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1. The Italian experience on liver transplantation for unresectable peri-hilar cholangiocarcinoma: a national survey and future perspectives

Author

Gringeri, Enrico, Furlanetto, Alessandro, Billato, Ilaria, Cescon, Matteo, De Carlis, Luciano, Mazzaferro, Vincenzo, Romagnoli, Renato, De Simone, Paolo, Vivarelli, Marco, Di Benedetto, Fabrizio, Ravaioli, Matteo, Lauterio, Andrea, Sposito, Carlo, Patrono, Damiano, Ghinolfi, Davide, Moccheggiani, Federico, Di Sandro, Stefano, D’Amico, Francesco Enrico, Lanari, Jacopo, Gambato, Martina, Trapani, Silvia, Bergamo, Francesca, Cardillo, Massimo, Burra, Patrizia, and Cillo, Umberto

Published
2024
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2. Combined transarterial chemoembolization and thermal ablation in candidates to liver transplantation with hepatocellular carcinoma: pathological findings and post-transplant outcome

Author

Fronda, Marco, Susanna, Eleonora, Doriguzzi Breatta, Andrea, Gazzera, Carlo, Patrono, Damiano, Piccione, Federica, Bertero, Luca, Ciferri, Fernanda, Carucci, Patrizia, Gaia, Silvia, Rolle, Emanuela, Vocino Trucco, Giulia, Bergamasco, Laura, Tandoi, Francesco, Cassoni, Paola, Romagnoli, Renato, Fonio, Paolo, and Calandri, Marco

Published
2024
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6. Combined hepatocellular-cholangiocarcinoma compared to hepatocellular carcinoma and intrahepatic cholangiocarcinoma: Different survival, similar recurrence: Report of a large study on repurposed databases with propensity score matching

Author

Abba, Julio, Adam, René, Adham, Mustapha, Addeo, Pietro, Allard, Marc-Antoine, Amaddeo, Giuliana, Ayav, Ahmet, Azoulay, Daniel, Bachellier, Philippe, Balladur, Pierre, Barbieux, Julien, Boleslawski, Emmanuel, Boudjema, Karim, Bougard, M., Buc, Emmanuel, Bucur, Petru, Carmelo, Antoine, Cauchy, François, Chatelain, Denis, Chauvat, Jean, Cherkaoui, Zineb, Chirica, Mircea, Ciacio, Oriana, Codjia, Tatiana, Colli, Fabio, De Carlis, Luciano, Delpero, Jean-Robert, Demartines, Nicolas, Detry, Olivier, Sanches, Marcelo Dias, Diouf, Momar, Doussot, Alexandre, Ducerf, Christian, El Amrani, Mehdi, Ewald, Jacques, Fabre, Jean-Marc, Fagot, Hervé, Famularo, Simone, Ferre, Léo, Fleres, Francesco, Fonseca, Gilton Marques, Quintana, Álvaro Gancedo, Gayet, Brice, Giacomoni, Alessandro, Gigot, Jean-Francois, Golse, Nicolas, Gregoire, Emilie, Hardwigsen, Jean, Herman, Paulo, Hor, Thevi, Jehaes, François, Kianmanesh, Ali-Reza, Komatsu, Shohei, Laroche, Sophie, Laurent, Christophe, Le Treut, Yves-Patrice, Leourier, Philippe, Lermite, Emilie, Lesurtel, Mikael, Letoublon, Christian, Leyman, Paul, Lesurtel, Mickael, Lubrano, Jean, Mabrut, Jean-Yves, Mantion, Georges, Marchese, Ugo, Martín-Pérez, Elena, Menahem, Benjamin, Meunier, Maxime, Millet, Guillaume, Mohkam, Kayvan, Mulliri, André, Muscari, Fabrice, Navarro, Francis, Nolasco, Francisco, Nomi, Takeo, Nunoz, Jean, Nuzzo, Gennaro, Okumura, Shinya, Oudafal, Nassima, Pascal, Gerard, Passot, Guillaume, Patrono, Damiano, Paye, François, Perdigao, Fabiano, Petrucciani, Niccolo, Pittau, Gabriella, Pruvot, François-René, Raventos, Artigas, Regnault, Hélène, Rivoire, Michel, Romagnoli, Renato, Roulin, Didier, Sa-Cunha, Antonio, Scotte, Michel, Souche, François-Regis, Suc, Bertrand, Thobie, Alexandre, Trechot, Boris, Truant, Stéphanie, Turini, Olivier, Uemoto, Shinji, Unterteiner, Xavier, Vanbrugghe, Charles, Zemour, Jean, Amory, Boris, Goumard, Claire, Laurent, Alexis, Langella, Serena, Cherqui, Daniel, Salame, Ephrem, Barbier, Louise, Soubrane, Olivier, Farges, Olivier, Hobeika, Christian, Kawai, Takayuki, Regimbeau, Jean-Marc, Faitot, François, Pessaux, Patrick, Herrero, Astrid, Chiche, Laurence, Di Martino, Marcello, Rhaiem, Rami, Schwarz, Lilian, Resende, Vivian, Calderaro, Julien, Augustin, Jérémy, Caruso, Stefano, Sommacale, Daniele, Hofmeyr, Stefan, Ferrero, Alessandro, Fuks, David, Vibert, Eric, Torzilli, Guido, Scatton, Olivier, and Brustia, Raffaele

Published
2024
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7. Long-term outcomes after hypothermic oxygenated machine perfusion and transplantation of 1,202 donor livers in a real-world setting (HOPE-REAL study)

Author

Eden, Janina, Brüggenwirth, Isabel M.A., Berlakovich, Gabriela, Buchholz, Bettina M., Botea, Florin, Camagni, Stefania, Cescon, Matteo, Cillo, Umberto, Colli, Fabio, Compagnon, Philippe, De Carlis, Luciano G., De Carlis, Riccardo, Di Benedetto, Fabrizio, Dingfelder, Jule, Diogo, Dulce, Dondossola, Daniele, Drefs, Moritz, Fronek, Jiri, Germinario, Giuliana, Gringeri, Enrico, Györi, Georg, Kocik, Matej, Küçükerbil, Efrayim H., Koliogiannis, Dionysios, Lam, Hwai-Ding, Lurje, Georg, Magistri, Paolo, Monbaliu, Diethard, Moumni, Mostafa el, Patrono, Damiano, Polak, Wojciech G., Ravaioli, Matteo, Rayar, Michel, Romagnoli, Renato, Sörensen, Gustaf, Uluk, Deniz, Schlegel, Andrea, Porte, Robert J., Dutkowski, Philipp, and de Meijer, Vincent E.

Published
2024
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8. Improving outcomes of in situ split liver transplantation in Italy over the last 25 years

Author

Lauterio, Andrea, Cillo, Umberto, Spada, Marco, Trapani, Silvia, De Carlis, Riccardo, Bottino, Giuliano, Bernasconi, Davide, Scalamogna, Chiara, Pinelli, Domenico, Cintorino, Davide, D’Amico, Francesco Enrico, Spagnoletti, Gionata, Miggino, Marco, Romagnoli, Renato, Centonze, Leonardo, Caccamo, Lucio, Baccarani, Umberto, Carraro, Amedeo, Cescon, Matteo, Vivarelli, Marco, Mazaferro, Vincenzo, Ettorre, Giuseppe Maria, Rossi, Massimo, Vennarecci, Giovanni, De Simone, Paolo, Angelico, Roberta, Agnes, Salvatore, Di Benedetto, Fabrizio, Lupo, Luigi Giovanni, Zamboni, Fausto, Zefelippo, Arianna, Patrono, Damiano, Diviacco, Pietro, Laureiro, Zoe Larghi, Gringeri, Enrico, Di Francesco, Fabrizio, Lucianetti, Alessandro, Valsecchi, Maria Grazia, Gruttadauria, Salvatore, De Feo, Tullia, Cardillo, Massimo, De Carlis, Luciano, Colledan, Michele, and Andorno, Enzo

Published
2023
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9. Alternative forms of portal vein revascularization in liver transplant recipients with complex portal vein thrombosis

Author

Fundora, Yiliam, Hessheimer, Amelia J., Del Prete, Luca, Maroni, Lorenzo, Lanari, Jacopo, Barrios, Oriana, Clarysse, Mathias, Gastaca, Mikel, Barrera Gómez, Manuel, Bonadona, Agnès, Janek, Julius, Boscà, Andrea, Álamo Martínez, Jose María, Zozaya, Gabriel, López Garnica, Dolores, Magistri, Paolo, León, Francisco, Magini, Giulia, Patrono, Damiano, Ničovský, Jiří, Hakeem, Abdul Rahman, Nadalin, Silvio, McCormack, Lucas, Palacios, Pilar, Zieniewicz, Krzysztof, Blanco, Gerardo, Nuño, Javier, Pérez Saborido, Baltasar, Echeverri, Juan, Bynon, J. Steve, Martins, Paulo N., López López, Víctor, Dayangac, Murat, Lodge, J. Peter A., Romagnoli, Renato, Toso, Christian, Santoyo, Julio, Di Benedetto, Fabrizio, Gómez-Gavara, Concepción, Rotellar, Fernando, Gómez-Bravo, Miguel Ángel, López Andújar, Rafael, Girard, Edouard, Valdivieso, Andrés, Pirenne, Jacques, Lladó, Laura, Germani, Giacomo, Cescon, Matteo, Hashimoto, Koji, Quintini, Cristiano, Cillo, Umberto, Polak, Wojciech G., and Fondevila, Constantino

Published
2023
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11. Prolonged preservation by hypothermic machine perfusion facilitates logistics in liver transplantation: A European observational cohort study

Author

Brüggenwirth, Isabel M.A., Mueller, Matteo, Lantinga, Veerle A., Camagni, Stefania, De Carlis, Riccardo, De Carlis, Luciano, Colledan, Michele, Dondossola, Daniele, Drefs, Moritz, Eden, Janina, Ghinolfi, Davide, Koliogiannis, Dionysios, Lurje, Georg, Manzia, Tommaso M., Monbaliu, Diethard, Muiesan, Paolo, Patrono, Damiano, Pratschke, Johann, Romagnoli, Renato, Rayar, Michel, Roma, Federico, Schlegel, Andrea, Dutkowski, Philipp, Porte, Robert J., and de Meijer, Vincent E.

Published
2022
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12. Outcome of liver transplantation with grafts from brain-dead donors treated with dual hypothermic oxygenated machine perfusion, with particular reference to elderly donors

Author

Patrono, Damiano, Cussa, Davide, Sciannameo, Veronica, Montanari, Elena, Panconesi, Rebecca, Berchialla, Paola, Lepore, Mirella, Gambella, Alessandro, Rizza, Giorgia, Catalano, Giorgia, Mirabella, Stefano, Tandoi, Francesco, Lupo, Francesco, Balagna, Roberto, Salizzoni, Mauro, and Romagnoli, Renato

Published
2022
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13. Laparoscopic versus open liver resection for intrahepatic cholangiocarcinoma: Report of an international multicenter cohort study with propensity score matching

Author

Abba, Julio, Adam, René, Adham, Mustapha, Allard, Marc-Antoine, Ayav, Ahmet, Azoulay, Daniel, Bachellier, Philippe, Balladur, Pierre, Barbier, Louise, Barbieux, Julien, Boleslawski, Emmanuel, Boudjema, Karim, Bougard, M., Buc, Emmanuel, Bucur, Petru, Carmelo, Antoine, Chatelain, Denis, Chauvat, Jean, Cherkaoui, Zineb, Chiche, Laurence, Chirica, Mircea, Ciacio, Oriana, Codjia, Tatiana, Colli, Fabio, De Carlis, Luciano, Delpero, Jean-Robert, Demartines, Nicolas, Detry, Olivier, Sanches, Marcelo Dias, Diouf, Momar, Doussot, Alexandre, Ducerf, Christian, El Amrani, Mehdi, Ewald, Jacques, Fabre, Jean-Marc, Fagot, Hervé, Famularo, Simone, Ferre, Léo, Fleres, Francesco, Fonseca, Gilton Marques, Gayet, Brice, Giacomoni, Alessandro, Gigot, Jean-Francois, Girard, E., Golse, Nicolas, Gregoire, Emilie, Hardwigsen, Jean, Herman, Paulo, Hor, Thevi, Jehaes, François, Kianmanesh, Ali-Reza, Komatsu, Shohei, Laroche, Sophie, Laurent, Christophe, Le Treut, Yves-Patrice, Lecolle, K., Leourier, Philippe, Lermite, Emilie, Lesurtel, Mikael, Letoublon, Christian, Leyman, Paul, Lubrano, Jean, Mabrut, Jean-Yves, Mantion, Georges, Marchese, Ugo, Memeo, Riccardo, Millet, Guillaume, Mohkam, Kayvan, Mulliri, André, Muscari, Fabrice, Navarro, Francis, Nolasco, Francisco, Nomi, Takeo, Nunoz, Jean, Nuzzo, Gennaro, Oudafal, Nassima, Pascal, Gerard, Passot, Guillaume, Patrice, D., Patrono, Damiano, Paye, François, Perdigao, Fabiano, Pessaux, Patrick, Petrucciani, Niccolo, Pittau, Gabriella, Ratajczak, C., Raventos, Artigas, Rebibo, Lionel, Resende, Vivian, Rivoire, Michel, Romagnoli, Renato, Roulin, Didier, Sa-Cunha, Antonio, Salame, Ephrem, Schielke, Astrid, Schwarz, Lilian, Scotte, Michel, Souche, François-Regis, Suc, Bertrand, Tedeschi, Michele, Thobie, Alexandre, Trechot, Boris, Truant, Stéphanie, Turini, Olivier, Uemoto, Shinji, Unterteiner, Xavier, Vanbrugghe, Charles, Zemour, Jean, Brustia, Raffaele, Laurent, Alexis, Goumard, Claire, Langella, Serena, Cherqui, Daniel, Kawai, Takayuki, Soubrane, Olivier, Cauchy, Francois, Farges, Olivier, Menahem, Benjamin, Hobeika, Christian, Rhaiem, Rami, Sommacale, Daniele, Okumura, Shinya, Hofmeyr, Stefan, Ferrero, Alessandro, Pruvot, François-René, Regimbeau, Jean-Marc, Fuks, David, Vibert, Eric, and Scatton, Olivier

Published
2022
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14. Recipient hepatectomy technique may affect oncological outcomes of Liver Transplantation for hepatocellular carcinoma

Author

Pravisani, Riccardo, primary, De Martino, Maria, additional, Mocchegiani, Federico, additional, Melandro, Fabio, additional, Patrono, Damiano, additional, Lauterio, Andrea, additional, Di Francesco, Fabrizio, additional, Ravaioli, Matteo, additional, Zambelli, Marco Fabrizio, additional, Bosio, Claudio, additional, Dondossola, Daniele, additional, Lai, Quirino, additional, Zanchetta, Matteo, additional, Dingfelder, Jule, additional, Toti, Luca, additional, Iacomino, Alessandro, additional, Nicolae, Sermed, additional, Ghinolfi, Davide, additional, Romagnoli, Renato, additional, De Carlis, Luciano, additional, Gruttadauria, Salvatore, additional, Cescon, Matteo, additional, Colledan, Michele, additional, Carraro, Amedeo, additional, Caccamo, Lucio, additional, Vivarelli, Marco, additional, Rossi, Massimo, additional, Nadalin, Silvio, additional, Gyori, Georg, additional, Tisone, Giuseppe, additional, Vennarecci, Giovanni, additional, Rostved, Andreas, additional, De Simone, Paolo, additional, Isola, Miriam, additional, and Baccarani, Umberto, additional

Published
2024
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16. An Italian survey on the use of T-tube in liver transplantation: old habits die hard!

Author

Pravisani, Riccardo, De Simone, Paolo, Patrono, Damiano, Lauterio, Andrea, Cescon, Matteo, Gringeri, Enrico, Colledan, Michele, Di Benedetto, Fabrizio, di Francesco, Fabrizio, Antonelli, Barbara, Manzia, Tommaso Maria, Carraro, Amedeo, Vivarelli, Marco, Regalia, Enrico, Vennarecci, Giovanni, Guglielmo, Nicola, Cesaretti, Manuela, Avolio, Alfonso Wolfango, Valentini, Maria Filippa, Lai, Quirino, and Baccarani, Umberto

Published
2021
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17. Protective Role of Tacrolimus, Deleterious Role of Age and Comorbidities in Liver Transplant Recipients With Covid-19: Results From the ELITA/ELTR Multi-center European Study

Author

Belli, Luca S., Fondevila, Constantino, Cortesi, Paolo A., Conti, Sara, Karam, Vincent, Adam, Rene, Coilly, Audrey, Ericzon, Bo Goran, Loinaz, Carmelo, Cuervas-Mons, Valentin, Zambelli, Marco, Llado, Laura, Diaz-Fontenla, Fernando, Invernizzi, Federica, Patrono, Damiano, Faitot, Francois, Bhooori, Sherrie, Pirenne, Jacques, Perricone, Giovanni, Magini, Giulia, Castells, Lluis, Detry, Oliver, Cruchaga, Pablo Mart, Colmenero, Jordi, Berrevoet, Frederick, Rodriguez, Gonzalo, Ysebaert, Dirk, Radenne, Sylvie, Metselaar, Herold, Morelli, Cristina, De Carlis, Luciano G., Polak, Wojciech G., and Duvoux, Christophe

Published
2021
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18. Liver Transplantation for Hepatocellular Carcinoma in the Era of Immune Checkpoint Inhibitors.

Author

De Stefano, Nicola, Patrono, Damiano, Colli, Fabio, Rizza, Giorgia, Paraluppi, Gianluca, and Romagnoli, Renato

Subjects
*LEGAL evidence, *RISK assessment, *CANCER relapse, *IMMUNOTHERAPY, *CELLULAR signal transduction, *IMMUNE checkpoint inhibitors, *GRAFT rejection, *LIVER transplantation, *HEPATOCELLULAR carcinoma, *PHARMACODYNAMICS
Abstract

Simple Summary: Immune checkpoint inhibitors (ICIs) have witnessed significant success in systemic therapy of hepatocellular carcinoma, stimulating the transplant community to consider their use in the liver transplantation (LT) setting. This review provides an updated overview of the current evidence on ICI therapy before and after LT, discussing the associated pitfalls and remaining challenges. A particular focus is placed on the interactions between ICIs and immunosuppressive drugs, in order to identify predictive factors of good response, as well as critical aspects that should guide future research on the topic. Hepatocellular carcinoma (HCC) remains the leading oncological indication for liver transplantation (LT), with evolving and broadened inclusion criteria. Immune checkpoint inhibitors (ICIs) gained a central role in systemic HCC treatment and showed potential in the peri-transplant setting as downstaging/bridging therapy before LT or as a treatment for HCC recurrence following LT. However, the antagonistic mechanisms of action between ICIs and immunosuppressive drugs pose significant challenges, particularly regarding the risk of acute rejection (AR). This review analyzes the main signaling pathways targeted by ICI therapies and summarizes current studies on ICI therapy before and after LT. The literature on this topic is limited and highly heterogeneous, precluding definitive evidence-based conclusions. The use of ICIs before LT appears promising, provided that a sufficient wash-out period is implemented. In contrast, the results of post-LT ICI therapy do not support its wide clinical application due to high AR rates and overall poor response to treatment. In the future, modern graft preservation techniques might support the selection of good ICI responders, but data from high-level studies are urgently needed. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Global management of a common, underrated surgical task during the COVID-19 pandemic: Gallstone disease - An international survery

Author

Al Alawy, Yousef, Arif, Abdul Jabba, Attia, Magdy, Bhati, Chandra, Battula R, Narendra, Bonney, Glenn Kunnath, Brooke-Smith, Mark, Derosas, Carlos, De Liguori Carino, Nicola, Ferretti, Stefano, Fiorani, Cristina, Gherardi, Dario, Hegab, Bassem, Hussain, Zaki, Ielpo, Benedetto, Iesari, Samuele, Lai, Quirino, Lainas, Panagiotis, Lauterio, Andrea, Lazzaro, Alessandra, Marudanayagam, Ravi, Nasralla, David, Nicolini, Daniele, Orlando, Giuseppe, Patrono, Damiano, Pitchaimuthu, Maheswaran, Polak, Wojciech, Quinto, Alberto Marcacuzco, Rai, Rakesh, Scalera, Irene, Schlegel, Andrea, Shanmugam, Vivek, Vitale, Alessandro, Widmer, Jeannette, Yannick, Deswysen, Manzia, Tommaso Maria, Angelico, Roberta, Parente, Alessandro, Muiesan, Paolo, and Tisone, Giuseppe

Published
2020
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21. Preoperative risk score for prediction of long-term outcomes after hepatectomy for intrahepatic cholangiocarcinoma: Report of a collaborative, international-based, external validation study

Author

Uemoto, Shinji, Perdigao, Fabiano, Nolasco, Francisco, Laroche, Sophie, Romagnoli, Renato, Famularo, Simone, Brustia, Raffaele, Langella, Serena, Kawai, Takayuki, Fonseca, Gilton Marques, Schielke, Astrid, Colli, Fabio, Resende, Vivian, Fleres, Francesco, Roulin, Didier, Leyman, Paul, Giacomoni, Alessandro, Granger, Benjamin, Fartoux, Laetitia, De Carlis, Luciano, Demartines, Nicolas, Sommacale, Daniele, Sanches, Marcelo Dias, Patrono, Damiano, Detry, Olivier, Herman, Paulo, Okumura, Shinya, Ferrero, Alessandro, and Scatton, Olivier

Published
2020
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23. Guidelines for Perioperative Care for Liver Transplantation: Enhanced Recovery After Surgery (ERAS) Recommendations

Author

Brustia, Raffaele, Monsel, Antoine, Skurzak, Stefano, Schiffer, Eduardo, Carrier, François Martin, Patrono, Damiano, Kaba, Abdourahamane, Detry, Olivier, Malbouisson, Luiz, Andraus, Wellington, Vandenbroucke-Menu, Franck, Biancofiore, Gianni, Kaido, Toshimi, Compagnon, Philippe, Uemoto, Shinji, Rodriguez Laiz, Gonzalo, De Boer, Marieke, Orloff, Susan, Melgar, Paola, Buis, Carlijn, Zeillemaker-Hoekstra, Miriam, Usher, Helen, Reyntjens, Koen, Baird, Emily, Demartines, Nicolas, Wigmore, Stephen, and Scatton, Olivier

Published
2022
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27. Viability assessment of livers donated after circulatory determination of death during normothermic regional perfusion

Author

Steinberg, Irene, primary, Patrono, Damiano, additional, De Cesaris, Enrico, additional, Lucà, Michele, additional, Catalano, Giorgia, additional, Marro, Matteo, additional, Rizza, Giorgia, additional, Simonato, Erika, additional, Brazzi, Luca, additional, Romagnoli, Renato, additional, and Zanierato, Marinella, additional

Published
2023
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28. How to Preserve Liver Grafts From Circulatory Death With Long Warm Ischemia? A Retrospective Italian Cohort Study With Normothermic Regional Perfusion and Hypothermic Oxygenated Perfusion

Author

De Carlis, Riccardo, Schlegel, Andrea, Frassoni, Samuele, Olivieri, Tiziana, Ravaioli, Matteo, Camagni, Stefania, Patrono, Damiano, Bassi, Domenico, Pagano, Duilio, Di Sandro, Stefano, Lauterio, Andrea, Bagnardi, Vincenzo, Gruttadauria, Salvatore, Cillo, Umberto, Romagnoli, Renato, Colledan, Michele, Cescon, Matteo, Di Benedetto, Fabrizio, Muiesan, Paolo, and De Carlis, Luciano

Published
2021
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31. Location and allocation

Author

Artzner, Thierry, Bernal, William, Belli, Luca S, Conti, Sara, Cortesi, Paolo A, Sacleux, Sophie‐Caroline, Pageaux, George‐Philippe, Radenne, Sylvie, Trebicka, Jonel, Fernandez, Javier, Perricone, Giovanni, Piano, Salvatore, Nadalin, Silvio, Morelli, Maria C, Martini, Silvia, Polak, Wojciech G, Zieniewicz, Krzysztof, Toso, Christian, Berenguer, Marina, Iegri, Claudia, Invernizzi, Federica, Volpes, Riccardo, Karam, Vincent, Adam, René, Faitot, François, Rabinowich, Liane, Saliba, Faouzi, Meunier, Lucy, Lesurtel, Mickael, Uschner, Frank E, Michard, Baptiste, Coilly, Audrey, Meszaros, Magdalena, Poinsot, Domitille, Besch, Camille, Schnitzbauer, Andreas, De Carlis, Luciano G, Fumagalli, Roberto, Angeli, Paolo, Arroyo, Vincente, Fondevila, Constantino, Duvoux, Christophe, Jalan, Rajiv, Viganò, Raffaella, Mazzarelli, Chiara, Lauterio, Andrea, Giacomoni, Alessandro, Donato, Francesca, Lampertico, Pietro, Pasulo, Luisa, Fagiuoli, Stefano, Colledan, Michele, Cristina Morelli, Maria, Vitale, Giovanni, Ottobrelli, Antonio, Patrono, Damiano, Romagnoli, Renato, Petridis, Ioannis, Cillo, Umberto, Germani, Giacomo, Burra, Patrizia, Bachellier, Philippe, Schneider, Francis, Castelain, Vincent, Addeo, Pietro, Deridder, Mathilde, Caroline Sacleux Audrey Coilly, Sophie, Faouzi, Saliba, Adam, Rene, Samuel, Didier, Guichon, Celine, Faure, Stéfanie, Ursic‐Bedoya, Josè, Fondevila, Costantino, Colmenero, Jorde, Toapanta, David, Hernández‐Tejero, María, Vinaixa, Carmen, Polak, Wojciech G., den Hoed, Caroline, Haan, Jubi E., Della Penna, Andrea, Erhard Uschner, Frank, Welker, Martin, Zeuzem, Stefan, Bechstein, Wolf, Goossens, Nicolas, Raszeja‐Wyszomirska, Joanna, Rabinovich, Liane, Katarey, Dev, Agarwal, Banwari, Surgery, Gastroenterology & Hepatology, Intensive Care, Biomatériaux et Bioingénierie (BB), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie (ICube), École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Université de Strasbourg (UNISTRA)-Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Les Hôpitaux Universitaires de Strasbourg (HUS)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Interface de Recherche Fondamentale et Appliquée en Cancérologie (IRFAC - Inserm U1113), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Paul Strauss : Centre Régional de Lutte contre le Cancer (CRLCC)-Fédération de Médecine Translationelle de Strasbourg (FMTS), Mitochondrie, stress oxydant et protection musculaire (MSP), Université de Strasbourg (UNISTRA), the ELITA/EF-CLIF Working Group, Artzner, T, Bernal, W, Belli, L, Conti, S, Cortesi, P, Sacleux, S, Pageaux, G, Radenne, S, Trebicka, J, Fernandez, J, Perricone, G, Piano, S, Nadalin, S, Morelli, M, Martini, S, Polak, W, Zieniewicz, K, Toso, C, Berenguer, M, Iegri, C, Invernizzi, F, Volpes, R, Karam, V, Adam, R, Faitot, F, Rabinowich, L, Saliba, F, Meunier, L, Lesurtel, M, Uschner, F, Michard, B, Coilly, A, Meszaros, M, Poinsot, D, Besch, C, Schnitzbauer, A, De Carlis, L, Fumagalli, R, Angeli, P, Arroyo, V, Fondevila, C, Duvoux, C, Jalan, R, Viganò, R, Mazzarelli, C, Lauterio, A, Giacomoni, A, Donato, F, Lampertico, P, Pasulo, L, Fagiuoli, S, Colledan, M, Cristina Morelli, M, Vitale, G, Ottobrelli, A, Patrono, D, Romagnoli, R, Petridis, I, Cillo, U, Germani, G, Burra, P, Bachellier, P, Schneider, F, Castelain, V, Addeo, P, Deridder, M, Caroline Sacleux Audrey Coilly, S, Faouzi, S, Samuel, D, Guichon, C, Faure, S, Ursic‐bedoya, J, Colmenero, J, Toapanta, D, Hernández‐tejero, M, Vinaixa, C, den Hoed, C, Haan, J, Della Penna, A, Erhard Uschner, F, Welker, M, Zeuzem, S, Bechstein, W, Goossens, N, Raszeja‐wyszomirska, J, Rabinovich, L, Katarey, D, and Agarwal, B

Subjects
Transplantation, ILL CIRRHOTIC-PATIENTS, Liver transplantation, Hepatology, Intensive care, Waiting list, Surgery, Acute-on-Chronic Liver Failure, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

There is growing evidence that liver transplantation (LT) is the most effective treatment for acute-on-chronic liver failure grade-3 (ACLF-3). This study examines whether and how this evidence translates into practice by analyzing the variability in intensive care unit (ICU) admissions, listing strategies, and LT activity for patients with ACLF-3 across transplantation centers in Europe. Consecutive patients who were admitted to the ICU with ACLF-3, whether or not they were listed and/or transplanted with ACLF-3, between 2018 and 2019 were included across 20 transplantation centers. A total of 351 patients with ACLF-3 were included: 33 had been listed prior to developing ACLF-3 and 318 had not been listed at the time of admission to the ICU. There was no correlation between the number of unlisted patients with ACLF-3 admitted to the ICU and the number listed or transplanted while in ACLF-3 across centers. By contrast, there was a correlation between the number of patients listed and the number transplanted while in ACLF-3. About 21% of patients who were listed while in ACLF-3 died on the waiting list or were delisted. The percentage of LT for patients with ACLF-3 varied from 0% to 29% for those transplanted with decompensated cirrhosis across centers (average = 8%), with an I(2) index of 68% (95% confidence interval, 49%-80%), showing substantial heterogeneity among centers. The 1-year survival for all patients with ACLF-3 was significantly higher in centers that listed and transplanted more patients with ACLF-3 (>10 patients) than in centers that listed and transplanted fewer: 36% versus 20%, respectively (p = 0.012). Patients with ACLF-3 face inequity of access to LT across Europe. Waitlisting strategies for patients with ACLF-3 influence their access to LT and, ultimately, their survival.

Published
2022

37. Impact of Hypothermic Oxygenated Machine Perfusion on Hepatocellular Carcinoma Recurrence after Liver Transplantation

Author

Rigo, Federica, primary, De Stefano, Nicola, additional, Patrono, Damiano, additional, De Donato, Victor, additional, Campi, Ludovico, additional, Turturica, Diana, additional, Doria, Teresa, additional, Sciannameo, Veronica, additional, Berchialla, Paola, additional, Tandoi, Francesco, additional, and Romagnoli, Renato, additional

Published
2023
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41. Organ reconditioning and machine perfusion in transplantation

Author

UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, UCL - (SLuc) Service de chirurgie et transplantation abdominale, Bellini, Maria Irene, Bonaccorsi Riani, Eliano, Giorgakis, Emmanouil, Kaisar, Maria E., Patrono, Damiano, Weissenbacher, Annemarie, UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, UCL - (SLuc) Service de chirurgie et transplantation abdominale, Bellini, Maria Irene, Bonaccorsi Riani, Eliano, Giorgakis, Emmanouil, Kaisar, Maria E., Patrono, Damiano, and Weissenbacher, Annemarie

Abstract

Society’s self-sufficiency in terms of organ replacement is still far away from being achieved, given the large disparity between transplant demand and donor organ availability. In the attempt to reduce this discrepancy and expand the donor pool, the transplant community has progressively increased the utilisation of extended-criteria donors (ECD) such as older donors, donors with comorbidities and donation after circulatory death (DCD). The main challenge preventing a wider utilisation of ECD and DCD allografts is the higher susceptibility to the ischemia-reperfusion injury (IRI) (1), an unavoidable part of the transplantation process. For this reason, in the last decades, there has been an exponential development on organ reconditioning strategies, in order to enable graft resuscitation and viability assessment prior to implantation (2).

Published
2023

47. Splenic Vessels as a Rescue for Pediatric Kidney Retransplantation in Children With Iliac-caval Agenesis or Thrombosis

Author

Tandoi, Francesco, primary, Peruzzi, Licia, additional, Lonardi, Pietro, additional, Cussa, Davide, additional, Catalano, Silvia, additional, Verri, Aldo, additional, Merlo, Maurizio, additional, Sedigh, Omidreza, additional, Gerocarni Nappo, Simona, additional, Melloni, Claudia, additional, Patrono, Damiano, additional, Gianoglio, Bruno, additional, and Romagnoli, Renato, additional

Published
2022
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48. COVID-19 in liver transplant candidates

Author

Belli, Luca Saverio, Duvoux, Christophe, Cortesi, Paolo Angelo, Facchetti, Rita, Iacob, Speranta, Perricone, Giovanni, Radenne, Sylvie, Conti, Sara, Patrono, Damiano, Berlakovich, Gabriela, Hann, Angus, Pasulo, Luisa, Castells, Lluis, Faitot, Francois, Detry, Olivier, Invernizzi, Federica, Magini, Giulia, De Simone, Paolo, Kounis, Ilias, Morelli, Maria Cristina, Díaz Fontenla, Fernando, Ericzon, Bo-Göran, Loinaz, Carmelo, Johnston, Chris, Gheorghe, Liliana, Lesurtel, Mickael, Romagnoli, Renato, Kollmann, Dagmar, Perera, M Thamara Pr, Fagiuoli, Stefano, Mirza, Darius, Coilly, Audrey, Toso, Christian, Zieniewicz, Krzysztof, Elkrief, Laure, Karam, Vincent, Adam, Rene, den Hoed, Caroline, Merli, Marco, Puoti, Massimo, De Carlis, Luciano, Oniscu, Gabriel C, Piano, Salvatore, Angeli, Paolo, Fondevila, Constantino, Polak, Wojciech G, ELITA-ELTR COVID-19 Registry, Gastroenterology & Hepatology, Surgery, Belli, L, Duvoux, C, Cortesi, P, Facchetti, R, Iacob, S, Perricone, G, Radenne, S, Conti, S, Patrono, D, Berlakovich, G, Hann, A, Pasulo, L, Castells, L, Faitot, F, Detry, O, Invernizzi, F, Magini, G, De Simone, P, Kounis, I, Morelli, M, Diaz Fontenla, F, Ericzon, B, Loinaz, C, Johnston, C, Gheorghe, L, Lesurtel, M, Romagnoli, R, Kollmann, D, Perera, M, Fagiuoli, S, Mirza, D, Coilly, A, Toso, C, Zieniewicz, K, Elkrief, L, Karam, V, Adam, R, Den Hoed, C, Merli, M, Puoti, M, De Carlis, L, Oniscu, G, Piano, S, Angeli, P, Fondevila, C, and Polak, W

Subjects
0301 basic medicine, Male, medicine.medical_specialty, Waiting Lists, medicine.medical_treatment, liver cirrhosis, Pneumonia, Viral, Population, Liver transplantation, 03 medical and health sciences, Liver disease, 0302 clinical medicine, SDG 3 - Good Health and Well-being, Risk Factors, Internal medicine, Cause of Death, Medicine, Humans, Viral, Registries, education, Cause of death, education.field_of_study, ddc:617, liver transplantation, liver cirrhosi, Proportional hazards model, business.industry, SARS-CoV-2, Gastroenterology, COVID-19, Pneumonia, Middle Aged, medicine.disease, Transplant Recipients, Transplantation, Europe, 030104 developmental biology, Respiratory failure, Liver cirrhosis, 030211 gastroenterology & hepatology, Female, Liver Transplantation, business, Cohort study
Abstract

ObjectiveExplore the impact of COVID-19 on patients on the waiting list for liver transplantation (LT) and on their post-LT course.DesignData from consecutive adult LT candidates with COVID-19 were collected across Europe in a dedicated registry and were analysed.ResultsFrom 21 February to 20 November 2020, 136 adult cases with laboratory-confirmed SARS-CoV-2 infection from 33 centres in 11 European countries were collected, with 113 having COVID-19. Thirty-seven (37/113, 32.7%) patients died after a median of 18 (10–30) days, with respiratory failure being the major cause (33/37, 89.2%). The 60-day mortality risk did not significantly change between first (35.3%, 95% CI 23.9% to 50.0%) and second (26.0%, 95% CI 16.2% to 40.2%) waves. Multivariable Cox regression analysis showed Laboratory Model for End-stage Liver Disease (Lab-MELD) score of ≥15 (Model for End-stage Liver Disease (MELD) score 15–19, HR 5.46, 95% CI 1.81 to 16.50; MELD score≥20, HR 5.24, 95% CI 1.77 to 15.55) and dyspnoea on presentation (HR 3.89, 95% CI 2.02 to 7.51) being the two negative independent factors for mortality. Twenty-six patients underwent an LT after a median time of 78.5 (IQR 44–102) days, and 25 (96%) were alive after a median follow-up of 118 days (IQR 31–170).ConclusionsIncreased mortality in LT candidates with COVID-19 (32.7%), reaching 45% in those with decompensated cirrhosis (DC) and Lab-MELD score of ≥15, was observed, with no significant difference between first and second waves of the pandemic. Respiratory failure was the major cause of death. The dismal prognosis of patients with DC supports the adoption of strict preventative measures and the urgent testing of vaccination efficacy in this population. Prior SARS-CoV-2 symptomatic infection did not affect early post-transplant survival (96%).

Published
2021

50. How to Preserve Steatotic Liver Grafts for Transplantation.

Author

Patrono, Damiano, De Stefano, Nicola, Vissio, Elena, Apostu, Ana Lavinia, Petronio, Nicoletta, Vitelli, Giovanni, Catalano, Giorgia, Rizza, Giorgia, Catalano, Silvia, Colli, Fabio, Chiusa, Luigi, and Romagnoli, Renato

Subjects
*LIVER transplantation, *FATTY liver, *PREOPERATIVE risk factors, *LIVER histology, *REPERFUSION injury, *HOMOGRAFTS, *GRAFT survival, *FATTY degeneration
Abstract

Liver allograft steatosis is a significant risk factor for postoperative graft dysfunction and has been associated with inferior patient and graft survival, particularly in the case of moderate or severe macrovesicular steatosis. In recent years, the increasing incidence of obesity and fatty liver disease in the population has led to a higher proportion of steatotic liver grafts being used for transplantation, making the optimization of their preservation an urgent necessity. This review discusses the mechanisms behind the increased susceptibility of fatty livers to ischemia-reperfusion injury and provides an overview of the available strategies to improve their utilization for transplantation, with a focus on preclinical and clinical evidence supporting donor interventions, novel preservation solutions, and machine perfusion techniques. [ABSTRACT FROM AUTHOR]

Published
2023
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