Search

Your search keyword '"Payam Farahbakhsh-Farsi"' showing total 6 results
Start Over Author "Payam Farahbakhsh-Farsi"
6 results on '"Payam Farahbakhsh-Farsi"'

1. Lipid peroxidation and antioxidant enzymes activity in controlled and uncontrolled Type 2 diabetic patients

Author

Mahnaz Zarei, Zahra Farahnak, Mohammad Javad Hosseinzadeh-Attar, Mohammad Hassan Javanbakht, Payam Hosseinzadeh, Hoda Derakhshanian, Payam Farahbakhsh-Farsi, and Mahmoud Djalali

Subjects
Antioxidant, Lipid Peroxidation, Diabetes Mellitus, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

BACKGROUND: This study was designed to compare lipid peroxidation and antioxidant enzymes activity in Type 2 diabetes patients with good or weak glycemic control. METHODS: In this case-control study, 62 Type 2 diabetic patients with glycated hemoglobin (HbA1c) between 6 and 8 were enrolled as the controlled group and 55 patients with HbA1c > 8 were selected as an uncontrolled group. Patients were all referred to Iranian Diabetes Association in Tehran, Iran, from 2010 onward. Groups were chosen by convenience sampling and were matched based on age, sex and duration of disease. Demographic questionnaire, two 24-hour food recall, HbA1c, insulin, malondialdehyde (MDA), superoxide dismutase (SOD), and catalase were measured in blood samples. Data were analyzed by Food Processor II and SPSS software. RESULTS: A mean daily consumption of energy, carbohydrate, protein, and fat was not significantly different between two groups. MDA in the uncontrolled group was significantly higher than controlled group (2.03 ± 0.88 vs. 1.65 ± 1.01 nmol/ml; P = 0.030). A mean SOD was slightly higher in the uncontrolled group comparing to the control group (843.3 ± 101.9 vs. 828.0 ± 127.3 U/g Hb; P = 0.400). CONCLUSION: These data suggest that MDA as a lipid peroxidation indicator is higher in uncontrolled diabetes probably due to chronic high blood sugar followed by higher oxidative stress.

Published
2016

2. Effect of Omega-3 Supplementation on Lipocalin 2 and Retinol-Binding Protein 4 in Type 2 Diabetic Patients

Author

Payam FARAHBAKHSH-FARSI, Abolghassem DJAZAYERY, Mohammad Reza ESHRAGHIAN, Fariba KOOHDANI, Mahnaz ZAREI, Mohammad Hassan JA­VANBAKHT, Hoda DERAKHSHANIAN, and Mahmoud DJALALI

Subjects
Public aspects of medicine, RA1-1270
Abstract

Background: Serum levels of lipocalin 2 (LCN 2) and retinol-binding protein-4 (RBP 4), increase in type 2 diabetes mellitus (T2DM). We sought to determine whether serum LCN 2 and RBP 4 change after an intervention with omega-3 fatty acids supplementation in diabetic patients.Methods: Forty-five type 2 diabetic patients from Iranian Diabetic Association in Tehran, Iran in 2013 were randomly recruited into two groups: one group received 4 g/d omega-3 for 10 wk; and the control group received placebo. Blood samples, food intake records, anthropometric measurements were obtained from all participants at the beginning and end of the study.Results: Fasting RBP 4 plasma levels significantly changed after 10 wk supplementation (P = 0.01). The LCN 2 concentrations decreased in omega-3 group, but the changes were not statistically significant. Omega-3 supplementation had no noticeable effect on anthropometric factors.Conclusions: These findings provide a rationale for omega-3 supplements aimed at lowering serum RBP 4 levels in T2DM. Keywords: Omega-3 fatty acid, Lipocalin, Retinol-binding protein, Diabetes mellitus

Published
2016

3. Effects of vitamin A, C and E, or omega-3 fatty acid supplementation on the level of paraoxonase and arylesterase activity in streptozotocin-induced diabetic rats: an investigation of activities in plasma, and heart and liver homogenates

Author

Mahnaz Zarei, Payam Farahbakhsh-Farsi, Ebrahim Mostafavi, Seyed Mohammad Bagher Tabei, Mohammad Hassan Javanbakht, Mohammad Reza Sadeghi, Hoda Derakhshanian, Mahmoud Djalali, and Shima Fakher

Subjects
Male, 0301 basic medicine, Vitamin, medicine.medical_specialty, medicine.medical_treatment, Ascorbic Acid, Diabetes Mellitus, Experimental, Rats, Sprague-Dawley, Arylesterase, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, Fatty Acids, Omega-3, medicine, Animals, Vitamin A, Omega 3 fatty acid, chemistry.chemical_classification, Vitamin C, biology, Aryldialkylphosphatase, business.industry, Myocardium, Vitamin E, Paraoxonase, Fatty acid, Vitamins, General Medicine, Ascorbic acid, Rats, 030104 developmental biology, Endocrinology, Liver, chemistry, 030220 oncology & carcinogenesis, Dietary Supplements, biology.protein, Original Article, business, Carboxylic Ester Hydrolases
Abstract

INTRODUCTION This study was designed and conducted to evaluate the effects of vitamin A, C and E supplementation, and omega-3 fatty acid supplementation on the activity of paraoxonase and arylesterase in an experimental model of diabetes mellitus. METHODS A total of 64 male Sprague Dawley® rats, each weighing 250 g, were randomly distributed into four groups: (a) normal control; (b) diabetic control; (c) diabetic with vitamin A, C and E supplementation; and (d) diabetic with omega-3 fatty acid supplementation. The animals were anaesthetised after four weeks of intervention, and paraoxonase and arylesterase activity in blood plasma, and liver and heart homogenates were measured. RESULTS Arylesterase activity in the heart and liver homogenates was significantly lower in the diabetic control group than in the normal control group (p < 0.01). Vitamin A, C and E supplementation, and omega-3 fatty acid supplementation significantly increased liver arylesterase activity (p < 0.05). No significant change was observed in paraoxonase activity and other investigated factors. CONCLUSION Vitamin A, C and E, or omega-3 fatty acid supplementation were found to increase liver arylesterase activity in streptozotocin-induced diabetic rats. These supplements may be potential agents for the treatment of diabetes mellitus complications.

Published
2016

4. Effects of supplementation with omega-3 on insulin sensitivity and non-esterified free fatty acid (NEFA) in type 2 diabetic patients

Author

Payam Farahbakhsh Farsi, Ali Akbar Saboor-Yaraghi, Fariba Koohdani, Mahmoud Djalali, Mohammad Reza Eshraghian, Hoda Derakhshanian, Abolghassem Djazayery, Mohammad Hassan Javanbakht, and Mahnaz Zarei

Subjects
Blood Glucose, Male, ácidos graxos ômega-3, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Fatty Acids, Nonesterified, law.invention, Body Mass Index, chemistry.chemical_compound, Randomized controlled trial, law, Insulin, chemistry.chemical_classification, Glucose tolerance test, medicine.diagnostic_test, omega-3 fatty acids, General Medicine, Middle Aged, diabetes mellitus, Female, Waist Circumference, Adult, medicine.medical_specialty, insulin, Ácidos graxos não esterificados, Placebo, diabetes melito, NEFA, Double-Blind Method, Internal medicine, Diabetes mellitus, Fatty Acids, Omega-3, medicine, Dietary Carbohydrates, Humans, insulina, Triglycerides, Analysis of Variance, business.industry, Cholesterol, Cholesterol, HDL, Fatty acid, Cholesterol, LDL, Glucose Tolerance Test, medicine.disease, Lipid Metabolism, Endocrinology, chemistry, Diabetes Mellitus, Type 2, Dietary Supplements, Insulin Resistance, business, Non-esterified fatty acids
Abstract

Objective: The aim of this study was to determine the role of omega-3 supplementation on NEFA concentration, insulin sensitivity and resistance, and glucose and lipid metabolism in type 2 diabetic patients. Subjects and methods: Forty-four type 2 diabetic patients were randomly recruited into two groups. Group A received 4 g/day omega-3 soft gels, and group B received a placebo for 10 wks. Blood samples were collected after 12-h fast. Physical activity records, three-day food records, and anthropometric measurements were obtained from all participants at the beginning and end of the study. Results: Omega-3 supplementation caused a significant reduction in NEFA in the intervention group compared with the placebo group (P = 0.009). Additionally, the administration of omega-3 resulted in significantly greater changes (Diff) for the intervention group in various parameters, such as insulin and Quicki indices compared with the placebo group (P < 0.05). Conclusions: Omega-3 fatty acid supplementation in type 2 diabetic patients improved insulin sensitivity, probably due to the decrease in NEFA concentrations. Arq Bras Endocrinol Metab. 2014;58(4):335-40 Objetivo: O objetivo deste estudo foi analisar o papel da suplementação com ácidos graxos ômega-3 sobre a concentração de ácidos graxos não esterificados (AGNE), resistência e sensibilidade à insulina e metabolismo de lipídios em pacientes com diabetes melito tipo 2. Sujeitos e métodos: Quarenta e quatro pacientes com diabetes tipo 2 foram recrutados aleatoriamente e alocados em um de dois grupos. O Grupo A recebeu 4 g/dia de ômega-3 na forma de cápsulas gelatinosas e o grupo B recebeu placebo durante 10 semanas. Amostras de sangue foram coletadas após 12 horas de jejum. Registros da atividade física, da dieta de três dias e medidas antropométricas foram obtidos de todos os participantes no início e no final do estudo. Resultados: A suplementação com ômega-3 causou uma redução significativa na AGNE em comparação com grupo placebo (P = 0,008). Além disso, a administração de ômega-3 resultou em alterações significativamente maiores (Dif) em vários parâmetros, tais como a insulina, HOMA-IR e QUICKI, comparando com placebo (P < 0,05). Conclusões: A suplementação com ácidos graxos ômega-3 em pacientes diabéticos tipo 2 melhorou a sensibilidade à insulina, provavelmente devido à diminuição da concentração de AGNE. Arq Bras Endocrinol Metab. 2014;58(4):335-40

Published
2014

5. Effects of vitamin A, C and E, or omega-3 fatty acid supplementation on the level of paraoxonase and arylesterase activity in streptozotocin-induced diabetic rats: an investigation of activities in plasma, and heart and liver homogenates.

Author

Zarei, Mahnaz, Fakher, Shima, Seyed Mohammad Bagher Tabei, Mohammad Hassan Javanbakht, Hoda Derakhshanian, Payam Farahbakhsh-Farsi, Mohammad Reza Sadeghi, Ebrahim Mostafavi, Mahmoud Djalali, Tabei, Seyed Mohammad Bagher, Javanbakht, Mohammad Hassan, Derakhshanian, Hoda, Farahbakhsh-Farsi, Payam, Sadeghi, Mohammad Reza, Mostafavi, Ebrahim, and Djalali, Mahmoud

Subjects
PARAOXONASE, TREATMENT of diabetes, DIABETES complications, OMEGA-3 fatty acids, LABORATORY rats, VITAMIN A, VITAMIN C, VITAMIN E, DIET therapy for diabetes, ANIMAL experimentation, COMPARATIVE studies, DIABETES, DIETARY supplements, ESTERASES, LIVER, RESEARCH methodology, MEDICAL cooperation, MYOCARDIUM, RATS, RESEARCH, VITAMINS, EVALUATION research
Abstract

Introduction: This study was designed and conducted to evaluate the effects of vitamin A, C and E supplementation, and omega-3 fatty acid supplementation on the activity of paraoxonase and arylesterase in an experimental model of diabetes mellitus.Methods: A total of 64 male Sprague Dawley® rats, each weighing 250 g, were randomly distributed into four groups: (a) normal control; (b) diabetic control; (c) diabetic with vitamin A, C and E supplementation; and (d) diabetic with omega-3 fatty acid supplementation. The animals were anaesthetised after four weeks of intervention, and paraoxonase and arylesterase activity in blood plasma, and liver and heart homogenates were measured.Results: Arylesterase activity in the heart and liver homogenates was significantly lower in the diabetic control group than in the normal control group (p < 0.01). Vitamin A, C and E supplementation, and omega-3 fatty acid supplementation significantly increased liver arylesterase activity (p < 0.05). No significant change was observed in paraoxonase activity and other investigated factors.Conclusion: Vitamin A, C and E, or omega-3 fatty acid supplementation were found to increase liver arylesterase activity in streptozotocin-induced diabetic rats. These supplements may be potential agents for the treatment of diabetes mellitus complications. [ABSTRACT FROM AUTHOR]

Published
2016
Full Text
View/download PDF

6. Effect of omega-3 supplementation versus placebo on acylation stimulating protein receptor gene expression in type 2 diabetics

Author

Maryam Chamari, Mahmoud Djalali, Mohammad Hassan Javanbakht, Abolghassem Djazayery, Ali Akbar Saboor-Yaraghi, Mohammad Reza Eshraghian, Payam Farahbakhsh-Farsi, and Fariba Koohdani

Subjects
Omega-3, medicine.medical_specialty, business.industry, Endocrinology, Diabetes and Metabolism, Type 2 Diabetes Mellitus, medicine.disease, Placebo, Mean difference, law.invention, Acylation stimulating protein, Endocrinology, Randomized controlled trial, law, Diabetes mellitus, Internal medicine, Gene expression, Type 2 diabetes mellitus, Internal Medicine, Medicine, business, Receptor, Acylation stimulating protein receptor (C5L2), Research Article
Abstract

Background This randomized controlled trial investigated the role of omega-3 supplementation on C5L2 gene expression in type 2 diabetics. Methods Subjects in the omega-3 group received 4 g omega-3 per day and subjects in the placebo group took four capsules of placebo per day for 10 weeks. Gene expression was measured by RT- PCR at the beginning and end of the study. Results The results of this study show depletion in the omega-3 group, but the mean difference between two groups was not significant. Conclusions Understanding the effect of the omega-3 pathway could contribute to targeting treatment of diabetes and its comorbidities.

Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results