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The issue of domestic violence is neglected in current medical practice and the diagnosis associated with it thus escapes the attention of medical professionals. In this case report, we demonstrate rare and typical diseases of abused women, which should become warning signs for physicians (red flags) and lead them to screen domestic violence and intervene early. Failure to recognize domestic abuse as the cause of chronic health problems leads to lasting consequences and economically and personally burdens the health care system. Healthcare professionals of all specialties encounter abused women during their clinical practice and can thus actively participate in the prevention of domestic violence. However, it is women of reproductive age who are most at risk, so educating gynecologists and obstetricians on this issue is crucial. The aim of this article with a case study is to demonstrate the syndrome of a battered woman, its recognition and the possibility of immediate and brief intervention. Key words: chronic subdural hematoma – domestic violence – postdural puncture headache

Kyselina alfa-lipoova je přirodnim antioxidantem a kofaktorem mitochondrialnich enzymů oxidativniho metabolismu. Na podkladě klinických studii je považovana za podpůrnou lecbu bolesti u diabeticke neuropatie, v ostatnich indikacich je třeba dalsiho zkoumani.

Aims: The purpose of this international survey was to describe the impact of current practices and techniques of caesarean section on the neonatal Apgar score in the Czech Republic (CZE) and Slovakia (SVK). Methods: All Czech and Slovak departments that provide obstetric anaesthesia were invited to participate in a one-month (November 2015) prospective study that monitored in details all peripartum anaesthetic practices, delivered by anaesthesiologists. Participating centers recorded all data on-line in the CLADE-IS database (Masaryk University, CZE). Results and Discussions. We collected data of 10119 women who delivered 10226 newborns. A caesarean section was recorded in 25.1% of deliveries (CZE 23.2%; SVK 30%). General anaesthesia was used for caesarean section in 37.5% of the cases (CZE 40%, SVK 33%). There was no statistically significant difference in the Apgar score lower than 7 in the 1, 5 or 10 min in groups of general and regional anaesthesia for caesarean section, when only elective sections of in-term babies with birth weight over 2500 g were analyzed. We found no statistically significant differences in the Apgar score in newborns of women intubated for caesarean section in rocuronium (n=21; 2.2%) and suxamethonium (n=889; 93%). Conclusion: We found no difference in neonatal outcomes in groups of general and regional anaesthesia for caesarean section when only out-of-risk newborns were analyzed. The risk factors were identified as follows: an acute caesarean section, preterm babies, birth weight less than 2 500 g, born in perinatological center and multiple pregnancy - second baby. Trial Registration: ClinicalTrials.gov (ID: NCT02380586) https://clinicaltrials.gov/ct2/show/NCT02380586

Epiduralni porodni analgezie představuje nejucinnějsi metodu porodni analgezie, avsak v Ceske republice ne přilis rozsiřenou. Cilem clanku je přibližit teorii metody a popsat jeji prakticke provedeni i možne komplikace.

Postherpeticka neuralgie reprezentuje neuropatickou bolest v souvislosti s výskytem infekce herpes-zoster. Jeji lecba je systemovaa lokalni a opira se o doporuceni neurologických spolecnosti na urovni narodni i mezinarodni. Jako leky prvni volby jsouzdůrazňovana antiepileptika, antidepresiva a lokalni lidokain.

The aim of OBAAMA-INT survey (Obstetric Anaesthesia and Analgesia Month Attributes – International) was to audit the current practices in obstetric anaesthesia in the Czech Republic (CZE) and Slovakia (SVK). We also wanted to assess the potential benefit of education of healthcare providers in obstetric anaesthesia during the last 4 years. We already published data about analgesia for labour gathered from OBAAMA-INT survey in International Journal of Obstetric Anesthesia.

Onset times and conditions for intubation after rocuronium versus suxamethonium at cesarean section have been evaluated, but no study thus far has examined the influence of these neuromuscular blocking drugs on the surgical conditions or their effect on the duration of surgery and the ease of fetal delivery. We aimed to compare the surgical conditions for delivery in parturients who received deep neuromuscular block with rocuronium with those who had induction with suxamethonium.Ninety patients undergoing cesarean section under general anesthesia were randomized to receive either rocuronium 0.6 mg/kg or suxamethonium 1 mg/kg for tracheal intubation and delivery. Times to delivery and the quality of surgical conditions, using a five-point Surgical Rating Scale for Delivery (SRSD) ranging from 1 (poor) to 5 (excellent), were evaluated.The median SRSD (range) was found to be significantly better in the rocuronium group [4 (3-5) points vs 3 (2-4) points with suxamethonium (P 0.001)]. Whereas the mean (SD) induction-to-intubation interval was longer with rocuronium [106 (34) s vs 68 (32) s with suxamethonium (95% CI of the difference 24 to 52 s, P 0.001)], the incision-to-delivery interval was shorter in the rocuronium group [147 (68) s vs 196 (51) s with suxamethonium (95% CI of the difference -75 to -24 s, P 0.001)]. The mean induction-to-delivery intervals were similar [268 (73) s vs 276 (63) s, respectively].Whereas the induction-to-delivery intervals were comparable, we found rocuronium superior to suxamethonium in allowing better surgical conditions for fetal delivery, which enabled an easier delivery and a shorter incision-to-delivery interval.

Background Remifentanil has been suggested for its short duration of action to replace standard opioids for induction of general anaesthesia in caesarean section. While the stabilizing effect of remifentanil on maternal circulation has been confirmed, its effect on postnatal adaptation remains unclear, as currently published studies are not powered sufficiently to detect any clinical effect of remifentanil on the newborn. Methods Using a double-blinded randomized design, a total of 151 parturients undergoing caesarean delivery under general anaesthesia were randomized into two groups – 76 patients received a bolus of remifentanil prior to induction, while 75 patients were assigned to the control group. Remifentanil 1 μg/kg was administered 30 seconds before the standard induction of general anaesthesia. The primary outcome measure was an assessment of neonatal adaptation using the Apgar score, while secondary outcomes included the need for respiratory support after delivery and differences in umbilical blood gas analysis (Astrup). Results The incidence of lower Apgar scores between 0 and 7 was significantly higher in the remifentanil group at one minute (25% vs. 9.3% of newborns, p = 0.017); whilst at five minutes and later no Apgar score differences were observed. There was no difference in the need for moderate (nasal CPAP) or intensive (intubation) respiratory support, but significantly more neonates in the remifentanil group required tactile stimulation for breathing support (21% vs. 7% of newborns, p = 0.017). There was no difference in the parameters from umbilical cord blood gas analysis between the groups. Conclusion At a dose of 1 μg/kg, remifentanil prior to induction of general anaesthesia increases the risk of neonatal respiratory depression during first minutes after caesarean delivery but duration of clinical symptoms is short. Trial registration ClinicalTrials.gov: NCT01550640.

Die Anwendung von Opioiden vor Abnabelung des Neugeboren wird zur Vermeidung respiratorischer Komplikationen bei der ITN-Sectio nicht empfohlen. Die Folgen sind eine unzureichende Analgesie und Anasthesietiefe sowie kardiozirkulatorische Schwankungen, die beim Anasthesisten Unsicherheit und Unzufriedenheit hervorrufen. Remifentanil als ultrakurzwirksamer μ 1 -Rezeptoragonist passiert zwar die Plazentaschranke, scheint aber aufgrund der kurzen Halbwertszeit von 3–10 min und dem enzymatischen Umbau durch unspezifische Plasmaesterasen zur perioperativen Analgesie geeignet. Der Einsatz bei ITN-Sectio erfolgt jedoch aufgrund der moglichen Atemdepression des Neugeborenen zurzeit nur in wenigen Kliniken, wahrend Remifentanil durchaus als Alternative bei Spontanpartus gilt, wenn Kontraindikationen fur die Periduralanasthesie vorliegen.

At present, the anaesthesia team became an integral part of the multispecialized team caring for woman in the peripartum period. The aim of this study is to describe anaesthesia practice in the peripartum period in the Czech Republic (CZ).

The aim of our study was to evaluate possible effect of ABCB1, and OPRM1 polymorphisms on the efficacy and safety of remifentanil in women undergoing elective cesarean section under general anesthesia. Women received remifentanil (1 µg/kg i.v.) 30 s prior to the induction to standardized general anesthesia. The ABCB1 (rs2032582, rs1045642) and OPRM1 (rs1799971) polymorphisms were analyzed from maternal peripheral blood. The basal hemodynamic and demographic parameters in the study population (n=54) were similar in all the subgroups. The median ± SD increase of systolic blood pressure at 5 min from the baseline was practically completely abolished in homozygous carriers of ABCB1 variants in comparison with wild-type subjects -2.67±25.0 vs. 16.57±15.7 mm Hg, p