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1. Parsimonious immune-response endotypes and global outcome in patients with traumatic brain injuryResearch in context

2. Stratified analyses refine association between TLR7 rare variants and severe COVID-19

3. Association of early blood-based biomarkers and six-month functional outcomes in conventional severity categories of traumatic brain injury: capturing the continuous spectrum of injuryResearch in context

4. Multimorbidity-associated emergency hospital admissions: a 'screen and link' strategy to improve outcomes for high-risk patients in sub-Saharan Africa: a prospective multicentre cohort study protocol [version 2; peer review: 1 approved, 2 approved with reservations]

5. Causes, outcomes and diagnosis of acute breathlessness hospital admissions in Malawi: protocol for a multicentre prospective cohort study [version 1; peer review: 2 approved]

6. Multimorbidity-associated emergency hospital admissions: a 'screen and link' strategy to improve outcomes for high-risk patients in sub-Saharan Africa: a prospective multicentre cohort study protocol [version 1; peer review: 1 approved, 2 approved with reservations]

7. Alpha 2 agonists for sedation to produce better outcomes from critical illness (A2B Trial): protocol for a multicentre phase 3 pragmatic clinical and cost-effectiveness randomised trial in the UK

8. Healthcare resilience: a meta-narrative systematic review and synthesis of reviews

9. Comparative effectiveness of decompressive craniectomy versus craniotomy for traumatic acute subdural hematoma (CENTER-TBI): an observational cohort studyResearch in context

10. The accuracy of pulse oximetry in measuring oxygen saturation by levels of skin pigmentation: a systematic review and meta-analysis

11. Composition and diversity analysis of the lung microbiome in patients with suspected ventilator-associated pneumonia

12. ClinCirc identifies alterations of the circadian peripheral oscillator in critical care patients

13. Role of immunosuppression in an antibiotic stewardship intervention and its association with clinical outcomes and antibiotic use: protocol for an observational study (RISC-sepsis)

14. Concomitant spine trauma in patients with traumatic brain injury: Patient characteristics and outcomes

15. Implementation of corticosteroids in treatment of COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK: prospective, cohort study

16. The effectiveness of frequent antibiotic use in reducing the risk of infection-related hospital admissions: results from two large population-based cohorts

17. Using statistics and mathematical modelling to understand infectious disease outbreaks: COVID-19 as an example

18. Neurocognitive correlates of probable posttraumatic stress disorder following traumatic brain injury

19. The impact of viral mutations on recognition by SARS-CoV-2 specific T cells

20. Vitamin D insufficiency in COVID-19 and influenza A, and critical illness survivors: a cross-sectional study

21. Procalcitonin Evaluation of Antibiotic Use in COVID-19 Hospitalised Patients (PEACH): Protocol for a Retrospective Observational Study

22. RECOVERY- Respiratory Support: Respiratory Strategies for patients with suspected or proven COVID-19 respiratory failure; Continuous Positive Airway Pressure, High-flow Nasal Oxygen, and standard care: A structured summary of a study protocol for a randomised controlled trial

23. Mucoactive agent use in adult UK Critical Care Units: a survey of health care professionals’ perception, pharmacists’ description of practice, and point prevalence of mucoactive use in invasively mechanically ventilated patients

24. Guidelines on the management of acute respiratory distress syndrome

25. Use of Procalcitonin during the First Wave of COVID-19 in the Acute NHS Hospitals: A Retrospective Observational Study

26. Sepsis: the LightCycler SeptiFast Test MGRADE®, SepsiTest™ and IRIDICA BAC BSI assay for rapidly identifying bloodstream bacteria and fungi – a systematic review and economic evaluation

27. Rapid detection of health-care-associated bloodstream infection in critical care using multipathogen real-time polymerase chain reaction technology: a diagnostic accuracy study and systematic review

28. The clinical diagnostic accuracy of rapid detection of healthcare-associated bloodstream infection in intensive care using multipathogen real-time PCR technology

29. Higher dose corticosteroids in patients admitted to hospital with COVID-19 who are hypoxic but not requiring ventilatory support (RECOVERY)

31. Alternative pathway dysregulation in tissues drives sustained complement activation and predicts outcome across the disease course in COVID‐19

32. Tailoring Multi-Dimensional Outcomes to Level of Functional Recovery after Traumatic Brain Injury

33. Vibrational Spectroscopy for the Triage of Traumatic Brain Injury Computed Tomography Priority and Hospital Admissions

34. Microbial Volatiles as Diagnostic Biomarkers of Bacterial Lung Infection in Mechanically Ventilated Patients

35. Role of immunosuppression in an antibiotic stewardship intervention and its association with clinical outcomes and antibiotic use: protocol for an observational study (RISC-sepsis)

36. SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination

37. Fluid balance and outcome in critically ill patients with traumatic brain injury (CENTER-TBI and OzENTER-TBI)

39. Concomitant spine trauma in patients with traumatic brain injury: Patient characteristics and outcomes

40. Healthcare resilience - A meta-narrative systematic review and synthesis

41. Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis

42. Surgery versus conservative treatment for traumatic acute subdural haematoma: a prospective, multicentre, observational, comparative effectiveness study

43. Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial

44. biomArker-guided Duration of Antibiotic treatment in hospitalised Patients with suspecTed Sepsis (ADAPT-Sepsis): A protocol for a multicentre randomised controlled trial

45. The multidisciplinary team perspectives on agitation management in critical care: A qualitative study

46. Procalcitonin is not a reliable biomarker of bacterial coinfection in people with coronavirus disease 2019 undergoing microbiological investigation at the time of hospital admission

47. A genome-wide association study of outcome from traumatic brain injury

48. Namilumab or infliximab compared with standard of care in hospitalised patients with COVID-19 (CATALYST): a randomised, multicentre, multi-arm, multistage, open-label, adaptive, phase 2, proof-of-concept trial

49. Co-enrolment to UK Critical Care Studies – A 2019 update

50. Predictors of Access to Rehabilitation in the Year Following Traumatic Brain Injury

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