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3. Diagnosis-Specific Thresholds of the Minimal Clinically Important Difference and Patient Acceptable Symptom State for KOOS After Total Knee Arthroplasty

Author

Emara, Ahmed K., Pasqualini, Ignacio, Klika, Alison K., Orr, Melissa N., Rullán, Pedro J., Piuzzi, Nicolas S., Murray, Trevor G., Molloy, Robert M., Stearns, Kim L., Krebs, Viktor E., Bloomfield, Michael R., Higuera, Carlos A., McLaughlin, John P., Deren, Matthew E., Surace, Peter, Barsoum, Wael K., Mesko, Nathan W., Patel, Preetesh D., Brooks, Peter, Muschler, George F., Nickodem, Robert J., Nystrom, Lukas M., Patterson, Brendan M., Kamath, Atul F., Mont, Michael A., Suarez, Juan C., Kolczun, Michael W., Krahe, David H., Sabo, Frank M., Masin, Richard R., Nemeth, Victor A., Lietman, Steven A., Sziraky, Patrick E., Joyce, Michael J., Scarcella, Joseph B., Grieco, Preston, Manriques-Succar, Jorge, Nystrom, Lukas, Hampton, Robert, Pierce, Bradley A., and Grits, Daniel

Published
2024
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10. Demographic and Socioeconomic Determinants Are Associated with Poor Preoperative Patient-Reported Pain and Function in Primary TKA: A Cohort Study of 14,079 Patients

Author

Vega, Jose, Emara, Ahmed K., Orr, Melissa, Klika, Alison K., Piuzzi, Nicolas S., Suarez, Juan C., George, Joseph W., Hampton, Robert J., Parker, Richard D., Muschler, George F., Riesgo, Aldo M., Leo, Brian M., Serna, Alfred, Mont, Michael A., McCoy, Brett W., Sabo, Frank M., Masin, Richard R., McLaughlin, John P., Patterson, Brendan M., Krahe, David H., Nystrom, Lukas M., Nemeth, Victor A., Sziraky, Patrick E., Matko, Andrew J., Brooks, Peter J., Patel, Preetesh D., Molloy, Robert M., Murray, Trevor G., Stearns, Kim L., Krebs, Viktor E., Bloomfield, Michael R., Kolczun, Michael W., Nickodem, Robert J., Schaffer, Jonathan L., Greene, Kenneth A., Higuera, Carlos A., Mesko, Nathan W., and Strnad, Gregory J.

Published
2023
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14. The Impact of Surgeon Variability on Patient-Reported Outcome Measures, Length of Stay, Discharge Disposition, and 90-Day Readmission in TKA

Author

Sinclair, SaTia T., Klika, Alison K., Jin, Yuxuan, Higuera, Carlos A., Piuzzi, Nicolas S., Brooks, Peter J., Muschler, George F., Hampton, Robert J., Greene, Kenneth A., George, Joseph W., Parker, Richard D., Kolczun, Michael W., Masin, Richard R., Serna, Alfred, Krahe, David H., Sabo, Frank M., McLaughlin, John P., Patterson, Brendan M., McCoy, Brett W., Nemeth, Victor A., Nystrom, Lukas M., Matko, Andrew J., Sziraky, Patrick E., Scarcella, Joseph B., Joyce, Michael J., Pierce, Bradley A., Lietman, Steven A., Barsoum, Wael K., Riesgo, Aldo M., Suarez, Juan C., Mont, Michael A., Strnad, Gregory J., Molloy, Robert M., Patel, Preetesh D., Schaffer, Jonathan L., Murray, Trevor G., Stearns, Kim L., Krebs, Viktor E., Nickodem, Robert J., Bloomfield, Michael R., Mesko, Nathan W., and Spindler, Kurt P.

Published
2022
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16. Understanding the Main Predictors of Length of Stay After Total Hip Arthroplasty: Patient-Related or Procedure-Related Risk Factors?

Author

Girbino, Kelsey L., Klika, Alison K., Barsoum, Wael K., Bloomfield, Michael R., Briskin, Isaac N., Brooks, Peter J., Higuera, Carlos A., Kamath, Atul F., Krebs, Viktor E., McLaughlin, John P., Mesko, Nathan W., Molloy, Robert M., Mont, Michael A., Murray, Trevor G., Muschler, George F., Nickodem, Robert J., Nystrom, Lukas M., Patel, Preetesh D., Patterson, Brendan M., Riesgo, Aldo M., Stearns, Kim L., Strnad, Gregory J., Suarez, Juan C., and Piuzzi, Nicolas S.

Published
2021
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18. GUEST EDITORIAL. What's New in Orthopaedic Trauma.

Author

Chen, Andrew T. and Patterson, Brendan M.

Abstract

The authors explore updates on studies in orthopaedic trauma. Topics discussed include a systemic review and meta-analysis of conservative treatment compared to surgical treatment of displaced fractures, a meta-analysis of randomized controlled trials (RCT) comparing functional bracing with operative fixation techniques, and a meta-analysis of RCTs comparing operative and nonoperative treatments of distal radial fractures.

Published
2024
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19. Rate of incidental findings on routine preoperative computed tomography for shoulder arthroplasty.

Author

Meeker, Daniel G., Bozoghlian, Maria F., Hartog, Taylor Den, Corlette, Jill, Nepola, James V., and Patterson, Brendan M.

Subjects
SHOULDER surgery, ARTHROPLASTY, COMPUTED tomography
Abstract

Background: Incidental findings are commonly noted in advanced imaging studies. Few data exist regarding the rate of incidental findings on computed tomography (CT) for preoperative shoulder arthroplasty planning. This study aims to identify the incidence of these findings and the rate at which they warrant further work-up to help guide orthopedic surgeons in counseling patients. Methods: A retrospective review was performed to identify patients with available preoperative shoulder CT who subsequently underwent shoulder arthroplasty procedures at a single institution between 2015 and 2021. Data including age, sex, and smoking status were obtained. Radiology reports for CTs were reviewed for incidental findings and categorized based on location, tissue type, and/or body system. The rate of incidental findings and the rate at which further follow-up was recommended by the radiologist were determined. Results: A total of 617 patients was identified. There were 173 incidental findings noted in 146 of these patients (23.7%). Findings ranged from pulmonary (59%), skin/soft tissue (16%), thyroid (13%), vascular (9%), spinal (2%), and abdominal (1%) areas. Of the pulmonary findings, 50% were pulmonary nodules and 47% were granulomatous disease. Overall, the final radiology report recommended further follow-up for 50% of the patients with incidental findings. Conclusions: Incidental findings are relatively common in preoperative CTs obtained for shoulder arthroplasty, occurring in nearly one-quarter of patients. Most of these findings are pulmonary in nature. Overall, half of the patients with incidental findings were recommended for further follow-up. These results establish population data to guide orthopedic surgeons in patient counseling. Level of evidence: III. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Periostin Is a Biomarker for Anterior Shoulder Instability: Proteomic Analysis of Synovial Fluid.

Author

Galvin, Joseph W., Milam, Rachel J., Patterson, Brendan M., Nepola, James V., Buckwalter IV, Joseph A., Wolf, Brian R., Say, Felicity M., Free, Katherine E., and Yohannes, Elizabeth

Subjects
T-test (Statistics), SYNOVIAL fluid, KRUSKAL-Wallis Test, FISHER exact test, PERIOSTIN, CHI-squared test, LONGITUDINAL method, PROTEOMICS, RESEARCH methodology, WESTERN immunoblotting, MASS spectrometry, ANALYSIS of variance, SHOULDER injuries, DATA analysis software, BIOMARKERS, JOINT instability
Abstract

Background: The incremental biological changes in the synovial microenvironment of the shoulder in acute and chronic instability that may contribute to joint degeneration are poorly understood. Proteomic analysis of synovial fluid in patients with shoulder instability may improve our understanding of proteins that are shed into shoulder synovial fluid after an injury. Hypothesis: Injury-specific factors such as the direction of instability and the severity of glenoid and humeral bone loss are associated with the proteome of synovial fluid in patients with shoulder instability. Study Design: Descriptive laboratory study. Methods: Synovial fluid lavage samples were compared between patients with anterior (n = 12) and posterior (n = 8) instability and those without instability (n = 5). Synovial proteins were identified with liquid chromatography–tandem mass spectrometry. Orthogonal validation of protein targets found to be significant on tandem mass spectrometry was performed in a separate set of prospective patients with Western blotting. Data were processed and analyzed, and P values were adjusted with the Benjamini-Hochberg method for multiple comparisons. Results: A total of 25 patients were included. Tandem mass spectrometry identified 720 protein groups in synovial fluid of patients with shoulder instability. There were 4 synovial proteins that were significantly expressed in patients with anterior instability relative to posterior instability: periostin (POSTN) (adjusted P value =.03; log fold change [logFc] = 4.7), transforming growth factor beta–induced protein ig-h3 (adjusted P value =.05; logFc = 1.7), collagen type VI alpha-3 chain (adjusted P value =.04; logFc = 2.6), and coagulation factor V (adjusted P value =.04; logFc = −3.3). Among these targets, POSTN showed a moderate correlation with the Hill-Sachs lesion size (r = 0.7). Prospective validation with Western blotting confirmed a significantly higher level of POSTN in synovial fluid of patients with anterior instability (P =.00025; logFc = 5.1). Conclusion: Proteomic analysis enriched our understanding of proteins that were secreted into shoulder synovial fluid of patients with shoulder instability. The identification of POSTN, a proinflammatory catabolic protein involved with tissue remodeling and repair, as a significant target in anterior shoulder instability is a novel finding. Therefore, further study is warranted to determine the role that POSTN may play in the progression of bone loss and posttraumatic osteoarthritis. Clinical Relevance: Proteomic analysis of synovial fluid in patients with shoulder instability improved our understanding of this abnormality after an injury. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Increasing Awareness of Complications of Nerve Injury Following Shoulder Surgery: Preventing Delays in Referral and Treatment.

Author

Patterson, Brendan M., Reed, Evelyn R., Hill, Elspeth, Buckwalter V, Joseph A., Bozoghlian, Maria F., and Mackinnon, Susan E.

Abstract

Background: Nerve injuries remain a challenging complication after shoulder surgery. While most resolve spontaneously, some require surgical intervention. This study describes the characteristics of patients sustaining nerve injuries following shoulder surgery, evaluates referral patterns to nerve surgeons, and characterizes nerve surgeries performed and their outcomes. Increased awareness of these injuries allows patients and providers to be better informed regarding the appropriate management when these complications occur. Methods: A retrospective review of referrals with nerve injuries following shoulder surgery between 2007 and 2015 was performed. The final analysis included 65 patients. Data reviewed included demographics, procedure and anesthesia type, and diagnosis of nerve injury. Time to referral to nerve surgeon and proportional changes in the Disabilities of the Arm, Shoulder, and Hand (DASH) scores were determined. Outcomes were categorized as failed, partially successful, and successful based on final follow-up. Results: Patients were referred following arthroscopic shoulder surgeries (35.4%), shoulder arthroplasties (24.6%), open shoulder procedures (21.5%), and combined open and arthroscopic procedures (18.5%). The mean time to referral was 7.6 months. Nerve injuries involved brachial plexus (33) and individual and multiple peripheral nerve branches (23 and 7, respectively). Twenty-five (38%) nerve injuries demonstrated spontaneous recovery. Thirty-five patients underwent surgical intervention, of which 27 were successful, 3 were partially successful, and 3 failed. Conclusions: This is the largest series of patients with iatrogenic nerve injury following shoulder surgeries to date. Our data demonstrate a lack of timely referral to nerve surgeons, especially after arthroscopy. There continues to be a variable injury pattern even among similar surgeries. Despite this, timely surgical intervention, when indicated, can lead to favorable outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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28. The Infected Tibial Nail

Author

Brady, Megan A., Cooper, Seth A., Patterson, Brendan M., Sethi, Manish K., editor, Obremskey, William T., editor, and Jahangir, A. Alex, editor

Published
2018
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36. Are Leaders Born to Lead, or Are They Made?

Author

Klifto, Christopher S., primary, Cheung, Emilie V., additional, Holcomb, Jason O., additional, Frankle, Mark A., additional, Duralde, Xavier A., additional, MacDonald, Peter B., additional, Ricchetti, Eric T., additional, Aibinder, William R., additional, Amini, Michael H., additional, Barnes, Leslie F., additional, Byram, Ian R., additional, Chalmers, Peter N., additional, Chuinard, Christopher R., additional, Friedman, Alan, additional, Gilotra, Mohit, additional, Gregory, James M., additional, Grogan, Brian F., additional, Horneff, John G., additional, Kassam, Hafiz, additional, Kazanjian, Jack E., additional, Kilcoyne, Kelly G., additional, Kowalsky, Marc S., additional, Li, Xinning, additional, Liu, Joseph N., additional, Muh, Stephanie J., additional, Munoz, Julianne, additional, Patterson, Brendan, additional, Phipatanakul, Wesley P., additional, Ward, Abner M., additional, Waterman, Brian R., additional, Woodmass, Jarret M., additional, and Wright, Melissa, additional

Published
2023
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46. Outcomes of geriatric periprosthetic distal femur fractures: comparison of fixation versus reconstruction

Author

Joseph, Noah M., primary, Zuke, William, additional, Sharpe, Megan, additional, Bacharach, Abigail, additional, Punjabi, Nihal, additional, Zhao, Chenya, additional, Sattar, Abdus, additional, Emara, Ahmed K., additional, Piuzzi, Nicolas S., additional, Ochenjele, George, additional, Patterson, Brendan M., additional, and Vallier, Heather A., additional

Published
2023
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