1. Cost-effectiveness analysis of probiotic peanut oral immunotherapy (PPOIT) versus placebo in Australian children with peanut allergy alongside a randomised trial
- Author
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Li Huang, Mimi Tang, Kim Dalziel, Melanie Lloyd, Paxton Loke, and Adriana C Lozinsky
- Subjects
Medicine - Abstract
Objective To compared the cost-effectiveness of coadministration of a probiotic adjuvant with peanut oral immunotherapy (PPOIT) with placebo (no treatment) in children with peanut allergy.Design Prospectively planned cost-effectiveness analysis alongside a randomised control trial.Setting The Royal Children’s Hospital, Melbourne, Australia.Participants 56 children with peanut allergy aged 1–10 years at recruitment.Intervention A daily dose of probiotic Lactobacillus rhamnosus CGMCC 1.3724 (NCC4007) and peanut oral immunotherapy administered for 1.5 years.Main outcomes measures Costs were considered from a healthcare system perspective and included costs of treatment delivery and adverse events. Effectiveness outcomes included rate of sustained unresponsiveness (SU) and quality-adjusted life years (QALYs). The cost-effectiveness of PPOIT versus placebo was analysed using patient-level data. Time horizon was 10 years from commencement of PPOIT treatment, comprising 1.5 years of treatment (actual data), 4 years of post-treatment follow-up (actual data), and 4.5 years of extrapolation thereafter (modelling).Results Healthcare cost per patient over 10 years was higher for PPOIT compared with placebo ($A9355 vs $A1031, p
- Published
- 2023
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