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3. Nöropsikofarmakolojide Terapötik İla ç İzlemi İ çin Ortak Görü ş Kılavuzu: 2017 G üncellemesi

Author

Hiemke, C., Bergemann, N., Clement, H. W., Conca, A., Deckert, J., Domschke, K., Eckermann, G., Egberts, K., Gerlach, M., Greiner, C., Grunder, G., Haen, E., Havemann-Reinecke, U., Hefner, G., Helmer, R., Janssen, G., Jaquenoud, E., Laux, G., Messer, T., Mossner, R., Muller, M. J., Paulzen, M., Pfuhlmann, B., Riederer, P., Saria, A., Schoppek, B., Schoretsanitis, G., Schwarz, M., Gracia, M. S., Stegmann, B., Steimer, W., Stingl, J. C., Uhr, M., Ulrich, S., Unterecker, S., Waschgler, R., Zernig, G., Zurek, G., Baumann, P., Hiemke, C., Bergemann, N., Clement, H. W., Conca, A., Deckert, J., Domschke, K., Eckermann, G., Egberts, K., Gerlach, M., Greiner, C., Grunder, G., Haen, E., Havemann-Reinecke, U., Hefner, G., Helmer, R., Janssen, G., Jaquenoud, E., Laux, G., Messer, T., Mossner, R., Muller, M. J., Paulzen, M., Pfuhlmann, B., Riederer, P., Saria, A., Schoppek, B., Schoretsanitis, G., Schwarz, M., Gracia, M. S., Stegmann, B., Steimer, W., Stingl, J. C., Uhr, M., Ulrich, S., Unterecker, S., Waschgler, R., Zernig, G., Zurek, G., and Baumann, P.

Published
2024

12. Antidopaminergic medication in healthy subjects provokes subjective and objective mental impairments tightly correlated with perturbation of biogenic monoamine metabolism and prolactin secretion

Author

Veselinović T, Vernaleken I, Cumming P, Henning U, Winkler L, Kaleta P, Paulzen M, Luckhaus C, and Gründer G

Subjects
catecholamine metabolites, HVA, prolactin, dopamine, reserpine, aripiprazole, haloperidol, off-label prescription, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract

Tanja Veselinović,1,2 Ingo Vernaleken,1,2 Paul Cumming,3,4 Uwe Henning,5 Lina Winkler,1,2 Peter Kaleta,1,2 Michael Paulzen,1,2 Christian Luckhaus,6 Gerhard Gründer1,2,7 1Department of Psychiatry, Psychotherapy, and Psychosomatics, Faculty of Medicine, RWTH Aachen University, Aachen, 2Translational Brain Medicine, Jülich Aachen Research Alliance (JARA), Jülich, Germany; 3IHBI, School of Psychology and Counselling, Queensland University of Technology, 4QIMR Berghofer Institute, Brisbane, Australia; 5Neurobiochemical Research Unit, Department of Psychiatry, Heinrich Heine University, Düsseldorf, 6LWL University Hospital Bochum, Department of Psychiatry, Division of Cognitive Neuropsychiatry and Psychiatric Preventive Medicine, Ruhr University Bochum, Bochum, 7Department of Molecular Neuroimaging, Central Institute of Mental Health, Mannheim, Germany Objectives: Off-label prescription of antipsychotics to patients without psychotic symptoms has become a routine matter for many psychiatrists and also some general practitioners. Nonetheless, little is known about the possibly detrimental effects of antidopaminergic medications on general psychopathology, subjective mental state, or a possible association with physiological parameters in nonpsychotic individuals.Methods: In this randomized, single-blinded study, groups of healthy volunteers (n=18) received low doses of reserpine, aripiprazole, haloperidol, or placebo on 7 successive days. Relevant physiological parameters (plasma prolactin, concentrations of catecholamine metabolites in plasma, and 24-hour urine) and each subject’s mental state (Positive and Negative Syndrome Scale, Hamilton Rating Scale for Depression, visual analogue scale, Beck Depression Inventory II) were assessed at the start and end of the trial.Results: Of the three active treatments, only reserpine caused a significant increase in some plasma- and urine-catecholamine metabolites, but all three medications evoked objective and subjective changes in general psychopathology scores, which correlated with individual increases in plasma homovanillic acid concentrations. Both objective and subjective impairments were significantly more pronounced in the subgroup with greatest increase of plasma prolactin. Subjects experiencing the most pronounced side effects under haloperidol, which compelled them to drop out, showed significantly higher prolactin concentration increases than those who tolerated haloperidol well.Conclusion: We found consistent associations between altered markers of dopamine transmission and several objective and subjective mental impairments in healthy volunteers after 1 week’s treatment with antidopaminergic medications. These findings should draw attention to a more intensive risk–benefit evaluation in cases of off-label prescription of antipsychotic medications. Keywords: catecholamine metabolites, HVA, prolactin, dopamine, reserpine, aripiprazole, haloperidol, off-label prescription

Published
2018

16. Pocket Guide Psychopharmaka von A bis Z

Author

Benkert, Otto, primary, Anghelescu, I.-G., additional, Gründer, G., additional, Heiser, P., additional, Hiemke, C., additional, Himmerich, H., additional, Kiefer, F., additional, Lange-Asschenfeldt, C., additional, Müller, M. J., additional, Paulzen, M., additional, Regen, F., additional, Steiger, A., additional, and Weber, F., additional

Published
2019
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17. Bupropion

Author

Benkert, Otto, Anghelescu, Ion, Fehr, Christoph, Gründer, Gerhard, Heiser, Philip, Hiemke, Christoph, Lange-Asschenfeldt, Christian, Müller, M. J., Paulzen, M., Regen, Francesca, Steiger, Axel, Benkert, Otto, Anghelescu, Ion, Fehr, Christoph, Gründer, Gerhard, Heiser, Philip, Hiemke, Christoph, Lange-Asschenfeldt, Christian, Müller, M. J., Paulzen, M., Regen, Francesca, and Steiger, Axel

Published
2010
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18. Haloperidol

Author

Benkert, Otto, Anghelescu, Ion, Fehr, Christoph, Gründer, Gerhard, Heiser, Philip, Hiemke, Christoph, Lange-Asschenfeldt, Christian, Müller, M. J., Paulzen, M., Regen, Francesca, Steiger, Axel, Benkert, Otto, Anghelescu, Ion, Fehr, Christoph, Gründer, Gerhard, Heiser, Philip, Hiemke, Christoph, Lange-Asschenfeldt, Christian, Müller, M. J., Paulzen, M., Regen, Francesca, and Steiger, Axel

Published
2010
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19. Clozapin

Author

Benkert, Otto, Anghelescu, Ion, Fehr, Christoph, Gründer, Gerhard, Heiser, Philip, Hiemke, Christoph, Lange-Asschenfeldt, Christian, Müller, M. J., Paulzen, M., Regen, Francesca, Steiger, Axel, Benkert, Otto, Anghelescu, Ion, Fehr, Christoph, Gründer, Gerhard, Heiser, Philip, Hiemke, Christoph, Lange-Asschenfeldt, Christian, Müller, M. J., Paulzen, M., Regen, Francesca, and Steiger, Axel

Published
2010
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20. Valproinsäure

Author

Benkert, Otto, Anghelescu, Ion, Fehr, Christoph, Gründer, Gerhard, Heiser, Philip, Hiemke, Christoph, Lange-Asschenfeldt, Christian, Müller, M. J., Paulzen, M., Regen, Francesca, Steiger, Axel, Benkert, Otto, Anghelescu, Ion, Fehr, Christoph, Gründer, Gerhard, Heiser, Philip, Hiemke, Christoph, Lange-Asschenfeldt, Christian, Müller, M. J., Paulzen, M., Regen, Francesca, and Steiger, Axel

Published
2010
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21. Risperidon

Author

Benkert, Otto, Anghelescu, Ion, Fehr, Christoph, Gründer, Gerhard, Heiser, Philip, Hiemke, Christoph, Lange-Asschenfeldt, Christian, Müller, M. J., Paulzen, M., Regen, Francesca, Steiger, Axel, Benkert, Otto, Anghelescu, Ion, Fehr, Christoph, Gründer, Gerhard, Heiser, Philip, Hiemke, Christoph, Lange-Asschenfeldt, Christian, Müller, M. J., Paulzen, M., Regen, Francesca, and Steiger, Axel

Published
2010
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22. Quetiapin

Author

Benkert, Otto, Anghelescu, Ion, Fehr, Christoph, Gründer, Gerhard, Heiser, Philip, Hiemke, Christoph, Lange-Asschenfeldt, Christian, Müller, M. J., Paulzen, M., Regen, Francesca, Steiger, Axel, Benkert, Otto, Anghelescu, Ion, Fehr, Christoph, Gründer, Gerhard, Heiser, Philip, Hiemke, Christoph, Lange-Asschenfeldt, Christian, Müller, M. J., Paulzen, M., Regen, Francesca, and Steiger, Axel

Published
2010
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23. Perphenazin

Author

Benkert, Otto, Anghelescu, Ion, Fehr, Christoph, Gründer, Gerhard, Heiser, Philip, Hiemke, Christoph, Lange-Asschenfeldt, Christian, Müller, M. J., Paulzen, M., Regen, Francesca, Steiger, Axel, Benkert, Otto, Anghelescu, Ion, Fehr, Christoph, Gründer, Gerhard, Heiser, Philip, Hiemke, Christoph, Lange-Asschenfeldt, Christian, Müller, M. J., Paulzen, M., Regen, Francesca, and Steiger, Axel

Published
2010
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24. Olanzapin

Author

Benkert, Otto, Anghelescu, Ion, Fehr, Christoph, Gründer, Gerhard, Heiser, Philip, Hiemke, Christoph, Lange-Asschenfeldt, Christian, Müller, M. J., Paulzen, M., Regen, Francesca, Steiger, Axel, Benkert, Otto, Anghelescu, Ion, Fehr, Christoph, Gründer, Gerhard, Heiser, Philip, Hiemke, Christoph, Lange-Asschenfeldt, Christian, Müller, M. J., Paulzen, M., Regen, Francesca, and Steiger, Axel

Published
2010
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25. Methadon

Author

Benkert, Otto, Anghelescu, Ion, Fehr, Christoph, Gründer, Gerhard, Heiser, Philip, Hiemke, Christoph, Lange-Asschenfeldt, Christian, Müller, M. J., Paulzen, M., Regen, Francesca, Steiger, Axel, Benkert, Otto, Anghelescu, Ion, Fehr, Christoph, Gründer, Gerhard, Heiser, Philip, Hiemke, Christoph, Lange-Asschenfeldt, Christian, Müller, M. J., Paulzen, M., Regen, Francesca, and Steiger, Axel

Published
2010
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26. Lithiumsalze

Author

Benkert, Otto, Anghelescu, Ion, Fehr, Christoph, Gründer, Gerhard, Heiser, Philip, Hiemke, Christoph, Lange-Asschenfeldt, Christian, Müller, M. J., Paulzen, M., Regen, Francesca, Steiger, Axel, Benkert, Otto, Anghelescu, Ion, Fehr, Christoph, Gründer, Gerhard, Heiser, Philip, Hiemke, Christoph, Lange-Asschenfeldt, Christian, Müller, M. J., Paulzen, M., Regen, Francesca, and Steiger, Axel

Published
2010
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27. Imipramin

Author

Benkert, Otto, Anghelescu, Ion, Fehr, Christoph, Gründer, Gerhard, Heiser, Philip, Hiemke, Christoph, Lange-Asschenfeldt, Christian, Müller, M. J., Paulzen, M., Regen, Francesca, Steiger, Axel, Benkert, Otto, Anghelescu, Ion, Fehr, Christoph, Gründer, Gerhard, Heiser, Philip, Hiemke, Christoph, Lange-Asschenfeldt, Christian, Müller, M. J., Paulzen, M., Regen, Francesca, and Steiger, Axel

Published
2010
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28. Fluvoxamin

Author

Benkert, Otto, Anghelescu, Ion, Fehr, Christoph, Gründer, Gerhard, Heiser, Philip, Hiemke, Christoph, Lange-Asschenfeldt, Christian, Müller, M. J., Paulzen, M., Regen, Francesca, Steiger, Axel, Benkert, Otto, Anghelescu, Ion, Fehr, Christoph, Gründer, Gerhard, Heiser, Philip, Hiemke, Christoph, Lange-Asschenfeldt, Christian, Müller, M. J., Paulzen, M., Regen, Francesca, and Steiger, Axel

Published
2010
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29. Doxepin

Author

Benkert, Otto, Anghelescu, Ion, Fehr, Christoph, Gründer, Gerhard, Heiser, Philip, Hiemke, Christoph, Lange-Asschenfeldt, Christian, Müller, M. J., Paulzen, M., Regen, Francesca, Steiger, Axel, Benkert, Otto, Anghelescu, Ion, Fehr, Christoph, Gründer, Gerhard, Heiser, Philip, Hiemke, Christoph, Lange-Asschenfeldt, Christian, Müller, M. J., Paulzen, M., Regen, Francesca, and Steiger, Axel

Published
2010
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30. Zuclopenthixol

Author

Benkert, Otto, Anghelescu, Ion, Fehr, Christoph, Gründer, Gerhard, Heiser, Philip, Hiemke, Christoph, Lange-Asschenfeldt, Christian, Müller, M. J., Paulzen, M., Regen, Francesca, Steiger, Axel, Benkert, Otto, Anghelescu, Ion, Fehr, Christoph, Gründer, Gerhard, Heiser, Philip, Hiemke, Christoph, Lange-Asschenfeldt, Christian, Müller, M. J., Paulzen, M., Regen, Francesca, and Steiger, Axel

Published
2010
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31. Trimipramin

Author

Benkert, Otto, Anghelescu, Ion, Fehr, Christoph, Gründer, Gerhard, Heiser, Philip, Hiemke, Christoph, Lange-Asschenfeldt, Christian, Müller, M. J., Paulzen, M., Regen, Francesca, Steiger, Axel, Benkert, Otto, Anghelescu, Ion, Fehr, Christoph, Gründer, Gerhard, Heiser, Philip, Hiemke, Christoph, Lange-Asschenfeldt, Christian, Müller, M. J., Paulzen, M., Regen, Francesca, and Steiger, Axel

Published
2010
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32. Sildenafil

Author

Benkert, Otto, Anghelescu, Ion, Fehr, Christoph, Gründer, Gerhard, Heiser, Philip, Hiemke, Christoph, Lange-Asschenfeldt, Christian, Müller, M. J., Paulzen, M., Regen, Francesca, Steiger, Axel, Benkert, Otto, Anghelescu, Ion, Fehr, Christoph, Gründer, Gerhard, Heiser, Philip, Hiemke, Christoph, Lange-Asschenfeldt, Christian, Müller, M. J., Paulzen, M., Regen, Francesca, and Steiger, Axel

Published
2010
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33. Nikotin

Author

Benkert, Otto, Anghelescu, Ion, Fehr, Christoph, Gründer, Gerhard, Heiser, Philip, Hiemke, Christoph, Lange-Asschenfeldt, Christian, Müller, M. J., Paulzen, M., Regen, Francesca, Steiger, Axel, Benkert, Otto, Anghelescu, Ion, Fehr, Christoph, Gründer, Gerhard, Heiser, Philip, Hiemke, Christoph, Lange-Asschenfeldt, Christian, Müller, M. J., Paulzen, M., Regen, Francesca, and Steiger, Axel

Published
2010
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34. Aripiprazol

Author

Benkert, Otto, Anghelescu, Ion, Fehr, Christoph, Gründer, Gerhard, Heiser, Philip, Hiemke, Christoph, Lange-Asschenfeldt, Christian, Müller, M. J., Paulzen, M., Regen, Francesca, Steiger, Axel, Benkert, Otto, Anghelescu, Ion, Fehr, Christoph, Gründer, Gerhard, Heiser, Philip, Hiemke, Christoph, Lange-Asschenfeldt, Christian, Müller, M. J., Paulzen, M., Regen, Francesca, and Steiger, Axel

Published
2010
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37. Pocket Guide Psychopharmaka von A bis Z

Author

Benkert, Otto, primary, Anghelescu, I.-G., additional, Gründer, G., additional, Heiser, P., additional, Hiemke, C., additional, Himmerich, H., additional, Kiefer, F., additional, Lange-Asschenfeldt, C., additional, Müller, M.J., additional, Paulzen, M., additional, Regen, F., additional, Steiger, A., additional, and Weber, F., additional

Published
2017
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40. Therapeutic reference range for aripiprazole revised: A systematic review and combined analysis

Author

Hart, X.M., additional, Hiemke, C., additional, Clement, H.W., additional, Conca, A., additional, Eichentopf, L., additional, Faltraco, F., additional, Florio, V., additional, Grüner, J., additional, Havemann-Reinecke, U., additional, Lense, X., additional, Molden, E., additional, Paulzen, M., additional, Riemer, T.G., additional, Schoretsanitis, G., additional, and Gründer, G., additional

Published
2022
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41. Hypericum/Johanniskraut-Extrakte

Author

Benkert, Otto, Anghelescu, Ion, Fehr, Christoph, Gründer, Gerhard, Heiser, Philip, Hiemke, Christoph, Lange-Asschenfeldt, Christian, Müller, M. J., Paulzen, M., Regen, Francesca, Steiger, Axel, Benkert, Otto, Anghelescu, Ion, Fehr, Christoph, Gründer, Gerhard, Heiser, Philip, Hiemke, Christoph, Lange-Asschenfeldt, Christian, Müller, M. J., Paulzen, M., Regen, Francesca, and Steiger, Axel

Published
2010
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42. Galantamin

Author

Benkert, Otto, Anghelescu, Ion, Fehr, Christoph, Gründer, Gerhard, Heiser, Philip, Hiemke, Christoph, Lange-Asschenfeldt, Christian, Müller, M. J., Paulzen, M., Regen, Francesca, Steiger, Axel, Benkert, Otto, Anghelescu, Ion, Fehr, Christoph, Gründer, Gerhard, Heiser, Philip, Hiemke, Christoph, Lange-Asschenfeldt, Christian, Müller, M. J., Paulzen, M., Regen, Francesca, and Steiger, Axel

Published
2010
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43. Ginkgo biloba

Author

Benkert, Otto, Anghelescu, Ion, Fehr, Christoph, Gründer, Gerhard, Heiser, Philip, Hiemke, Christoph, Lange-Asschenfeldt, Christian, Müller, M. J., Paulzen, M., Regen, Francesca, Steiger, Axel, Benkert, Otto, Anghelescu, Ion, Fehr, Christoph, Gründer, Gerhard, Heiser, Philip, Hiemke, Christoph, Lange-Asschenfeldt, Christian, Müller, M. J., Paulzen, M., Regen, Francesca, and Steiger, Axel

Published
2010
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44. Escitalopram

Author

Benkert, Otto, Anghelescu, Ion, Fehr, Christoph, Gründer, Gerhard, Heiser, Philip, Hiemke, Christoph, Lange-Asschenfeldt, Christian, Müller, M. J., Paulzen, M., Regen, Francesca, Steiger, Axel, Benkert, Otto, Anghelescu, Ion, Fehr, Christoph, Gründer, Gerhard, Heiser, Philip, Hiemke, Christoph, Lange-Asschenfeldt, Christian, Müller, M. J., Paulzen, M., Regen, Francesca, and Steiger, Axel

Published
2010
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49. Yohimbin

Author

Benkert, Otto, Anghelescu, Ion, Fehr, Christoph, Gründer, Gerhard, Heiser, Philip, Hiemke, Christoph, Lange-Asschenfeldt, Christian, Müller, M. J., Paulzen, M., Regen, Francesca, Steiger, Axel, Benkert, Otto, Anghelescu, Ion, Fehr, Christoph, Gründer, Gerhard, Heiser, Philip, Hiemke, Christoph, Lange-Asschenfeldt, Christian, Müller, M. J., Paulzen, M., Regen, Francesca, and Steiger, Axel

Published
2010
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