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12 results on '"Pauli, Jordan L."'

8. Transient Receptor Potential Ankyrin 1 Mediates Hypoxic Responses in Mice

Author

Chen, Sichong, primary, Takahashi, Nobuaki, additional, Chen, Changping, additional, Pauli, Jordan L., additional, Kuroki, Chiharu, additional, Kaminosono, Jun, additional, Kashiwadani, Hideki, additional, Kanmura, Yuichi, additional, Mori, Yasuo, additional, Ou, Shaowu, additional, Hao, Liying, additional, and Kuwaki, Tomoyuki, additional

Published
2020
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9. Parabrachial Calcaneurons drive nociplasticity

Author

Condon, Logan F., Yu, Ying, Park, Sekun, Cao, Feng, Pauli, Jordan L., Nelson, Tyler S., and Palmiter, Richard D.

Abstract

Pain that persists beyond the time required for tissue healing and pain that arises in the absence of tissue injury, collectively referred to as nociplastic pain, are poorly understood phenomena mediated by plasticity within the central nervous system. The parabrachial nucleus (PBN) is a hub that relays aversive sensory information and appears to play a role in nociplasticity. Here, by preventing PBN Calcaneurons from releasing neurotransmitters, we demonstrate that activation of Calcaneurons is necessary for the manifestation and maintenance of chronic pain. Additionally, by directly stimulating Calcaneurons, we demonstrate that Calcaneuron activity is sufficient to drive nociplasticity. Aversive stimuli of multiple sensory modalities, such as exposure to nitroglycerin, cisplatin, or lithium chloride, can drive nociplasticity in a Calca-neuron-dependent manner. Aversive events drive nociplasticity in Calcaneurons in the form of increased activity and excitability; however, neuroplasticity also appears to occur in downstream circuitry.

Published
2024
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11. Direct excitation of parvalbumin-positive interneurons by M1muscarinic acetylcholine receptors: roles in cellular excitability, inhibitory transmission and cognition

Author

Yi, Feng, primary, Ball, Jackson, additional, Stoll, Kurt E., additional, Satpute, Vaishali C., additional, Mitchell, Samantha M., additional, Pauli, Jordan L., additional, Holloway, Benjamin B., additional, Johnston, April D., additional, Nathanson, Neil M., additional, Deisseroth, Karl, additional, Gerber, David J., additional, Tonegawa, Susumu, additional, and Lawrence, J. Josh, additional

Published
2014
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12. Parabrachial Calca neurons drive nociplasticity.

Author

Condon LF, Yu Y, Park S, Cao F, Pauli JL, Nelson TS, and Palmiter RD

Abstract

Pain that persists beyond the time required for tissue healing and pain that arises in the absence of tissue injury are poorly understood phenomena mediated by plasticity within the central nervous system. The parabrachial nucleus (PBN) is a hub that relays aversive sensory information and appears to play a role in nociplasticity. Here, by preventing PBN Calca neurons from releasing neurotransmitter or directly stimulating them we demonstrate that activation of Calca neurons is both necessary for the manifestation of chronic pain after nerve ligation and is sufficient to drive nociplasticity in wild-type mice. Aversive stimuli such as exposure to nitroglycerin, cisplatin, or LiCl can drive nociplasticity in a Calca -neuron-dependent manner. Calcium fluorescence imaging reveals that nitroglycerin activates PBN Calca neurons and potentiates their responses to mechanical stimulation. The activity and excitability of Calca neurons increased for several days after aversive events, but prolonged nociplasticity likely occurs in downstream circuitry., Competing Interests: DECLARARTION OF INTERSTS Authors declare no conflicting interests.

Published
2023
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