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1. 4D flow MRI in abdominal vessels: prospective comparison of k-t accelerated free breathing acquisition to standard respiratory navigator gated acquisition

Author

Octavia Bane, Daniel Stocker, Paul Kennedy, Stefanie J. Hectors, Emilie Bollache, Susanne Schnell, Thomas Schiano, Swan Thung, Aaron Fischman, Michael Markl, and Bachir Taouli

Subjects
Medicine, Science
Abstract

Abstract Volumetric phase-contrast magnetic resonance imaging with three-dimensional velocity encoding (4D flow MRI) has shown utility as a non-invasive tool to examine altered blood flow in chronic liver disease. Novel 4D flow MRI pulse sequences with spatio-temporal acceleration can mitigate the long acquisition times of standard 4D flow MRI, which are an impediment to clinical adoption. The purpose of our study was to demonstrate feasibility of a free-breathing, spatio-temporal (k−t) accelerated 4D flow MRI acquisition for flow quantification in abdominal vessels and to compare its image quality, flow quantification and inter-observer reproducibility with a standard respiratory navigator-gated 4D flow MRI acquisition. Ten prospectively enrolled patients (M/F: 7/3, mean age = 58y) with suspected portal hypertension underwent both 4D flow MRI acquisitions. The k−t accelerated acquisition was approximately three times faster (3:11 min ± 0:12 min/9:17 min ± 1:41 min, p

Published
2022
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2. Oxylipin metabolism is controlled by mitochondrial β-oxidation during bacterial inflammation

Author

Mariya Misheva, Konstantinos Kotzamanis, Luke C. Davies, Victoria J. Tyrrell, Patricia R. S. Rodrigues, Gloria A. Benavides, Christine Hinz, Robert C. Murphy, Paul Kennedy, Philip R. Taylor, Marcela Rosas, Simon A. Jones, James E. McLaren, Sumukh Deshpande, Robert Andrews, Nils Helge Schebb, Magdalena A. Czubala, Mark Gurney, Maceler Aldrovandi, Sven W. Meckelmann, Peter Ghazal, Victor Darley-Usmar, Daniel A. White, and Valerie B. O’Donnell

Subjects
Science
Abstract

Oxylipins are lipid mediators generated during infection for regulating inflammatory responses, but how they are removed is not completely clear. Here the authors show that cellular oxylipin removal is linked to mitochondria β-oxidation by CPT1, a mitochondria lipid importer protein, to serve as a metabolic checkpoint for oxylipin homeostasis and inflammation.

Published
2022
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3. Index

Author

Paul Kennedy

Published
2015

17. Contents

Author

Paul Kennedy

Published
2015

21. Relationship Between Severity of Ischemia and Coronary Artery Disease for Different Stress Test Modalities in the ISCHEMIA Trial

Author

Reynolds, Harmony R., Page, Courtney B., Shaw, Leslee J., Berman, Daniel S., Chaitman, Bernard R., Picard, Michael H., Kwong, Raymond Y., Min, James K., Leipsic, Jonathon, Mancini, G.B. John, Budoff, Matthew J., Hague, Cameron J., Senior, Roxy, Szwed, Hanna, Bhargava, Balram, Celutkiene, Jelena, Gadkari, Milind, Bainey, Kevin R., Doerr, Rolf, Ramos, Ruben B., Ong, Peter, Naik, Sudhir R., Steg, Philippe Gabriel, Goetschalckx, Kaatje, Chow, Benjamin J.W., Scherrer-Crosbie, Marielle, Phillips, Lawrence, Mark, Daniel B., Spertus, John A., Alexander, Karen P., O’Brien, Sean M., Boden, William E., Bangalore, Sripal, Stone, Gregg W., Maron, David J., Hochman, Judith S., Mavromatis, Kreton, Linefsky, Jason, Miller, Todd, Banerjee, Subhash, Newman, Jonathan D., Donnino, Robert M., Saric, Muhamed, Abdul-Nour, Khaled, Stone, Peter H., Jang, James J., Yee, Gennie, Weitz, Steven, Arnold, Suzanne, James Henry, O’Keefe, Jr, Shapiro, Michael D., Fein, Steven A., Torosoff, Mikhail T., Lyubarova, Radmila, Mookherjee, Sulagna, Drzymalski, Krzysztof, McFalls, Edward O., Garcia, Santiago A., Bertog, Stefan C., Siddiqui, Rizwan A., Ishani, Areef, Hansen, Ronnell A., Georges Khouri, Michel, Goldberg, Jonathan L., Goldweit, Richard, Cohen, Ronny A., Mirrer, Brooks, Navarro, Victor, Winchester, David E., Kronenberg, Marvin, McFarren, Christopher, Heitner, John F., Dauber, Ira M., Cannan, Charles, Sudarshan, Sriram, Mehta, Puja K., McDaniel, Michael, Lerakis, Stamatios, Quyyumi, Arshed, Wenger, Nanette K., Hedgepeth, Chester M., Hurlburt, Heather, Rosen, Alan, Sahul, Zakir, Leung, Steve, Reda, Hassan, Ziada, Khaled, Setty, Sampoornima, Barua, Rajat S., Hage, Fadi, Davies, James E., Leesar, Massoud, Heo, Jaekyeong, Iskandrian, Amy, Al Solaiman, Firas, Singh, Satinder, Dajani, Khaled, El-Hajjar, Mohammad, Der Mesropian, Paul, Sacco, Joseph, McCandless, Brian, Orgera, Marisa, Sidhu, Mandeep S., Arif, Imran, Kerr, Hanan, Trejo (Gutierrez), Jorge F., Fletcher, Gerald, Lane, Gary E., Neeson, Lynn M., Parikh, Pragnesh P., Pollak, Peter M., Shapiro, Brian P., Landolfo, Kevin, Gemignani, Anthony, OʼRourke, Daniel, Meadows, Judith L., Call, Jason T., Hannan, Joseph, Bojar, Robert, Kumar, Deepti, Mukai, John, Martin, Edward T., Vorobiof, Gabriel, Moorman, Alec, Kinlay, Scott, Hamburger, Robert J., Rocco, Thomas P., Bhatt, Deepak L., Croce, Kevin, Quin, Jacquelyn A., Anumpa, Jati, Zenati, Marco, Faxon, David P., Rayos, Glenn, Seedhom, Ashraf, Sullenberger, Lance, Kumkumian, Gregory, Sedlis, Steven P., Donnino, Robert M., Lorin, Jeffrey, Tamis-Holland, Jacqueline E., Kornberg, Robert, Leber, Robert, Saba, Souheil, Lee, Michael W., Small, Delano R., Nona, Wassim, Alexander, Patrick B., Rehman, Iram, Badami, Umesh, Marzo, Kevin, Robbins, Inga H., Levite, Howard A., Shetty, Sanjay, Patel, Mayuri, Hamroff, Glenn S., Little, Raymond W., Zimbelman, Brandi D., Lui, Charles Y., Smith, Brigham R., Vezina, Daniel P., Khor, Lillian L., Abraham, Josephine D., Bull, David A., McKellar, Stephen H., Booth, David, Kotter, John, Abdel-Latif, Ahmed, Hu, Bob, Labovitz, Arthur J., Berlowitz, Michael, Rogal, Philip, Matar, Fadi, Caldeira, Christiano, Rodriguez, Fatima, Schnittger, Ingela, Fearon, William F., Deedwania, Prakash, Reddy, Kiran, Sweeny, Joseph, Spizzieri, Christopher, Hochberg, Claudia P., Salerno, William D., Wyman, Ray, Zarka, Amer, Shah, Anil V., Haldis, Thomas, Kohn, Jeffrey A., Girotra, Saket, Almousalli, Omar, Krishnam, Mayil S., Milliken, Jeffrey C., Patel, Pranav M., Seto, Arnold H., Harley, Kevin T., Gibson, Michael A., Allen, Byron J., Coram, Rita, Thomas, Sabu, Schwartz, Ronald G., Chen, Wei, El Shahawy, Mahfouz, Stafford, James, Abernethy, William B., Zurick, Andrew, Meyer, Thomas M., Morford, Ronald G., Rutkin, Bruce, Bokhari, Sabahat, Sokol, Seth I., Meisner, Jay, Hamzeh, Ihab, Misra, Arunima, Matthew, Wall, Jr, De Rosen, Veronica Lenges, Alam, Mahboob, Turner, Michael C., Mulhearn, Thomas J., Good, Arnold P., Shammas, Nicolas W., Chilton, Robert, Nguyen, Patricia K., Jezior, Matthew, Gordon, Paul C., Crain, Thomas, Stenberg, Robert, Pedalino, Ronald P., Wiesel, Joseph, Juang, George J., Al-Amoodi, Mohammed, Wohns, David, Lader, Ellis W., Mumma, Michael, Dharmarajan, Lekshmi, Joseph F.X., McGarvey, Jr, Downes, Thomas R., Luckasen, Gary J., Cheong, Benjamin, Potluri, Srinivasa, Mastouri, Ronald A., Breall, Jeffery A., Revtyak, George E., Bazeley, Jonathan W., Li, Dayuan, Giedd, Kenneth, Old, Wayne, Burt, Francis, Sokhon, Kozhaya, Gopal, Deepika, Valeti, Uma S., Kobashigawa, Jon, Chakanalil Govindan, Sajeev, Gopalan Nair, Rajesh, Nanjappa Manjunath, Cholenahally, Moorthy, Nagaraja, Cholenahally Manjunath, Satvic, Narayanappa, Suryaprakash, Pandit, Neeraj, Kumar Nath, Ranjit, Dwivedi, S.K., Narain, V.S., Chandra, Sharad, Wander, Gurpreet S., Tandon, Rohit, Ralhan, Sarju, Aslam, Naved, Goyal, Abhishek, Karthikeyan, G., Ramakrishnan, S., Seth, Sandeep, Yadav, Rakesh, Singh, Sandeep, Roy, Ambuj, Parakh, Neeraj, Kumar Verma, Sunil, Narang, Rajiv, Mishra, Sundeep, Naik, Nitish, Sharma, Gautam, Kumar Choudhary, Shiv, Patel, Chetan, Gulati, Gurpreet, Sharma, Sanjeev, Bahl, V.K., Mathew, Anoop, Punnoose, Eapen, Gadage, Siddharth, Umesh Pillay, Tapan, Satheesh, Santhosh, Mathur, Atul, Christopher, Johann, Menon, Rajeev, Kumar, Nirmal, Oomman, Abraham, Mao, Robert, Solomon, Hilda, Parveen Khan, Sajeeda, Grant, Purvez, Kachru, Ranjan, VK, Ajit Kumar, Ganapathi, Sanjay, K., Jayakumar, Sivadasanpillai, Harikrishnan, Sasidharan, Bijulal, T.R., Kapilamoorthy, Polamuri, Praneeth, Kaul, Upendra, Fox, Keith A.A., Carruthers, Kathryn, Elghamaz, Ahmed, Gurunathan, Sothinathan, Karogiannis, Nikolaos, Shah, Benoy N., Trimlett, Richard H.J., Rubens, Michael B., Nicol, Edward D., Mittal, Tarun K., Hampson, Reinette, Andreas Gamma, Reto, de Belder, Mark A., Thambyrajah, Jeet, Nageh, Thuraia, Davies, John R., Lindsay, Steven J., Kurian, John, Jamil, Haqeel, Raheem, Osama, Hoye, Angela, Donnelly, Patrick, Valec ka, Bernardas, Chauhan, Anoop, Barr, Craig, Alfakih, Khaled, Byrne, Jonathan, Webb, Ian, Henriksen, Peter, O. Kane, Peter, de Silva, Ramesh, Conway, Dwayne S.G., Sirker, Alexander A., Hoole, Stephen P., Witherow, Fraser N., Johnston, Nicola, Harbinson, Mark, Walsh, Simon, Douglas, Hanna, Luckie, Matthew, Sobolewska, Jolanta, Jeetley, Paramjit, Patel, Niket, Kotecha, Tushar, Travill, Christopher, Karimullah, Iqbal, Al-Bustami, Mahmud, Braganza, Denise, Henderson, Robert, Pointon, Kate, Naik, Surendra, Mathew, Thomas, Berry, Colin, Collison, Damien, Roditi, Giles, Moriarty, Andrew J., Glover, Jason D., Pradhan, Jiwan, Ghada, Mikhail, Francis, Darrel P., Dzavik, Vladimir, Diaz, Ariel, Rheault, Philippe, Barrero, Miguel, Gagné, Carl-Éric, Pépin-Dubois, Yanek, Costa, Ricardo, Tung Sia, Ying, Lemay, Catherine, Gisbert, Alejandro, Gervais, Pierre, Rheault, Alain, Carl Phaneuf, Denis, Gosselin, Gilbert, Garg, Pallav, Hessian, Renee C., Beanlands, Rob S., Davies, Richard F., Cheema, Asim N., Bagai, Akshay, Wald, Ron, Goodman, Shaun, Graham, John Joseph, Peterson, Mark, Chow, Chi-Ming, Abramson, Beth, Nazir Cheema, Asim, Tariq Vakani, Mohammad, Cha, James, Howarth, Andrew G., Wong, Graham, Uxa, Amar, Galiwango, Paul, Kassam, Saleem, Mukherjee, Ashok, Joseph Ricci, A., Lam, Andy, Me, Shamir, Udell, Jacob, Généreux, Philippe, Hameed, Adnan, Daba, Ledjalem, Hueb, Whady, Cury Rezende, Paulo, Ciappina Hueb, Alexandre, Emanuela, Paola, Smanio, Poggio, Schaan de Quadros, Alexandre, Abdala, Renato, Kalil, Karam, da Costa Vieira, José Luiz, Grossmann, Gabriel, Píccaro de Oliveira, Pedro, Bridi, Leonardo, Savaris, Simone, Vitola, João V., Cerci, Rodrigo J., Farias, Fabio R., Fernandes, Miguel M., Antonio Marin-Neto, José, Schmidt, André, de Oliveira Lima Filho, Moysés, Mendes Oliveira, Ricardo, Reynaldo, João, Chierice, Abbud, Polanczyk, Carísi A., Furtado, Mariana V., Smidt, Luis F., Carlos Carvalho, Antonio, Pucci, Gustavo, Lyra, Flavio, Rabelo, Alvaro, Junior, Alves, Dracoulakis, Marianna D.A., Lima, Rodolfo G.S.D., Figueiredo, Estevao, Ricardo Caramori, Paulo, Tumelero, Rogerio, Dall’Orto, Frederico, Mesquita, Claudio T., Colafranseschi, Alexandre S., Amarino C., Oliveira, Jr, Carvalho, Luiz A., Palazzo, Isabella C., Sousa, Andre S., da Silva, Expedito Eustáquio Ribeiro, Gabriel, Pedro, de Barros e Silva, Melo, de Pádua Silva Baptista, Luciana, Jamus Rodrigues, Marcelo, de Resende, Marcos Valério Coimbra, Francisco Saraiva, Jose, Costantini, Costantino, Ruzyllo, Witold, Demkow, Marcin, Pracon, Radoslaw, Kepka, Cezary, Teresinska, Anna, Kryczka, Karolina, Henzel, Jan, Solecki, Mateusz, Kaczmarska, Edyta, Mazurek, Tomasz, Drozdz, Jaroslaw, Czarniak, Bartosz, Frach, Malgorzata, Szymczyk, Konrad, Niedzwiecka, Iwona, Sobczak, Sebastian, Ciurus, Tomasz, Jakubowski, Piotr, Misztal-Teodorczyk, Magdalena, Teodorczyk, Dawid, Fratczak, Aleksandra, Szkopiak, Marcin, Lebioda, Patrycja, Wlodarczyk, Michal, Plachcinska, Anna, Kusmierek, Jacek, Miller, Magdalena, Marciniak, Halina, Wojtczak-Soska, Karolina, Łuczak, Katarzyna, Tarchalski, Tomasz, Cichocka-Radwan, Anna, Anna Szulczyk, Grazyna, Witkowski, Adam, Kukuła, Krzysztof, Celińska-Spodar, Małgorzta, Zalewska, Joanna, Gajos, Grzegorz, Bury, Krzysztof, Pruszczyk, Piotr, Roik, Marek, Łoboz-Grudzień, Krystyna, Sokalski, Leszek, Brzezińska, Barbara, Lesiak, Maciej, Łanocha, Magdalena, Reczuch, Krzysztof W., Kalarus, Zbigniew, Swiatkowski, Andrzej, Szulik, Mariola, Musial, Wlodzimierz J., Bockeria, Leo, Petrosyan, Karen, Trifonova, Tatiana, Chernyavskiy, Alexander M., Kretov, Evgeniy I., Grazhdankin, Igor O., Bershtein, Leonid L., Sayganov, Sergey A., Kuzmina-Krutetskaya, Anastasia M., Zbyshevskaya, Elizaveta V., Katamadze, Nana O., Demchenko, Elena A., Kozlov, Pavel S., Kozulin, Vikentiy Y., Lubinskaya, Ekaterina I., Lopez-Sendon, Jose, Castro, Almudena, Refoyo Salicio, Elena, Guzman, Gabriela, Galeote, Gabriel, Valbuena, Silvia, Peteiro, Jesús, Dolores Martínez-Ruíz, María, Pérez-Fernández, Ruth, Cuenca-Castillo, José J., Flores-Ríos, Xacobe, Prada-Delgado, Óscar, Barge-Caballero, Gonzalo, Ramon Gonzalez Juanatey, Jose, Souto Bayarri, Miguel, Pubull Nuñez, Virginia, Ocaranza Sanchez, Raymundo, Cid Alvarez, Belen, Peña Gil, Carlos, Martinez Monzonis, Amparo, Sionis, Alessandro, Vila Perales, Montserrat, Maria Padró, Josep, Serra Peñaranda, Antonio, García Picart, Joan, Ginel Iglesias, Antonino, Garcia-Moll Marimon, Xavier, Pons Lladó, Guillem, Carreras Costa, Francesc, Miro, Vicente, Diez, Jose L., Calvillo, Pilar, Marin Ortuño, F., Valdés Chávarri, M., Tello Montolliu, A., Pinar Bermudez, E., De La Morena, G., Gracida Blancas, Montserrat, Enrique Castillo Luena, Jose, Fernandez-Aviles, Francisco, Chen, Jiyan, Wu, Yongjian, Ma, Yitong, Yang, Yining, Ji, Zheng, Yang, Xinchun, Lin, Wenhua, Zeng, Hesong, Fu, Xin, Wang, Songtao, Cheng, Gong, Zhao, Yulan, Fang, Xuehua, Zeng, Qiutang, Su, Xi, Li, Qingxian, Nie, Shao-Ping, Yu, Qin, Wang, Jianʼan, Zhang, Shuyang, Liu, Zhenyu, Maggioni, Aldo P., Piero Perna, Gian, Marini, Marco, Gabrielli, Gabriele, Provasoli, Stefano, Verna, Edoardo, Monti, Lorenzo, Nardi, Barbara, Di Chiara, Antonio, Mortara, Andrea, Galvani, Marcello, Ottani, Filippo, Sicuro, Marco, Calabro, Paolo, Formisano, Tiziana, Tarantini, Giuseppe, Cucchini, Umberto, Luigi Andres, Anto, Racca, Emanuela, Briguori, Carlo, Amati, Roberto, Vergoni, William, Russo, Aldo, Fanelli, Raffaele, Poh, Kian-Keong, Chai, Ping, Lau, Titus, Loh, Joshua P., Tay, Edgar L., Teoh, Kristine, Teo, Lynette L., Ong, Ching-Ching, Wong, Raymond C., Loh, Poay-Huan, Kofidis, Theodoros, Xian Chan, Wan, Hui Chan, Koo, Foo, David, Loh Kwok Kong, Jason, Ching, Min, Er, Haider Jafary, Fahim, Chua, Terrance, Stumpf, Juergen, Matschke, Klaus, Simonis, Gregor, Kadalie, Clemens T., Sechtem, Udo, Christian Schulze, P., Goebel, Bjoern, Lenk, Karsten, Nickenig, Georg, Schuchlenz, Herwig, Weikl, Stefan, Marthe Lang, Kurt Huber, Irene, Jakl-Kotauschek, Gabriele, Vertes, Matyas Keltai Andras, Varga, Albert, Fontos, Geza, Merkely, Bela, Kerecsen, Gabor, Hinic, Sasa, Zdravkovic, Marija, Mudrenovic, Vladan, Crnokrak, Bogdan, Beleslin, Branko D., Boskovic, Nikola N., Petrovic, Marija T., Dobric, Milan R., Markovic, Zeljko Z., Mladenovic, Ana S., Cemerlic-Adjic, Nada, Davidović, Goran, Vučić, Rada, Nikola Dekleva, Milica, Stankovic, Goran, Apostolovic, Svetlana, Escobedo, Jorge, Baleón-Espinosa, Rubén, Campos-Santaolalla, Arturo S., Durán-Cortés, Elihú, Flores-Palacios, José M., García-Rincón, Andrés, Jiménez-Santos, Moisés, Peñafiel, Joaquín V., Ortega-Ramírez, José A., Valdespino-Estrada, Aquiles, Alexánderson Rosas, Erick, Murphy, Deirdre, Selvanayagam, Joseph B., Joseph, Majo X., Thambar, Suku T., Rankin, Jamie, Beltrame, John F., Hillis, Graham S., Thuaire, Christophe, Dutoiu, Téodora, Juliard, Jean-Michel, Slama, Michel S., El Mahmoud, Rami, Nicollet, Eric, Goube, Pascal, Barone-Rochette, Gilles, Furber, Alain, Bière, Loïc, Laucevicius, Elvin Kedhi, Aleksandras, Timmer, MD Jorik, Hermanides, Rik, Kaplan, Eliza, Riezebos, Robert K., Samadi, Pouneh, van Dongen, Elise, Niehe, Sander R., Suryapranata, Harry, van Vugt, Stijn, Cacela, Duarte, Santana, Ana, Fiarresga, Antonio, Sousa, Lidia, Marques, Hugo, Patricio, Lino, Bernanrdes, Luis, Rio, Pedro, Carvalho, Ramiro, Ferreira, Rui, Silva, Tiago, Rodrigues, Ines, Modas, Pedro, Portugal, Guilherme, Fragata, Jose, Pinto, Fausto J., Nobre Menezes, Miguel, Cantinho Lopes, Guilhermina, Gomes Almeida, Ana, Canas Silva, Pedro, Nobre, Angelo, Rita Francisco, Ana, Ferreira, Nuno, Lopes, Ricardo L., Diaz, Rafael, Guzman, Luis, César Figal, Julio, Méndiz, Oscar, Cortés, Claudia, René Favaloro, Roberto, Alvarez, Carlos, Courtis, Javier, Zeballos, Gabriela, Schiavi, Lilia, Rubio, Mariano, Alsweiler, Caroline, Patrick Devlin, Gerard, Fisher, Raewyn, Alan Huston Stewart, Ralph, Douglas White, Harvey, Benatar, Jocelyne, Kedev, Sasko, Peovska Mitevska, Irena, Srbinovska Kostovska, Elizabeta, Pejkov, Hristo, Held, Claes, Eggers, Kai, Frostfelt, Gunnar, Johnston, Nina, Olsowka, Maciej, Åkerblom, Axel, Soveri, Inga, Aspberg, Johannes, Beyar, Rafael, Nikolsky, Eugenia, Sharir, Tali, Elian, Dan, Kerner, Arthur, Massalha, Samia, Fukuda, Keiichi, Kohsaka, Shun, Yasuda, Satoshi, Nishimura, Shigeyuki, Van de Werf, Frans, Claes, Kathleen, Hung, Chung-Lieh, Yun, Chun-Ho, Jia-Yin Hou, Charles, Kuo, Jen-Yuan, Yeh, Hung-I, Hung, Ta-Chuan, Li, Jiun-Yi, Chien, Chen-Yen, Tsai, Cheng-Ting, Liu, Chun-Chieh, Yu, Fa-Chang, Lin, Yueh-Hung, Lan, Wei-Ren, Yen, Chih-Hsuan, Tsai, Jui-Peng, Sung, Kuo-Tzu, Ntsekhe, Mpiko, Pandie, Shaheen, Viljoen, Charle A., De Andrade, Marianne, Moccetti, Tiziano, Grazia Rossi, M., Abdelhamid, Magdy, Adel, Ahmed, Kamal, Ahmed, Mahrous, Hossam, El Kaffas, Sameh, El Fishawy, Hussien, Pop, Calin, Claudia, Matei, Popescu, Bogdan A., Ginghina, Carmen, Deleanu, Dan, Iliescu, Vlad A., Al-Mallah, Mouaz H., Aljzeeri, Ahmed, Najm, Hani, Alghamdi, Ali, Ramos, Walter Enrique Mogrovejo, Kuanprasert, Srun, Prommintikul, Arintaya, Nawarawong, Weerachai, Woragidpoonpol, Surin, Tepsuwan, Thitipong, Taksaudom, Noppon, Rimsukcharoenchai, Chataroon, Euathrongchit, Juntima, Wannasopha, Yutthaphan, Yamwong, Sukit, Sritara, Piyamitr, Aramcharoen, Suthara, Meemuk, Krissada, Khairuddin, Ahmad, Abd Hadi, Hafidz, Azmi Yahaya, Shaiful, Doan, John, Lee, Raven, Patel, Risha, Yang Cho, So, Milbrandt, Susan, Shelstad, Dawn, Kamath, Preeti, Tejani, Ishita, Quiles, Kirsten J., Schley, Allison, Golden, Heather, Osseni, Hermine, Wiyarand, Charlene, Douglass, Peter, Pomeroy, Hayley, Craft, Alexandra, Harvey, Bethany, Anaya, Olivia, Goold, Phoebe, Giovannone, Steven, Pritchard, Lori, Gans Paul Kennedy, Rosann, Ganesan, Shobana, Schlichting, David, Naher, Aynun, Stewart, Wendy L., Salmi, Kristin M., Johnson, Debra K., Herrmann, Rebekah R., Arges, Kristine, LeFevre, Melissa, Tomfohr, Jennifer, Ann Byrne, Kimberly, Zappernick, Taissa, Canada, Sallie, Kakade, Meghana, Mieses, Patricia, Cobos, Stanley E., Dwyer, Raven R., Espinosa, Dalisa, Quiles, Kirsten J., Rantinella, Magdalena, Rodriguez, Jessica, Mancilla, Olivia, Stinson, Susan, Weyand, Terry, Crook, Sherron C., Ho, Jean, Khan, Saadat, Mohamed, Mahmoud, Soltau, Mary R., Rose, Delsa K., Wimmer, Rebecca J., Desire, Sukie, Rashid, Fauzia, Asier, Senait, Patel, Keyur, Gillis, Jennifer, Manocchia, Megan, Moore, Susan, Congdon, Elizabeth, Brandt, Gail, Marchelletta, Nora, Wippler, Kristina, Halverson, Kimberly E., Roraff, Christine, Thorsen, Jonean, Ojajuni, Amarachi, Olurinde, Oni, Surineni, Kamalakar, Valaiyapathi, Badhma, Kartje, Carol M., Rawlins, Michele, Thomson, Jennifer, Colleen Rogge, Mary, Bunke, Julie, Unterbrink, Kendra, Fannon, Jacqueline, Burman, Cynthia, Dubin, Marcia F., Beaudry, Sarah, Tirado, Stephanie A., Halliday, Janet, Julian, Stephanie, Pamela, Stanford M. Lane, Jennifer L., Arsenault, Patricia, Sigel, Pamela, Brooks, Miriam, Douangvila, Ladda, Gevorgyan, Rubine, Ranjbaran, Fatima, Smith, Bryn, Ohmart, Carly, Ly, Samantha, Quinn, Margot C., Temiyasathit, Sara, Do, Jacquelyn, Tobin, Desiree, Langdon, Jennifer, Werner Bayer, Marcia, OʼMalley, Amanda, Orvis, Erin, Murphy, Mandy, Greenberg, Ann, Iraola, Margaret, Maranan, Leandro C., Malinay, Ammy, Edillo, Candice P., Ostrander, Ann, Wasmiller, Stephanie, Drewes, Wendy, Patel, Dipti, White, Jackie M., Hallam, Alison, Spooner, Benjamin J., Hollenweger, Linda M., Little, Holly, Little, Tiffany, Eskelson, Nona A., Taul, Yvonne, Rodgers, Caroline, Isaacs, Jennifer, Bulkley, Viktoria, Kaneshiro, Renee, Kirby, Bonnie J., Tran, Nhi N., Jahrsdorfer, Catherine, Yunis, Reem, Patro, Jhina, Vega, Antonia, Bloise-Adames, Hugo, Jimenez, Santa, Saint Vrestil, Nicole, Bhandari, Reyna, Schade, Danielle, Yost, Roxanne, Beardsley, Paula, Fine, Denise, Tancredi, Jana, Arakelian, Patricia, Mathus, Susan, OʼNeill, Deborah, Burkhardt, Joy, Hosino, Suellen, Lubyanaya, Oksana A., Salas, Jose D., Aguirre, Maria, Dhawan, Manu, Parra, Diana, Tran, Tri, Fowler-Lehman, Katie, Spitzer, Natalie, Riedberger, Casey, Weick, Catherine, Quiles, Kirsten J., Drum, Carrie, Miller-Cox, Kimberly, Ollinger, Amy, Capasso-Gulve, Elizabeth, Melanie Loehr, Alaine, Mosley, Marlowe, Heydari, Shirin, Lundeen, Andrea M., Karanjah, Edgar, Marfori, Wanda C., Hernandez-Rangel, Eduardo, Singh, Pam, Marie Webb, Anne, Fridell, Ellie, Wilson, Heidi, Kim, Angela, Wilmot, Patrick, Stevens, Ramona, Black, Loriane, Hull, Amber B., Lim, Olivia J., Tucker, Helen C., Putnam, Natasha C., Hall, Linda L., Cauthren, Tia, Tucker, Trish, Horton, Hollie, Orga, Jan, White, Joyce R., Baumann, Cynthia, Seeratan, Vidya, Jimenez, Magnolia, Schultz, Cidney, Russo, Jeanne, Huda, Zohra, Boan, Araceli, Hinton, Christine R., Archer, Beth A., Dionne, Julia S., Allardyce, Cheryl A., Sikora, Lindsey N., Czerniak, Jennifer H., Mull, Jennifer A., Ferguson, Elizabeth, Laube, Frances, Shammas, Gail A., Christensen, Lori, Park, Holly, Hecht, Joan, Vo, Davis, Hirsch, James, Bindeman, Jody, Salkind, Sara, Desimone, Lori-Ann, Felix-Stern, Lina, Gomes, Jassira, Gordon, Catherine, Mann, Aimee, McCreary, Theresa, Quiles, Kirsten J., Gopaul, Candace, Hultberg, Karen, Huk, Tauqir, Hussain, Afshan, Zambrano, Yesenia, Medina Rodriguez, Sarah, Milner, Trudie, Mulder, Abbey, Van Oosterhout, Stacie, Meyer, Martha, Clapp, Nancy L., Barrentine, Heather, Jose, Jenne M., Manchery, Jenne, McKinney, Vera, Schwarz, Linda, Kaczkowski, Scott M., Jaskowiak, Adam J., Klitch, Joel, Dees, Debra, Vasquez, Precilia, Hannemann, Elise L., Mae Foltz, Judy, DeRosa, Emily, Jorgenson, Beth, Riestenberg-Smith, Joyce, Bariciano, Rebecca, Waldron, Jessica, Mayon, Michelle, Ann Peichel, Gretchen, Starks, Brandy, Garcia, Lucilla, Thottam, Maria, Anand, Anjali, Raj, Janitha, Ravindran, Reshma, Rajalekshmi, VS, Nataraj, Nandita, Bajaj, Sheromani, Yadav, Vandana, Mishra, Girish, Tewari, Roma, Mishra, Meenakshi, Patel, Shivali, Singh, Suman, Kaur, Baljeet, Gupta, Sonika, Suvarna, Chandini, Mannekkattukudy Kurian, Binoy, Rupesh Karwa, Sheetal, Kolhe, Suvarna, Vindhya, R.J., Jain, Peeyush, Seth, Ashok, Singh Meharwal, Zile, Verma, Atul, Bhatia, Mona, Sachdeva, Ankush, Indira Devi, Thounaojam, Jungla, Nungshi, Manjula Rani, K., Sowjanya Reddy, M., Preethi, K., Sidh, Rinu R., Priya, Vamshi, Preethi, Kotiboinna, Hande, Shweta, Dubey, Abhishek, Rawat, Vineeth, Kavita, Chacko, CP Manas, Babu, Suresh, Reddy, Sowjanya, Rani, Manjula, Arambam, Priyadarshani, Singh, Bebek, Young, Grace M., Kinsey, Christopher, Kavalakkat, Raisa, Evans, Jo, Hassan, Ikraam, Williams, Sarah, Holland, Kim, Swan, Karen, Atkinson, Bev, Kunhunny, Swapna, Atkinson, Craig, Krannila, Carita, Vinod, Manitha, Chaytor, Lisa, Cox, Leanne, Morrow, Julie, Rowe, Kay, Kelly, Stephanie, Regan, Susan, Turnbull, Dawn, Fleming, Catherine, Ghosh, Arijit, Gratrix, Karen, Preston, Stephen, Cartwright, Anne, Knightonc, Abigail, Martin, Katherine, Flint, Laura, Harrison, James, Lakeman, Nicki, Ljubez, Anja, Wright, Judith, Exley, Donna, Andiapen, Mervyn, Richards, Amy J., Wong, Lisa, Munro, Melanie J., McEvoy, Michelle, Brown, Caroline, Charles, Thabitha, Kolakaluri, Laurel, Phillips, Hannah, Morby, Louise, Hallett, Karen, Corbett, Carolyn, Winstanley, Lynne, Smit, Angelique, Gent, Susan, Hussain, Nafisa, Haines, Fiona, Taaffe, Joanne, Burton, Jane, Colton, Maria, King, Rachel, Brown, Ammani, Docherty, Andrew, McCloy, Lisa, Robb, Kate, Paterson, Craig, Crawford, Wenda, Kelly, Joanne, McGregor, Lorraine, Mackin, Anne, Knight, Janet P., Bose, Tuhina, Proietti, Anna, Brousseau, Myriam, Corfias, Magalie, Blaise, Patricia, Harvey, Luc, Alarie, Patricia, Arcand, Linda, Roy, Isabelle, Montpetit, Estelle, Drouin, Katia, Bergeron, Christine, Shelley, Christine, Masson, Christine, Carr, Sandy, Bone, Catherine, Moga, Ermina, Kourzenkova, Janetta, Walter, Olga, Hogg, Norma, Welsh, Suzanne, Hussain, Mohammed, Bello, Olugbenga, Syed, Ishba, Kushniriuk, Khrystyna, Otis, Judy, Otis, Rebecca, Seib, Michelle M., Rivest, Sandra M., Sandonato, Rosa, Chow, Jackie, Starovoytov, Andrew, Uchida, Naomi, Meadows, Ngaire, Asif, Nadia, Tavares, Suzana, Bozek, Bev, Shier, Maria, Larmand, Lori-Ann, Janmohamed, Amir, Hart, Brenda, Marucci, Jane, Tai, Sharon, Brons, Sonya, Beck, Chris, Wong, Glenda, Etherington, Krystal, Arumairajah, Thippeekaa, Aprile, Maria, Karlsson, Sara, Webber, Susan, Mercure, Chantale, Aedy, Nancy, Farquharson, Fran, Siddiqui, Anam, Emy Takiuti, Myrthes, Pizzol Caetano, Leonardo, Peixoto Deiro, Aline, Manica Muller, Alice, de Moraes, Maria Antonieta Pereira, Maria Ascoli, Bruna, Zottis Poletti, Sílvia, Zier, Sandra S., Veiga, Vilmar, Franca da Cunha, Diego, Rucatti, Guilherme G., Igansi, Fernanda, Haeffner, Mauren P., Almeida, Viviane, Sanchez de Souza, Gabriela, Almeida, Mayana, dos Santos, Viviane, Oliveira, Natalia S., Edilena Paulino Azevedo, Bruna, Bizzaro Santos, Marco, Germann, Amanda, Gomes, Vitor, Homem, Rosa, Magedanz, Ellen, Laimer, Rosane, Tognon, Alexandre, Santos, Roberta P., Yumi Okada, Mariana, Paula Batista, Ana, Nogueira Rabaça, Aline, Miranda Trama, Larissa, Silva, Talita, de Souza Ormundo, Camila Thais, Vicente, Carla, Pinheiro, Caroline, Komar, Daniele, Walesiak, Olga, Malinowska, Katarzyna, Maksym, Jakub, Wojtera, Karolina, Fojt, Anna, Szczerba, Ewa, Swiderek, Marta, Wojtala, Ewelina, Karwowski, Jaroslaw, Łabyk, Andrzej, Szramowska, Agnieszka, Zdończyk, Olga, Jaroch, Joanna, Kolodziej, Adam, Marcinkiewicz-Siemion, Marta, Bockeria, Olga, Kudzoeva, Zalina, Aripova, Nodira, Naryshkin, Ivan A., Kuleshova, Alena, Malaev, Dastan, Subbotina, Irina, Gumerova, Victoria, Nikolaeva, Olga B., Fernández-Figares, Pharm, Virginia, Alonso-Álvarez, Moisés Blanco-Calvo Encarnación, García-González, Paula, Seijas Amigo, Jose, Fernández Martínez, Begoña Igual, Ana, Romero Aniorte, M. Quintana Giner A.I., Rivera Caravaca, J.M., Cañavate, Olga, Guerrero, Sonia, Riera, Silvia, Lasala, Maria, Lorenzo, Maria, Sobrino, Olga, Vazquez, Alexandra, Dong, Haojian, He, Peiyu, Xia, Chunli, Yang, Junqing, Zhong, Qi, Tian, Yanmeng, Li, Dongze, Li, Xiaomei, Ma, Xiang, Yu, Zixiang, Zhao, Qian, Li, Chunguang, Zhang, Lei, Zhao, Yu, Zhu, Bolin, Chen, Mulei, Chi, Hongjie, Wang, Yang, Zhang, Jing, Jing, Rui, Liu, Jingjing, Zhou, Qiang, Xu, Chang, Li, Zhuxi, Li, Junhua, Xiong, Luyang, Gao, Dan, Jiang, Dengke, Leng, Ran, Wang, Xutong, Yuan, Qianqian, Zhang, Lili, Bai, Ziliang, Li, Jianhua, Qi, Jie, Wang, Fei, Wang, Haitao, Yang, Bin, Yue, Zhou, Zhang, Zhulin, Dong, Yumei, Mao, Jiajia, Zhang, Bin, Li, Xiuhong, Yao, Xiaowei, Zhong, Nier, Zhou, Ning, Huang, Yaping, Zhou, Wei, Panpan, Peng, Yu Kunwu Yudong, Su, Xin, Wang, Chen, Zhao, Yunhai, Geng, Yaming, Wang, Yanfu, Fan, Jing-Yao, Feng, Si-Ting, Wang, Xiao, Yan, Yan, Zhang, Hui-Min, Chi, Lingping, Liu, Fang, Chen, Han, Jiang, Jun, Li, Huajun, Han, Yechen, Xu, Lihong, Chen, Gang, Hu, Rongrong, Pietrucci, Francesca, Di Donato, Anna, Pezzetta, Francesca, Casali, Valentina, Attanasio, Chiara, Leone, Gianpiero, Pisano, Francesco, Bare, Cristina, Fimiani, Fabio, Barioli, Alberto, Ramani, Federica, Rolfo, Fabrizio, Goletto, Cecilia, De Micco, Francesca, Di Marco, Stefano, Tricoli, Martina, Villella, Massimo, Tan, Sik-Yin V., Sia, Winnie C., Leong, Audrey W., Hai Yan, Li, Ismail, Nasrul, Tun Kyaw, Min, Yip, Deborah, Grahl, Dorit, Guenther, Franziska, Bonin, Kerstin, Wenzelburger, Ina, Gruensfelder, Susanne, Sinning, Jan-Malte, Weber, Marcel, Werner, Nikos, Steinmaurer, Gudrun, Winter, Tijana, Andric, Max-Paul, Tscharre, Claudia, Maximilian, Bernhard, Jäger, Wegmayrc, Egger, Floria, Davidovits, Judit Sebo Zoltan, Matics, Laszlone, Ágoston, Gergely, Dekany, Gabor, Bartykowszki, Andrea, Jakal, Agnes, Djokic, Jelena, Djordjevic-Dikic, Ana D., Giga, Vojislav L., Stepanovic, Jelena J., Velicki, Lazar, Pupic, Ljiljana, Simović, Stefan M., Stevo Martinovic, Miroslav, Stevanovic, Gordana, Dobric, Milan, Salinger Martinovic, Sonja, Stanojevic, Dragana, de Jesús-Pérez, Ramon, Brassetti, María Fernanda Canales, Adrián Vences Anaya, Diego, Pérez García, María, Estela Carvajal Juarez, Isabel, Madero Rovalo, Magdalena, Lee, Sau, Thomas, Prince, Chaplin, Melissa D., Stansborough, Jeanette K., Black, Marilyn, Bonner, Michelle M., Ireland, Kim F., Venn-Edmonds, Clare, Thobois, Corine, Tachot, Emilie, Laure, Christophe, Vassaliere, Christel, Abergel, Helene, Fuentes, Axelle, Eliahou, Ludivine, Dubourg, Olivier, Michaud, Pierre, Hadjih, Sarah, Brito, Patricia, Cornet, Charles, Rautureau, Jeremy, Juceviciene, Agne, Kalibataite-Rutkauskiene, Irma, Keinaite, Laura, Laukyte, Monika, Mikolaitiene, Gelmina, Smigelskaite, Akvile, Tamasauskiene, Ilona, Urboniene, Agne, Bouwhuis, Ilse, Nijmeijer, Jeannette, Lia, Elisabeth, J.M. Schoep, Ahoud, M. Janzen Sandra, Selas, Mafalda, Silva, Filipa, Freixo, Cláudia, Zimbarra Cabrita, Inês, Rocha, Andreia, Patuleia Figueiras, Francisca, Coelho, Andreia, Capinha, Marta, Inês Caetano, Maria, Silva, Susana, Tinnirello, Veronica, Nicolás Mungo, Matías, Garcia, Marina, Godoy, Valeria, Victoria Actis, Maria, Scaro, Graciela, Low, Liz, Scales, Jayne, Abercrombie, Kirsty, Howell, Leah, Patten, Cathrine, Björklund, Christina, Andreasson, Maria, Essermark, Marie, Persson, Liselotte, Harel, Or, Bentzvi, Margalit, Helmer, Ludmila, Ueda, Ikuko, Fujita, Jun, Furukawa, Akemi, Hirase, Kanae, Nagai, Toshiyuki, Otsuka, Fumiyuki, Nakano, Shintaro, Robesyn, Valerie, Yang, Yi-Hsuan, Mtana, Noloyiso, Anesini, Adriana, Maspoli, Simona, Mombelli, Manuela, Talaat, Ahmed, Rosca, Monica, Beladan, Carmen C., Zahrani, Sarah, Antonio Monsalve Davila, Marco, Khwakhong, Supatchara, Chaiyasri, Anong, Mekara, Warangkana, Kulthawong, Supap, Amaritakomol, Anong, Panpunuan, Pachara, Syamira Mokhtar, Noor, Asiah Basri, Nor, Yusnida, Irni, Hashim, Humayrah, Berger, Jeffrey, Williams, David, Harrington, Robert, Jiang, Lixin, Lopes, Renato D., Noel Bairey Merz, C., Weintraub, William, Donato Morales Rodríguez, Erick, Maurovich-Horvat, Pal, Sonawane, Poonam, Francis, Ramakrishnan, Rajesh, Nayak, T. Soundarya, Boer, Stephanie C., Rosenberg, Yves, Hamm, Christian, Helm, Malte, Peterson, Eric, Ballantyne, Christie, Calfas, Karen, Ann Champagne, Mary, Fleg, Jerome, McCullough, Peter A., Menasche, Philippe, Davidson, Michael, Fremes, Stephen, Guyton, Robert, Mack, Michael, Mohr, Fred, Rao, Anupama, Sabik, Joe, Shapira, Oz, Taggart, David, Tatoulis, James, Blankenship, Jim, Brener, Sorin, Buller, Chris, Colombo, Antonio, de Bruyne, Bernard, Kereiakes, Dean, Lefevre, Thierry, Moses, Jeffrey, Mahaffey, Ken, Cruz-Flores, Salvador, Danchin, Nicholas, Feen, Eli, Garcia, Mario J., Hauptman, Paul, Laddu, Abhay A., Passamani, Eugene, Pina, Ileana L., Simoons, Maarten, Skali, Hicham, Thygesen, Kristian, Waters, David, Endsley, Patricia, Esposito, Gerard, Kanters, Jeffrey, Pownall, John, Stournaras, Dimitrios, Friedrich, Matthias, Hachamovitch, Rory, Oliver, Dana, Harrel, Frank, Blume, Jeffrey, Lee, Kerry, Kullo, Iftikhar, McManus, Bruce, Newby, Kristin, Cohen, David, Bugiardini, Raffaele, Mattina, Deirdre, Ali, Ziad, Mathew, Roy, Friedman, Lawrence, Anderson, Jeffrey, Berg, Jessica, DeMets, David, Michael Gibson, C., Lamas, Gervasio, Deming, Nicole, Himmelfarb, Jonathan, Ouyang, Pamela, Woodard, Pamela, Nwosu, Samuel, Kirby, Ruth, Jeffries, Neal, Denaro, Jean E., Boumakis, Stephanie, Chan, Kevin, Cobb, Gia, Contreras, Aira, Cukali, Diana, Ferket, Stephanie, Gabriel, Andre, Hansen, Antonietta, Roberts, Arline, Chang, Michelle, Islam, Sharder, Wayser, Graceanne, Yakubov, Solomon, Yee, Michelle, Callison, Caroline, Hogan, Isabelle, Qelaj, Albertina, Pirro, Charlotte, Van Loo, Kerrie, Wisniewski, Brianna, Gilsenan, Margaret, Lang, Bevin, Mohamed, Samaa, Esquenazi-Karonika, Shari, Mathews, Patenne D., Naumova, Anna, Lyo, Jihyun, Setang, Vincent, Xavier, Mark, Anstrom, Kevin, Baloch, Khaula, Blount, Janet, Cowper, Patricia, Davidson-Ray, Linda, Drew, Laura, Harding, Tina, David Knight, J., Minshall Liu, Diane, O’Neal, Betsy, Redick, Thomas, Jones, Philip, Nugent, Karen, Jingyan Wang, Grace, Goyal, Abhinav, Hetrick, Holly, Hayes, Sean W., Friedman, John D., Mark Hyun, R. James Gerlach, Miranda-Peats, Romalisa, Slomka, Piotr, Thomson, Louise, Pierre Mongeon, Francois, Michael, Steven, Hung, Judy, Zeng, Xin, Eckstein, Jane, Guruge, Bandula, Streif, Mary, Alfonso, Maria A., Corral, Maria P., Garcia, Javier J., Horst, Jennifer, Jankovic, Ivana, Konigstein, Maayan, Lustre, Mitchel B., Peralta, Yolayfi, Sanchez, Raquel, Arsanjani, Reza, Elmor, Kimberly, Gomez, Millie, Hindoyan, Niree, Nakanishi, Rine, Barbara Srichai-Parsia, M., Yeoh, Eunice, Youn, Tricia, Bianchini, Francesca, Ceseri, Martina, Lorimer, Andrea, Magnoni, Marco, Orso, Francesco, Sarti, Laura, Mazza Barbosa, Lilian, Bello Duarte, Tauane, Colaiácovo Soares, Tamara, de Aveiro Morata, Julia, Carvalho, Pedro, de Carvalho Maffei, Natalia, Egydio, Flávia, Kawak, Anelise, Oliveira, Janaina, Restelli Piloto, Elissa, Pozzibon, Jaqueline, Camara, Diane, Mowafy, Neamat, Spindler, Caroline, Dai, Hao, Feng, Fang, Li, Jia, Li, Li, Liu, Jiamin, Xie, Qiulan, Zhang, Haibo, Zhang, Jianxin, Zhang, Lihua, Zhang, Liping, Zhang, Ning, Zhong, Hui, Escobar, Claudia, Eugenia Martin, Maria, Pascual, Andrea, Moraga, Paloma, Hernandez, Victoria, Posada, Maria, Fernandez, Sara, Luis Narro Villanueva, José, Selgas, Rafael, Luyten, Ann, Garcevic, Nevena, Stojkovic, Jelena, Ahmed, Asker, Bhatt, Richa, Chadha, Nitika, Kumar, Vijay, Lubna, Sadath, Naik, Pushpa, Pandey, Shruti, Ramasamy, Karthik, Saleem, Mohammed, Sharma, Pratiksha, and Siddaram, Hemalata

Published
2024
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23. In vivo imaging and quantification of carbonic anhydrase IX expression as an endogenous biomarker of tumor hypoxia.

Author

Bagna Bao, Kevin Groves, Jun Zhang, Emma Handy, Paul Kennedy, Garry Cuneo, Claudiu T Supuran, Wael Yared, Milind Rajopadhye, and Jeffrey D Peterson

Subjects
Medicine, Science
Abstract

Carbonic anhydrase IX (CA IX) is a transmembrane protein that has been shown to be greatly upregulated under conditions of hypoxia in many tumor cell lines. Tumor hypoxia is associated with impaired efficacy of cancer therapies making CA IX a valuable target for preclinical and diagnostic imaging. We have developed a quantitative in vivo optical imaging method for detection of CA IX as a marker of tumor hypoxia based on a near-infrared (NIR) fluorescent derivative of the CA IX inhibitor acetazolamide (AZ). The agent (HS680) showed single digit nanomolar inhibition of CA IX as well as selectivity over other CA isoforms and demonstrated up to 25-fold upregulation of fluorescent CA IX signal in hypoxic versus normoxic cells, which could be blocked by 60%-70% with unlabeled AZ. CA IX negative cell lines (HCT-116 and MDA-MB-231), as well as a non-binding control agent on CA IX positive cells, showed low fluorescent signal under both conditions. In vivo FMT imaging showed tumor accumulation and excellent tumor definition from 6-24 hours. In vivo selectivity was confirmed by pretreatment of the mice with unlabeled AZ resulting in >65% signal inhibition. HS680 tumor signal was further upregulated >2X in tumors by maintaining tumor-bearing mice in a low oxygen (8%) atmosphere. Importantly, intravenously injected HS680 signal was co-localized specifically with both CA IX antibody and pimonidazole (Pimo), and was located away from non-hypoxic regions indicated by a Hoechst stain. Thus, we have established a spatial correlation of fluorescence signal obtained by non-invasive, tomographic imaging of HS680 with regions of hypoxia and CA IX expression. These results illustrate the potential of HS680 and combined with FMT imaging to non-invasively quantify CA IX expression as a hypoxia biomarker, crucial to the study of the underlying biology of hypoxic tumors and the development and monitoring of novel anti-cancer therapies.

Published
2012
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24. Redetermination of cis-diaquadiglycolatozinc(II)

Author

Margaret E. Kastner, David Rovnyak, Neferterneken Francis, and Paul Kennedy

Subjects
Crystallography, QD901-999
Abstract

The title complex, [Zn(C2H3O3)2(H2O)2], was prepared and the crystal structure determined as part of a 67Zn solid state nuclear magnetic resonance study. In the title complex, the Zn atom has a disorted octahedral coordination comprising two bidentate glycolate ligands and two water molecules. The water molecules are cis to each other; one is trans to a carboxylate O atom and the other trans to an alcohol O atom. The crystal structure has an extensive O—H...O hydrogen-bond network.

Published
2008
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25. Forming a Rural Health Partnership Network

Author

Karl Hamner, Paul Kennedy, and Tim Wolfe

Subjects
Education, Communities. Classes. Races, HT51-1595
Abstract

Walker County, Alabama, population 70,713, typifies health challenges in rural America. The county is poor with per capita income $10,000 below the national average. It lacks an adequate health care infrastructure — 4 physicians per 10,000 population compared to 7 nationally. The county has severe chronic health problems. For example, there are 67 heart failure deaths per 10,000 population compared to 20 nationally (Alabama Community Health Resource Guide, 2008). There are many other similar statistics, but a new conjunction of health care providers and leaders offers promise for a united approach in Walker County.

Published
2008
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26. Staff development at RMIT: bottom-up work serviced by top-down investment and policy

Author

Carmel McNaught and Paul Kennedy

Subjects
Education
Abstract

What is the business of a university in the 1990s and 2000s? Quantity and quality are both important considerations in modern universities as they seek to maintain important intellectual and physical spaces for their staff to pursue creative research and development, while at the same time needing to provide teaching for escalating numbers of students in all courses in order to shore up funding. These student cohorts have become increasingly diverse (Mclnnis, James and McNaught, 1995) with more part-time students and students from a greater variety of backgrounds. Flexible modes of delivery have been widely viewed as the prime way of meeting the challenges posed by this diversity. There has been a fair amount of naive equating of flexible delivery with production of online materials ('Plug them into the Web') and insufficient attention to the relationship between flexible modes of operation for students, the use of communication and information technologies, and the design of educationally sound learning environments (Kennedy and McNaught, 1997; Reeves and Reeves, 1997). However, there is no doubt that communication and information technologies will be a major part of future university planning, as several recent reports make clear (e.g. Yetton et al., 1997).

Published
2000
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28. Rapidly Changing Range Limits in a Warming World: Critical Data Limitations and Knowledge Gaps for Advancing Understanding of Mangrove Range Dynamics in the Southeastern USA

Author

Rémi Bardou, Michael J. Osland, Steven Scyphers, Christine Shepard, Karen E. Aerni, Jahson B. Alemu I, Robert Crimian, Richard H. Day, Nicholas M. Enwright, Laura C. Feher, Sarah L. Gibbs, Kiera O’Donnell, Savannah H. Swinea, Kalaina Thorne, Sarit Truskey, Anna R. Armitage, Ronald Baker, Josh L. Breithaupt, Kyle C. Cavanaugh, Just Cebrian, Karen Cummins, Donna J. Devlin, Jacob Doty, William L. Ellis, Ilka C. Feller, Christopher A. Gabler, Yiyang Kang, David A. Kaplan, John Paul Kennedy, Ken W. Krauss, Margaret M. Lamont, Kam-biu Liu, Melinda Martinez, Ashley M. Matheny, Giovanna M. McClenachan, Karen L. McKee, Irving A. Mendelssohn, Thomas C. Michot, Christopher J. Miller, Jena A. Moon, Ryan P. Moyer, James Nelson, Richard O’Connor, James W. Pahl, Jonathan L. Pitchford, C. Edward Proffitt, Tracy Quirk, Kara R. Radabaugh, Whitney A. Scheffel, Delbert L. Smee, Caitlin M. Snyder, Eric Sparks, Kathleen M. Swanson, William C. Vervaeke, Carolyn A. Weaver, Jonathan Willis, Erik S. Yando, Qiang Yao, and A. Randall Hughes

Subjects
Ecology, Aquatic Science, Ecology, Evolution, Behavior and Systematics
Abstract

Climate change is altering species’ range limits and transforming ecosystems. For example, warming temperatures are leading to the range expansion of tropical, cold-sensitive species at the expense of their cold-tolerant counterparts. In some temperate and subtropical coastal wetlands, warming winters are enabling mangrove forest encroachment into salt marsh, which is a major regime shift that has significant ecological and societal ramifications. Here, we synthesized existing data and expert knowledge to assess the distribution of mangroves near rapidly changing range limits in the southeastern USA. We used expert elicitation to identify data limitations and highlight knowledge gaps for advancing understanding of past, current, and future range dynamics. Mangroves near poleward range limits are often shorter, wider, and more shrublike compared to their tropical counterparts that grow as tall forests in freeze-free, resource-rich environments. The northern range limits of mangroves in the southeastern USA are particularly dynamic and climate sensitive due to abundance of suitable coastal wetland habitat and the exposure of mangroves to winter temperature extremes that are much colder than comparable range limits on other continents. Thus, there is need for methodological refinements and improved spatiotemporal data regarding changes in mangrove structure and abundance near northern range limits in the southeastern USA. Advancing understanding of rapidly changing range limits is critical for foundation plant species such as mangroves, as it provides a basis for anticipating and preparing for the cascading effects of climate-induced species redistribution on ecosystems and the human communities that depend on their ecosystem services.

Published
2023
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30. Performance of native and gadoxetate-enhanced liver and spleen T1 mapping for noninvasive diagnosis of clinically significant portal hypertension: preliminary results

Author

Emre Altinmakas, Octavia Bane, Stefanie J. Hectors, Rayane Issa, Guillermo Carbonell, Ghadi Abboud, Thomas D. Schiano, Swan Thung, Aaron Fischman, Matthew D. Kelly, Scott L. Friedman, Paul Kennedy, and Bachir Taouli

Subjects
Radiological and Ultrasound Technology, Urology, Gastroenterology, Radiology, Nuclear Medicine and imaging
Published
2022
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31. Genetically based adaptive trait shifts at an expanding mangrove range margin

Author

John Paul Kennedy, Giles N. Johnson, Richard F. Preziosi, and Jennifer K. Rowntree

Subjects
Aquatic Science
Abstract

Neotropical black mangrove (Avicennia germinans) is expanding poleward into temperate salt marsh along Atlantic Florida, USA, with field evidence of trait shifts consistent with greater cold tolerance within range margin populations. However, whether these shifts have a genetic basis remains unanswered. To address this gap, we measured multiple phenotypic traits of twenty A. germinans maternal cohorts from areas in both the Atlantic Florida range core and margin in a 2-year greenhouse common garden with annual temperatures analogous to range margin conditions. Compared to those from the range core, range margin cohorts survived in greater numbers, established (i.e., produced first true leaves) more quickly, and were less stressed under winter temperatures. Range margin cohorts were not taller, but invested more into lateral growth and biomass accumulation that presumably reflects adaptation to their colder and open-canopy environment. Range margin cohorts also exhibited leaf traits consistent with greater resource acquisition that may compensate for a shorter growing season and reduced light quality at higher latitude. Our results suggest that genetically based phenotypic differences better enable these range margin mangroves to thrive within their stressful environment and may facilitate further poleward expansion. An improved understanding of adaptive trait variation within ecologically important mangrove foundation species should also help inform coastal restoration initiatives.

Published
2022
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32. Neoadjuvant cemiplimab for resectable hepatocellular carcinoma: a single-arm, open-label, phase 2 trial

Author

Thomas U Marron, Maria Isabel Fiel, Pauline Hamon, Nathalie Fiaschi, Edward Kim, Stephen C Ward, Zhen Zhao, Joel Kim, Paul Kennedy, Ganesh Gunasekaran, Parissa Tabrizian, Deborah Doroshow, Meredith Legg, Ashley Hammad, Assaf Magen, Alice O Kamphorst, Muhammed Shareef, Namita T Gupta, Raquel Deering, Wei Wang, Fang Wang, Pradeep Thanigaimani, Jayakumar Mani, Leanna Troncoso, Alexandra Tabachnikova, Christie Chang, Guray Akturk, Mark Buckup, Steven Hamel, Giorgio Ioannou, Clotilde Hennequin, Hajra Jamal, Haley Brown, Antoinette Bonaccorso, Daniel Labow, Umut Sarpel, Talia Rosenbloom, Max W Sung, Baijun Kou, Siyu Li, Vladimir Jankovic, Nicola James, Sara C Hamon, Hung Kam Cheung, Jennifer S Sims, Elizabeth Miller, Nina Bhardwaj, Gavin Thurston, Israel Lowy, Sacha Gnjatic, Bachir Taouli, Myron E Schwartz, and Miriam Merad

Subjects
Carcinoma, Hepatocellular, Hepatology, Liver Neoplasms, Gastroenterology, Humans, Chemoembolization, Therapeutic, Article, Neoadjuvant Therapy
Abstract

BACKGROUND: Surgical resection of early stage hepatocellular carcinoma is standard clinical practice; however, most tumours recur despite surgery, and no perioperative intervention has shown a survival benefit. Neoadjuvant immunotherapy has induced pathological responses in multiple tumour types and might decrease the risk of postoperative recurrence in hepatocellular carcinoma. We aimed to evaluate the clinical activity of neoadjuvant cemiplimab (an anti-PD-1) in patients with resectable hepatocellular carcinoma. METHODS: For this single-arm, open-label, phase 2 trial, patients with resectable hepatocellular carcinoma (stage Ib, II, and IIIb) were enrolled and received two cycles of neoadjuvant cemiplimab 350 mg intravenously every 3 weeks followed by surgical resection. Eligible patients were aged 18 years or older, had confirmed resectable hepatocellular carcinoma, an Eastern Cooperative Oncology Group performance status of 0 or 1, and adequate liver function. Patients were excluded if they had metastatic disease, if the surgery was not expected to be curative, if they had a known additional malignancy requiring active treatment, or if they required systemic steroid treatment or any other immunosuppressive therapy. After resection, patients received an additional eight cycles of cemiplimab 350 mg intravenously every 3 weeks in the adjuvant setting. The primary endpoint was significant tumour necrosis on pathological examination (defined as >70% necrosis of the resected tumour). Secondary endpoints included delay of surgery, the proportion of patients with an overall response, change in CD8(+) T-cell density, and adverse events. Tumour necrosis and response were analysed in all patients who received at least one dose of cemiplimab and completed surgical resection; safety and other endpoints were analysed in the intention-to-treat population. Patients underwent pre-treatment biopsies and blood collection throughout treatment. This trial is registered with ClinicalTrials.gov (NCT03916627, Cohort B) and is ongoing. FINDINGS: Between Aug 5, 2019, and Nov 25, 2020, 21 patients were enrolled. All patients received neoadjuvant cemiplimab, and 20 patients underwent successful resection. Of the 20 patients with resected tumours, four (20%) had significant tumour necrosis. Three (15%) of 20 patients had a partial response, and all other patients maintained stable disease. 20 (95%) patients had a treatment-emergent adverse event of any grade during the neoadjuvant treatment period. The most common adverse events of any grade were increased aspartate aminotransferase (in four patients), increased blood creatine phosphokinase (in three), constipation (in three), and fatigue (in three). Seven patients had grade 3 adverse events, including increased blood creatine phosphokinase (in two patients) and hypoalbuminaemia (in one). No grade 4 or 5 events were observed. One patient developed pneumonitis, which led to a delay in surgery by 2 weeks. INTERPRETATION: This report is, to our knowledge, the largest clinical trial of a neoadjuvant anti-PD-1 monotherapy reported to date in hepatocellular carcinoma. The observed pathological responses to cemiplimab in this cohort support the design of larger trials to identify the optimal treatment duration and definitively establish the clinical benefit of preoperative PD-1 blockade in patients with hepatocellular carcinoma. FUNDING: Regeneron Pharmaceuticals.

Published
2022
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33. Supplemental Tables from Pilot and Feasibility Trial Evaluating Immuno-Gene Therapy of Malignant Mesothelioma Using Intrapleural Delivery of Adenovirus-IFNα Combined with Chemotherapy

Author

Steven M. Albelda, Corey J. Langer, Melissa Culligan, Charles B. Simone, Keith A. Cengel, Luis J. Montaner, Paul Kennedy, Emmanouil Papasavvas, Kay See Tan, Jennifer H. Yearley, Leslie Litzky, Wei-Ting Hwang, Daniel F. Heitjan, Jing Sun, Sharyn I. Katz, Anil Vachani, Andrew R. Haas, Edmund K. Moon, Adri Recio, Susan Metzger, Joseph Friedberg, James P. Stevenson, Evan Alley, and Daniel H. Sterman

Abstract

Supplemental Tables 1-6 Supplemental Table 1. Results of some recent trials of chemotherapy in MPM. Supplemental Table 2. Post-Trial Therapies Supplemental Table 3. Characteristics of Patients Selected for Flow Cytometry Analysis Supplemental Table 4. List of Immune Response Genes assayed by Nanostring Supplemental Table 5: Correlation of Antibody Response to MOS or Radiographic Response Supplemental Table 6. Flow Cytometry Results

Published
2023
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34. Data from Pilot and Feasibility Trial Evaluating Immuno-Gene Therapy of Malignant Mesothelioma Using Intrapleural Delivery of Adenovirus-IFNα Combined with Chemotherapy

Author

Steven M. Albelda, Corey J. Langer, Melissa Culligan, Charles B. Simone, Keith A. Cengel, Luis J. Montaner, Paul Kennedy, Emmanouil Papasavvas, Kay See Tan, Jennifer H. Yearley, Leslie Litzky, Wei-Ting Hwang, Daniel F. Heitjan, Jing Sun, Sharyn I. Katz, Anil Vachani, Andrew R. Haas, Edmund K. Moon, Adri Recio, Susan Metzger, Joseph Friedberg, James P. Stevenson, Evan Alley, and Daniel H. Sterman

Abstract

Purpose: “In situ vaccination” using immunogene therapy has the ability to induce polyclonal antitumor responses directed by the patient's immune system.Experimental Design: Patients with unresectable malignant pleural mesothelioma (MPM) received two intrapleural doses of a replication-defective adenoviral vector containing the human IFNα2b gene (Ad.IFN) concomitant with a 14-day course of celecoxib followed by chemotherapy. Primary outcomes were safety, toxicity, and objective response rate; secondary outcomes included progression-free and overall survival. Biocorrelates on blood and tumor were measured.Results: Forty subjects were treated: 18 received first-line pemetrexed-based chemotherapy, 22 received second-line chemotherapy with pemetrexed (n = 7) or gemcitabine (n = 15). Treatment was generally well tolerated. The overall response rate was 25%, and the disease control rate was 88%. Median overall survival (MOS) for all patients with epithelial histology was 21 months versus 7 months for patients with nonepithelial histology. MOS in the first-line cohort was 12.5 months, whereas MOS for the second-line cohort was 21.5 months, with 32% of patients alive at 2 years. No biologic parameters were found to correlate with response, including numbers of activated blood T cells or NK cells, regulatory T cells in blood, peak levels of IFNα in blood or pleural fluid, induction of antitumor antibodies, nor an immune-gene signature in pretreatment biopsies.Conclusions: The combination of intrapleural Ad.IFN, celecoxib, and chemotherapy proved safe in patients with MPM. OS rate was significantly higher than historical controls in the second-line group. Results of this study support proceeding with a multicenter randomized clinical trial of chemo-immunogene therapy versus standard chemotherapy alone. Clin Cancer Res; 22(15); 3791–800. ©2016 AACR.

Published
2023
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35. Supplementary Figure Legends from Pilot and Feasibility Trial Evaluating Immuno-Gene Therapy of Malignant Mesothelioma Using Intrapleural Delivery of Adenovirus-IFNα Combined with Chemotherapy

Author

Steven M. Albelda, Corey J. Langer, Melissa Culligan, Charles B. Simone, Keith A. Cengel, Luis J. Montaner, Paul Kennedy, Emmanouil Papasavvas, Kay See Tan, Jennifer H. Yearley, Leslie Litzky, Wei-Ting Hwang, Daniel F. Heitjan, Jing Sun, Sharyn I. Katz, Anil Vachani, Andrew R. Haas, Edmund K. Moon, Adri Recio, Susan Metzger, Joseph Friedberg, James P. Stevenson, Evan Alley, and Daniel H. Sterman

Abstract

Legends for the Supplementary Figures

Published
2023
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36. Supplementary Methods from Pilot and Feasibility Trial Evaluating Immuno-Gene Therapy of Malignant Mesothelioma Using Intrapleural Delivery of Adenovirus-IFNα Combined with Chemotherapy

Author

Steven M. Albelda, Corey J. Langer, Melissa Culligan, Charles B. Simone, Keith A. Cengel, Luis J. Montaner, Paul Kennedy, Emmanouil Papasavvas, Kay See Tan, Jennifer H. Yearley, Leslie Litzky, Wei-Ting Hwang, Daniel F. Heitjan, Jing Sun, Sharyn I. Katz, Anil Vachani, Andrew R. Haas, Edmund K. Moon, Adri Recio, Susan Metzger, Joseph Friedberg, James P. Stevenson, Evan Alley, and Daniel H. Sterman

Abstract

Additional Trial related information and methods

Published
2023
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37. Supplementary Figures from Pilot and Feasibility Trial Evaluating Immuno-Gene Therapy of Malignant Mesothelioma Using Intrapleural Delivery of Adenovirus-IFNα Combined with Chemotherapy

Author

Steven M. Albelda, Corey J. Langer, Melissa Culligan, Charles B. Simone, Keith A. Cengel, Luis J. Montaner, Paul Kennedy, Emmanouil Papasavvas, Kay See Tan, Jennifer H. Yearley, Leslie Litzky, Wei-Ting Hwang, Daniel F. Heitjan, Jing Sun, Sharyn I. Katz, Anil Vachani, Andrew R. Haas, Edmund K. Moon, Adri Recio, Susan Metzger, Joseph Friedberg, James P. Stevenson, Evan Alley, and Daniel H. Sterman

Abstract

Supplemental Figure 1. Immunoblots of Patient Serum before and after Therapy Supplemental Figure 2. Distribution of 1/Nab Titers for the 40 Patients Supplemental Figure 3. Distribution of the Day 2 serum levels of Interferon-alpha Supplemental Figure 4. Lack of Correlation of lymphocyte or macrophage infiltration with survival. Supplemental Figure 5. Lack of Correlation of PDL1 staining with survival. Supplemental Figure 6. Correlation of the mRNA immunoscore with survival.

Published
2023
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38. 'That Student Should be a Lion Tamer!' StressViz: Designing a Stress Analytics Dashboard for Teachers

Author

Riordan Dervin Alfredo, Lanbing Nie, Paul Kennedy, Tamara Power, Carolyn Hayes, Hui Chen, Carolyn McGregor, Zachari Swiecki, Dragan Gašević, and Roberto Martinez-Maldonado

Abstract

In recent years, there has been a growing interest in creating multimodal learning analytics (LA) systems that automatically analyse students' states that are hard to see with the "naked eye", such as cognitive load and stress levels, but that can considerably shape their learning experience. A rich body of research has focused on detecting such aspects by capturing bodily signals from students using wearables and computer vision. Yet, little work has aimed at designing end-user interfaces that visualise physiological data to support tasks deliberately designed for students to learn from stressful situations. This paper addresses this gap by designing a stress analytics dashboard that encodes students' physiological data into stress levels during different phases of an authentic team simulation in the context of nursing education. We conducted a qualitative study with teachers to understand (i) how they made sense of the stress analytics dashboard; (ii) the extent to which they trusted the dashboard in relation to students' cortisol data; and (iii) the potential adoption of this tool to communicate insights and aid teaching practices.

Published
2023
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40. A perspective on current therapeutic molecule screening methods against ‘Candidatus Liberibacter asiaticus’, the presumed causative agent of citrus Huanglongbing

Author

John Paul Kennedy, Kimberly Wood, Marco Pitino, Kranthi Mandadi, David O. Igwe, Robert Shatters, Timothy L. Widmer, Randall Niedz, and Michelle Heck

Subjects
Plant Science, Agronomy and Crop Science
Abstract

Huanglongbing (HLB), referred to as citrus greening disease, is a bacterial disease impacting citrus production worldwide and fatal in young trees and certain varieties. In some areas, the disease is devastating the citrus industry. A successful solution to HLB will be measured in economics: Citrus growers need treatments that improve tree health, fruit production, and most importantly economic yield. The profitability of citrus groves is the ultimate metric that truly matters when searching for solutions to HLB. Scientific approaches used in the laboratory, greenhouse, or field trials are critical to discovery of those solutions and to estimate the likelihood of success of a treatment aimed for commercialization. Researchers and the citrus industry use a number of proxy evaluations of potential HLB solutions and understanding the strengths and limitations of each assay as well as how best to compare different assays is critical for decision making to advance therapies into field trials and commercialization. This perspective aims to help the reader compare and understand the limitations of different proxy evaluation systems based on the treatment and evaluation under consideration. The researcher must determine the suitability of one or more of these metrics to identify treatments and predict the usefulness of these treatments in having an eventual impact on citrus production and HLB mitigation. As therapies advance to field trials in the next few years, a re-evaluation of these metrics will be useful to guide future research efforts on strategies to mitigate HLB and vascular bacterial pathogens in other perennial crops.

Published
2023
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43. Sources, Composition, and Export of Particulate Organic Matter Across British Estuaries

Author

E. Elena García‐Martín, Richard Sanders, Chris D. Evans, Vassilis Kitidis, Dan J. Lapworth, Bryan M. Spears, Andy Tye, Jennifer L. Williamson, Chris Balfour, Mike Best, Michael Bowes, Sarah Breimann, Ian J. Brown, Annette Burden, Nathan Callaghan, Nancy B. Dise, Gareth Farr, Stacey L. Felgate, James Fishwick, Mike Fraser, Stuart Gibb, Pete J. Gilbert, Nina Godsell, Africa P. Gomez‐Castillo, Geoff Hargreaves, Carolyn Harris, Oban Jones, Paul Kennedy, Anna Lichtschlag, Adrian P. Martin, Rebecca May, Edward Mawji, Ian Mounteney, Philip D. Nightingale, Justyna P. Olszewska, Stuart C. Painter, Christopher R. Pearce, M. Glória Pereira, Kate Peel, Amy Pickard, John A. Stephens, Mark Stinchcombe, Barry Thornton, E. Malcolm S. Woodward, Deborah Yarrow, and Daniel J. Mayor

Subjects
particulate matter, Atmospheric Science, terrigenous material, Ecology, land ocean aquatic continuum, Paleontology, Soil Science, Forestry, Oceanografi, hydrologi och vattenresurser, Aquatic Science, Ecology and Environment, Marine Sciences, Oceanography, Hydrology and Water Resources, isotopic signatures, Water Science and Technology
Abstract

Estuaries receive and process a large amount of particulate organic carbon (POC) prior to its export into coastal waters. Studying the origin of this POC is key to understanding the fate of POC and the role of estuaries in the global carbon cycle. Here, we evaluated the concentrations of POC, as well as particulate organic nitrogen (PON), and used stable carbon and nitrogen isotopes to assess their sources across 13 contrasting British estuaries during five different sampling campaigns over 1 year. We found a high variability in POC and PON concentrations across the salinity gradient, reflecting inputs, and losses of organic material within the estuaries. Catchment land cover appeared to influence the contribution of POC to the total organic carbon flux from the estuary to coastal waters, with POC contributions >36% in estuaries draining catchments with a high percentage of urban/suburban land, and

Published
2023

45. Initial Invasive or Conservative Strategy for Stable Coronary Disease

Author

Maron D. J., Hochman J. S., Reynolds H. R., Bangalore S., O'Brien S. M., Boden W. E., Chaitman B. R., Senior R., Lopez-Sendon J., Alexander K. P., Lopes R. D., Shaw L. J., Berger J. S., Newman J. D., Sidhu M. S., Goodman S. G., Ruzyllo W., Gosselin G., Maggioni A. P., White H. D., Bhargava B., Min J. K., John Mancini G. B., Berman D. S., Picard M. H., Kwong R. Y., Ali Z. A., Mark D. B., Spertus J. A., Krishnan M. N., Elghamaz A., Moorthy N., Hueb W. A., Demkow M., Mavromatis K., Bockeria O., Peteiro J., Miller T. D., Szwed H., Doerr R., Keltai M., Selvanayagam J. B., Gabriel Steg P., Held C., Kohsaka S., Mavromichalis S., Kirby R., Jeffries N. O., Harrell F. E., Rockhold F. W., Broderick S., Bruce Ferguson T., Williams D. O., Harrington R. A., Stone G. W., Rosenberg Y, ISCHEMIA Research Group: Joseph Ricci, A Tello Montoliu, A I Robero Aniorte, Abbey Mulder, Abhay A Laddu, Abhinav Goyal, Abhishek Dubey, Abhishek Goyal, Abigail Knighton, Abraham Oomman, Adam J Jaskowiak, Adam Kolodziej, Adam Witkowski, Adnan Hameed, Adriana Anesini, Afshan Hussain, Agne Juceviciene, Agne Urboniene, Agnes Jakal, Agnieszka Szramowska, Ahmad Khairuddin, Ahmed Abdel-Latif, Ahmed Adel, Ahmed Aljzeeri, Ahmed Kamal, Ahmed Talaat, Aimee Mann, Aira Contreras, Ajit Kumar, V K Kumar, Akemi Furukawa, Akshay Bagai, Akvile Smigelskaite, Alain Furber, Alain Rheault, Alaine Melanie Loehr, Alan Rosen, Albert Varga, Albertina Qelaj, Alberto Barioli, Aldo Russo, Alec Moorman, Alejandro Gisbert, Aleksandra Fratczak, Aleksandras Laucevicius, Alena Kuleshova, Alessandro Sionis, Alexander A Sirker, Alexander M Chernyavskiy, Alexandra Craft, Alexandra Vazquez, Alexandre Ciappina Hueb, Alexandre S Colafranseschi, Alexandre Schaan de Quadros, Alexandre Tognon, Ali Alghamdi, Alice Manica Muller, Aline Nogueira Rabaça, Aline Peixoto Deiro, Alison Hallam, Allegra Stone, Allison Schley, Almudena Castro, Alvaro Rabelo Ales, Amanda Germann, Amanda O'Malley, Amar Uxa, Amarachi Ojajuni, Amarino C Oliveira Jr, Amber B Hull, Ambuj Roy, Amer Zarka, Amir Janmohamed, Ammani Brown, Ammy Malinay, Amparo Martinez Monzonis, Amy J Richards, Amy Iskandrian, Amy Ollinger, Ana D Djordjevic-Dikic, Ana Fernández Martínez, Ana Gomes Almeida, Ana Paula Batista, Ana Rita Francisco, Ana S Mladenovic, Ana Santana, Anam Siddiqui, Anastasia M Kuzmina-Krutetskaya, Andras Vertes, Andre S Sousa, Andre Gabriel, André Schmidt, Andrea M Lundeen, Andrea Bartykowszki, Andrea Lorimer, Andrea Mortara, Andrea Pascual, Andreia Coelho, Andreia Rocha, Andrés García-Rincón, Andrew G Howarth, Andrew J Moriarty, Andrew Docherty, Andrew Starovoytov, Andrew Zurick, Andrzej Łabyk, Andrzej Swiatkowski, Andy Lam, Anelise Kawakami, Angela Hoye, Angela Kim, Angelique Smit, Angelo Nobre, Anil V Shah, Anja Ljubez, Anjali Anand, Ankush Sachdeva, Ann Greenberg, Ann Luyten, Ann Ostrander, Anna Di Donato, Anna Cichocka-Radwan, Anna Fojt, Anna Plachcinska, Anna Proietti, Anna Teresinska, Anne Marie Webb, Anne Cartwright, Anne Heath, Anne Mackin, Anong Amaritakomol, Anong Chaiyasri, Anoop Chauhan, Anoop Mathew, Anthony Gemignani, Anto Luigi Andres, Antonia Vega, Antonietta Hansen, Antonino Ginel Iglesias, Antonio Carlos Carvalho, Antonio Di Chiara, Antonio Serra Peñaranda, Antonio Carvalho, Antonio Colombo, Antonio Fiarresga, Anupama Rao, Aquiles Valdespino-Estrada, Araceli Boan, Areef Ishani, Ariel Diaz, Arijit Ghosh, Arintaya Prommintikul, Arline Roberts, Arnold H Seto, Arnold P Good, Arshed Quyyumi, Arthur J Labovitz, Arthur Kerner, Arturo S Campos-Santaolalla, Arunima Misra, Ashok Mukherjee, Ashok Seth, Ashraf Seedhom, Asim N Cheema, Asker Ahmed, Atul Mathur, Atul Verma, Audrey W Leong, Axel Åkerblom, Axelle Fuentes, Aynun Naher, Badhma Valaiyapathi, Baljeet Kaur, Bandula Guruge, Barbara Brzezińska, Barbara Nardi, Bartosz Czarniak, Bebek Singh, Begoña Igual, Bela Merkely, Belen Cid Alvarez, Benjamin J Spooner, Benjamin J W Chow, Benjamin Cheong, Benoy N Shah, Bernard de Bruyne, Bernardas Valecka, Bernhard Jäger, Beth A Archer, Beth Abramson, Beth Jorgenson, Bethany Harvey, Betsy O'Neal, Bev Atkinson, Bev Bozek, Bevin Lang, Bijulal Sasidharan, Bin Yang, Bin Zhang, Binoy Mannekkattukudy Kurian, Bjoern Goebel, Bob Hu, Bogdan A Popescu, Bogdan Crnokrak, Bolin Zhu, Bonnie J Kirby, Brandi D Zimbelman, Brandy Starks, Branko D Beleslin, Brenda Hart, Brian P Shapiro, Brian McCandless, Brianna Wisniewski, Brigham R Smith, Brooks Mirrer, Bruce McManus, Bruce Rutkin, Bruna Edilena Paulino, Bruna Maria Ascoli, Bryn Smith, Byron J Allen, C Michael Gibson, C Noel Bairey Merz, Calin Pop, Cameron Hague, Camila Thais de Ormundo, Candace Gopaul, Candice P Edillo, Carísi A Polanczyk, Carita Krannila, Carla Vicente, Carl-Éric Gagné, Carlo Briguori, Carlos Peña Gil, Carlos Alvarez, Carly Ohmart, Carmen C Beladan, Carmen Ginghina, Carol M Kartje, Caroline Alsweiler, Caroline Brown, Caroline Callison, Caroline Pinheiro, Caroline Rodgers, Caroline Spindler, Carolyn Corbett, Carrie Drum, Casey Riedberger, Catherine Bone, Catherine Fleming, Catherine Gordon, Catherine Jahrsdorfer, Catherine Lemay, Catherine Weick, Cathrine Patten, Cecilia Goletto, Cezary Kepka, Chandini Suvarna, Chang Xu, Chantale Mercure, Charle A Viljoen, Charlene Wiyarand, Charles Jia-Yin Hou, Charles Y Lui, Charles Cannan, Charles Cornet, Charlotte Pirro, Chataroon Rimsukcharoenchai, Chen Wang, Cheng-Ting Tsai, Chen-Yen Chien, Cheryl A Allardyce, Chester M Hedgepeth, Chetan Patel, Chiara Attanasio, Chih-Hsuan Yen, Chi-Ming Chow, Ching Min Er, Ching-Ching Ong, Cholenahally Nanjappa Manjunath, Chris Beck, Chris Buller, Christel Vassaliere, Christian Hamm, Christiano Caldeira, Christie Ballantyne, Christina Björklund, Christine R Hinton, Christine Bergeron, Christine Masson, Christine Roraff, Christine Shelley, Christophe Laure, Christophe Thuaire, Christopher Kinsey, Christopher McFarren, Christopher Spizzieri, Christopher Travill, Chun-Chieh Liu, Chung-Lieh Hung, Chunguang Li, Chun-Ho Yun, Chunli Xia, Ciarra Heard, Cidney Schultz, Clare Venn-Edmonds, Claudia P Hochberg, Claudia Wegmayr, Claudia Cortés, Claudia Escobar, Cláudia Freixo, Claudio T Mesquita, Clemens T Kadalie, Colin Berry, Constance Philander, Corine Thobois, Costantino Costantini, Courtney Page, Craig Atkinson, Craig Barr, Craig Paterson, Cristina Bare, Cynthia Baumann, Cynthia Burman, Dalisa Espinosa, Damien Collison, Dan Deleanu, Dan Elian, Dan Gao, Dana Oliver, Daniel P Vezina, Daniel O'Rourke, Daniele Komar, Danielle Schade, Darrel P Francis, Dastan Malaev, David A Bull, David E Winchester, David P Faxon, David Booth, David Cohen, David DeMets, David Foo, David Schlichting, David Taggart, David Waters, David Wohns, Davis Vo, Dawid Teodorczyk, Dawn Shelstad, Dawn Turnbull, Dayuan Li, Dean Kereiakes, Deborah O'Neill, Deborah Yip, Debra K Johnson, Debra Dees, Deepak L Bhatt, Deepika Gopal, Deepti Kumar, Deirdre Mattina, Deirdre Murphy, Delano R Small, Delsa K Rose, Dengke Jiang, Denis Carl Phaneuf, Denise Braganza, Denise Fine, Derek Cyr, Desiree Tobin, Diana Cukali, Diana Parra, Diane Camara, Diane Minshall Liu, Diego Adrián Vences, Diego Franca de Cunha, Dimitrios Stournaras, Dipti Patel, Dongze Li, Donna Exley, Dorit Grahl, Dragana Stanojevic, Duarte Cacela, Dwayne S G Conway, E Pinar Bermudez, Eapen Punnoose, Edgar L Tay, Edgar Karanjah, Edoardo Verna, Eduardo Hernandez-Rangel, Edward D Nicol, Edward O McFalls, Edward T Martin, Edyta Kaczmarska, Ekaterina I Lubinskaya, Elena A Demchenko, Elena Refoyo Salicio, Eli Feen, Elihú Durán-Cortés, Elisabeth M Janzen, Elise L Hannemann, Elise van Dongen, Elissa Restelli Piloto, Eliza Kaplan, Elizabeta Srbinovska Kostovska, Elizabeth Capasso-Gulve, Elizabeth Congdon, Elizabeth Ferguson, Elizaveta V Zbyshevskaya, Ellen Magedanz, Ellie Fridell, Ellis W Lader, Elvin Kedhi, Emanuela Racca, Emilie Tachot, Emily DeRosa, Encarnación Alonso-Álvarez, Eric Nicollet, Eric Peterson, Erick Alexánderson Rosas, Erick Donato Morales, Erin Orvis, Ermina Moga, Estelle Montpetit, Estevao Figueiredo, Eugene Passamani, Eugenia Nikolsky, Eunice Yeoh, Evgeniy I Kretov, Ewa Szczerba, Ewelina Wojtala, Expedito Eustáquio Ribeiro Silva, F Marin Ortuño, Fabio R Farias, Fabio Fimiani, Fabrizio Rolfo, Fa-Chang Yu, Fadi Hage, Fadi Matar, Fahim Haider Jafary, Fang Feng, Fang Liu, Fatima Ranjbaran, Fatima Rodriguez, Fausto J Pinto, Fauzia Rashid, Federica Ramani, Fei Wang, Fernanda Igansi, Filipa Silva, Filippo Ottani, Fiona Haines, Firas Al Solaiman, Flávia Egydio, Flavio Lyra, Florian Egger, Fran Farquharson, Frances Laube, Francesc Carreras Costa, Francesca de Micco, Francesca Bianchini, Francesca Pezzetta, Francesca Pietrucci, Francesco Orso, Francesco Pisano, Francis Burt, Francisca Patuleia Figueiras, Francisco Fernandez-Aviles, Francois Pierre Mongeon, Frans Van de Werf, Franziska Guenther, Fraser N Witherow, Fred Mohr, Frederico Dall'Orto, Fumiyuki Otsuka, G De La Morena, G Karthikeyan, Gabor Dekany, Gabor Kerecsen, Gabriel Galeote, Gabriel Grossmann, Gabriel Vorobiof, Gabriela Sanchez de Souza, Gabriela Guzman, Gabriela Zeballos, Gabriele Gabrielli, Gabriele Jakl-Kotauschek, Gail A Shammas, Gail Brandt, Gang Chen, Gary E Lane, Gary J Luckasen, Gautam Sharma, Gelmina Mikolaitiene, Gennie Yee, Georg Nickenig, George E Revtyak, George J Juang, Gerald Fletcher, Gerald Leonard, Gerard Patrick Devlin, Gerard Esposito, Gergely Ágoston, Gervasio Lamas, Geza Fontos, Ghada Mikhail, Gia Cobb, Gian Piero Perna, Gianpiero Leone, Giles Roditi, Gilles Barone-Rochette, Girish Mishra, Giuseppe Tarantini, Glenda Wong, Glenn S Hamroff, Glenn Rayos, Gong Cheng, Gonzalo Barge-Caballero, Goran Davidović, Goran Stankovic, Gordana Stevanovic, Grace Jingyan Wang, Grace M Young, Graceanne Wayser, Graciela Scaro, Graham S Hillis, Graham Wong, Grazyna Anna Szulczyk, Gregor Simonis, Gregory Kumkumian, Gretchen Ann Peichel, Grzegorz Gajos, Gudrun Steinmaurer, Guilherme G Rucatti, Guilherme Portugal, Guilhermina Cantinho Lopes, Guillem Pons Lladó, Gunnar Frostfelt, Gurpreet S Wander, Gurpreet Gulati, Gustavo Pucci, Hafidz Abd Hadi, Haibo Zhang, Haitao Wang, Halina Marciniak, Han Chen, Hanan Kerr, Hani Najm, Hanna Douglas, Hannah Phillips, Hao Dai, Haojian Dong, Haqeel Jamil, Harikrishnan Sivadasanpillai, Harry Suryapranata, Hassan Reda, Hayley Pomeroy, Heather Barrentine, Heather Golden, Heather Hurlburt, Heidi Wilson, Helen C Tucker, Helene Abergel, Hemalata Siddaram, Hermine Osseni, Herwig Schuchlenz, Hesong Zeng, Hicham Skali, Hilda Solomon, Hollie Horton, Holly Hetrick, Holly Little, Holly Park, Hongjie Chi, Hossam Mahrous, Howard A Levite, Hristo Pejkov, Huajun Li, Hugo Bloise-Adames, Hugo Marques, Hui Zhong, Hui-Min Zhang, Humayrah Hashim, Hung-I Yeh, Hussien El Fishawy, Ian Webb, Iftikhar Kullo, Igor O Grazhdankin, Ihab Hamzeh, Ikraam Hassan, Ikuko Ueda, Ileana L Pina, Ilona Tamasauskiene, Ilse Bouwhuis, Imran Arif, Ina Wenzelburger, Inês Zimbarra Cabrita, Ines Rodrigues, Inga H Robbins, Inga Soveri, Ingela Schnittger, Iqbal Karimullah, Ira M Dauber, Iram Rehman, Irena Peovska Mitevska, Irene Marthe Lang, Irina Subbotina, Irma Kalibataite-Rutkauskiene, Irni Yusnida, Isabel Estela Carvajal, Isabella C Palazzo, Isabelle Hogan, Isabelle Roy, Ishba Syed, Ishita Tejani, Ivan A Naryshkin, Ivana Jankovic, Iwona Niedzwiecka, J David Knight, Jacek Kusmierek, Jackie M White, Jackie Chow, Jacob Udell, Jacqueline E Tamis-Holland, Jacqueline Fannon, Jacquelyn A Quin, Jacquelyn Do, Jaekyeong Heo, Jakub Maksym, James E Davies, James H O'Keefe Jr, James J Jang, James Cha, James Harrison, James Hirsch, James Stafford, James Tatoulis, Jamie Rankin, Jan Henzel, Jan Orga, Jana Tancredi, Janaina Oliveira, Jane Burton, Jane Eckstein, Jane Marucci, Janet P Knight, Janet Blount, Janet Halliday, Janetta Kourzenkova, Janitha Raj, Jan-Malte Sinning, Jaqueline Pozzibon, Jaroslaw Drozdz, Jaroslaw Karwowski, Jason D Glover, Jason Loh Kwok, Jason T Call, Jason Linefsky, Jassira Gomes, Jati Anumpa, Javier J Garcia, Javier Courtis, Jay Meisner, K Jayakumar, Jayne Scales, Jean E Denaro, Jean Michel Juliard, Jean Ho, Jeanette K Stansborough, Jean-Michel Juliard, Jeanne Russo, Jeannette J M Schoep, Jeet Thambyrajah, Jeff Leimberger, Jeffery A Breall, Jeffrey A Kohn, Jeffrey C Milliken, Jeffrey Anderson, Jeffrey Blume, Jeffrey Kanters, Jeffrey Lorin, Jeffrey Moses, Jelena J Stepanovic, Jelena Celutkiene, Jelena Djokic, Jelena Stojkovic, Jenne M Jose, Jenne Manchery, Jennifer A Mull, Jennifer H Czerniak, Jennifer L Stanford, Jennifer Gillis, Jennifer Horst, Jennifer Isaacs, Jennifer Langdon, Jennifer Thomson, Jennifer Tomfohr, Jennifer White, Jen-Yuan Kuo, Jeremy Rautureau, Jerome Fleg, Jessica Berg, Jessica Rodriguez, Jessica Waldron, Jhina Patro, Jia Li, Jiajia Mao, Jiamin Liu, Jian'an Wang, Jianhua Li, Jianxin Zhang, Jie Qi, Jihyun Lyo, Jill Marcus, Jim Blankenship, Jing Zhang, Jingjing Liu, Jing-Yao Fan, Jiun-Yi Li, Jiwan Pradhan, Jiyan Chen, J M Rivera Caravaca, Jo Evans, Joan Garcia Picart, Joan Hecht, Joanna Jaroch, Joanna Zalewska, Joanne Kelly, Joanne Taaffe, João Reynaldo Abbud, João V Vitola, Joaquín V Peñafiel, Jocelyne Benatar, Jody Bindeman, Joe Sabik, Joel Klitch, Johann Christopher, Johannes Aspberg, John D Friedman, John F Beltrame, John F Heitner, John Joseph Graham, John R Davies, John Doan, John Kotter, John Kurian, John Mukai, John Pownall, Jolanta Sobolewska, Jon Kobashigawa, Jonathan L Goldberg, Jonathan W Bazeley, Jonathan Byrne, Jonathan Himmelfarb, Jonathan Leipsic, Jonean Thorsen, Jorge F Trejo Gutierrez, Jorge Escobedo, Jorik Timmer, José A Ortega-Ramírez, José Antonio Marin-Neto, Jose D Salas, Jose Enrique Castillo, Jose Francisco Saraiva, José J Cuenca-Castillo, Jose L Diez, José Luis Narro Villanueva, José Luiz da Vieira, José M Flores-Palacios, Jose Ramon Gonzalez, Jose Seijas Amigo, Jose Fragata, Josep Maria Padró, Josheph F X McGarvey Jr, Joseph Hannan, Joseph Sacco, Joseph Sweeny, Joseph Wiesel, Josephine D Abraham, Joshua P Loh, Joy Burkhardt, Joyce R White, Joyce Riestenberg-Smith, Judit Sebo, Judith L Meadows, Judith Wright, Judy Mae Foltz, Judy Hung, Judy Otis, Juergen Stumpf, Jui-Peng Tsai, Julia S Dionne, Julia de Aveiro Morata, Julie Bunke, Julie Morrow, Julio César Figal, Jun Fujita, Jun Jiang, Junhua Li, Junqing Yang, Juntima Euathrongchit, Jyotsna Garg, K Manjula Rani, K Preethi, Kaatje Goetschalckx, Kai Eggers, Kamalakar Surineni, Kanae Hirase, T R Kapilamoorthy, Karen Calfas, Karen Gratrix, Karen Hallett, Karen Hultberg, Karen Nugent, Karen Petrosyan, Karen Swan, Karolina Kryczka, Karolina Wojtczak-Soska, Karolina Wojtera, Karsten Lenk, Karthik Ramasamy, Katarzyna Łuczak, Katarzyna Malinowska, Kate Pointon, Kate Robb, Katherine Martin, Kathleen Claes, Kathryn Carruthers, Kathy E Siegel, Katia Drouin, Katie Fowler-Lehman, Kavita Rawat, Kay Rowe, Keiichi Fukuda, Keith A A Fox, Ken Mahaffey, Kendra Unterbrink, Kenneth Giedd, Kerrie Van Loo, Kerry Lee, Kerstin Bonin, Kevin R Bainey, Kevin T Harley, Kevin Anstrom, Kevin Chan, Kevin Croce, Kevin Landolfo, Kevin Marzo, Keyur Patel, Khaled Abdul-Nour, Khaled Alfakih, Khaled Dajani, Khaled Ziada, Khaula Baloch, Khrystyna Kushniriuk, Kian-Keong Poh, Kim F Ireland, Kim Holland, Kimberly Ann Byrne, Kimberly E Halverson, Kimberly Elmore, Kimberly Miller-Cox, Kiran Reddy, Kirsten J Quiles, Kirsty Abercrombie, Klaus Matschke, Konrad Szymczyk, Koo Hui Chan, Kotiboinna Preethi, Kozhaya Sokhon, Krissada Meemuk, Kristian Thygesen, Kristin M Salmi, Kristin Newby, Kristina Wippler, Kristine Arges, Kristine Teoh, Krystal Etherington, Krystyna Łoboz-Grudzień, Krzysztof W Reczuch, Krzysztof Bury, Krzysztof Drzymalski, Krzysztof Kukuła, Kuo-Tzu Sung, Kurt Huber, Ladda Douangvila, Lance Sullenberger, Larissa Miranda Trama, Laszlone Matics, Laura Drew, Laura Flint, Laura Keinaite, Laura Sarti, Laurel Kolakaluri, Lawrence M Phillips, Lawrence Friedman, Lawrence Phillips, Lazar Velicki, Leah Howell, Leandro C Maranan, Leanne Cox, Ledjalem Daba, Lei Zhang, Lekshmi Dharmarajan, Leo Bockeria, Leonardo Pizzol Caetano, Leonardo Bridi, Leonid L Bershtein, Leszek Sokalski, Li Hai Yan, Li Li, Lia Nijmeijer, Lidia Sousa, Lihong Xu, Lihua Zhang, Lili Zhang, Lilia Schiavi, Lilian Mazza Barbosa, Lillian L Khor, Lina Felix-Stern, Linda L Hall, Linda M Hollenweger, Linda Arcand, Linda Davidson-Ray, Linda Schwarz, Lindsey N Sikora, Lingping Chi, Lino Patricio, Liping Zhang, Lisa Chaytor, Lisa Hatch, Lisa McCloy, Lisa Wong, Liselotte Persson, Lixin Jiang, Liz Low, Ljiljana Pupic, Loïc Bière, Lorenzo Monti, Lori Christensen, Lori Pritchard, Loriane Black, Lori-Ann Desimone, Lori-Ann Larmand, Lorraine McGregor, Louise Morby, Louise Thomson, Luc Harvey, Luciana de Pádua Baptista, Lucilla Garcia, Ludivine Eliahou, Ludmila Helmer, Luis F Smidt, Luis Bernanrdes, Luis Guzman, Luiz A Carvalho, Luyang Xiong, Lynette L Teo, Lynn M Neeson, Lynne Winstanley, M Barbara Srichai-Parsia, M Quintana Giner, M Sowjanya Reddy, M Valdés Chávarri, M Grazia Rossi, Maarten Simoons, Maayan Konigstein, Maciej Lesiak, Maciej Olsowka, Mafalda Selas, Magalie Corfias, Magdalena Madero Rovalo, Magdalena Łanocha, Magdalena Miller, Magdalena Misztal-Teodorczyk, Magdalena Rantinella, Magdy Abdelhamid, Magnolia Jimenez, Mahboob Alam, Mahevamma Mylarappa, Mahfouz El Shahawy, Mahmoud Mohamed, Mahmud Al-Bustami, Majo X Joseph, Malgorzata Frach, Małgorzta Celińska-Spodar, Malte Helm, Manas Chacko, Mandy Murphy, Manitha Vinod, Manjula Rani, Manu Dhawan, Manuela Mombelli, Marcel Weber, Marcello Galvani, Marcelo Jamus Rodrigues, Marcia F Dubin, Marcia F Werner Bayer, Marcin Szkopiak, Marco Antonio Monsalve, Marco Bizzaro Santos, Marco Magnoni, Marco Marini, Marco Sicuro, Marco Zenati, Marcos Valério Coimbra Resende, Marek Roik, Margalit Bentzvi, Margaret Gilsenan, Margaret Iraola, Margot C Quinn, Maria A Alfonso, Maria Antonieta Pereira Moraes, María Dolores Martínez-Ruíz, María Fernanda Canales, Maria Inês Caetano, Maria P Corral, Maria Pérez García, Maria Victoria Actis, Maria Aguirre, Maria Andreasson, Maria Aprile, Maria Colton, Maria Eugenia Martin, Maria Lasala, Maria Lorenzo, Maria Posada, Maria Shier, Maria Thottam, Mariana V Furtado, Mariana Yumi Okada, Marianna D A Dracoulakis, Marianne De Andrade, Mariano Rubio, Marie Essermark, Marielle Scherrer-Crosbie, Marija T Petrovic, Marija Zdravkovic, Marilyn Black, Marina Garcia, Mario J Garcia, Mariola Szulik, Marisa Orgera, Mark A de Belder, Mark Harbinson, Mark Hyun, Mark Peterson, Mark Xavier, Marlowe Mosley, Marta Capinha, Marta Marcinkiewicz-Siemion, Marta Swiderek, Martha Meyer, Martina Ceseri, Martina Tricoli, Marvin Kronenberg, Mary Williams, Mary Ann Champagne, Mary Colleen Rogge, Mary R Soltau, Mary Streif, Massimo Villella, Massoud Leesar, Matei Claudia, Mateusz Solecki, Matías Nicolás Mungo, Matthew Wall Jr, Matthew Budoff, Matthew Jezior, Matthew Luckie, Matthias Friedrich, Mauren P Haeffner, Maximilian Tscharre, Max-Paul Winter, Mayana Almeida, Mayil S Krishnam, Mayuri Patel, Meenakshi Mishra, Megan Manocchia, Meghana Kakade, Melanie J Munro, Melissa D Chaplin, Melissa LeFevre, Mervyn Andiapen, Michael A Gibson, Michael B Rubens, Michael C Turner, Michael D Shapiro, Michael W Lee, Michael Berlowitz, Michael Davidson, Michael Mack, Michael McDaniel, Michael Mumma, Michal Wlodarczyk, Michel G Khouri, Michel S Slama, Michele Rawlins, Michelle M Bonner, Michelle M Seib, Michelle Chang, Michelle Crowder, Michelle Dixon, Michelle Mayon, Michelle McEvoy, Michelle Yee, Miguel M Fernandes, Miguel Nobre Menezes, Miguel Souto Bayarri, Miguel Barrero, Mikhail T Torosoff, Milan R Dobric, Milan Dobric, Milica Nikola Dekleva, Milind Avdhoot Gadkari, Millie Gomez, Min Tun Kyaw, Miriam Brooks, Miroslav Stevo Martinovic, Mitchel B Lustre, Mohammad Tariq Vakani, Mohammad El-Hajjar, Mohammed Al-Amoodi, 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Riezebos, Robert M Donnino, Robert Bojar, Robert Chilton, Robert Guyton, Robert Henderson, Robert Kornberg, Robert Leber, Robert Mao, Robert Stenberg, Roberta P Santos, Roberto René Favaloro, Roberto Amati, Rodolfo G S D Lima, Rodrigo J Cerci, Rogerio Tumelero, Rohit Tandon, Roma Tewari, Romalisa Miranda-Peats, Ron Wald, Ronald A Mastouri, Ronald G Morford, Ronald G Schwartz, Ronald P Pedalino, Rongrong Hu, Ronnell A Hansen, Ronny A Cohen, Rory Hachamovitch, Rosa Homem, Rosa Sandonato, Rosane Laimer, Rosann Gans, Roxanne Yost, Roy Mathew, Rubén Baleón-Espinosa, Ruben Ramos, Rubine Gevorgyan, Rui Ferreira, Rui Jing, Ruth Pérez-Fernández, S K Dwivedi, S Ramakrishnan, Saadat Khan, Sabahat Bokhari, Sabu Thomas, Sadath Lubna, Sajeeda Parveen Khan, Sajeev Chakanalil Govindan, Saket Girotra, Saleem Kassam, Sallie Canada, Salvador Cruz-Flores, Samaa Mohamed, Samantha Ly, Sameh El Kaffas, Samia Massalha, Sampoornima Setty, Samuel Nwosu, Sandeep Seth, Sandeep Singh, Sander R Niehe, Sandra M 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Aira Contreras, Ajit Kumar, V K Kumar, Akemi Furukawa, Akshay Bagai, Akvile Smigelskaite, Alain Furber, Alain Rheault, Alaine Melanie Loehr, Alan Rosen, Albert Varga, Albertina Qelaj, Alberto Barioli, Aldo Russo, Alec Moorman, Alejandro Gisbert, Aleksandra Fratczak, Aleksandras Laucevicius, Alena Kuleshova, Alessandro Sionis, Alexander A Sirker, Alexander M Chernyavskiy, Alexandra Craft, Alexandra Vazquez, Alexandre Ciappina Hueb, Alexandre S Colafranseschi, Alexandre Schaan de Quadros, Alexandre Tognon, Ali Alghamdi, Alice Manica Muller, Aline Nogueira Rabaça, Aline Peixoto Deiro, Alison Hallam, Allegra Stone, Allison Schley, Almudena Castro, Alvaro Rabelo Ales, Amanda Germann, Amanda O'Malley, Amar Uxa, Amarachi Ojajuni, Amarino C Oliveira Jr, Amber B Hull, Ambuj Roy, Amer Zarka, Amir Janmohamed, Ammani Brown, Ammy Malinay, Amparo Martinez Monzonis, Amy J Richards, Amy Iskandrian, Amy Ollinger, Ana D Djordjevic-Dikic, Ana Fernández Martínez, Ana Gomes Almeida, Ana Paula Batista, Ana Rita Francisco, Ana S Mladenovic, Ana Santana, Anam Siddiqui, Anastasia M Kuzmina-Krutetskaya, Andras Vertes, Andre S Sousa, Andre Gabriel, André Schmidt, Andrea M Lundeen, Andrea Bartykowszki, Andrea Lorimer, Andrea Mortara, Andrea Pascual, Andreia Coelho, Andreia Rocha, Andrés García-Rincón, Andrew G Howarth, Andrew J Moriarty, Andrew Docherty, Andrew Starovoytov, Andrew Zurick, Andrzej Łabyk, Andrzej Swiatkowski, Andy Lam, Anelise Kawakami, Angela Hoye, Angela Kim, Angelique Smit, Angelo Nobre, Anil V Shah, Anja Ljubez, Anjali Anand, Ankush Sachdeva, Ann Greenberg, Ann Luyten, Ann Ostrander, Anna Di Donato, Anna Cichocka-Radwan, Anna Fojt, Anna Plachcinska, Anna Proietti, Anna Teresinska, Anne Marie Webb, Anne Cartwright, Anne Heath, Anne Mackin, Anong Amaritakomol, Anong Chaiyasri, Anoop Chauhan, Anoop Mathew, Anthony Gemignani, Anto Luigi Andres, Antonia Vega, Antonietta Hansen, Antonino Ginel Iglesias, Antonio Carlos Carvalho, Antonio Di Chiara, Antonio Serra Peñaranda, Antonio Carvalho, Antonio Colombo, Antonio Fiarresga, Anupama Rao, Aquiles Valdespino-Estrada, Araceli Boan, Areef Ishani, Ariel Diaz, Arijit Ghosh, Arintaya Prommintikul, Arline Roberts, Arnold H Seto, Arnold P Good, Arshed Quyyumi, Arthur J Labovitz, Arthur Kerner, Arturo S Campos-Santaolalla, Arunima Misra, Ashok Mukherjee, Ashok Seth, Ashraf Seedhom, Asim N Cheema, Asker Ahmed, Atul Mathur, Atul Verma, Audrey W Leong, Axel Åkerblom, Axelle Fuentes, Aynun Naher, Badhma Valaiyapathi, Baljeet Kaur, Bandula Guruge, Barbara Brzezińska, Barbara Nardi, Bartosz Czarniak, Bebek Singh, Begoña Igual, Bela Merkely, Belen Cid Alvarez, Benjamin J Spooner, Benjamin J W Chow, Benjamin Cheong, Benoy N Shah, Bernard de Bruyne, Bernardas Valecka, Bernhard Jäger, Beth A Archer, Beth Abramson, Beth Jorgenson, Bethany Harvey, Betsy O'Neal, Bev Atkinson, Bev Bozek, Bevin Lang, Bijulal Sasidharan, Bin Yang, Bin Zhang, Binoy Mannekkattukudy Kurian, Bjoern Goebel, Bob Hu, Bogdan A Popescu, Bogdan Crnokrak, Bolin Zhu, Bonnie J Kirby, Brandi D Zimbelman, Brandy Starks, Branko D Beleslin, Brenda Hart, Brian P Shapiro, Brian McCandless, Brianna Wisniewski, Brigham R Smith, Brooks Mirrer, Bruce McManus, Bruce Rutkin, Bruna Edilena Paulino, Bruna Maria Ascoli, Bryn Smith, Byron J Allen, C Michael Gibson, C Noel Bairey Merz, Calin Pop, Cameron Hague, Camila Thais de Ormundo, Candace Gopaul, Candice P Edillo, Carísi A Polanczyk, Carita Krannila, Carla Vicente, Carl-Éric Gagné, Carlo Briguori, Carlos Peña Gil, Carlos Alvarez, Carly Ohmart, Carmen C Beladan, Carmen Ginghina, Carol M Kartje, Caroline Alsweiler, Caroline Brown, Caroline Callison, Caroline Pinheiro, Caroline Rodgers, Caroline Spindler, Carolyn Corbett, Carrie Drum, Casey Riedberger, Catherine Bone, Catherine Fleming, Catherine Gordon, Catherine Jahrsdorfer, Catherine Lemay, Catherine Weick, Cathrine Patten, Cecilia Goletto, Cezary Kepka, Chandini Suvarna, Chang Xu, Chantale Mercure, Charle A Viljoen, Charlene Wiyarand, Charles Jia-Yin Hou, Charles Y Lui, Charles Cannan, Charles Cornet, Charlotte Pirro, Chataroon Rimsukcharoenchai, Chen Wang, Cheng-Ting Tsai, Chen-Yen Chien, Cheryl A Allardyce, Chester M Hedgepeth, Chetan Patel, Chiara Attanasio, Chih-Hsuan Yen, Chi-Ming Chow, Ching Min Er, Ching-Ching Ong, Cholenahally Nanjappa Manjunath, Chris Beck, Chris Buller, Christel Vassaliere, Christian Hamm, Christiano Caldeira, Christie Ballantyne, Christina Björklund, Christine R Hinton, Christine Bergeron, Christine Masson, Christine Roraff, Christine Shelley, Christophe Laure, Christophe Thuaire, Christopher Kinsey, Christopher McFarren, Christopher Spizzieri, Christopher Travill, Chun-Chieh Liu, Chung-Lieh Hung, Chunguang Li, Chun-Ho Yun, Chunli Xia, Ciarra Heard, Cidney Schultz, Clare Venn-Edmonds, Claudia P Hochberg, Claudia Wegmayr, Claudia Cortés, Claudia Escobar, Cláudia Freixo, Claudio T Mesquita, Clemens T Kadalie, Colin Berry, Constance Philander, Corine Thobois, Costantino Costantini, Courtney Page, Craig Atkinson, Craig Barr, Craig Paterson, Cristina Bare, Cynthia Baumann, Cynthia Burman, Dalisa Espinosa, Damien Collison, Dan Deleanu, Dan Elian, Dan Gao, Dana Oliver, Daniel P Vezina, Daniel O'Rourke, Daniele Komar, Danielle Schade, Darrel P Francis, Dastan Malaev, David A Bull, David E Winchester, David P Faxon, David Booth, David Cohen, David DeMets, David Foo, David Schlichting, David Taggart, David Waters, David Wohns, Davis Vo, Dawid Teodorczyk, Dawn Shelstad, Dawn Turnbull, Dayuan Li, Dean Kereiakes, Deborah O'Neill, Deborah Yip, Debra K Johnson, Debra Dees, Deepak L Bhatt, Deepika Gopal, Deepti Kumar, Deirdre Mattina, Deirdre Murphy, Delano R Small, Delsa K Rose, Dengke Jiang, Denis Carl Phaneuf, Denise Braganza, Denise Fine, Derek Cyr, Desiree Tobin, Diana Cukali, Diana Parra, Diane Camara, Diane Minshall Liu, Diego Adrián Vences, Diego Franca de Cunha, Dimitrios Stournaras, Dipti Patel, Dongze Li, Donna Exley, Dorit Grahl, Dragana Stanojevic, Duarte Cacela, Dwayne S G Conway, E Pinar Bermudez, Eapen Punnoose, Edgar L Tay, Edgar Karanjah, Edoardo Verna, Eduardo Hernandez-Rangel, Edward D Nicol, Edward O McFalls, Edward T Martin, Edyta Kaczmarska, Ekaterina I Lubinskaya, Elena A Demchenko, Elena Refoyo Salicio, Eli Feen, Elihú Durán-Cortés, Elisabeth M Janzen, Elise L Hannemann, Elise van Dongen, Elissa Restelli Piloto, Eliza Kaplan, Elizabeta Srbinovska Kostovska, Elizabeth Capasso-Gulve, Elizabeth Congdon, Elizabeth Ferguson, Elizaveta V Zbyshevskaya, Ellen Magedanz, Ellie Fridell, Ellis W Lader, Elvin Kedhi, Emanuela Racca, Emilie Tachot, Emily DeRosa, Encarnación Alonso-Álvarez, Eric Nicollet, Eric Peterson, Erick Alexánderson Rosas, Erick Donato Morales, Erin Orvis, Ermina Moga, Estelle Montpetit, Estevao Figueiredo, Eugene Passamani, Eugenia Nikolsky, Eunice Yeoh, Evgeniy I Kretov, Ewa Szczerba, Ewelina Wojtala, Expedito Eustáquio Ribeiro Silva, F Marin Ortuño, Fabio R Farias, Fabio Fimiani, Fabrizio Rolfo, Fa-Chang Yu, Fadi Hage, Fadi Matar, Fahim Haider Jafary, Fang Feng, Fang Liu, Fatima Ranjbaran, Fatima Rodriguez, Fausto J Pinto, Fauzia Rashid, Federica Ramani, Fei Wang, Fernanda Igansi, Filipa Silva, Filippo Ottani, Fiona Haines, Firas Al Solaiman, Flávia Egydio, Flavio Lyra, Florian Egger, Fran Farquharson, Frances Laube, Francesc Carreras Costa, Francesca de Micco, Francesca Bianchini, Francesca Pezzetta, Francesca Pietrucci, Francesco Orso, Francesco Pisano, Francis Burt, Francisca Patuleia Figueiras, Francisco Fernandez-Aviles, Francois Pierre Mongeon, Frans Van de Werf, Franziska Guenther, Fraser N Witherow, Fred Mohr, Frederico Dall'Orto, Fumiyuki Otsuka, G De La Morena, G Karthikeyan, Gabor Dekany, Gabor Kerecsen, Gabriel Galeote, Gabriel Grossmann, Gabriel Vorobiof, Gabriela Sanchez de Souza, Gabriela Guzman, Gabriela Zeballos, Gabriele Gabrielli, Gabriele Jakl-Kotauschek, Gail A Shammas, Gail Brandt, Gang Chen, Gary E Lane, Gary J Luckasen, Gautam Sharma, Gelmina Mikolaitiene, Gennie Yee, Georg Nickenig, George E Revtyak, George J Juang, Gerald Fletcher, Gerald Leonard, Gerard Patrick Devlin, Gerard Esposito, Gergely Ágoston, Gervasio Lamas, Geza Fontos, Ghada Mikhail, Gia Cobb, Gian Piero Perna, Gianpiero Leone, Giles Roditi, Gilles Barone-Rochette, Girish Mishra, Giuseppe Tarantini, Glenda Wong, Glenn S Hamroff, Glenn Rayos, Gong Cheng, Gonzalo Barge-Caballero, Goran Davidović, Goran Stankovic, Gordana Stevanovic, Grace Jingyan Wang, Grace M Young, Graceanne Wayser, Graciela Scaro, Graham S Hillis, Graham Wong, Grazyna Anna Szulczyk, Gregor Simonis, Gregory Kumkumian, Gretchen Ann Peichel, Grzegorz Gajos, Gudrun Steinmaurer, Guilherme G Rucatti, Guilherme Portugal, Guilhermina Cantinho Lopes, Guillem Pons Lladó, Gunnar Frostfelt, Gurpreet S Wander, Gurpreet Gulati, Gustavo Pucci, Hafidz Abd Hadi, Haibo Zhang, Haitao Wang, Halina Marciniak, Han Chen, Hanan Kerr, Hani Najm, Hanna Douglas, Hannah Phillips, Hao Dai, Haojian Dong, Haqeel Jamil, Harikrishnan Sivadasanpillai, Harry Suryapranata, Hassan Reda, Hayley Pomeroy, Heather Barrentine, Heather Golden, Heather Hurlburt, Heidi Wilson, Helen C Tucker, Helene Abergel, Hemalata Siddaram, Hermine Osseni, Herwig Schuchlenz, Hesong Zeng, Hicham Skali, Hilda Solomon, Hollie Horton, Holly Hetrick, Holly Little, Holly Park, Hongjie Chi, Hossam Mahrous, Howard A Levite, Hristo Pejkov, Huajun Li, Hugo Bloise-Adames, Hugo Marques, Hui Zhong, Hui-Min Zhang, Humayrah Hashim, Hung-I Yeh, Hussien El Fishawy, Ian Webb, Iftikhar Kullo, Igor O Grazhdankin, Ihab Hamzeh, Ikraam Hassan, Ikuko Ueda, Ileana L Pina, Ilona Tamasauskiene, Ilse Bouwhuis, Imran Arif, Ina Wenzelburger, Inês Zimbarra Cabrita, Ines Rodrigues, Inga H Robbins, Inga Soveri, Ingela Schnittger, Iqbal Karimullah, Ira M Dauber, Iram Rehman, Irena Peovska Mitevska, Irene Marthe Lang, Irina Subbotina, Irma Kalibataite-Rutkauskiene, Irni Yusnida, Isabel Estela Carvajal, Isabella C Palazzo, Isabelle Hogan, Isabelle Roy, Ishba Syed, Ishita Tejani, Ivan A Naryshkin, Ivana Jankovic, Iwona Niedzwiecka, J David Knight, Jacek Kusmierek, Jackie M White, Jackie Chow, Jacob Udell, Jacqueline E Tamis-Holland, Jacqueline Fannon, Jacquelyn A Quin, Jacquelyn Do, Jaekyeong Heo, Jakub Maksym, James E Davies, James H O'Keefe Jr, James J Jang, James Cha, James Harrison, James Hirsch, James Stafford, James Tatoulis, Jamie Rankin, Jan Henzel, Jan Orga, Jana Tancredi, Janaina Oliveira, Jane Burton, Jane Eckstein, Jane Marucci, Janet P Knight, Janet Blount, Janet Halliday, Janetta Kourzenkova, Janitha Raj, Jan-Malte Sinning, Jaqueline Pozzibon, Jaroslaw Drozdz, Jaroslaw Karwowski, Jason D Glover, Jason Loh Kwok, Jason T Call, Jason Linefsky, Jassira Gomes, Jati Anumpa, Javier J Garcia, Javier Courtis, Jay Meisner, K Jayakumar, Jayne Scales, Jean E Denaro, Jean Michel Juliard, Jean Ho, Jeanette K Stansborough, Jean-Michel Juliard, Jeanne Russo, Jeannette J M Schoep, Jeet Thambyrajah, Jeff Leimberger, Jeffery A Breall, Jeffrey A Kohn, Jeffrey C Milliken, Jeffrey Anderson, Jeffrey Blume, Jeffrey Kanters, Jeffrey Lorin, Jeffrey Moses, Jelena J Stepanovic, Jelena Celutkiene, Jelena Djokic, Jelena Stojkovic, Jenne M Jose, Jenne Manchery, Jennifer A Mull, Jennifer H Czerniak, Jennifer L Stanford, Jennifer Gillis, Jennifer Horst, Jennifer Isaacs, Jennifer Langdon, Jennifer Thomson, Jennifer Tomfohr, Jennifer White, Jen-Yuan Kuo, Jeremy Rautureau, Jerome Fleg, Jessica Berg, Jessica Rodriguez, Jessica Waldron, Jhina Patro, Jia Li, Jiajia Mao, Jiamin Liu, Jian'an Wang, Jianhua Li, Jianxin Zhang, Jie Qi, Jihyun Lyo, Jill Marcus, Jim Blankenship, Jing Zhang, Jingjing Liu, Jing-Yao Fan, Jiun-Yi Li, Jiwan Pradhan, Jiyan Chen, J M Rivera Caravaca, Jo Evans, Joan Garcia Picart, Joan Hecht, Joanna Jaroch, Joanna Zalewska, Joanne Kelly, Joanne Taaffe, João Reynaldo Abbud, João V Vitola, Joaquín V Peñafiel, Jocelyne Benatar, Jody Bindeman, Joe Sabik, Joel Klitch, Johann Christopher, Johannes Aspberg, John D Friedman, John F Beltrame, John F Heitner, John Joseph Graham, John R Davies, John Doan, John Kotter, John Kurian, John Mukai, John Pownall, Jolanta Sobolewska, Jon Kobashigawa, Jonathan L Goldberg, Jonathan W Bazeley, Jonathan Byrne, Jonathan Himmelfarb, Jonathan Leipsic, Jonean Thorsen, Jorge F Trejo Gutierrez, Jorge Escobedo, Jorik Timmer, José A Ortega-Ramírez, José Antonio Marin-Neto, Jose D Salas, Jose Enrique Castillo, Jose Francisco Saraiva, José J Cuenca-Castillo, Jose L Diez, José Luis Narro Villanueva, José Luiz da Vieira, José M Flores-Palacios, Jose Ramon Gonzalez, Jose Seijas Amigo, Jose Fragata, Josep Maria Padró, Josheph F X McGarvey Jr, Joseph Hannan, Joseph Sacco, Joseph Sweeny, Joseph Wiesel, Josephine D Abraham, Joshua P Loh, Joy Burkhardt, Joyce R White, Joyce Riestenberg-Smith, Judit Sebo, Judith L Meadows, Judith Wright, Judy Mae Foltz, Judy Hung, Judy Otis, Juergen Stumpf, Jui-Peng Tsai, Julia S Dionne, Julia de Aveiro Morata, Julie Bunke, Julie Morrow, Julio César Figal, Jun Fujita, Jun Jiang, Junhua Li, Junqing Yang, Juntima Euathrongchit, Jyotsna Garg, K Manjula Rani, K Preethi, Kaatje Goetschalckx, Kai Eggers, Kamalakar Surineni, Kanae Hirase, T R Kapilamoorthy, Karen Calfas, Karen Gratrix, Karen Hallett, Karen Hultberg, Karen Nugent, Karen Petrosyan, Karen Swan, Karolina Kryczka, Karolina Wojtczak-Soska, Karolina Wojtera, Karsten Lenk, Karthik Ramasamy, Katarzyna Łuczak, Katarzyna Malinowska, Kate Pointon, Kate Robb, Katherine Martin, Kathleen Claes, Kathryn Carruthers, Kathy E Siegel, Katia Drouin, Katie Fowler-Lehman, Kavita Rawat, Kay Rowe, Keiichi Fukuda, Keith A A Fox, Ken Mahaffey, Kendra Unterbrink, Kenneth Giedd, Kerrie Van Loo, Kerry Lee, Kerstin Bonin, Kevin R Bainey, Kevin T Harley, Kevin Anstrom, Kevin Chan, Kevin Croce, Kevin Landolfo, Kevin Marzo, Keyur Patel, Khaled Abdul-Nour, Khaled Alfakih, Khaled Dajani, Khaled Ziada, Khaula Baloch, Khrystyna Kushniriuk, Kian-Keong Poh, Kim F Ireland, Kim Holland, Kimberly Ann Byrne, Kimberly E Halverson, Kimberly Elmore, Kimberly Miller-Cox, Kiran Reddy, Kirsten J Quiles, Kirsty Abercrombie, Klaus Matschke, Konrad Szymczyk, Koo Hui Chan, Kotiboinna Preethi, Kozhaya Sokhon, Krissada Meemuk, Kristian Thygesen, Kristin M Salmi, Kristin Newby, Kristina Wippler, Kristine Arges, Kristine Teoh, Krystal Etherington, Krystyna Łoboz-Grudzień, Krzysztof W Reczuch, Krzysztof Bury, Krzysztof Drzymalski, Krzysztof Kukuła, Kuo-Tzu Sung, Kurt Huber, Ladda Douangvila, Lance Sullenberger, Larissa Miranda Trama, Laszlone Matics, Laura Drew, Laura Flint, Laura Keinaite, Laura Sarti, Laurel Kolakaluri, Lawrence M Phillips, Lawrence Friedman, Lawrence Phillips, Lazar Velicki, Leah Howell, Leandro C Maranan, Leanne Cox, Ledjalem Daba, Lei Zhang, Lekshmi Dharmarajan, Leo Bockeria, Leonardo Pizzol Caetano, Leonardo Bridi, Leonid L Bershtein, Leszek Sokalski, Li Hai Yan, Li Li, Lia Nijmeijer, Lidia Sousa, Lihong Xu, Lihua Zhang, Lili Zhang, Lilia Schiavi, Lilian Mazza Barbosa, Lillian L Khor, Lina Felix-Stern, Linda L Hall, Linda M Hollenweger, Linda Arcand, Linda Davidson-Ray, Linda Schwarz, Lindsey N Sikora, Lingping Chi, Lino Patricio, Liping Zhang, Lisa Chaytor, Lisa Hatch, Lisa McCloy, Lisa Wong, Liselotte Persson, Lixin Jiang, Liz Low, Ljiljana Pupic, Loïc Bière, Lorenzo Monti, Lori Christensen, Lori Pritchard, Loriane Black, Lori-Ann Desimone, Lori-Ann Larmand, Lorraine McGregor, Louise Morby, Louise Thomson, Luc Harvey, Luciana de Pádua Baptista, Lucilla Garcia, Ludivine Eliahou, Ludmila Helmer, Luis F Smidt, Luis Bernanrdes, Luis Guzman, Luiz A Carvalho, Luyang Xiong, Lynette L Teo, Lynn M Neeson, Lynne Winstanley, M Barbara Srichai-Parsia, M Quintana Giner, M Sowjanya Reddy, M Valdés Chávarri, M Grazia Rossi, Maarten Simoons, Maayan Konigstein, Maciej Lesiak, Maciej Olsowka, Mafalda Selas, Magalie Corfias, Magdalena Madero Rovalo, Magdalena Łanocha, Magdalena Miller, Magdalena Misztal-Teodorczyk, Magdalena Rantinella, Magdy Abdelhamid, Magnolia Jimenez, Mahboob Alam, Mahevamma Mylarappa, Mahfouz El Shahawy, Mahmoud Mohamed, Mahmud Al-Bustami, Majo X Joseph, Malgorzata Frach, Małgorzta Celińska-Spodar, Malte Helm, Manas Chacko, Mandy Murphy, Manitha Vinod, Manjula Rani, Manu Dhawan, Manuela Mombelli, Marcel Weber, Marcello Galvani, Marcelo Jamus Rodrigues, Marcia F Dubin, Marcia F Werner Bayer, Marcin Szkopiak, Marco Antonio Monsalve, Marco Bizzaro Santos, Marco Magnoni, Marco Marini, Marco Sicuro, Marco Zenati, Marcos Valério Coimbra Resende, Marek Roik, Margalit Bentzvi, Margaret Gilsenan, Margaret Iraola, Margot C Quinn, Maria A Alfonso, Maria Antonieta Pereira Moraes, María Dolores Martínez-Ruíz, María Fernanda Canales, Maria Inês Caetano, Maria P Corral, Maria Pérez García, Maria Victoria Actis, Maria Aguirre, Maria Andreasson, Maria Aprile, Maria Colton, Maria Eugenia Martin, Maria Lasala, Maria Lorenzo, Maria Posada, Maria Shier, Maria Thottam, Mariana V Furtado, Mariana Yumi Okada, Marianna D A Dracoulakis, Marianne De Andrade, Mariano Rubio, Marie Essermark, Marielle Scherrer-Crosbie, Marija T Petrovic, Marija Zdravkovic, Marilyn Black, Marina Garcia, Mario J Garcia, Mariola Szulik, Marisa Orgera, Mark A de Belder, Mark Harbinson, Mark Hyun, Mark Peterson, Mark Xavier, Marlowe Mosley, Marta Capinha, Marta Marcinkiewicz-Siemion, Marta Swiderek, Martha Meyer, Martina Ceseri, Martina Tricoli, Marvin Kronenberg, Mary Williams, Mary Ann Champagne, Mary Colleen Rogge, Mary R Soltau, Mary Streif, Massimo Villella, Massoud Leesar, Matei Claudia, Mateusz Solecki, Matías Nicolás Mungo, Matthew Wall Jr, Matthew Budoff, Matthew Jezior, Matthew Luckie, Matthias Friedrich, Mauren P Haeffner, Maximilian Tscharre, Max-Paul Winter, Mayana Almeida, Mayil S Krishnam, Mayuri Patel, Meenakshi Mishra, Megan Manocchia, Meghana Kakade, Melanie J Munro, Melissa D Chaplin, Melissa LeFevre, Mervyn Andiapen, Michael A Gibson, Michael B Rubens, Michael C Turner, Michael D Shapiro, Michael W Lee, Michael Berlowitz, Michael Davidson, Michael Mack, Michael McDaniel, Michael Mumma, Michal Wlodarczyk, Michel G Khouri, Michel S Slama, Michele Rawlins, Michelle M Bonner, Michelle M Seib, Michelle Chang, Michelle Crowder, Michelle Dixon, Michelle Mayon, Michelle McEvoy, Michelle Yee, Miguel M Fernandes, Miguel Nobre Menezes, Miguel Souto Bayarri, Miguel Barrero, Mikhail T Torosoff, Milan R Dobric, Milan Dobric, Milica Nikola Dekleva, Milind Avdhoot Gadkari, Millie Gomez, Min Tun Kyaw, Miriam Brooks, Miroslav Stevo Martinovic, Mitchel B Lustre, Mohammad Tariq Vakani, Mohammad El-Hajjar, Mohammed Al-Amoodi, Mohammed Hussain, Mohammed Saleem, Moisés Blanco-Calvo, Moisés Jiménez-Santos, Mona Bhatia, Monica Rosca, Monika Laukyte, Montserrat Gracida Blanca, Montserrat Vila Perales, Mouaz H Al-Mallah, Moysés de Oliveira Filho, Mpiko Ntsekhe, Muhamed Saric, Mulei Chen, Myriam Brousseau, Myrthes Emy Takiuti, Nada Cemerlic-Adjic, Nadia Asif, Nadia Gakou, Nafisa Hussain, Nana O Katamadze, Nancy L Clapp, Nancy Aedy, Nandita Nataraj, Nanette K Wenger, Naomi Uchida, Nasrul Ismail, Natalia S Oliveira, Natalia de Carvalho Maffei, Natalie Spitzer, Natasha C Putnam, Naved Aslam, Neamat Mowafy, Neeraj Pandit, Neeraj Parakh, Nevena Garcevic, Ngaire Meadows, Nhi N Tran, Nicholas Danchin, Nicki Lakeman, Nicola Johnston, Nicolas W Shammas, Nicole Saint Vrestil, Nicole Deming, Nier Zhong, Niket Patel, Nikola N Boskovic, Nikolaos Karogiannis, Nikos Werner, Nina Johnston, Ning Zhang, Ning Zhou, Niree Hindoyan, Nirmal Kumar, Nitika Chadha, Nitish Naik, Nodira Aripova, Noloyiso Mtana, Nona A Eskelson, Noor Syamira Mokhtar, Noppon Taksaudom, Nor Asiah Basri, Nora Marchelletta, Norma Hogg, Nungshi Jungla, Nuno Ferreira, Oksana A Lubyanaya, Olga B Nikolaeva, Olga Cañavate, Olga Sobrino, Olga Walesiak, Olga Walter, Olga Zdończyk, Olivia J Lim, Olivia Anaya, Olivia Mancilla, Olivier Dubourg, Olugbenga Bello, Omar Almousalli, Omar Thompson, Oni Olurinde, Or Harel, Osama Raheem, Oscar Méndiz, Óscar Prada-Delgado, Oz Shapira, P Christian Schulze, Pachara Panpunuan, Pal Maurovich-Horvat, Pallav Garg, Paloma Moraga, Pam Singh, Pamela Julian, Pamela Ouyang, Pamela Sigel, Pamela Woodard, Panpan Zhou, Paola Emanuela Poggio, Paola Smanio, Paolo Calabro, Paramjit Jeetley, Pascal Goube, Patricia K Nguyen, Patricia Alarie, Patricia Arakelian, Patricia Arsenault, Patricia Blaise, Patricia Brito, Patricia Cowper, Patricia Endsley, Patricia Mieses, Patrick B Alexander, Patrick Donnelly, Patrick Wilmot, Patrycja Lebioda, Paul C Gordon, Paul Der Mesropian, Paul Galiwango, Paul Hauptman, Paul Kennedy, Paula Beardsley, Paula García-González, Paulo Cury Rezende, Paulo Ricardo Caramori, Pavel S Kozlov, Pedro Canas Silva, Pedro Gabriel Melo Barros E Silva, Pedro Píccaro de Oliveira, Pedro Carvalho, Pedro Modas, Pedro Rio, Peeyush Jain, Peiyu He, Peter A McCullough, Peter H Stone, Peter M Pollak, Peter Douglass, Peter Henriksen, Peter OKane, Peter Ong, Philip Jones, Philip Rogal, Philippe Généreux, Philippe Menasche, Philippe Rheault, Phoebe Goold, Pierre Gervais, Pierre Michaud, Pilar Calvillo, Ping Chai, Piotr Jakubowski, Piotr Pruszczyk, Piotr Slomka, Piyamitr Sritara, Poay-Huan Loh, Poonam Sonawane, Pouneh Samadi, Pragnesh P Parikh, Prakash Deedwania, Pranav M Patel, Praneeth Polamuri, Pratiksha Sharma, Precilia Vasquez, Preeti Kamath, Prince Thomas, Priyadarshani Arambam, Puja K Mehta, Purvez Grant, Pushpa Naik, Qi Zhong, Qian Zhao, Qiang Zhou, Qianqian Yuan, Qin Yu, Qingxian Li, Qiulan Xie, Qiutang Zeng, R J Vindhya, R James Gerlach, Rachel King, Rada Vučić, Radmila Lyubarova, Radoslaw Pracon, Raewyn Fisher, Rafael Beyar, Rafael Diaz, Rafael Selgas, Raffaele Bugiardini, Raffaele Fanelli, Raisa Kavalakkat, V S Rajalekshmi, Rajat S Barua, Rajeev Menon, Rajesh Gopalan Nair, Rajesh Francis, Rajiv Narang, Rakesh Yadav, Ralph Alan Huston, T Ramakrishnan, Ramesh de Silva, Rami El Mahmoud, Ramiro Carvalho, Ramon de Jesús-Pérez, Ramona Stevens, Ran Leng, Ranjan Kachru, Ranjit Kumar Nath, Raquel Sanchez, Raven R Dwyer, Raven Lee, Ray Wyman, Raymond C Wong, Raymond W Little, Raymundo Ocaranza Sanchez, Rebecca J Wimmer, Rebecca Bariciano, Rebecca Otis, Rebekah R Herrmann, Reem Yunis, Reinette Hampson, Renato Abdala Karam, Renee C Hessian, Renee Kaneshiro, Reshma Ravindran, Reto Andreas Gamma, Reyna Bhandari, Reza Arsanjani, Ricardo L Lopes, Ricardo Mendes Oliveira, Ricardo Costa, Richa Bhatt, Richard F Davies, Richard H J Trimlett, Richard Goldweit, Rik Hermanides, Rine Nakanishi, Rinu R Sidh, Risha Patel, Rita Coram, Rizwan A Siddiqui, Rob S Beanlands, Robert J Hamburger, Robert K Riezebos, Robert M Donnino, Robert Bojar, Robert Chilton, Robert Guyton, Robert Henderson, Robert Kornberg, Robert Leber, Robert Mao, Robert Stenberg, Roberta P Santos, Roberto René Favaloro, Roberto Amati, Rodolfo G S D Lima, Rodrigo J Cerci, Rogerio Tumelero, Rohit Tandon, Roma Tewari, Romalisa Miranda-Peats, Ron Wald, Ronald A Mastouri, Ronald G Morford, Ronald G Schwartz, Ronald P Pedalino, Rongrong Hu, Ronnell A Hansen, Ronny A Cohen, Rory Hachamovitch, Rosa Homem, Rosa Sandonato, Rosane Laimer, Rosann Gans, Roxanne Yost, Roy Mathew, Rubén Baleón-Espinosa, Ruben Ramos, Rubine Gevorgyan, Rui Ferreira, Rui Jing, Ruth Pérez-Fernández, S K Dwivedi, S Ramakrishnan, Saadat Khan, Sabahat Bokhari, Sabu Thomas, Sadath Lubna, Sajeeda Parveen Khan, Sajeev Chakanalil Govindan, Saket Girotra, Saleem Kassam, Sallie Canada, Salvador Cruz-Flores, Samaa Mohamed, Samantha Ly, Sameh El Kaffas, Samia Massalha, Sampoornima Setty, Samuel Nwosu, Sandeep Seth, Sandeep Singh, Sander R Niehe, Sandra M Rivest, Sandra S Zier, Sandra Ahoud, Sandy Carr, Sanjay Ganapathi, Sanjay Shetty, Sanjeev Sharma, Santa Jimenez, Santhosh Satheesh, Santiago A Garcia, Sara Fernandez, Sara Karlsson, Sara Salkind, Sara Temiyasathit, Sarah Medina Rodriguez, Sarah Beaudry, Sarah Hadjih, Sarah Williams, Sarah Zahrani, Sarju Ralhan, Sasa Hinic, Sasko Kedev, Satinder Singh, Satoshi Yasuda, Satvic Cholenahally Manjunath, Sau Lee, Scott M Kaczkowski, Scott Kinlay, Sean W Hayes, Sebastian Sobczak, Senait Asier, Sergey A Sayganov, Seth I Sokol, Shaheen Pandie, Shaiful Azmi Yahaya, Shamir Mehta, Shao-Ping Nie, Sharad Chandra, Sharder Islam, Sharon Tai, Sheetal Rupesh Karwa, Sheri Ussery, Sheromani Bajaj, Sherron C Crook, Shigeyuki Nishimura, Shintaro Nakano, Shirin Heydari, Shiv Kumar Choudhary, Shivali Patel, Shobana Ganesan, Shruti Pandey, Shuyang Zhang, Shweta Hande, Siddharth Gadage, Sik-Yin V Tan, Silvia Zottis Poletti, Silvia Riera, Silvia Valbuena, Simon Walsh, Simona Maspoli, Simone Savaris, Si-Ting Feng, So Yang Cho, Solomon Yakubov, Songlin Zhu, Songtao Wang, Sonia Guerrero, Sonika Gupta, Sonja Salinger Martinovic, Sonya Brons, Sorin Brener, Sothinathan Gurunathan, Souheil Saba, Soundarya Nayak, Sowjanya Reddy, Srinivasa Potluri, Sriram Sudarshan, Srun Kuanprasert, Stacie Van Oosterhout, Stamatios Lerakis, Stanley E Cobos, Stefan C Bertog, Stefan M Simović, Stefan Weikl, Stefano Di Marco, Stefano Provasoli, Stephanie A Tirado, Stephanie C Boer, Stephanie M Lane, Stephanie Ferket, Stephanie Kelly, Stephanie Wasmiller, Stephen H McKellar, Stephen P Hoole, Stephen Fremes, Stephen Preston, Steve Leung, Steven A Fein, Steven J Lindsay, Steven P Sedlis, Steven Giovannone, Steven Michael, Steven Weitz, Stijn van Vugt, Subhash Banerjee, Sudhir Naik, Suellen Hosino, Sukie Desire, Sukit Yamwong, Suku T Thambar, Sulagna Mookherjee, Suman Singh, Sundeep Mishra, Sunil Kumar Verma, Supap Kulthawong, Supatchara Khwakhong, Surendra Naik, Suresh Babu, Surin Woragidpoonpol, Suryaprakash Narayanappa, Susan Derbyshire, Susan Gent, Susan Mathus, Susan Milbrandt, Susan Moore, Susan Regan, Susan Stinson, Susan Webber, Susana Silva, Susanna Stevens, Susanne Gruensfelder, Suthara Aramcharoen, Suvarna Kolhe, Suzana Tavares, Suzanne Arnold, Suzanne Welsh, Svetlana Apostolovic, Swapna Kunhunny, Ta-Chuan Hung, Taissa Zappernick, Tali Sharir, Talita Silva, Tamara Colaiácovo Soares, Tapan Umesh Pillay, Tarun K Mittal, Tatiana Trifonova, Tauane Bello Duarte, Tauqir Huk, Téodora Dutoiu, Terrance Chua, Terry Weyand, Thabitha Charles, Theodoros Kofidis, Theresa McCreary, Thierry Lefevre, Thippeekaa Arumairajah, Thitipong Tepsuwan, Thomas J Mulhearn, Thomas M Meyer, Thomas P Rocco, Thomas R Downes, Thomas Crain, Thomas Haldis, Thomas Mathew, Thomas Redick, Thounaojam Indira Devi, Thuraia Nageh, Tia Cauthren, Tiago Silva, Tiffany Little, Tijana Andric, Tina Harding, Titus Lau, Tiziana Formisano, Tiziano Moccetti, Tomasz Ciurus, Tomasz Mazurek, Tomasz Tarchalski, Toshiyuki Nagai, Tri Tran, Tricia Youn, Trish Tucker, Trudie Milner, Tuhina Bose, Tushar Kotecha, Udo Sechtem, Uma S Valeti, Umberto Cucchini, Umesh Badami, Upendra Kaul, V K Bahl, V S Narain, Valentina Casali, Valeria Godoy, Valerie Robesyn, Vamshi P Priya, Vandana Yadav, Vera McKinney, Veronica De Lenges, Veronica Tinnirello, Vicente Miro, Victor Navarro, Victoria Gumerova, Victoria Hernandez, Vidya Seeratan, Vijay Kumar, Vikentiy Y Kozulin, Viktoria Bulkley, Vilmar Veiga Jr, Vincent Setang, C P Vineeth, Virginai Pubull Nuñez, Virginia Fernández-Figares, Vitor Gomes, Viviana Gabriel, Viviane Dos Santos, Viviane Almeida, Vlad A Iliescu, Vladan Mudrenovic, Vladimir Dzavik, Vojislav L Giga, Walter Enrique Mogrovejo, Wan Xian Chan, Wanda C Marfori, Wanda Parker, Warangkana Mekara, Wassim Nona, Wayne Old, Wayne Pennachi, Weerachai Nawarawong, Wei Chen, Wei Su, Weibing Xing, Wei-Ren Lan, Wenda Crawford, Wendy L Stewart, Wendy Drewes, Wenhua Lin, William B Abernethy, William D Salerno, William F Fearon, William Vergoni, William Weintraub, Winnie C Sia, Wlodzimierz J Musial, Xacobe Flores-Ríos, Xavier Garcia-Moll Marimon, Xi Su, Xiang Ma, Xiangqiong Gu, Xiao Wang, Xiaomei Li, Xiaowei Yao, Xin Fu, Xin Su, Xin Zeng, Xinchun Yang, Xiuhong Li, Xuehua Fang, Xutong Wang, Yaming Geng, Yan Yan, Yanek Pépin-Dubois, Yanfu Wang, Yang Wang, Yanmeng Tian, Yaping Huang, Yechen Han, Yesenia Zambrano, Yi-Hsuan Yang, Ying Tung Sia, Yining Yang, Yitong Ma, Yolayfi Peralta, Yongjian Wu, Yu Kunwu, Yu Zhao, Yudong Peng, Yueh-Hung Lin, Yulan Zhao, Yumei Dong, Yunhai Zhao, Yutthaphan Wannasopha, Yvonne Taul, Zakir Sahul, Zalina Kudzoeva, Zbigniew Kalarus, Zeljko Z Markovic, Zhen Huang, Zheng Ji, Zhenyu Liu, Zhou Yue, Zhulin Zhang, Zhuxi Li, Zile Singh Meharwal, Ziliang Bai, Zixiang Yu, Zohra Huda, Zoltan Davidovits

Subjects
Male, Cardiac Catheterization, Computed Tomography Angiography, medicine.medical_treatment, Myocardial Ischemia, Coronary Disease, Coronary Artery Disease, Kaplan-Meier Estimate, 030204 cardiovascular system & hematology, Coronary Angiography, ISCHEMIA Research Group, law.invention, Angina, Coronary artery disease, 0302 clinical medicine, Randomized controlled trial, law, Cardiovascular Disease, Myocardial Revascularization, 030212 general & internal medicine, Coronary Artery Bypass, 11 Medical and Health Sciences, Cardiac catheterization, General Medicine, Middle Aged, humanities, Cardiovascular Diseases, Cardiology, Female, Human, medicine.medical_specialty, Ischemia, Article, 03 medical and health sciences, Geriatric cardiology, Percutaneous Coronary Intervention, General & Internal Medicine, Internal medicine, medicine, Humans, Angina, Unstable, Aged, business.industry, Coronary Artery Bypa, Percutaneous coronary intervention, Bayes Theorem, medicine.disease, Heart failure, Quality of Life, business
Abstract

BACKGROUND: Among patients with stable coronary disease and moderate or severe ischemia, whether clinical outcomes are better in those who receive an invasive intervention plus medical therapy than in those who receive medical therapy alone is uncertain. METHODS: We randomly assigned 5179 patients with moderate or severe ischemia to an initial invasive strategy (angiography and revascularization when feasible) and medical therapy or to an initial conservative strategy of medical therapy alone and angiography if medical therapy failed. The primary outcome was a composite of death from cardiovascular causes, myocardial infarction, or hospitalization for unstable angina, heart failure, or resuscitated cardiac arrest. A key secondary outcome was death from cardiovascular causes or myocardial infarction. RESULTS: Over a median of 3.2 years, 318 primary outcome events occurred in the invasive-strategy group and 352 occurred in the conservative-strategy group. At 6 months, the cumulative event rate was 5.3% in the invasive-strategy group and 3.4% in the conservative-strategy group (difference, 1.9 percentage points; 95% confidence interval [CI], 0.8 to 3.0); at 5 years, the cumulative event rate was 16.4% and 18.2%, respectively (difference, -1.8 percentage points; 95% CI, -4.7 to 1.0). Results were similar with respect to the key secondary outcome. The incidence of the primary outcome was sensitive to the definition of myocardial infarction; a secondary analysis yielded more procedural myocardial infarctions of uncertain clinical importance. There were 145 deaths in the invasive-strategy group and 144 deaths in the conservative-strategy group (hazard ratio, 1.05; 95% CI, 0.83 to 1.32). CONCLUSIONS: Among patients with stable coronary disease and moderate or severe ischemia, we did not find evidence that an initial invasive strategy, as compared with an initial conservative strategy, reduced the risk of ischemic cardiovascular events or death from any cause over a median of 3.2 years. The trial findings were sensitive to the definition of myocardial infarction that was used. (Funded by the National Heart, Lung, and Blood Institute and others; ISCHEMIA ClinicalTrials.gov number, NCT01471522.).

Published
2020
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47. Precision of MRI radiomics features in the liver and hepatocellular carcinoma

Author

Bachir Taouli, Daniel Stocker, Stefanie J. Hectors, Paul Kennedy, Guillermo Carbonell, Olivier Gevaert, Maria El Homsi, Ammar Kirmani, Sara Lewis, Daniela Said, Pritam Mukherjee, and Octavia Bane

Subjects
Reproducibility, medicine.medical_specialty, Intraclass correlation, business.industry, Coefficient of variation, General Medicine, Repeatability, medicine.disease, Concordance correlation coefficient, Hepatocellular carcinoma, medicine, Effective diffusion coefficient, Radiology, Nuclear Medicine and imaging, Radiology, business, Neuroradiology
Abstract

To assess the precision of MRI radiomics features in hepatocellular carcinoma (HCC) tumors and liver parenchyma. The study population consisted of 55 patients, including 16 with untreated HCCs, who underwent two repeat contrast-enhanced abdominal MRI exams within 1 month to evaluate: (1) test–retest repeatability using the same MRI system (n = 28, 10 HCCs); (2) inter-platform reproducibility between different MRI systems (n = 27, 6 HCCs); (3) inter-observer reproducibility (n = 16, 16 HCCs). Shape and 1st- and 2nd-order radiomics features were quantified on pre-contrast T1-weighted imaging (WI), T1WI portal venous phase (pvp), T2WI, and ADC (apparent diffusion coefficient), on liver regions of interest (ROIs) and HCC volumes of interest (VOIs). Precision was assessed by calculating intraclass correlation coefficient (ICC), concordance correlation coefficient (CCC), and coefficient of variation (CV). There was moderate to excellent test–retest repeatability of shape and 1st- and 2nd-order features for all sequences in HCCs (ICC: 0.53–0.99; CV: 3–29%), and moderate to good test–retest repeatability of 1st- and 2nd-order features for T1WI sequences, and 2nd-order features for T2WI in the liver (ICC: 0.53–0.73; CV: 12–19%). There was poor inter-platform reproducibility for all features and sequences, except for shape and 1st-order features on T1WI in HCCs (CCC: 0.58–0.99; CV: 3–15%). Good to excellent inter-observer reproducibility was found for all features and sequences in HCCs (CCC: 0.80–0.99; CV: 4–15%) and moderate to good for liver (CCC: 0.45–0.86; CV: 6–25%). MRI radiomics features have acceptable repeatability in the liver and HCC when using the same MRI system and across readers but have low reproducibility across MR systems, except for shape and 1st-order features on T1WI. Data must be interpreted with caution when performing multiplatform radiomics studies. • MRI radiomics features have acceptable repeatability when using the same MRI system but less reproducible when using different MRI platforms. • MRI radiomics features extracted from T1 weighted-imaging show greater stability across exams than T2 weighted-imaging and ADC. • Inter-observer reproducibility of MRI radiomics features was found to be good in HCC tumors and acceptable in liver parenchyma.

Published
2021
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49. MR elastography outperforms shear wave elastography for the diagnosis of clinically significant portal hypertension

Author

Paul Kennedy, Daniel Stocker, Guillermo Carbonell, Daniela Said, Octavia Bane, Stefanie Hectors, Ghadi Abboud, Jordan Cuevas, Bradley D. Bolster, Scott L. Friedman, Sara Lewis, Thomas Schiano, Dipankar Bhattacharya, Aaron Fischman, Swan Thung, Bachir Taouli, University of Zurich, and Taouli, Bachir

Subjects
Adult, Liver Cirrhosis, 10042 Clinic for Diagnostic and Interventional Radiology, 610 Medicine & health, General Medicine, Middle Aged, Portal Pressure, Article, Liver, Hypertension, Portal, 2741 Radiology, Nuclear Medicine and Imaging, Humans, Elasticity Imaging Techniques, Radiology, Nuclear Medicine and imaging, Prospective Studies, Aged
Abstract

Portal hypertension (PH) is associated with complications such as ascites and esophageal varices and is typically diagnosed through invasive hepatic venous pressure gradient (HVPG) measurement, which is not widely available. In this study, we aim to assess the diagnostic performance of 2D/3D MR elastography (MRE) and shear wave elastography (SWE) measures of liver and spleen stiffness (LS and SS) and spleen volume, to noninvasively diagnose clinically significant portal hypertension (CSPH) using HVPG measurement as the reference.In this prospective study, patients with liver disease underwent 2D/3D MRE and SWE of the liver and spleen, as well as HVPG measurement. The correlation between MRE/SWE measures of LS/SS and spleen volume with HVPG was assessed. ROC analysis was used to determine the utility of MRE, SWE, and spleen volume for diagnosing CSPH.Thirty-six patients (M/F 22/14, mean age 55 ± 14 years) were included. Of the evaluated parameters, 3D MRE SS had the strongest correlation with HVPG (r = 0.686, p0.001), followed by 2D MRE SS (r = 0.476, p = 0.004). 3D MRE SS displayed the best performance for diagnosis of CSPH (AUC = 0.911) followed by 2D MRE SS (AUC = 0.845) and 3D MRE LS (AUC = 0.804). SWE SS showed poor performance for diagnosis of CSPH (AUC = 0.583) while spleen volume was a fair predictor (AUC = 0.738). 3D MRE SS was significantly superior to SWE LS/SS (p ≤ 0.021) for the diagnosis of CSPH.SS measured with 3D MRE outperforms SWE for the diagnosis of CSPH. SS appears to be a useful biomarker for assessing PH severity. These results need further validation.• Spleen stiffness measured with 2D and 3D MR elastography correlates significantly with hepatic venous pressure gradient measurement. • Spleen stiffness measured with 3D MR elastography demonstrates excellent performance for the diagnosis of clinically significant portal hypertension (AUC 0.911). • Spleen stiffness measured with 3D MR elastography outperforms liver and spleen stiffness measured with shear wave elastography for diagnosis of clinically significant portal hypertension.

Published
2022

50. Synthesis of High-Molecular-Weight and Strength Polyisobutylene-Based Polyurethane and Its Use for the Development of a Synthetic Heart Valve

Author

Tejal Deodhar, Nihan Nugay, Turgut Nugay, Ruhi Patel, Geoff Moggridge, and Joseph Paul Kennedy

Subjects
Polymers and Plastics, Organic Chemistry, Materials Chemistry
Abstract

Under optimized synthesis conditions, for the first time, polyisobutylene-based polyurethane (PIB-PU) is prepared with 70% PIB soft segment (i.e., a bioinert and calcification-resistant PU) with M

Published
2022

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