116 results on '"Paula Goolkasian"'
Search Results
2. BRIDGES: Real World Data, Assignments and Visualizations to Engage and Motivate CS Majors
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David Burlinson, Matthew Mcquaigue, Alec Goncharow, Kalpathi Subramanian, Erik Saule, Jamie Payton, and Paula Goolkasian
- Abstract
BRIDGES is a software framework for creating engaging assignments for required courses such as data structures and algorithms. It provides students with a simplified API that populates their own data structure implementations with live and real-world data, and provides the ability for students to easily visualize the data structures they create as part of routine classroom exercises. The objective is to use the infrastructure to promote a better understanding of the data structure and its underlying algorithms. This report describes the BRIDGES infrastructure and provides evaluation data collected over the first five years of the project. In the first 2 years, as we were developing the BRIDGES projects, our focus was on gathering data to assess whether the addition of the BRIDGES exercises had an effect on student retention of core concepts in data structures; and throughout the 5-year duration of the project, student interest and faculty feedback were collected online and anonymously. A mixed method design was used to evaluate the project impact. A quasiexperimental design compared student cohorts who were enrolled in comparable course sections that used BRIDGES with those that did not. Qualitative and quantitative measures were developed and used together with course grades and grade point averages. Interest and relevance in BRIDGES programming assignments was assessed with additional survey data from students and instructors. Results showed that students involved in BRIDGES projects demonstrated larger gains in knowledge of data structures compared to students enrolled in comparable course sections, as well as long-term benefits in their performance in four follow-on required courses. Survey responses indicated that some investment of time was needed to use BRIDGES, but the extra efforts were associated with several notable outcomes. Students and instructors had positive perceptions of the value of engaging in BRIDGES projects. BRIDGES can become a tool to get students more engaged in critical foundational courses, demonstrating relevance and context to today's computational challenges.
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- 2024
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3. Video Games and Stress: How Stress Appraisals and Game Content Affect Cardiovascular and Emotion Outcomes
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Anne Marie Porter and Paula Goolkasian
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stress ,stress appraisal ,cardiovascular – methods ,video games ,heart rate variabiity ,blood pressure ,Psychology ,BF1-990 - Abstract
Although previous studies have found that video games induce stress, studies have not typically measured all salient indicators of stress responses including stress appraisals, cardiovascular indicators, and emotion outcomes. The current study used the Biopsychosocial Model of Challenge and Threat (Blascovich and Tomaka, 1996) to determine if video games induce a cardiovascular stress response by comparing the effects of threat and challenge appraisals across two types of video games that have shown different cardiovascular outcomes. Participants received challenge or threat appraisal instructions, and played a fighting game (Mortal Kombat) or a puzzle game (Tetris). Study outcomes were heart rate variability, systolic and diastolic blood pressure, and positive and negative emotion ratings measured before, during and after gameplay. Results indicated that threat appraisal instructions increased negative emotion ratings and decreased heart rate variability, but not blood pressure, which is an essential marker for cardiovascular stress responses. Increased blood pressure and decreased heart rate variability was associated with fighting game players when compared with the puzzle game players, indicating a cardiovascular stress response; however, fighting game players also reported higher positive emotion ratings. Based on the study findings, video games do not induce stress responses like mental stressors used in previous research, demonstrating that the interactive player experience in video gaming may have more complex effects on stress outcomes. Future research should comprehensively measure biopsychosocial stress indicators and multiple emotional states over time to fully examine the relationship between video games and stress.
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- 2019
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4. Low Vitamin D States Observed in U.S. Marines and Navy Sailors with Early Multi-Symptom Illness
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Sean R. Maloney and Paula Goolkasian
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immune modulation ,vitamin D deficiency ,multi-symptom illness ,Epstein-Barr virus ,sensory neuritis ,deployment history ,Microbiology ,QR1-502 - Abstract
Research has implicated immune system inflammation as an underlying etiology of multi-symptom illnesses, and vitamin D has been shown to have a significant role in immune system function. In this retrospective review performed on the medical charts of service members who presented with signs and symptoms of multi-symptom illnesses, we focused on serum 25(OH)D3 levels and looked for associations of vitamin D status (deficient, insufficient, and normal) with age (20–31 years versus 31–56 years) and deployment status (war zones versus other). Two groups (U.S. Marines and Navy Sailors) were sampled and both showed high incidences of below normal vitamin D levels. However, with the Marines, age-related differences in serum levels (p = 0.009) were found only among those who deployed to Iraq/Afghanistan in comparison to those in non-combat locations. The comparison within the Navy sample showed that mobilized sailors had lower 25(OH)D3 levels than the group that did not deploy (p = 0.04). In addition, 100% of the sailors who deployed had below normal levels versus only 33% in the cadre group. The data suggest that personnel returning from a war zone with signs of early multi-symptom illness should be checked for low vitamin D status.
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- 2020
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5. Vitamin D levels and monospot tests in military personnel with acute pharyngitis: a retrospective chart review.
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Sean R Maloney, David Almarines, and Paula Goolkasian
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Medicine ,Science - Abstract
Some recent studies have proposed an important role for vitamin D in reducing the risk of infection by assisting in the suppression of viruses and by controlling the inflammatory response. A low vitamin D state may have a detrimental effect on the immune system's ability to produce activated CD8+ T cells, and it may increase the inflammatory reaction to Epstein Barr virus. The aim of this chart review was to see if serum 25 OH vitamin D3 levels in service members with acute pharyngitis were lower in those who had positive rather than negative monospot tests. A retrospective chart review was conducted on the medical records of service members who presented to sick call at Camp Lejeune, NC with acute pharyngitis from October 8, 2010 until June 30, 2011. Serum 25 OH vitamin D3 levels were compared between those with positive and negative monospot test results. Of the 25 records that were reviewed, there were 9 (36%) service members with positive results, and they were found to have lower vitamin D levels (Median = 20.80 ng/ml, Interquartile range = 10.15) than those with negative test results (Median = 30.35 ng/ml, Interquartile range = 17.05), Mann-Whitney U = 41, p = .039. Only 1 of the 9 with positive test results had a normal serum 25 OH vitamin D3 level (30 ng/ml or greater) compared with 9 of the 16 with negative test results. Optimal vitamin D stores may play a significant role in reducing the risk of developing acute mononucleosis but larger, prospective studies will be needed to verify these findings.
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- 2014
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6. Mapping Materials to Curriculum Standards for Design, Alignment, Audit, and Search.
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Alec Goncharow, Matthew Mcquaigue, Erik Saule, Kalpathi R. Subramanian, Jamie Payton, and Paula Goolkasian
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- 2021
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7. BRIDGES: A System to Enable Creation of Engaging Data Structures Assignments with Real-World Data and Visualizations.
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David Burlinson, Mihai Mehedint, Chris Grafer, Kalpathi R. Subramanian, Jamie Payton, Paula Goolkasian, Michael Youngblood, and Robert Kosara
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- 2016
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8. CS-Materials: A system for classifying and analyzing pedagogical materials to improve adoption of parallel and distributed computing topics in early CS courses
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Kalpathi Subramanian, Alec Goncharow, Erik Saule, Jamie Payton, Matthew Mcquaigue, and Paula Goolkasian
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Class (computer programming) ,Artificial Intelligence ,Computer Networks and Communications ,Hardware and Architecture ,Computer science ,Distributed computing ,ComputingMilieux_COMPUTERSANDEDUCATION ,Computer science curriculum ,Lack of knowledge ,Inclusion (education) ,Curriculum ,Software ,Theoretical Computer Science - Abstract
The NSF/IEEE-TCPP Parallel and Distributed Computing curriculum guidelines released in 2012 (PDC12) represents an effort to bring more parallel computing concepts into early computer science courses. To date, it has been moderately successful, with the inclusion of some PDC topics in the ACM/IEEE Computer Science curriculum guidelines in 2013 (CS13) and mentions of PDC topics in the Computing Curricula 2020. Additionally, some universities in the U.S. and around the world have started to cover some of these topics in early CS courses. Lack of knowledge of or training in PDC topics among instructors, along with the need to align early CS course content with prescribed learning objectives in the curricula, are often cited as hurdles for adoption in early CS courses. There have been attempts at bringing PDC materials, such as textbook chapters, lecture slides, assignments, and demos to assist instructors of early CS classes. However, the effort required on the part of the instructor to figure out what is relevant to a particular class can be daunting. In this work, we contend that simultaneously classifying pedagogical materials against the CS13 and the PDC12 curriculum guidelines can address some of the challenges faced by instructors and can promote broader adoption of PDC materials in early CS courses. We present CS Materials, a system that can be used to categorize pedagogical materials according to well-known and established curricular guidelines. We show that CS Materials can be leveraged 1) by instructors of early CS courses to find materials that are similar to the one that they use but that also cover PDC topics, and 2) by instructors to check the coverage of topics (and gaps) in a course, and 3) by PDC experts to identify topics for which PDC instructional materials do not exist or are insufficient in order to inform development of additional PDC curricular materials.
- Published
- 2021
9. Effects of travel technique and gender on a divided attention task in a virtual environment.
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Evan A. Suma, Samantha L. Finkelstein, Seth Clark, Paula Goolkasian, and Larry F. Hodges
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- 2010
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10. Selection performance based on classes of bimanual actions.
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Amy Catherine Ulinski, Zachary Wartell, Paula Goolkasian, Evan A. Suma, and Larry F. Hodges
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- 2009
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11. Social responses to virtual humans: implications for future interface design.
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Catherine A. Zanbaka, Amy Catherine Ulinski, Paula Goolkasian, and Larry F. Hodges
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- 2007
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12. Can a virtual cat persuade you?: the role of gender and realism in speaker persuasiveness.
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Catherine A. Zanbaka, Paula Goolkasian, and Larry F. Hodges
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- 2006
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13. Target Categorization with Primes that Vary in both Congruency and Modality.
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Kathryn Weatherford, Michael Mills, and Paula Goolkasian
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- 2014
14. Conceptual Priming with Pictures and Environmental Sounds.
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Paula Goolkasian, Yongju Kim, Anne Marie Porter, and Kathryn Weatherford
- Published
- 2013
15. Perceptual Comparisons with Pictures and Environmental Sounds.
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Paula Goolkasian and Alexandra Stubblefield
- Published
- 2011
16. Mapping Materials to Curriculum Standards for Design, Alignment, Audit, and Search
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Kalpathi Subramanian, Jamie Payton, Matthew Mcquaigue, Alec Goncharow, Erik Saule, and Paula Goolkasian
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Vocabulary ,Engineering management ,Resource (project management) ,Overhead (business) ,Computer science ,media_common.quotation_subject ,Workforce ,ComputingMilieux_COMPUTERSANDEDUCATION ,Quality (business) ,National curriculum ,Audit ,Curriculum ,media_common - Abstract
Computing proficiency is an increasingly vital component of the modern workforce, and computer science programs are faced with the challenges of engaging and retaining students to meet the growing need in that sector. However, administrators and instructors often find themselves either reinventing the wheel or relying too heavily on intuition, despite the availability of national curriculum standards. To address these issues, we present CS Materials, an open-source resource targeted at computing educators for designing and analyzing courses for coverage of recommended guidelines, and alignment between the various components within a course, between sections of the same course, or course sequences within a program. The system works by facilitating mapping educational materials to national curriculum standards. A side effect of the system is that it centralizes the design of the courses and the materials used therein. The curriculum guidelines act as a lingua franca that allows examination of and comparison between materials and courses. More relevant to instructors, the system enables a more precise search for materials that match particular topics and learning outcomes, and dissemination of high quality materials and course designs. This paper discusses the system, and analyzes the costs and benefits of its features and usage. While adding courses and materials requires some overhead, having a centralized repository of courses and materials with a shared structure and vocabulary serves students, instructors, and administrators, by promoting a data-driven approach to rigor and alignment with national standards.
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- 2021
17. Open vs. Closed Shapes: New Perceptual Categories?
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Paula Goolkasian, David Burlinson, and Kalpathi Subramanian
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Adult ,Male ,Visual perception ,Computer science ,media_common.quotation_subject ,Context (language use) ,02 engineering and technology ,050105 experimental psychology ,Plot (graphics) ,Young Adult ,Perception ,Task Performance and Analysis ,Computer Graphics ,Reaction Time ,0202 electrical engineering, electronic engineering, information engineering ,Humans ,0501 psychology and cognitive sciences ,media_common ,business.industry ,05 social sciences ,020207 software engineering ,Pattern recognition ,Numerosity adaptation effect ,Computer Graphics and Computer-Aided Design ,Feature (computer vision) ,Salient ,Signal Processing ,Visual Perception ,Female ,Optimal distinctiveness theory ,Computer Vision and Pattern Recognition ,Artificial intelligence ,business ,Software - Abstract
Effective communication using visualization relies in part on the use of viable encoding strategies. For example, a viewer's ability to rapidly and accurately discern between two or more categorical variables in a chart or figure is contingent upon the distinctiveness of the encodings applied to each variable. Research in perception suggests that color is a more salient visual feature when compared to shape and although that finding is supported by visualization studies, characteristics of shape also yield meaningful differences in distinctiveness. We propose that open or closed shapes (that is, whether shapes are composed of line segments that are bounded across a region of space or not) represent a salient characteristic that influences perceptual processing. Three experiments were performed to test the reliability of the open/closed category; the first two from the perspective of attentional allocation, and the third experiment in the context of multi-class scatterplot displays. In the first, a flanker paradigm was used to test whether perceptual load and open/closed feature category would modulate the effect of the flanker on target processing. Results showed an influence of both variables. The second experiment used a Same/Different reaction time task to replicate and extend those findings. Results from both show that responses are faster and more accurate when closed rather than open shapes are processed as targets, and there is more processing interference when two competing shapes come from the same rather than different open or closed feature categories. The third experiment employed three commonly used visual analytic tasks - perception of average value, numerosity, and linear relationships with both single and dual displays of open and closed symbols. Our findings show that for numerosity and trend judgments, in particular, that different symbols from the same open or closed feature category cause more perceptual interference when they are presented together in a plot than symbols from different categories. Moreover, the extent of the interference appears to depend upon whether the participant is focused on processing open or closed symbols.
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- 2018
18. Two Handed Selection Techniques for Volumetric Data.
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Amy Catherine Ulinski, Catherine A. Zanbaka, Zachary Wartell, Paula Goolkasian, and Larry F. Hodges
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- 2007
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19. A Textbook on Machine Hearing
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Paula Goolkasian
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medicine.medical_specialty ,medicine ,General Earth and Planetary Sciences ,Audiology ,Psychology ,General Environmental Science - Published
- 2017
20. Colavita dominance effect revisited: the effect of semantic congruity
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Lauryn A. Jacobs, Alexandra Stubblefield, Paula Goolkasian, and Yongju Kim
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Male ,Linguistics and Language ,Visual perception ,Adolescent ,genetic structures ,Experimental and Cognitive Psychology ,Sensory Systems ,Language and Linguistics ,Semantics ,Dominance (ethology) ,Acoustic Stimulation ,Auditory Perception ,Reaction Time ,Visual Perception ,Humans ,Attention ,Female ,Psychology ,Photic Stimulation ,Cognitive psychology - Abstract
To investigate the effect of semantic congruity on audiovisual target responses, participants detected a semantic concept that was embedded in a series of rapidly presented stimuli. The target concept appeared as a picture, an environmental sound, or both; and in bimodal trials, the audiovisual events were either consistent or inconsistent in their representation of a semantic concept. The results showed faster detection latencies to bimodal than to unimodal targets and a higher rate of missed targets when visual distractors were presented together with auditory targets, in comparison to auditory targets presented alone. The findings of Experiment 2 showed a cross-modal asymmetry, such that visual distractors were found to interfere with the accuracy of auditory target detection, but auditory distractors had no effect on either the speed or the accuracy of visual target detection. The biased-competition theory of attention (Desimone & Duncan Annual Review of Neuroscience 18: 1995; Duncan, Humphreys, & Ward Current Opinion in Neurobiology 7: 255–261 1997) was used to explain the findings because, when the saliency of the visual stimuli was reduced by the addition of a noise filter in Experiment 4, visual interference on auditory target detection was diminished. Additionally, the results showed faster and more accurate target detection when semantic concepts were represented in a visual rather than an auditory format.
- Published
- 2013
21. Too Close for (Brain) Comfort: Improving Science Vocabulary Learning in the Middle Grades
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Paula Goolkasian, Rebecca Shore, and Jenna Ray
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Science instruction ,Learning opportunities ,Teaching method ,Pedagogy ,Developmental and Educational Psychology ,Mathematics education ,Middle grades ,Psychology ,Vocabulary learning ,Vocabulary development ,Education - Abstract
(2013). Too Close for (Brain) Comfort: Improving Science Vocabulary Learning in the Middle Grades. Middle School Journal: Vol. 44, Active, Purposeful Learning Opportunities for All Students, pp. 16-21.
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- 2013
22. Latent viral immune inflammatory response model for chronic multisymptom illness
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Cdr Sean R. Maloney, Paula Goolkasian, Virginia Gil-Rivas, and Susan Jensen
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Inflammation ,Nervous system ,education.field_of_study ,business.industry ,Population ,Central nervous system ,General Medicine ,Models, Theoretical ,Acquired immune system ,medicine.anatomical_structure ,Immune system ,Antigen ,Chronic Disease ,Immunology ,medicine ,Humans ,medicine.symptom ,business ,education ,Glucocorticoid ,medicine.drug - Abstract
A latent viral immune inflammatory response (LVIIR) model is presented which integrates factors that contribute to chronic multisymptom illness (CMI) in both the veteran and civilian populations. The LVIIR model for CMI results from an integration of clinical experience with a review of the literature in four distinct areas: (1) studies of idiopathic multisymptom illness in the veteran population including two decades of research on Gulf War I veterans with CMI, (2) new evidence supporting the existence of chronic inflammatory responses to latent viral antigens and the effect these responses may have on the nervous system, (3) recent discoveries concerning the role of vitamin D in maintaining normal innate and adaptive immunity including suppression of latent viruses and regulation of the immune inflammatory response, and (4) the detrimental effects of extreme chronic repetitive stress (ECRS) on the immune and nervous systems. The LVIIR model describes the pathophysiology of a pathway to CMI and presents a new direction for the clinical assessment of CMI that includes the use of neurological signs from a physical exam, objective laboratory data, and a new proposed latent viral antigen–antibody imaging technique for the peripheral and central nervous system. The LVIIR model predicts that CMI can be treated by a focus on reversal of immune system impairment, suppression of latent viruses and their antigens, and healing of nervous system tissue damaged by chronic inflammation associated with latent viral antigens and by ECRS. In addition, the LVIIR model suggests that maintaining optimal serum 25 OH vitamin D levels will maximize immune system suppression of latent viruses and their antigens and will minimize immune system inflammation. This model also emphasizes the importance of decreasing ECRS to improve immune system function and to minimize nervous system injury from excess serum glucocorticoid levels. The proposed model supports growing evidence that increasing omega 3 essential fatty acid levels in nervous system tissues may decrease inflammation in the nervous system and improve neural plasticity and recovery from neuronal injury.
- Published
- 2013
23. BRIDGES
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Kalpathi Subramanian, Michael Youngblood, Robert Kosara, Chris Grafer, Paula Goolkasian, David Burlinson, Mihai Mehedint, and Jamie Payton
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Computer science ,business.industry ,020207 software engineering ,02 engineering and technology ,Construct (python library) ,Data structure ,Visualization ,Data set ,World Wide Web ,Software ,020204 information systems ,ComputingMilieux_COMPUTERSANDEDUCATION ,0202 electrical engineering, electronic engineering, information engineering ,business ,Real world data ,Implementation - Abstract
Although undergraduate enrollment in Computer Science has remained strong and seen substantial increases in the past decade, retention of majors remains a significant concern, particularly for students at the freshman and sophomore level that are tackling foundational courses on algorithms and data structures. In this work, we present BRIDGES, a software infrastructure designed to enable the creation of more engaging assignments in introductory data structures courses by providing students with a simplified API that allows them to populate their own data structure implementations with live, real-world, and interesting data sets, such as those from popular social networks (e.g., Twitter, Facebook). BRIDGES also provides the ability for students to create and explore {\em visualizations} of the execution of the data structures that they construct in their course assignments, which can promote better understanding of the data structure and its underlying algorithms; these visualizations can be easily shared via a weblink with peers, family, and instructional staff. In this paper, we present the BRIDGES system, its design, architecture and its use in our data structures course over two semesters.
- Published
- 2016
24. A Citizen Scientist’s Perspective on Perceiving ColorsA Citizen Scientist’s Perspective on Perceiving Colors
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Paula Goolkasian
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Perspective (graphical) ,Citizen science ,General Earth and Planetary Sciences ,Psychology ,Social psychology ,General Environmental Science ,Epistemology - Published
- 2016
25. Research in Visual Pattern Recognition: The Enduring Legacy of Studies From the 1960s
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Paula Goolkasian
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Publishing ,Cognitive science ,Visual perception ,Research ,media_common.quotation_subject ,Visual Physiology ,Historical Article ,Experimental and Cognitive Psychology ,History, 20th Century ,Pattern Recognition, Visual ,Arts and Humanities (miscellaneous) ,Visual Pattern Recognition ,Perception ,Pattern recognition (psychology) ,Visual patterns ,Developmental and Educational Psychology ,Cognitive Science ,Humans ,Periodicals as Topic ,Psychology ,Emphasis (typography) ,media_common - Abstract
This article highlights some research in visual pattern perception that was published in the American Journal of Psychology in the 1960s. Although visual perception research has changed substantially since then, and the term visual pattern recognition is no longer in widespread use, the six articles presented here are some of the most influential of those published by the Journal in its long history. The research is described with an emphasis on how a particular publication influenced others and the field in general.
- Published
- 2012
26. Interactive gaming reduces experimental pain with or without a head mounted display
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Catherine Zanbaka, Junaid S. Merchant, Nakia S. Gordon, Paula Goolkasian, and Larry F. Hodges
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medicine.medical_specialty ,Optical head-mounted display ,Virtual reality ,Affect (psychology) ,Pain rating ,Human-Computer Interaction ,Physical medicine and rehabilitation ,Arts and Humanities (miscellaneous) ,Positive emotion ,medicine ,Psychology ,human activities ,General Psychology ,Simulation - Abstract
While virtual reality environments have been shown to reduce pain, the precise mechanism that produces the pain attenuating effect has not been established. It has been suggested that it may be the ability to command attentional resources with the use of head mounted displays (HMDs) or the interactivity of the environment. Two experiments compared participants' pain ratings to high and low levels of electrical stimulation while engaging in interactive gaming with an HMD. In the first, gaming with the HMD was compared to a positive emotion induction condition; and in the second experiment the HMD was compared to a condition in which the game was projected onto a wall. Interactive gaming significantly reduced numerical ratings of painful stimuli when compared to the baseline and affect condition. However, when the two gaming conditions were directly compared, they equally reduced participants' pain ratings. These data are consistent with past research showing that interactive gaming can attenuate experimentally induced pain and its effects are comparable whether presented in a head mounted display or projected on a wall.
- Published
- 2011
27. Reliability, validity, and responsiveness of the Japanese version of the Neck Pain and Disability Scale
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Shunichi Fukuhara, Paula Goolkasian, Misa Takegami, Shinichi Kikuchi, Shinichi Konno, Anthony H. Wheeler, Rei Ono, Yoshimi Suzukamo, and Koji Otani
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Male ,medicine.medical_specialty ,Disability Evaluation ,Physical medicine and rehabilitation ,Japan ,Surveys and Questionnaires ,medicine ,Humans ,Orthopedics and Sports Medicine ,In patient ,Reliability (statistics) ,Language ,Pain Measurement ,Neck pain ,Neck Pain ,business.industry ,Reproducibility of Results ,Middle Aged ,RELIABILITY VALIDITY ,Test (assessment) ,Bodily pain ,Scale (social sciences) ,Orthopedic surgery ,Physical therapy ,Female ,Surgery ,medicine.symptom ,business - Abstract
Until recently, no Japanese versions have existed of the more popular, patient-reported disability questionnaires for neck pain. This study aimed to test the reliability, validity, and responsiveness of the Japanese version of the Neck Pain and Disability Scale (NPDS), one of the most widely used questionnaires in patients with neck pain.In this validation study, 167 outpatients with neck pain participated. Patients received the NPDS and the Medical Outcome Study Short Form 36-item Health Survey (SF-36), and used Visual Analog Scales (VASs) to assess pain and global health. To examine test-retest reliability, patients who were considered stable by clinicians were given the NPDS 2 weeks after baseline. To examine responsiveness, patients who had not undergone treatment at the time of the first data collection or had no change in treatment over 3 months were studied again 2 weeks after starting a new medication or physical therapy.Of the 167 participants, 143 completed the questionnaires (85.6%). Factor analysis showed two factors, defined as neck-pain-related disability (factor 1) and neck-related pain (factor 2). Cronbach's α coefficient for factor 1, factor 2, and total score was 0.94, 0.93, and 0.96. The intra-class correlation coefficients for the 19 more stable patients were 0.79, 0.88, and 0.87. For concurrent validity, the correlation between NPDS subscales and total score and SF-36 subscale scores ranged from r = -0.54 to -0.22 (p 0.01). Correlations between the NPDS subscales and total score and VAS of pain ranged from 0.56 to 0.77 (p 0.01) and those for VAS of global health ranged from 0.48 to 0.63 (p 0.01). The NPDS subscales and total scores of the 41 patients retested after treatment were significantly improved.The Japanese version of the NPDS is a useful scale with reliability, validity, and responsiveness in assessing patients suffering from neck pain.
- Published
- 2011
28. Effects of Brief and Sham Mindfulness Meditation on Mood and Cardiovascular Variables
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Nakia S. Gordon, Fadel Zeidan, Susan K. Johnson, and Paula Goolkasian
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Adult ,Male ,Mindfulness ,media_common.quotation_subject ,Blood Pressure ,Anxiety ,Profile of mood states ,Affect (psychology) ,Placebo ,Cardiovascular Physiological Phenomena ,Young Adult ,Heart Rate ,Intervention (counseling) ,medicine ,Humans ,Meditation ,Fatigue ,media_common ,Depression ,Mind-Body Therapies ,business.industry ,Placebo Effect ,Affect ,Mood ,Complementary and alternative medicine ,Female ,medicine.symptom ,business ,Stress, Psychological ,Clinical psychology - Abstract
Although long-term meditation has been found to reduce negative mood and cardiovascular variables, the effects of a brief mindfulness meditation intervention when compared to a sham mindfulness meditation intervention are relatively unknown. This experiment examined whether a 3-day (1-hour total) mindfulness or sham mindfulness meditation intervention would improve mood and cardiovascular variables when compared to a control group.Eighty-two (82) undergraduate students (34 males, 48 females), with no prior meditation experience, participated in three sessions that involved training in either mindfulness meditation, sham mindfulness meditation, or a control group. Heart rate, blood pressure, and psychologic variables (Profile of Mood States, State Anxiety Inventory) were assessed before and after the intervention.The meditation intervention was more effective at reducing negative mood, depression, fatigue, confusion, and heart rate, when compared to the sham and control groups.These results indicate that brief meditation training has beneficial effects on mood and cardiovascular variables that go beyond the demand characteristics of a sham meditation intervention.
- Published
- 2010
29. Mindfulness meditation improves cognition: Evidence of brief mental training
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Bruce J. Diamond, Paula Goolkasian, Susan K. Johnson, Fadel Zeidan, and Zhanna David
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Male ,Mindfulness ,Psychotherapist ,media_common.quotation_subject ,education ,Short-term memory ,Experimental and Cognitive Psychology ,Executive Function ,Young Adult ,Cognition ,Arts and Humanities (miscellaneous) ,Developmental and Educational Psychology ,medicine ,Humans ,Verbal fluency test ,Attention ,Meditation ,media_common ,Psychological Tests ,Negotiating ,Working memory ,Awareness ,Affect ,Memory, Short-Term ,Mood ,Anxiety ,Female ,medicine.symptom ,Psychology - Abstract
Although research has found that long-term mindfulness meditation practice promotes executive functioning and the ability to sustain attention, the effects of brief mindfulness meditation training have not been fully explored. We examined whether brief meditation training affects cognition and mood when compared to an active control group. After four sessions of either meditation training or listening to a recorded book, participants with no prior meditation experience were assessed with measures of mood, verbal fluency, visual coding, and working memory. Both interventions were effective at improving mood but only brief meditation training reduced fatigue, anxiety, and increased mindfulness. Moreover, brief mindfulness training significantly improved visuo-spatial processing, working memory, and executive functioning. Our findings suggest that 4 days of meditation training can enhance the ability to sustain attention; benefits that have previously been reported with long-term meditators.
- Published
- 2010
30. The Effects of Brief Mindfulness Meditation Training on Experimentally Induced Pain
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Nakia S. Gordon, Paula Goolkasian, Fadel Zeidan, and Junaid S. Merchant
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Adult ,Male ,Pain Threshold ,medicine.medical_specialty ,Time Factors ,Mindfulness ,Adolescent ,media_common.quotation_subject ,education ,Analgesic ,Pain ,Anxiety ,Neuropsychological Tests ,Relaxation Therapy ,Audiology ,Stimulus (physiology) ,behavioral disciplines and activities ,Thinking ,Young Adult ,Cognition ,Mental Processes ,Distraction ,medicine ,Humans ,Pain Management ,Attention ,Meditation ,Pain Measurement ,media_common ,Teaching ,Electric Stimulation ,Anesthesiology and Pain Medicine ,Neurology ,Mindfulness meditation ,Female ,Neurology (clinical) ,medicine.symptom ,Psychology ,Mathematics ,psychological phenomena and processes ,Clinical psychology - Abstract
This study investigated the effects of brief mindfulness meditation training on ratings of painful electrical stimulation. In Experiment 1, we used a 3-day (20 min/d) mindfulness meditation intervention and measured pain ratings before and after the intervention. Participants' numerical rat- ings of pain to ''low'' and ''high'' electrical stimulation significantly decreased after meditation train- ing. Pain sensitivity, measured by change in stimulus intensity thresholds, also decreased after training. We investigated, in Experiment 2, how well relaxation and a math distraction task attenu- ated experimental pain. Math distraction but not relaxation reduced high pain ratings. There was no reduction in pain sensitivity in these participants. In Experiment 3, we directly compared the effects of meditation with math distraction and relaxation conditions. Our findings indicated significant ef- fects of both meditation and math distraction. Consistent with what was observed in Experiment 1, these participants also demonstrated a decrease in pain sensitivity after meditation training. Changes in the mindfulness and anxiety assessments suggest that meditation's analgesic effects are related to reduced anxiety and the enhanced ability to focus on the present moment. Perspective: Our findings indicate that a brief 3-day mindfulness meditation intervention was ef- fective at reducing pain ratings and anxiety scores when compared with baseline testing and other cognitive manipulations. The brief meditation training was also effective at increasing mindfulness skills.
- Published
- 2010
31. Mirror Neurons: The Complete Story
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Paula Goolkasian
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Gender Studies ,Arts and Humanities (miscellaneous) ,Experimental and Cognitive Psychology ,Psychology ,Neuroscience ,Mirror neuron - Published
- 2009
32. Reduction and Elimination of Format Effects on Recall
- Author
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Paula Goolkasian, Daniel C. Krusemark, and Paul W. Foos
- Subjects
Letter case ,Recall ,Working memory ,business.industry ,Memoria ,media_common.quotation_subject ,Recall test ,Experimental and Cognitive Psychology ,computer.software_genre ,Linguistics ,Presentation ,Free recall ,Arts and Humanities (miscellaneous) ,Developmental and Educational Psychology ,Artificial intelligence ,Psychology ,business ,computer ,Natural language processing ,Sentence ,media_common - Abstract
Two experiments investigated whether the recall advantage of pictures and spoken words over printed words in working memory (Foos & Goolkasian, 2005; Goolkasian & Foos, 2002) could be reduced by manipulating letter case and sequential versus simultaneous presentation. Participants were required to remember 3 or 6 items presented in varied presentation formats while verifying the accuracy of a sentence. Presenting words in alternating uppercase and lowercase improved recall, and presenting words simultaneously rather than successively removed the effect of presentation format. The findings suggest that when forcing participants to pay attention to printed words you can make them more memorable and thereby diminish or remove any disadvantage in the recall of printed words in comparison with pictures and spoken words.
- Published
- 2008
33. Presentation Format Effects in a Levels-of-Processing Task
- Author
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Paul W. Foos and Paula Goolkasian
- Subjects
Adult ,Male ,Semantic link ,Computer science ,Experimental and Cognitive Psychology ,Stimulus (physiology) ,computer.software_genre ,Arts and Humanities (miscellaneous) ,Memory ,Reaction Time ,Humans ,Semantic memory ,Visual short-term memory ,Memory test ,Levels-of-processing effect ,General Psychology ,Recognition memory ,business.industry ,Recognition, Psychology ,General Medicine ,Attention model ,Female ,Artificial intelligence ,business ,computer ,Natural language processing ,Cognitive psychology - Abstract
Three experiments were conducted to examine better performance in long-term memory when stimulus items are pictures or spoken words compared to printed words. Hypotheses regarding the allocation of attention to printed words, the semantic link between pictures and processing, and a rich long-term representation for pictures were tested. Using levels-of-processing tasks eliminated format effects when no memory test was expected and processing was deep (E1), and when study and test formats did not match (E3). Pictures produced superior performance when a memory test was expected (E1 & 2) and when study and test formats were the same (E3). Results of all experiments support the attenuation of attention model and that picture superiority is due to a more direct access to semantic processing and a richer visual code. General principles to guide the processing of stimulus information are discussed.
- Published
- 2008
34. Target categorization with primes that vary in both congruency and sense modality
- Author
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Paula Goolkasian, Michael Mills, Kathryn Weatherford, and Anne Marie Porter
- Subjects
media_common.quotation_subject ,lcsh:BF1-990 ,Repetition priming ,perception ,computer.software_genre ,semantic processing ,Superordinate goals ,Perception ,Semantic memory ,Psychology ,Original Research Article ,categorization task ,conceptual priming ,General Psychology ,media_common ,Response priming ,Modality (human–computer interaction) ,business.industry ,cross-modal ,lcsh:Psychology ,Categorization ,Artificial intelligence ,business ,Priming (psychology) ,computer ,Natural language processing ,Cognitive psychology - Abstract
In two experiments we examined conceptual priming within and across sense modalities by varying the modality (picture and environmental sounds) and the category congruency of prime-target pairs. Both experiments used a repetition priming paradigm, but Experiment 1 studied priming effects with a task that required a superordinate categorization response (man-made or natural), while Experiment 2 used a lower-level category response (musical instruments or animal): one that was more closely associated with the basic level of the semantic network. Results from Experiment 1 showed a strong effect of target modality and two distinct patterns of conceptual priming effects with picture and environmental sound targets. However, no priming advantage was found when congruent and incongruent primes were compared. Results from Experiment 2, found congruency effects that were specific to environmental sound targets when preceded by picture primes. The findings provide support for the intermodal event file and multisensory framework, and suggest that auditory and visual features about a single item in a conceptual category may be more tightly connected than two different items from the same category.
- Published
- 2015
- Full Text
- View/download PDF
35. In-Coming Executive Editors' Editorial Statement
- Author
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Paula Goolkasian, Janet M. Gibson, and Andrea M. Karkowski
- Subjects
Gender Studies ,Arts and Humanities (miscellaneous) ,Statement (logic) ,Law ,Experimental and Cognitive Psychology ,Psychology - Published
- 2005
36. Bimodal Format Effects in Working Memory
- Author
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Paula Goolkasian and Paul W. Foos
- Subjects
Arts and Humanities (miscellaneous) ,Developmental and Educational Psychology ,Experimental and Cognitive Psychology - Abstract
This work combines presentation formats to test whether bimodal conditions offer advantages or disadvantages relative to single formats in working memory performance. A dual task that included recall of 3 or 6 items while verifying the accuracy of math sentences was used in 2 experiments. When comparisons were made between single- and dual-format conditions, there was an advantage for items presented as spoken words and pictures simultaneously and individually. In Experiment 2, dual-format conditions had incongruent information, and spoken words were found to interfere with recall of long sequences of pictures and printed words. The findings suggest that when dual-format items are the same, there are some performance advantages when spoken words are combined with pictures or printed words. When the dual formats are displaying different items, however, spoken words are a more powerful distractor than pictures or printed words, and verbal and visual short-term stores can demonstrate similar susceptibility to distractor interference.
- Published
- 2005
37. Visual Search: The Effects of Display and Response Format
- Author
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Paula Goolkasian, Stephen D. Christman, and Janae N. Lockett-Reynolds
- Subjects
Visual search ,Computer science ,business.industry ,education ,Spatial encoding ,behavioral disciplines and activities ,humanities ,Task (project management) ,Display device ,Medical Terminology ,Human–computer interaction ,Computer vision ,Artificial intelligence ,business ,Medical Assisting and Transcription - Abstract
The present experiment examined how spatial judgments influenced target detection in a visual search task. Digital and analogue display formats were studied together with odd/even vs. above/below judgments. The results indicated an overall advantage for digital display formats, however, the advantage was mediated by the type of judgments that were made. Format differences were minimal when individuals were required to make judgments that involved spatial encoding. Ergonomic implications are addressed.
- Published
- 2003
38. Neck Pain and Disability Scale: a critical evaluation
- Author
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Paula Goolkasian
- Subjects
medicine.medical_specialty ,Neck pain ,business.industry ,Health Policy ,Chronic pain ,General Medicine ,Outcome assessment ,medicine.disease ,Physical medicine and rehabilitation ,Scale (social sciences) ,Physical therapy ,Medicine ,Pharmacology (medical) ,medicine.symptom ,business - Abstract
This report provides a review of the current procedures for measuring cervical pain and dysfunction and discusses some of the methodological issues involved in the measurement of chronic pain. In particular, the Neck Pain and Disability Scale is compared with other measures of pain and disability. Suggestions are made for further documentation of clinical and research usefulness.
- Published
- 2003
39. Evaluation of a Web Site in Cognitive Science
- Author
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Lori R. Van Wallendael, Paula Goolkasian, and Jane F. Gaultney
- Subjects
Cognitive science ,Class (computer programming) ,business.industry ,05 social sciences ,Attendance ,050301 education ,050109 social psychology ,Predictor variables ,Education ,ComputingMilieux_COMPUTERSANDEDUCATION ,0501 psychology and cognitive sciences ,The Internet ,Science curriculum ,Psychology ,business ,0503 education ,General Psychology ,Web site - Abstract
A public Web site (Goolkasian & Van Wallendael, 2001), established to provide educational materials in cognitive science, served as the primary text for an interdisciplinary course. We tracked student use of the Web site online and with self-report questionnaires. A majority (74%) of the students rated the Web site to be as useful or more useful than a traditional textbook. Although time spent online with the Web materials predicted scores for 2 of the 4 exams, class attendance was the strongest predictor of exam performance.
- Published
- 2003
40. Presentation format and its effect on working memory
- Author
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Paula Goolkasian and Paul W. Foos
- Subjects
Male ,Experimental and Cognitive Psychology ,computer.software_genre ,Task (project management) ,Random Allocation ,Cognition ,Arts and Humanities (miscellaneous) ,Memory ,Memory span ,Humans ,Modality (human–computer interaction) ,Recall ,business.industry ,Working memory ,Neuropsychology and Physiological Psychology ,Female ,Artificial intelligence ,business ,Psychology ,computer ,Photic Stimulation ,Word (computer architecture) ,Sentence ,Natural language processing ,Cognitive psychology - Abstract
In three experiments, we examined the separate cognitive demands of processing and storage in working memory and looked at how effective the coordination was when items for storage varied in format/modality. A sentence verification task involving arithmetic facts was combined with a span task involving two to six items presented in picture, printed word, or spoken word format. The first two experiments were the same, except for the added requirement of articulation of the math sentence in Experiment 2. Experiment 3 varied the length of the span item and compared recall with recognition performance. The results showed that both spoken words and pictures produced superior recall and recognition, as compared with printed words, and are consistent with Baddeley and Logie’s (1999) and Mayer’s (2001) models of working memory. Also, the differences in processing performance across spans varied with the difficulty of the task but showed the strongest support for the resource allocation model (Foos, 1995).
- Published
- 2002
41. The Neck Pain and Disability Scale: Test–Retest Reliability and Construct Validity
- Author
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Stephanie S. Gretz, Paula Goolkasian, and Anthony H. Wheeler
- Subjects
Adult ,Male ,medicine.medical_specialty ,Scale test ,Sensitivity and Specificity ,Disability Evaluation ,Physical medicine and rehabilitation ,Surveys and Questionnaires ,Humans ,Medicine ,Treatment effect ,Reliability (statistics) ,Pain Measurement ,Analysis of Variance ,Neck pain ,Pain experience ,Neck Pain ,business.industry ,Outcome measures ,Reproducibility of Results ,Construct validity ,Treatment Outcome ,Anesthesiology and Pain Medicine ,Scale (social sciences) ,Physical therapy ,Female ,Neurology (clinical) ,medicine.symptom ,business ,Follow-Up Studies - Abstract
Objective This research established test-retest reliability and construct validity for the Neck Pain and Disability Scale (NPAD). Methods Two groups of patients with neck pain completed the NPAD. The first group filled out the scale twice before treatment, whereas the second completed it with a number of other outcome measures once a month for 4 months, for evaluation of treatment with injections. Results The reliability coefficient (r2 = 0.93) calculated from the data for the first group of patients indicated high test-retest reliability. Construct validity was demonstrated with the second group when the NPAD was compared with a number of other pain measures and found to have a larger treatment effect. The Neck Pain and Disability Scale factor scores also indicated that treatment effects varied across the four factors. Conclusions The NPAD is a stable and responsive measure for patients with neck pain. The Neck Pain and Disability Scale factor scores are useful in identifying treatment effects on the specific dimensions involved in the pain experience.
- Published
- 2002
42. Open vs Closed Shapes: A Dimension of Perceptual Awareness?
- Author
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David Burlinson, Kalpathi Subramanian, and Paula Goolkasian
- Subjects
Ophthalmology ,Dimension (vector space) ,Perception ,media_common.quotation_subject ,Psychology ,Social psychology ,Sensory Systems ,Cognitive psychology ,media_common - Published
- 2017
43. A Top-Down Approach to Machine Vision: From Machine to Human Vision and Beyond
- Author
-
Paula Goolkasian
- Subjects
Computer science ,business.industry ,Machine vision ,General Earth and Planetary Sciences ,Computer vision ,Top-down and bottom-up design ,Artificial intelligence ,business ,General Environmental Science - Published
- 2014
44. Botulinum toxin A for the treatment of chronic neck pain
- Author
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Stephanie S. Gretz, Paula Goolkasian, and Anthony H. Wheeler
- Subjects
Adult ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,law.invention ,Disability Evaluation ,Randomized controlled trial ,law ,medicine ,Humans ,Botulinum Toxins, Type A ,Adverse effect ,Saline ,Pain Measurement ,Neck pain ,Neck Pain ,business.industry ,Incidence (epidemiology) ,Chronic pain ,Middle Aged ,medicine.disease ,Botulinum toxin ,Surgery ,Clinical trial ,Treatment Outcome ,Anesthesiology and Pain Medicine ,Neuromuscular Agents ,Neurology ,Anesthesia ,Chronic Disease ,Female ,Neurology (clinical) ,medicine.symptom ,business ,medicine.drug - Abstract
A clinical study tested the therapeutic efficacy of Botulinum toxin A (BTXA) when injected into symptomatic neck muscles after one injection session. Patients with chronic neck pain were randomly assigned to receive either a high dose of an active treatment or an injection of the same volume of normal saline. Patients were compared for 4 months using a comprehensive set of outcome measures that included the Neck Pain and Disability Scale (Spine 24 (1999) 1290) and pressure algometry (Arch Phys Med Rehabil 67 (1986) 406; Pain 30 (1987) 115; Clin J Pain 2 (1987) 207). Analyses were consistent in showing significant benefits from the injection session; however, the effects were not specific to the group treated with BTXA. Both treatment and control groups showed a significant decline in pain and disability across time and an increased ability to withstand pressure on trigger points. The heavy incidence of adverse events in the treatment group may partly explain the absence of a treatment effect specific to BTXA. The results show that a single dose treatment without physical therapy is not effective for chronic neck pain.
- Published
- 2001
45. A Web site in cognitive science
- Author
-
Paula Goolkasian and Lori R. Van Wallendael
- Subjects
Cognitive science ,Internet ,Multimedia ,Computer science ,Teaching ,media_common.quotation_subject ,Perspective (graphical) ,Distance education ,Experimental and Cognitive Psychology ,computer.software_genre ,Reading (process) ,ComputingMilieux_COMPUTERSANDEDUCATION ,Virtual Laboratory ,Cognitive Science ,Humans ,Psychology (miscellaneous) ,computer ,General Psychology ,media_common ,Web site - Abstract
A Web site (http://web2-pc.uncc.edu/cogsci) has been established to support an interdisciplinary course in cognitive science. The modules include introductory reading material, interactive exercises/virtual laboratory, and pointers to existing material on the Web. Our approach to using the Web in support of instruction differs from distance learning initiatives because it is centered on an instructor and classroom experiences. The Web-based modules are used to supplement classroom lectures and provide an interdisciplinary perspective.
- Published
- 2001
46. Open Label Assessment of Botulinum Toxin A for Pain Treatment in a Private Outpatient Setting
- Author
-
Paula Goolkasian and Anthony H. Wheeler
- Subjects
business.industry ,Medical record ,Myofascial pain syndrome ,medicine.disease ,Botulinum toxin ,Botulinum toxin a ,Rheumatology ,Refractory ,Anesthesia ,Cohort ,medicine ,Outpatient setting ,Open label ,business ,medicine.drug - Abstract
Objective: To determine efficacy and injection characteristics of botulinum toxin A [BTXA] treatment for refractory muscular pain in a private outpatient setting.Methods: Medical records were analyzed retrospectively for a sample 44-patient cohort who received BTXA injections for refractory muscular pain between 1/1/96 and 12/31/98.Results: Eighty percent of all patients reported reduced pain from the initial BTXA treatment. Thirty-two percent required one repeat injection and 27% received three or more.Conclusion: These data suggest that BTXA may reduce focal muscular pain, and in many cases, the benefit outlasts the expected action of the toxin.
- Published
- 2001
47. Location constancy and its effect on visual selection
- Author
-
Paula Goolkasian and Agnieszka Bojko
- Subjects
Cued speech ,genetic structures ,media_common.quotation_subject ,Experimental and Cognitive Psychology ,Space perception ,Cognition ,Retina ,Form Perception ,Covert ,Foveal ,Perception ,Statistics ,Reaction Time ,Humans ,Visual attention ,Computer Vision and Pattern Recognition ,Selective attention ,Visual Fields ,Psychology ,Social psychology ,Vision, Ocular ,media_common - Abstract
The present study investigated how location constancy influences selective attention to a cued location. The relative effectiveness of target/distractor distance and target/distractor compatibility were studied under covert and overt attention conditions. Experiment 1 measured reaction time and error rates to a scaled target letter that appeared at varied locations from 0.62 to 20 deg. Experiments 2 and 3 looked at covert/overt attention when the target location was fixed rather than varied within a block of trials. To provide a comprehensive assessment of the two primary variables across location constancy conditions, effect sizes for these results as well as for related past research (Goolkasian, 1999; Goolkasian and Tarantino, 1999) are presented. The findings suggest that the location of the target (foveal vs peripheral) does not influence attentional patterns as much as the consistency of its location. When a target appears at varied locations from trial to trial, distractor compatibility effects are in general stronger than the effect of target/distractor distance. However, the relative importance of these two variables reverses when the presentation location of the target is fixed at a constant location.
- Published
- 2001
48. Pictures, Words, and Sounds: From Which Format Are We Best Able to Reason?
- Author
-
Paula Goolkasian
- Subjects
Male ,Background information ,Communication ,business.industry ,Speech recognition ,Decision Making ,education ,Experimental and Cognitive Psychology ,Stimulus (physiology) ,Vocabulary ,Gender Studies ,Random Allocation ,Sound ,Arts and Humanities (miscellaneous) ,Reaction Time ,Humans ,Female ,Psychology ,business ,Photic Stimulation ,Sentence - Abstract
The effect of presentation format on reasoning was studied with a sentence verification task. Background information was presented in single-format and combined conditions that included pictured, printed, or spoken versions of the stimulus items. In Experiment 1, a test sentence appeared together with the background at varied stimulus onset asynchronies, to study how format influences the acquisition of the stimulus information. In Experiments 2 and 3, however, the test sentence followed the presentation of the background, to test the effect of format on memory. Reaction time responses to the test sentences showed a consistent picture advantage. However, when participants responded to materials stored in memory, both pictured and spoken formats provided quicker responses in comparison to printed words, and the format difference was smaller than when materials were readily available on the screen. Multimedia presentations, when compared with single-format conditions, did not provide additional ben...
- Published
- 2000
49. Book Review
- Author
-
Paula Goolkasian
- Subjects
Gender Studies ,Arts and Humanities (miscellaneous) ,Experimental and Cognitive Psychology - Published
- 2007
50. A Randomized, Double-Blind, Prospective Pilot Study of Botulinum Toxin Injection for Refractory, Unilateral, Cervicothoracic, Paraspinal, Myofascial Pain Syndrome
- Author
-
Paula Goolkasian, Stephanie S. Gretz, and Anthony H. Wheeler
- Subjects
Adult ,myalgia ,medicine.medical_specialty ,Visual analogue scale ,Pilot Projects ,Myofascial pain syndrome ,Placebo ,medicine.disease_cause ,law.invention ,Double-Blind Method ,Randomized controlled trial ,law ,medicine ,Humans ,Orthopedics and Sports Medicine ,Prospective Studies ,Botulinum Toxins, Type A ,Prospective cohort study ,Myofascial Pain Syndromes ,Pain Measurement ,Neck pain ,Neck Pain ,business.industry ,medicine.disease ,Surgery ,Neuromuscular Agents ,Anesthesia ,Clostridium botulinum ,Neurology (clinical) ,medicine.symptom ,business - Abstract
Study design In a randomized, double-blind study, two dosage strengths of botulinum toxin type A were compared with normal saline injected into symptomatic trigger points in the cervicothoracic paraspinal muscles. Objectives To compare the effect of botulinum toxin type A injections with that of normal saline to determine the former's usefulness in the management of neck pain and disability. Summary of background data The results of several studies have suggested that botulinum toxin type A may reduce pain associated with myofascial pain syndromes. Methods Thirty-three participants were divided randomly to receive either 50 or 100 units of botulinum toxin type A, or normal saline. Patients were re-evaluated over a 4-month period by assessment of their pain and disability and pressure algometer readings, and then offered a second injection of 100 units of botulinum toxin type A. Results All three groups showed significant treatment effects as measured by a decline in the scores on the Neck Pain and Disability Visual Analogue Scale and an increase in the pressure algometer scores. Group differences were apparent only when the authors considered the number of patients who were asymptomatic as a result of the injections. Conclusions Although no statistically significant benefit of botulinum toxin type A over placebo was demonstrated in this study, the high incidence of patients who were asymptomatic after a second injection suggests that further research is needed to determine whether higher dosages and sequential injections in a larger cohort might show a botulinum toxin type A effect.
- Published
- 1998
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