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1. BraTS-PEDs: Results of the Multi-Consortium International Pediatric Brain Tumor Segmentation Challenge 2023

Author

Kazerooni, Anahita Fathi, Khalili, Nastaran, Liu, Xinyang, Haldar, Debanjan, Jiang, Zhifan, Zapaishchykova, Anna, Pavaine, Julija, Shah, Lubdha M., Jones, Blaise V., Sheth, Nakul, Prabhu, Sanjay P., McAllister, Aaron S., Tu, Wenxin, Nandolia, Khanak K., Rodriguez, Andres F., Shaikh, Ibraheem Salman, Montano, Mariana Sanchez, Lai, Hollie Anne, Adewole, Maruf, Albrecht, Jake, Anazodo, Udunna, Anderson, Hannah, Anwar, Syed Muhammed, Aristizabal, Alejandro, Bagheri, Sina, Baid, Ujjwal, Bergquist, Timothy, Borja, Austin J., Calabrese, Evan, Chung, Verena, Conte, Gian-Marco, Eddy, James, Ezhov, Ivan, Familiar, Ariana M., Farahani, Keyvan, Gandhi, Deep, Gottipati, Anurag, Haldar, Shuvanjan, Iglesias, Juan Eugenio, Janas, Anastasia, Elaine, Elaine, Karargyris, Alexandros, Kassem, Hasan, Khalili, Neda, Kofler, Florian, LaBella, Dominic, Van Leemput, Koen, Li, Hongwei B., Maleki, Nazanin, Meier, Zeke, Menze, Bjoern, Moawad, Ahmed W., Pati, Sarthak, Piraud, Marie, Poussaint, Tina, Reitman, Zachary J., Rudie, Jeffrey D., Saluja, Rachit, Sheller, MIcah, Shinohara, Russell Takeshi, Viswanathan, Karthik, Wang, Chunhao, Wiestler, Benedikt, Wiggins, Walter F., Davatzikos, Christos, Storm, Phillip B., Bornhorst, Miriam, Packer, Roger, Hummel, Trent, de Blank, Peter, Hoffman, Lindsey, Aboian, Mariam, Nabavizadeh, Ali, Ware, Jeffrey B., Kann, Benjamin H., Rood, Brian, Resnick, Adam, Bakas, Spyridon, Vossough, Arastoo, and Linguraru, Marius George

Subjects
Electrical Engineering and Systems Science - Image and Video Processing, Computer Science - Computer Vision and Pattern Recognition
Abstract

Pediatric central nervous system tumors are the leading cause of cancer-related deaths in children. The five-year survival rate for high-grade glioma in children is less than 20%. The development of new treatments is dependent upon multi-institutional collaborative clinical trials requiring reproducible and accurate centralized response assessment. We present the results of the BraTS-PEDs 2023 challenge, the first Brain Tumor Segmentation (BraTS) challenge focused on pediatric brain tumors. This challenge utilized data acquired from multiple international consortia dedicated to pediatric neuro-oncology and clinical trials. BraTS-PEDs 2023 aimed to evaluate volumetric segmentation algorithms for pediatric brain gliomas from magnetic resonance imaging using standardized quantitative performance evaluation metrics employed across the BraTS 2023 challenges. The top-performing AI approaches for pediatric tumor analysis included ensembles of nnU-Net and Swin UNETR, Auto3DSeg, or nnU-Net with a self-supervised framework. The BraTSPEDs 2023 challenge fostered collaboration between clinicians (neuro-oncologists, neuroradiologists) and AI/imaging scientists, promoting faster data sharing and the development of automated volumetric analysis techniques. These advancements could significantly benefit clinical trials and improve the care of children with brain tumors.

Published
2024

2. The Brain Tumor Segmentation in Pediatrics (BraTS-PEDs) Challenge: Focus on Pediatrics (CBTN-CONNECT-DIPGR-ASNR-MICCAI BraTS-PEDs)

Author

Kazerooni, Anahita Fathi, Khalili, Nastaran, Liu, Xinyang, Gandhi, Deep, Jiang, Zhifan, Anwar, Syed Muhammed, Albrecht, Jake, Adewole, Maruf, Anazodo, Udunna, Anderson, Hannah, Baid, Ujjwal, Bergquist, Timothy, Borja, Austin J., Calabrese, Evan, Chung, Verena, Conte, Gian-Marco, Dako, Farouk, Eddy, James, Ezhov, Ivan, Familiar, Ariana, Farahani, Keyvan, Franson, Andrea, Gottipati, Anurag, Haldar, Shuvanjan, Iglesias, Juan Eugenio, Janas, Anastasia, Johansen, Elaine, Jones, Blaise V, Khalili, Neda, Kofler, Florian, LaBella, Dominic, Lai, Hollie Anne, Van Leemput, Koen, Li, Hongwei Bran, Maleki, Nazanin, McAllister, Aaron S, Meier, Zeke, Menze, Bjoern, Moawad, Ahmed W, Nandolia, Khanak K, Pavaine, Julija, Piraud, Marie, Poussaint, Tina, Prabhu, Sanjay P, Reitman, Zachary, Rudie, Jeffrey D, Sanchez-Montano, Mariana, Shaikh, Ibraheem Salman, Sheth, Nakul, Tu, Wenxin, Wang, Chunhao, Ware, Jeffrey B, Wiestler, Benedikt, Zapaishchykova, Anna, Bornhorst, Miriam, Deutsch, Michelle, Fouladi, Maryam, Lazow, Margot, Mikael, Leonie, Hummel, Trent, Kann, Benjamin, de Blank, Peter, Hoffman, Lindsey, Aboian, Mariam, Nabavizadeh, Ali, Packer, Roger, Bakas, Spyridon, Resnick, Adam, Rood, Brian, Vossough, Arastoo, and Linguraru, Marius George

Subjects
Computer Science - Computer Vision and Pattern Recognition, Electrical Engineering and Systems Science - Image and Video Processing
Abstract

Pediatric tumors of the central nervous system are the most common cause of cancer-related death in children. The five-year survival rate for high-grade gliomas in children is less than 20%. Due to their rarity, the diagnosis of these entities is often delayed, their treatment is mainly based on historic treatment concepts, and clinical trials require multi-institutional collaborations. Here we present the CBTN-CONNECT-DIPGR-ASNR-MICCAI BraTS-PEDs challenge, focused on pediatric brain tumors with data acquired across multiple international consortia dedicated to pediatric neuro-oncology and clinical trials. The CBTN-CONNECT-DIPGR-ASNR-MICCAI BraTS-PEDs challenge brings together clinicians and AI/imaging scientists to lead to faster development of automated segmentation techniques that could benefit clinical trials, and ultimately the care of children with brain tumors., Comment: arXiv admin note: substantial text overlap with arXiv:2305.17033

Published
2024

3. The Brain Tumor Segmentation (BraTS) Challenge 2023: Focus on Pediatrics (CBTN-CONNECT-DIPGR-ASNR-MICCAI BraTS-PEDs)

Author

Kazerooni, Anahita Fathi, Khalili, Nastaran, Liu, Xinyang, Haldar, Debanjan, Jiang, Zhifan, Anwar, Syed Muhammed, Albrecht, Jake, Adewole, Maruf, Anazodo, Udunna, Anderson, Hannah, Bagheri, Sina, Baid, Ujjwal, Bergquist, Timothy, Borja, Austin J., Calabrese, Evan, Chung, Verena, Conte, Gian-Marco, Dako, Farouk, Eddy, James, Ezhov, Ivan, Familiar, Ariana, Farahani, Keyvan, Haldar, Shuvanjan, Iglesias, Juan Eugenio, Janas, Anastasia, Johansen, Elaine, Jones, Blaise V, Kofler, Florian, LaBella, Dominic, Lai, Hollie Anne, Van Leemput, Koen, Li, Hongwei Bran, Maleki, Nazanin, McAllister, Aaron S, Meier, Zeke, Menze, Bjoern, Moawad, Ahmed W, Nandolia, Khanak K, Pavaine, Julija, Piraud, Marie, Poussaint, Tina, Prabhu, Sanjay P, Reitman, Zachary, Rodriguez, Andres, Rudie, Jeffrey D, Sanchez-Montano, Mariana, Shaikh, Ibraheem Salman, Shah, Lubdha M., Sheth, Nakul, Shinohara, Russel Taki, Tu, Wenxin, Viswanathan, Karthik, Wang, Chunhao, Ware, Jeffrey B, Wiestler, Benedikt, Wiggins, Walter, Zapaishchykova, Anna, Aboian, Mariam, Bornhorst, Miriam, de Blank, Peter, Deutsch, Michelle, Fouladi, Maryam, Hoffman, Lindsey, Kann, Benjamin, Lazow, Margot, Mikael, Leonie, Nabavizadeh, Ali, Packer, Roger, Resnick, Adam, Rood, Brian, Vossough, Arastoo, Bakas, Spyridon, and Linguraru, Marius George

Subjects
Electrical Engineering and Systems Science - Image and Video Processing, Computer Science - Computer Vision and Pattern Recognition, Computer Science - Machine Learning, Quantitative Biology - Quantitative Methods
Abstract

Pediatric tumors of the central nervous system are the most common cause of cancer-related death in children. The five-year survival rate for high-grade gliomas in children is less than 20\%. Due to their rarity, the diagnosis of these entities is often delayed, their treatment is mainly based on historic treatment concepts, and clinical trials require multi-institutional collaborations. The MICCAI Brain Tumor Segmentation (BraTS) Challenge is a landmark community benchmark event with a successful history of 12 years of resource creation for the segmentation and analysis of adult glioma. Here we present the CBTN-CONNECT-DIPGR-ASNR-MICCAI BraTS-PEDs 2023 challenge, which represents the first BraTS challenge focused on pediatric brain tumors with data acquired across multiple international consortia dedicated to pediatric neuro-oncology and clinical trials. The BraTS-PEDs 2023 challenge focuses on benchmarking the development of volumentric segmentation algorithms for pediatric brain glioma through standardized quantitative performance evaluation metrics utilized across the BraTS 2023 cluster of challenges. Models gaining knowledge from the BraTS-PEDs multi-parametric structural MRI (mpMRI) training data will be evaluated on separate validation and unseen test mpMRI dataof high-grade pediatric glioma. The CBTN-CONNECT-DIPGR-ASNR-MICCAI BraTS-PEDs 2023 challenge brings together clinicians and AI/imaging scientists to lead to faster development of automated segmentation techniques that could benefit clinical trials, and ultimately the care of children with brain tumors.

Published
2023

4. Consensus guidelines for the diagnosis and management of isolated sulfite oxidase deficiency and molybdenum cofactor deficiencies

Author

Schwahn, Bernd C., primary, van Spronsen, Francjan, additional, Misko, Albert, additional, Pavaine, Julija, additional, Holmes, Victoria, additional, Spiegel, Ronen, additional, Schwarz, Guenter, additional, Wong, Flora, additional, Horman, Alistair, additional, Pitt, James, additional, Sass, Jörn Oliver, additional, and Lubout, Charlotte, additional

Published
2024
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5. Electroclinical features of MEF2C haploinsufficiency-related epilepsy: A multicenter European study

Author

Raviglione, Federico, Douzgou, Sofia, Scala, Marcello, Mingarelli, Alessia, D'Arrigo, Stefano, Freri, Elena, Darra, Francesca, Giglio, Sabrina, Bonaglia, Maria C, Pantaleoni, Chiara, Mastrangelo, Massimo, Epifanio, Roberta, Elia, Maurizio, Saletti, Veronica, Morlino, Silvia, Vari, Maria Stella, De Liso, Paola, Pavaine, Julija, Spaccini, Luigina, Cattaneo, Elisa, Gardella, Elena, Møller, Rikke S, Marchese, Francesca, Colonna, Clara, Gandioli, Claudia, Gobbi, Giuseppe, Ram, Dipak, Palumbo, Orazio, Carella, Massimo, Germano, Michele, Tonduti, Davide, De Angelis, Diego, Caputo, Davide, Bergonzini, Patrizia, Novara, Francesca, Zuffardi, Orsetta, Verrotti, Alberto, Orsini, Alessandro, Bonuccelli, Alice, De Muto, Maria Carmela, Trivisano, Marina, Vigevano, Federico, Granata, Tiziana, Bernardina, Bernardo Dalla, Tranchina, Antonia, and Striano, Pasquale

Published
2021
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6. Consensus guidelines for the diagnosis and management of isolated sulfite oxidase deficiency and molybdenum cofactor deficiencies

Author

Schwahn, Bernd C., van Spronsen, Francjan, Misko, Albert, Pavaine, Julija, Holmes, Victoria, Spiegel, Ronen, Schwarz, Guenter, Wong, Flora, Horman, Alistair, Pitt, James, Sass, Jörn Oliver, Lubout, Charlotte, Schwahn, Bernd C., van Spronsen, Francjan, Misko, Albert, Pavaine, Julija, Holmes, Victoria, Spiegel, Ronen, Schwarz, Guenter, Wong, Flora, Horman, Alistair, Pitt, James, Sass, Jörn Oliver, and Lubout, Charlotte

Abstract

Sulfite intoxication is the hallmark of four ultrarare disorders that are caused by impaired sulfite oxidase activity due to genetic defects in the synthesis of the molybdenum cofactor or of the apoenzyme sulfite oxidase. Delays on the diagnosis of these disorders are common and have been caused by their unspecific presentation of acute neonatal encephalopathy with high early mortality, followed by the evolution of dystonic cerebral palsy and also by the lack of easily available and reliable diagnostic tests. There is significant variation in survival and in the quality of symptomatic management of affected children. One of the four disorders, molybdenum cofactor deficiency type A (MoCD-A) has recently become amenable to causal treatment with synthetic cPMP (fosdenopterin). The evidence base for the rational use of cPMP is very limited. This prompted the formulation of these clinical guidelines to facilitate diagnosis and support the management of patients. The guidelines were developed by experts in diagnosis and treatment of sulfite intoxication disorders. It reflects expert consensus opinion and evidence from a systematic literature search.

Published
2024

9. Anticipatory banking of samples enables diagnosis of adenylosuccinase deficiency following molecular autopsy in an infant with vacuolating leukoencephalopathy

Author

Sitaram, Spatikha, primary, Banka, Hetalika C., additional, Vassallo, Grace, additional, Pavaine, Julija, additional, Fairclough, Adele, additional, Wright, Ronnie, additional, Fairbanks, Lynette, additional, Bierau, Jörgen, additional, Bowden, Lydia, additional, Schwahn, Bernd, additional, Horman, Alistair, additional, and Banka, Siddharth, additional

Published
2022
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10. Anticipatory banking of samples enables diagnosis of adenylosuccinase deficiency following molecular autopsy in an infant with vacuolating leukoencephalopathy.

Author

Sitaram, Spatikha, Banka, Hetalika C., Vassallo, Grace, Pavaine, Julija, Fairclough, Adele, Wright, Ronnie, Fairbanks, Lynette, Bierau, Jörgen, Bowden, Lydia, Schwahn, Bernd, Horman, Alistair, and Banka, Siddharth

Abstract

Adenylosuccinase deficiency is a rare inborn error of metabolism. We present a newborn who died at 52 days of age with clinical features suggestive of severe epileptic encephalopathy and leukodystrophy of unknown cause. Post‐mortem examination showed an unusual vacuolar appearance of the brain. A molecular autopsy performed via singleton clinical exome analysis revealed a known pathogenic and a variant of uncertain significance in ADSL that encodes adenylosuccinase. Tests on previously stored plasma samples showed elevated succinyladenosine and succinylaminoimidazole carboxamide riboside levels. Adenylosuccinase activity in stored fibroblasts was only ~5% of control confirming the diagnosis of adenylosuccinase deficiency in the child. The parents opted for a chorionic villus biopsy in a subsequent pregnancy and had a child unaffected by adenylosuccinase deficiency. This report adds vacuolating leukodystrophy as a novel feature of adenylosuccinase deficiency and shows the power of biochemical investigations directed by genomic studies to achieve accurate diagnosis. Importantly, this case demonstrates the importance of anticipatory banking of biological samples for reverse biochemical phenotyping in individuals with undiagnosed disorders who may not survive. [ABSTRACT FROM AUTHOR]

Published
2023
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11. Neuroimaging manifestations in children with SARS-CoV-2 infection: a multinational, multicentre collaborative study

Author

Lindan, Camilla E, primary, Mankad, Kshitij, additional, Ram, Dipak, additional, Kociolek, Larry K, additional, Silvera, V Michelle, additional, Boddaert, Nathalie, additional, Stivaros, Stavros Michael, additional, Palasis, Susan, additional, Akhtar, Sameen, additional, Alden, Douglas, additional, Amonkar, Suraj, additional, Aouad, Pascale, additional, Aubart, Mélodie, additional, Bacalla, Jose Alejandro, additional, Barbosa, Alcino A, additional, Basmaci, Romain, additional, Berteloot, Laureline, additional, Blauwblomme, Thomas, additional, Brun, Gilles, additional, Carney, Olivia, additional, Chareyre, Judith, additional, Chéron, Gérard, additional, Coimbra, Pablo Picasso De Araujo, additional, Dangouloff-Ros, Volodia, additional, D'Arco, Felice, additional, Dineen, Rob, additional, De-Pontual, Loic, additional, Desguerre, Isabelle, additional, Elfallal, Wissam, additional, Evans, D. Gareth, additional, Ferraciolli, Suely Fazio, additional, Girard, Nadine, additional, Gonçalves, Fabrício Guimarães, additional, Gonzalez, Ivan, additional, Grant, P. Ellen, additional, Grévent, David, additional, Guimaraes, Carolina Valduga de Alencastro, additional, Hassell, Jane, additional, Hirata, Fabiana C.C., additional, Kamaly-Asl, Ian, additional, Jacob, Jeffrey, additional, Jackson, Kandise, additional, Jones, Blaise V., additional, Joseph, Robin, additional, Jung, Ah Young, additional, Kashgari, Amna, additional, Kilday, John-Paul, additional, Kirsch, Alyssa, additional, Kossorotoff, Manoelle, additional, Krishnan, Anant, additional, Kulkarni, Shilpa, additional, Leruez-Vill, Marianne, additional, Lesage, Fabrice, additional, Levy, Raphaël, additional, Li, Yi, additional, Lima, Carol Cavalcante de Vasconcelos, additional, Lingappa, Lokesh, additional, Löbel, Ulrike, additional, Lopez-Alberola, Roberto, additional, Lucato, Leandro Tavares, additional, Moreira, Daniela Duarte, additional, Murnick, Jonathan G., additional, Nahmani, Sarah, additional, Pagariya, Shubra, additional, Pavaine, Julija, additional, Philbrook, Bryan, additional, Piovesan, Ana Cláudia, additional, Poisson, Kelsey E., additional, Reddy, Nihaal, additional, Riley, Phil, additional, Romsauerova, Andrea, additional, Roux, Charlies-Joris, additional, Rugilo, Carlos, additional, Saigal, Gaurav, additional, Salvador, Gabriel Lucca de Oliveira, additional, Seidenwurm, David, additional, Sermet-Gaudelus, Isabelle, additional, Sidpra, Jai, additional, Sudhakar, Sniya Valsa, additional, Toronchik, María Sol, additional, and Vézina, Gilbert, additional

Published
2021
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14. Pathogenic Bi-allelic Mutations in NDUFAF8 Cause Leigh Syndrome with an Isolated Complex I Deficiency

Author

Alston, Charlotte L., primary, Veling, Mike T., additional, Heidler, Juliana, additional, Taylor, Lucie S., additional, Alaimo, Joseph T., additional, Sung, Andrew Y., additional, He, Langping, additional, Hopton, Sila, additional, Broomfield, Alexander, additional, Pavaine, Julija, additional, Diaz, Jullianne, additional, Leon, Eyby, additional, Wolf, Philipp, additional, McFarland, Robert, additional, Prokisch, Holger, additional, Wortmann, Saskia B., additional, Bonnen, Penelope E., additional, Wittig, Ilka, additional, Pagliarini, David J., additional, and Taylor, Robert W., additional

Published
2020
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15. Severe type I interferonopathy and unrestrained interferon signaling due to a homozygous germline mutation in STAT2

Author

Duncan, Christopher J. A., primary, Thompson, Benjamin J., additional, Chen, Rui, additional, Rice, Gillian I., additional, Gothe, Florian, additional, Young, Dan F., additional, Lovell, Simon C., additional, Shuttleworth, Victoria G., additional, Brocklebank, Vicky, additional, Corner, Bronte, additional, Skelton, Andrew J., additional, Bondet, Vincent, additional, Coxhead, Jonathan, additional, Duffy, Darragh, additional, Fourrage, Cecile, additional, Livingston, John H., additional, Pavaine, Julija, additional, Cheesman, Edmund, additional, Bitetti, Stephania, additional, Grainger, Angela, additional, Acres, Meghan, additional, Innes, Barbara A., additional, Mikulasova, Aneta, additional, Sun, Ruyue, additional, Hussain, Rafiqul, additional, Wright, Ronnie, additional, Wynn, Robert, additional, Zarhrate, Mohammed, additional, Zeef, Leo A. H., additional, Wood, Katrina, additional, Hughes, Stephen M., additional, Harris, Claire L., additional, Engelhardt, Karin R., additional, Crow, Yanick J., additional, Randall, Richard E., additional, Kavanagh, David, additional, Hambleton, Sophie, additional, and Briggs, Tracy A., additional

Published
2019
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16. Pathogenic bi-allelic mutations in NDUFAF8 cause Leigh syndrome with an isolated complex I deficiency

Author

Alston, Charlotte L., Veling, Mike T., Heidler, Juliana, Taylor, Lucie S., Alaimo, Joseph T., Sung, Andrew Y., He, Langping, Hopton, Sila, Broomfield, Alexander, Pavaine, Julija, Diaz, Jullianne, Leon, Eyby, Wolf, Philipp, McFarland, Robert, Prokisch, Holger, Wortmann, Saskia B., Bonnen, Penelope E., Wittig, Ilka, Pagliarini, David J., Taylor, Robert W., Alston, Charlotte L., Veling, Mike T., Heidler, Juliana, Taylor, Lucie S., Alaimo, Joseph T., Sung, Andrew Y., He, Langping, Hopton, Sila, Broomfield, Alexander, Pavaine, Julija, Diaz, Jullianne, Leon, Eyby, Wolf, Philipp, McFarland, Robert, Prokisch, Holger, Wortmann, Saskia B., Bonnen, Penelope E., Wittig, Ilka, Pagliarini, David J., and Taylor, Robert W.

Abstract

Leigh syndrome is one of the most common neurological phenotypes observed in pediatric mitochondrial disease presentations. It is characterized by symmetrical lesions found on neuroimaging in the basal ganglia, thalamus, and brainstem and by a loss of motor skills and delayed developmental milestones. Genetic diagnosis of Leigh syndrome is complicated on account of the vast genetic heterogeneity with >75 candidate disease-associated genes having been reported to date. Candidate genes are still emerging, being identified when “omics” tools (genomics, proteomics, and transcriptomics) are applied to manipulated cell lines and cohorts of clinically characterized individuals who lack a genetic diagnosis. NDUFAF8 is one such protein; it has been found to interact with the well-characterized complex I (CI) assembly factor NDUFAF5 in a large-scale protein-protein interaction screen. Diagnostic next-generation sequencing has identified three unrelated pediatric subjects, each with a clinical diagnosis of Leigh syndrome, who harbor bi-allelic pathogenic variants in NDUFAF8. These variants include a recurrent splicing variant that was initially overlooked due to its deep-intronic location. Subject fibroblasts were found to express a complex I deficiency, and lentiviral transduction with wild-type NDUFAF8-cDNA ameliorated both the assembly defect and the biochemical deficiency. Complexome profiling of subject fibroblasts demonstrated a complex I assembly defect, and the stalled assembly intermediates corroborate the role of NDUFAF8 in early complex I assembly. This report serves to expand the genetic heterogeneity associated with Leigh syndrome and to validate the clinical utility of orphan protein characterization. We also highlight the importance of evaluating intronic sequence when a single, definitively pathogenic variant is identified during diagnostic testing.

Published
2019

18. The Brain Tumor Segmentation (BraTS) Challenge 2023: Focus on Pediatrics (CBTN-CONNECT-DIPGR-ASNR-MICCAI BraTS-PEDs) .

Author

Kazerooni AF, Khalili N, Liu X, Haldar D, Jiang Z, Anwar SM, Albrecht J, Adewole M, Anazodo U, Anderson H, Bagheri S, Baid U, Bergquist T, Borja AJ, Calabrese E, Chung V, Conte GM, Dako F, Eddy J, Ezhov I, Familiar A, Farahani K, Haldar S, Iglesias JE, Janas A, Johansen E, Jones BV, Kofler F, LaBella D, Lai HA, Van Leemput K, Li HB, Maleki N, McAllister AS, Meier Z, Menze B, Moawad AW, Nandolia KK, Pavaine J, Piraud M, Poussaint T, Prabhu SP, Reitman Z, Rodriguez A, Rudie JD, Shaikh IS, Shah LM, Sheth N, Shinohara RT, Tu W, Viswanathan K, Wang C, Ware JB, Wiestler B, Wiggins W, Zapaishchykova A, Aboian M, Bornhorst M, de Blank P, Deutsch M, Fouladi M, Hoffman L, Kann B, Lazow M, Mikael L, Nabavizadeh A, Packer R, Resnick A, Rood B, Vossough A, Bakas S, and Linguraru MG

Abstract

Pediatric tumors of the central nervous system are the most common cause of cancer-related death in children. The five-year survival rate for high-grade gliomas in children is less than 20%. Due to their rarity, the diagnosis of these entities is often delayed, their treatment is mainly based on historic treatment concepts, and clinical trials require multi-institutional collaborations. The MICCAI Brain Tumor Segmentation (BraTS) Challenge is a landmark community benchmark event with a successful history of 12 years of resource creation for the segmentation and analysis of adult glioma. Here we present the CBTN-CONNECT-DIPGR-ASNR-MICCAI BraTS-PEDs 2023 challenge, which represents the first BraTS challenge focused on pediatric brain tumors with data acquired across multiple international consortia dedicated to pediatric neuro-oncology and clinical trials. The BraTS-PEDs 2023 challenge focuses on benchmarking the development of volumentric segmentation algorithms for pediatric brain glioma through standardized quantitative performance evaluation metrics utilized across the BraTS 2023 cluster of challenges. Models gaining knowledge from the BraTS-PEDs multi-parametric structural MRI (mpMRI) training data will be evaluated on separate validation and unseen test mpMRI dataof high-grade pediatric glioma. The CBTN-CONNECT-DIPGR-ASNR-MICCAI BraTS-PEDs 2023 challenge brings together clinicians and AI/imaging scientists to lead to faster development of automated segmentation techniques that could benefit clinical trials, and ultimately the care of children with brain tumors.

Published
2024

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