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Objectives To investigate factors associated with severe COVID-19 in people with idiopathic inflammatory myopathy (IIM).Methods Demographic data, clinical characteristics and COVID-19 outcome severity of adults with IIM were obtained from the COVID-19 Global Rheumatology Alliance physician-reported registry. A 3-point ordinal COVID-19 severity scale was defined: (1) no hospitalisation, (2) hospitalisation (and no death) and (3) death. ORs were estimated using multivariable ordinal logistic regression. Sensitivity analyses were performed using a 4-point ordinal scale: (1) no hospitalisation, (2) hospitalisation with no oxygen (and no death), (3) hospitalisation with oxygen/ventilation (and no death) and 4) death.Results Of 348 patients, 48% were not hospitalised, 39% were hospitalised (and did not die) and 13% died. Older age (OR=1.59/decade, 95% CI 1.31 to 1.91), high disease activity (OR=3.50, 95% CI 1.25 to 9.83; vs remission), ≥2 comorbidities (OR=2.63, 95% CI 1.39 to 4.98; vs none), prednisolone-equivalent dose >7.5 mg/day (OR=2.40, 95% CI 1.09 to 5.28; vs no intake) and exposure to rituximab (OR=2.71, 95% CI 1.28 to 5.72; vs conventional synthetic disease-modifying antirheumatic drugs only) were independently associated with severe COVID-19. In addition to these variables, in the sensitivity analyses, male sex (OR range: 1.65–1.83; vs female) was also significantly associated with severe outcomes, while COVID-19 diagnosis after 1 October 2020 (OR range: 0.51–0.59; vs on/before 15 June 2020) was significantly associated with less severe outcomes, but these associations were not significant in the main model (OR=1.57, 95% CI 0.95 to 2.59; and OR=0.61, 95% CI 0.37 to 1.00; respectively).Conclusions This is the first large registry data on outcomes of COVID-19 in people with IIM. Older age, male sex, higher comorbidity burden, high disease activity, prednisolone-equivalent dose >7.5 mg/day and rituximab exposure were associated with severe COVID-19. These findings will enable risk stratification and inform management decisions for patients with IIM.

Abstract Background The idiopathic inflammatory myopathies (IIM, myositis) are a heterogeneous group of chronic autoimmune disorders causing considerable physical and mental health impact. There is a lack of formalised guidance defining best practice for the management of myositis, contributing to inconsistent care provision and some patients feeling isolated and unsupported. To address these issues, we evaluated the clinical services available to adults with myositis in the UK. We then created patient-centred standards of care using a structured process involving patients, their relatives and caregivers, physicians and allied healthcare professionals. Methods After an initial focus group, the clinical services available to patients with myositis were evaluated using a patient-completed questionnaire. Draft standards of care were created, each addressing deficits in care provision identified by patients. In response to feedback, including a two-stage modified Delphi exercise, these draft standards were iteratively improved until consensus was reached. Accompanying plain language versions of the standards of care and an audit tool were also created. Results We identified issues regarding diagnostic pathways, access to specialist services, advice and support regarding employment, medication-related adverse events and the treatment of extra-muscular manifestations. Fifteen standards of care were drafted. After modification, agreement was reached on eleven final standards of care. Conclusion These patient-centred standards of care for adults with myositis provide a benchmark for the evaluation of local practice. Their implementation will promote consistent good practice across care providers and empower patients when seeking access to local services.

ABSTRACT Introduction: CrossFit® is a physical training method that aims to promote physical fitness through the development of components such as aerobic capacity, strength and muscular endurance. Data regarding bruxism behaviors in CrossFit® practitioners are scarce, but previous studies have shown increased dental clenching behavior during weightlifting practices. Objective: The present study aimed to evaluate clinical signs of bruxism in CrossFit® practitioners. Methods: The sample comprised a convenience sample of CrossFit® practitioners (n=57), of both genders, aged 19-58 years. Outcome variables were as follows: Oral Behavior Checklist, the International Physical Activity Questionnaire and the Standardized Tool for the Assessment of Bruxism. Data were expressed in terms of absolute values and percentages. Spearman’s correlation and Fisher exact tests were used for statistical analysis, and a significance level of 5% was considered. Results: The mean age was 32.82 years, with a female majority (63.15%). CrossFit® practitioners frequently reported clenching their teeth during training practice (61.40%) and presented linea alba (82.45%), lip impression (54.38%), tongue impression (26.31%), bone exostosis (19.29%), tooth wear (61.40%) and non-carious cervical lesions (35.09%). Conclusions: No correlation was found between clinical signs of bruxism, oral behaviors and physical activity intensity; however, the results suggest that individuals who practice CrossFit® training have oral behaviors that can cause morpho-functional changes in the stomatognathic system, especially the habit of clenching their teeth during training. In addition, data emphasize the need for dental health education among CrossFit® practitioners, and more studies with a representative sample are necessary.

OBJETIVO: avaliar a prevalência de doença hepática gordurosa não alcoólica (DHGNA) em pacientes pediátricos com excesso de peso; verificar se parâmetros clínicos, antropométricos e laboratoriais diferem entre os pacientes com e sem DHGNA e associar as alterações com a presença de DHGNA. MÉTODOS: estudo retrospectivo observacional entre 2012-2017, envolvendo crianças e adolescentes do ambulatório de obesidade infantil, constituído por 2 grupos: COM-DHGNA e SEM-DHGNA. Considerou-se DHGNA a presença de esteatose hepática à ultrassonografia. VARIÁVEIS ESTUDADAS: idade, sexo, pressão arterial sistólica (PAS) e diastólica (PAD), peso de nascimento (PN), peso, altura, índice de massa corpórea (IMC), escore Z do IMC, circunferência abdominal (CA), glicemia de jejum, insulina, IR-HOMA, triglicerídeos, colesterol total e frações, transaminases (ALT e AST) e hormônio estimulador da tireoide (TSH). Análise estatística por teste de Qui-quadrado e Mann-Whitney para comparação entre os dois grupos; análise de regressão logística multivariada para associação com DHGNA; ppercentil 95 (29 vs 14; p=0,003), IMC (29,7 vs 27,5; p=0,010), escore Z do IMC (3,2 vs 2,9; p=0,036), CA (93 vs 88,5; p=0,046), insulina (15,7 vs 12,8; p=0,028), IR-HOMA (3,2 vs 2,5; p=0,028) e ALT (39 vs 27, p

RESUMO Objetivo Descrever o perfil epidemiológico e analisar a tendência temporal da mortalidade por suicídio entre adolescentes (10-19 anos) do Nordeste brasileiro, no período de 2001 a 2015. Métodos Trata-se de estudo observacional, que teve como cenário a região Nordeste do Brasil. O período de estudo foi de 2001 a 2015. Consideraram-se as mortes por lesão autoprovocada intencionalmente (X60 a X84), intoxicação exógena de intenção indeterminada (Y10 a Y19) e sequela de lesões autoprovocadas intencionalmente (Y87.0), de acordo com a 10ª Revisão da Classificação Internacional de Doenças (CID-10), de adolescentes de 10 a 19 anos. As variáveis analisadas foram: sexo, faixa etária, raça/cor, CID específico, estado de residência e taxa de mortalidade por suicídio/100.000 habitantes. Resultados Foram registrados 3.194 óbitos em decorrência de suicídio na faixa etária estudada, com predomínio do sexo masculino (62,1%; n = 1.984), faixa etária de 15 a 19 anos (84,8%; n = 2.707), raça/cor parda (65,4%; n = 2.090); entre quatro e sete anos de escolaridade (31,7%; n = 1.011) e no CID X70 (47,8%; n = 1.528). A tendência temporal de mortalidade foi crescente de 2001 a 2015 (APC: 2,4%; p < 0,01), com maiores taxas no sexo masculino. Observou-se tendência crescente da taxa de suicídios, no sexo masculino, em todo o período (AAPC: 2,9%; p < 0,01). No sexo feminino, identificou-se tendência decrescente a partir de 2004 (APC: -2,2%; p < 0,01). Conclusão O perfil epidemiológico foi caracterizado pelo sexo masculino, faixa etária de 15-19 anos, cor/raça parda e escolaridade média. A tendência apresentou padrão de crescimento no sexo masculino e declínio no feminino. Recomenda-se que políticas públicas sejam voltadas para a população adolescente.

As manifestações patológicas em edificações configuram-se como a falha no desempenho de uma estrutura quanto a sua estética, estabilidade e duração. O presente trabalho tem por objetivo identificar as principais manifestações patológicas presentes nas edificações da Universidade Federal de Roraima - UFRR, e os fatores que motivaram o surgimento de tais manifestações. Classificou-se as manifestações patológicas a partir de levantamento fotográfico, dados fornecidos pela Pró-Reitoria de Infraestrutura da UFRR; e de informações obtidas na literatura especializada. O estudo foi realizado no campus Paricarana da UFRR, localizado no município de Boa Vista, Roraima.