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3. Low frequency of genotypic resistance in HIV-1-infected patients failing an atazanavir-containing regimen: a clinical cohort study

Author

Dolling, David I, Dunn, David T, Sutherland, Katherine A, Pillay, Deenan, Mbisa, Jean L, Parry, Chris M, Post, Frank A, Sabin, Caroline A, Cane, Patricia A, Aitken, Celia, Asboe, David, Webster, Daniel, Cane, Patricia, Castro, Hannah, Dunn, David, Dolling, David, Chadwick, David, Churchill, Duncan, Clark, Duncan, Collins, Simon, Delpech, Valerie, Geretti, Anna Maria, Goldberg, David, Hale, Antony, Hué, Stéphane, Kaye, Steve, Kellam, Paul, Lazarus, Linda, Leigh-Brown, Andrew, Mackie, Nicola, Orkin, Chloe, Rice, Philip, Phillips, Andrew, Sabin, Caroline, Smit, Erasmus, Templeton, Kate, Tilston, Peter, Tong, William, Williams, Ian, Zhang, Hongyi, Zuckerman, Mark, Greatorex, Jane, Wildfire, Adrian, O'Shea, Siobhan, Mullen, Jane, Mbisa, Tamyo, Cox, Alison, Tandy, Richard, Hale, Tony, Fawcett, Tracy, Hopkins, Mark, Ashton, Lynn, Booth, Claire, Garcia-Diaz, Ana, Shepherd, Jill, Schmid, Matthias L, Payne, Brendan, Hay, Phillip, Rice, Phillip, Paynter, Mary, Bibby, David, Kirk, Stuart, MacLean, Alasdair, Gunson, Rory, Coughlin, Kate, Fearnhill, Esther, Fradette, Lorraine, Porter, Kholoud, Ainsworth, Jonathan, Anderson, Jane, Babiker, Abdel, Fisher, Martin, Gazzard, Brian, Gilson, Richard, Gompels, Mark, Hill, Teresa, Johnson, Margaret, Kegg, Stephen, Leen, Clifford, Nelson, Mark, Palfreeman, Adrian, Post, Frank, Sachikonye, Memory, Schwenk, Achim, Walsh, John, Huntington, Susie, Jose, Sophie, Thornton, Alicia, Glabay, Adam, Orkin, C, Garrett, N, Lynch, J, Hand, J, de Souza, C, Fisher, M, Perry, N, Tilbury, S, Gazzard, B, and Nelson, M

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Clinical Sciences, Clinical Trials and Supportive Activities, Infectious Diseases, Antimicrobial Resistance, Clinical Research, Infection, Adult, Anti-HIV Agents, Atazanavir Sulfate, Cohort Studies, Drug Resistance, Viral, Female, HIV Infections, HIV Protease, HIV-1, Humans, Male, Medication Adherence, Middle Aged, Mutation Rate, Mutation, Missense, Oligopeptides, Pyridines, Treatment Failure, United States, UK HIV Drug Resistance Database, UK Collaborative HIV Cohort Study, HIV, drug resistance mutations, naive patients, protease inhibitors, virological failure, Microbiology, Pharmacology and Pharmaceutical Sciences, Clinical sciences, Pharmacology and pharmaceutical sciences
Abstract

ObjectivesTo determine protease mutations that develop at viral failure for protease inhibitor (PI)-naive patients on a regimen containing the PI atazanavir.MethodsResistance tests on patients failing atazanavir, conducted as part of routine clinical care in a multicentre observational study, were randomly matched by subtype to resistance tests from PI-naive controls to account for natural polymorphisms. Mutations from the consensus B sequence across the protease region were analysed for association and defined using the IAS-USA 2011 classification list.ResultsFour hundred and five of 2528 (16%) patients failed therapy containing atazanavir as a first PI over a median (IQR) follow-up of 1.76 (0.84-3.15) years and 322 resistance tests were available for analysis. Recognized major atazanavir mutations were found in six atazanavir-experienced patients (P < 0.001), including I50L and N88S. The minor mutations most strongly associated with atazanavir experience were M36I, M46I, F53L, A71V, V82T and I85V (P < 0.05). Multiple novel mutations, I15S, L19T, K43T, L63P/V, K70Q, V77I and L89I/T/V, were also associated with atazanavir experience.ConclusionsViral failure on atazanavir-containing regimens was not common and major resistance mutations were rare, suggesting that adherence may be a major contributor to viral failure. Novel mutations were described that have not been previously documented.

Published
2013

6. A Fast Extraction-Free Isothermal LAMP Assay for Detection of SARS-CoV-2 in Resource-Limited Settings

Author

Gärtner, Kathleen, primary, Meleke, Harry, additional, Kamdolozi, Mercy, additional, Chaima, David, additional, Samikwa, Lyson, additional, Paynter, Mary, additional, Nyang'Wa, Maggie Nyirenda, additional, Cloutman-Green, Elaine, additional, Nastouli, Eleni, additional, Klein, Nigel, additional, Nyirenda, Tonney, additional, Msefula, Chisomo, additional, and Alber, Dagmar G., additional

Published
2022
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8. Family Economic Issues & Public Policy.

Author

Kentucky Univ., Lexington. Coll. of Home Economics., Kimsey, Peggy Poling, and Paynter, Mary Ann

Abstract

Emerging from two graduate seminars designed to increase the involvement of home economists in public policy, this publication includes course outlines, models, and papers on selected issues concerning family-related government policy. The structure and requirements of the two seminars, held in 1978 at the University of Kentucky, are described. A number of concerns which Kentucky home economists defined as the most important foci of their profession are listed, including: (1) education and media; (2) health, welfare and development of human capital; (3) family planning; (4) income and employment; (5) taxation; (6) housing; (7) energy resources; and (8) knowledge available to families. Models for increasing the political participation of home economists, for developing public policies related to families, and for evaluating family-related policy are presented. In addition, brief papers are included on the following issues: (1) government subsidization of programs to alleviate child abuse; (2) responsibility for financial support of children with divorced parents; (3) the use of Federal Medicaid funds for abortion; (4) the role of marital status in determining income taxes; (5) the encouragement of intentional communities; (6) the implications of energy conservation on industrial growth and family life; (7) Federal tax credits for energy-saving home improvements; and (8) mandatory retirement. Finally, seminar participants are listed and a bibliography of resources is provided. (GC)

Published
1979

10. A Concept of Charisms: Ordained Ministry in Religious Life

Author

Paynter, Mary

Subjects
A Concept of Charisms: Ordained Ministry in Religious Life (Book), Books -- Book reviews, Philosophy and religion
Abstract

At first glance, the subtitle of this collection of essays might suggest that its intended audience is limited to ordained (read: male) members of religious orders. That would be a [...]

Published
1998

11. The Unnecessary Problem of Edith Stein: Studies in the Shoah, vol 4

Author

Paynter, Mary

Subjects
The Unnecessary Problem of Edith Stein: Studies in the Shoah, Vol 4 (Book), Books -- Book reviews, Philosophy and religion
Abstract

The 'unnecessary problem' is not Edith Stein herself. The problem as defined by Harry Cargas in his introduction to this volume of essays is the church's decision to beatify her. [...]

Published
1995

12. POLTICAL EFFICACY AND POLITICAL PARTICIPATION OF FAMILY-ORIENTED PROFESSIONALS*.

Author

PAYNTER, MARY ANN and ALLEN, JACQUELINE WATTS

Abstract

Political activities of home economists were found to be markedly limited. Those who reported greater amounts of participation were characterized by strong feelings of political efficacy, backgrounds of family political involvement, greater amounts of community participation, and employment in colleges or universities. Respondents not presently employed, including students, homemakers and retired persons, appeared to be the least politically active group. Implications for the academic preparation of home economists are explored. [ABSTRACT FROM AUTHOR]

Published
1982
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13. Readers Report.

Author

Lindner, Camala A., Paynter, Mary Moree, Zeloof, Benjamin M., DeLuca, Karen Ann, Burns, Hazel D., Grosberbg, John, Sweet, Marilyn, Syring Jr., Edward M., and Arnold, Bill

Subjects
LETTERS to the editor, AIRLINE industry, HORMONE therapy
Abstract

Several letters to the editor are presented in response to articles in previous issues including "Bill Gates gets schooled," in the June 26, 2006 issue, "Satisfaction not guaranteed," in the June 19, 2006 issue, and "Homegrown hormone therapy," in the June 26, 2006 issue.

Published
2006

14. Low frequency of genotypic resistance in HIV-1-infected patients failing an atazanavir-containing regimen: a clinical cohort study

Author

Dolling, David I., Dunn, David T., Sutherland, Katherine A., Pillay, Deenan, Mbisa, Jean L., Parry, Chris M., Post, Frank A., Sabin, Caroline A., Cane, Patricia A., Aitken, Celia, Asboe, David, Webster, Daniel, Cane, Patricia, Castro, Hannah, Dunn, David, Dolling, David, Chadwick, David, Churchill, Duncan, Clark, Duncan, Collins, Simon, Delpech, Valerie, Geretti, Anna Maria, Goldberg, David, Hale, Antony, Hué, Stéphane, Kaye, Steve, Kellam, Paul, Lazarus, Linda, Leigh-Brown, Andrew, Mackie, Nicola, Orkin, Chloe, Rice, Philip, Phillips, Andrew, Sabin, Caroline, Smit, Erasmus, Templeton, Kate, Tilston, Peter, Tong, William, Williams, Ian, Zhang, Hongyi, Zuckerman, Mark, Greatorex, Jane, Wildfire, Adrian, O'Shea, Siobhan, Mullen, Jane, Mbisa, Tamyo, Cox, Alison, Tandy, Richard, Hale, Tony, Fawcett, Tracy, Hopkins, Mark, Ashton, Lynn, Booth, Claire, Garcia-Diaz, Ana, Shepherd, Jill, Schmid, Matthias L., Payne, Brendan, Hay, Phillip, Rice, Phillip, Paynter, Mary, Bibby, David, Kirk, Stuart, MacLean, Alasdair, Gunson, Rory, Coughlin, Kate, Fearnhill, Esther, Fradette, Lorraine, Porter, Kholoud, Ainsworth, Jonathan, Anderson, Jane, Babiker, Abdel, Fisher, Martin, Gazzard, Brian, Gilson, Richard, Gompels, Mark, Hill, Teresa, Johnson, Margaret, Kegg, Stephen, Leen, Clifford, Nelson, Mark, Palfreeman, Adrian, Post, Frank, Sachikonye, Memory, Schwenk, Achim, Walsh, John, Huntington, Susie, Jose, Sophie, Thornton, Alicia, Glabay, Adam, Orkin, C., Garrett, N., Lynch, J., Hand, J., de Souza, C., Fisher, M., Perry, N., Tilbury, S., Gazzard, B., Nelson, M., Waxman, M., Asboe, D., Mandalia, S., Delpech, V., Anderson, J., Munshi, S., Korat, H., Welch, J., Poulton, M., MacDonald, C., Gleisner, Z., Campbell, L., Gilson, R., Brima, N., Williams, I., Schwenk, A., Ainsworth, J., Wood, C., Miller, S., Johnson, M., Youle, M., Lampe, F., Smith, C., Grabowska, H., Chaloner, C., Puradiredja, D., Walsh, J., Weber, J., Ramzan, F., Mackie, N., Winston, A., Leen, C., Wilson, A., Allan, S., Palfreeman, A., Moore, A., and Wakeman, K.

Subjects
Male, Mutation rate, Pyridines, Human immunodeficiency virus (HIV), HIV Infections, medicine.disease_cause, THERAPY, Cohort Studies, 0302 clinical medicine, HIV Protease, Mutation Rate, 1108 Medical Microbiology, Genotype, Pharmacology (medical), 030212 general & internal medicine, Pharmacology & Pharmacy, Treatment Failure, drug resistance mutations, Original Research, 0303 health sciences, virological failure, UK Collaborative HIV Cohort Study (UK CHIC), Proteolytic enzymes, virus diseases, Middle Aged, 3. Good health, Infectious Diseases, Female, 1115 Pharmacology and Pharmaceutical Sciences, Life Sciences & Biomedicine, Oligopeptides, medicine.drug, Cohort study, 0605 Microbiology, Microbiology (medical), Adult, medicine.medical_specialty, Anti-HIV Agents, Atazanavir Sulfate, protease inhibitors, Mutation, Missense, RITONAVIR, Biology, Microbiology, Medication Adherence, 03 medical and health sciences, Internal medicine, SCORE, Drug Resistance, Viral, medicine, Humans, 030304 developmental biology, Pharmacology, Science & Technology, HIV, Virology, naive patients, United States, Atazanavir, Regimen, HIV-1, Ritonavir, UK HIV Drug Resistance Database (UKHDRD)
Abstract

Author(s): Dolling, David I; Dunn, David T; Sutherland, Katherine A; Pillay, Deenan; Mbisa, Jean L; Parry, Chris M; Post, Frank A; Sabin, Caroline A; Cane, Patricia A; UK HIV Drug Resistance Database (UKHDRD); UK Collaborative HIV Cohort Study (UK CHIC) | Abstract: ObjectivesTo determine protease mutations that develop at viral failure for protease inhibitor (PI)-naive patients on a regimen containing the PI atazanavir.MethodsResistance tests on patients failing atazanavir, conducted as part of routine clinical care in a multicentre observational study, were randomly matched by subtype to resistance tests from PI-naive controls to account for natural polymorphisms. Mutations from the consensus B sequence across the protease region were analysed for association and defined using the IAS-USA 2011 classification list.ResultsFour hundred and five of 2528 (16%) patients failed therapy containing atazanavir as a first PI over a median (IQR) follow-up of 1.76 (0.84-3.15) years and 322 resistance tests were available for analysis. Recognized major atazanavir mutations were found in six atazanavir-experienced patients (P l 0.001), including I50L and N88S. The minor mutations most strongly associated with atazanavir experience were M36I, M46I, F53L, A71V, V82T and I85V (P l 0.05). Multiple novel mutations, I15S, L19T, K43T, L63P/V, K70Q, V77I and L89I/T/V, were also associated with atazanavir experience.ConclusionsViral failure on atazanavir-containing regimens was not common and major resistance mutations were rare, suggesting that adherence may be a major contributor to viral failure. Novel mutations were described that have not been previously documented.

15. MOESM2 of Characterization of minority HIV-1 drug resistant variants in the United Kingdom following the verification of a deep sequencing-based HIV-1 genotyping and tropism assay

Author

Silver, Nicholas, Paynter, Mary, McAllister, Georgina, Atchley, Maureen, Sayir, Christine, Short, John, Winner, Dane, Alouani, David, Sharkey, Freddie, Bergefall, Kicki, Templeton, Kate, Carrington, David, and QuiĂąones-Mateu, Miguel

Subjects
health care economics and organizations, 3. Good health
Abstract

Additional file 2. Demographic, clinical and virological characteristics from NHS Lothianâ s patients.

16. MOESM1 of Characterization of minority HIV-1 drug resistant variants in the United Kingdom following the verification of a deep sequencing-based HIV-1 genotyping and tropism assay

Author

Silver, Nicholas, Paynter, Mary, McAllister, Georgina, Atchley, Maureen, Sayir, Christine, Short, John, Winner, Dane, Alouani, David, Sharkey, Freddie, Bergefall, Kicki, Templeton, Kate, Carrington, David, and QuiĂąones-Mateu, Miguel

Subjects
3. Good health
Abstract

Additional file 1: Table S1. Demographic, clinical and virological characteristics from St. Georgeâ s patients.

17. MOESM2 of Characterization of minority HIV-1 drug resistant variants in the United Kingdom following the verification of a deep sequencing-based HIV-1 genotyping and tropism assay

Author

Silver, Nicholas, Paynter, Mary, McAllister, Georgina, Atchley, Maureen, Sayir, Christine, Short, John, Winner, Dane, Alouani, David, Sharkey, Freddie, Bergefall, Kicki, Templeton, Kate, Carrington, David, and QuiĂąones-Mateu, Miguel

Subjects
health care economics and organizations, 3. Good health
Abstract

Additional file 2. Demographic, clinical and virological characteristics from NHS Lothianâ s patients.

18. MOESM1 of Characterization of minority HIV-1 drug resistant variants in the United Kingdom following the verification of a deep sequencing-based HIV-1 genotyping and tropism assay

Author

Silver, Nicholas, Paynter, Mary, McAllister, Georgina, Atchley, Maureen, Sayir, Christine, Short, John, Winner, Dane, Alouani, David, Sharkey, Freddie, Bergefall, Kicki, Templeton, Kate, Carrington, David, and QuiĂąones-Mateu, Miguel

Subjects
3. Good health
Abstract

Additional file 1: Table S1. Demographic, clinical and virological characteristics from St. Georgeâ s patients.

19. Uniqueness lost when parish ministry pushed.

Author

Paynter, Mary

Subjects
*CHURCH work, *RELIGIOUS life, *CLERGY
Abstract

Reviews the book `A Concert of Charisms: Ordained Ministry in Religious Life,' edited by Paul K. Hennessy.

Published
1998

20. Edith Stein is fine, but better not canonized.

Author

Paynter, Mary

Subjects
UNNECESSARY Problem of Edith Stein, The (Book)
Abstract

Reviews the book `The Unnecessary Problem of Edith Stein: Studies in the Shoah, Vol. IV,' edited by Harry James Cargas.

Published
1995

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