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Performance tracking devices in the form of wrist-worn watches are common in rowing; however, the accuracy of relevant output variables (i.e. stroke rate [SR] and velocity) during on-water training is unknown. To assess the quality of wrist-watch data output, 16 rowing athletes recorded 118 on-water rowing sessions using a Garmin Forerunner 735XT, which was compared to a Catapult Optimeye R4 tracking device. Garmin recording function was set to 'Every Second' (N = 68 sessions) or 'Smart' (N = 50 sessions). Catapult velocity was calculated as the average velocity per stroke, while a 15 s velocity moving average was determined for Garmin data. Catapult and Garmin were filtered for training-specific data (SR = 14–50 strokes per minute [spm]; velocity = 2.1–7.0 m/s−1). Efficacy and reliability of the Garmin was assessed via the difference between devices (% error), intra-class correlation coefficient (ICC ± 95% confidence interval (CI)) and coefficient of variation (CV%). Error in 15 s smoothed velocity was 3.8% ('Every Second') and 8.2% ('Smart'). Both recording functions demonstrated 'good' reliability (ICC = 0.75–0.9, CV < 10%) for SR and velocity; the exception was SR using 'Smart' recording. Our data suggests that when using the 'Every Second' recording function, data is filtered and velocity is smoothed over 15 s, the Garmin device can be reliable for SR and velocity measurement within 1 spm and <0.20 m/s−1 respectively. [ABSTRACT FROM AUTHOR]

This investigation explored differences in the pre-tournament preparation period relative to the movement demands of the Tokyo 2020 Olympic Games for the Australian male field-hockey team. Movement data was collected over 7 months prior to and during the 13-day Olympic tournament. Duration, distance (total; >80% individual peak velocity; >5 m.s−1), high-speed decelerations (>3.5 m.s−2), and total accelerations and decelerations (>2.5 m.s−2) were measured during each running-based session. A 13-day moving sum was calculated for each variable and compared to a player-specific "worst-case scenario" (WCS) for intra-tournament total movement demands. Summed 13-day movement demands exceeded the WCS for 6–58% of the preparation period across variables, for the entire squad. During the tournament, midfielders covered significantly greater sprint distance than Defenders (+84%,p = 0.020), with no other positional differences found. Greater variation in tournament movement demands was observed between players for accelerations, decelerations, and high-speed distance (CV = 19–46%) compared to duration and distance (CV = 4–9%). In conclusion, physical preparation exposed athletes to movement demands which surpassed WCS. Additionally, gross measures of training volume (duration and distance) are more generalisable to a squad; however, additional metrics such as sprint distance and high-speed decelerations are needed to better define positional and individual movement demands, and therefore, should be monitored by practitioners. [ABSTRACT FROM AUTHOR]

Preventing US workplace violence is especially relevant since the terrorist attacks of Sep 11, 2001.

The National Consortium for Environmental Education and Training has developed a guide to help schools implement environmental courses. The EE Toolbox contains a teacher's manual, instructions for accessing an on-line resource, a slide resource kit and a set of articles compiled from previous NCEET workshops. The teacher's manual dwells on definitions of environmental education, ways of integrating issues into the curriculum, the use of technology, and methods for devising locally-appropriate programs., Environmental education can fit any lesson plan The 1990 National Environmental Education Act provides federal funding for preparing educators to teach about the environment. Since its inception in 1992, the [...]

Objective: Few data exist on cognitive and depressive symptoms and vascular factors in American Indian (AI) elders. Since vascular risk factors increase risk for cognitive impairments, depression and dementia, and since AI elders are at high vascular risk, it is timely to assess the interplay of these factors in comprehensive studies of aging in this population. To begin, pilot studies must be conducted to show these types of data can be collected successfully.Design: A cross-sectional pilot study, the Southwest Heart Mind Study (SHMS).Setting: Tribal community in the Southwest United States.Participants: AI elders, aged ≥55 years.Main Outcome Measures: Cross-cultural demographic, social network and risk factor surveys; tests of cognition, depression and anxiety; physical measurements; blood biochemistries; and APOE genotyping.Results: SHMS elders were comparable to other rural elder populations on cognitive and depressive symptom scores. The average CogScore was 28.8 (out of 32), the average Geriatric Depression Scale (GDS) was 6.7 (of 30), and the average Hamilton Anxiety Scale was 1.2 (of 4). 32% possessed at least one APOEe4 allele. High vascular risk was evident: 76% were overweight or obese; 54% self-reported history of hypertension; 24% heart trouble; 32% type 2 diabetes; 35% depression; and 24% a family history of serious memory loss. More than 70% reported prescription medication use. 54% cared for someone besides self.Conclusions: A better understanding of the burden of vascular risk in relation to cognition and depression among Southwest Tribes is needed. [ABSTRACT FROM AUTHOR]

Der Beitrag widmet sich mit der Auseinandersetzung zwischen dem Deutschen Orden und dem Königreich Polen im frühen 15. Jahrhundert. Im Fokus stehen hierbei weniger die Austragung des Konflikts auf dem Konstanzer Konzil und die Berufung der Deputierten in der Diskussion auf die Autorität des Konzils. Vielmehr werden diplomatische Einflüsse ausübender „Drittakteure“ beleuchtet, wie etwa der Heilige Stuhl, der König und die Fürsten des Heiligen Römischen Reiches. Den groben zeitlichen Orientierungsrahmen bilden hier der sogenannte „Große Krieg“ 1409–1411 und der Frieden von Melnosee 1422.

We report on our investigation of low-energy pion-nucleon scattering from lattice QCD with Wilson type fermions. Our focus is on the isospin I = 3/2 channel, which couples to the Delta resonance. We discuss our calculations aiming at the extraction of the Delta resonance mass, width and effective coupling at pion mass 250 MeV, using the Lüscher finite-volume method to extract the phase shift δJ=3/2,l=1.

Excess N fertilization to achieve high crop yield is a grand old practice in developing countries. However, inorganic nutrient sources considerably replenish soil organic C (SOC). In the present study, we applied six different levels of N keeping P and K constant for maize, grown under maize (Zea mays) - dhaincha (Sesbania aculeata) cropping sequence. We recorded high crop yield, profuse root biomass and SOC stock with increasing N fertilization. Moreover, water holding capacity, microbial biomass carbon and particulate organic carbon improved significantly with increasing levels of N. Conversely, bulk density, mineral associated organic carbon and pH decreased with increasing application of inorganic N. Furthermore, a significant positive correlation was recorded between root biomass and soil organic carbon. A study of the sensitivity index showed particulate organic carbon and microbial biomass carbon to be good indicators of nutrient management practices. Dhaincha cultivation accelerated C and N mineralization in soil, which is reflected in increased biomass and crop yield. Hence, we conclude that inorganic N fertilization rate (7280 kg ha-1) in maize-dhaincha cropping sequence successfully maintains the SOC balance and optimize N stock in soil.

The present experiment was conducted with two common pulse crops namely black gram (Vigna mungo L.) and green gram (Vigna radiata L.) with the objective to study the morpho-physiological changes that took place in response to low moisture stress. Parameters such as plant height, leaf number, leaf area and pod number were studied under moisture stress condition as well as subsequent recovery stages. At harvest, yields of these two crops were recorded and various yield indexes like drought susceptibility index, drought tolerance index, mean and productivity rate were calculated. The study revealed that moisture stress has a significant impact on all these parameters in both crops. The effect was more significant in green gram compared to black gram. From the findings it is observed that moisture stress during flowering stage is detrimental for yield of the pulse crops and re-watering does not have a significant impact on yield improvement. Black gram variety T9 and green gram variety Pratap were identified as drought-tolerant varieties.

We present a high-statistics analysis of the ρ resonance in ππ scattering, using 2 + 1 flavors of clover fermions at a pion mass of approximately 320 MeV and a lattice size of approximately 3:6 fm. The computation of the two-point functions are carried out using combinations of forward, sequential, and stochastic propagators. For the extraction of the ρ-resonance parameters, we compare different fit methods and demonstrate their consistency. For the ππ scattering phase shift, we consider different Breit-Wigner parametrizations and also investigate possible nonresonant contributions. We find that the minimal Breit-Wigner model is suffcient to describe our data, and obtain amρ = 0:4609(16)stat(14)sys and gρππ = 5:69(13)stat(16)sys. In our comparison with other lattice QCD results, we consider the dimensionless ratios amρ/amN and amπ/amN to avoid scale setting ambiguities.

Context: Recent studies show increasing use of mechanical ventilation among people living with dementia. There are concerns that this trend may not be driven by patient preferences., Objectives: To better understand decision-making regarding mechanical ventilation in people living with dementia., Methods: This was an electronic health record-based retrospective cohort study of older adults with dementia (n = 295) hospitalized at one of two teaching hospitals between 2015 and 2019 who were supported with mechanical ventilation (n = 191) or died without mechanical ventilation (n = 104). Multivariable logistic regression was used to examine associations between patient characteristics and mechanical ventilation use., Results: The median age was 78 years (IQR 71-86), 41% were female, 28% resided in a nursing home, and 58% had clinical markers of advanced dementia (dehydration, weight loss, mobility limitations, or pressure ulcers). Among patients supported with mechanical ventilation, 70% were intubated within 24 hours of presentation, including 31% intubated before hospital arrival. Younger age, higher illness acuity, and absence of a treatment-limiting Physician Orders for Life-Sustaining Treatment document were associated with mechanical ventilation use; nursing home residence and clinical markers of advanced dementia were not. Most patients (89%) had a documented goals of care discussion (GOCD) during hospitalization., Conclusion: Future efforts to promote goal-concordant care surrounding mechanical ventilation use for people living with dementia should involve identifying barriers to goal-concordant care in pre-hospital settings, assessing the timeliness of in-hospital GOCD, and developing strategies for in-the-moment crisis communication across settings., (Copyright © 2024 American Academy of Hospice and Palliative Medicine. Published by Elsevier Inc. All rights reserved.)

Background: Coronavirus disease 2019, caused by SARS-CoV-2 (SCV-2) was stated as a pandemic on March 11 2020 by World Health Organization (WHO), and since then, it has become a major health issue worldwide. It mainly attacks the respiratory system with various accompanying complications, including cardiac injury, renal failure, encephalitis and Stroke. Materials and Methods: The current systematic review has been compiled to summarize the available literature on SCV-2 induced ischemic Stroke and its subtypes. Further, the mechanisms by which the virus crosses the blood-brain barrier (BBB) to enter the brain have also been explored. The role of CRP and D-dimer as potent prognostic markers was also explored. The literature search was carried out comprehensively on Google scholar, PubMed, SCOP US, Embase and Cochrane databases by following guidelines. Results: All the studies were reviewed thoroughly by authors and disagreements were resolved by consensus and help of the senior authors. The most common subtype of the IS was found to be large artery atherosclerosis in SCV-2 induced IS. Hypertension emerged as the most significant risk factor. The mechanism resulting in elevated levels of CRP and D-dimer have also been discussed. However, there is a scarcity of definitive evidence on how SCV-2 enters the human brain. The available literature based on various studies demonstrated that SCV-2 enters through the nasopharyngeal tract via olfactory cells to olfactory neurons, astrocytes and via choroid plexus through endothelial cells. Further, disruption of gut-brain axis has been also discussed. Conclusion: Data available in the literature is not adequate to come to a conclusion. Therefore, there is a need to carry out further studies to delineate the possible association between SCV-2 induced IS.

MicroRNAs (miRNA) are a class of small non-coding RNA, roughly 21-22 nucleotides in length, which are master gene regulators. These miRNAs bind to the mRNA's 3' - untranslated region and regulate post-transcriptional gene regulation, thereby influencing various physiological and cellular processes. Another class of miRNAs known as mitochondrial miRNA (MitomiRs) has been found to either originate from the mitochondrial genome or be translocated directly into the mitochondria. Although the role of nuclear DNA encoded miRNA in the progression of various neurological diseases such as Parkinson's disease, Alzheimer's disease, Huntington's disease, etc. is well known, accumulating evidence suggests the possible role of deregulated mitomiRs in the progression of various neurodegenerative diseases with unknown mechanism. We have attempted to outline the current state of mitomiRs role in controlling mitochondrial gene expression and function through this review, paying particular attention to their contribution to neurological processes, their etiology, and their potential therapeutic use., Competing Interests: Declaration of Competing Interest The Authors declare no competing interest., (Copyright © 2023 Elsevier B.V. All rights reserved.)

Background: Severe coronavirus disease 2019 (COVID-19) is associated with systemic hyper-inflammation. An adaptive interaction between gut microbiota and host immune systems is important for intestinal homeostasis and systemic immune regulation. The association of gut microbial composition and functions with COVID-19 disease severity is sparse, especially in India. We analysed faecal microbial diversity and abundances in a cohort of Indian COVID-19 patients to identify key signatures in the gut microbial ecology in patients with severe COVID-19 disease as well as in response to different therapies. The composition of the gut microbiome was characterized using 16Sr RNA gene sequences of genomic DNA extracted from faecal samples of 52 COVID-19 patients. Metabolic pathways across the groups were predicted using PICRUSt2. All statistical analyses were done using Vegan in the R environment. Plasma cytokine abundance at recruitment was measured in a multiplex assay., Results: The gut microbiome composition of mild and severe patients was found to be significantly different. Immunomodulatory commensals, viz. Lachnospiraceae family members and Bifidobacteria producing butyrate and short-chain fatty acids (SCFAs), were under represented in patients with severe COVID-19, with an increased abundance of opportunistic pathogens like Eggerthella. The higher abundance of Lachnoclostridium in severe disease was reduced in response to convalescent plasma therapy. Specific microbial genera showed distinctive trends in enriched metabolic pathways, strong correlations with blood plasma cytokine levels, and associative link to disease outcomes., Conclusion: Our study indicates that, along with SARS-CoV-2, a dysbiotic gut microbial community may also play an important role in COVID-19 severity through modulation of host immune responses., (© 2023. The Author(s).)

Context: Goals-of-care discussions are important for patient-centered care among hospitalized patients with serious illness. However, there are little data on the occurrence, predictors, and timing of these discussions., Objectives: To examine the occurrence, predictors, and timing of electronic health record (EHR)-documented goals-of-care discussions for hospitalized patients., Methods: This retrospective cohort study used natural language processing (NLP) to examine EHR-documented goals-of-care discussions for adults with chronic life-limiting illness or age ≥80 hospitalized 2015-2019. The primary outcome was NLP-identified documentation of a goals-of-care discussion during the index hospitalization. We used multivariable logistic regression to evaluate associations with baseline characteristics., Results: Of 16,262 consecutive, eligible patients without missing data, 5,918 (36.4%) had a documented goals-of-care discussion during hospitalization; approximately 57% of these discussions occurred within 24 hours of admission. In multivariable analysis, documented goals-of-care discussions were more common for women (OR=1.26, 95%CI 1.18-1.36), older patients (OR=1.04 per year, 95%CI 1.03-1.04), and patients with more comorbidities (OR=1.11 per Deyo-Charlson point, 95%CI 1.10-1.13), cancer (OR=1.88, 95%CI 1.72-2.06), dementia (OR=2.60, 95%CI 2.29-2.94), higher acute illness severity (OR=1.12 per National Early Warning Score point, 95%CI 1.11-1.14), or prior advance care planning documents (OR=1.18, 95%CI 1.08-1.30). Documentation of these discussions was less common for racially or ethnically minoritized patients (OR=0.823, 95%CI 0.75-0.90)., Conclusion: Among hospitalized patients with serious illness, documented goals-of-care discussions identified by NLP were more common among patients with older age and increased burden of acute or chronic illness, and less common among racially or ethnically minoritized patients. This suggests important disparities in goals-of-care discussions., (Copyright © 2022 American Academy of Hospice and Palliative Medicine. Published by Elsevier Inc. All rights reserved.)