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3 results on '"Paula de Cassia Soares"'

1. Head and Neck Non-Melanoma Skin Cancer Treated By Superficial X-Ray Therapy: An Analysis of 1021 Cases.

Author

Daniel Grossi Marconi, Bruno da Costa Resende, Erick Rauber, Paula de Cassia Soares, Jose Maria Fernandes, Niraj Mehta, Andre Lopes Carvalho, Patrick A Kupelian, and Allen Chen

Subjects
Medicine, Science
Abstract

To report a single-institutional experience with the use of Superficial X-Ray Therapy (SXRT) for head and neck non-melanoma skin cancer (N-MSC) and to compare outcomes by prescribed fractionation schedules.The medical records of 597 patients with 1021 lesions (720 BCC, 242 SCC, 59 SCC in situ) treated with kilovoltage radiation from 1979-2013 were retrospectively reviewed. The majority of patients were treated according to 1 of 3 institutional protocols based on the discretion of the radiation oncologist: 1) 22 x 2.5 Gy; 2) 20 x 2.5 Gy; 3) 30 x 2.0 Gy. "T" stage at first presentation was as follows: Tis (59); T1 (765); T2 (175); T3 (6), T4 (9); Tx, (7). All patients were clinical N0 and M0 at presentation. Chi-square test was used to evaluate any potential association between variables. The Kaplan-Meier method was used to analyze survival with the Log Rank test used for comparison. A Cox Regression analysis was performed for multivariate analysis.The median follow up was 44 months. No significant difference was observed among the 3 prescribed fractionation schemes (p = 0.78) in terms of RTOG toxicity. There were no failures among SCC in situ, 37 local failures (23 BCC, 14 SCC), 5 regional failures (all SCC) and 2 distant failures (both SCC). For BCC, the 5-year LC was 96% and the 10-year LC was 94%. For SCC the corresponding rates of local control were 92% and 87%, respectively (p = 0.03). The use of >2.0 Gy daily was significantly associated with improved LC on multivariate analysis (HR: 0.17; CI 95%: 0.05-0.59).SXRT for N-MSC of the head and neck is well tolerated, achieves excellent local control, and should continue to be recommended in the management of this disease. Fractionation schedules using >2.0 Gy daily appear to be associated with improved LC.

Published
2016
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2. Head and Neck Non-Melanoma Skin Cancer Treated By Superficial X-Ray Therapy: An Analysis of 1021 Cases

Author

André Lopes Carvalho, Erick Rauber, Niraj Mehta, Allen M. Chen, Paula de Cassia Soares, Bruno da Costa Resende, Daniel Grossi Marconi, Patrick A. Kupelian, Junior Jose Maria Fernandes, and Li, Jian Jian

Subjects
Male, Skin Neoplasms, medicine.medical_treatment, Cancer Treatment, lcsh:Medicine, X-Ray Therapy, Pathology and Laboratory Medicine, 030207 dermatology & venereal diseases, 0302 clinical medicine, Medicine and Health Sciences, Superficial X-ray therapy, Fractionation, Treatment Failure, lcsh:Science, Head and neck, Dose Fractionation, Cancer, Multidisciplinary, Radiation, Middle Aged, Separation Processes, Oncology, Head and Neck Neoplasms, 030220 oncology & carcinogenesis, Female, Radiology, Anatomy, Research Article, Adult, medicine.medical_specialty, Histology, General Science & Technology, Surgical and Invasive Medical Procedures, Research and Analysis Methods, 03 medical and health sciences, Signs and Symptoms, Diagnostic Medicine, Clinical Research, medicine, Humans, Retrospective Studies, Aged, business.industry, lcsh:R, Dose fractionation, Biology and Life Sciences, Retrospective cohort study, medicine.disease, Surgery, Radiation therapy, Face, Lesions, lcsh:Q, Dose Fractionation, Radiation, Skin cancer, business, Head, Neck, Non melanoma
Abstract

Introduction To report a single-institutional experience with the use of Superficial X-Ray Therapy (SXRT) for head and neck non-melanoma skin cancer (N-MSC) and to compare outcomes by prescribed fractionation schedules. Materials and Methods The medical records of 597 patients with 1021 lesions (720 BCC, 242 SCC, 59 SCC in situ) treated with kilovoltage radiation from 1979–2013 were retrospectively reviewed. The majority of patients were treated according to 1 of 3 institutional protocols based on the discretion of the radiation oncologist: 1) 22 x 2.5 Gy; 2) 20 x 2.5 Gy; 3) 30 x 2.0 Gy. "T" stage at first presentation was as follows: Tis (59); T1 (765); T2 (175); T3 (6), T4 (9); Tx, (7). All patients were clinical N0 and M0 at presentation. Chi-square test was used to evaluate any potential association between variables. The Kaplan-Meier method was used to analyze survival with the Log Rank test used for comparison. A Cox Regression analysis was performed for multivariate analysis. Results The median follow up was 44 months. No significant difference was observed among the 3 prescribed fractionation schemes (p = 0.78) in terms of RTOG toxicity. There were no failures among SCC in situ, 37 local failures (23 BCC, 14 SCC), 5 regional failures (all SCC) and 2 distant failures (both SCC). For BCC, the 5-year LC was 96% and the 10-year LC was 94%. For SCC the corresponding rates of local control were 92% and 87%, respectively (p = 0.03). The use of >2.0 Gy daily was significantly associated with improved LC on multivariate analysis (HR: 0.17; CI 95%: 0.05–0.59). Conclusion SXRT for N-MSC of the head and neck is well tolerated, achieves excellent local control, and should continue to be recommended in the management of this disease. Fractionation schedules using >2.0 Gy daily appear to be associated with improved LC.

Published
2016

3. MRI and DWI: the future in cervical cancer?

Author

Daniel Grossi Marconi, Erick Rauber, and Paula de Cassia Soares

Subjects
Cervical cancer, Diffusion, business.industry, lcsh:R, medicine, Cancer, lcsh:Medicine, Nuclear medicine, business, medicine.disease, MRI
Abstract

This article is an editorial, and it doesn't include an abstract. Full text of this article is available in HTML and PDF.Cite this article as:Marconi D, Rauber E, Soares P. MRI and DWI: the future in cervical cancer? Int J Cancer Ther Oncol 2013;1(1):01018.DOI: 10.14319/ijcto.0101.8

Published
2013

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