1. The role of surgery for anaplastic thyroid carcinoma in the era of targeted therapeutics: A scoping review
- Author
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Eoin F. Cleere, Thomas J. Crotty, Justin M. Hintze, Conall W. R. Fitzgerald, John Kinsella, Paul Lennon, Conrad V. I. Timon, Robbie S. R. Woods, Neville P. Shine, and James P. O'Neill
- Subjects
anaplastic ,surgery ,targeted therapy ,thyroid ,unresectable ,Otorhinolaryngology ,RF1-547 ,Surgery ,RD1-811 - Abstract
Abstract Background Questions exist regarding patient selection for surgery in anaplastic thyroid carcinoma (ATC), particularly with the advent of neoadjuvant‐targeted therapeutics. The present scoping review sought to evaluate what extent of surgical resection should be performed in ATC. Methods A scoping review was carried out in accordance with Joanna Briggs Institute and the preferred reporting items for systematic reviews and meta‐analyses extension for scoping reviews (PRISMA‐ScR) protocols. Included studies were required to provide clear description of the surgery performed for ATC. Results The final search identified 6901 articles. Ultimately only 15 articles including 1484 patients met inclusion criteria. A total of 765 patients (51.5%) underwent attempted curative intent surgery. The approach to resection of adjacent tissues varied between studies. Eight studies considered laryngeal ± pharyngeal resection (8/15, 53.3%), eight studies (53.3%) considered tracheal resection and again eight studies (53.3%) considered esophageal resection. More extensive resections increased morbidity without improving overall survival (OS) (
- Published
- 2023
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