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26 results on '"Paveliev, Mikhail"'

3. Investigation of NO Role in Neural Tissue in Brain and Spinal Cord Injury

Author

Andrianov, Viacheslav V., primary, Kulchitsky, Vladimir A., additional, Yafarova, Guzel G., additional, Bazan, Leah V., additional, Bogodvid, Tatiana K., additional, Deryabina, Irina B., additional, Muranova, Lyudmila N., additional, Silantyeva, Dinara I., additional, Arslanov, Almaz I., additional, Paveliev, Mikhail N., additional, Fedorova, Ekaterina V., additional, Filipovich, Tatiana A., additional, Nagibov, Aleksei V., additional, and Gainutdinov, Khalil L., additional

Published
2023
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4. An EPR Spectroscopy Study of NO and Copper Content in Injured and Uninjured Areas of the Brain After a Combined Injury of the Brain and Spinal Cord in Rats

Author

Andrianov, Viacheslav V, primary, Kulchitsky, Vladimir A, additional, Yafarova, Guzel G, additional, Bazan, Lyeo V, additional, Bogodvid, Tatiana K, additional, Deryabina, Irina B, additional, Muranova, Lyudmila N, additional, Silantyeva, Dinara V, additional, Arslanov, Almaz I, additional, Paveliev, Mikhail N, additional, Fedorova, Ekaterina, additional, Filipovich, Tatiana A, additional, Nagibov, Aleksei V, additional, and Gainutdinov, Khalil Latypovich, additional

Published
2023
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6. Postnatal development of the microstructure of cortical GABAergic synapses and perineuronal nets requires sensory input

Author

Lipachev, Nikita, primary, Melnikova, Anastasia, additional, Fedosimova, Svetlana, additional, Arnst, Nikita, additional, Kochneva, Anastasia, additional, Shaikhutdinov, Nurislam, additional, Dvoeglazova, Anastasia, additional, Titova, Angelina, additional, Mavlikeev, Mikhail, additional, Aganov, Albert, additional, Osin, Yuri, additional, Kiyasov, Andrei, additional, and Paveliev, Mikhail, additional

Published
2022
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8. Heparin-Binding Growth-Associated Molecule (Pleiotrophin) Affects Sensory Signaling and Selected Motor Functions in Mouse Model of Anatomically Incomplete Cervical Spinal Cord Injury

Author

Kulesskaya, Natalia, Molotkov, Dmitry, Sliepen, Sonny, Mugantseva, Ekaterina, Garcia Horsman, Arturo, Paveliev, Mikhail, Rauvala, Heikki, Neuroscience Center, Biosciences, Institute for Molecular Medicine Finland, Regenerative pharmacology group, and Faculty of Pharmacy

Subjects
EXPRESSION, HB-GAM, INTRINSIC SIGNAL, PERINEURONAL NETS, 3112 Neurosciences, PROTEIN, BOLD signal, RECOVERY, NEURITE OUTGROWTH, spinal cord injury, animal models, MICE, Neurology, GLIAL SCAR, REGENERATION, pleiotrophin, Neurology (clinical), Neurology. Diseases of the nervous system, RC346-429, Original Research, CHONDROITIN SULFATE PROTEOGLYCAN
Abstract

Heparin-binding growth-associated molecule (pleiotrophin) is a neurite outgrowth-promoting secretory protein that lines developing fiber tracts in juvenile CNS (central nervous system). Previously, we have shown that heparin-binding growth-associated molecule (HB-GAM) reverses the CSPG (chondroitin sulfate proteoglycan) inhibition on neurite outgrowth in the culture medium of primary CNS neurons and enhances axon growth through the injured spinal cord in mice demonstrated by two-photon imaging. In this study, we have started studies on the possible role of HB-GAM in enhancing functional recovery after incomplete spinal cord injury (SCI) using cervical lateral hemisection and hemicontusion mouse models. In vivo imaging of blood-oxygen-level-dependent (BOLD) signals associated with functional activity in the somatosensory cortex was used to assess the sensory functions during vibrotactile hind paw stimulation. The signal displays an exaggerated response in animals with lateral hemisection that recovers to the level seen in the sham-operated mice by injection of HB-GAM to the trauma site. The effect of HB-GAM treatment on sensory-motor functions was assessed by performance in demanding behavioral tests requiring integration of afferent and efferent signaling with central coordination. Administration of HB-GAM either by direct injection into the trauma site or by intrathecal injection improves the climbing abilities in animals with cervical hemisection and in addition enhances the grip strength in animals with lateral hemicontusion without affecting the spontaneous locomotor activity. Recovery of sensory signaling in the sensorimotor cortex by HB-GAM to the level of sham-operated mice may contribute to the improvement of skilled locomotion requiring integration of spatiotemporal signals in the somatosensory cortex.

Published
2021

9. SorCS2 Dynamically Interacts with TrkB and GluN2B to Control Neurotransmission and Huntington’s Disease Progression

Author

Salašová, Alena, primary, Degn, Niels Sanderhoff, additional, Paveliev, Mikhail, additional, Madsen, Niels Kjærgaard, additional, Benito, Saray López, additional, Casarotto, Plinio, additional, Ovesen, Peter Lund, additional, Vestergaard, Benedicte, additional, Udrea, Andreea Cornelia, additional, Kisiswa, Lilian, additional, Woloszczuková, Lucie, additional, Faress, Islam, additional, Nabavi, Sadegh, additional, Castrén, Eero, additional, Arévalo, Juan Carlos, additional, Holm, Mai Marie, additional, Kjølby, Mads Fuglsang, additional, Bølcho, Ulrik, additional, and Nykjaer, Anders, additional

Published
2022
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12. SorCS2 dynamically interacts with TrkB and GluN2B to control neurotransmission and Huntington’s disease progression

Author

Salasova, Alena, primary, Degn, Niels Sanderhoff, additional, Paveliev, Mikhail, additional, Madsen, Niels Kjærsgaard, additional, Benito, Saray Lopez, additional, Casarotto, Plinio, additional, Ovesen, Peter Lund, additional, Vestergaard, Benedicte, additional, Udrea, Andreea Cornelia, additional, Kisiswa, Lilian, additional, Woloszczukova, Lucie, additional, Faress, Islam, additional, Nabavi, Sadegh, additional, Castren, Eero, additional, Arevalo, Juan Carlos, additional, Holm, Mai Marie, additional, Kjølby, Mads Fuglsang, additional, Bølcho, Ulrik, additional, and Nykjaer, Anders, additional

Published
2021
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16. Fine structure analysis of perineuronal nets in the ketamine model of schizophrenia.

Author

Kaushik, Rahul, Lipachev, Nikita, Matuszko, Gabriela, Kochneva, Anastasia, Dvoeglazova, Anastasia, Becker, Axel, Paveliev, Mikhail, and Dityatev, Alexander

Subjects
PERINEURONAL nets, SPRAGUE Dawley rats, NEURAL transmission, SCHIZOPHRENIA, KETAMINE
Abstract

Perineuronal nets (PNNs) represent a highly condensed specialized form of brain extracellular matrix (ECM) enwrapping mostly parvalbumin‐positive interneurons in the brain in a mesh‐like fashion. PNNs not only regulate the onset and completion of the critical period during postnatal brain development, control cell excitability, and synaptic transmission but are also implicated in several brain disorders including schizophrenia. Holes in the perineuronal nets, harboring the synaptic contacts, along with hole‐surrounding ECM barrier can be viewed as PNN compartmentalization units that might determine the properties of synapses and heterosynaptic communication. In this study, we developed a novel open‐source script for Fiji (ImageJ) to semi‐automatically quantify structural alterations of PNNs such as the number of PNN units, area, mean intensity of PNN marker expression in 2D and 3D, shape parameters of PNN units in the ketamine‐treated Sprague–Dawley rat model of schizophrenia using high‐resolution confocal microscopic images. We discovered that the mean intensity of ECM within PNN units is inversely correlated with the area and the perimeter of the PNN holes. The intensity, size, and shape of PNN units proved to be three major principal factors to describe their variability. Ketamine‐treated rats had more numerous but smaller and less circular PNN units than control rats. These parameters allowed to correctly classify individual PNNs as derived from control or ketamine‐treated groups with ≈85% reliability. Thus, the proposed multidimensional analysis of PNN units provided a robust and comprehensive morphometric fingerprinting of fine ECM structure abnormalities in the experimental model of schizophrenia. [ABSTRACT FROM AUTHOR]

Published
2021
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17. Inhibition and enhancement of neural regeneration by chondroitin sulfate proteoglycans

Author

Rauvala, Heikki, Paveliev, Mikhail, Kuja-Panula, Juha, Kulesskaya, Natalia, Neuroscience Center, and Biosciences

Subjects
HEPARAN-SULFATE, PTEN, HB-GAM, dendrite regeneration, CENTRAL-NERVOUS-SYSTEM, PERINEURONAL NETS, axon regeneration, 3112 Neurosciences, GROWTH-ASSOCIATED MOLECULE, NEURITE OUTGROWTH, glypican, GLIAL SCAR, pleiotrophin, EXTRACELLULAR-MATRIX, SPINAL-CORD-INJURY, proteoglycans, CNS injury, aggrecan, IN-VIVO
Abstract

The current dogma in neural regeneration research implies that chondroitin sulfate proteoglycans (CSPGs) inhibit plasticity and regeneration in the adult central nervous system (CNS). We argue that the role of the CSPGs can be reversed from inhibition to activation by developmentally expressed CSPG-binding factors. Heparin-binding growth-associated molecule (HB-GAM; also designated as pleiotrophin) has been studied as a candidate molecule that might modulate the role of CSPG matrices in plasticity and regeneration. Studies in vitro show that in the presence of soluble HB-GAM chondroitin sulfate (CS) chains of CSPGs display an enhancing effect on neurite outgrowth. Based on the in vitro studies, we suggest a model according to which the HB-GAM/CS complex binds to the neuron surface receptor glypican-2, which induces neurite growth. Furthermore, HB-GAM masks the CS binding sites of the neurite outgrowth inhibiting receptor protein tyrosine phosphatase sigma (PTP sigma), which may contribute to the HB-GAM-induced regenerative effect. In vivo studies using two-photon imaging after local HB-GAM injection into prick-injury of the cerebral cortex reveal regeneration of dendrites that has not been previously demonstrated after injuries of the mammalian nervous system. In the spinal cord, two-photon imaging displays HB-GAM-induced axonal regeneration. Studies on the HB-GAM/CS mechanism in vitro and in vivo are expected to pave the way for drug development for injuries of brain and spinal cord.

Published
2017

19. Spatial patterns and cell surface clusters in perineuronal nets

Author

Arnst, Nikita, primary, Kuznetsova, Svetlana, additional, Lipachev, Nikita, additional, Shaikhutdinov, Nurislam, additional, Melnikova, Anastasiya, additional, Mavlikeev, Mikhail, additional, Uvarov, Pavel, additional, Baltina, Tatyana V., additional, Rauvala, Heikki, additional, Osin, Yuriy N., additional, Kiyasov, Andrey P., additional, and Paveliev, Mikhail, additional

Published
2016
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20. HB-GAM (pleiotrophin) reverses inhibition of neural regeneration by the CNS extracellular matrix

Author

Paveliev, Mikhail, primary, Fenrich, Keith K., additional, Kislin, Mikhail, additional, Kuja-Panula, Juha, additional, Kulesskiy, Evgeny, additional, Varjosalo, Markku, additional, Kajander, Tommi, additional, Mugantseva, Ekaterina, additional, Ahonen-Bishopp, Anni, additional, Khiroug, Leonard, additional, Kulesskaya, Natalia, additional, Rougon, Geneviève, additional, and Rauvala, Heikki, additional

Published
2016
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26. Structure of ribosomal protein L1 from Methanococcus thermolithotrophicus. Functionally important structural invariants on the L1 surface.

Author

Nevskaya, Natalia, Tishchenko, Svetlana, Paveliev, Mikhail, Smolinskaya, Yulia, Fedorov, Roman, Piendl, Wolfgang, Nakamura, Yoshikazu, Toyoda, Tomohiko, Garber, Maria, and Nikonov, Stanislav

Subjects
RIBOSOMES, PROTEINS, CRYSTALLOGRAPHY, NUCLEIC acids, RNA
Abstract

The crystal structure of ribosomal protein LI from the archaeon Methanococcus thermolithotrophicus has been determined at 2.7 Å resolution. The crystals belong to space group P212121, with unit-cell parameters a = 67.0, b = 70.1, c = 106.3 Å and two molecules per asymmetric unit. The structure was solved by the molecular-replacement method with AMoRe and refined with CNS to an R value of 18.9% and an Rfree of 25.4% in the resolution range 30-2.7 Å. Comparison of this structure with those obtained previously for two L1 proteins from other sources (the bacterium Thermus thermophilus and the arch aeon M. jannaschii) as well as detailed analysis of intermolecular contacts in the corresponding L1 crystals reveal structural invariants on the molecular surface which are probably important for binding the 23S ribosomal RNA and protein function within the ribosome. [ABSTRACT FROM AUTHOR]

Published
2002
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