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Dengue hemorrhagic fever is one infectious diseases that have high case fatality rate in Indonesia. The aim of this study was to descibe the antibody anti-dengue profile in dengue hemorrhagic fever patients at Dr. Soetomo Hospital Surabaya. This study was epidemiological descriptive study to aims prevalence primary and secondary infection of dengue hemorrhagic fever and its clinical appearances. This study used 85 samples by taking medical record data of IgM and IgG anti-dengue serologic test from Internal Medicine Department, Dr. Soetomo Hospital, Surabaya, between January to December 2010. The data were collected and analyzed in diagrams and tables. Result of this study showed 25 (29,4%) patients had positive IgM serologic test, 14 (16,4%) patients had positive IgG serologic test and 46 (54,2%) patients had positive IgM and IgG serologic test. In primary infections, the history of fever was 3.8±1.2 days; platelet counts 58,6±21,4/ml and bleeding sign 37% of 25 patients. In secondary infections, the history of fever was 4.28±1.15 days; platelet count was 44,17±24,2/ml and bleeding sign 52% of 60 patients. In conclusion, patients with secondary infection have higher prevalence than primary infection. Then in secondary infection had more severe clinical appearance than primary infection.

Hemophagocytic lymphohistiocytosis (HLH) is derived from the word hemophagocytosis, in which macrophages infiltrate tissues extensively and unspecifically phagocyte blood cells and bone marrow cells. HLH is rare, difficult to recognize and the mortality rate is high, especially in adults. Immediate diagnosis and therapy are essential. The introduction of HLH triggers is important as therapy is based on the underlying triggers. The patient in this study was a 72-year-old female presented with fever 1 week before admission. She had anemic conjunctiva and splenomegaly. Laboratory results were as follows: Hb: 9.2 g/dL, PLT: 73,000/µL, WBC: 3.400/µL, neutrophil: 0.6%, triglycerides: 284 mg/dL, ferritin: 7500 ng/mL. Bone marrow aspiration showed hypocellular marrow with increased angry macrophage. The patient received dexamethasone, Intravenous Immunoglobulins (IVIG), tranfusion of 1 bag of Packed Red Cell (PRC) and Thrombocyte Concentrate (TC). Patient showed symptoms as follows: fever (t=40oC), splenomegaly (abdominal ultrasound results), sitopenia (hb: 9.2 g/dL, % neutrophils: 0.6%, PLT: 73 x 103/µL), hypertriglyceridemia (284 mg/dL), hyperferritinemia (7500 ng/mL) and hemofagocytosis in the bone marrow. Based on the criteria of the updated HLH 2004, it was concluded that the patient was diagnosed with HLH. The total Hscore in this patient was 269, which is also eligible for enforcement of HLH diagnosis. In conclusion, diagnosis of HLH based on the existing scoring system should be one of the considerations in patients with cytoopenia with febris, especially when accompanied with a history of severe infection, malignancy, and previous use of immunosuppressants. [ABSTRACT FROM AUTHOR]

Author's Abstract, COPYRIGHT 1999, Mineralogical Society of America Khmaralite, Ca(sub 0.04)Mg(sub 5.46)Fe(super 3+)(sub 0.12)Fe(super 2+)(sub 1.87)Al(sub 14.26)Be(sub 1.43)B(sub 0.02)Si(sub 4.80)O(sub 40), is a new mineral cosely related to sapphirine from Khmara Bay, Enderby Land, Antarctica. It occurs in a pegmatite metamorphosed at T>820 degrees C, P>10kbar. The minerals surinamite, musgravite, and sillimanite associated with khmaralite at Casey Bay Saturate it in BeO, and thus its BeO content could be close to the maximum possible. Optically, khmaralite is biaxial (-); at lambda = 589 nm, alpha = 1.725(2), beta = 1.740(2), gamma = 1.741(2) 2V(sub meas) = 34.4 (1.8) degrees, v>r strong, and beta // b. The weak superstructure reported using electron diffraction has been confirmed by single-crystal X-ray diffraction. The superstructure corresponds to a doubling of the a axis in monoclinic sapphirine-2M (P2(sub 1)/c setting) with the following unit-cell parameters: a = 19.800(1), b = 14.371(1), c = 11.254(1) Angstroms, Beta = 125.53(1) degrees, Z = 4, D(sub calc) = 3.61 g/cm(super 3). Using a simplified chemical formula of Mg(sub 5.46)Al(sub 14.28)Fe(sub 2.00)Si(sub 4.80)Be(sub 1.46)O(sub 40), the fully anisotropic structure refinement of all site occupancies, including Al vs Mg and Al vs. Si on the 16 octahedral (M) and 12 tetrahedral (T) sites respectively, establishes that the 2Xa superstructure results primarily from ordering in the doubled (T1 > T6, T7 > T12) tetrahedral chain, which is parallel to the a axis. The strongest contribution comes from Al-Si-Be ordering on the T2 (33-16-51%) vs. T8 (0-95-5%) and T3 (4-78-18%) vs. T9 (30-0-70%) sites. Thus, the sequence Al-Si-Al in sapphirine is replaced by the sequence Si-Be-Si in khmaralite; i.e., Be replaces Si on two sites and Si replaces Al on on four adjacent sites, resulting in an indirect replacement of Al by Be by the coupled substitution Be + Si = 2Al. The Be distribution in khmaralite and the strong preference for Be/Al mixing over Be/Si mixing appear to satisfy the bonding requirements of the bridging O atoms by minimizing the number of Be-O-Be and Be-O-Al linkages.

The method of increments (MoI) has been employed using the complete active space formalism in order to calculate the dissociation curve of beryllium ring-shaped clusters Ben of different sizes. Benchmarks obtained through different quantum chemical methods including the ab initio density matrix renormalization group were used to verify the validity of the MoI truncation which showed a reliable behavior for the whole dissociation curve. Moreover we investigated the size dependence of the correlation energy at different interatomic distances in order to extrapolate the values for the periodic chain and to discuss the transition from a metal-like to an insulator-like behavior of the wave function through quantum chemical considerations. [ABSTRACT FROM AUTHOR]

Immune related pancytopenia (IRP) is a peripheral pancytopenia caused by bone marrow failure due to an autoimmune process. A 41 year old female presented with gum bleeding 4 days prior to admission. She had anemic conjunctiva and no organomegaly. Laboratory results were as follows Hb: 7.9 g/dL, WBC: 3,200/ìL, PLT: 6,000/ìL, IPF: 4.7% and RET: 0.44%. Bone marrow aspiration was dominated by clusters of erythroblastic islands and activated macrophages. Confirmatory examination with bone marrow mononuclear cells coombs test (BMMNC Coombs Test) showed positive results. The patient received dexamethasone and trasnfusions with both packed red cells (PRC) and platelet concentrate (PC) apheresis. Mechanism of pancytopenia in patients is an autoimmune process caused by an autoantibody towards hematopoeitic cells in the bone marrow. B lymphocytes over produces this autoantibody. Ig G autoantibody also activates macrophages that will phagocyte hematopoeitic cells, whereas the Ig M autoantibody activates the complement system that causes the lysis of hematopoietic cells. The diagnosis of IRP in this patient was based on peripheral pancytopenia with an increase of Erythroblastic Island clusters and activated macrophages in the bone marrow. The BMMNC Coombs Test confirmed the diagnosis. [ABSTRACT FROM AUTHOR]

In this contribution, we reinvestigate the interaction of nitric oxide with a gold(111) surface using plane-wave density functional theory, with particular emphasis on the role of intermode coupling. A new global representation of the potential energy surface is obtained from the ab initio data by non-linear adjustment, yielding a set of physically motivated parameters. The novel functional form improves on its parent [Marquardt et al. J. Chem. Phys. 132, 074108 (2010)] by addressing the variation of the charge transfer character of the electronic structure data, and by treating surface corrugation via translationally invariant weighting functions of lower-dimensional, high-symmetry sites. Contrary to previous studies, the adsorption minimum does not favour the hollow sites and is found at a strongly tilted orientation (circa 60) on top of a gold atom of the topmost layer. High-dimensional anharmonic vibrational analysis performed using a Lanczos-based contracted iterative procedure reveals that the low-lying excited vibrational states retain a strongly tilted orientation and remain predominantly localised at the atop site. These findings are expected to have important implications for the interpretation of recent NO scattering experiments. [ABSTRACT FROM AUTHOR]

The crystal structure of philolithite, [Pb.sub.12][O.sub.6]Mn[(Mg,Mn).sub.2][(Mn,Mg).sub.4] ([SO.sub.4])[([CO.sub.3]).sub.4][Cl.sub.4][(OH).sub.12], [P4.sub.2]/nnm, a = 12.627(9), c = 12.595(9) [Angstrom], V = 2008(2) [[Angstrom].sup.3], Z = 2 has been solved by Patterson difference-Fourier syntheses and refined to R = 0.053 for 814 [F.sub.o] [is greater than] 4[Sigma].sub.Fo] using MoK[Alpha] X-ray data. In the structure, Mn[O.sub.6] octahedra form straight chains parallel to [110] and [1 bar] 10] by sharing opposite octahedral edges. Octahedra within the chains are further linked by sharing free corners with Mn[O.sub.4] and [SO.sub.4] tetrahedra and [CO.sub.3] triangles. The Mn[O.sub.4] and [SO.sub.4] tetrahedra also form bridging struts between octahedral chains, connecting them in the [001] direction into an open framework. The Pb, C1, and non-framework O atoms occupy the open spaces within the framework. The 10- and 12-fold coordinations of the Pb atoms exhibit the lone-pair effect. Pb atoms link via short bonds to non-framework O atoms to form chains parallel to [110] and [[bar] 1 10]. When viewed down [111], [[bar] 11 1], [1 [bar] 11], or [[bar] 1 1 [bar] 1], the framework (less the [CO.sub.3] groups) is seen to be based upon cubic closest-packing of anions. This open framework of composition [MATHEMATICAL EXPRESSION NOT REPRODUCIBLE IN ASCII], referred to as a closest-packed trellis, is the fundamental unit for the structure.