica, Toledo, Estefanía, Becerra-Tomás, Nerea, Corella, Dolores, Castañer, Olga, Martínez, J. Alfredo, Alonso-Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramon, Tinahones, Francisco J., Lapetra, José, Serra-Majem, Luís, Bueno-Cavanillas, Aurora, Tur, Josep A., Sánchez, Vicente Martín, Pintó, Xavier, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Villa, Tania Fernandez, Ros, Emilio, Eguaras, Sonia, Babio, Nancy, Sorlí, Jose V., Goday, Albert, Abete, Itziar, Sierra, Lucas Tojal, Barón-López, Francisco Javier, Torres-Collado, Laura, Morey, Marga, Garcia-Rios, Antonio, Casas, Rosa, Bernal-López, María Rosa, Santos-Lozano, José Manuel, Navarro, Adela, Gonzalez, Jose I., Zomeño, María Dolores, Zulet, Maria Angeles, Luna, Jessica Vaquero, Ramallal, Raul, Fitó, Montse, and Salas-Salvadó, Jordi

Published
2021
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26. Coronavirus disease 2019 is associated with long-term depressive symptoms in Spanish older adults with overweight/obesity and metabolic syndrome

Author

Shyam, Sangeetha, primary, Gómez-Martínez, Carlos, additional, Paz-Graniel, Indira, additional, Gaforio, José J., additional, Martínez-González, Miguel Ángel, additional, Corella, Dolores, additional, Fitó, Montserrat, additional, Martínez, J. Alfredo, additional, Alonso-Gómez, Ángel M., additional, Wärnberg, Julia, additional, Vioque, Jesús, additional, Romaguera, Dora, additional, López-Miranda, José, additional, Estruch, Ramon, additional, Tinahones, Francisco J., additional, Santos-Lozano, José Manuel, additional, Serra-Majem, J. Luís, additional, Bueno-Cavanillas, Aurora, additional, Tur, Josep A., additional, Martín Sánchez, Vicente, additional, Pintó, Xavier, additional, Ortiz Ramos, María, additional, Vidal, Josep, additional, Mar Alcarria, Maria, additional, Daimiel, Lidia, additional, Ros, Emilio, additional, Fernandez-Aranda, Fernando, additional, Nishi, Stephanie K., additional, García Regata, Oscar, additional, Toledo, Estefania, additional, Sorli, Jose V., additional, Castañer, Olga, additional, Garcia-Rios, Antonio, additional, Valls-Enguix, Rafael, additional, Perez-Farinos, Napoleon, additional, Zulet, M. Angeles, additional, Rayó-Gago, Elena, additional, Casas, Rosa, additional, Rivera-Izquierdo, Mario, additional, Tojal-Sierra, Lucas, additional, Damas-Fuentes, Miguel, additional, Buil-Cosiales, Pilar, additional, Fernández-Carrion, Rebeca, additional, Goday, Albert, additional, Peña-Orihuela, Patricia J., additional, Compañ-Gabucio, Laura, additional, Diez-Espino, Javier, additional, Tello, Susanna, additional, González-Pinto, Ana, additional, de la O, Víctor, additional, Delgado-Rodríguez, Miguel, additional, Babio, Nancy, additional, and Salas-Salvadó, Jordi, additional

Published
2023
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27. Coronavirus disease 2019 is associated with long-term depressive symptoms in Spanish older adults with overweight/obesity and metabolic syndrome.

Author

Shyam, Sangeetha, Gómez-Martínez, Carlos, Paz-Graniel, Indira, Gaforio, José J., Martínez-González, Miguel Ángel, Corella, Dolores, Fitó, Montserrat, Martínez, J. Alfredo, Alonso-Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramon, Tinahones, Francisco J., Santos-Lozano, José Manuel, Serra-Majem, J. Luís, Bueno-Cavanillas, Aurora, Tur, Josep A., and Martín Sánchez, Vicente

Subjects
MENTAL depression risk factors, INDEPENDENT living, MENTAL health, RESEARCH funding, COVID-19 testing, IMMUNOGLOBULINS, LOGISTIC regression analysis, REVERSE transcriptase polymerase chain reaction, DESCRIPTIVE statistics, ODDS ratio, METABOLIC syndrome, CONFIDENCE intervals, PUBLIC health, PSYCHOLOGICAL tests, OBESITY, COVID-19, PREVENTIVE health services, DISEASE complications, OLD age
Abstract

Background: The coronavirus disease 2019 (COVID-19) has serious physiological and psychological consequences. The long-term (>12 weeks post-infection) impact of COVID-19 on mental health, specifically in older adults, is unclear. We longitudinally assessed the association of COVID-19 with depression symptomatology in community-dwelling older adults with metabolic syndrome within the framework of the PREDIMED-Plus cohort. Methods: Participants (n = 5486) aged 55–75 years were included in this longitudinal cohort. COVID-19 status (positive/negative) determined by tests (e.g. polymerase chain reaction severe acute respiratory syndrome coronavirus 2, IgG) was confirmed via event adjudication (410 cases). Pre- and post-COVID-19 depressive symptomatology was ascertained from annual assessments conducted using a validated 21-item Spanish Beck Depression Inventory-II (BDI-II). Multivariable linear and logistic regression models assessed the association between COVID-19 and depression symptomatology. Results: COVID-19 in older adults was associated with higher post-COVID-19 BDI-II scores measured at a median (interquartile range) of 29 (15–40) weeks post-infection [fully adjusted β = 0.65 points, 95% confidence interval (CI) 0.15–1.15; p = 0.011]. This association was particularly prominent in women (β = 1.38 points, 95% CI 0.44–2.33, p = 0.004). COVID-19 was associated with 62% increased odds of elevated depression risk (BDI-II ≥ 14) post-COVID-19 when adjusted for confounders (odds ratio; 95% CI 1.13–2.30, p = 0.008). Conclusions: COVID-19 was associated with long-term depression risk in older adults with overweight/obesity and metabolic syndrome, particularly in women. Thus, long-term evaluations of the impact of COVID-19 on mental health and preventive public health initiatives are warranted in older adults. [ABSTRACT FROM AUTHOR]

Published
2024
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28. How Did the COVID-19 Lockdown Pandemic Affect the Depression Symptomatology in Mediterranean Older Adults with Metabolic Syndrome?

Author

Paz-Graniel, Indira, primary, Babio, Nancy, additional, Nishi, Stephanie K., additional, Martínez-González, Miguel Ángel, additional, Corella, Dolores, additional, Fitó, Montserrat, additional, Martínez, Alfredo, additional, Alonso-Gómez, Ángel M., additional, Wärnberg, Julia, additional, Vioque, Jesús, additional, Romaguera, Dora, additional, López-Miranda, José, additional, Estruch, Ramon, additional, Tinahones, Francisco J., additional, Santos-Lozano, José Manuel, additional, Serra-Majem, J. Luís, additional, Bueno-Cavanillas, Aurora, additional, Tur, Josep A., additional, Sánchez, Vicente Martín, additional, Pintó, Xavier, additional, Delgado-Rodríguez, Miguel, additional, Matía-Martín, Pilar, additional, Vidal, Josep, additional, Calderon-Sanchez, Cristina, additional, Daimiel, Lidia, additional, Ros, Emili, additional, Fernández-Aranda, Fernando, additional, Toledo, Estefania, additional, Valle-Hita, Cristina, additional, Sorli, Jose V., additional, Lassale, Camille, additional, Garcia-Rios, Antonio, additional, Oncina-Canovas, Alejandro, additional, Barón-López, Francisco Javier, additional, Zulet, M. Angeles, additional, Rayó, Elena, additional, Casas, Rosa, additional, Thomas-Carazo, Esther, additional, Tojal-Sierra, Lucas, additional, Damas-Fuentes, Miguel, additional, Ruiz-Canela, Miguel, additional, De las Heras-Delgado, Sara, additional, Fernandez-Carrión, Rebeca, additional, Castañer, Olga, additional, Peña-Orihuela, Patricia J., additional, Gonzalez-Palacios, Sandra, additional, Buil-Cosiales, Pilar, additional, Goday, Albert, additional, and Salas-Salvadó, Jordi, additional

Published
2023
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30. Abstract P622: Increase From Low to Moderate Consumption of Caffeinated Coffee is Associated With Favorable Changes in Body Fat

Author

Henn, Matthias, primary, Babio, Nancy, additional, Maria, Romaguera, additional, Vázquez-Ruiz, Zenaida, additional, Konieczna, Jadwiga, additional, Vioque, Jesús, additional, Torres-Collado, Laura, additional, Razquin, Cristina, additional, Buil-Cosiales, Pilar, additional, Fitó, Montserrat, additional, Schröder, Helmut, additional, Hu, Frank, additional, Abete, Itziar, additional, Zulet, Maria de los Ángeles, additional, Fernández-Villa, Tania, additional, Martín, Vicente, additional, Estruch, Ramón, additional, Vidal, Josep, additional, Paz-Graniel, Indira, additional, Martínez, J. Alfredo, additional, Salas-Salvadó, Jordi, additional, Martínez-González, Miguel A., additional, and Ruiz-Canela, Miguel, additional

Published
2023
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32. Impact of COVID-19 pandemic on the PREDIMED-Plus randomized clinical trial: Effects on the interventions, participants follow-up, and adiposity

Author

Paz Graniel, Indira, Colomer, Montserrat, Ros Rahola, Emilio, Buil Cosiales, Pilar, Corella Piquer, Dolores, Babio, Nancy, Martínez, J. Alfredo, 1957, Alonso Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López Miranda, José, Estruch Riba, Ramon, Tinahones, Francisco J., Lapetra, José, Serra Majem, Lluís, Bueno Cavanillas, Aurora, Tur, Josep A., Martín Sánchez, Vicente, Pintó Sala, Xavier, Gaforio, José J., Matía Martín, Pilar, Vidal i Cortada, Josep, Vázquez, Clotilde, Daimiel, Lidia, García Gavilán, Jesús, Toledo Atucha, Estefanía, Nishi, Stephanie K., Sorlí, José V., Castañer, Olga, García Ríos, Antonio, García de la Hera, Manuela, Barón López, Francisco Javier, Ruiz Canela, Miguel, Morey, Marga, Casas Rodríguez, Rosa M., Garrido Aguilar, Eva María, Tojal Sierra, Lucas, Fernández García, José C., Vázquez Ruiz, Zenaida, Fernández Carrión, Rebeca, Goday Arnó, Albert, Peña Orihuela, Patricia J., Compañ Gabucio, Laura, Schröder, Helmut, 1958, Martínez-González, Miguel Ángel, 1957, and Salas Salvadó, Jordi

Subjects
Weight loss, Nutrition and Dietetics, Endocrinology, Diabetes and Metabolism, Mediterraean diet, COVID-19, PREDIMED-Plus, clinical trial, Clinical trial, lockdown, Aprimament, Mediterranean cooking, Clinical trials, Weight-loss, Cuina mediterrània, Lockdown, Assaigs clínics, weight-loss, Food Science
Abstract

Background: The COVID-19 pandemic has affected the implementation of most ongoing clinical trials worldwide including the PREDIMED-Plus study. The PREDIMED-Plus is an ongoing, multicenter, controlled intervention trial, aimed at weight-loss and cardiovascular disease prevention, in which participants were randomized (1:1 ratio) to an intervention group (energyreduced Mediterranean diet, promotion of physical activity, and behavioral support) or to a control group (Mediterranean diet with usual care advice). When the pandemic began, the trial was in the midst of the planned intervention. The objective of this report was to examine the effects of the pandemic on the delivery of the intervention and to describe the strategies established to mitigate the possible adverse effects of the pandemic lockdown on data collection and adiposity. Methods: We assessed the integrity of the PREDIMED-Plus trial during 5 identified periods of the COVID-19 pandemic determined according to restrictions dictated by the Spanish government authorities. A standardized questionnaire was delivered to each of the 23 PREDIMED-Plus recruiting centers to collected data regarding the trial integrity. The effect of the restrictions on intervention components (diet, physical activity) was evaluated with data obtained in the three identified lockdown phases: pre lockdown, lockdown proper, and post lockdown. Results: During the lockdown (March/2020-June/2021), 4,612 participants (48% women, mean age 65y) attended pre-specified yearly follow-up visits to receive lifestyle recommendations and obtain adiposity measures. The overall mean (SD) of the proportions reported by each center showed that 40.4% (25.4) participants had in-person visits, 39.8% (18.2) participants were contacted by telephone and 35% (26.3) by electronic means. Participants’ follow-up and data collection rates increased across lockdown periods (from 10% at onset to 80% at the end). Compared to pre-lockdown, waist circumference increased during (0.75 cm [95% CI: 0.60–0.91]) and after (0.72 cm [95% CI: 0.56–0.89]) lockdown. Body weight did not change during lockdown (0.01 kg [95% CI: –0.10 to 0.13) and decreased after lockdown (-0.17 kg [95% CI: –0.30 to –0.04]). Conclusion: Mitigating strategies to enforce the intervention and patient’s follow-up during lockdown have been successful in preserving the integrity of the trial and ensuring its continuation, with minor effects on adiposity., Instituto de Salud Carlos III (ISCIII), through the Fondo de Investigacion para la Salud (FIS) European Commission PI13/00673 PI13/00492 PI13/00272 PI13/01123 PI13/00462 PI13/00233 PI13/02184 PI13/00728 PI13/01090 PI13/01056 PI14/01722 PI14/00636 PI14/00618 PI14/00696 PI14/01206, Especial Action Project, European Research Council (ERC) European Commission 340918 2013ACUP00194, Junta de Andalucia PI0458/2013 PS0358/2016 PI0137/2018, Center for Forestry Research & Experimentation (CIEF) PROMETEO/2017/017 PROMETEO 21/2021, Department of Health of the Generalitat de Catalunya SLT006/17/00246, Spanish Government FPU 17/01925, Fundacion Francisco Soria Melguizo, ICREA under the ICREA Academia programme, Canadian Institutes of Health Research (CIHR), A European Regional Development Fund PI14/01919 PI14/00853 PI14/01374 PI14/00972 PI14/00728 PI14/01471 PI16/00473 PI16/00662 PI16/01873 PI16/01094 PI16/00501 PI16/00533 PI16/00381 PI16/00366 PI16/01522 PI16/01120 PI17/00764 PI17/01183 PI17/00855, The European Regional Development Fund PI19/00386 PI19/00309 PI19/01032 PI19/00576 PI19/00017 PI19/01226 PI19/00781 PI19/01560 PI19/01332 PI20/01802 PI20/00138 PI20/01532 PI20/00456 PI20/00339 PI20/00557 PI20/00886 PI20/01158

Published
2023
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33. Additional file 1 of Water intake, hydration status and 2-year changes in cognitive performance: a prospective cohort study

Author

Nishi, Stephanie K., Babio, Nancy, Paz-Graniel, Indira, Serra-Majem, Lluís, Vioque, Jesús, Fitó, Montserrat, Corella, Dolores, Pintó, Xavier, Bueno-Cavanillas, Aurora, Tur, Josep A., Diez-Ricote, Laura, Martinez, J. Alfredo, Gómez-Martínez, Carlos, González-Botella, Andrés, Castañer, Olga, Alvarez-Sala, Andrea, Montesdeoca-Mendoza, Cristina, Fanlo-Maresma, Marta, Cano-Ibáñez, Naomi, Bouzas, Cristina, Daimiel, Lidia, Zulet, María Ángeles, Sievenpiper, John L., Rodriguez, Kelly L., Vázquez-Ruiz, Zenaida, and Salas-Salvadó, Jordi

Abstract

Additional file 1: Table S1. Hydration and water intake definitions. Table S2. Associations between cognitive assessments and water and fluid intake exposures. Table S3. Associations between cognitive assessments and EFSA fluid intake related guidelines. Table S4. Associations between cognitive assessments and hydration status. Table S5. Sensitivity analysis in global cognitive function according to water and fluid intake related exposures Table S6. Sensitivity analysis in global cognitive function according to EFSA fluid intake related guidelines. Table S7. Sensitivity analysis in global cognitive function according to hydration status. Fig. S1. Flow diagram of participants. Fig. S2. Continuous sensitivity analysis by sex. Fig. S3. Categorical sensitivity analysis by sex.

Published
2023
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34. Associations Between Eating Speed, Diet Quality, Adiposity, and Cardiometabolic Risk Factors

Author

Garcidueñas-Fimbres, Tany E., primary, Paz-Graniel, Indira, additional, Gómez-Martínez, Carlos, additional, Jurado-Castro, Jose Manuel, additional, Leis, Rosaura, additional, Escribano, Joaquin, additional, Moreno, Luis A., additional, Navas-Carretero, Santiago, additional, Portoles, Olga, additional, Pérez-Vega, Karla A., additional, Gil-Campos, Mercedes, additional, López-Rubio, Alicia, additional, Rey-Reñones, Cristina, additional, De Miguel-Etayo, Pilar, additional, Martínez, J. Alfredo, additional, Flores-Rojas, Katherine, additional, Vázquez-Cobela, Rocío, additional, Luque, Verónica, additional, Miguel-Berges, Maria Luisa, additional, Pastor-Villaescusa, Belén, additional, Llorente-Cantarero, Francisco Jesus, additional, Salas-Salvadó, Jordi, additional, Babio, Nancy, additional, Schröder, Helmut, additional, Moreira, Ana, additional, Fitó, Montse, additional, Baltodano, Mayela Solis, additional, Muñoz-Aguayo, Daniel, additional, Blanchart, Gemma, additional, Gaixas, Sònia, additional, Zomeño, María Dolores, additional, Lorenzo, Isaury, additional, Jurado-Castro, José Manuel, additional, Llorente-Cantarero, Francisco Jesús, additional, De La Torre-Aguilar, Maria José, additional, Aguayo, Inmaculada Velasco, additional, Alfredo-Martínez, J., additional, Cuevillas, Begoña, additional, Goñi, María, additional, Hernández, María, additional, Diez, Salomé Pérez, additional, Cristobo, Carmen, additional, Escribano, Joaquín, additional, Ferré, Natalia, additional, Martín, Francisco, additional, Rey, Cristina, additional, Mimbreros, Gisela, additional, Pedraza, Ana, additional, Salvadó, Olga, additional, Velasco, Marta Ruiz, additional, Bilbao Sustacha, José Ángel, additional, Pinilla, Yolanda Herranz, additional, Feliu, Albert, additional, Closas, Ricardo, additional, Rios, Lidia, additional, Compte, María Pascual, additional, Gheorghita, Irina, additional, Heras-Delgado, Sara de las, additional, Alcázar, Mireia, additional, Simón, Olga, additional, Torre, Sònia de la, additional, Tudela, Càrol, additional, Garcidueñas-Fimbres, Tany E., additional, Picáns-Leis, Rosaura, additional, Franch, Pilar Codoñer, additional, Corella, Dolores, additional, Carbonell, Vanessa Martín, additional, Sorlí, José V., additional, Moreno, Luís A., additional, Santaliestra-Pasias, Alba Ma, additional, Miguel-Berges, María Luisa, additional, Argente-Arizon, Pilar, additional, Gimenez-Legarre, Natalia, additional, Flores-Barrantes, Paloma, additional, Pérez-Gimeno, Gloria, additional, Seral-Cortés, Miguel, additional, Martinez, Andrea Jimeno, additional, and Maneschy, Ivie, additional

Published
2023
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35. Plasma Metabolite Profiles Associated with the Amount and Source of Meat and Fish Consumption and the Risk of Type 2 Diabetes

Author

García‐Gavilán, Jesús, primary, Nishi, Stephanie K., additional, Paz‐Graniel, Indira, additional, Guasch‐Ferré, Marta, additional, Razquin, Cristina, additional, Clish, Clary B., additional, Toledo, Estefanía, additional, Ruiz‐Canela, Miguel, additional, Corella, Dolores, additional, Deik, Amy, additional, Drouin‐Chartier, Jean‐Philippe, additional, Wittenbecher, Clemens, additional, Babio, Nancy, additional, Estruch, Ramon, additional, Ros, Emilio, additional, Fitó, Montserrat, additional, Arós, Fernando, additional, Fiol, Miquel, additional, Serra‐Majem, Lluís, additional, Liang, Liming, additional, Martínez‐González, Miguel A., additional, Hu, Frank B., additional, and Salas‐Salvadó, Jordi, additional

Published
2022
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37. Ultra-processed food intake and eating disorders: Cross-sectional associations among French adults

Author

Figueiredo, Natasha, primary, Kose, Junko, additional, Srour, Bernard, additional, Julia, Chantal, additional, Kesse-Guyot, Emmanuelle, additional, Péneau, Sandrine, additional, Allès, Benjamin, additional, Paz Graniel, Indira, additional, Chazelas, Eloi, additional, Deschasaux-Tanguy, Mélanie, additional, Debras, Charlotte, additional, Hercberg, Serge, additional, Galan, Pilar, additional, Monteiro, Carlos A., additional, Touvier, Mathilde, additional, and Andreeva, Valentina A., additional

Published
2022
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40. Total dairy consumption in relation to overweight and obesity in children and adolescents: a systematic review and meta-analysis

Author

Babio, Nancy, Becerra‐Tomás, Nerea, Nishi, Stephanie K., López‐González, Leyre, Paz‐Graniel, Indira, García‐Gavilán, Jesús, Schröder, Helmut, Martín‐Calvo, Nerea, and Salas‐Salvadó, Jordi

Subjects
NUTRITIONAL-STATUS, Pediatric Obesity, MILK CONSUMPTION, Adolescent, 030309 nutrition & dietetics, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, EXCESS ADIPOSITY, Dairy, 03 medical and health sciences, Endocrinology & Metabolism, FECAL FAT EXCRETION, 0302 clinical medicine, Animals, Humans, Prospective Studies, Obesity, Child, 11 Medical and Health Sciences, 2. Zero hunger, 0303 health sciences, Science & Technology, DIETARY CALCIUM, Public Health, Environmental and Occupational Health, BEVERAGE CONSUMPTION, Overweight, 3. Good health, Diet, 17 Psychology and Cognitive Sciences, BODY-MASS INDEX, PHYSICAL-ACTIVITY, Cross-Sectional Studies, Milk, FOOD-CONSUMPTION, Dairy Products, CHILDHOOD OBESITY, Life Sciences & Biomedicine
Abstract

A systematic review and meta-analysis of cross-sectional and prospective cohort studies was conducted to assess the associations between total dairy consumption and its different subtypes with the prevalence and incidence of overweight, obesity, and overweight/obesity in children and adolescents. A literature search was conducted in Medline through PUBMED and Cochrane Library databases until October 18, 2021. Articles reporting the risk estimates as odd ratios (OR), risk ratios (RR), or hazard ratios and their corresponding 95% confidence interval (CI) for the association between dairy product consumption and the risk of overweight and/or obesity were included. In the meta-analysis from cross-sectional studies, results showed an inverse association between total dairy consumption and obesity prevalence (OR (95% CI): 0.66 (0.48-0.91). No significant associations were found between milk or yogurt and obesity prevalence risk. Regarding prospective studies, total milk consumption was positively associated with overweight prevalence (OR (95% CI): 1.13 (1.01-1.26)) and incidence (RR (95%CI): 1.17 (1.01-1.35)) risk. Evidence from pooled analysis of cross-sectional studies suggested an inverse association between total dairy consumption and obesity. However, there is limited and no conclusive evidence to confirm an inverse relationship from pooled analysis of prospective studies in children and adolescents. This paper and this supplement issue on Determinants of Childhood Obesity are ancillary endeavor part of the European Science & Technology in childhood Obesity Policy (STOP) project (H2020 SC2; ref. 774548). J. Salas-Salvadó, the senior author, gratefully acknowledges the financial support by ICREA under the ICREA Academia program. Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBEROBN) is an initiative of the Instituto de Salud Carlos III (ISCIII) of Spain, which is financed by the European Regional Development Fund (ERDF), “A way to make Europe”/”Investing in your future” (CB06/03). It is supported by the official funding agency for biomedical research of the Spanish government, ISCIII, Spain. Dr. Nerea Becerra-Tomás was supported by a postdoctoral fellowship (Juan de la Cierva-Formación, FJC2018-036016-I. Dr. Stephanie K. Nishi was supported by a postdoctoral fellowship from the Canadian Institutes of Health Research (CIHR). Indira Paz Graniel was supported of the Ministerio de Ciencia, Innovación y Universidades (MICINN) granted to I. P.-G. (FPU 17/01925). None of the funding sources played a role in the study design; in the collection, analysis, or interpretation of the data; or in the decision to submit the manuscript for publication.

Published
2022

42. Inflammatory potential of diet and bone mineral density in a senior Mediterranean population: a cross-sectional analysis of PREDIMED-Plus study

Author

García-Gavilán, Jesús F., primary, Paz-Graniel, Indira, additional, Babio, Nancy, additional, Romaguera, Dora, additional, Martínez, Jose Alfredo, additional, Martin, Vicente, additional, Martínez, María Ángeles, additional, Konieczna, Jadwiga, additional, Ruiz-Canela, Miguel, additional, de Paz Fernandez, José Antonio, additional, Goday, Albert, additional, Martínez-González, Miguel Ángel, additional, Bulló, Mònica, additional, and Salas-Salvadó, Jordi, additional

Published
2021
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43. Metabolic, Affective and Neurocognitive Characterization of Metabolic Syndrome Patients with and without Food Addiction. Implications for Weight Progression

Author

Camacho-Barcia, Lucía, primary, Munguía, Lucero, additional, Lucas, Ignacio, additional, de la Torre, Rafael, additional, Salas-Salvadó, Jordi, additional, Pintó, Xavier, additional, Corella, Dolores, additional, Granero, Roser, additional, Jiménez-Murcia, Susana, additional, González-Monje, Inmaculada, additional, Esteve-Luque, Virginia, additional, Cuenca-Royo, Aida, additional, Gómez-Martínez, Carlos, additional, Paz-Graniel, Indira, additional, Forcano, Laura, additional, and Fernández-Aranda, Fernando, additional

Published
2021
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45. Consumption of Caffeinated Beverages and Kidney Function Decline in an Elderly Mediterranean Population with Metabolic Syndrome

Author

Medicina, Medikuntza, Díaz López, Andrés, Paz Graniel, Indira, Ruiz, Verónica, Toledo, Estefanía, Becerra Tomás, Nerea, Corella, Dolores, Castañer, Olga, Martínez Hernández, José Alfredo, Alonso Gómez, Ángel María, Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López Miranda, José, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Serra Majem, Lluís, Bueno Cavanillas, Aurora, Tur, Josep A., Martín Sánchez, Vicente, Pintó, Xavier, Delgado Rodríguez, Miguel, Matía Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Fernández Villa, Tania, Ros, Emilio, Eguaras, Sonia, Babio, Nancy, Sorli, José Vicente, Goday, Albert, Abete, Itziar, Tojal Sierra, Lucas, Barón López, Francisco Javier, Torres Collado, Laura, Morey, Marga, García Ríos, Antonio, Casas, Rosa, Bernal López, María Rosa, Santos Lozano, José Manuel, Navarro, Adela, González, José I., Zomeño Blanquerna, María Dolores, Zulet, M. Ángeles, Vaquero Luna, Jessica, Ramallal, Raul, Fitó, Montserrat, Salas Salvadó, Jordi, Medicina, Medikuntza, Díaz López, Andrés, Paz Graniel, Indira, Ruiz, Verónica, Toledo, Estefanía, Becerra Tomás, Nerea, Corella, Dolores, Castañer, Olga, Martínez Hernández, José Alfredo, Alonso Gómez, Ángel María, Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López Miranda, José, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Serra Majem, Lluís, Bueno Cavanillas, Aurora, Tur, Josep A., Martín Sánchez, Vicente, Pintó, Xavier, Delgado Rodríguez, Miguel, Matía Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Fernández Villa, Tania, Ros, Emilio, Eguaras, Sonia, Babio, Nancy, Sorli, José Vicente, Goday, Albert, Abete, Itziar, Tojal Sierra, Lucas, Barón López, Francisco Javier, Torres Collado, Laura, Morey, Marga, García Ríos, Antonio, Casas, Rosa, Bernal López, María Rosa, Santos Lozano, José Manuel, Navarro, Adela, González, José I., Zomeño Blanquerna, María Dolores, Zulet, M. Ángeles, Vaquero Luna, Jessica, Ramallal, Raul, Fitó, Montserrat, and Salas Salvadó, Jordi

Abstract

It remains unclear whether caffeinated beverages could have deleterious renal effects in elderly population with underlying comorbid conditions. We investigated the associations between coffee, tea, or caffeine intake and 1-year changes in glomerular filtration rate (eGFR) in a large Spanish cohort of overweight/obese elderly with metabolic syndrome (MetS). This prospective analysis includes 5851 overweight/obese adults (55–75 years) with MetS from the PREDIMED-Plus study. We assessed coffee, tea, and caffeine consumption from a validated food-frequency questionnaire and creatinine-based eGFR using the Chronic Kidney Disease Epidemiology Collaboration equation. Multivariate-adjusted regression models were applied to test associations between baseline coffee, tea, or caffeine intake and 1-year eGFR changes. Caffeinated coffee (> 2 cups/day) and tea (at least 1 cup/day) drinkers had 0.88 and 0.93 mL/min/1.73 m2 greater eGFR decrease respectively, compared to those with less than 1 cup/day of coffee consumption or non-tea drinkers. Furthermore, caffeinated coffee consumption of > 2 cups/day was associated with 1.19-fold increased risk of rapid eGFR decline > 3 mL/min/1.73 m2 (95% CI 1.01–1.41). Similarly, individuals in the highest (median, 51.2 mg/day) tertile of caffeine intake had a 0.87 mL/min/1.73 m2 greater eGFR decrease. Decaffeinated coffee was not associated with eGFR changes. In conclusion, higher consumption of caffeinated coffee, tea, and caffeine was associated with a greater 1-year eGFR decline in overweight/obese adults with MetS.

Published
2021

46. Consumption of caffeinated beverages and kidney function decline in an elderly Mediterranean population with metabolic syndrome

Author

Universidad de Sevilla. Departamento de Medicina, Instituto de Salud Carlos III, Díaz-López, Andrés, Paz-Graniel, Indira, Ruiz, Verónica, Toledo, Estefanía, Becerra-Tomás, Nerea, Corella, Dolores, Santos Lozano, José Manuel, Salas-Salvadó, Jordi, Universidad de Sevilla. Departamento de Medicina, Instituto de Salud Carlos III, Díaz-López, Andrés, Paz-Graniel, Indira, Ruiz, Verónica, Toledo, Estefanía, Becerra-Tomás, Nerea, Corella, Dolores, Santos Lozano, José Manuel, and Salas-Salvadó, Jordi

Abstract

It remains unclear whether cafeinated beverages could have deleterious renal efects in elderly population with underlying comorbid conditions. We investigated the associations between cofee, tea, or cafeine intake and 1-year changes in glomerular fltration rate (eGFR) in a large Spanish cohort of overweight/obese elderly with metabolic syndrome (MetS). This prospective analysis includes 5851 overweight/obese adults (55–75 years) with MetS from the PREDIMED-Plus study. We assessed cofee, tea, and cafeine consumption from a validated food-frequency questionnaire and creatinine-based eGFR using the Chronic Kidney Disease Epidemiology Collaboration equation. Multivariate-adjusted regression models were applied to test associations between baseline cofee, tea, or cafeine intake and 1-year eGFR changes. Cafeinated cofee (>2 cups/day) and tea (at least 1 cup/day) drinkers had 0.88 and 0.93 mL/min/1.73 ­m2 greater eGFR decrease respectively, compared to those with less than 1 cup/day of cofee consumption or non-tea drinkers. Furthermore, cafeinated cofee consumption of > 2 cups/day was associated with 1.19-fold increased risk of rapid eGFR decline> 3 mL/min/1.73 ­m2 (95% CI 1.01–1.41). Similarly, individuals in the highest (median, 51.2 mg/day) tertile of cafeine intake had a 0.87 mL/min/1.73 ­m2 greater eGFR decrease. Decafeinated cofee was not associated with eGFR changes. In conclusion, higher consumption of cafeinated cofee, tea, and cafeine was associated with a greater 1-year eGFR decline in overweight/obese adults with MetS.

Published
2021

47. Consumption of caffeinated beverages and kidney function decline in an elderly Mediterranean population with metabolic syndrome

Author

Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (España), Instituto de Salud Carlos III, European Research Council, European Commission, Junta de Andalucía, Generalitat Valenciana, AstraZeneca, Govern de les Illes Balears, Ministerio de Educación, Cultura y Deporte (España), Institución Catalana de Investigación y Estudios Avanzados, Díaz-López, Andrés, Paz-Graniel, Indira, Ruiz, Verónica, Toledo, Estefanía, Becerra-Tomás, Nerea, Corella, Dolores, Castañer, Olga, Martínez, J. Alfredo, Alonso-Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Serra-Majem, Luís, Bueno-Cavanillas, Aurora, Tur, Josep A., Martín Sánchez, Vicente, Pintó, Xavier, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Fernández-Villa, Tania, Ros, Emilio, Eguaras, Sonia, Babio, Nancy, Sorlí, Jose V., Goday, Albert, Abete, Itziar, Tojal-Sierra, Lucas, Barón-López, Francisco Javier, Torres-Collado, Laura, Morey, Marga, Garcia-Rios, Antonio, Casas, Rosa, Bernal-López, María Rosa, Santos-Lozano, José Manuel, Navarro, Adela, González, José I., Zomeño Fajardo, Maria Dolores, Zulet, M. Ángeles, Vaquero-Luna, Jessica, Ramallal, Raúl, Fitó, Montserrat, Salas-Salvadó, Jordi, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (España), Instituto de Salud Carlos III, European Research Council, European Commission, Junta de Andalucía, Generalitat Valenciana, AstraZeneca, Govern de les Illes Balears, Ministerio de Educación, Cultura y Deporte (España), Institución Catalana de Investigación y Estudios Avanzados, Díaz-López, Andrés, Paz-Graniel, Indira, Ruiz, Verónica, Toledo, Estefanía, Becerra-Tomás, Nerea, Corella, Dolores, Castañer, Olga, Martínez, J. Alfredo, Alonso-Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Serra-Majem, Luís, Bueno-Cavanillas, Aurora, Tur, Josep A., Martín Sánchez, Vicente, Pintó, Xavier, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Fernández-Villa, Tania, Ros, Emilio, Eguaras, Sonia, Babio, Nancy, Sorlí, Jose V., Goday, Albert, Abete, Itziar, Tojal-Sierra, Lucas, Barón-López, Francisco Javier, Torres-Collado, Laura, Morey, Marga, Garcia-Rios, Antonio, Casas, Rosa, Bernal-López, María Rosa, Santos-Lozano, José Manuel, Navarro, Adela, González, José I., Zomeño Fajardo, Maria Dolores, Zulet, M. Ángeles, Vaquero-Luna, Jessica, Ramallal, Raúl, Fitó, Montserrat, and Salas-Salvadó, Jordi

Abstract

It remains unclear whether caffeinated beverages could have deleterious renal effects in elderly population with underlying comorbid conditions. We investigated the associations between coffee, tea, or caffeine intake and 1-year changes in glomerular filtration rate (eGFR) in a large Spanish cohort of overweight/obese elderly with metabolic syndrome (MetS). This prospective analysis includes 5851 overweight/obese adults (55–75 years) with MetS from the PREDIMED-Plus study. We assessed coffee, tea, and caffeine consumption from a validated food-frequency questionnaire and creatinine-based eGFR using the Chronic Kidney Disease Epidemiology Collaboration equation. Multivariate-adjusted regression models were applied to test associations between baseline coffee, tea, or caffeine intake and 1-year eGFR changes. Caffeinated coffee (> 2 cups/day) and tea (at least 1 cup/day) drinkers had 0.88 and 0.93 mL/min/1.73 m greater eGFR decrease respectively, compared to those with less than 1 cup/day of coffee consumption or non-tea drinkers. Furthermore, caffeinated coffee consumption of > 2 cups/day was associated with 1.19-fold increased risk of rapid eGFR decline > 3 mL/min/1.73 m (95% CI 1.01–1.41). Similarly, individuals in the highest (median, 51.2 mg/day) tertile of caffeine intake had a 0.87 mL/min/1.73 m greater eGFR decrease. Decaffeinated coffee was not associated with eGFR changes. In conclusion, higher consumption of caffeinated coffee, tea, and caffeine was associated with a greater 1-year eGFR decline in overweight/obese adults with MetS.

Published
2021

49. Association between the Potential Influence of a Lifestyle Intervention in Older Individuals with Excess Weight and Metabolic Syndrome on Untreated Household Cohabitants and Their Family Support: The PREDIMED-Plus Study

Author

Basora, Josep, primary, Villalobos, Felipe, additional, Pallejà-Millán, Meritxell, additional, Babio, Nancy, additional, Goday, Albert, additional, Castañer, Olga, additional, Fitó, Montserrat, additional, Zomeño, María Dolores, additional, Pintó, Xavier, additional, Sacanella, Emilio, additional, Paz-Graniel, Indira, additional, and Salas-Salvadó, Jordi, additional

Published
2020
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50. Deficiencia de vitamina D en usuarios de atención primaria con riesgo en España.

Author

Díaz-López, Andrés, Paz-Graniel, Indira, Alonso-Sanz, Ramón, Marqués Baldero, Carolina, Mateos Gil, César, Arija, Victoria, and Arija Val, Victoria

Subjects
*CROSS-sectional method, *RETROSPECTIVE studies, *RISK assessment, *VITAMIN D, *PRIMARY health care, *VITAMIN D deficiency
Abstract

Introduction: Background and objectives: despite long hours of sunlight in Spain, vitamin D deficiency has been rising of late. We aimed to describe vitamin D deficiency and insufficiency in at-risk patients in La Rioja, a region in northern Spain. Methods: a retrospective, cross-sectional study involving 21,490 patients (74.3 % women) aged 14-105 years, who were primary health care (PHC) users in La Rioja, with an available 25-hidroxyvitamin D (25(OH)D) test result corresponding to the first request from January 2013 to October 2015. Vitamin D deficiency, insufficiency, and sufficiency were defined as 25(OH)D levels < 12 ng/mL, 12-20 ng/mL, and ≥ 20 ng/mL, respectively. Hypovitaminosis D was defined considering 2 cut-off points for 25(OH)D: < 20 ng/mL and < 30 ng/mL. Results: mean 25(OH)D levels were 18.3 (SD, 11.6) ng/mL in the whole sample, being lower in men than in women (17.6 vs 18.5 ng/mL, p < 0.001). Significantly higher 25(OH)D levels were found in the groups with 55-59, 60-64, 65-69, and 70-74 years of age (range, 19.4-20.4 ng/mL), and lower levels were found in the groups with 80-85 years and older (16.7 and 14.5 ng/mL), as compared to other groups. Two thirds of the population were vitamin D-deficient (< 12 ng/mL, 30.9 %) or insufficient (12-20 ng/mL, 32.8 %), and only 32.8 % of patients were found to be vitamin D-sufficient (> 20 ng/ml). Hypovitaminosis D rate was higher (89.7 %) when the 25(OH)D cut-off point was set at < 30 ng/mL. A higher hypovitaminosis D rate (< 20 ng/mL) was found in men (67.1 %) vs women (62.6 %) (p < 0.001), and it was more prevalent in patients over 75 years (72.6 %). The prevalence of hypovitaminosis D followed a seasonal pattern ranging from 51.8 % to 76.5 %; the lowest 25(OH)D levels were found in winter, and the highest in summer, with levels above 20 ng/mL in all age groups except for patients over 75 years (17.7 ng/mL). Patients over 75 years exhibited high rates of deficiency or insufficiency across all seasons of the year. Conclusions: in La Rioja, Spain, hypovitaminosis D was highly prevalent among PHC users, and especially in older age groups and during the winter months. [ABSTRACT FROM AUTHOR]

Published
2021
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