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5. A prospective observational study on the efficacy of procalcitonin as a diagnostic test to exclude lower urinary tract infection and to minimize antibiotic overuse.

Author

Acharya, Swastik, Mishra, Sanjukta, Ghosh, Arpan, and Patro, Shubhransu

Subjects
MEDICAL sciences, BLOOD cell count, ANTIBIOTIC overuse, DRUG resistance in bacteria, RESPIRATORY infections, URINARY tract infections
Abstract

Background: Urinary tract infection (UTI) stands out as the third-most common infection following gastrointestinal and respiratory tract infections. Over the past decade, the biomarker procalcitonin (PCT) has gained prominence to facilitate the detection of bacterial infections and reduce excessive antibiotic exposure. Objective: The objective of this study was to mitigate the overuse of antibiotics, by promoting the noninitiation or early discontinuation of empirical antibiotics, which would significantly help minimize the proliferation of multidrug-resistant bacteria. Methodology: A prospective observational study was carried out at the tertiary care center in the Department of General Medicine of Kalinga Institute of Medical Sciences, Bhubaneswar, involving 200 patients with symptoms of lower UTI such as increased frequency, urgency, burning micturition, retention, and suprapubic tenderness with or without positive urinalysis. Detailed demographic profiles along with symptoms at the time of admission were recorded in a pretested structured format. To determine a positive diagnosis of UTI, signs and symptoms of UTI with or without urinary cultures were tested. The PCT level was estimated using enhanced chemiluminescence technique. Other routine tests such as complete blood count, renal function test, liver function test, urine routine microscopy, culture, chest X-ray, and ultrasonography abdomen pelvis were done and recorded. All patients, who had an initial serum PCT level of < 0.5 ng/mL, were kept under observation with only conservative and symptomatic treatments. Patients were further reviewed for improvement in symptoms and repeat urine microscopy. All patients, who had an initial serum PCT level of > 0.5 ng/mL, were initiated with antibiotics as per the culture and sensitivity reports. Patients were followed up for improvement in symptoms with reports of repeated urinalysis. Results: Our study reported the fact that 9.5% of the patients with initial serum PCT = 0.5 ng/mL showed no improvement in symptoms despite starting antibiotics while significantly higher number of symptomatic patients (60%) with initial serum PCT < 0.5 ng/ml showed improvement in symptoms with conservative treatment without antibiotics. Conclusion: A lower PCT level rules out bacterial invasion and thus can be used as a novel marker in antibiotic stewardship. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Redefining Lobe-Wise Ground-Glass Opacity in COVID-19 Through Deep Learning and its Correlation With Biochemical Parameters

Author

Baral, Budhadev, primary, Muduli, Kartik, additional, Jakhmola, Shweta, additional, Indari, Omkar, additional, Jangir, Jatin, additional, Rashid, Ashraf Haroon, additional, Jain, Suchita, additional, Mohapatra, Amrut Kumar, additional, Patro, Shubhransu, additional, Parida, Preetinanda, additional, Misra, Namrata, additional, Mohanty, Ambika Prasad, additional, Sahu, Bikash R, additional, Jain, Ajay Kumar, additional, Elangovan, Selvakumar, additional, Parmar, Hamendra Singh, additional, Tanveer, M., additional, Mohakud, Nirmal Kumar, additional, and Jha, Hem Chandra, additional

Published
2023
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18. Additional file 5 of Designing a novel multi-epitope vaccine to evoke a robust immune response against pathogenic multidrug-resistant Enterococcus faecium bacterium

Author

Dey, Jyotirmayee, Mahapatra, Soumya Ranjan, Raj, T. Kiran, Kaur, Taranjeet, Jain, Parul, Tiwari, Arushi, Patro, Shubhransu, Misra, Namrata, and Suar, Mrutyunjay

Abstract

Additional file 5: Table S5. Physicochemical properties, secondary structure, and solubility analysis of final vaccine construct as predicted by ProtParam tool, PSIPRED, and SOLpro server.

Published
2022
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20. Comparative Evaluation of Cartridge-Based Abbott ID NOW Test With Probe-Based Real-Time Reverse Transcription Polymerase Chain Reaction Assay for Detection of SARS-CoV-2

Author

Pattnaik, Dipti, primary, Poddar, Nirmala, additional, Pathi, Basanti K, additional, Panigrahi, Kumudini, additional, Sabat, Smaranita, additional, Roy, Ankita, additional, Patro, A. Raj K, additional, Mohapatra, Amrut, additional, Patro, Shubhransu, additional, and Praharaj, Ashok K, additional

Published
2022
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25. Supervised hospital based pulmonary rehabilitation outcome in long COVID–experience from a tertiary care hospital.

Author

Rao, C, Behera, Debasis, Mohapatra, Amrut, Mohapatra, Sangram, Jagaty, Suman, Banu, Princia, Pattanaik, Ashwini, Mohapatra, Ipsa, and Patro, Shubhransu

Subjects
COUGH, POST-acute COVID-19 syndrome, COVID-19 pandemic, TERTIARY care, ELECTRONIC health records, REHABILITATION
Abstract

Introduction: Some patients suffer from various multisystem symptoms even after active process of COVID-19 illness has settled lasting more than four weeks called as long COVID. Pulmonary rehabilitation therapy is the proposed option in those patients. This study aims to study the impact of pulmonary rehabilitation on outcome of long COVID patients through improvement in mMRC dyspnea scale, oxygen saturation, cough score, six-minute walk distance and biomarkers of inflammation Materials and Methods: A retrospective observational study was carried out from the data of electronic medical records among 71 Long COVID patients. Parameters like Spo2, MMRC scale, cough score, six-minute walking distance along with blood levels of D-dimer, C-reactive protein (CRP), leucocyte count at the time of admission and after three weeks of pulmonary rehabilitation were collected. The outcome among the patients was divided into full recovery and partial recovery group. Statistical analysis was done using SPSS software version 19.0. Result: Among 71 cases in our study 60 (84.50%) where male with mean age was 52.7 ± 13.23 years. Biomarkers like CRP and d-Dimer were elevated in 68 (95.7%) and 48 (67.6%) patients, respectively, at the time of admission. After 3 weeks of pulmonary rehabilitation mean SPO2, cough score, 6MWD showed significant improvement and normalization of biomarkers in recovered group of 61 out of 71 which was statistically significant. Conclusion: Significant improvement of oxygen saturation, mMRC grade, cough score, six-minute walk distance and normalization of biomarkers were marked following pulmonary rehabilitation. Thus, pulmonary rehabilitation therapy should be offered to all long COVID cases. [ABSTRACT FROM AUTHOR]

Published
2022
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26. A single-centre experience of scrub typhus in a tertiary care centre - a re-emerging infection

Author

Sahoo, Debananda, Maikap, Debasish, Mohanty, Lalatendu, Patro, Shubhransu, Panda, Sudhansu, Mohanty, Ambika, Sahoo, Debananda, Maikap, Debasish, Mohanty, Lalatendu, Patro, Shubhransu, Panda, Sudhansu, and Mohanty, Ambika

Abstract

Background: Scrub typhus is a documented disease in Himachal Pradesh, but there have been few clinico-epidemiological studies in this area. The present study is done with IgM ELISA as a diagnostic test which has higher sensitivity and specificity as most of the previous studies had used Weil Felix test as a diagnostic test. Methodology: This was a prospective observational study. All the patients more than 18 years of age with positive IgM ELISA for scrub typhus with/without eschar were included. The clinical profile was observed. IgM scrub typhus was done by ELISA. Results: Total of 39 patients were observed between July 2016 to Dec 2016. Maximum patients were observed in August, September, and October. Fever with Headache was the most common presenting complaint. Eschar was present in 10 % patients. Complications were seen in 76.92 %. The mortality rate was 0 %. Conclusion: The varied presentations and high rate of complications require a high index of suspicion for Scrub Typhus. The general physicians should be sensitized for the early diagnosis and treatment to reduce morbidity and mortality.

Published
2020

47. Roseomonas Gilardii, A Pink Non-Fermenter Associated with Bacteremia: A Rare Case.

Author

Patro, Shubhransu, Mishra, Surya Narayan, and Deo, Dandi Suryanarayana

Subjects
BACTEREMIA, ACUTE diseases, PINK, AMIKACIN
Abstract

R. gilardii is a pink gram-negative coccobacillus belonging to the genus Roseomonas. Here we are going to discuss about a case which is presented as acute febrile illness. Roseomonas gilardii has been isolated from the blood specimen of the patient. She has been treated with Amikacin referring to previous literature¹. The patient started recovering and was discharged in a recovery phase. [ABSTRACT FROM AUTHOR]

Published
2020

48. Burkholderia cepaciainfection associated with sickle cell disease: An uncommon entity

Author

Singh, Pratima, Patro, Shubhransu, Deep, Akash, and Mohapatra, Sangram Keshari

Abstract

Burkholderia, a multidrug-resistant Gram-negative bacteria, is an uncommon cause of infection mostly in immunocompromised patients with a clinical profile very similar to tuberculosis. The most common conditions associated with this organism are cystic fibrosis and chronic granulomatous diseases. Bacteremia with it occurs in patients who are chronically ill and associated with significant morbidity and mortality. We are reporting here a case of perisplenic intra-abdominal abscess caused by Burkholderia cepaciain a patient with sickle cell disease (SCD).

Published
2023
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