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3. Increase of nitrous oxide-induced neurological disorders – a German multicenter experience.

Author

Meißner, Julius Nicolai, Neuneier, Janina, Bartzokis, Iason, Rehm, Mathias, Al-Hayali, Ahmad, Müller, Marcus, Paus, Sebastian, Limmroth, Volker, Fink, Gereon R., Petzold, Gabor C., and Nitsch, Louisa

Subjects
MEDICAL sciences, NEUROLOGICAL disorders, CONSCIOUSNESS raising, SYMPTOMS, NEUROPATHY
Abstract

Background: Nitrous oxide (N₂O), commonly known as laughing gas, is widely recognized for its anesthetic and analgesic effects, and is frequently used in medical contexts. However, its misuse can lead to significant neurological complications, which are often under-recognized in clinical practice. Recent data on such cases in Germany are rare. We here report the spectrum of neurological complications associated with the recreational use of N₂O, as encountered in German neurology centers. Methods: We retrospectively analyzed of 23 cases presenting with neurological symptoms following N₂O abuse between July 2020 and August 2024 across five neurology departments in Germany. Data were collected on patient demographics, clinical manifestations, diagnostic findings, and treatment approaches. Results: Over the last four years the number of cases increased. Clinical presentations primarily included neuropathy, found in all patients, along with myelopathy. The most common symptoms were sensory loss, ataxia, and motor deficits. Conclusion: Our data suggest that N₂O abuse is on the rise in Germany. Further initiatives are warranted to raise awareness among users, healthcare and professionals. [ABSTRACT FROM AUTHOR]

Published
2025
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6. Botulinum neurotoxin type A in the interdisciplinary treatment of sialorrhea in adults and children—update and practice recommendations

Author

Jost, Wolfgang H., primary, Bäumer, Tobias, additional, Bevot, Andrea, additional, Birkmann, Ulrich, additional, Buhmann, Carsten, additional, Grosheva, Maria, additional, Guntinas-Lichius, Orlando, additional, Laskawi, Rainer, additional, Paus, Sebastian, additional, Pflug, Christina, additional, Schroeder, A. Sebastian, additional, Spittau, Björn, additional, Steffen, Armin, additional, Wilken, Bernd, additional, Winterholler, Martin, additional, and Berweck, Steffen, additional

Published
2023
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9. Defining spasticity: a new approach considering current movement disorders terminology and botulinum toxin therapy

Author

Dressler, Dirk, Bhidayasiri, Roongroj, Bohlega, Saeed, Chana, Pedro, Chien, Hsin Fen, Chung, Tae Mo, Colosimo, Carlo, Ebke, Markus, Fedoroff, Klemens, Frank, Bernd, Kaji, Ryuji, Kanovsky, Petr, Koçer, Serdar, Micheli, Federico, Orlova, Olga, Paus, Sebastian, Pirtosek, Zvezdan, Relja, Maja, Rosales, Raymond L., Sagástegui-Rodríguez, José Alberto, Schoenle, Paul W., Shahidi, Gholam Ali, Timerbaeva, Sofia, Walter, Uwe, and Saberi, Fereshte Adib

Published
2018
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11. Botulinum toxin therapy for treatment of spasticity in multiple sclerosis: review and recommendations of the IAB-Interdisciplinary Working Group for Movement Disorders task force

Author

Dressler, Dirk, Bhidayasiri, Roongroj, Bohlega, Saeed, Chahidi, Abderrahmane, Chung, Tae Mo, Ebke, Markus, Jacinto, L. Jorge, Kaji, Ryuji, Koçer, Serdar, Kanovsky, Petr, Micheli, Federico, Orlova, Olga, Paus, Sebastian, Pirtosek, Zvezdan, Relja, Maja, Rosales, Raymond L., Sagástegui-Rodríguez, José Alberto, Schoenle, Paul W., Shahidi, Gholam Ali, Timerbaeva, Sofia, Walter, Uwe, and Saberi, Fereshte Adib

Published
2017
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14. Aneurysmal Subarachnoid Hemorrhage during the Shutdown for COVID-19

Author

Güresir, Erdem, primary, Gräff, Ingo, additional, Seidel, Matthias, additional, Bauer, Hartmut, additional, Coch, Christoph, additional, Diepenseifen, Christian, additional, Dohmen, Christian, additional, Engels, Susanne, additional, Hadjiathanasiou, Alexis, additional, Heister, Ulrich, additional, Heyer, Inge, additional, Lampmann, Tim, additional, Paus, Sebastian, additional, Petzold, Gabor, additional, Pöhlau, Dieter, additional, Putensen, Christian, additional, Schneider, Matthias, additional, Schuss, Patrick, additional, Textor, Jochen, additional, Velten, Markus, additional, Wach, Johannes, additional, Welchowski, Thomas, additional, and Vatter, Hartmut, additional

Published
2022
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15. Erratum: Behandlung der Sialorrhoe mit Botulinum Neurotoxin Typ A – Konsentierte Praxisempfehlungen für Kinder und Erwachsene

Author

Jost, Wolfgang H., additional, Bäumer, Tobias, additional, Bevot, Andrea, additional, Birkmann, Ulrich, additional, Buhmann, Carsten, additional, Grosheva, Maria, additional, Guntinas-Lichius, Orlando, additional, Mlynczak, Ute, additional, Paus, Sebastian, additional, Pflug, Christina, additional, Schröder, Sebastian, additional, Steffen, Armin, additional, Wilken, Bernd, additional, and Berweck, Steffen, additional

Published
2022
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16. Treatment of Sialorrhea with Botulinum Neurotoxin Type A - Consensus Practice Recommendations for Children and Adults

Author

Jost, Wolfgang H., Baeumer, Tobias, Bevot, Andrea, Birkmann, Ulrich, Buhmann, Carsten, Grosheva, Maria, Guntinas-Lichius, Orlando, Mlynczak, Ute, Paus, Sebastian, Pflug, Christina, Schroeder, Sebastian, Steffen, Armin, Wilken, Bernd, Berweck, Steffen, Jost, Wolfgang H., Baeumer, Tobias, Bevot, Andrea, Birkmann, Ulrich, Buhmann, Carsten, Grosheva, Maria, Guntinas-Lichius, Orlando, Mlynczak, Ute, Paus, Sebastian, Pflug, Christina, Schroeder, Sebastian, Steffen, Armin, Wilken, Bernd, and Berweck, Steffen

Abstract

Sialorrhea, uncontrolled, excessive drooling, accompanies different, mostly neurological disorders from childhood to adulthood. With incobotulinumtoxinA(Xeomin, IncoBoNT/A, Merz Pharmaceuticals GmbH), an approved medication for the treatment of sialorrhea has been available since 2019. Patient selection, possible therapy goals, treatment and the management of specific treatment situations build the focus of this interdisciplinary expert consensus recommendations with the intent to facilitate access to treatment and to contribute to qualified botulinum toxin therapy.

Published
2022

17. Behandlung der Sialorrhoe mit Botulinum Neurotoxin Typ A – Konsentierte Praxisempfehlungen für Kinder und Erwachsene

Author

Jost, Wolfgang H., additional, Bäumer, Tobias, additional, Bevot, Andrea, additional, Birkmann, Ulrich, additional, Buhmann, Carsten, additional, Grosheva, Maria, additional, Guntinas-Lichius, Orlando, additional, Mlynczak, Ute, additional, Paus, Sebastian, additional, Pflug, Christina, additional, Schröder, Sebastian, additional, Steffen, Armin, additional, Wilken, Bernd, additional, and Berweck, Steffen, additional

Published
2022
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19. Transcript-Specific Loss-of-Function Variants in VPS16 Are Enriched in Patients With Dystonia

Author

Park, Joohyun, primary, Reilaender, Annemarie, additional, Petry-Schmelzer, Jan N., additional, Stöbe, Petra, additional, Cordts, Isabell, additional, Harmuth, Florian, additional, Rautenberg, Maren, additional, Woerz, Sarah E., additional, Demidov, German, additional, Sturm, Marc, additional, Ossowski, Stephan, additional, Schwaibold, Eva M.C., additional, Wunderlich, Gilbert, additional, Paus, Sebastian, additional, Saft, Carsten, additional, and Haack, Tobias B., additional

Published
2021
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20. Long-term efficacy and safety of incobotulinumtoxinA injections in patients with cervical dystonia

Author

Dressler, Dirk, Paus, Sebastian, Seitzinger, Andrea, Gebhardt, Bernd, Kupsch, Andreas, Bock, Ute, Ceballos-Baumann, Andres, Dengler, Reinhard, Ebke, Markus, Hagenah, Johann, Haslinger, Bernhard, Hecht, Martin, Heide, Guenther, Hellwig, Sabine, Kupsch, Andreas, Paus, Sebastian, Schiefer, Johannes, Storch, Alexander, Vieregge, Peter, Vogt, Thomas, Volkmann, Jens, and Woldag, Hartwig

Published
2013
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32. Acute Hebephrenia

Author

Paus, Sebastian, Urbach, Horst, Klockgether, Thomas, and Hartmann, Alexander

Published
2005

36. CASE STUDY: Hand-Held Device Coats Pipeline Field Joints to OEM-Standards

Author

Paus, Sebastian

Subjects
Pipelines -- Case studies, Technology, Business, Petroleum, energy and mining industries
Abstract

Tape wrap contends with higher technology pipeline joint coating solutions, in many contexts with a degree of success. Wrapped with skill, tape can offer the requisite protection a pipeline joint [...]

Published
2019

38. Evidenz von Botulinum (BoNT-A) bei Depressionen: Botulinumtoxin A-Antifaltenbehandlung ist antidepressiv wirksam.

Author

CONRAD, DAVID, RAULIN, CHRISTIAN, POLSTER, WERNER, and PAUS, SEBASTIAN

Abstract

Copyright of Kosmetische Medizin + Ästhetische Chirurgie is the property of gmc-Gesundheitsmedien & Congress GmbH and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2020

40. Zervikale Dystonien

Author

Reichel, Gerhard, additional, Kamm, Christoph, additional, Kang, Jun Suk, additional, Müngersdorf, Martina, additional, Paus, Sebastian, additional, Reuter, Iris, additional, Stenner, Andrea, additional, and Weise, David, additional

Published
2018
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43. Depression in blepharospasm: a question of facial feedback?

Author

Bedarf,Janis Rebecca, Kebir,Sied, Michelis,Joan Philipp, Wabbels,Bettina, Paus,Sebastian, Bedarf,Janis Rebecca, Kebir,Sied, Michelis,Joan Philipp, Wabbels,Bettina, and Paus,Sebastian

Abstract

Janis Rebecca Bedarf,1 Sied Kebir,1,2 Joan Philipp Michelis,1,3 Bettina Wabbels,4 Sebastian Paus1 1Department of Neurology, University of Bonn, Bonn, 2Department of Neurology, University of Essen, Essen, Germany; 3Movement Disorders Center, Department of Neurology, Bern University Hospital, Bern, Switzerland; 4Department of Ophthalmology, University of Bonn, Bonn, Germany Abstract: Depression is the most important nonmotor symptom in blepharospasm (BL). As facial expression influences emotional perception, summarized as the facial feedback hypothesis, we investigated if patients report fewer depressive symptoms if injections of botulinum neurotoxin (BoNT) include the “grief muscles” of the glabellar region, compared to treatment of orbicularis oculi muscles alone. Ninety BL patients were included, half of whom had BoNT treatment including the frown lines. While treatment pattern did not predict depressive symptoms overall, subgroup analysis revealed that in male BL patients, BoNT injections into the frown lines were associated with remarkably less depressive symptoms. We hypothesize that in BL patients presenting with dystonia of the eyebrow region, BoNT therapy should include frown line application whenever justified, to optimize nonmotor effects of BoNT denervation. Keywords: botulinum neurotoxin, blepharospasm, depression, facial feedback, frown lines, grief muscles

Published
2017

44. Botulinum toxin therapy for treatment of spasticity in multiple sclerosis: review and recommendations of the IAB-Interdisciplinary Working Group for Movement Disorders task force

Author

Dressler, Dirk, primary, Bhidayasiri, Roongroj, additional, Bohlega, Saeed, additional, Chahidi, Abderrahmane, additional, Chung, Tae Mo, additional, Ebke, Markus, additional, Jacinto, L. Jorge, additional, Kaji, Ryuji, additional, Koçer, Serdar, additional, Kanovsky, Petr, additional, Micheli, Federico, additional, Orlova, Olga, additional, Paus, Sebastian, additional, Pirtosek, Zvezdan, additional, Relja, Maja, additional, Rosales, Raymond L., additional, Sagástegui-Rodríguez, José Alberto, additional, Schoenle, Paul W., additional, Shahidi, Gholam Ali, additional, Timerbaeva, Sofia, additional, Walter, Uwe, additional, and Saberi, Fereshte Adib, additional

Published
2016
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46. Sexual dysfunction in cervical dystonia and blepharospasm.

Author

Marek, Milena, Grobe-Einsler, Marcus, Bedarf, Janis Rebecca, Wabbels, Bettina, and Paus, Sebastian

Subjects
SEXUAL dysfunction, BLEPHAROSPASM, DYSTONIA, MENTAL depression, PARKINSON'S disease
Abstract

Background: Sexual dysfunction is a frequent, yet underrated, symptom of neurological disease. While knowledge of non-motor comorbidity in focal dystonia is growing rapidly, there is no information on the prevalence of sexual dysfunction in cervical dystonia (CD) or blepharospasm (BL). Methods: In this controlled study, we examined sexual dysfunction in 65 patients with CD and 54 patients with BL by the Arizona Sexual Experience Scale, a validated self-rating scale. Results: Sexual dysfunction was significantly higher in CD patients (45%) than in controls (24%), and frequent in BL (39%). Interestingly, variables of dystonia such as disease duration or severity did not influence sexuality; yet, 23% of CD patients ascribed worsening of their sexual life to dystonia. Symptoms of depression were identified as the most important predictors for sexual dysfunction, followed by age, and personal status (single). Conclusion: Our observations establish sexual dysfunction as a frequent non-motor symptom in CD and BL that is perceived as a burden. It should be considered when investigating patients with adult-onset focal dystonia. [ABSTRACT FROM AUTHOR]

Published
2018
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