1. IL-6, IL-10 and TNF-α gene polymorphisms in preeclampsia: a case-control study in a Mexican population.
- Author
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Mora Palazuelos, Carlos Ernesto, Aguilar Medina, Elsa Maribel, Avendaño Felix, Mariana Melisa, Payan, Rosalio Ramos, Bermudez Cortes, Mercedes, Lara Avila, Leticia, Salazar, Adrian Herrera, Murillo Llanes, Joel, Sanchez-Schmitz, Guzman, and Romero Quintana, Jose Geovanni
- Subjects
GENOTYPES ,TUMOR necrosis factor receptors ,GENETIC polymorphisms ,PREECLAMPSIA ,PREGNANT women - Abstract
Objectives: We focused our study on examining the genotype and allele frequency of IL-6 (rs1800795), TNF-α (rs1800629) and IL-10 (rs1800872) single nucleotide polymorphisms (SNP) on preeclampsia (PE) diagnosed Mexican pregnant women. Material and methods: A case-control study was designed including 86 preeclampsia patients and 100 normotensives pregnancies from Women’s Hospital of Culiacan, Mexico. Genotyping of IL-6, TNF-α and IL-10 was performed using TaqMan SNP Genotyping. Results: Not significant association was found between development of PE and genotypic (p > 0.05) and allelic (p > 0.05) frequencies of IL-6, TNF-α and IL-10 SNPs. Genotype distributions of IL-6 (p = 0.599), TNF-α (p = 0.721) and IL-10 (p = 0.761) polymorphisms in the two groups were in agreement with Hardy–Weinberg equilibrium. Conclusions: According to the findings, the IL-6, TNF-α and IL-10 SNPs are not exponents of susceptibility to developing PE. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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