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5 results on '"Paulo Hilário N. Saldiva"'

1. Análise do monitoramento da qualidade do ar no Brasil

Author

Evangelina da Motta P. A. de Araújo Vormittag, Samirys Sara Rodrigues Cirqueira, Hélio Wicher Neto, and Paulo Hilário N. Saldiva

Subjects
Qualidade do ar, Poluição do ar, Monitoramento, Meio Ambiente, Brasil, Social sciences (General), H1-99
Abstract

RESUMO Este artigo descreve as condições atuais da rede de monitoramento de qualidade do ar no Brasil. Os resultados revelam que apenas dez estados e o DF realizam o monitoramento através de 371 estações ativas - 80% delas na Região Sudeste. Outras informações relevantes são: (i) 41,2% das estações nacionais são privadas; no estado do Rio de Janeiro elas representam 60% do total de suas estações, enquanto no estado de São Paulo, 100% das estações são públicas; (ii) o MP10 é o poluente mais monitorado em 62,8% das estações e o MP2,5 em apenas 25,9% delas; e, (iii) a comunicação dos dados de monitoramento em tempo real à população ocorre em cinco estados. Após trinta anos de sua criação, a Rede Nacional de Qualidade do Ar encontra-se incompleta, e insuficientemente implantada, inviabilizando uma adequada gestão da qualidade do ar pelos órgãos ambientais.

Published
2021
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2. Rapid Mortality Surveillance of COVID-19 Using Verbal Autopsy

Author

Amaro N. Duarte-Neto, Maria de Fátima Marinho, Lucia P. Barroso, Carmen D. Saldiva de André, Luiz Fernando F. da Silva, Marisa Dolhnikoff, Paulo Afonso de André, Catia M. Minto, Catia S. de Moura, Thábata F. Leite, Jair Theodoro Filho, Renata Aparecida de Almeida Monteiro, Philip Setel, Martin W. Bratschi, Robert Mswia, Paulo Hilário N. Saldiva, and Ana Luiza Bierrenbach

Subjects
mortality, surveillance, COVID-like illness, minimally invasive autopsy, InterVA CRMS, Public aspects of medicine, RA1-1270
Published
2021
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3. List of Contributors

Author

Gulfam Ahmad, Manaf Alom, Saad Alshahrani, Laith Alzweri, Anthony Atala, Mira Aubuchon, Ahmet Ayaz, Fouad M. Badr, Tolulope O. Bakare, Alma R. Bartolome, Rudrarup Bhattacharjee, Colin Bishop, Trinity Bivalacqua, Arthur L. Burnett, Sarah Collica, Carlos T. Da Ros, Rima Dada, Kenneth DeLay, Linley Diao, Fotios Dimitriadis, Erma Z. Drobnis, Ola El-Habit, Donald P. Evenson, Andrew T. Gabrielson, Fady Ghali, Milton Ghirelli-Filho, Sidney Glina, Túlio M. Graziottin, Narmada P. Gupta, Serap Gur, Jorge Hallak, Nora M. Haney, Brooke A. Harnisch, Daniel J. Heidenberg, Wayne J.G. Hellstrom, Ralf Henkel, Antonio Hernandez, Stanton C. Honig, Yuji Hotta, Chris Kannady, Kazunori Kimura, Narasimhan Kothandaraman, Jason R. Kovac, Shiv B. Kumar, Joseph A. La Nasa, Michael Lao, James Liu, Kara E. McAbee, Chandra Mohan, Malhar J. Parikh, Filippo Pederzoli, Samuel S. Pendergraft, Angela Pressman, Omer A. Raheem, Mahadevan R. Rajasekaran, Amit Reddy, Ibraheem Rehman, Bashir M. Rezk, Shubhadeep Roychoudhury, Hooman Sadri-Ardekani, Paulo Hilário N. Saldiva, Suresh C. Sikka, Sotirios Skouros, Nikolaos Sofikitis, Atsushi Takenaka, Madhuri Tolahunase, Abdulmaged M. Traish, Landon Trost, Hoang M. Tue Nguyen, Mariana M. Veras, Run Wang, and Kevin Wymer

Published
2018
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4. Inflammation and remodeling in infantile, juvenile, and adult allergic sensitized mice

Author

Denise S, Carnieli, Eliane, Yoshioka, Luiz Fernando F, Silva, Tatiana, Lanças, Fernanda M, Arantes, Adenir, Perini, Milton A, Martins, Paulo Hilário N, Saldiva, Marisa, Dolhnikoff, and Thais, Mauad

Subjects
Aging, Mice, Inbred BALB C, Hyperplasia, Ovalbumin, T-Lymphocytes, Passive Cutaneous Anaphylaxis, Cell Count, Muscle, Smooth, Immunoglobulin E, Immunohistochemistry, Eosinophils, Plethysmography, Disease Models, Animal, Mice, Animals, Newborn, Respiratory Hypersensitivity, Airway Remodeling, Animals, Female, Goblet Cells, Injections, Intraperitoneal
Abstract

Airway structural changes occur early in childhood asthma, but it is unknown whether the development of airway alterations in children is similar to that of adults. We compared inflammation and remodeling parameters in allergic sensitized infantile, juvenile, and adult mice.Infantile mice (18D) were sensitized with three intraperitoneal injections (i.p.) of ovalbumin (OVA) at days 5 and 7 and challenged with OVA at days 14-16. The 18D1 group received an additional challenge at days 9-11. The juvenile mice (40D) received challenges at days 22-24 and 36-38. Adult mice (100D) were sensitized at days 60-62 and received three inhalations at days 77-79 and 96-98. Animals were submitted to whole body plethysmography. Airway eosinophils, CD3+ T-lymphocytes, IL-5+ cells, mucus content, collagen and reticular fibers density, and smooth muscle thickness were quantified.All sensitized animals presented with airway hyperresponsiveness, without differences in eosinophil cell density. The density of CD3+ T-cells was higher in the 100D and 18D1 groups than in the 18D and 40D groups. Infantile sensitized groups demonstrated increased interleukin-5 expression in the airways. Infantile mice demonstrated more mucus in the bronchiolar epithelium than the 40D and 100D mice. The 18D animals demonstrated less collagen than the 18D1 group. Juvenile and adult mice had increased airway smooth muscle thickness when compared to age-matched controls, but no differences were observed in the infantile groups.We have shown that infantile mice develop inflammatory and structural alterations in the airways that are partially different from those developed in older animals.

Published
2010

5. Clinicopathological correlates of Alzheimer's disease in a general autopsy series from Brazil

Author

Lea Tenenholz Grinberg, Renata Eloah de Lucena Ferretti, Renata E.P. Leite, Jose Marcelo Farfel, Silmara P. Pacheco, Ana Teresa Di Lorenzo Alho, Renata P. Grisoli, Heidy T.M. Matos, Eliza G. Moreira, Erika S. Balbino, Katia C. Oliveira, Sergio Rosemberg, Heráclito Barbosa Carvalho, Carlos Augusto G. Pasquallucci, Paulo Hilario N. Saldiva, Wilson Jacob-Filho, and Ricardo Nitrini

Subjects
Alzheimer's disease, dementia, diagnostic criteria, neuropathological criteria, brain bank, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Abstract The current neuropathological staging models of Alzheimer's disease (AD) have been developed within the last 20 years. Nevertheless, they were mostly tested on Caucasians of Northern European ancestry or on Asians. Objective: To verify which of the accepted neuropathologic criteria best discriminates AD from normal aging in a well characterized Brazilian clinicopathological series. Methods: A random sample consisting of 89 subjects belonging to the Brazilian Brain Bank of the Aging Brain Study were clinically and neuropathologically fully assessed using immunohistochemistry. Clinical and functional statuses were assessed by interviewing a reliable informant. The Clinical dementia rating scale (CDR) was compared to Braak and Braak stage, the consortium to establish a registry for Alzheimer's disease (CERAD) score and NIA-Reagan (National Institute of Aging - Reagan Institute) score. Subjects with a neuropathologic diagnosis other then AD were excluded (n=27). Results: The CDR score distribution for the 62 selected subjects was as follows: CDR0=39, CDR0.5=9, CDR³1=14. There were no differences regarding age, gender and education among the groups. CDR score correlated best with the CERAD score (r=0.5303; p

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