1. Comparison of different methods for the extraction of cannabinoids from cannabis
- Author
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Roberto Di Santo, Antonella Messore, Daniela De Vita, Valentina Noemi Madia, Alfonso Botto, Valeria Tudino, Alessandro De Leo, Ivano Pindinello, Roberta Costi, Gianluigi Santilli, Francesco Saccoliti, Luigi Scipione, and Patrizia Roscilli
- Subjects
Cannabis extraction ,industrial hemp ,medicinal cannabis ,microwave-assisted extraction ,ultrasound-assisted extraction ,Human immunodeficiency virus (HIV) ,Polysorbates ,Plant Science ,Chemical Fractionation ,medicine.disease_cause ,01 natural sciences ,Biochemistry ,Analytical Chemistry ,Surface-Active Agents ,medicine ,Medicinal Cannabis ,Ultrasonics ,Microwaves ,Cannabis ,Alternative methods ,Traditional medicine ,biology ,Molecular Structure ,010405 organic chemistry ,business.industry ,Cannabinoids ,Plant Extracts ,Organic Chemistry ,Extraction (chemistry) ,biology.organism_classification ,0104 chemical sciences ,010404 medicinal & biomolecular chemistry ,business - Abstract
Cannabis oils, namely concentrated cannabis extracts, are getting plenty of attention because of their therapeutic potential for treatment of patients with cancer, HIV, multiple sclerosis and several other pathologies. Here we propose the use of ultrasound-assisted extraction (UAE) and microwave-assisted extraction (MAE) as alternative methods to the current protocols followed by pharmacists, the only authorized to manipulate standardized Cannabis. A third method, consisting of the use of Tween 20 as surfactant, was considered. Our best extraction methodology for commercial hemp extraction was applied to medicinal cannabis. Here we report the results obtained for ‘Eletta campana’, ‘Carmagnola selezionata’, Bediol®, FM2® and Bedrocan®.
- Published
- 2020
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