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5. Automatic Segmentation of Neurons in 3D Samples of Human Brain Cortex

Author

Mazzamuto, G., Costantini, I., Neri, M., Roffilli, M., Silvestri, L., Pavone, F. S., Hutchison, David, Series Editor, Kanade, Takeo, Series Editor, Kittler, Josef, Series Editor, Kleinberg, Jon M., Series Editor, Mattern, Friedemann, Series Editor, Mitchell, John C., Series Editor, Naor, Moni, Series Editor, Pandu Rangan, C., Series Editor, Steffen, Bernhard, Series Editor, Terzopoulos, Demetri, Series Editor, Tygar, Doug, Series Editor, Weikum, Gerhard, Series Editor, Sim, Kevin, editor, and Kaufmann, Paul, editor

Published
2018
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8. Efficient magneto-optical trapping of a metastable helium gas

Author

Santos, F. Pereira Dos, Perales, F., Leonard, J., Sinatra, A., Wang, Junmin, Pavone, F. S., Rasel, E., Unnikrishnan, C. S., and Leduc, M.

Subjects
Physics - Atomic Physics
Abstract

This article presents a new experiment aiming at BEC of metastable helium atoms. It describes the design of a high flux discharge source of atoms and a robust laser system using a DBR diode coupled with a high power Yb doped fiber amplifier for manipulating the beam of metastable atoms. The atoms are trapped in a small quartz cell in an extreme high vacuum. The trapping design uses an additional laser (repumper) and allows the capture of a large number of metastable helium atoms (approximately $10^9$) in a geometry favorable for loading a tight magnetostatic trap., Comment: 12 pages, 7 figures, LateX

Published
2001
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9. Penning collisions of laser-cooled metastable helium atoms

Author

Santos, F. Pereira Dos, Perales, F., Leonard, J., Sinatra, A., Wang, Junmin, Pavone, F. S., Rasel, E., Unnikrishnan, C. S., and Leduc, M.

Subjects
Physics - Atomic Physics
Abstract

We present experimental results on the two-body loss rates in a magneto-optical trap of metastable helium atoms. Absolute rates are measured in a systematic way for several laser detunings ranging from -5 to -30 MHz and at different intensities, by monitoring the decay of the trap fluorescence. The dependence of the two-body loss rate coefficient $\beta$ on the excited state ($2^3P_2$) and metastable state ($2^3S_1$) populations is also investigated. From these results we infer a rather uniform rate constant $K_{sp}=(1{\pm}0.4)\times10^{-7}$ cm$^3$/s., Comment: 8 pages, 9 figures, Revtex

Published
2001
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13. Cobrawap: a modular cortical wave analysis pipeline for heterogeneous data

Author

Gutzen, R., Bonis, G. D., Grün, S., Davison, A., Paolucci, P. S., Denker, M., Pastorelli, E., Capone, C., Luca, C. D., Mascaro, A. L. A., Resta, F., Pavone, F. S., Sanchez-Vives, M. V., and Mattia, M.

Abstract

Introduction:An unprecedented richness of data and methodologies enables more detailed access to neural processes but also poses the challenge to combine insights across experiments, species, and measurement techniques. While different experimental recording modalities offer complementary views onto the brain, their data analysis approaches and workflows are often too specific to compare the results rigorously. However, this challenge also promises new avenues of scientific progress. By aligning existing data and analyses from different sources in a reusable workflow we can build a broader basis for meta-studies, contextualization of individual studies, and model validation.Here, we showcase such an analysis pipeline with the application to cortical wave activity in the delta (‘slow waves’) and beta range. Cortical waves can be prominently observed in a variety of heterogeneous data [1,2] and a plethora of analytical methods exist that we aim to interface within a consistent framework: the ‘collaborative brain wave analysis pipeline’ (CobraWap).Methods:The design of CobraWap is based on modular building blocks that provide implementations of analysis methods and processing steps. These blocks are grouped in task-specific stages, e.g., data entry, data processing, trigger detection, wave detection, wave characterization. By letting the pipeline match the input and output format requirements for each of these pipeline components, defining a workflow becomes a matter of selecting a combination of stages and blocks to be applied. This flexibility is employed to converge the heterogeneous data to a common description level of wave activity, from which then common characteristic measures, such as velocity, direction, inter-wave intervals, or wave type classifications, can be derived and quantitatively compared across the data. We demonstrate the versatility of the pipeline with multiple datasets of ECoG [3] and calcium imaging recordings [4] of anesthetized mice, and Utah-array recordings of awake behaving macaques [e.g. 5]. Further, we integrate standard analysis methods from the literature to serve the requirements of a wide range of datasets and research questions. To emphasize the reusability and extendability of each of the pipeline components, the pipeline builds entirely on open-source solutions, such as the workflow manager Snakemake (RRID:SCR_003475), the Neo (RRID:SCR_000634) library for data representation [6], the Elephant (RRID:SCR_003833) analysis toolbox, and the EBRAINS Knowledge Graph (https://kg.ebrains.eu) for capturing outputs of the pipeline execution.Results:The pipeline design promotes the creation of application-tailored and reproducible analysis workflows for many datasets. We demonstrate this “big-data'' approach by investigating dataset-specific parameters across different experiments. For example, we evaluate the influences of the type and dose of anesthesia or the measurement modality and their temporal and spatial resolution on the characteristics of slow waves (e.g., wave velocities) and show that we can replicate corresponding findings from the literature [7,8,9,10].Just as applying the same methods to different data enables a fair comparison between datasets, the pipeline equally enables analyzing the same data with different methods to benchmark their influence on the resulting wave detection and characterization. Finally, we adapt the pipeline for the analysis of beta waves and discuss how the individual elements can be reused, rearranged, or extended to help derive analysis workflows for similar research endeavors and amplify collaborative research.Conclusions:While there are growing efforts in formalizing how neuroscientific data is represented and stored, we here present the benefits of furthermore formalizing the analysis workflows, leveraging the benefits of the diversity in data and methods towards easier collaboration and a cumulative understanding of brain function. REFERENCES[1] Adamantidis, A. R., Herrera C. G., and Gent T. C. (2019) "Oscillating circuitries in the sleeping brain." Nature Reviews Neuroscience 1-17. doi: 10.1038/s41583-019-0223-4[2] Muller, L. et al. (2018). “Cortical Travelling Waves: Mechanisms and Computational Principles.” Nature Reviews Neuroscience 19 (5): 255–68. doi: 10.1038/nrn.2018.20.[3] Sanchez-Vives, M. (2019) “Cortical activity features in transgenic mouse models of cognitive deficits (Williams Beuren Syndrome)” [Data set]. EBRAINS. doi: 10.25493/DZWT-1T8; Sanchez-Vives, M. (2019) "Cortical activity features in transgenic mouse models of cognitive deficits (Williams Beuren Syndrome)" EBRAINS. doi: 10.25493/ANF9-EG3[4] Resta, F., Allegra Mascaro, A. L., & Pavone, F. (2020) "Study of Slow Waves (SWs) propagation through wide-field calcium imaging of the right cortical hemisphere of GCaMP6f mice" EBRAINS. doi: 10.25493/3E6Y-E8G; Resta, F., Allegra Mascaro, A. L., & Pavone, F. (2021) "Study of Slow Waves (SWs) propagation through wide-field calcium imaging of the right cortical hemisphere of GCaMP6f mice (v2)" EBRAINS. doi: 10.25493/QFZK-FXS; Resta, F., [5] Allegra Mascaro, A. L., & Pavone, F. (2020) "Wide-field calcium imaging of the right cortical hemisphere of GCaMP6f mice at different anesthesia levels" EBRAINS. doi: 10.25493/XJR8-QCA[6] Brochier, T. et al. (2018) “Massively Parallel Recordings in Macaque Motor Cortex during an Instructed Delayed Reach-to-Grasp Task.” Scientific Data 5 (1): 180055. doi: 10.1038/sdata.2018.55.[7] Garcia, S. et al. (2014) “Neo: an object model for handling electrophysiology data in multiple formats.” Frontiers in Neuroinformatics 8:10. doi: 10.3389/fninf.2014.00010[8] De Bonis, G. et al. (2019) "Analysis pipeline for extracting features of cortical slow oscillations". Frontiers in Systems Neuroscience 13:70. doi: 10.3389/fnsys.2019.00070[9] Celotto, M. et al. (2020) “Analysis and Model of Cortical Slow Waves Acquired with Optical Techniques”. Methods and Protocols 3.1:14. doi: 10.3390/mps3010014[10] Dasilva, M., et al. (2020). Modulation of cortical slow oscillations and complexity across anesthesia levels. NeuroImage, 224, 117415. doi: 10.1016/j.neuroimage.2020.117415[11] Liang, Y. (2021). “Cortex-Wide Dynamics of Intrinsic Electrical Activities: Propagating Waves and Their Interactions.” Journal of Neuroscience 41 (16): 3665–78. doi: 10.1523/JNEUROSCI.0623-20.2021

Published
2022

15. New generation of light sources for applications in spectroscopy

Author

Inguscio, M., Cataliotti, F. S., Fort, C., Pavone, F. S., Prevedelli, M., Araki, H., editor, Beig, R., editor, Ehlers, J., editor, Frisch, U., editor, Hepp, K., editor, Jaffe, R. L., editor, Kippenhahn, R., editor, Weidenmüller, H. A., editor, Wess, J., editor, Zittartz, J., editor, Beiglböck, W., editor, Lehr, Sabine, editor, Jungmann, Klaus Peter, editor, Kowalski, Joachim, editor, Reinhard, Irene, editor, and Träger, Frank, editor

Published
1997
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23. Functional Optoacoustic Imaging

Author

Pavone, Francesco S, Shoham, Shy, Pavone, F S ( Francesco S ), Shoham, S ( Shy ), Razansky, Daniel; https://orcid.org/0000-0001-8676-0964, Pavone, Francesco S, Shoham, Shy, Pavone, F S ( Francesco S ), Shoham, S ( Shy ), and Razansky, Daniel; https://orcid.org/0000-0001-8676-0964

Abstract

Promising new developments include the introduction of near-infrared-shifted fluorescent molecules that can be used for in vivo labeling of deep tissue functional and molecular processes. Due to versatility and wide availability of optical molecular agents, functional and molecular imaging studies can be done using extrinsic contrast from, e.g. reporter genes or targeted biomarkers that can be genetically expressed or accumulated in a cell- or tissue-specific manner. Despite its great promise, similarly to ultrasonography, optoacoustic imaging possesses several limitations related to imaging through acoustically mismatched areas, such as lungs, skull, and bones. The initial goal of optoacoustic imaging and tomography is retrieval of the absorbed optical energy density inside the object. The highly heterogeneous nature of biological tissues may further lead to the appearance of significant image artifacts and compromise imaging performance and quantification. The true multi-scale imaging capabilities of optoacoustics can be better appreciated when comparing its dynamic imaging performance with other neuroimaging modalities.

Published
2020

31. Letter to the Editor

Author

Crocini, C., primary, Ferrantini, C., additional, Coppini, R., additional, Pavone, F. S., additional, Poggesi, C., additional, Cerbai, E., additional, and Sacconi, L., additional

Published
2019
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34. Optical spectral signatures of liquids by means of fiber optic technology for product and quality parameter identification

Author

Mignani A. G., Ciaccheri L., Mencaglia A. A., Díaz-Herrera N., García-Allende P. B., Ottevaere H., Thienpont H., Attilio C., Cimato A., Francalanci S., Paccagnini A., and Pavone F. S.

Subjects
uv-vis-nir spectroscopy, multivariate data processing, olive oil, lubricant oil, Applied optics. Photonics, TA1501-1820, Optics. Light, QC350-467
Abstract

Absorption spectroscopy in the wide 200–1700 nm spectral range is carried out by means of optical fiber instrumentation to achieve a digital mapping of liquids for the prediction of important quality parameters. Extra virgin olive oils from Italy and lubricant oils from turbines with different degrees of degradation were considered as ’case studies’. The spectral data were processed by means of multivariate analysis so as to obtain a correlation to quality parameters. In practice, the wide range absorption spectra were considered as an optical signature of the liquids from which to extract product quality information. The optical signatures of extra virgin olive oils were used to predict the content of the most important fatty acids. The optical signatures of lubricant oils were used to predict the concentration of the most important parameters for indicating the oil’s degree of degradation, such as TAN, JOAP anti-wear index, and water content.

Published
2009
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36. Far-infrared self-broadening in methylcyanide - Absorber-perturber resonance

Author

Buffa, G, Tarrini, O, De Natale, P, Inguscio, M, Pavone, F. S, Prevedelli, M, Evenson, K. M, Zink, L. R, and Schwaab, G. W

Subjects
Atomic And Molecular Physics
Abstract

Using tunable far-infrared spectrometers with high-frequency stability and accuracy, the self-pressure broadening and shift of CH3CN are measured. Evidence of absorber-perturber resonance effects on the collisional line shape are obtained. This tests the theoretical model and its possible improvements and also allows predictions of broadening and shift for a large class of molecules. Moreover, the resonance effect produces a theoretical temperature dependence of self-broadening that is different from what is commonly assumed.

Published
1992
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37. Real‐time optical manipulation of cardiac conduction in intact hearts

Author

Scardigli, M., primary, Müllenbroich, C., additional, Margoni, E., additional, Cannazzaro, S., additional, Crocini, C., additional, Ferrantini, C., additional, Coppini, R., additional, Yan, P., additional, Loew, L. M., additional, Campione, M., additional, Bocchi, L., additional, Giulietti, D., additional, Cerbai, E., additional, Poggesi, C., additional, Bub, G., additional, Pavone, F. S., additional, and Sacconi, L., additional

Published
2018
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40. Microscopy Applied to Biophotonics

Author

French, P. M. W., So, P. T. C., Pavone, F. S., French, P. M. W., So, P. T. C., and Pavone, F. S.

Subjects
Microscopy--Congresses, Photonics--Congresses, Fluorescence microscopy--Congresses
Abstract

Biophotonics and microscopy are highly inter-related fields in terms of both technological development and biomedical applications. Recent advances in microscopy have been paralleled by new opportunities for biophotonics, including the investigation and manipulation of biological phenomena using light and its application to biomedicine. This book contains papers from the Enrico Fermi International School of Physics on Microscopy Applied to Biophotonics, held in Varenna, Italy, in July 2011. The lectures spanned the basic science of imaging, through advanced microscopy techniques, to the state-of-the-art in biomedical imaging, and were complemented by seminars from world leaders in biophotonics. Subjects covered include: an overview of biophotonics; fundamentals of microscopy and an introduction to nonlinear microscopy; fluorescence; lasers for biophotonics; and an introduction to ultra-microscopy.

Published
2014

48. Lamb dip and infrared–radio frequency double resonance spectroscopy of 188OsO4.

Author

Ricci, L., Pavone, F. S., Prevedelli, M., Zink, L. R., Inguscio, M., Scappini, F., and Sassi, M. P.

Subjects
*FLUORESCENCE, *SPECTRUM analysis, *OSMIUM compounds
Abstract

The frequency of seven rovibrational transitions in the ν3 band, Q branch of 188OsO4 have been measured with high accuracy. The spectrometer used consists of two CO2 lasers [∼3 W on the 10R(0)], the first of which is stabilized on the 4.3 μm fluorescence Lamb dip of the CO2 and the second on the saturated absorption dip of the rovibrational transitions of 188OsO4. The OsO4 transition frequencies are obtained combining the known frequency of the first laser with the measured frequency of the beat note between the two laser beams. For the assignment of the transitions the recent Fourier transform analysis by Bobin et al. [J. Mol. Spectrosc. 122, 229 (1987)] was used. The access to the 10R(0) laser line has made it possible to investigate, for the first time, the Q branch of the ν3 band of OsO4 in a sub-Doppler regime. Furthermore, the tetrahedral fine structure in the ground and in the ν3 state has been analyzed using the infrared–radio frequency double resonance technique. The tetrahedral splitting constants, Dt for the ground state and Z3t for the ν3 state, have been calculated with higher accuracy than in previous works. [ABSTRACT FROM AUTHOR]

Published
1991
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49. Correcting Spherical Aberrations in Confocal Light Sheet Microscopy: A Theoretical Study

Author

Silvestri, L., Sacconi, L., and Pavone, F. S.

Subjects
optical clearing, brain imaging, fluorescence microscopy
Abstract

In the last years, fluorescence light sheet microscopy has attracted an increasing interest among the microscopy community. One of the most promising applications of this technique is the reconstruction of macroscopic biological specimens with microscopic resolution, without physical sectioning. To this aim, light sheet microscopy is combined with clearing protocols based on refractive index matching, which render the tissue transparent. However, these protocols lead to a huge drop in the fluorescence signal, limiting their practical applicability. The reduction of signal to background ratio is commonly ascribed to chemical degradation of the fluorophores by the organic solvents used for clearing. This view however completely neglects another important factor of contrast loss, i.e., optical aberrations. In fact, commercially available objectives suitable for light sheet microscopy are not designed for the refractive index of the clearing solutions, and this mismatch introduces severe spherical aberration. Here we simulated the aberrated point spread function (PSF) of a light sheet microscope with confocal slit detection. We investigated the variation of the PSF as a function of objective numerical aperture (NA) and of imaging depth inside the clearing solution. We also explored the possibility of correcting such spherical aberration by introducing extra optical devices in the detection path. By correcting up to the second order spherical aberration, a quasi-diffraction-limited regime can be recovered, and image quality is restored. (C) 2014 Wiley Periodicals, Inc.

Published
2014
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50. Poster session 1Cell growth, differentiation and stem cells - Heart72Understanding the metabolism of cardiac progenitor cells: a first step towards controlling their proliferation and differentiation?73Expression of pw1/peg3 identifies a new cardiac adult stem cell population involved in post-myocardial infarction remodeling74Long-term stimulation of iPS-derived cardiomyocytes using optogenetic techniques to promote phenotypic changes in E-C coupling75Benefits of electrical stimulation on differentiation and maturation of cardiomyocytes from human induced pluripotent stem cells76Constitutive beta-adrenoceptor-mediated cAMP production controls spontaneous automaticity of human induced pluripotent stem cell-derived cardiomyocytes77Formation and stability of T-tubules in cardiomyocytes78Identification of miRNAs promoting human cardiomyocyte proliferation by regulating Hippo pathway79A direct comparison of foetal to adult epicardial cell activation reveals distinct differences relevant for the post-injury response80Role of neuropilins in zebrafish heart regeneration81Highly efficient immunomagnetic purification of cardiomyocytes derived from human pluripotent stem cells82Cardiac progenitor cells posses a molecular circadian clock and display large 24-hour oscillations in proliferation and stress tolerance83Influence of sirolimus and everolimus on bone marrow-derived mesenchymal stem cell biology84Endoglin is important for epicardial behaviour following cardiac injuryCell death and apoptosis - Heart87Ultrastructural alterations reflecting Ca2+ handling and cell-to-cell coupling disorders precede occurrence of severe arrhythmias in intact animal heart88Urocortin-1 promotes cardioprotection through ERK1/2 and EPAC pathways: role in apoptosis and necrosis89Expression p38 MAPK and Cas-3 in myocardium LV of rats with experimental heart failure at melatonin and enalapril introductionTranscriptional control and RNA species - Heart92Accumulation of beta-amyloid 1-40 in HF patients: the role of lncRNA BACE1-AS93Role of miR-182 in zebrafish and mouse models of Holt-Oram syndrome94Mir-27 distinctly regulates muscle-enriched transcription factors and growth factors in cardiac and skeletal muscle cells95AF risk factors impair PITX2 expression leading to Wnt-microRNA-ion channel remodelingCytokines and cellular inflammation - Heart98Post-infarct survival depends on the interplay of monocytes, neutrophils and interferon gamma in a mouse model of myocardial Infarction99Inflammatory cd11b/c cells play a protective role in compensated cardiac hypertrophy by promoting an orai3-related pro-survival signal100Anti-inflammatory effects of endothelin receptor blockade in the atrial tissue of spontaneously hypertensive rats101Mesenchymal stromal cells reduce NLRP3 inflammasome activity in Coxsackievirus B3-induced myocarditis102Mesenchymal stromal cells modulate monocytes trafficking in Coxsackievirus B3-induced myocarditis103The impact of regulatory T lymphocytes on long-term mortality in patients with chronic heart failure104Temporal dynamics of dendritic cells after ST-elevation myocardial infarction relate with improvement of myocardial functionGrowth factors and neurohormones - Heart107Preconditioning of hypertrophied heart: miR-1 and IGF-1 crosstalk108Modulation of catecholamine secretion from human adrenal chromaffin cells by manipulation of G protein-coupled receptor kinase-2 activity109Evaluation of cyclic adenosin-3,5- monophosphate and neurohormones in patients with chronic heart failureNitric oxide and reactive oxygen species - Heart112Hydrogen sulfide donor inhibits oxidative and nitrosative stress, cardiohemodynamics disturbances and restores cNOS coupling in old rats113Role and mechanisms of action of aldehydes produced by monoamine oxidase A in cardiomyocyte death and heart failure114Exercise training has contrasting effects in myocardial infarction and pressure-overload due to different endothelial nitric oxide synthase regulation115S-Nitroso Human Serum Albumin dose-dependently leads to vasodilation and alters reactive hyperaemia in coronary arteries of an isolated mouse heart model116Modulating endothelial nitric oxide synthase with folic acid attenuates doxorubicin-induced cardiomyopathy119Effects of long-term very high intensity exercise on aortic structure and function in an animal model120Electron paramagnetic resonance spectroscopy quantification of nitrosylated hemoglobin (HbNO) as an index of vascular nitric oxide bioavailability in vivo121Deletion of repressor activator protein 1 impairs acetylcholine-induced relaxation due to production of reactive oxygen speciesExtracellular matrix and fibrosis - Heart124MicroRNA-19b is associated with myocardial collagen cross-linking in patients with severe aortic stenosis. Potential usefulness as a circulating biomarker125A new ex vivo model to study cardiac fibrosis126Heterogeneity of fibrosis and fibroblast differentiation in the left ventricle after myocardial infarction127Effect of carbohydrate metabolism degree compensation to the level of galectin-3 changes in hypertensive patients with chronic heart failure and type 2 diabetes mellitus128Statin paradox in association with calcification of bicuspid aortic valve interstitial cells129Cardiac function remains impaired despite reversible cardiac fibrosis after healed experimental viral myocarditisIon channels, ion exchangers and cellular electrophysiology - Heart132Identifying a novel role for PMCA1 (Atp2b1) in heart rhythm instability133Mutations of the caveolin-3 gene as a predisposing factor for cardiac arrhythmias134The human sinoatrial node action potential: time for a computational model135iPSC-derived cardiomyocytes as a model to dissect ion current alterations of genetic atrial fibrillation136Postextrasystolic potentiation in healthy and diseased hearts: effects of the site of origin and coupling interval of the preceding extrasystole137Absence of Nav1.8-based (late) sodium current in rabbit cardiomyocytes and human iPSC-CMs138hiPSC-derived cardiomyocytes from Brugada Syndrome patients without identified mutations do not exhibit cellular electrophysiological abnormalitiesMicrocirculation141Atherogenic indices, collagen type IV turnover and the development of microvascular complications- study in diabetics with arterial hypertension142Changes in the microvasculature and blood viscosity in women with rheumatoid arthritis, hypercholesterolemia and hypertensionAtherosclerosis145Shear stress regulates endothelial autophagy: consequences on endothelial senescence and atherogenesis146Obstructive sleep apnea causes aortic remodeling in a chronic murine model147Aortic perivascular adipose tissue displays an aged phenotype in early and late atherosclerosis in ApoE-/- mice148A systematic evaluation of the cellular innate immune response during the process of human atherosclerosis149Inhibition of Coagulation factor Xa increases plaque stability and attenuates the onset and progression of atherosclerotic plaque in apolipoprotein e-deficient mice150Regulatory CD4+ T cells from patients with atherosclerosis display pro-inflammatory skewing and enhanced suppression function151Hypoxia-inducible factor (HIF)-1alpha regulates macrophage energy metabolism by mediating miRNAs152Extracellular S100A4 is a key player of smooth muscle cell phenotypic transition: implications in atherosclerosis153Microparticles of healthy origins improve atherosclerosis-associated endothelial progenitor cell dysfunction via microRNA transfer154Arterial remodeling and metabolism impairment in early atherosclerosis155Role of pannexin1 in atherosclerotic plaque formationCalcium fluxes and excitation-contraction coupling158Amphiphysin II induces tubule formation in cardiac cells159Interleukin 1 beta regulation of connexin 43 in cardiac fibroblasts and the effects of adult cardiac myocyte:fibroblast co-culture on myocyte contraction160T-tubular electrical defects contribute to blunted beta-adrenergic response in heart failure161Beat-to-beat variability of intracellular Ca2+ dynamics of Purkinje cells in the infarct border zone of the mouse heart revealed by rapid-scanning confocal microscopy162The efficacy of late sodium current blockers in hypertrophic cardiomyopathy is dependent on genotype: a study on transgenic mouse models with different mutations163Synthesis of cADPR and NAADP by intracellular CD38 in heart: role in inotropic and arrhythmogenic effects of beta-adrenoceptor signalingContractile apparatus166Towards an engineered heart tissue model of HCM using hiPSC expressing the ACTC E99K mutation167Diastolic mechanical load delays structural and functional deterioration of ultrathin adult heart slices in culture168Structural investigation of the cardiac troponin complex by molecular dynamics169Exercise training restores myocardial and oxidative skeletal muscle function from myocardial infarction heart failure ratsOxygen sensing, ischaemia and reperfusion172A novel antibody specific to full-length stromal derived factor-1 alpha reveals that remote conditioning induces its cleavage by endothelial dipeptidyl peptidase 4173Attenuation of myocardial and vascular arginase activity by vagal nerve stimulation via a mechanism involving alpha-7 nicotinic receptor during cardiac ischemia and reperfusion174Novel nanoparticle-mediated medicine for myocardial ischemia-reperfusion injury simultaneously targeting mitochondrial injury and myocardial inflammation175Acetylcholine plays a key role in myocardial ischaemic preconditioning via recruitment of intrinsic cardiac ganglia176The role of nitric oxide and VEGFR-2 signaling in post ischemic revascularization and muscle recovery in aged hypercholesterolemic mice177Efficacy of ischemic preconditioning to protect the human myocardium: the role of clinical conditions and treatmentsCardiomyopathies and fibrosis180Plakophilin-2 haploinsufficiency leads to impaired canonical Wnt signaling in ARVC patient181Improved technique for customized, easier, safer and more reliable transverse aortic arch banding and debanding in mice as a model of pressure overload hypertrophy182Late sodium current inhibitors for the treatment of inducible obstruction and diastolic dysfunction in hypertrophic cardiomyopathy: a study on human myocardium183Angiotensin II receptor antagonist fimasartan has protective role of left ventricular fibrosis and remodeling in the rat ischemic heart184Role of High-Mobility Group Box 1 (HMGB1) redox state on cardiac fibroblasts activities and heart function after myocardial infarction185Atrial remodeling in hypertrophic cardiomyopathy: insights from mouse models carrying different mutations in cTnT186Electrophysiological abnormalities in ventricular cardiomyocytes from a Maine Coon cat with hypertrophic cardiomyopathy: effects of ranolazine187ZBTB17 is a novel cardiomyopathy candidate gene and regulates autophagy in the heart188Inhibition of SRSF4 in cardiomyocytes induces left ventricular hypertrophy189Molecular characterization of a novel cardiomyopathy related desmin frame shift mutation190Autonomic characterisation of electro-mechanical remodeling in an in-vitro leporine model of heart failure191Modulation of Ca2+-regulatory function by three novel mutations in TNNI3 associated with severe infant restrictive cardiomyopathyAging194The aging impact on cardiac mesenchymal like stromal cells (S+P+)195Reversal of premature aging markers after bariatric surgery196Sex-associated differences in vascular remodeling during aging: role of renin-angiotensin system197Role of the receptor for advanced glycation end-products (RAGE) in age dependent left ventricle dysfunctionsGenetics and epigenetics200hsa-miR-21-5p as a key factor in aortic remodeling during aneurysm formation201Co-inheritance of mutations associated with arrhythmogenic and hypertrophic cardiomyopathy in two Italian families202Lamin a/c hot spot codon 190: form various amino acid substitutions to clinical effects203Treatment with aspirin and atorvastatin attenuate cardiac injury induced by rat chest irradiation: Implication of myocardial miR-1, miR-21, connexin-43 and PKCGenomics, proteomics, metabolomics, lipidomics and glycomics206Differential phosphorylation of desmin at serines 27 and 31 drives the accumulation of preamyloid oligomers in heart failure207Potential role of kinase Akt2 in the reduced recovery of type 2 diabetic hearts subjected to ischemia / reperfusion injury208A proteomics comparison of extracellular matrix remodelling in porcine coronary arteries upon stent implantationMetabolism, diabetes mellitus and obesity211Targeting grk2 as therapeutic strategy for cancer associated to diabetes212Effects of salbutamol on large arterial stiffness in patients with metabolic syndrome213Circulating microRNA-1 and microRNA-133a: potential biomarkers of myocardial steatosis in type 2 diabetes mellitus214Anti-inflammatory nutrigenomic effects of hydroxytyrosol in human adipocytes - protective mechanisms of mediterranean diets in obesity-related inflammation215Alterations in the metal content of different cardiac regions within a rat model of diabetic cardiomyopathyTissue engineering218A novel conductive patch for application in cardiac tissue engineering219Establishment of a simplified and improved workflow from neonatal heart dissociation to cardiomyocyte purification and characterization220Effects of flexible substrate on cardiomyocytes cell culture221Mechanical stretching on cardiac adipose progenitors upregulates sarcomere-related genes

Author

Andre, E, primary, Yaniz-Galende, E, primary, Hamilton, C, primary, Dusting, G J, primary, Hellen, N, primary, Poulet, CE, primary, Diez Cunado, M, primary, Smits, AM, primary, Lowe, V, primary, Eckardt, D, primary, Du Pre, B, primary, Sanz Ruiz, R, primary, Moerkamp, A T, primary, Tribulova, N, primary, Smani, T, primary, Liskova, Y V, primary, Greco, S, primary, Guzzolino, E, primary, Franco, D, primary, Lozano-Velasco, E, primary, Knorr, M, primary, Pavoine, C, primary, Bukowska, A, primary, Van Linthout, S, primary, Miteva, K, primary, Sulzgruber, P, primary, Latet, S C, primary, Portnychenko, A, primary, Cannavo, A, primary, Kamilova, U, primary, Sagach, VF, primary, Santin, Y, primary, Octavia, Y, primary, Haller, PM, primary, Rubies, C, primary, Dei Zotti, F, primary, Wong, KHK, primary, Gonzalez Miqueo, A, primary, Kruithof, BPT, primary, Kadur Nagaraju, C, primary, Shaposhnikova, Y, primary, Songia, P, primary, Lindner, D, primary, Wilson, C, primary, Benzoni, P, primary, Fabbri, A, primary, Campostrini, G, primary, Jorge, E, primary, Casini, S, primary, Mengarelli, I, primary, Nikolov, A, primary, Bublikov, DS, primary, Kheloufi, M, primary, Walker, R E, primary, Van Dijk, RA, primary, Posthuma, JJ, primary, Dumitriu, I E, primary, Karshovska, E, primary, Sakic, A, primary, Alexandru, N, primary, Martin-Lorenzo, M, primary, Molica, F, primary, Taylor, RF, primary, Mcarthur, L, primary, Crocini, C, primary, Matsuyama, T-A, primary, Mazzoni, L, primary, Lin, W K, primary, Owen, TJ, primary, Scigliano, M, primary, Sheehan, A, primary, Bezerra Gurgel, A R, primary, Bromage, DI, primary, Kiss, A, primary, Ikeda, G, primary, Pickard, J M J, primary, Wirth, G, primary, Casos, K, primary, Khudiakov, A, primary, Nistal, JF, primary, Ferrantini, C, primary, Park, S-J, primary, Di Maggio, S, primary, Gentile, F, primary, Dini, L, primary, Buyandelger, B, primary, Larrasa-Alonso, J, primary, Schirmer, I, primary, Chin, SH, primary, Cimiotti, D, primary, Martini, 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2016
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