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Your search keyword '"Payne, Elspeth M."' showing total 34 results
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34 results on '"Payne, Elspeth M."'

2. Translation of cytoplasmic UBA1 contributes to VEXAS syndrome pathogenesis

Author

Ferrada, Marcela A., Savic, Sinisa, Cardona, Daniela Ospina, Collins, Jason C., Alessi, Hugh, Gutierrez-Rodrigues, Fernanda, Kumar, Dinesh Babu Uthaya, Wilson, Lorena, Goodspeed, Wendy, Topilow, James S., Paik, Julie J., Poulter, James A., Kermani, Tanaz A., Koster, Matthew J., Warrington, Kenneth J., Cargo, Catherine, Tattersall, Rachel S., Duncan, Christopher J.A., Cantor, Anna, Hoffmann, Patrycja, Payne, Elspeth M., Bonnekoh, Hanna, Krause, Karoline, Cowen, Edward W., Calvo, Katherine R., Patel, Bhavisha A., Ombrello, Amanda K., Kastner, Daniel L., Young, Neal S., Werner, Achim, Grayson, Peter C., and Beck, David B.

Published
2022
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7. The complex genetic landscape of familial MDS and AML reveals pathogenic germline variants

Author

Rio-Machin, Ana, Vulliamy, Tom, Hug, Nele, Walne, Amanda, Tawana, Kiran, Cardoso, Shirleny, Ellison, Alicia, Pontikos, Nikolas, Wang, Jun, Tummala, Hemanth, Al Seraihi, Ahad Fahad H., Alnajar, Jenna, Bewicke-Copley, Findlay, Armes, Hannah, Barnett, Michael, Bloor, Adrian, Bödör, Csaba, Bowen, David, Fenaux, Pierre, Green, Andrew, Hallahan, Andrew, Hjorth-Hansen, Henrik, Hossain, Upal, Killick, Sally, Lawson, Sarah, Layton, Mark, Male, Alison M., Marsh, Judith, Mehta, Priyanka, Mous, Rogier, Nomdedéu, Josep F., Owen, Carolyn, Pavlu, Jiri, Payne, Elspeth M., Protheroe, Rachel E., Preudhomme, Claude, Pujol-Moix, Nuria, Renneville, Aline, Russell, Nigel, Saggar, Anand, Sciuccati, Gabriela, Taussig, David, Toze, Cynthia L., Uyttebroeck, Anne, Vandenberghe, Peter, Schlegelberger, Brigitte, Ripperger, Tim, Steinemann, Doris, Wu, John, Mason, Joanne, Page, Paula, Akiki, Susanna, Reay, Kim, Cavenagh, Jamie D., Plagnol, Vincent, Caceres, Javier F., Fitzgibbon, Jude, and Dokal, Inderjeet

Published
2020
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16. British Society for Haematology guidelines for the management of adult myelodysplastic syndromes

Author

Killick, Sally B., primary, Ingram, Wendy, additional, Culligan, Dominic, additional, Enright, Helen, additional, Kell, Jonathan, additional, Payne, Elspeth M., additional, Krishnamurthy, Pramila, additional, Kulasekararaj, Austin, additional, Raghavan, Manoj, additional, Stanworth, Simon J., additional, Green, Simone, additional, Mufti, Ghulam, additional, Quek, Lynn, additional, Cargo, Catherine, additional, Jones, Gail L., additional, Mills, Juliet, additional, Sternberg, Alex, additional, Wiseman, Daniel H., additional, and Bowen, David, additional

Published
2021
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17. TLR7 ligation augments haematopoiesis in Rps14 (uS11) deficiency via paradoxical suppression of inflammatory signalling and enhanced differentiation

Author

Peña, Oscar A, primary, Lubin, Alexandra, additional, Rowell, Jasmine, additional, Hockings, Catherine, additional, Jung, Youngrock, additional, Hoade, Yvette, additional, Dace, Phoebe, additional, Valdivia, Leonardo E, additional, Tuschl, Karin, additional, Boiers, Charlotta, additional, Virgilio, Maria C, additional, Richardson, Simon, additional, and Payne, Elspeth M, additional

Published
2020
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20. British Society for Haematology guidelines for the diagnosis and evaluation of prognosis of Adult Myelodysplastic Syndromes.

Author

Killick, Sally B., Wiseman, Daniel H., Quek, Lynn, Cargo, Catherine, Culligan, Dominic, Enright, Helen, Green, Simone, Ingram, Wendy, Jones, Gail L., Kell, Jonathan, Krishnamurthy, Pramila, Kulasekararaj, Austin, Mills, Juliet, Mufti, Ghulam, Payne, Elspeth M., Raghavan, Manoj, Stanworth, Simon J., Sternberg, Alex, and Bowen, David

Subjects
MYELODYSPLASTIC syndromes, DIAGNOSIS, PROGNOSIS, HEMATOLOGY, PAROXYSMAL hemoglobinuria, PANCYTOPENIA, MEDICAL personnel
Abstract

Keywords: myelodysplastic syndromes; MDS; guideline; diagnosis EN myelodysplastic syndromes MDS guideline diagnosis 282 293 12 07/19/21 20210715 NES 210715 Scope This document represents an update of the British Society of Haematology guideline published in 2014 due to advances in understanding the biology and therapy of the myelodysplastic syndromes (MDS).1 The objective of these guidelines is to provide healthcare professionals with clear guidance on the diagnosis and evaluation of prognosis of adult patients with MDS. Trephine section histology is especially helpful for the diagnosis of hypocellular MDS and MDS/myeloproliferative neoplasms (MPN) overlap syndromes.9 Patients with MDS/MPN overlap including CMML are now considered a distinct entity by the WHO when features of both MDS and MPN are present. Patients and family members should ideally be offered genetic counselling before genetic screening if there is a high clinical suspicion.42 Recommendations Myelodysplastic Syndromes (MDS) should be suspected in patients with otherwise unexplained cytopenias(s) or macrocytosis (1A). In the context of persistent and otherwise unexplained cytopenias, a WHO-defined diagnosis of MDS requires either (i) morphological dysplasia (involving >=10% of bone marrow cells in >=1 lineage); (ii) increased myeloblasts (>=5%, but <20%); or (iii) evidence of clonality with a typical MDS-associated cytogenetic abnormality.2,4 Dysplasia is not restricted to MDS patients and can occur following a toxic insult, in reactive conditions or secondary to haematinic deficiencies. [Extracted from the article]

Published
2021
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24. Clinical outcomes and survival of patients with myeloma and lymphoma enrolled into phase I clinical trials.

Author

El‐Sharkawi, Dima, Ng, Chin‐Hin, Payne, Elspeth M., Yong, Kwee L., Ardeshna, Kirit M., Khwaja, Asim, Townsend, William, and Popat, Rakesh

Subjects
CLINICAL trials, LYMPHOMAS, MELPHALAN, ALBUMINS
Abstract

The article offers information on the patients outcomes with haematological malignancies treated in phase 1 trials at a large specialist haematology centre. It mentions the survival of patients with myeloma and lymphoma enrolled onto early phase trials were better; and also mentions a significant number of patients were able to receive further treatment, including other clinical trials.

Published
2019
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29. Myelopoiesis and Myeloid Leukaemogenesis in the Zebrafish

Author

Forrester, A. Michael, Berman, Jason N., and Payne, Elspeth M.

Subjects
Article Subject
Abstract

Over the past ten years, studies using the zebrafish model have contributed to our understanding of vertebrate haematopoiesis, myelopoiesis, and myeloid leukaemogenesis. Novel insights into the conservation of haematopoietic lineages and improvements in our capacity to identify, isolate, and culture such haematopoietic cells continue to enhance our ability to use this simple organism to address disease biology. Coupled with the strengths of the zebrafish embryo to dissect developmental myelopoiesis and the continually expanding repertoire of models of myeloid malignancies, this versatile organism has established its niche as a valuable tool to address key questions in the field of myelopoiesis and myeloid leukaemogenesis. In this paper, we address the recent advances and future directions in the field of myelopoiesis and leukaemogenesis using the zebrafish system.

Published
2012
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31. Endothelial Von Willebrand factor regulates angiogenesis

Author

Starke, Richard D., primary, Paschalaki, Koralia E., additional, Ferraro, Francesco, additional, Dryden, Nicola H., additional, McKinnon, Thomas A.J., additional, Sutton, Rachel E., additional, Payne, Elspeth M., additional, Haskard, Dorian O., additional, Hughes, Alun D., additional, Cutler, Daniel F., additional, Laffan, Mike A., additional, and Randi, Anna M., additional

Published
2012
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34. cpsf1is required for definitive HSC survival in zebrafish

Author

Bolli, Niccolò, Payne, Elspeth M., Rhodes, Jennifer, Gjini, Evisa, Johnston, Adam B., Guo, Feng, Lee, Jeong-Soo, Stewart, Rodney A., Kanki, John P., Chen, Aye T., Zhou, Yi, Zon, Leonard I., and Look, A. Thomas

Abstract

A comprehensive understanding of the genes and pathways regulating hematopoiesis is needed to identify genes causally related to bone marrow failure syndromes, myelodysplastic syndromes, and hematopoietic neoplasms. To identify novel genes involved in hematopoiesis, we performed an ethyl-nitrosourea mutagenesis screen in zebrafish (Danio rerio) to search for mutants with defective definitive hematopoiesis. We report the recovery and analysis of the grechettomutant, which harbors an inactivating mutation in cleavage and polyadenylation specificity factor 1(cpsf1), a gene ubiquitously expressed and required for 3′ untranslated region processing of a subset of pre-mRNAs. grechettomutants undergo normal primitive hematopoiesis and specify appropriate numbers of definitive HSCs at 36 hours postfertilization. However, when HSCs migrate to the caudal hematopoietic tissue at 3 days postfertilization, their numbers start decreasing as a result of apoptotic cell death. Consistent with Cpsf1 function, c-myb:EGFP+cells in grechettomutants also show defective polyadenylation of snrnp70, a gene required for HSC development. By 5 days postfertilization, definitive hematopoiesis is compromised and severely decreased blood cell numbers are observed across the myeloid, erythroid, and lymphoid cell lineages. These studies show that cpsf1is essential for HSC survival and differentiation in caudal hematopoietic tissue.

Published
2011
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