Search

Your search keyword '"Payab, Meghdad"' showing total 7 results
Start Over Author "Payab, Meghdad"
7 results on '"Payab, Meghdad"'

1. Development and validation of a short runtime method for separation of trace amounts of 4-aminophenol, phenol, 3-nitrosalicylic acid and mesalamine by using HPLC system

Author

Siadati, Seyyed Amir, Rezvanfar, Mohammad Amin, Payab, Meghdad, and Beheshti, Abolghasem

Subjects
Chemistry, QD1-999
Abstract

In a short runtime process (about 6 minutes), with isocratic method without need of reconditioning before the next run, a mixture of some molecules containing 4-aminophenol (4APh), phenol, 3-nitrosalicylic acid (3NSA), and mesalamine (5-aminosalicylic acid) (MLZ), were separated and detected by means of HPLC/UV-Vis system. The resolutions of the separated and sharp peaks referring to the mentioned compounds were at least more than 2, and the tailing factor (TF) was about 1, even in 1 µg/l (ppm) concentration. In order to optimize the method, the effects of the pH, eluent percentage, flow rate, and buffer concentration, and wavelength on the chromatogram were investigated. Also, the results of the validation processes showed that the method trustable to be used in laboratories.

Published
2021
Full Text
View/download PDF

7. An Industrial Approach to Production of Tofacitinib Citrate (TFC) as an Anti-COVID-19 Agent: A Joint Experimental and Theoretical Study

Author

Amir Siadati, Seyyed, Soheilizad, Mehdi, Firoozpour, Loghman, Samadi, Marjan, Payab, Meghdad, Bagherpour, Saeed, and Mehdi Mousavi, Seyyed

Abstract

In this report, we have presented our experience about a facile method for synthesis of tofacitinib citrate (TFC). The developed analytical methods for identification and qualifications are also included. As TFC seems to be effective in treatment of the symptoms of COVID-19 (SARS family), manufacturing of this active pharmaceutical ingredient (API) could be helpful. The API of TFC was prepared from the diamine intermediate in an ambient and solvent-free condition. Elimination of the reaction solvent resulted in decreasing the cost and preventing the rejection of the organic volatile impurity (OVI) test. The final citrate addition step was carried out using water as a solvent (the citrate content was 37.5% by potentiometry). Moreover, the results of the Karl-Fischer (KF) titration analysis was about 0.24%, which showed that the use of water does not increase the water content of the crystal structure.

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results